441 results about "Eye drop" patented technology

The invention discloses a liquid chromatography detection method and system for eye drops, and relates to the technical field of chromatographic detection.The liquid chromatography detection method comprises the steps that liquid chromatography analysis is conducted to obtain an original chromatographic signal; performing adaptive baseline correction on the original chromatographic signal to obtain a corrected chromatographic signal, synchronizing the corrected chromatographic signal to a chromatographic peak identification analysis model for identification to obtain a plurality of chromatographic peaks including principal component peaks and specific impurity peaks, and performing calculation to obtain a first integral area of the principal component peaks and a second integral area of the specific impurity peaks; the preset correction factor is combined with the first integral area and the second integral area to automatically carry out quantitative calculation on the eye drops, and a liquid chromatogram detection report of the eye drops is generated. The technical problems that in the prior art, main component peak and impurity peak recognition and quantification depend on manual processing in the eye drop liquid chromatogram detection process, and accuracy and consistency are insufficient are solved, and the technical effects that the accuracy and automation level of eye drop liquid chromatogram detection are improved, and it is guaranteed that main component and impurity quantification results are stable and consistent are achieved.

The invention belongs to the technical field of microorganisms, and particularly relates to bifidobacterium animalis for relieving eye allergy and application of the bifidobacterium animalis. The invention provides an application of bifidobacterium animalis subsp. Lactis in preparation of a product for relieving eye allergy, the bifidobacterium animalis subsp. Lactis is Def +, and the preservation number is CGMCC (China General Microbiological Culture Collection Center) No.35798. The Bifidobacterium animalis subsp. Lactis Def < + > provided by the invention can relieve the eye itching symptom, relieve red and swollen eyelids, reduce conjunctiva and cornea injury, relieve eye discomfort, relieve globular conjunctivitis cell infiltration, improve corneal epithelium thickening lesion, improve the anti-inflammatory ability and improve allergic conjunctivitis, keratitis and blepharitis marginata in a targeted manner. The eye drops are high in safety and resistant to gastrointestinal fluid, and a safe and long-acting scheme is provided for eye allergic diseases.

The invention relates to the field of biological medicine, in particular to a carrier-free nanoparticle which is formed by self-assembly of cyclosporine A and costunolide through intermolecular weak interaction. The invention also provides a preparation method of the traditional Chinese medicine composition and application of the traditional Chinese medicine composition in preparation of medicines for treating xerophthalmia. The carrier-free nano eye drops based on the synergistic effect of Chinese and western medicines are used for anti-inflammatory treatment of the xerophthalmia, a new strategy is provided for precise diagnosis and treatment of the xerophthalmia, the problems of single target spot, limited curative effect and the like in traditional treatment are solved, and more efficient inflammation control is expected to be achieved. While the curative effect is improved, the tolerance risk caused by long-term use is reduced, double optimization of the curative effect and safety is realized, and the limitation of traditional single drug treatment is broken through. By adopting the carrier-free nano preparation, the delivery efficiency of the medicine on the ocular surface is effectively improved, the bioavailability is enhanced, powerful support is provided for improving the curative effect of the medicine, and the carrier limitation bottleneck is broken through.

The invention relates to the technical field of pharmaceutical preparations, and provides double-shell JAK inhibitor nanoparticles, a preparation method thereof and targeted delivery eye drops. The double-shell JAK inhibitor nanoparticle provided by the invention comprises a core, an inner shell and an outer shell, wherein the core comprises a nanostructure lipid carrier and a JAK inhibitor; the inner shell layer is a cationic polymer, and the outer shell layer is hyaluronic acid. Through the design of the positive charge inner shell layer and the negative charge outer shell layer, the dual functions of mucosa adhesion and active targeting are achieved, the surface of the nanoparticle is electronegative finally, cytotoxicity possibly caused by direct exposure of a cationic polymer is reduced, non-specific aggregation of the cationic polymer and electronegative protein in tears is avoided, and the stability of tears is improved. And the stability of the preparation is improved. The eye drops provided by the invention can obviously prolong the residence time of the JAK inhibitor on the ocular surface, enhance the cornea permeability, can actively target to ocular inflammatory cells, and have a wide application prospect.

