82 results about "Cetirizine Hydrochloride" patented technology

Pharmacological test shows that the externally-used preparation of Cetirizine has ideal allergy resistant and anti-inflammatory action to the rat passive cutaneous anaphylaxis (Rat PCA) model and dimethylbenzene caused mouse otitis model, and also prevents the adverse effect to the central system caused by whole body administration. It is also found in the test, that the externally used preparation of Cetirizine also has very fine inhibitory action to dinitrofluorobenzene caused mouse porphyria hypersensitivity (PTH), the novel pharmacological action of the Cetirizine shows that the Cetirizine external preparation has good therapeutic action to skin inflammations which mainly include porphyria hypersensitivity.

The invention discloses a cetirizine hydrochloride tablet and a preparation method thereof. The preparation method of the cetirizine hydrochloride tablet comprises the following steps of: dissolving hydroxy propyl cellulose and cetirizine hydrochloride in alcohol, adding blank pellets and slowly adhering the main drug which is coated by the hydroxy propyl cellulose on the surfaces of the pellets in a slow solvent removal process; and uniformly mixing the drug-carrying pellets and pharmaceutically acceptable auxiliary materials and directly tabletting the mixture to form the cetirizine hydrochloride tablet. According to the preparation method of the cetirizine hydrochloride tablet disclosed by the invention, the cetirizine hydrochloride can be prevented from directly contacting with the external environment, so that a preparation device corrosion problem caused by strong drug acidity during a preparation production process can be avoided.

The invention discloses a cetirizine hydrochloride oral solution, which comprises cetirizine hydrochloride, mannitol, hydroxy propyl cellulose and water. The oral solution provided by the invention effectively covers up the strong titter taste of the active component cetirizine, obviously improves the stability of the oral solution, effectively reduces the chemical degradation and the toxic or side effects of the cetirizine, reduces the molecular aggregation phenomenon of the active component, reduces the using risk and improves the medicine safety.

The invention relates to a hydrochloric acid levocetirizine orally disintegrating tablet and a preparation method thereof. The hydrochloric acid levocetirizine orally disintegrating tablet is obtained by directly pressing principal medicine and accessories. The tablet of the invention can be dissolved fast in a mouth cavity and has no grit feeling and high biological availability, which takes effect fast and can have curative effect faster.

The invention provides a preparation method of cetirizine hydrochloride with high purity. The method comprises: 4-[(4-chlorophenyl) phenyl]-1-hydroxyethyl piperazine and sodium chloroacetate are used as reaction substrates and alkali metal hydroxide is used as catalyst for the condensation reaction in organic solvent at 5-40 DEG C; when the condensation reaction is finished, cetirizine mother nucleus compounds obtained after the reaction are separated and the salt-forming reaction is carried out between the cetirizine mother nucleus compounds and hydrogen chloride gas. The cetirizine hydrochloride is obtained. The method of the invention has the advantages of simple technical process, easily obtained raw materials, safe operation, little produced three wastes and high purity of obtained cetirizine hydrochloride products and satisfies standards of British pharmacopeia and European pharmacopoeia.

The invention provides cetirizine hydrochloride syrup. The syrup comprises cetirizine hydrochloride, sodium glutamate, xanthan gum, saccharose, a pH regulator, a flavoring agent and water, wherein the weight ratio of cetirizine hydrochloride to xanthan gum is 1:(1-10), preferably 1:5; the using amount of sodium glutamate accounts for 0.5-1.0 percent of the total weight of the syrup; the pH regulator is a disodium hydrogen phosphate-citric acid buffer solution; and the flavoring agent is aspartame, steviosin or sodium saccharin. The cetirizine hydrochloride syrup has excellent taste, stable property and simple preparation process.

