39 results about "Allergic symptoms" patented technology

The invention relates to the technical field of allergy detection, in particular to an inhalation allergen specific IgE antibody detection kit and application thereof. The kit is a colloidal gold detection kit. The detection objects are pollen, dust mites and animal scurf; the kit comprises a colloidal gold labeled mouse anti-human IgE antibody arranged on a test strip combination pad; the pollen antigens (Art v1, Amb a1 and Bet v2), the dust mite antigens (Der f1 and Der p1) and the animal scurf antigen (Can f1) are arranged on a nitrocellulose membrane of the test strip. The kit provided by the invention can be used for rapidly identifying the allergen of the inhalation allergy symptom and classifying the severity of the allergy symptom, and the identification result has relatively high accuracy.

The invention discloses a preparation method of phospholipid type DHA (docosahexaenoic acid) and application of the phospholipid type DHA in preparation of products for improving allergy symptoms, and belongs to the technical field of preparation and application of the phospholipid type DHA. Obtaining free DHA from the fish oil; soybean lecithin and free DHA are mixed, n-hexane is added for ultrasonic dissolution, enzyme is added after dissolution, nitrogen is filled for sealing for reaction, enzyme is removed after the reaction is finished, an organic solvent is removed from reaction liquid through rotary evaporation, mixed grease is obtained, and the phospholipid type DHA is obtained through purification. In the aspect of improving allergy, the phospholipid DHA prepared by the invention has a better mixing effect than fish oil and soybean lecithin, and has a good application prospect in the aspect of preparing functional foods, medicines or medicine carriers.

The invention relates to the technical field of microorganisms, in particular to a yeast metagen with an anti-allergic effect as well as a preparation method and application of the yeast metagen. According to the invention, the metabolite is an inactivated saccharomyces boulardii strain and a fermentation metabolite thereof, wherein the preservation number of the saccharomyces boulardii strain is CCTCC (China Center for Type Culture Collection) NO: M 20251803. The metagen can be used for remarkably reducing the total IgE (Immunoglobulin E) level of serum and relieving anaphylactic reaction by adjusting the balance of Th1 / Th2, Th17 and Treg immune cells. Therefore, the metabiotics disclosed by the invention have a wide application prospect in preparation of foods, medicines or health-care products for relieving allergic symptoms.

The system according to the embodiment comprises a receiving unit, a proposal unit, an acquisition unit, an accumulation unit, and an identification unit. The receiving unit receives allergy information, food preferences, or information on an amount of exercise of a user. The proposal unit analyzes the information received by the receiving unit and proposes a recipe. The acquisition unit acquires special sale information of a nearby supermarket. The accumulation unit accumulates ingredient list images of consumed food. The identification unit identifies which ingredient is suspected when an allergic symptom occurs.

The object of the present invention is to provide an inflammation inhibitor that can reduce oxidative damage and allergic symptoms of the scalp by using a substance that does not interfere with the progress of oxidation reactions during hair dyeing and that preferentially removes more damaging peroxides. [Solution] This is an inflammation inhibitor that reduces inflammatory damage to the scalp and allergic inflammatory reactions that occur when dyeing hair with an oxidative hair dye, and contains an antioxidant that removes peroxides produced by the reaction between the oxidative dye contained in the hair dye and hydrogen peroxide without inhibiting the oxidation reaction during hair dyeing.

The invention discloses a treatment composition to treat nasal or oral dryness and allergy symptoms, and a method for using the same. Certain compositions include xylitol, at least two wetting agents, an aqueous carrier, and other active ingredients, such as a potassium salt, a sodium salt, and a preservative. The composition may be configured as a nasal or oral spray, and oral rinse, or a nasal gel.

The invention provides a pollen vaccine based on an aluminum-CpG composite adjuvant and application of the pollen vaccine. The pollen vaccine comprises an aluminum-CpG chemical coupling nano adjuvant and a recombinant mugwort main allergen, the adjuvant is a substance formed by coupling an aluminum oxygen hydride nanorod and CpG through an amido bond, carboxyl on the surface of an AlOOH nanorod is activated, and then the AlOOH nanorod reacts with aminated CpG ODN to obtain the adjuvant. Stable combination of the aluminum salt nanoparticles and CpG ODN is achieved through chemical coupling, the coupling efficiency is larger than or equal to 95%, cytotoxicity is avoided, the problems that in traditional physical mixing, the aluminum salt nanoparticles and CpG ODN are not synergistic in effect and prone to dissociation are solved, and the synergistic immunoregulation effect of adjuvant components is ensured; after the adjuvant is loaded with the Artemisia pollen allergen Art v1, the IgE level can be remarkably reduced, lung inflammation can be relieved, allergic symptoms can be improved in treatment and prevention models, and a novel adjuvant platform is provided for immunotherapy of pollen allergy.