The invention relates to a near-infrared light response in-situ gelling and synergistic photo-thermal-photodynamic gel delivery system and a preparation method and application thereof, a mesoporous silicon coated up-conversion nano-carrier and an efficient photosensitizer are compounded to form a photo-response core unit, and then the photo-response core unit is intelligently integrated with photo-curing hydrogel to form the near-infrared light response in-situ gelling and synergistic photo-thermal-photodynamic gel delivery system. The general problem of aggregation and quenching of photosensitive molecules is relieved by utilizing the unique space confinement effect of the mesoporous structure, the ICG photo-thermal efficiency and photodynamic performance are enhanced, under precise excitation of a near-infrared light source, the system can activate a photo-crosslinking reaction through an up-conversion luminescence process, in-situ conversion from a liquid eye drop preparation to a stable gel state is achieved, and the stability of the eye drop preparation is improved. A lasting drug reservoir is formed on the surface of the cornea; synchronously excited photodynamic and photo-thermal dual-mode treatment generates a remarkable synergistic antibacterial effect, and shows an excellent removal capability on pathogens including highly drug-resistant bacteria; meanwhile, an ideal microenvironment is created for tissue repair through high biocompatibility and a stable mechanical matrix, and integrity recovery of cornea structures and functions is promoted.

An eye drop propulsion device and method for propelling a drop of fluid towards an eye, including a compression chamber connected to a container configured to retain fluid, a dispenser aperture connected to the compression chamber and configured to be selectively occluded or not occluded, and a compressor configured to alter pressure in the compression chamber such that when the compressor is activated when the dispenser aperture is occluded, air is forced to flow from the compression chamber into the container, and when the compressor is deactivated, a vacuum is created in the compression chamber causing a portion of fluid in the container to flow into the compression chamber, and when the compressor is activated when the dispenser aperture is not occluded, a drop of fluid is propelled towards the eye.

The invention discloses traditional Chinese medicine suspension eye drops and a preparation method thereof, and the traditional Chinese medicine suspension eye drops are prepared from the following raw materials in parts by weight: 1-3 parts of a traditional Chinese medicine composition, 4-7 parts of hydroxypropyl-beta-cyclodextrin, 0.5-2 parts of microcrystalline cellulose-sodium carboxymethyl cellulose and auxiliary materials. The traditional Chinese medicine suspension eye drops provided by the invention abandon a traditional eye ointment form, are directly dropped for use, are convenient to use, have good stability and dispersity, and are excellent in use curative effect and medication experience; on the basis of keeping the clinical efficacy of the Marcher eight-treasure ancient prescription, secondary development and research are scientifically carried out, so that the Marcher eight-treasure ancient prescription plays a greater clinical treatment role, and has a wider market development prospect.

The present disclosure relates to ophthalmic compositions containing solid complexes of active pharmaceutical ingredient and cyclodextrin, to their method of preparation and their uses. The compositions can include an active agent drug / cyclodextrin complex substantially dissolved in an aqueous eye drop vehicle. The ophthalmic composition is generally in the form of a microsuspension including an active agent complex having a diameter of less than about 100 μm.

An eye drop propulsion device and method for propelling a drop of fluid towards an eye includes a compression chamber, a container configured to communicate fluid into the compression chamber, an occludable dispenser aperture, and a compressor configured to alter pressure in the compression chamber such that when the compressor is activated and the dispenser aperture is not occluded, a drop of fluid is propelled towards the eye, and when the compressor is deactivated and the dispenser aperture is occluded, a vacuum is created in the compression chamber causing fluid to flow into the compression chamber. Alternatively, the device includes a dispenser aperture connected to the compression chamber and configured to allow at least a drop to be added to the compression chamber from the container without fluid exiting the dispenser aperture, and to allow a drop of fluid to be propelled towards the eye when the compressor is activated.

