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Cetirizine hydrochloride syrup

A technology of cetirizine hydrochloride and syrup, which is applied in the field of medicine, can solve the problems of not being able to provide cetirizine hydrochloride, etc., and achieve the effects of good taste, simple preparation process and good stability of the preparation

Active Publication Date: 2015-01-28
LUNAN BETTER PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0018] Searched the existing patented technology and found that the existing technology failed to provide a syrup of cetirizine hydrochloride with good taste and stable properties

Method used

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  • Cetirizine hydrochloride syrup
  • Cetirizine hydrochloride syrup
  • Cetirizine hydrochloride syrup

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] prescription:

[0036]

[0037] Preparation Process:

[0038] Dissolve xanthan gum with part of disodium hydrogen phosphate-citrate buffer solution (pH4.0), add cetirizine hydrochloride, sucrose, aspartame, sodium glutamate and stir to dissolve, add disodium hydrogen phosphate - dilute to full volume with citric acid buffer solution (pH4.0), filter through a microporous membrane, pack and sterilize, ready to use.

Embodiment 2

[0040] prescription:

[0041]

[0042] Preparation Process:

[0043] Dissolve xanthan gum with part of disodium hydrogen phosphate-citrate buffer solution (pH4.0), add cetirizine hydrochloride, sucrose, aspartame, sodium glutamate and stir to dissolve, add disodium hydrogen phosphate - dilute to full volume with citric acid buffer solution (pH4.0), filter through a microporous membrane, pack and sterilize, ready to use.

Embodiment 3

[0045] prescription:

[0046]

[0047] Preparation Process:

[0048] Dissolve xanthan gum with part of disodium hydrogen phosphate-citrate buffer solution (pH4.0), add cetirizine hydrochloride, sucrose, aspartame, sodium glutamate and stir to dissolve, add disodium hydrogen phosphate - dilute to full volume with citric acid buffer solution (pH4.0), filter through a microporous membrane, pack and sterilize, ready to use.

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Abstract

The invention provides cetirizine hydrochloride syrup. The syrup comprises cetirizine hydrochloride, sodium glutamate, xanthan gum, saccharose, a pH regulator, a flavoring agent and water, wherein the weight ratio of cetirizine hydrochloride to xanthan gum is 1:(1-10), preferably 1:5; the using amount of sodium glutamate accounts for 0.5-1.0 percent of the total weight of the syrup; the pH regulator is a disodium hydrogen phosphate-citric acid buffer solution; and the flavoring agent is aspartame, steviosin or sodium saccharin. The cetirizine hydrochloride syrup has excellent taste, stable property and simple preparation process.

Description

technical field [0001] The invention belongs to the technical field of medicines, in particular to a cetirizine hydrochloride syrup. Background technique [0002] Cetirizine Hydrochloride (Cetirizine Hydrochloride) is a second-generation antihistamine, the chemical name is (±)-2-[2-[4-[(4-chlorophenyl)benzyl]-1-piperazine Base] ethoxy] acetic acid dihydrochloride, molecular formula: C 21 h 25 ClN 2 o 3 2HCl, molecular weight: 461.82, structural formula as follows: [0003] [0004] Cetirizine hydrochloride is a potent H1 receptor antagonist. It is orally administered into the body and quickly binds to the histamine H1 receptor on the target cell membrane, blocking the activation of target cells by histamine. Cetirizine has no obvious anticholinergic and anti-serotonin effects. In normal doses, it is difficult to pass through the blood-brain barrier. This product can inhibit the transmission of histamine in the early stage of allergic reaction, reduce the migratory ...

Claims

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Application Information

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IPC IPC(8): A61K9/10A61K31/495A61K47/12A61K47/04A61K47/36A61K47/18A61P37/08
Inventor 赵志全陈小伟郑华范锋
Owner LUNAN BETTER PHARMA
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