246 results about "SOY LECITHIN" patented technology

The invention relates to the technical field of pet food antioxidants, in particular to a compound pet food antioxidant containing plant polyphenol compounds and a preparation method of the compound pet food antioxidant. 10 to 20 parts of a grape seed extract; 8 to 15 parts of a rosemary extract; 5 to 10 parts of L-ascorbyl palmitate; 5 to 10 parts of alpha-tocopheryl acetate; 3-8 parts of citric acid; 8 to 15 parts of soybean lecithin; 20 to 30 parts of medium chain triglyceride; eGCG (epigallocatechin gallate) in the green tea contains a plurality of o-dihydroxyl structures, the grape seed procyanidine has a unique C6-C3-C6 skeleton, and carnosic acid in the rosemary belongs to a diterpenoid compound. Due to the diversity of the structure, the compound can play a role in different types of free radicals and oxidation reactions, and a broad-spectrum anti-oxidation network is formed.

The invention provides a feed domesticated siniperca chuatsi sperm low-temperature preservation and ultralow-temperature preservation method, which comprises the following steps: firstly, providing a siniperca chuatsi sperm low-temperature preservation diluent which comprises Hanks liquid, sodium chloride, soya bean lecithin, vitamin E, curcumin, melatonin and SOD (superoxide dismutase); and adding an anti-freezing protective agent into the low-temperature preservation diluent to obtain the ultralow-temperature preservation anti-freezing liquid for the siniperca chuatsi sperms. The siniperca chuatsi semen and the low-temperature preservation diluent are uniformly mixed, so that low-temperature preservation can be realized; the siniperca chuatsi semen is uniformly mixed with the cryopreservation anti-freezing liquid, so that cryopreservation can be realized. The siniperca chuatsi sperm low-temperature preservation diluent is preferably selected, low-temperature preservation of the siniperca chuatsi sperms can be achieved, ultralow-temperature preservation can be conducted after an anti-freezing protective agent is added, the persistence of the preservation time of the siniperca chuatsi sperms can be guaranteed, the protection effect on the sperms is good, and the activation rate and activity of the unfrozen sperms are high.

The invention discloses a macrophage-targeting inhalable nano material, a preparation method thereof and application of the inhalable nano material in treatment of sepsis myocarditis, and belongs to the technical field of medicines. The nano-material is a nano-liposome, the nano-liposome comprises a mannose modified nano-liposome microsphere, and the mannose modified nano-liposome microsphere comprises a liposome skeleton shell layer, a drug and a targeting layer; the liposome skeleton shell layer comprises soybean lecithin and cholesterol; the medicine comprises quercetin and TPPU (Thermoplastic Polyurethane); and the targeting layer is formed by connecting mannose modified DSPE-PEG2000 to the outer surface of the liposome skeleton shell layer. The nano material can accurately target macrophages at a cardiac inflammation part, has a multi-target-point synergistic effect, is more convenient and faster in administration, remarkably improves the safety and comprehensively improves the treatment effect.

The invention provides an antistatic agent for fuel oil and a preparation method thereof, and belongs to the technical field of petrochemical engineering, and the preparation method comprises the following steps: S1, adding soybean lecithin and chlorosulfonic acid into dichloroethane, uniformly mixing, under the protection of nitrogen, heating and stirring for reaction, neutralizing reaction liquid, and performing rotary evaporation to obtain sulfonated soybean lecithin; the preparation method comprises the following steps: adding sulfonated soybean lecithin and ethidene diamine into absolute ethyl alcohol, then adding p-toluenesulfonic acid, heating and stirring for reaction, and carrying out reduced pressure distillation to obtain modified soybean lecithin; s2, dispersing the SiO2 particles in absolute ethyl alcohol, adding KH-550, and performing ultrasonic treatment, centrifugation and drying to obtain pretreated SiO2 particles; and uniformly mixing the modified soybean lecithin and the pretreated SiO2 particles, adding the mixture into a supercritical fluid reactor, heating and pressurizing, ultrasonically dispersing, and drying to obtain the antistatic agent. The antistatic agent has the advantages of good dispersibility, strong stability and strong antistatic capability.