The invention discloses a self-emulsifying nervonic acid eye drop, which is prepared from the following raw material components in percentage by mass: 1 to 10 weight percent of nervonic acid, 30 to 60 weight percent of oil phase, 20 to 40 weight percent of surfactant and 10 to 20 weight percent of co-emulsifier, the oil phase is at least one of sunflower seed oil, squalane, olive oil and castor oil. According to the invention, the oil phase rich in unsaturated fatty acid is adopted, so that the eye cream has good solubility to nervonic acid, is mild and low-sensitive, can soften the cuticle of eyes and reduce the permeation resistance of nervonic acid, and is suitable for sensitive periocular skin. The prepared self-emulsifying nervonic acid eye drops overcome the defect that nervonic acid is almost insoluble in water, and compared with water-based eye drops, the self-emulsifying nervonic acid eye drops have the advantage that the drug loading capacity and the stability are obviously improved.

The application belongs to the technical field of pharmaceutical preparations, and particularly relates to a cromolyn sodium eye drop without antioxidant. The cromolyn sodium eye drop comprises cromolyn sodium liposome and pharmaceutically acceptable additives; a formula is preferred in the preparation process of the cromolyn sodium liposome, so that the cromolyn sodium liposome has a high drug loading and encapsulation efficiency, and lays a foundation for further preparation into a preparation. In addition, the cromolyn sodium liposome eye drop of the application does not add antioxidant, and also has high stability, and is qualified in a sterile test and has high light stability.

The invention relates to the technical field of pharmaceutical preparations, and particularly discloses timolol maleate eye drops and a preparation method thereof. The timolol maleate eye drops provided by the invention are prepared from timolol maleate, glycine, trehalose, disodium hydrogen phosphate and sodium dihydrogen phosphate. According to the timolol maleate eye drops, the components of the timolol maleate eye drops are reasonably designed, and glycine and trehalose are added into the timolol maleate eye drops, so that degradation of active components of the timolol maleate eye drops is also reduced while the types and the dosage of auxiliary materials are reduced, and the eye drops have the advantages that the eye drops are safe and reliable; the stability of the timolol maleate eye drops placed for a long time is obviously improved, and the medication safety of the timolol maleate eye drops is ensured.

A composition includes an extract portion extracted from a plant selected from rosewood, myrtle, rosemary, and combinations thereof, and a carrier liquid portion. Uses of the compositions for ameliorating one or more ocular diseases and conditions are provided. Eye drop formulations containing the composition are provided.

1. Name of the designed product: packing box (sodium hyaluronate eye drops). 2. Use of the designed product: the designed product is mainly used for packing of medicines. 3. Design points of the designed product: combination of shape and pattern. 4. Picture or photo best indicating the design points: design 1 perspective view. 5. Design 1 is designated as the basic design.

The invention relates to compound herba houttuyniae eye drops as well as a preparation method and application of the compound herba houttuyniae eye drops. Comprising the following preparation raw materials in percentage by mass: 1-6% of a herba houttuyniae extracting solution, 1-5% of an aglaia odorata extracting solution, 1-2% of a gelidium amansii extracting solution, 0.1-0.3% of acyclovir, 0.1-0.3% of tobramycin, 0.01-0.1% of dexamethasone sodium phosphate, 0.1-1% of sodium hyaluronate, 0.1-3% of glycerol and 88-93% of purified water. According to the compound herba houttuyniae eye drops prepared by the preparation method disclosed by the invention, the herba houttuyniae extracting solution, the aglaia odorata extracting solution, the gelidium amansii extracting solution, the acyclovir, the tobramycin and the dexamethasone sodium phosphate are combined for use, so that the compound herba houttuyniae eye drops have a relatively good curative effect on pets suffering from bacterium and virus mixed infection type conjunctivitis / keratitis; the compound herba houttuyniae eye drops are good in high-temperature-resistant storage stability and good in curative effect, the problem of frequent administration can be reduced, and the compound herba houttuyniae eye drops are more convenient to use and store.

