62 results about "Allergic symptoms" patented technology

The invention discloses bifidobacterium longum subsp.infantis capable of relieving and preventing allergic rhinitis and application of the bifidobacterium longum subsp.infantis, and belongs to the technical field of microorganisms and the technical field of medicines. The bifidobacterium longum subsp. Infantis CCFM111 can relieve allergic reaction of allergic mice and relieve and prevent allergic diseases of perennial allergic rhinitis patients, and is specifically shown as follows: (1) weight loss and symptoms caused by allergy of the mice are relieved; lung inflammation infiltration is reduced; the OVA-sIgE level and the total IgE level of serum are reduced; the expression of a proinflammatory factor and an anti-inflammatory factor is regulated. (2) allergy symptoms and medication scores of patients are reduced; the asymptomatic day number proportion of the patient is increased; the serum dermatophagoides farinae and dermatophagoides farinae-sIgE level of patients is reduced; and the expression of cytokines in serum of a patient and nasal irrigation solution is regulated. Therefore, the bifidobacterium longum subsp. Infantis CCFM111 has a huge application prospect in preparation of products for preventing and / or treating allergic rhinitis.

To provide a system that includes: means that proposes recipes that take into consideration allergies, food preferences, and activity levels of a child, gets information about special offers at nearby supermarkets, and proposes recipes that use affordable and seasonal ingredients; and means that accumulates images of food ingredient lists, when allergic symptoms appear, AI will suggest which ingredients are suspected.SOLUTION: The system includes: means for proposing recipes that take into account allergies, food preferences, and physical activity levels of a child; means of getting information about special offers at nearby supermarkets, and means of proposing recipes that use affordable and seasonal ingredients; and means that accumulates images of the ingredients of foods consumed, and when allergic symptoms appear, AI suggests which ingredients are suspected.SELECTED DRAWING: Figure 1

The invention relates to the technical field of rhinitis medicine preparation, in particular to zirconium-doped cerium oxide nano-enzyme for preparing allergic rhinitis drops and a preparation method of the zirconium-doped cerium oxide nano-enzyme. The preparation method comprises the following steps: step 1, weighing a cerium acetylacetonate (III) hydrate and a zirconium acetylacetonate (IV) hydrate, adding into oleylamine, magnetically stirring and uniformly mixing, and carrying out ultrasonic treatment on the mixture; step 2, putting the mixed solution in the step 1 into a drying oven, heating, preserving heat, and aging to obtain a dark brown colloidal solution; step 3, naturally cooling the colloidal solution to room temperature, adding acetone, centrifuging, discarding supernate, and repeating centrifugal washing for several times; and 4, carrying out vacuum drying on the precipitate obtained in the step 3, and fully grinding to obtain the zirconium-doped cerium oxide nano-enzyme. The prepared zirconium-doped cerium oxide nano-enzyme is applied to preparation of allergic rhinitis drops. The zirconium-doped cerium oxide nano enzyme reduces the inflammatory factor level of the AR mouse and inhibits degranulation of nasal mucosa MCs, so that the pathological state and allergic symptoms of the AR mouse are improved.

The invention discloses bifidobacterium bifidum and application of the bifidobacterium bifidum in relieving ovalbumin-induced food allergy, and belongs to the technical field of microorganisms. According to the invention, a strain of bifidobacterium bifidum CCFM1063 is screened out, and the bifidobacterium bifidum CCFM1063 has the effects of relieving weight loss and allergic symptoms of mice caused by OVA; according to the present invention, with the application of the loratadine, the high mMCP-1 level caused by OVA can be significantly reduced, the IgE level can be reduced, the mRNA level of the jejunum allergy related cytokines such as TSLP, IL-4 and IL-33 can be significantly reduced, and the partial effect is superior to the loratadine; when the bifidobacterium bifidum CCFM1063 is combined with breast milk oligosaccharide 3 '-SL, the bifidobacterium bifidum CCFM1063 has a synergistic effect on improving food allergy symptoms, and the effect of the bifidobacterium bifidum CCFM1063 is obviously superior to that of a single strain.