The invention relates to a novel camellia saponin derivative feed additive and a preparation method thereof, and belongs to the technical field of feed additives. The modified chitosan is used in the flocculation and impurity removal process for preparing the camellia oleifera saponin derivative, and the modified chitosan reduces the loss of effective components caused by flocculation and impurity removal while ensuring the purity of the camellia oleifera saponin derivative; soybean lecithin and gelatin are used as capsule walls, the camellia saponin derivative and pyropheophorbide-a are wrapped, pyropheophorbide-a can generate singlet oxygen under excitation of visible light, phospholipid bonds are damaged, the camellia saponin derivative is released, and therefore the slow release effect is achieved; the novel camellia saponin derivative feed additive prepared by the invention has good antibacterial property and timeliness.

The invention provides eye protection liquid for improving eye microcirculation and a preparation method thereof, and belongs to the technical field of medical configuration products. The composition comprises the following components: surface-modified magnetic nanoparticles, a calendula extract, a fermented dogwood extract, xanthophyll, taurine, sodium hyaluronate, hydrolyzed sodium hyaluronate, soya bean lecithin, borneol and fermented vegetable oil. The efficiency of active ingredients is improved through a double-fermentation technology, magnetic targeting and multi-channel compounding are combined, and the preparation method has remarkable advantages in the field of improving periorbital microcirculation. The traditional Chinese medicine composition has an obvious relieving effect on asthenopia and dry skin around eyes; the components of the eye microcirculation eye protection liquid are mild, and adverse reactions such as allergy cannot be caused.

This invention discloses a method for preparing a diglyceride nanostructured lipid carrier hydrogel, comprising the following steps: mixing vegetable oil and diglyceride at a mass ratio of 1:1-3 as phase A; using an aqueous solution of soybean lecithin, tea saponin, and glycerol as phase B; adding phase B to phase A, followed by emulsification, ultrasonic treatment, and finally cooling to room temperature to obtain a diglyceride nanostructured lipid carrier; adding the diglyceride nanostructured lipid carrier to the hydrogel and mixing to obtain the diglyceride nanostructured lipid carrier hydrogel. This invention also discloses the application of the above-mentioned diglyceride nanostructured lipid carrier hydrogel. The diglyceride nanostructured lipid carrier hydrogel of this invention not only has good sun protection, antioxidant, and anti-glycation properties, but can also encapsulate unstable cosmetic raw materials.

The invention belongs to the technical field of traditional Chinese medicines and cosmetics, and particularly relates to eutectic resveratrol, a liposome thereof, a preparation method and application of the eutectic resveratrol. The eutectic resveratrol is prepared from the following raw materials: resveratrol, amino acid and glycerol; the amino acid is selected from one of proline, lysine and arginine. The eutecticevaporate resveratrol liposome is prepared from the following raw materials: soybean phospholipid, cholesterol and eutecticevaporate resveratrol, the mass ratio of the soybean phospholipid to the cholesterol is (1-9): 1, and the mass ratio of the sum of the mass of the soybean phospholipid and the cholesterol to the mass of the eutecticevaporate resveratrol is 1: (0.5-2). A method capable of improving the solubility and stability of resveratrol is found, the eutectic resveratrol liposome which is stable in particle size and PDI and excellent in zeta potential and has certain anti-oxidation and antibacterial performance is prepared, the solubility, stability and bioavailability of resveratrol (RES) are improved, and the resveratrol liposome is suitable for being used as an anti-inflammatory drug. And a new thought is provided for further development and application research of resveratrol (RES).