The invention relates to a cetirizine hydrochloride pseudo ephedrine sustained-release pellet. The cetirizine hydrochloride pseudo ephedrine sustained-release pellet comprises a medicated pellet body and a coating layer; the coating layer wraps the medicated pellet body; the medicated pellet body comprises 5 mg of cetirizine hydrochloride, 125 mg of pseudoephedrine hydrochloride, 80 mg of core pellets, 100-200 mg of fillers, 25-125 mg of lubricating agents and 5-50 mg of binding agents; the coating layer comprises 45-225 mg of Eudragit NE30D and 14-68 mg of talcum powder; the preparation method includes the steps that (1) material preparing; (2) mixing; (3) binding agent preparing; (4) pelleting; (5) coating material preparing, (6) coating; (7) filling; and (8) conducting aluminum plastic and obtaining end products. The cetirizine hydrochloride pseudo ephedrine sustained-release pellet is used for remitting nasal symptoms or non-nasal symptoms caused by perennial or seasonal anaphylactic rhinitis; a novel sustained release preparation and a novel pellet preparation are adopted, the treatment effect is stable, and the bioavailability is higher.

The present invention relates to medicine technology and is cataplasm as one new form of Cetirizine hydrochloride. There are available oral forms of Cetirizine hydrochloride, such as tablet, capsule, solution preparation, etc. The present invention prepares the cataplasm with Cetirizine hydrochloride as main medicine component and different supplementary material, and the cataplasm is administrated via skin. The present invention can avoid stimulation to gastrointestinal tract of the medicine, reduce medicine concentration in blood, reduce central nerve suppressing effect, raise the medicine concentration in local affected part, decrease the administration times and raise patient's compatibility.

The invention belongs to the field of medicines, in particular to an external preparation of cetirizine hydrochloride, i.e., cetirizine hydrochloride liniment. Aiming at the defects of poor tissue infiltration capacity, limited dosage reaching target positions, and the like existed in the prior external preparation of cetirizine hydrochloride, the invention provides the cetirizine hydrochloride liniment with more remarkable antianaphylaxis healing effect by optimizing a prescription and screening more suitable accessories in an experiment process according to the physicochemical property of the cetirizine hydrochloride. The cetirizine hydrochloride liniment provided by the invention has simple preparation process and lower cost, little skin irritation and favorable treatment effect on partial skin redness and pruritus caused by mosquito bites.

The invention provides a method for detecting relavant substances of cetirizine hydrochloride granules. The detection method is characterized in that a phenyl column is adopted, the phenyl column is an Agilent Eclipse XDB phenyl 5-micrometer chromatographic column in the area of 4.6mm*250mm; a mixed solution of acetonitrile and ammonium acetate buffer solution in a volume ratio of (2: 8) to (4: 6) is adopted as a flow phase, isocratic elution is carried out on a high-efficiency liquid phase chromatographic instrument, and the relevant substances of the cetirizine hydrochloride granules are detected by utilizing an ultraviolet detector. The detection method is good in sensitivity, specificity, precision and accuracy, simple to operate and suitable for detecting relevant substances of the cetirizine hydrochloride granules.

The invention relates to a cetirizine pseudoephedrine sustained-release capsule preparation. The interior of the capsule is provided with two tablets with different drug releasing speeds, namely, the cetirizine hydrochloride immediate-release tablet and the pseudoephedrine hydrochloride sustained-release tablet. The preparation has simple preparation process, and the ordinary tablet press machine can complete the process by only one time of tablet pressing; when taken, the cetirizine hydrochloride and the pseudoephedrine hydrochloride can be released simultaneously, so as to better achieve the purpose of combined treatment.

The invention discloses a cetirizine hydrochloride tablet and a preparation method thereof, and belongs to the field of chemical medicine preparations. The cetirizine hydrochloride tablet is characterized in that cetirizine hydrochloride is prepared into pellets, and the pellets are coated, so as to prepare the tablet. The cetirizine hydrochloride tablet has the advantages that the sticking is avoided, and the release of the medicine is stable.

The invention provides a cetirizine hydrochloride soft capsule and a preparation method thereof. The cetirizine hydrochloride soft capsule comprises a capsule shell and content, wherein the capsule shell is prepared from gelatin, glycerinum, sorbitol and water; the content is prepared from cetirizine hydrochloride, buffer salt, polyethylene glycol and water. The cetirizine hydrochloride soft capsule has the advantages of good stability, little impurity production, relatively long acting period and few potential adverse responses, and is convenient to transport and store.