The invention relates to the technical field of allergy detection, in particular to an inhalation allergen specific IgE antibody detection kit and application thereof. The kit is a colloidal gold detection kit. The detection objects are pollen, dust mites and animal scurf; the kit comprises a colloidal gold labeled mouse anti-human IgE antibody arranged on a test strip combination pad; the pollen antigens (Art v1, Amb a1 and Bet v2), the dust mite antigens (Der f1 and Der p1) and the animal scurf antigen (Can f1) are arranged on a nitrocellulose membrane of the test strip. The kit provided by the invention can be used for rapidly identifying the allergen of the inhalation allergy symptom and classifying the severity of the allergy symptom, and the identification result has relatively high accuracy.

The invention discloses a preparation method of phospholipid type DHA (docosahexaenoic acid) and application of the phospholipid type DHA in preparation of products for improving allergy symptoms, and belongs to the technical field of preparation and application of the phospholipid type DHA. Obtaining free DHA from the fish oil; soybean lecithin and free DHA are mixed, n-hexane is added for ultrasonic dissolution, enzyme is added after dissolution, nitrogen is filled for sealing for reaction, enzyme is removed after the reaction is finished, an organic solvent is removed from reaction liquid through rotary evaporation, mixed grease is obtained, and the phospholipid type DHA is obtained through purification. In the aspect of improving allergy, the phospholipid DHA prepared by the invention has a better mixing effect than fish oil and soybean lecithin, and has a good application prospect in the aspect of preparing functional foods, medicines or medicine carriers.

The invention discloses a substance with anti-allergic activity and application thereof, the substance with anti-allergic activity is a bitter receptor stimulant, and the bitter receptor stimulant is selected from at least one of denatonium benzoate, difenidol and quinine. The compound can reduce the expression level of IgE in serum, inhibit mast cell degranulation and regulate and control expression of cytokines at the downstream of Th1, Th2 and Dc cells, so that allergy is prevented and allergic symptoms are relieved, and the compound can be used for preparing medicines, health foods, functional foods and dietary supplements for preventing and relieving food allergy.

The invention relates to the technical field of microorganisms, in particular to a yeast metagen with an anti-allergic effect as well as a preparation method and application of the yeast metagen. According to the invention, the metabolite is an inactivated saccharomyces boulardii strain and a fermentation metabolite thereof, wherein the preservation number of the saccharomyces boulardii strain is CCTCC (China Center for Type Culture Collection) NO: M 20251803. The metagen can be used for remarkably reducing the total IgE (Immunoglobulin E) level of serum and relieving anaphylactic reaction by adjusting the balance of Th1 / Th2, Th17 and Treg immune cells. Therefore, the metabiotics disclosed by the invention have a wide application prospect in preparation of foods, medicines or health-care products for relieving allergic symptoms.

The system according to the embodiment comprises a receiving unit, a proposal unit, an acquisition unit, an accumulation unit, and an identification unit. The receiving unit receives allergy information, food preferences, or information on an amount of exercise of a user. The proposal unit analyzes the information received by the receiving unit and proposes a recipe. The acquisition unit acquires special sale information of a nearby supermarket. The accumulation unit accumulates ingredient list images of consumed food. The identification unit identifies which ingredient is suspected when an allergic symptom occurs.

The invention discloses a strain with anti-allergy and immunity improving effects and application of the strain. The strain is Lactobacillus acidophilus L59, is preserved in Guangdong Microbial Culture Collection Center, and has the preservation number of GDMCC NO.64842. The invention also discloses a preparation method of the strain. The preservation time is July 8, 2024; the strain with the anti-allergy and immunity-improving effects is obtained through screening, the strain has the anti-allergy and immunity-improving effects, IgE and histamine in serum of allergic mice can be reduced, then allergic symptoms can be relieved, and the strain takes effect quickly and is remarkable in effect.