The present invention relates to the technical field of eye drops, and specifically discloses a kind of wetting boric acid eye drops. The present invention also discloses a preparation method of the above-mentioned wetting boric acid eye drops, boric acid, chlorhexidine gluconate solution, and calcium disodium edetate are added to water, and stirred at 60-70°C to obtain a boric acid complex; sodium hyaluronate and sodium alginate are added to water and stirred, and hypromellose is added, and stirred at 30-40°C to obtain a hypromellose complex; soy lecithin, cholesterol, and ethylparaben are added to chloroform and stirred to obtain phase A; collagen and carboxymethyl chitosan are added to citric acid aqueous solution and stirred to obtain phase B; phase A is added to phase B under stirring, ultrasonic treatment, 50-60°C vacuum rotary evaporation to remove chloroform, citric acid aqueous solution is added for hydration, ultrasonic treatment, and filtration to obtain liposomes; boric acid complex, hypromellose complex, and liposomes are mixed evenly, and the pH value of the adjustment system is 6.5-7.5.

This invention discloses a recombinant collagen liposome, its preparation method, and its application. The recombinant collagen liposome comprises 1-10 parts recombinant type XVII collagen, 2-15 parts soybean lecithin, 0.3-2 parts tocopherol, 0.5-7 parts antioxidant, 20-54 parts glycerol, and Dendrobium officinale enzymatic hydrolysate to a total weight of 100 parts. This invention improves the stability and transdermal absorption of recombinant type XVII collagen by encapsulating it in liposomes. The prepared recombinant collagen liposomes not only have a high encapsulation efficiency but also retain excellent barrier repair and anti-wrinkle effects after 8 weeks of storage, making them suitable for use in cosmetics.

The present invention belongs to the field of medical technology, and in particular to a hydrogel dressing for promoting wound healing and a preparation method thereof. The hydrogel dressing includes the following raw materials in parts by weight: 10-18 parts of gel matrix, 1-5 parts of silk fibroin, 0.3-0.8 parts of scutellariae, 0.1-0.5 parts of diphenylethylene glycosides, 0.4-0.8 parts of modified soybean lecithin, 0.5-1 parts of trehalose, and 80-100 parts of deionized water. The hydroxyl groups in the modified soybean lecithin and the amino groups of the components such as chitosan in the gel matrix form hydrogen bonds, thereby improving the mechanical properties of the hydrogel dressing. In addition, the modified soybean lecithin can also increase the water content of the stratum corneum of the skin, which is beneficial to the repair of scars after wound healing. And the results of wound healing experiments show that the use of scutellariae and diphenylethylene glycosides can effectively promote wound healing.

The present invention provides a compound feed for freshwater fish and a preparation method thereof, comprising the following raw materials in parts by weight: 39-44 parts of corn protein powder, 22-34 parts of cottonseed protein powder, 5.4-9.2 parts of black soldier fly larva powder, 11-23 parts of fish oil, 20-30 parts of Schizochytrium powder, 7.5-12.4 parts of soy lecithin powder, 4-10 parts of maltitol, 8-12 parts of sodium butyrate, 8-15 parts of Chinese herbal medicine liquid, 0.2-0.8 parts of compound fermenting agent. Through steps such as raw material mixing, Chinese herbal medicine liquid fermentation, homogenization, puffing and spray drying in sequence, the feed quality control is carried out, so that the compound feed has a relatively high absorption rate and palatability, ensures the intake of the components of the Chinese herbal medicine fermentation liquid, significantly improves the survival rate and growth rate of freshwater fish, and has remarkable economic benefits.

