251 results about "Eye drop" patented technology

The invention discloses a liquid chromatography detection method and system for eye drops, and relates to the technical field of chromatographic detection.The liquid chromatography detection method comprises the steps that liquid chromatography analysis is conducted to obtain an original chromatographic signal; performing adaptive baseline correction on the original chromatographic signal to obtain a corrected chromatographic signal, synchronizing the corrected chromatographic signal to a chromatographic peak identification analysis model for identification to obtain a plurality of chromatographic peaks including principal component peaks and specific impurity peaks, and performing calculation to obtain a first integral area of the principal component peaks and a second integral area of the specific impurity peaks; the preset correction factor is combined with the first integral area and the second integral area to automatically carry out quantitative calculation on the eye drops, and a liquid chromatogram detection report of the eye drops is generated. The technical problems that in the prior art, main component peak and impurity peak recognition and quantification depend on manual processing in the eye drop liquid chromatogram detection process, and accuracy and consistency are insufficient are solved, and the technical effects that the accuracy and automation level of eye drop liquid chromatogram detection are improved, and it is guaranteed that main component and impurity quantification results are stable and consistent are achieved.

The invention belongs to the technical field of microorganisms, and particularly relates to bifidobacterium animalis for relieving eye allergy and application of the bifidobacterium animalis. The invention provides an application of bifidobacterium animalis subsp. Lactis in preparation of a product for relieving eye allergy, the bifidobacterium animalis subsp. Lactis is Def +, and the preservation number is CGMCC (China General Microbiological Culture Collection Center) No.35798. The Bifidobacterium animalis subsp. Lactis Def < + > provided by the invention can relieve the eye itching symptom, relieve red and swollen eyelids, reduce conjunctiva and cornea injury, relieve eye discomfort, relieve globular conjunctivitis cell infiltration, improve corneal epithelium thickening lesion, improve the anti-inflammatory ability and improve allergic conjunctivitis, keratitis and blepharitis marginata in a targeted manner. The eye drops are high in safety and resistant to gastrointestinal fluid, and a safe and long-acting scheme is provided for eye allergic diseases.

An eye drop propulsion device and method for propelling a drop of fluid towards an eye, including a compression chamber connected to a container configured to retain fluid, a dispenser aperture connected to the compression chamber and configured to be selectively occluded or not occluded, and a compressor configured to alter pressure in the compression chamber such that when the compressor is activated when the dispenser aperture is occluded, air is forced to flow from the compression chamber into the container, and when the compressor is deactivated, a vacuum is created in the compression chamber causing a portion of fluid in the container to flow into the compression chamber, and when the compressor is activated when the dispenser aperture is not occluded, a drop of fluid is propelled towards the eye.

The invention discloses traditional Chinese medicine suspension eye drops and a preparation method thereof, and the traditional Chinese medicine suspension eye drops are prepared from the following raw materials in parts by weight: 1-3 parts of a traditional Chinese medicine composition, 4-7 parts of hydroxypropyl-beta-cyclodextrin, 0.5-2 parts of microcrystalline cellulose-sodium carboxymethyl cellulose and auxiliary materials. The traditional Chinese medicine suspension eye drops provided by the invention abandon a traditional eye ointment form, are directly dropped for use, are convenient to use, have good stability and dispersity, and are excellent in use curative effect and medication experience; on the basis of keeping the clinical efficacy of the Marcher eight-treasure ancient prescription, secondary development and research are scientifically carried out, so that the Marcher eight-treasure ancient prescription plays a greater clinical treatment role, and has a wider market development prospect.

An eye drop propulsion device and method for propelling a drop of fluid towards an eye includes a compression chamber, a container configured to communicate fluid into the compression chamber, an occludable dispenser aperture, and a compressor configured to alter pressure in the compression chamber such that when the compressor is activated and the dispenser aperture is not occluded, a drop of fluid is propelled towards the eye, and when the compressor is deactivated and the dispenser aperture is occluded, a vacuum is created in the compression chamber causing fluid to flow into the compression chamber. Alternatively, the device includes a dispenser aperture connected to the compression chamber and configured to allow at least a drop to be added to the compression chamber from the container without fluid exiting the dispenser aperture, and to allow a drop of fluid to be propelled towards the eye when the compressor is activated.

