629 results about "Eye drop" patented technology

The invention relates to eye drops containing exosomes and a preparation method and application thereof, and belongs to the technical field of eye drop preparation, the eye drops comprise exosome freeze-dried powder, the exosome freeze-dried powder is prepared from the exosomes obtained after mesenchymal stem cells are treated with TNF-alpha and IFN-alpha, and a herba houttuyniae extract, the eye drops provided by the invention can inhibit the phenotype of macrophage M1 and promote the M1 to be converted into the phenotype of M2; human corneal cell proliferation, migration and damage repair are promoted; mouse cornea injury repair is accelerated; the eye drops can be used for treating xerophthalmia, conjunctivitis and keratitis, and can also be used for preventing eye diseases and relieving asthenopia; the eye drops disclosed by the invention contain the exosome obtained after the mesenchymal stem cells are treated by the TNF-alpha and the IFN-alpha, so that the anti-inflammatory ability is stronger; the mesenchymal stem cell exosome and the herba houttuyniae extract are stored in a freeze-dried form, so that the activity is stable, and the storage time is long; in addition, the cordate houttuynia is cooperated with the exosome, so that the effect playing time can be prolonged, and the use frequency is reduced.

The invention discloses a liquid chromatography detection method and system for eye drops, and relates to the technical field of chromatographic detection.The liquid chromatography detection method comprises the steps that liquid chromatography analysis is conducted to obtain an original chromatographic signal; performing adaptive baseline correction on the original chromatographic signal to obtain a corrected chromatographic signal, synchronizing the corrected chromatographic signal to a chromatographic peak identification analysis model for identification to obtain a plurality of chromatographic peaks including principal component peaks and specific impurity peaks, and performing calculation to obtain a first integral area of the principal component peaks and a second integral area of the specific impurity peaks; the preset correction factor is combined with the first integral area and the second integral area to automatically carry out quantitative calculation on the eye drops, and a liquid chromatogram detection report of the eye drops is generated. The technical problems that in the prior art, main component peak and impurity peak recognition and quantification depend on manual processing in the eye drop liquid chromatogram detection process, and accuracy and consistency are insufficient are solved, and the technical effects that the accuracy and automation level of eye drop liquid chromatogram detection are improved, and it is guaranteed that main component and impurity quantification results are stable and consistent are achieved.

The invention relates to the technical field of biological medicine, in particular to eye drops containing recombinant protein as well as a preparation method and application of the eye drops. Comprising the following components: 0.01%-1% of recombinant human TFF3 protein, 0.1%-1% of an osmotic pressure regulator, 0.08%-2% of a pH regulator, 0.05%-0.15% of a thickening agent, 0.01%-0.1% of a surfactant, 0.01%-0.1% of a protective agent and the balance of water for injection, the traditional Chinese medicine composition can be used for treating the xerophthalmia, can promote wound healing and cell migration, has the effects of inhibiting inflammation and cell apoptosis, and can act on a plurality of target spots at the same time, so that the tear film stability is improved, ocular surface inflammation is inhibited, the vicious circle of the xerophthalmia is broken, and the xerophthalmia is treated more comprehensively and effectively; the problems that in the prior art, xerophthalmia medicine targets are single, and xerophthalmia cannot be comprehensively and effectively treated are solved.

The invention belongs to the technical field of microorganisms, and particularly relates to bifidobacterium animalis for relieving eye allergy and application of the bifidobacterium animalis. The invention provides an application of bifidobacterium animalis subsp. Lactis in preparation of a product for relieving eye allergy, the bifidobacterium animalis subsp. Lactis is Def +, and the preservation number is CGMCC (China General Microbiological Culture Collection Center) No.35798. The Bifidobacterium animalis subsp. Lactis Def < + > provided by the invention can relieve the eye itching symptom, relieve red and swollen eyelids, reduce conjunctiva and cornea injury, relieve eye discomfort, relieve globular conjunctivitis cell infiltration, improve corneal epithelium thickening lesion, improve the anti-inflammatory ability and improve allergic conjunctivitis, keratitis and blepharitis marginata in a targeted manner. The eye drops are high in safety and resistant to gastrointestinal fluid, and a safe and long-acting scheme is provided for eye allergic diseases.