The invention relates to the technical field of patient allergy monitoring, and discloses an anaphylactic reaction monitoring system based on a bracelet. According to the bracelet-based anaphylactic reaction monitoring system, real-time heart rate data, respiration times and real-time body temperature data of a patient injected with contrast drugs are collected in real time through the bracelet, corresponding mean values or frequencies and speedup are calculated according to the data, and calculated results are compared with corresponding threshold values one by one; since the heart rate, the breath and the body temperature of the patient can change obviously when the patient is allergic, when any three signals appear, the allergic symptom of the patient is judged, and the early warning sound is given out, so that the medical staff is reminded to treat the allergic symptom of the patient in time, and the patient is prevented from suffering from the allergic symptom. According to the method, medical staff do not need to manually observe whether the patient is allergic or not after injecting contrast drugs into the patient, and the medical staff can still find that the patient has allergic symptoms in time and make corresponding treatment in time when the patient is busy.

The object of the present invention is to provide an inflammation inhibitor that can reduce oxidative damage and allergic symptoms of the scalp by using a substance that does not interfere with the progress of oxidation reactions during hair dyeing and that preferentially removes more damaging peroxides. [Solution] This is an inflammation inhibitor that reduces inflammatory damage to the scalp and allergic inflammatory reactions that occur when dyeing hair with an oxidative hair dye, and contains an antioxidant that removes peroxides produced by the reaction between the oxidative dye contained in the hair dye and hydrogen peroxide without inhibiting the oxidation reaction during hair dyeing.

The present disclosure provides a method for preparing an antibacterial and flame-retardant mask, which relates to the field of masks. The method includes the following steps: (1) preparing a cotton spunlace non-woven fabric layer; (2) preparing a polypropylene melt-blown non-woven fabric protective layer; (3) preparing an antibacterial and flame-retardant layer; (4) a polypropylene melt-blown non-woven fabric protective layer; (5) stacking the fabrics in steps (1)-(4) from the inside to the outside in sequence, cutting to the required size; and inserting a nose clip above, performing embossing edge sealing on the outer side, and fixing and bonding the ear straps to the four corners of the mask body through hot melt adhesive and embossing; the antibacterial and flame-retardant layer is prepared by melt-blending a flame-retardant antibacterial nano modifier and polypropylene, spinning into a web, strengthening and finishing, and drying; the flame-retardant antibacterial nano modifier is an in-situ generated silver SiO2 / Al2O3 nanoporous hollow microsphere. The mask prepared by the present invention has good mechanical properties, good high-temperature resistance and flame-retardant effect, is not easy to cause allergic symptoms, has extremely high bactericidal effect and filtration effect, and has good inhalation and exhalation effects, and has broad application prospects.

The invention discloses a treatment composition to treat nasal or oral dryness and allergy symptoms, and a method for using the same. Certain compositions include xylitol, at least two wetting agents, an aqueous carrier, and other active ingredients, such as a potassium salt, a sodium salt, and a preservative. The composition may be configured as a nasal or oral spray, and oral rinse, or a nasal gel.

The invention provides a pollen vaccine based on an aluminum-CpG composite adjuvant and application of the pollen vaccine. The pollen vaccine comprises an aluminum-CpG chemical coupling nano adjuvant and a recombinant mugwort main allergen, the adjuvant is a substance formed by coupling an aluminum oxygen hydride nanorod and CpG through an amido bond, carboxyl on the surface of an AlOOH nanorod is activated, and then the AlOOH nanorod reacts with aminated CpG ODN to obtain the adjuvant. Stable combination of the aluminum salt nanoparticles and CpG ODN is achieved through chemical coupling, the coupling efficiency is larger than or equal to 95%, cytotoxicity is avoided, the problems that in traditional physical mixing, the aluminum salt nanoparticles and CpG ODN are not synergistic in effect and prone to dissociation are solved, and the synergistic immunoregulation effect of adjuvant components is ensured; after the adjuvant is loaded with the Artemisia pollen allergen Art v1, the IgE level can be remarkably reduced, lung inflammation can be relieved, allergic symptoms can be improved in treatment and prevention models, and a novel adjuvant platform is provided for immunotherapy of pollen allergy.

The application relates to the technical field of allergy detection, in particular to an inhaled allergen specific IgE antibody detection kit and application thereof. The kit is a colloidal gold detection kit; the detection object is pollen, dust mites and animal dander; the kit comprises colloidal gold labeled mouse anti-human lgE antibodies arranged on a test strip combination pad; and pollen antigens (Art v1, Amb a1, Bet v2), dust mite antigens (Der f1, Der p1) and animal dander antigens (Can f1) arranged on a test strip nitrocellulose membrane. The kit provided by the application can quickly identify the allergen of inhaled allergic symptoms, classify the severity of allergic symptoms, and the identification result has a high accuracy.