The invention relates to the technical field of pharmaceutical preparations, and particularly discloses timolol maleate eye drops and a preparation method thereof. The timolol maleate eye drops provided by the invention are prepared from timolol maleate, glycine, trehalose, disodium hydrogen phosphate and sodium dihydrogen phosphate. According to the timolol maleate eye drops, the components of the timolol maleate eye drops are reasonably designed, and glycine and trehalose are added into the timolol maleate eye drops, so that degradation of active components of the timolol maleate eye drops is also reduced while the types and the dosage of auxiliary materials are reduced, and the eye drops have the advantages that the eye drops are safe and reliable; the stability of the timolol maleate eye drops placed for a long time is obviously improved, and the medication safety of the timolol maleate eye drops is ensured.

A composition includes an extract portion extracted from a plant selected from rosewood, myrtle, rosemary, and combinations thereof, and a carrier liquid portion. Uses of the compositions for ameliorating one or more ocular diseases and conditions are provided. Eye drop formulations containing the composition are provided.

1. Name of the designed product: packing box (sodium hyaluronate eye drops). 2. Use of the designed product: the designed product is mainly used for packing of medicines. 3. Design points of the designed product: combination of shape and pattern. 4. Picture or photo best indicating the design points: design 1 perspective view. 5. Design 1 is designated as the basic design.

The utility model provides a crystalline lens implantation postoperative nursing belt, and relates to the technical field of postoperative nursing, the crystalline lens implantation postoperative nursing belt comprises a crystalline lens implantation rear eye nursing frame, and the inner side of the crystalline lens implantation rear eye nursing frame is provided with a medicament slow release sliding frame and an eye compression sliding frame. When medicine needs to be applied, several rows of medicine slow-release sliding frames can slide into the inner side of the eye nursing frame after lens implantation, rotating baffles rotate in the sliding process of the medicine slow-release sliding frames, and after the rotating baffles rotate, medicine on the inner side of a medicine storage box can flow to the inner side of a medicine inlet pipeline through a connecting pipeline; the medicament entering pipeline is communicated with the medicament slow-release sliding frame, medicament in the medicament entering pipeline can enter from the through groove in one side of the medicament slow-release sliding frame, the medicament slow-release cotton can slowly release the medicament to the periphery of the eye, the medicament effect is continuously exerted, the inconvenience that a patient frequently uses eye drops is reduced, meanwhile, it is guaranteed that the medicament can uniformly act on the eye operation part, and the treatment effect is improved.

The present application provides compositions and methods for treatment of ocular inflammatory conditions, dry eye diseases, and abnormal corneal neovascularization, using etiprednol. In one example, a composition is provided comprising a semi-fluorinated alkane compound such as, e.g., perfluorohexyloctane; and an additive selected from paraffin, propylene glycol diacetate (PGD), a hydroxyalkyl ester of an aliphatic fatty acid, a hydroxyacid alkyl ester, an alkyl ester of a fatty acid, phenethyl alcohol, ethanol, isopropanol, glycerol, propylene glycol, polyethylene glycol, n-butanol, or combinations thereof. Eye drops comprising the compositions are also provided. Methods of using the compositions are also provided and include methods for reducing one or more symptoms of ocular inflammatory conditions, dry eye diseases, or abnormal corneal neovascularization.

The utility model discloses eye drop medicine bottle cleaning equipment which comprises a mounting plate, a power source arranged near the mounting plate, a pushing piece connected with the power source, a pushing plate arranged on the mounting plate in a sliding mode, a clamping piece arranged below the pushing plate and a containing opening formed in the pushing plate. The liquid medicine bottle is placed in the placing opening, and the water spraying holes are formed in the mounting plate; the liquid medicine bottle is fixed in the containing opening through the clamping piece, the power source pushes the pushing plate through the pushing piece, and the liquid medicine bottle is moved to the water spraying hole to be cleaned. According to the eye drop medicine bottle cleaning equipment, batch cleaning of medicine bottles is achieved, the production efficiency is improved, the cleaning effect is ensured, and the pollution risk caused by manual intervention is reduced.

The utility model provides an eye drop containing box, and belongs to the technical field of medical auxiliary instruments. Comprising a bottom plate, a frame is arranged above the bottom plate, the frame is of a hollow design, and a containing space is formed in the bottom plate; and the supporting assembly is used for supporting and fixing the frame, and the supporting assembly is connected with the bottom plate and the frame. According to the storage box, the internal space of the unfolded storage box can be separated to form a plurality of storage spaces for storing eyedrops, the storage box can be folded, a user can conveniently store the storage box or carry the storage box when going out, the use convenience effect is improved, the weakening bending part is arranged between the lower side plate and the upper side plate, and the storage box is convenient to use. The lower side plate and the upper side plate can be folded towards the inner side along the weakening and bending part, then the first side plate can be conveniently stored, the weakening and bending part can be reinforced through the arranged reinforcing plate, the weakening and bending part is prevented from being damaged after multiple times of bending, and the service life can be prolonged.