The application relates to the technical field of allergy detection, in particular to an inhaled allergen specific IgE antibody detection kit and application thereof. The kit is a colloidal gold detection kit; the detection object is pollen, dust mites and animal dander; the kit comprises colloidal gold labeled mouse anti-human lgE antibodies arranged on a test strip combination pad; and pollen antigens (Art v1, Amb a1, Bet v2), dust mite antigens (Der f1, Der p1) and animal dander antigens (Can f1) arranged on a test strip nitrocellulose membrane. The kit provided by the application can quickly identify the allergen of inhaled allergic symptoms, classify the severity of allergic symptoms, and the identification result has a high accuracy.

The application discloses a sesquiterpene derivative, a preparation method and application thereof. The application provides a novel sesquiterpene derivative which is obtained by modifying atractylodin III. Activity research shows that the sesquiterpene derivative has stronger inhibiting effect on IgE or histamine secretion than atractylodin III. It is known to those skilled in the art that allergy is mediated by IgE, and histamine secretion under the stimulation of IgE is an important cause of various allergic symptoms. Therefore, the sesquiterpene derivative provided by the application has the prospect of being developed into a medicine for preventing and / or treating diseases which are prevented and / or treated by inhibiting IgE or histamine secretion, such as allergic diseases like food allergy.

The invention provides a nasal cavity nursing allergy symptom monitoring system and method. The method comprises the following steps: extracting characteristic impedance parameters reflecting the connection tightness degree between mucous membrane epithelial cells according to electrical impedance spectrum data of a user nasal cavity mucous membrane surface; determining the offset of the characteristic impedance parameter relative to the reference value of the personal health state of the user, and further generating a quantitative attenuation coefficient of the nasal mucosa defense function; according to real-time allergen concentration data of the environment where the user is located and in combination with preset individual standard breathing parameters, the allergen inhalation dosage of the user in unit time is determined, and then the individual exposure level of the user is determined according to the quantitative attenuation coefficient and the allergen inhalation dosage of the user in unit time; and performing risk assessment based on the individual exposure level and the allergen specificity IgE detection result of the user, and further generating the risk level of allergy attack of the user in the environment where the user is located. By adopting the scheme of the invention, evaluation distortion caused by individual real-time defense function difference can be reduced.

The application discloses application of a Corydalis yanhusuo extract in preparation of an anti-allergic drug and belongs to the technical field of anti-allergic drug preparation. The treatment effect of the drug on allergic diseases is evaluated by comparing P815 cell degranulation and inflammatory factor release, the inflammatory infiltration degree of a local skin allergic reaction of a mouse, and the allergic symptoms of a mouse as a whole, so that it is determined that the Corydalis yanhusuo extract can be used for preparation of an anti-allergic drug. The Corydalis yanhusuo extract can effectively alleviate the local and systemic allergic reaction symptoms of a mouse, and reduce mast cell degranulation, and has a significant improvement effect on symptoms caused by allergic reactions.

The invention discloses bifidobacterium bifidum capable of relieving postpartum constipation of a mother generation and food allergy of a child generation and application of the bifidobacterium bifidum, and belongs to the field of microorganisms. A strain of bifidobacterium bifidum CCFM1523 is screened out, postpartum constipation of female rats is relieved, specifically, the number and weight of black excrement grains in 5 h and the small intestine propulsion rate can be increased, and the first black excrement discharging time is shortened. When young rats take the probiotics bifidobacterium bifidum CCFM1523, the allergic symptom is relieved to a certain degree, and particularly, the apparent score of food allergic rats induced by OVA and the content of OVA-sIgE and mMCP-1 in bodies are reduced. The bifidobacterium bifidum CCFM1523 has the effect of relieving intractable constipation in a purgative colonic animal model constructed by using the folium sennae, specifically, after intervention of the bifidobacterium bifidum CCFM1523, the number of excrement grains of mice within 5 hours and the water content of the excrement are remarkably increased, and meanwhile, the time for discharging first black excrement is shortened.