The invention discloses a preparation method of eye drops for treating glaucoma, cataract and vitreous opacification. The eye drops comprise the following components: berberine, N-acetyl carnosine and lycium barbarum polysaccharide. The specific formula comprises the following components: 0.1%-0.5% of berberine, 1%-3% of N-acetyl carnosine and 0.5%-2% of lycium barbarum polysaccharide. The invention belongs to the technical field of ophthalmic pharmaceutical preparations, and solves the problems that in the prior art, glaucoma, cataract and vitreous opacity generally need to be separately taken, the research on compound preparations is less, and the components possibly interact with one another.

The invention relates to the field of biological medicine, in particular to a carrier-free nanoparticle which is formed by self-assembly of cyclosporine A and costunolide through intermolecular weak interaction. The invention also provides a preparation method of the traditional Chinese medicine composition and application of the traditional Chinese medicine composition in preparation of medicines for treating xerophthalmia. The carrier-free nano eye drops based on the synergistic effect of Chinese and western medicines are used for anti-inflammatory treatment of the xerophthalmia, a new strategy is provided for precise diagnosis and treatment of the xerophthalmia, the problems of single target spot, limited curative effect and the like in traditional treatment are solved, and more efficient inflammation control is expected to be achieved. While the curative effect is improved, the tolerance risk caused by long-term use is reduced, double optimization of the curative effect and safety is realized, and the limitation of traditional single drug treatment is broken through. By adopting the carrier-free nano preparation, the delivery efficiency of the medicine on the ocular surface is effectively improved, the bioavailability is enhanced, powerful support is provided for improving the curative effect of the medicine, and the carrier limitation bottleneck is broken through.

The invention relates to the technical field of pharmaceutical preparations, and provides double-shell JAK inhibitor nanoparticles, a preparation method thereof and targeted delivery eye drops. The double-shell JAK inhibitor nanoparticle provided by the invention comprises a core, an inner shell and an outer shell, wherein the core comprises a nanostructure lipid carrier and a JAK inhibitor; the inner shell layer is a cationic polymer, and the outer shell layer is hyaluronic acid. Through the design of the positive charge inner shell layer and the negative charge outer shell layer, the dual functions of mucosa adhesion and active targeting are achieved, the surface of the nanoparticle is electronegative finally, cytotoxicity possibly caused by direct exposure of a cationic polymer is reduced, non-specific aggregation of the cationic polymer and electronegative protein in tears is avoided, and the stability of tears is improved. And the stability of the preparation is improved. The eye drops provided by the invention can obviously prolong the residence time of the JAK inhibitor on the ocular surface, enhance the cornea permeability, can actively target to ocular inflammatory cells, and have a wide application prospect.

The invention relates to a near-infrared light response in-situ gelling and synergistic photo-thermal-photodynamic gel delivery system and a preparation method and application thereof, a mesoporous silicon coated up-conversion nano-carrier and an efficient photosensitizer are compounded to form a photo-response core unit, and then the photo-response core unit is intelligently integrated with photo-curing hydrogel to form the near-infrared light response in-situ gelling and synergistic photo-thermal-photodynamic gel delivery system. The general problem of aggregation and quenching of photosensitive molecules is relieved by utilizing the unique space confinement effect of the mesoporous structure, the ICG photo-thermal efficiency and photodynamic performance are enhanced, under precise excitation of a near-infrared light source, the system can activate a photo-crosslinking reaction through an up-conversion luminescence process, in-situ conversion from a liquid eye drop preparation to a stable gel state is achieved, and the stability of the eye drop preparation is improved. A lasting drug reservoir is formed on the surface of the cornea; synchronously excited photodynamic and photo-thermal dual-mode treatment generates a remarkable synergistic antibacterial effect, and shows an excellent removal capability on pathogens including highly drug-resistant bacteria; meanwhile, an ideal microenvironment is created for tissue repair through high biocompatibility and a stable mechanical matrix, and integrity recovery of cornea structures and functions is promoted.

The invention provides an eye drop composition as well as a preparation method and application thereof, and belongs to the technical field of ophthalmic preparations. The eye drop composition adopted by the invention is prepared from the following components: brimonidine tartrate, hyaluronic acid, collagen, trehalose and injection water. By compounding the components, the eye drops which can realize slow release of brimonidine tartrate and prolong the antihypertensive action time and have the characteristics of relieving blink discomfort, long-acting moisturizing, anti-inflammatory soothing, mildness, corrosion prevention and the like are prepared; the eye drops are beneficial to people suffering from glaucoma, intraocular hypertension, xerophthalmia, postoperative inflammation or allergy and preservative sensitivity or preservative allergy, the life quality is improved, and diseases are relieved.