This utility model discloses a mixing tank for producing eye drops, including a tank body and a cover. The cover is fitted onto the top of the tank body. A drive motor is fixedly installed on the upper surface of the cover. A rotating rod is fixedly installed at the output end of the drive motor. The rotating rod penetrates the upper surface of the cover and extends into the interior of the tank body. A top plate is fixedly installed on the outer surface of the rotating rod. Four mounting blocks are fitted onto the outer surface of the rotating rod below the top plate. Each mounting block has a mounting plate on its four walls. This utility model, through the cooperation of components such as the tank body, cover, drive motor, rotating rod, top plate, mounting blocks, mounting plates, stirring blade, locking block, locking groove, mounting bolts, bottom plate, and pressing bolts, realizes the function of disassembling and assembling the stirring blade. It improves the fixing method of the stirring blade in the prior art, allowing for modification and replacement of the stirring blade, thus ensuring the normal use of the mixing tank and improving its practicality.

An ophthalmic composition for treating non-infectious inflammatory diseases. The ophthalmic composition comprises an active substance and an ophthalmic excipient, wherein the active substance is a JAK inhibitor; and the ophthalmic excipient comprises a pH buffer, an osmotic pressure regulator, a solubilizer, and water for injection. The ophthalmic composition is used for topical eye drop administration, is compatible and stable with eyes, can improve the bioavailability of the active substance in the ophthalmic composition, can be used for treating non-infectious inflammatory diseases, is less invasive, has small side effects, involves a simple production process, and is amenable to large-scale production.

The invention discloses difunctional nano drug-loaded eye drops for xerophthalmia and a preparation method of the difunctional nano drug-loaded eye drops, and belongs to the field of pharmaceutical preparation technologies and ophthalmology pharmacy. The core of the invention is to construct a composite nanoparticle which has a core-shell structure and has long-acting adhesion lubrication and targeted control drug release functions. The preparation method comprises the following steps: firstly, encapsulating a hydrophobic immunosuppressant such as cyclosporine A in a biodegradable pad polymer matrix such as polylactic acid-glycolic acid copolymer (PLGA) by an emulsification-solvent evaporation method to form a drug-loaded polymer nano core; through the exquisite integrated design of the structure and the function, collaborative targeted therapy of two core pathological links of'tear film instability 'and'immune inflammation' of xerophthalmia is achieved, the bioavailability of the medicine is remarkably improved, the medication frequency and eye irritation are reduced, and the curative effect of xerophthalmia is improved. A more efficient and safer administration scheme with better patient compliance is provided for clinical treatment of xerophthalmia.

The invention relates to application of graphene-(RADA-IKVAV)-pranoprofen, eye drops and a preparation method of the eye drops. The invention relates to graphene-(RADA-IKVAV)-pranoprofen, the graphene-(RADA-IKVAV)-pranoprofen comprises graphene-polyacrylic acid, self-assembled oligopeptide RADA-IKVAV and pranoprofen, the self-assembled oligopeptide RADA-IKVAV is connected with the graphene-polyacrylic acid through a chemical bond, and the pranoprofen is loaded on the surface of the graphene-polyacrylic acid. The eye drops provided by the invention comprise graphene-(RADA-IKVAV)-pranoprofen, so that the drug loading capacity of pranoprofen in the eye drops is increased, the bioavailability of drugs is improved, and the eye drops are used for inhibiting eye inflammation; the coupled oligopeptide RADA-IKVAV simulates an extracellular environment, provides a suitable microenvironment for eyes, promotes nerve repair and regeneration by influencing nerve growth factors, and promotes optic nerve repair.

The present application relates to the technical field of medicine, in particular to a kind of siRNA eye drop for penetrating mucus barrier and cell barrier and preparation method thereof.Innovative development side chain guanidino group-containing polydisulfide delivery carrier is used in the present application, through the quick dynamic disulfide exchange reaction between polydisulfide and sulfhydryl on mucin, tear film retention and efficient penetration are realized, and cationic polydisulfide is quickly adsorbed on the surface of negative charged cell membrane by electrostatic interaction, the quick dynamic disulfide exchange reaction between polydisulfide and sulfhydryl on cell membrane is used, and endocytosis is used to quickly penetrate tight junction cell layer.