The application discloses a sesquiterpene derivative, a preparation method and application thereof. The application provides a novel sesquiterpene derivative which is obtained by modifying atractylodin III. Activity research shows that the sesquiterpene derivative has stronger inhibiting effect on IgE or histamine secretion than atractylodin III. It is known to those skilled in the art that allergy is mediated by IgE, and histamine secretion under the stimulation of IgE is an important cause of various allergic symptoms. Therefore, the sesquiterpene derivative provided by the application has the prospect of being developed into a medicine for preventing and / or treating diseases which are prevented and / or treated by inhibiting IgE or histamine secretion, such as allergic diseases like food allergy.

The invention provides a nasal cavity nursing allergy symptom monitoring system and method. The method comprises the following steps: extracting characteristic impedance parameters reflecting the connection tightness degree between mucous membrane epithelial cells according to electrical impedance spectrum data of a user nasal cavity mucous membrane surface; determining the offset of the characteristic impedance parameter relative to the reference value of the personal health state of the user, and further generating a quantitative attenuation coefficient of the nasal mucosa defense function; according to real-time allergen concentration data of the environment where the user is located and in combination with preset individual standard breathing parameters, the allergen inhalation dosage of the user in unit time is determined, and then the individual exposure level of the user is determined according to the quantitative attenuation coefficient and the allergen inhalation dosage of the user in unit time; and performing risk assessment based on the individual exposure level and the allergen specificity IgE detection result of the user, and further generating the risk level of allergy attack of the user in the environment where the user is located. By adopting the scheme of the invention, evaluation distortion caused by individual real-time defense function difference can be reduced.

The invention relates to the field of prevention and treatment of physical allergy of infants, in particular to a construction method of an animal model for allergy of infant nutrition rice flour food. The method includes: 1, adaptively feeding experimental animals in multiple groups randomly according to weights; 2, in the first day to the seventh day, different test adjuvants are used for experiments on each group of experimental animals, one group of experimental animals is subjected to negative blank control without adjuvants, and the other groups are divided into different small groups according to different test substances; the animals are fed regularly and quantitatively every day, a negative blank group is fed with a basic liquid feed agent without adjuvant matching, and the other groups are fed with liquid feed with the same amount containing 0.5 mL of immunologic adjuvant solution; 3, allergy excitation is conducted at 9: 00 a.m. on the eighth day, a blank group is fed with 5 g of purified water, the other groups are fed with 5 g of infant nutrition rice flour liquid feed, animal clinical allergic symptoms are observed, and blood and tissue samples are collected; killing the animal, and collecting a blood sample; the experimental animal is preferably an SPF (specific pathogen free) level female Wistar rat with the weight of 45-65 g and the age of 3 weeks.

The invention discloses a plant-based efficient skin anti-allergy soothing repair agent as well as a preparation method and application thereof. In the traditional Chinese medicine composition, various plant extracts such as the cortex dictamni extract, the fructus kochiae extract, the radix scutellariae extract, the dandelion extract and the honeysuckle flower extract have a synergistic effect, so that the traditional Chinese medicine composition has various effects of resisting allergy, bacteria, inflammation and viruses and the like. The components can effectively inhibit mast cell functions, reduce release of inflammatory mediators and relieve allergic symptoms, such as pruritus, redness and swelling, stabbing pain and the like. Meanwhile, soothing and repairing components in the formula, such as a chamomile extract, an aloe extract and a liquorice root extract, can effectively relieve symptoms such as skin itch, redness and swelling and the like, promote skin repair, help repair damaged skin barriers, enhance skin resistance and reduce allergy. The moisturizing components such as hyaluronic acid and ceramide can provide sufficient moisture and nutrition for the skin, keep the skin moist and smooth, lock the moisture in the skin and reduce moisture loss.