The invention belongs to the field of pharmaceutical preparations, and particularly relates to nitrogen hydrochloride # imgabs0 # stine eye drops and a preparation process thereof, the nitrogen hydrochloride # imgabs0 # stine eye drops comprise 0.05% of nitrogen hydrochloride # imgabs1 # stine, 0.2-0.3% of hydroxypropyl methylcellulose, 0.1-0.2% of edetate disodium, 0.12-0.15% of an isoosmotic adjusting agent, 0.04-0.07% of a preservative and 0.005-0.0075% of choline aromatic folic acid; the nitrogen hydrochloride # imgabs2 # stine eye drops prepared by the preparation method disclosed by the invention have the advantages that the adsorption of nitrogen hydrochloride # imgabs3 # stine on a low-density polyethylene bottle is well inhibited under the condition of visible light, and the reduction of the concentration of nitrogen hydrochloride # imgabs4 # stine in the eye drops is remarkably prevented, so that the medication safety is improved. Besides, the added cholinofolic acid and hydroxypropyl methylcellulose have small irritation to eyes under a specific ratio, and can also have a large enough contact angle with the eyes of rabbits at high temperature, so that the retention property of the eye drops on the eyes can be improved, and the drug effect can be favorably exerted.

The invention belongs to the technical field of pharmaceutical analysis, and particularly relates to a method for detecting the content of carbomer in eye drops. The method comprises the following steps: by adopting a two-time washing and centrifugal separation mode, controlling the washing and centrifugal times, centrifugal conditions and washing volume, separating carbomer and brinzolamide from other auxiliary materials in the brinzolamide eye drops, obtaining the weights of carbomer and brinzolamide by adopting a drying and weighing mode, subtracting the weight of brinzolamide, and calculating the content of the auxiliary materials in the brinzolamide eye drops. And calculating to obtain the carbomer content in the sample. The method is suitable for detecting the carbomer content in the carbomer-containing brinzolamide eye drops, and is simple and convenient to operate, efficient, accurate and low in cost.

An eye drop propulsion device and method for propelling a drop of fluid towards an eye, including a compression chamber connected to a container configured to retain fluid, a dispenser aperture connected to the compression chamber and configured to be selectively occluded or not occluded, and a compressor configured to alter pressure in the compression chamber such that when the compressor is activated when the dispenser aperture is occluded, air is forced to flow from the compression chamber into the container, and when the compressor is deactivated, a vacuum is created in the compression chamber causing a portion of fluid in the container to flow into the compression chamber, and when the compressor is activated when the dispenser aperture is not occluded, a drop of fluid is propelled towards the eye.

The utility model discloses an anti-pollution eyedrop bottle with a positioning support. The anti-pollution eyedrop bottle comprises an anti-pollution eyedrop bottle body and the positioning support. The anti-pollution eyedrop bottle body is divided into a liquid storage area and a liquid outlet area according to the structure; the liquid storage area is cylindrical, the bottom of the liquid storage area is connected with the liquid outlet area, the liquid outlet area is conical, and a liquid outlet is formed in the bottom of the liquid outlet area; a blocking assembly and a quantifying assembly are further arranged in the anti-pollution eyedrop bottle body, the blocking assembly is used for limiting one-way circulation of liquid at the liquid outlet, and the quantifying assembly is used for ensuring constant liquid outlet every time; the outer surface of the bottom of the liquid storage area is sleeved with the positioning support, and the bottom face of the positioning support is located in the axis direction of the anti-pollution eye drop bottle body and is lower than the liquid outlet; and an isolation layer is further arranged on the outer surface of the liquid outlet and used for being isolated from the external environment. By using the device, the operation can be easily carried out, and drug use errors are avoided. Meanwhile, the sealing performance of the eyedrops in the using process is guaranteed, and pollution is reduced.