The invention belongs to the field of cosmetics, and discloses a ceramide E-containing polypeptide composition and application thereof. The polypeptide composition containing ceramide E is prepared from the following components in parts by mass: 5 to 10 parts of ceramide E, 3 to 6 parts of fibronectin, 3 to 6 parts of palmitoyl pentapeptide-4, 1.5 to 3.5 parts of ergothioneine, 20 to 40 parts of oil-phase solvent, 1.5 to 4.5 parts of caprylic / capric triglyceride, 0.5 to 2.5 parts of soybean lecithin, 0.5 to 1.5 parts of polysorbate-80, 0.1 to 0.5 part of cholesterol and the balance of water, wherein the total mass part of the water is 100. In the polypeptide composition disclosed by the invention, ceramide E, fibronectin, ergothioneine and palmitoyl pentapeptide-4 are mutually promoted and have synergistic interaction, and a final product shows very good repairing and antioxidant effects.

A composition comprising a glucagon-like peptide 1 (GLP-1) agonist for sublingual or buccal administration, wherein the composition comprises one or more agents selected from the group consisting of; sodium glycodeoxycholate; sodium deoxycholate; carboxymethyl cellulose; sodium alginate; SNAC (salcaprozate sodium); a non-ionic ester alkoxylate (or alkanoic acid ester alkoxylate); and soy lecithin.

The invention relates to the field of cell culture, in particular to a serum-free induced adipogenic differentiation culture medium for fish stem cells and application of the serum-free induced adipogenic differentiation culture medium. The culture medium consists of a basic culture medium and a cell culture auxiliary factor combination, the basic culture medium is one of a DMEM (Dulbecco's Modified Eagle Medium) and a DMEM / F12 culture medium; the cell culture auxiliary factor combination is prepared from oleic acid, soya bean lecithin, vitamin C phosphate, beta cyclodextrin, transferrin, saikoside A, psoralen flavanone methyl ether, dehydroabietic acid and phenyllactic acid. The culture medium suitable for serum-free induced adipogenic differentiation of fish stem cells is obtained by adding a cell culture auxiliary factor combination to replace serum in a traditional adipose precursor cell adipogenic induced differentiation culture medium and dexamethasone IBMX serving as a core component of traditional adipogenic differentiation cocktail, the bottleneck problem in the prior art is solved, and the culture medium is suitable for serum-free induced adipogenic differentiation of fish stem cells. And reliable technical support is also provided for large-scale production of cell culture fish meat.

The invention relates to a eugenol liposome / chitosan / polyoxyethylene hydrophobic electrospun fibrous membrane and a preparation method thereof, and the method comprises the following steps: based on soybean lecithin and cholesterol, adding eugenol and Tween 80, preparing a lipid solution, injecting the lipid solution into water or a phosphate buffer solution, and preparing an eugenol liposome suspension with the eugenol embedding rate greater than 88%; preparing a cross-linked chitosan acetic acid solution based on chitosan and a cross-linking agent; preparing a polyoxyethylene acetic acid solution, and mixing the cross-linked chitosan acetic acid solution with the polyoxyethylene acetic acid solution to obtain a base material spinning solution; mixing the eugenol liposome suspension with a base material spinning solution to prepare a final spinning solution, and preparing the eugenol liposome / chitosan / polyoxyethylene hydrophobic electrospinning fiber membrane by adopting an electrostatic spinning method. The embedding rate of eugenol is high, the water contact angle of the fiber membrane can reach 90 degrees or above, the slow release effect on eugenol is good, and the antibacterial and fresh-keeping effects are improved.

The invention discloses a feed for promoting gonad development of sturgeons and a preparation method of the feed. Comprising the following raw materials: 35-40 parts of fish meal, 13-17 parts of fermented soybean meal, 5-10 parts of chicken meal, 3-5 parts of corn protein powder, 7-12 parts of a compound additive, 4-8 parts of a plant extract, 5-8 parts of cuttlefish meal, 3-6 parts of euphausia superba meal, 3-5 parts of shell powder, 5-10 parts of fish oil, 3-5 parts of spirulina, 3-4 parts of microcrystalline cellulose, 1.5-2.5 parts of fumaric acid, 2-3 parts of soybean lecithin and 1.5-2 parts of monocalcium phosphate. And 0.8 to 1.1 parts of a compound premix. According to the feed, the sturgeons can obtain the most sufficient nutrition in the gonad development stage, so that gonad development is better promoted, the egg laying amount of the sturgeons can be increased, and the nutritional value and quality of eggs can be improved.