The application discloses application of a Corydalis yanhusuo extract in preparation of an anti-allergic drug and belongs to the technical field of anti-allergic drug preparation. The treatment effect of the drug on allergic diseases is evaluated by comparing P815 cell degranulation and inflammatory factor release, the inflammatory infiltration degree of a local skin allergic reaction of a mouse, and the allergic symptoms of a mouse as a whole, so that it is determined that the Corydalis yanhusuo extract can be used for preparation of an anti-allergic drug. The Corydalis yanhusuo extract can effectively alleviate the local and systemic allergic reaction symptoms of a mouse, and reduce mast cell degranulation, and has a significant improvement effect on symptoms caused by allergic reactions.

The invention discloses bifidobacterium bifidum capable of relieving postpartum constipation of a mother generation and food allergy of a child generation and application of the bifidobacterium bifidum, and belongs to the field of microorganisms. A strain of bifidobacterium bifidum CCFM1523 is screened out, postpartum constipation of female rats is relieved, specifically, the number and weight of black excrement grains in 5 h and the small intestine propulsion rate can be increased, and the first black excrement discharging time is shortened. When young rats take the probiotics bifidobacterium bifidum CCFM1523, the allergic symptom is relieved to a certain degree, and particularly, the apparent score of food allergic rats induced by OVA and the content of OVA-sIgE and mMCP-1 in bodies are reduced. The bifidobacterium bifidum CCFM1523 has the effect of relieving intractable constipation in a purgative colonic animal model constructed by using the folium sennae, specifically, after intervention of the bifidobacterium bifidum CCFM1523, the number of excrement grains of mice within 5 hours and the water content of the excrement are remarkably increased, and meanwhile, the time for discharging first black excrement is shortened.

The invention discloses polygalacturonic acid (PGA) and application of a neohesperidin dihydrochalcone (NHDC) or neohesperidin (NH) embedded compound of the polygalacturonic acid (PGA) in preparation of anti-allergic food or drugs. The PGA has good biocompatibility and immune regulation and intestinal barrier repair functions. Experiments show that the PGA can significantly reduce IgE-mediated food anaphylaxis, alleviate allergic symptoms and improve intestinal structures. PGA is adopted as a carrier, and the PGA and NHDC / NH form non-covalent binding through intermolecular force to prepare the PGA-NHDC / PGA-NH compound, so that the solubility and the stability of the NHDC / NH are improved, and a synergistic anti-allergic effect is also generated. The PGA-NHDC / PGA-NH compound has the advantages of small molecular weight, fast absorption and non-immunogenicity, and can release NHDC / NH in colon in a targeted manner. On the basis, the invention further provides the application of the PGA-NHDC / PGA-NH compound in preparation of the orange juice, the obtained juice system is in a stable suspension state, has no precipitation layering phenomenon, has targeted synergistic antianaphylaxis and high storage stability, and remarkably improves the functionality and the storage stability of the juice.

The application discloses a soothing and anti-allergic composition and a preparation method and application thereof. The soothing and anti-allergic composition comprises the following components in parts by weight: sea salt 0.001-5.0 parts; hydrolyzed seaweed extract 0.001-3.0 parts; Illicium micranthum leaf extract 0.001-5.0 parts; and polysaccharide 0.001-1.0 part. The soothing and anti-allergic composition is composed of sea salt containing rich mineral elements, hydrolyzed seaweed extract capable of promoting blood circulation, Illicium micranthum leaf extract capable of inhibiting TRPV1 expression and polysaccharide capable of improving skin activity. The sea salt, the polysaccharide, the Illicium micranthum leaf extract and the hydrolyzed seaweed extract have a synergistic effect, and can achieve unexpected effects of instant soothing and continuous alleviation of allergic symptoms.

The invention provides a low-allergy and anti-allergy plaster based on allantoin and a preparation method thereof. Relates to the field of skin medical supplies. The coconut oil acyl hydrolyzed collagen potassium of the plaster formed by the scheme can promote the proliferation of primary fibroblasts, so that the regeneration of the skin is accelerated from the primary fibroblasts, and the regeneration of the skin at the position covered by the plaster can be accelerated, thereby avoiding various reactions caused by the allergy of the position covered by the plaster. Besides, allantoin has good soothing, anti-inflammatory and repairing effects, can relieve the allergic state of the skin, and can effectively reduce the allergic feeling of a user; asiaticoside, trehalose and medical silicone can accelerate cell repair and effectively relieve allergic symptoms of a user. The optimal use proportion of the materials is obtained through experiments, the synergistic effect of the materials is the strongest under the proportion, the serious allergy phenomenon of a user can be weakened into the slight allergy phenomenon, and the moderate allergy phenomenon and the slight allergy phenomenon are eliminated intangibly.