The invention discloses a pair of self-service eye drop dropping glasses which comprises a main glasses frame with a wearing function, a medicine supply part embedded in the main glasses frame is arranged on the main glasses frame, and a medicine outlet of the medicine supply part right faces eyes and is parallel to the front face of the main glasses frame. The invention further discloses a using method of the self-service eye drop dripping glasses. The problem that some patients with limited self-care ability depend on nursing of others during eye drop dispensing is solved, the purpose that automatic eye drop dispensing can be completed after the eye drop dispensing device is directly worn is achieved, and the eye drop dispensing device can be widely applied to the field of medical instruments.

1. The name of the design product: multi-dose pharmaceutical eye drop bottle (bacteria and oxygen double protection type). 2. The use of the design product: for containing eye drops, etc. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view.

The utility model provides a crystalline lens implantation postoperative nursing belt, and relates to the technical field of postoperative nursing, the crystalline lens implantation postoperative nursing belt comprises a crystalline lens implantation rear eye nursing frame, and the inner side of the crystalline lens implantation rear eye nursing frame is provided with a medicament slow release sliding frame and an eye compression sliding frame. When medicine needs to be applied, several rows of medicine slow-release sliding frames can slide into the inner side of the eye nursing frame after lens implantation, rotating baffles rotate in the sliding process of the medicine slow-release sliding frames, and after the rotating baffles rotate, medicine on the inner side of a medicine storage box can flow to the inner side of a medicine inlet pipeline through a connecting pipeline; the medicament entering pipeline is communicated with the medicament slow-release sliding frame, medicament in the medicament entering pipeline can enter from the through groove in one side of the medicament slow-release sliding frame, the medicament slow-release cotton can slowly release the medicament to the periphery of the eye, the medicament effect is continuously exerted, the inconvenience that a patient frequently uses eye drops is reduced, meanwhile, it is guaranteed that the medicament can uniformly act on the eye operation part, and the treatment effect is improved.

The present application provides compositions and methods for treatment of ocular inflammatory conditions, dry eye diseases, and abnormal corneal neovascularization, using etiprednol. In one example, a composition is provided comprising a semi-fluorinated alkane compound such as, e.g., perfluorohexyloctane; and an additive selected from paraffin, propylene glycol diacetate (PGD), a hydroxyalkyl ester of an aliphatic fatty acid, a hydroxyacid alkyl ester, an alkyl ester of a fatty acid, phenethyl alcohol, ethanol, isopropanol, glycerol, propylene glycol, polyethylene glycol, n-butanol, or combinations thereof. Eye drops comprising the compositions are also provided. Methods of using the compositions are also provided and include methods for reducing one or more symptoms of ocular inflammatory conditions, dry eye diseases, or abnormal corneal neovascularization.

The utility model discloses eye drop medicine bottle cleaning equipment which comprises a mounting plate, a power source arranged near the mounting plate, a pushing piece connected with the power source, a pushing plate arranged on the mounting plate in a sliding mode, a clamping piece arranged below the pushing plate and a containing opening formed in the pushing plate. The liquid medicine bottle is placed in the placing opening, and the water spraying holes are formed in the mounting plate; the liquid medicine bottle is fixed in the containing opening through the clamping piece, the power source pushes the pushing plate through the pushing piece, and the liquid medicine bottle is moved to the water spraying hole to be cleaned. According to the eye drop medicine bottle cleaning equipment, batch cleaning of medicine bottles is achieved, the production efficiency is improved, the cleaning effect is ensured, and the pollution risk caused by manual intervention is reduced.