The invention discloses traditional Chinese medicine suspension eye drops and a preparation method thereof, and the traditional Chinese medicine suspension eye drops are prepared from the following raw materials in parts by weight: 1-3 parts of a traditional Chinese medicine composition, 4-7 parts of hydroxypropyl-beta-cyclodextrin, 0.5-2 parts of microcrystalline cellulose-sodium carboxymethyl cellulose and auxiliary materials. The traditional Chinese medicine suspension eye drops provided by the invention abandon a traditional eye ointment form, are directly dropped for use, are convenient to use, have good stability and dispersity, and are excellent in use curative effect and medication experience; on the basis of keeping the clinical efficacy of the Marcher eight-treasure ancient prescription, secondary development and research are scientifically carried out, so that the Marcher eight-treasure ancient prescription plays a greater clinical treatment role, and has a wider market development prospect.

The invention discloses a cassia seed antibacterial liquid for eyes and a preparation method thereof. The semen cassiae antibacterial liquid for the eyes is prepared from the following components in percentage by mass: 2.0 to 3.0 percent of semen cassiae extract, 2.0 to 3.0 percent of magnolia flower leaf extract, 2.0 to 3.0 percent of flos chrysanthemi indici extract, 2.0 to 3.0 percent of radix gentianae extract, 2.0 to 3.0 percent of flos eriocauli extract, 1.0 to 2.0 percent of radix ginseng extract, 2.0 to 3.0 percent of rhizoma polygonati extract, 1.0 to 2.0 percent of radix codonopsis extract and the balance of water. The traditional Chinese medicine composition has the beneficial effects that various eyesight-improving traditional Chinese medicine components are adopted, the traditional Chinese medicine composition does not contain any artificial hormone and antibiotic, has no toxic or side effect, has the effects of clearing liver and improving eyesight, resisting bacteria and inflammation, and improving retina microcirculation and blood flow volume, and is matched with chlorhexidine acetate, so that the traditional Chinese medicine composition has the effects of clearing liver and improving eyesight, resisting bacteria and inflammation, and improving retina microcirculation and blood flow volume. The eye drops have the advantages that the eye drops have strong inhibition effects on candida albicans, escherichia coli and staphylococcus aureus, the components of the eye drops do not contain any irritant component, irritation influence on eyes is avoided, the preparation method is simple, and the eye drops can be easily applied to large-scale production and processing processes.

The invention provides pet tear stain eye drops containing haematococcus pluvialis extract, the pH value of the eye drops is 6.8-7.2, the osmotic pressure is 280-320 mOsm / kg, the viscosity is 3-8 mPa.s (25 DEG C), and the eye drops comprise the following components in percentage by mass: 0.05-0.5% of haematococcus pluvialis astaxanthin extract (based on the astaxanthin content being greater than or equal to 5%), 0.05-0.5% of a pH regulator (based on the astaxanthin content being greater than or equal to 5%), and the balance of water. 1%-3% of an anti-inflammatory plant compound; 0.5%-1.2% of an isoosmotic adjusting agent; 0.2%-0.8% of a nano carrier stabilizer; 0.01%-0.1% of a pH buffer agent; compared with the prior art, the invention has the following beneficial effects: the corneal permeability of the astaxanthin is increased to 82% (measured by a Franz diffusion cell) through PLGA coating, and is increased by 5.5 times compared with the corneal permeability of the astaxanthin in a free state (15%); natural tocopherol is reserved through supercritical CO2 extraction (the content of the natural tocopherol is larger than or equal to 0.5% through HPLC detection), and the retention rate of the astaxanthin stored at 40 DEG C for 90 days is larger than or equal to 90% through Calendula quercitrin inhibits the expression of IL-6 (enzyme-linked immunosorbent assay (ELISA) detection is reduced by 76%), and chamomile bisabolol blocks a COX-2 pathway.

The present disclosure relates to ophthalmic compositions containing solid complexes of active pharmaceutical ingredient and cyclodextrin, to their method of preparation and their uses. The compositions can include an active agent drug / cyclodextrin complex substantially dissolved in an aqueous eye drop vehicle. The ophthalmic composition is generally in the form of a microsuspension including an active agent complex having a diameter of less than about 100 μm.