The invention discloses polygalacturonic acid (PGA) and application of a neohesperidin dihydrochalcone (NHDC) or neohesperidin (NH) embedded compound of the polygalacturonic acid (PGA) in preparation of anti-allergic food or drugs. The PGA has good biocompatibility and immune regulation and intestinal barrier repair functions. Experiments show that the PGA can significantly reduce IgE-mediated food anaphylaxis, alleviate allergic symptoms and improve intestinal structures. PGA is adopted as a carrier, and the PGA and NHDC / NH form non-covalent binding through intermolecular force to prepare the PGA-NHDC / PGA-NH compound, so that the solubility and the stability of the NHDC / NH are improved, and a synergistic anti-allergic effect is also generated. The PGA-NHDC / PGA-NH compound has the advantages of small molecular weight, fast absorption and non-immunogenicity, and can release NHDC / NH in colon in a targeted manner. On the basis, the invention further provides the application of the PGA-NHDC / PGA-NH compound in preparation of the orange juice, the obtained juice system is in a stable suspension state, has no precipitation layering phenomenon, has targeted synergistic antianaphylaxis and high storage stability, and remarkably improves the functionality and the storage stability of the juice.

The application discloses a soothing and anti-allergic composition and a preparation method and application thereof. The soothing and anti-allergic composition comprises the following components in parts by weight: sea salt 0.001-5.0 parts; hydrolyzed seaweed extract 0.001-3.0 parts; Illicium micranthum leaf extract 0.001-5.0 parts; and polysaccharide 0.001-1.0 part. The soothing and anti-allergic composition is composed of sea salt containing rich mineral elements, hydrolyzed seaweed extract capable of promoting blood circulation, Illicium micranthum leaf extract capable of inhibiting TRPV1 expression and polysaccharide capable of improving skin activity. The sea salt, the polysaccharide, the Illicium micranthum leaf extract and the hydrolyzed seaweed extract have a synergistic effect, and can achieve unexpected effects of instant soothing and continuous alleviation of allergic symptoms.

The invention provides a low-allergy and anti-allergy plaster based on allantoin and a preparation method thereof. Relates to the field of skin medical supplies. The coconut oil acyl hydrolyzed collagen potassium of the plaster formed by the scheme can promote the proliferation of primary fibroblasts, so that the regeneration of the skin is accelerated from the primary fibroblasts, and the regeneration of the skin at the position covered by the plaster can be accelerated, thereby avoiding various reactions caused by the allergy of the position covered by the plaster. Besides, allantoin has good soothing, anti-inflammatory and repairing effects, can relieve the allergic state of the skin, and can effectively reduce the allergic feeling of a user; asiaticoside, trehalose and medical silicone can accelerate cell repair and effectively relieve allergic symptoms of a user. The optimal use proportion of the materials is obtained through experiments, the synergistic effect of the materials is the strongest under the proportion, the serious allergy phenomenon of a user can be weakened into the slight allergy phenomenon, and the moderate allergy phenomenon and the slight allergy phenomenon are eliminated intangibly.

The invention relates to the field of application of food functional factors, and particularly discloses a method for relieving cow milk allergy by using chitosan oligosaccharide and application. According to the method, chitosan oligosaccharide is given before sensitization, during sensitization or after sensitization; the chitosan oligosaccharide can be used for remarkably reducing the levels of serum IgE (Immunoglobulin E), IgG1 (Immunoglobulin G1), IL-4 (Interleukin-4), IL-10 (Interleukin-10), IL-17A (Interleukin-10), histamine and mast cell proteinase-1, and increasing the expression of IFN (Interferon)-gamma to regulate the immune balance of Th1 / Th2 / Th17; the alpha diversity and beta diversity of intestinal flora are improved, and the stable state of the flora is recovered; the allergy symptoms are relieved; the intestinal tract tissue injury is repaired. The chitosan oligosaccharide can be used for preparing functional foods or compositions for resisting cow milk allergy, and has application prospects in infant formula foods, solid beverages and dairy products.

Pro-toothpaste compositions formulated to receive a volume of allergen solution to provide toothpastes that exhibit efficacy for oral mucosal immunotherapy (OMIT) and acceptable consumer and product stability properties, along with kits of pro-toothpaste, allergen / extracts of allergens, and optionally compounding means and / or specialized toothbrushes are provided. Toothpastes suitable and effective for OMIT and methods for managing allergic symptoms and for reducing risk of allergy in people without symptoms employing the pro-toothpastes, toothpastes, and kits of the invention are also disclosed.

