Ocular insert apparatus and methods

A technology for inserts and eyes, which is applied in ophthalmic treatment, pharmaceutical formulations, prostheses, etc., and can solve the problems of inserts touching the cornea, low release rate curve, and not being comfortable

Inactive Publication Date: 2014-07-09
弗赛特影像5股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Existing insert devices can be less than ideal, and blinking in at least some cases can cause the insert to contact the cornea, or rub the eyelid or conjunctiva, causing patient discomfort in at least some cases
Furthermore, given that existing insert structures can remain in the eye for extended periods of time, the release rate profile for the amount of drug released and the amount released for extended periods of time may be low in at least some instances for at least some of the existing insert structures. ideal value

Method used

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  • Ocular insert apparatus and methods
  • Ocular insert apparatus and methods
  • Ocular insert apparatus and methods

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0182] Embodiments as described herein can be combined in many ways to provide an insert for prolonged placement in the eye. The length of time may depend on the use of the insert and may be at least about a week, such as a month or longer. In many embodiments, the insert can be easily placed in the eye and remain comfortably and continuously for an extended period of at least about two months, such as three months (and in many embodiments, six months or longer) . The insert can be configured and formed in many ways and can include therapeutic agents for drug delivery.

[0183] Embodiments as described herein can be used in a number of ways to simultaneously release combinations of therapeutic agents over extended periods of time. For example, a first therapeutic agent (eg, a prostaglandin) can be combined with a second therapeutic agent (eg, a beta blocker). Each therapeutic agent can be provided on a segment of the insert. The prostaglandin may include an amount less tha...

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Abstract

A comfortable insert comprises a retention structure sized for placement under the eyelids and along at least a portion of conjunctival sac of the upper and lower lids of the eye. The retention structure resists deflection when placed in the conjunctival sac of the eye and to guide the insert along the sac when the eye moves. The retention structure can be configured in many ways to provide the resistance to deflection and may comprise a hoop strength so as to urge the retention structure outward and inhibit movement of the retention structure toward the cornea. The insert may move rotationally with deflection along the conjunctival sac, and may comprise a retention structure having a cross sectional dimension sized to fit within folds of the conjunctiva.; The insert may comprise a release mechanism and therapeutic agent to release therapeutic amounts of the therapeutic agent for an extended time.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to the following co-pending U.S. Provisional Patent Applications: (1) Serial No. 61, filed September 14, 2011, entitled "Ocular Insert Apparatus And Methods" / 534,845; and (2) US Provisional Application Serial No. 61 / 568,624, filed December 8, 2011, entitled "Ocular Insert Apparatus And Methods." The disclosure of the above provisional patent application is hereby incorporated by reference in its entirety. [0003] The subject matter of this application is related to the following commonly assigned patent application: PCT Application No. PCT / US2010 / 037268, published as WO2010 / 141729 on December 9, 2010, entitled "Anterior Segment Drug Delivery"; U.S. Patent Application No. 13 / 151,001, filed June 1, 2010, entitled "Anterior Segment Drug Delivery"; and filed September 14, 2011, entitled "Ocular Insert Device and (Ocular Insert Apparatus And Methods), U.S. Provisional Patent Application Seri...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F9/00A61M31/00
CPCA61F9/0017A61K9/0051A61K47/34A61P27/02G02C7/04A61B17/00234A61L27/025A61L27/16
Inventor 小E·德胡安Y·阿尔斯特C·J·赖克K·A·麦克法兰J·章S·博伊德D·西拉J·D·亚历杭德罗D·萨顿
Owner 弗赛特影像5股份有限公司
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