An eye drop propulsion device and method for propelling a drop of fluid towards an eye includes a compression chamber, a container configured to communicate fluid into the compression chamber, an occludable dispenser aperture, and a compressor configured to alter pressure in the compression chamber such that when the compressor is activated and the dispenser aperture is not occluded, a drop of fluid is propelled towards the eye, and when the compressor is deactivated and the dispenser aperture is occluded, a vacuum is created in the compression chamber causing fluid to flow into the compression chamber. Alternatively, the device includes a dispenser aperture connected to the compression chamber and configured to allow at least a drop to be added to the compression chamber from the container without fluid exiting the dispenser aperture, and to allow a drop of fluid to be propelled towards the eye when the compressor is activated.

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to emedastine fumarate eye drops and a preparation method thereof. The invention provides emedastine fumarate eye drops, the pH value of the emedastine fumarate eye drops is 7.2-7.6, and the emedastine fumarate eye drops are prepared from the following components in parts by weight: 0.84-0.92 part of emedastine fumarate, 2-3 parts of a thickening agent, 4.5-5.5 parts of a buffering agent, 6-8 parts of an osmotic pressure regulator, a pH regulator and 950-1050 parts of water, wherein the thickening agent is hydroxypropyl methylcellulose 2910. According to the emedastine fumarate eye drops disclosed by the invention, the hydroxypropyl methylcellulose 2910 is used as a thickening agent, so that the obtained emedastine fumarate eye drops are more clear, less in impurity content and higher in stability; meanwhile, a specific preparation method is limited, the dissolution time of the osmotic pressure regulator is greatly shortened, and the production efficiency is improved.

The invention discloses pranoprofen temperature-sensitive gel for treating xerophthalmia and a preparation method, the gel takes poloxamer 407 and poloxamer 188 as matrixes, the optimal ratio of the poloxamer 407 to the poloxamer 188 is 23.5%: 2%, and the ratio is optimized and determined by a central composite design-response surface method. During preparation, a blank gel solution is prepared firstly, and then auxiliary materials such as pranoprofen and the like are added for dissolution. The in-vitro release characteristic is good, the accumulated dissolution rate within 210 min exceeds 90%, and the zero-level pharmacokinetic process is achieved. An SD rat xerophthalmia model is established, and it is proved that the xerophthalmia treatment effect of the composition is better than that of eye drops. In eye tissue distribution and aqueous humor pharmacokinetic studies, higher target organ distribution characteristics are shown, the aqueous humor AUC0-t is 1.85 times that of eye drops, and the bioavailability is high. The invention further provides a gel preparation method, a drug effect evaluation method and a related research method, and a new effective dosage form and a new treatment thought are provided for xerophthalmia treatment.

The invention discloses a composition and a preparation method of a single-dose vitamin B12 eye drop without a bacteriostatic agent, and the single-dose vitamin B12 eye drop without the bacteriostatic agent is prepared from vitamin B12, a buffering agent, sodium hyaluronate, edetate disodium and water for injection. According to the vitamin B12 eye drops and the preparation method thereof disclosed by the invention, the vitamin B12 eye drops are produced by adopting a totally-closed sterile filling process, and a disposable single-dose packaging container is arranged, so that the sterility of medicines is ensured, and meanwhile, the use safety, the operation convenience index and the safety performance are improved.

The invention discloses a self-emulsifying nervonic acid eye drop, which is prepared from the following raw material components in percentage by mass: 1 to 10 weight percent of nervonic acid, 30 to 60 weight percent of oil phase, 20 to 40 weight percent of surfactant and 10 to 20 weight percent of co-emulsifier, the oil phase is at least one of sunflower seed oil, squalane, olive oil and castor oil. According to the invention, the oil phase rich in unsaturated fatty acid is adopted, so that the eye cream has good solubility to nervonic acid, is mild and low-sensitive, can soften the cuticle of eyes and reduce the permeation resistance of nervonic acid, and is suitable for sensitive periocular skin. The prepared self-emulsifying nervonic acid eye drops overcome the defect that nervonic acid is almost insoluble in water, and compared with water-based eye drops, the self-emulsifying nervonic acid eye drops have the advantage that the drug loading capacity and the stability are obviously improved.

The application belongs to the technical field of pharmaceutical preparations, and particularly relates to a cromolyn sodium eye drop without antioxidant. The cromolyn sodium eye drop comprises cromolyn sodium liposome and pharmaceutically acceptable additives; a formula is preferred in the preparation process of the cromolyn sodium liposome, so that the cromolyn sodium liposome has a high drug loading and encapsulation efficiency, and lays a foundation for further preparation into a preparation. In addition, the cromolyn sodium liposome eye drop of the application does not add antioxidant, and also has high stability, and is qualified in a sterile test and has high light stability.