The invention discloses application of bifidobacterium animalis in relieving respiratory tract allergy symptoms, and belongs to the technical field of microorganisms. The technical problem to be solved is to provide the application of the bifidobacterium animalis in relieving the respiratory tract allergy symptoms, the key point of the technical scheme is the application of the bifidobacterium animalis subsp. Lactis BL-5M in relieving the respiratory tract allergy symptoms, and the preservation number of the bifidobacterium animalis subsp. Lactis BL-5M is CGMCC (China General Microbiological Culture Collection Center) No.33449. The medicine can act on the core mechanism of respiratory tract allergy, and the sneezing / cough frequency caused by respiratory tract stimulation reflex is reduced; the lung tissue enlargement mediated by allergic inflammation is relieved; the ratio of eosinophilic granulocytes in bronchoalveolus is reduced; the concentration of proinflammatory factors IL-4 and IL-5 in bronchoalveolus alveolus is reduced; inflammatory cell infiltration around the lung airway wall is reduced; the IgE content in a body circulation system or local tissues is reduced, meanwhile, the diversity of intestinal flora is improved, anti-inflammatory functional flora is accurately enriched, and the allergic asthma is improved in a targeted manner.

The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a traditional Chinese medicine composition for treating allergic rhinitis and a preparation method of the traditional Chinese medicine composition. 5 to 20 parts of astragalus polysaccharide; 2 to 8 parts of glycyrrhizin; 1 to 5 parts of ceramide; 3-10 parts of a radix angelicae dahuricae extract; 3-10 parts of a cocklebur fruit extract; 5 to 15 parts of baicalin; and 1-5 parts of magnolia flower volatile oil. Wherein the active component of the supercritical extract of the coptis chinensis paste can correct proportional imbalance of immune cells from a transcriptional level, and can also cooperate with baicalin to inhibit phosphorylation and nuclear translocation of related signal pathways, inhibit effector cell activation degranulation and reduce expression and secretion of proinflammatory factors; the fructus xanthii extract and the flos magnoliae volatile oil can quickly relieve acute allergy symptoms, and the plant ceramide repairs the physical barrier of nasal mucosa in a targeted manner, so that the problems that in the prior art, a modern conversion process of a classic prescription is difficult in quality control, the preparation lacks local targeting, and the research on a compound mechanism is shallow are solved.

The utility model discloses a kind of heating ventilation air conditioner with circulating humidification mechanism, including air conditioner body, supporting cylindrical pedestal, fixed cylinder, cylindrical gear, heating box, conveying pipeline, moisture outlet mechanism and top humidification mechanism, and the top humidification mechanism is fixedly connected in the top of air conditioner body;The utility model, by cylinder work, promote moisture outlet mechanism motion to the outside of top humidification mechanism, heating box is heated into water vapor with the water inside, is conveyed to moisture outlet mechanism by conveying pipeline, connecting pipe and sliding shaft, and then is conveyed into room, adjust the humidity in air, help to alleviate allergic symptoms and promote overall air quality, reduce static phenomenon, be conducive to the protection of electronic equipment;The output end of motor rotates and drives rotating shaft to rotate, and then drives cylindrical gear to rotate, finally drives fixed cylinder to rotate, drives air conditioner body to rotate, can rotate heating ventilation air conditioner according to actual needs, need not hard work to carry.

This invention belongs to the field of biomedical technology, specifically relating to a pharmaceutical composition for treating allergic conjunctivitis in children, its preparation method, and its uses. The pharmaceutical composition of this invention comprises hsa-miR-19b mimic and an immune peptide, wherein the immune peptide is a fusion peptide NGF-FGF, a combination of nerve growth factor (NGF) and fibroblast growth factor (FGF). In vitro and in vivo experiments have confirmed that hsa-miR-19b mimic and the fusion peptide NGF-FGF can alleviate the course of allergic conjunctivitis in children and reduce allergic symptoms by inhibiting the expression of inflammatory factors and reducing inflammatory responses.

The invention discloses a sesquiterpene derivative as well as a preparation method and application thereof. The invention provides a sesquiterpene derivative with a novel structure. The sesquiterpene derivative is obtained by modifying atractylenolide III. An activity research shows that the sesquiterpene derivative has a stronger effect of inhibiting IgE (Immunoglobulin E) or histamine secretion than atractylenolide III. Technicians in the field know that allergy is mediated by IgE, and histamine secretion under IgE stimulation is an important reason for causing various allergy symptoms. Therefore, the sesquiterpene derivative provided by the invention has the prospect of being developed into drugs for preventing and treating diseases, such as food allergy and other allergic diseases, which are prevented and / or treated by inhibiting IgE or histamine secretion.

