Cetirizine hydrochloride tablet

The technology of cetirizine hydrochloride and cetirizine is applied in the directions of pill delivery, organic active ingredients, medical preparations containing active ingredients, etc., and can solve the problems of increased tablet weight, complicated preparation process, inconvenient medication for patients, and the like, Achieve the effect of no corrosion and rapid dissolution

Active Publication Date: 2015-04-29
LUNAN BETTER PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the preparation process is complicated. Although the contact between the drug and the equipment is avoided and the corrosion of the equipment is prevented, the weight of the tablet is increased, which brings inconvenience to the patient.

Method used

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  • Cetirizine hydrochloride tablet
  • Cetirizine hydrochloride tablet
  • Cetirizine hydrochloride tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018]

[0019] Preparation Process:

[0020] Cetirizine hydrochloride is dissolved in 0.1mol / L sodium hydroxide solution aqueous solution, forms cetirizine base, causes its solubility to drop and precipitates out, filters, dries, pulverizes, obtains the powder of cetirizine; Cetirizine Alkali and deoxycholic acid were dissolved in ethanol, and the ethanol was removed by rotary evaporation to obtain cetirizine deoxycholic acid dispersion powder, and then mixed with the prescribed amount of microcrystalline cellulose, lactose, sodium carboxymethyl starch, cross-linked carboxy Sodium methylcellulose and magnesium stearate were uniformly mixed and compressed into tablets to obtain a rapidly dissolving cetirizine tablet.

Embodiment 2

[0022]

[0023] Preparation Process:

[0024] Cetirizine hydrochloride is dissolved in 0.1mol / L potassium hydroxide solution aqueous solution to form cetirizine base, causing its solubility to drop and precipitate out, filter, dry and pulverize to obtain the powder of cetirizine; cetirizine Alkali and deoxycholic acid are dissolved in ethanol, and the ethanol is removed by rotary evaporation to obtain cetirizine deoxycholic acid dispersion powder, and then mixed with the prescribed amount of microcrystalline cellulose, sodium carboxymethyl starch, magnesium stearate, The talcum powder was mixed uniformly and tableted to obtain a rapidly dissolving cetirizine tablet.

Embodiment 3

[0026]

[0027] Preparation Process:

[0028] Cetirizine hydrochloride is dissolved in 0.1mol / L sodium hydroxide solution aqueous solution, forms cetirizine base, causes its solubility to drop and precipitates out, filters, dries, pulverizes, obtains the powder of cetirizine; Cetirizine Alkali and deoxycholic acid are dissolved in ethanol, and the ethanol is removed by rotary evaporation to obtain cetirizine deoxycholic acid dispersion powder, which is then mixed with the prescribed amount of microcrystalline cellulose, crospovidone, and magnesium stearate Uniform, tabletting, obtained the cetirizine tablet that dissolves rapidly.

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PUM

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Abstract

The invention discloses a cetirizine hydrochloride tablet and a preparation method thereof. The method comprises the following steps: dissolving cetirizine hydrochloride into water, and adding an alkaline matter to form cetirizine alkali so that the solubility is reduced and the cetirizine alkali is separated out; filtering, drying and crushing the cetirizine alkali, so as to obtain cetirizine powder; dissolving the cetirizine alkali and deoxycholic acid into ethyl alcohol, and carrying out rotary evaporation to remove ethyl alcohol, so as to obtain cetirizine deoxycholic acid dispersion powder; and evenly mixing the cetirizine deoxycholic acid dispersion powder with pharmaceutically available auxiliary materials and tabletting, so as to obtain the rapidly dissolved cetirizine tablet.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical solid oral preparations, in particular to a cetirizine hydrochloride tablet. Background technique [0002] Cetirizine hydrochloride is a selective histamine H1 receptor antagonist. As a new type of antihistamine, it is mainly used to relieve allergic symptoms of allergic diseases. It is clinically used for the treatment of allergic rhinitis, urticaria, vascular nerve It has many advantages such as rapid oral absorption, high receptor selectivity, strong clinical curative effect, small side effects, and good safety. It is the first choice drug for the treatment of allergic diseases. [0003] At present, there are many dosage forms of cetirizine hydrochloride, but mainly in tablets. However, cetirizine hydrochloride is highly acidic and often corrodes preparation equipment such as tablet press turntables, punches, dies, granulators, fluidized beds, especially in production environments with ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/495A61P37/08
Inventor 张贵民任英何艳琴
Owner LUNAN BETTER PHARMA
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