The invention relates to the field of application of food functional factors, and particularly discloses a method for relieving cow milk allergy by using chitosan oligosaccharide and application. According to the method, chitosan oligosaccharide is given before sensitization, during sensitization or after sensitization; the chitosan oligosaccharide can be used for remarkably reducing the levels of serum IgE (Immunoglobulin E), IgG1 (Immunoglobulin G1), IL-4 (Interleukin-4), IL-10 (Interleukin-10), IL-17A (Interleukin-10), histamine and mast cell proteinase-1, and increasing the expression of IFN (Interferon)-gamma to regulate the immune balance of Th1 / Th2 / Th17; the alpha diversity and beta diversity of intestinal flora are improved, and the stable state of the flora is recovered; the allergy symptoms are relieved; the intestinal tract tissue injury is repaired. The chitosan oligosaccharide can be used for preparing functional foods or compositions for resisting cow milk allergy, and has application prospects in infant formula foods, solid beverages and dairy products.

The invention provides a preparation method and application of a scylla paramamosain allergen Scy p1 hypoallergenic derivative specific I gG antibody, a New Zealand white rabbit is subjected to immune treatment by using a Scy p1 hypoallergenic derivative, and antiserum is purified by using a Protei n A Sepharose affinity chromatography column, so that the purity of the antibody is greatly improved, and the obtained I gG antibody is ensured to have high specificity; the purified antibody is subjected to molecular weight detection through SDS-PAGE (Sodium Dodecyl Sulfate-Polyacrylamide Gel Electrophoresis), and an immunoglobulin heavy chain and an immunoglobulin light chain containing 50kDa and 25kDa are defined, so that the quality of the IgG antibody is verified, and a reliable basis is provided for subsequent application; the obtained specific I gG antibody effectively blocks combination of Scy p 1 and I gE in whole blood of a patient in vitro, effectively improves allergic symptoms of mice in vivo, ensures that the prepared I gG antibody is safer and is expected to be used for immunotherapy, and side effects possibly occurring in the treatment process are reduced.

Pro-toothpaste compositions formulated to receive a volume of allergen solution to provide toothpastes that exhibit efficacy for oral mucosal immunotherapy (OMIT) and acceptable consumer and product stability properties, along with kits of pro-toothpaste, allergen / extracts of allergens, and optionally compounding means and / or specialized toothbrushes are provided. Toothpastes suitable and effective for OMIT and methods for managing allergic symptoms and for reducing risk of allergy in people without symptoms employing the pro-toothpastes, toothpastes, and kits of the invention are also disclosed.

The invention discloses application of bifidobacterium animalis in relieving respiratory tract allergy symptoms, and belongs to the technical field of microorganisms. The technical problem to be solved is to provide the application of the bifidobacterium animalis in relieving the respiratory tract allergy symptoms, the key point of the technical scheme is the application of the bifidobacterium animalis subsp. Lactis BL-5M in relieving the respiratory tract allergy symptoms, and the preservation number of the bifidobacterium animalis subsp. Lactis BL-5M is CGMCC (China General Microbiological Culture Collection Center) No.33449. The medicine can act on the core mechanism of respiratory tract allergy, and the sneezing / cough frequency caused by respiratory tract stimulation reflex is reduced; the lung tissue enlargement mediated by allergic inflammation is relieved; the ratio of eosinophilic granulocytes in bronchoalveolus is reduced; the concentration of proinflammatory factors IL-4 and IL-5 in bronchoalveolus alveolus is reduced; inflammatory cell infiltration around the lung airway wall is reduced; the IgE content in a body circulation system or local tissues is reduced, meanwhile, the diversity of intestinal flora is improved, anti-inflammatory functional flora is accurately enriched, and the allergic asthma is improved in a targeted manner.