The utility model provides an eye drop containing box, and belongs to the technical field of medical auxiliary instruments. Comprising a bottom plate, a frame is arranged above the bottom plate, the frame is of a hollow design, and a containing space is formed in the bottom plate; and the supporting assembly is used for supporting and fixing the frame, and the supporting assembly is connected with the bottom plate and the frame. According to the storage box, the internal space of the unfolded storage box can be separated to form a plurality of storage spaces for storing eyedrops, the storage box can be folded, a user can conveniently store the storage box or carry the storage box when going out, the use convenience effect is improved, the weakening bending part is arranged between the lower side plate and the upper side plate, and the storage box is convenient to use. The lower side plate and the upper side plate can be folded towards the inner side along the weakening and bending part, then the first side plate can be conveniently stored, the weakening and bending part can be reinforced through the arranged reinforcing plate, the weakening and bending part is prevented from being damaged after multiple times of bending, and the service life can be prolonged.

This utility model discloses a mixing tank for producing eye drops, including a tank body and a cover. The cover is fitted onto the top of the tank body. A drive motor is fixedly installed on the upper surface of the cover. A rotating rod is fixedly installed at the output end of the drive motor. The rotating rod penetrates the upper surface of the cover and extends into the interior of the tank body. A top plate is fixedly installed on the outer surface of the rotating rod. Four mounting blocks are fitted onto the outer surface of the rotating rod below the top plate. Each mounting block has a mounting plate on its four walls. This utility model, through the cooperation of components such as the tank body, cover, drive motor, rotating rod, top plate, mounting blocks, mounting plates, stirring blade, locking block, locking groove, mounting bolts, bottom plate, and pressing bolts, realizes the function of disassembling and assembling the stirring blade. It improves the fixing method of the stirring blade in the prior art, allowing for modification and replacement of the stirring blade, thus ensuring the normal use of the mixing tank and improving its practicality.

An ophthalmic composition for treating non-infectious inflammatory diseases. The ophthalmic composition comprises an active substance and an ophthalmic excipient, wherein the active substance is a JAK inhibitor; and the ophthalmic excipient comprises a pH buffer, an osmotic pressure regulator, a solubilizer, and water for injection. The ophthalmic composition is used for topical eye drop administration, is compatible and stable with eyes, can improve the bioavailability of the active substance in the ophthalmic composition, can be used for treating non-infectious inflammatory diseases, is less invasive, has small side effects, involves a simple production process, and is amenable to large-scale production.

The invention discloses difunctional nano drug-loaded eye drops for xerophthalmia and a preparation method of the difunctional nano drug-loaded eye drops, and belongs to the field of pharmaceutical preparation technologies and ophthalmology pharmacy. The core of the invention is to construct a composite nanoparticle which has a core-shell structure and has long-acting adhesion lubrication and targeted control drug release functions. The preparation method comprises the following steps: firstly, encapsulating a hydrophobic immunosuppressant such as cyclosporine A in a biodegradable pad polymer matrix such as polylactic acid-glycolic acid copolymer (PLGA) by an emulsification-solvent evaporation method to form a drug-loaded polymer nano core; through the exquisite integrated design of the structure and the function, collaborative targeted therapy of two core pathological links of'tear film instability 'and'immune inflammation' of xerophthalmia is achieved, the bioavailability of the medicine is remarkably improved, the medication frequency and eye irritation are reduced, and the curative effect of xerophthalmia is improved. A more efficient and safer administration scheme with better patient compliance is provided for clinical treatment of xerophthalmia.