The present application provides a new use of ganciclovir for treating, alleviating and / or relieving non-allergic rhinitis characterized by eosinophilia. The present application research shows that the use of ganciclovir in the treatment of nasal allergic symptoms in NARES patients is obviously relieved, and the originally poor efficacy of anti-allergic drugs can be re-exerted, effectively and durably improving the nasal symptoms of refractory NARES patients, effectively improving the symptoms of rhinitis.

The invention belongs to the technical field of probiotic fermentation, and particularly relates to application of lactobacillus rhamnosus and medicinal and edible leavening preparation in the aspects of body immune regulation, immune balance maintenance and allergic symptom and inflammatory response relieving. Lactic acid bacteria with anti-allergic activity and good fermentation performance are screened to serve as fermentation strains, fructo-oligosaccharide, lilies and poria cocos with immunoregulatory activity are fermented, and further, the produced fermentation product with the anti-allergic activity is compounded with bifidobacteria to form the function-enhanced anti-allergic composition. Results of embodiments show that the prepared medicinal and edible leavening not only can effectively improve allergy caused by Thl / Th2 imbalance, but also can effectively regulate the intestinal flora structure and maintain immune balance.

The multi-modal biofeedback allergy defense massage control method comprises the following steps: acquiring multi-modal data of a user in a massage process in real time, determining whether the user has an allergy symptom before massage, and when the user has the allergy symptom before massage, outputting the acquired multi-modal data at a first moment as first multi-modal data; when the user does not have allergy symptoms before massage, constructing an antagonistic allergy risk model based on sympathetic / parasympathetic nerve activity indexes; performing real-time risk assessment by the antagonistic allergy risk model based on the multi-modal data acquired in real time, and outputting the multi-modal data as second multi-modal data when the risk assessment result is that the user has an allergy symptom; constructing a massage control model, and adjusting massage parameters of the massage equipment based on the first multi-modal data or the second multi-modal data by adopting the massage control model; according to the invention, the massage parameters of the user who is allergic or allergic in the massage process can be adjusted, so that the allergy symptom is relieved.

Methods of treating an allergic symptom by oral administration of epinephrine and its prodrugs are described as having pharmacokinetic parameters that are improved or comparable to those compositions administered by intramuscular injection.

The invention discloses lactobacillus reuteri and application thereof. The lactobacillus reuteri C3 has the preservation number of CCTCC (China Center For Type Culture Collection) NO: M 20252241. The traditional Chinese medicine composition has the effects of regulating intestinal flora, enhancing immunity, relieving diarrhea, improving allergic symptoms, inhibiting helicobacter pylori and the like. The hermetia illucens larva pulp feed fermented by the lactobacillus reuteri has the advantages of high protein and low antinutritional factors, and can replace soybean meal or fish meal to a certain extent to be used in preparation of livestock and poultry feed. According to the lactobacillus reuteri disclosed by the invention, high-nitrogen wastewater can be efficiently utilized, the wastewater is converted into high-value mycoprotein, and resource utilization of wastes is realized; the wastewater treatment cost is reduced and the circular economy development is promoted.

This invention belongs to the field of biomedical technology and provides a mussel adhesive protein and azelastine hydrochloride nasal thermosensitive gel, its preparation and application. The mussel adhesive protein and azelastine hydrochloride nasal thermosensitive gel includes an active ingredient and pharmaceutically acceptable excipients. The active ingredient is recombinant mussel adhesive protein mefp-5 subtype and azelastine hydrochloride. The excipients include a thermosensitive polymer, which is mixed with the active ingredient to form a thermosensitive gel system. This invention solves the technical problem that existing single-drug formulations cannot simultaneously provide rapid symptom relief and long-term mucosal barrier repair for allergic rhinitis by combining recombinant mussel adhesive protein mefp-5 subtype with mucosal repair function with azelastine hydrochloride, which has rapid anti-allergic effects. Pharmacodynamic studies have confirmed that the two active ingredients exhibit a significant synergistic effect (CDI < 0.7) in improving allergy symptoms, inhibiting inflammatory responses, and repairing the mucosal barrier.

The present invention discloses a method for preparing a solution for detecting allergen activity, an analytical method, and its application, relating to the field of immunoassay technology. A solution for detecting serum and nasal secretion IgE levels is prepared, and the correlation between seasonal pollen concentrations, serum IgE and nasal secretion IgE levels, and SAR allergy symptoms and CSMS is analyzed. The present invention also discloses the application of the method in preparing reagents, kits, test strips, or chips to assist in screening patients for seasonal allergic rhinitis treatment, providing support for new treatment strategies and drug development.