The invention relates to the technical field of pharmaceutical preparations, and particularly discloses timolol maleate eye drops and a preparation method thereof. The timolol maleate eye drops provided by the invention are prepared from timolol maleate, glycine, trehalose, disodium hydrogen phosphate and sodium dihydrogen phosphate. According to the timolol maleate eye drops, the components of the timolol maleate eye drops are reasonably designed, and glycine and trehalose are added into the timolol maleate eye drops, so that degradation of active components of the timolol maleate eye drops is also reduced while the types and the dosage of auxiliary materials are reduced, and the eye drops have the advantages that the eye drops are safe and reliable; the stability of the timolol maleate eye drops placed for a long time is obviously improved, and the medication safety of the timolol maleate eye drops is ensured.

A composition includes an extract portion extracted from a plant selected from rosewood, myrtle, rosemary, and combinations thereof, and a carrier liquid portion. Uses of the compositions for ameliorating one or more ocular diseases and conditions are provided. Eye drop formulations containing the composition are provided.

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to pemirolast potassium eye drops and a preparation method thereof. The pemirolast potassium eye drops are composed of pemirolast potassium, hydroxypropyl ethyl cellulose, an osmotic pressure regulator, disodium hydrogen phosphate, a pH regulator and water for injection, and the prescription does not contain a bacteriostatic agent, so that the irritation of the eye drops to eye tissue cells is reduced; the pemirolast potassium eye drops provided by the invention are simple in prescription process, stable and controllable in quality and high in safety.

1. Name of the designed product: packing box (sodium hyaluronate eye drops). 2. Use of the designed product: the designed product is mainly used for packing of medicines. 3. Design points of the designed product: combination of shape and pattern. 4. Picture or photo best indicating the design points: design 1 perspective view. 5. Design 1 is designated as the basic design.

The invention relates to compound herba houttuyniae eye drops as well as a preparation method and application of the compound herba houttuyniae eye drops. Comprising the following preparation raw materials in percentage by mass: 1-6% of a herba houttuyniae extracting solution, 1-5% of an aglaia odorata extracting solution, 1-2% of a gelidium amansii extracting solution, 0.1-0.3% of acyclovir, 0.1-0.3% of tobramycin, 0.01-0.1% of dexamethasone sodium phosphate, 0.1-1% of sodium hyaluronate, 0.1-3% of glycerol and 88-93% of purified water. According to the compound herba houttuyniae eye drops prepared by the preparation method disclosed by the invention, the herba houttuyniae extracting solution, the aglaia odorata extracting solution, the gelidium amansii extracting solution, the acyclovir, the tobramycin and the dexamethasone sodium phosphate are combined for use, so that the compound herba houttuyniae eye drops have a relatively good curative effect on pets suffering from bacterium and virus mixed infection type conjunctivitis / keratitis; the compound herba houttuyniae eye drops are good in high-temperature-resistant storage stability and good in curative effect, the problem of frequent administration can be reduced, and the compound herba houttuyniae eye drops are more convenient to use and store.

The invention relates to a single-dose pilocarpine hydrochloride eye drop composition and a preparation method thereof, and belongs to the technical field of medicine preparation. The composition comprises a buffering agent, an osmotic pressure regulator and a solvent, and the composition does not contain a bacteriostatic agent. By using reasonable process preparation parameters, the prepared finished product is good in stability, the process parameters are simple and easy to operate, and the method has good application prospects and market value.

The invention discloses a pair of self-service eye drop dropping glasses which comprises a main glasses frame with a wearing function, a medicine supply part embedded in the main glasses frame is arranged on the main glasses frame, and a medicine outlet of the medicine supply part right faces eyes and is parallel to the front face of the main glasses frame. The invention further discloses a using method of the self-service eye drop dripping glasses. The problem that some patients with limited self-care ability depend on nursing of others during eye drop dispensing is solved, the purpose that automatic eye drop dispensing can be completed after the eye drop dispensing device is directly worn is achieved, and the eye drop dispensing device can be widely applied to the field of medical instruments.