The invention relates to a preparation for treating allergic rhinitis. The preparation is prepared by pressing a quick release layer and a sustained-release layer into bilayer tablets and coating, wherein the quick release layer consists of the following components in percentage by mass: 1 to 10 percent of levocetirizine hydrochloride, 1 to 15 percent of disintegrating agent, 0.5 to 3 percent of lubricating agent, 0 to 8 percent of adhesive and the balance of filler; the sustained-release layer consists of the following components in percentage by mass: 20 to 30 percent of pseudoephedrine hydrochloride, 50 to 60 percent of sustained-release framework material, 0.5 to 3 percent of lubricating agent, 0 to 8 percent of adhesive and the balance of filler; and the mass ratio of the levocetirizine hydrochloride to the pseudoephedrine hydrochloride is 1:48. The sustained-release tablets for treating the allergic rhinitis have bright and clean surfaces, and the release behavior of the main medicine pseudoephedrine hydrochloride of the sustained-release tablets has high consistency with that of American marketed medicine cetirizine hydrochloride and pseudoephedrine hydrochloride sustained-release tablets through detection; and the dissolution rate of the main medicine levocetirizine hydrochloride of the sustained-release tablets in 30 minutes is over 90 percent, so that the sustained-release preparation for treating the allergic rhinitis has high bioavailability, a good absorption effect, comprehensive and effective clinical curative effects, small side effects and ideal safety.

The invention discloses cetirizine hydrochloride ophthalmic liposome, in-situ gel and a preparation method of cetirizine hydrochloride ophthalmic liposome, and belongs to the technical field of pharmaceutical preparations. In order to overcome the defects that existing cetirizine hydrochloride eye drops are short in residence time, poor in compliance of semi-solid dosage forms, low in bioavailability, not easy to accept by patients and the like, an ethanol injection method is combined with an ammonium sulfate gradient method to obtain the liposome, and the liposome comprises 0.28-0.30% of cetirizine hydrochloride, 1.4-6.0% of phospholipid, 0.14-1.8% of cholesterol, 0.1-0.15% of an osmotic pressure regulator, 0.05-0.1% of a bacteriostatic agent and the balance of water. And a solvent. The invention further provides the cetirizine hydrochloride liposome-in-situ gel and a preparation method thereof. By optimizing the prescription and the process, the obtained liposome and in-situ gel can delay the drug release, increase the retention time of eyes, improve the cornea permeability and improve the bioavailability.

The invention relates to the technical field of pharmaceutical solid oral preparations and specifically relates to a cetirizine hydrochloride tablet and a preparation method thereof. The cetirizine hydrochloride tablet is prepared by using the following method: dissolving cetirizine hydrochloride into a povidone aqueous solution; then, carrying out wet granulation on cetirizine hydrochloride and microcrystalline cellulose to obtain a cetirizine hydrochloride pretreated particle; and finally, uniformly mixing and tabletting the cetirizine hydrochloride pretreated particle and pharmaceutically available auxiliary materials, wherein the weight ratio of cetirizine hydrochloride to the microcrystalline cellulose is 1:1 to 1:15.

The invention discloses a cetirizine hydrochloride tablet and a preparation method thereof. The method comprises the following steps: dissolving cetirizine hydrochloride into water, and adding an alkaline matter to form cetirizine alkali so that the solubility is reduced and the cetirizine alkali is separated out; filtering, drying and crushing the cetirizine alkali, so as to obtain cetirizine powder; dissolving the cetirizine alkali and deoxycholic acid into ethyl alcohol, and carrying out rotary evaporation to remove ethyl alcohol, so as to obtain cetirizine deoxycholic acid dispersion powder; and evenly mixing the cetirizine deoxycholic acid dispersion powder with pharmaceutically available auxiliary materials and tabletting, so as to obtain the rapidly dissolved cetirizine tablet.