The invention relates to application of graphene-(RADA-IKVAV)-pranoprofen, eye drops and a preparation method of the eye drops. The invention relates to graphene-(RADA-IKVAV)-pranoprofen, the graphene-(RADA-IKVAV)-pranoprofen comprises graphene-polyacrylic acid, self-assembled oligopeptide RADA-IKVAV and pranoprofen, the self-assembled oligopeptide RADA-IKVAV is connected with the graphene-polyacrylic acid through a chemical bond, and the pranoprofen is loaded on the surface of the graphene-polyacrylic acid. The eye drops provided by the invention comprise graphene-(RADA-IKVAV)-pranoprofen, so that the drug loading capacity of pranoprofen in the eye drops is increased, the bioavailability of drugs is improved, and the eye drops are used for inhibiting eye inflammation; the coupled oligopeptide RADA-IKVAV simulates an extracellular environment, provides a suitable microenvironment for eyes, promotes nerve repair and regeneration by influencing nerve growth factors, and promotes optic nerve repair.

The present application relates to the technical field of medicine, in particular to a kind of siRNA eye drop for penetrating mucus barrier and cell barrier and preparation method thereof.Innovative development side chain guanidino group-containing polydisulfide delivery carrier is used in the present application, through the quick dynamic disulfide exchange reaction between polydisulfide and sulfhydryl on mucin, tear film retention and efficient penetration are realized, and cationic polydisulfide is quickly adsorbed on the surface of negative charged cell membrane by electrostatic interaction, the quick dynamic disulfide exchange reaction between polydisulfide and sulfhydryl on cell membrane is used, and endocytosis is used to quickly penetrate tight junction cell layer.

The multifunctional eye drop device comprises a liquid storage bottle, a connecting cover and a protective cover, the liquid storage bottle comprises a bottle body part and a bottle opening part, a liquid storage cavity is formed in the bottle body part, a first flow guide channel is formed in the bottle opening part, the first flow guide channel is communicated with the liquid storage cavity, and the liquid storage cavity is used for storing eye drop medicine; the connecting cover comprises a cover body part and a connecting part, the cover body part is detachably connected to the bottle opening part, the connecting part is used for being connected with a needle instrument, and the connecting part is detachably connected with the needle instrument; the inner diameter of the protective cover is matched with the outer diameter of the connecting part, and the protective cover is detachably connected to the connecting part. The utility model solves the technical problem that the traditional eye drop device cannot simultaneously meet the requirements of convenient connection and sealing of the novel eye drop device and the needle due to single function.

This invention discloses a residual liquid removal structure and method for an eye dropper, comprising: a bottle body, a dropper shell, a dropper column, and an annular sealing gasket. The dropper shell is connected to the bottle body and has a flow channel. An outlet is located at the top of the flow channel, and an annular sealing gasket is located at the connection between the outlet and the flow channel. The dropper column is located within the flow channel of the dropper shell, and includes a T-shaped section and a conical section. The conical section passes through the annular sealing gasket and the outlet and extends outward from the dropper shell. The inner ring of the annular sealing gasket is sealed to the outer wall of the conical section. Several guide grooves are evenly distributed on the dropper column. The advantages of this invention are: after dispensing, releasing the bottle body pushes the liquid film adhering to the conical section of the dropper column and the liquid suspended at the end of the conical section away from the conical section, allowing it to be dispensed into the user's eye without waste. Furthermore, it keeps the conical section exposed to air dry, thus preventing bacterial growth.

The invention belongs to the technical field of medical instruments, and provides a long-acting moisturizing contact lens eye lotion and a preparation method thereof. The contact lens eye moistening liquid provided by the invention is prepared from the following components in parts by mass: 0.01 to 0.5 part of gamma-polyglutamic acid, 0.5 to 1.2 parts of electrolyte component, 0.1 to 1.0 part of osmotic pressure regulator, 0.01 to 0.1 part of poloxamer 407 and 96 to 99.5 parts of buffer solution. According to the contact lens eye lotion disclosed by the invention, long-acting moisturizing, low irritation, high stability and excellent lens compatibility are realized through structural synergy of the polyglutamic acid and the electrolyte, functional synergy of the polyglutamic acid and the preservative and environmental synergy of the buffer solution and the osmotic pressure regulator, and the physiological function of natural tears is simulated.