The multifunctional eye drop device comprises a liquid storage bottle, a connecting cover and a protective cover, the liquid storage bottle comprises a bottle body part and a bottle opening part, a liquid storage cavity is formed in the bottle body part, a first flow guide channel is formed in the bottle opening part, the first flow guide channel is communicated with the liquid storage cavity, and the liquid storage cavity is used for storing eye drop medicine; the connecting cover comprises a cover body part and a connecting part, the cover body part is detachably connected to the bottle opening part, the connecting part is used for being connected with a needle instrument, and the connecting part is detachably connected with the needle instrument; the inner diameter of the protective cover is matched with the outer diameter of the connecting part, and the protective cover is detachably connected to the connecting part. The utility model solves the technical problem that the traditional eye drop device cannot simultaneously meet the requirements of convenient connection and sealing of the novel eye drop device and the needle due to single function.

This invention discloses a residual liquid removal structure and method for an eye dropper, comprising: a bottle body, a dropper shell, a dropper column, and an annular sealing gasket. The dropper shell is connected to the bottle body and has a flow channel. An outlet is located at the top of the flow channel, and an annular sealing gasket is located at the connection between the outlet and the flow channel. The dropper column is located within the flow channel of the dropper shell, and includes a T-shaped section and a conical section. The conical section passes through the annular sealing gasket and the outlet and extends outward from the dropper shell. The inner ring of the annular sealing gasket is sealed to the outer wall of the conical section. Several guide grooves are evenly distributed on the dropper column. The advantages of this invention are: after dispensing, releasing the bottle body pushes the liquid film adhering to the conical section of the dropper column and the liquid suspended at the end of the conical section away from the conical section, allowing it to be dispensed into the user's eye without waste. Furthermore, it keeps the conical section exposed to air dry, thus preventing bacterial growth.

The application discloses an eye preparation composition for treating presbyopia with longer action time and fewer adverse reactions and a preparation method thereof. The composition contains pilocarpine with a mass volume percentage of 0.42-1.02% (equivalent to 0.50-1.20% of hydrochloric acid pilocarpine and 0.55-1.33% of nitric acid pilocarpine), sodium carboxymethylcellulose with a mass percentage of 0.03-0.3%, hydroxyethyl p-henyl-ethyl ester with a mass percentage of 0.03-0.06%, and sodium chloride with a mass percentage of 0.6-0.8%. The prepared pilocarpine eye drops have the advantages of effectively enhancing the corneal permeability of pilocarpine, prolonging the retention time of the eye drops in eyes, reducing the use frequency while improving the pilocarpine miosis effect and treating presbyopia, reducing the irritation and damage of pilocarpine to corneas, and reducing the incidence of systemic adverse reactions compared with the related preparations on the market. In addition, the prescription pH value of the application is 4.0-5.0, which can effectively reduce the generation of impurities such as pilocarpine acid and ensure the product quality in the whole life cycle.

The utility model discloses a pranoprofen eye drop quantitative filling device, which relates to the technical field of eye drop filling, and comprises a filling pipe and a quantitative component, the lower end of the filling pipe is connected with a quantitative pipe, the front side of the quantitative pipe is provided with an observation window, the quantitative component for quantitative filling is arranged in the quantitative pipe, and the observation window is arranged on the front side of the quantitative pipe. And the quantitative assembly comprises an inner mounting frame, a protection pipe, a hydraulic rod, a top partition plate, a connecting rod and a bottom partition plate, the protection pipe is installed in the middle of the lower end of the inner mounting frame, the hydraulic rod is arranged in the protection pipe, and the output end of the hydraulic rod is connected with the top partition plate. According to the quantitative filling device for the pranoprofen eye drops, the inner sides of the top partition plate and the bottom partition plate play a quantitative liquid separation role on the eye drops, when the bottom partition plate further moves downwards to exceed the bottom of the quantitative tube, the quantitative eye drops are filled through the filling head, and at the moment, the top partition plate plays a separation role on the eye drops in the liquid storage box in the quantitative tube; the eye drops are prevented from being polluted.

The utility model provides a two-way connecting cover which is used for guiding liquid medicine and comprises an integrally-formed cover body, the cover body comprises a connecting part and a functional part, and the bottom of the functional part extends outwards and downwards to form the connecting part; the connecting part comprises a first shell and a connecting inner column, the top of the first shell extends downwards to form the connecting inner column, the connecting inner column is arranged in the first shell, and a first flow guide channel is formed in the connecting inner column; the functional part comprises a second shell and a liquid outlet pipe arranged in the second shell, the horizontal height of a liquid outlet of the liquid outlet pipe is higher than the horizontal height of the top of the second shell, and a liquid outlet channel and a liquid collecting cavity are formed in the liquid outlet pipe from top to bottom; and the first flow guide channel, the liquid gathering cavity and the liquid outlet channel are communicated in sequence. The eyedrop bottle cap solves the technical problems that a traditional eyedrop bottle cap is single in structure and poor in flow guide effect.

1. Name of the product in this design: Packaging Box (Taurine Eye Drops). 2. Purpose of this design: For packaging eye drops. 3. The key design features of this product are the combination of shape and pattern. 4. The image or photograph that best illustrates the design's key points: a 3D model.

The utility model relates to the technical field of auxiliary medical instruments, and discloses a foldable eyedrop dripping assist device which comprises a fixing box, a connecting assembly is arranged on the upper surface of the fixing box, and a clamping assembly is arranged in the fixing box. The connecting assembly comprises a hinge, a supporting cover is arranged on the side wall of the fixing box, one side of the hinge is fixedly connected to the side wall of the fixing box, the other side of the hinge is fixedly connected to the side wall of the supporting cover, a rubber pad is fixedly connected to the side wall of the supporting cover, a first neodymium iron boron magnet is fixedly connected into the supporting cover, and a second neodymium iron boron magnet is fixedly connected into the first neodymium iron boron magnet. A second neodymium iron boron magnet is fixedly connected into the fixing box, the clamping assembly comprises a rubber plate, and the rubber plate is arranged in the fixing box. According to the auxiliary device, the supporting cover is unfolded through rotation of the hinge, the first neodymium iron boron magnet and the second neodymium iron boron magnet attract to lock the position, the rubber pad is matched to make contact with eyelids to provide friction force, the problem that a traditional auxiliary device is inconvenient to store is solved, and the using stability of the auxiliary device is improved.

The invention relates to the technical field of medical supplies, in particular to an anti-pollution eyedrop instillation device and a using method thereof.The anti-pollution eyedrop instillation device comprises a disposable sterile sleeve, and the disposable sterile sleeve is detachably connected with a bottle opening of an eyedrop bottle; two ports of the disposable sterile sleeve are communicated with each other, one port is a liquid outlet, and the other port is detachably connected with a bottle opening of the eyedrop bottle in a sealing manner; a non-return device is arranged in the disposable sterile sleeve and can prevent liquid from flowing from one end of the liquid outlet to one end connected with a bottle opening of the eye drop bottle. The secondary pollution of the eyedrop bottle opening is physically eradicated, the sterility of the eyedrop is guaranteed, and the eyedrop bottle is suitable for all scenes needing to strictly avoid cross infection.

This invention provides an eyelid-opening eye drop device. The eyelid-opening eye drop device includes an eyelid-separating assembly, a main body, a drug applicator, and a control assembly. The eyelid-separating assembly, located at one end of the main body, includes a first eyelid-separating ball and a second eyelid-separating ball, respectively connected to the main body via a first axis and a second axis. The first eyelid-separating ball is rotatable around the first axis, and the second eyelid-separating ball is rotatable around the second axis. When the eyelid-opening assembly opens the eyelid and the drug applicator is aligned with a preset area of ​​the eyeball, the drug applicator releases a preset dose of eye drops.

The invention relates to a preparation method of brimonidine tartrate eye drops, particularly relates to a new technical scheme obtained by adjusting the rotating speed, the temperature and the material adding sequence, and solves the problems of non-uniform content of benzalkonium chloride and dissolution of polyvinyl alcohol. The brimonidine tartrate eye drops prepared by the preparation method disclosed by the invention are uniform in benzalkonium chloride content, clear in liquid medicine, stable in quality, low in requirements on production equipment and suitable for large-scale industrial production.

This invention relates to a sustained-release eye drop and its preparation method, belonging to the field of ophthalmic drug technology. The invention provides a self-assembled microparticle comprising an elastin-like peptide and sodium hyaluronate; the molar ratio of the elastin-like peptide to sodium hyaluronate is 5-7:1-2; the amino acid sequence of the elastin-like peptide is shown in SEQ ID NO.1. The self-assembled microparticles of this invention have a sustained-release effect and exhibit synergistic properties with hydroxypropyl methylcellulose. The eye drops prepared by combining these two components possess excellent sustained-release performance, adhesion, and stability, allowing for prolonged application to the eye, effectively solving the problem of short duration of action in existing eye drops.

The utility model relates to eye drop bottle mould technical field discloses a mould suitable for adapting different specifications different shape's eye drop bottle, including frame, the inside of frame is provided with adjusting mechanism, adjusting mechanism is used for adjusting the height and diameter of mould production area, the top fixedly connected with casing of frame, the inside of casing is provided with fixed mechanism, and fixed mechanism is used for clamping different size's mould, adjusting mechanism includes injection mould shell, the outside wall of injection mould shell is fixedly connected with the inside of frame, the inner wall slidingly connected of injection mould shell has nested sliding shell. In the utility model, servo motor no.