The invention discloses a moisturizing anti-wrinkle polypeptide composition as well as a preparation method and application thereof, and relates to the technical field of daily chemical materials. The invention discloses a preparation method of a moisturizing and anti-wrinkle polypeptide composition, which comprises the following steps: uniformly stirring meadowfoam seed oil, caprylic acid / capric acid / succinic triglyceride and polypeptide liposome to obtain the moisturizing and anti-wrinkle polypeptide composition, wherein the polypeptide liposome is prepared by taking a combination of soybean lecithin, modified cholesterol and cholesterol as a capsule material and taking acetyl hexapeptide-8, snake venom peptide and a blue copper peptide compound as a core material through an ethanol injection method. The modified cholesterol is obtained by modifying cholesterol, the modified cholesterol is added into the capsule material, the defects that an existing liposome material is prone to aggregation and leakage, poor in stability and the like are effectively overcome, and the prepared material is good in stability, capable of being slowly released, high in skin retention amount and capable of being more easily absorbed by skin cells; the function of obviously delaying skin aging is realized.

The invention relates to the field of cosmetics, and discloses a moisturizing and anti-aging micro-capsule composition for cosmetics and a preparation method thereof.The micro-capsule composition comprises a dispersion matrix and a flexible bead, and the flexible bead comprises an active material and a micro-capsule wall, the active materials comprise a centella asiatica extract, a cynanchum atratum extract, an olive leaf extract, a scutellaria baicalensis extract and glycerol tri (ethylhexanoate) ester, and the microcapsule wall comprises soybean lecithin, modified polylactic acid, chondrus crispus and calcium alginate. The modified polylactic acid is prepared by carrying out graft copolymerization reaction on chitosan and L-lactide in chlorinated 1-butyl-3-methylimidazole and then carrying out graft modification by using L-arginine, the active material is wrapped in the capsule wall of the microcapsule to form the flexible bead, and the flexible bead is uniformly suspended in the dispersion matrix; the cosmetics are endowed with better anti-wrinkle and moisturizing effects.

The present invention belongs to the technical field of semen cryopreservation, and more specifically, relates to sheep semen freezing solution and semen preservation method. The sheep semen freezing solution components of the present invention include Tris, citric acid, fructose, lactose, trehalose, penicillin, streptomycin, soy lecithin, nobiletin, glycerol and water. By using a specific content of nobiletin as an effective antioxidant component of a sheep sperm cryopreservative, it plays an antioxidant role when the sperm is frozen, making the sperm more stable during the cryopreservation process. After adding nobiletin, the vitality and motility of sheep sperm after freezing and thawing can be significantly improved. It effectively reduces the oxidative stress damage of sperm during the freezing process and improves the antioxidant capacity of sperm.

The application provides a topical traditional Chinese medicine composition for treating vulvar leukoplakia and a preparation method thereof. The composition is composed of traditional Chinese medicinal materials such as angelica, cortex psoraleae and barks of dictamnus dasycarpus, and a penetration enhancer, an activating agent and a moisturizing agent. The penetration enhancer is composed of soybean lecithin, phosphatidylethanolamine and cholesterol, the activating agent is sodium cholate, sodium deoxycholate and sodium taurocholate, and the moisturizing agent is eucalyptus oil. The drugs are compatible to exert the effects of clearing heat and drying dampness, cooling blood and nourishing yin, activating blood and resolving stasis, warming yang and dispelling cold and supporting healthy qi and tonifying the body resistance. The traditional Chinese medicine composition is prepared through supercritical extraction, micronization treatment, solution preparation and intermittent ultrasonic homogenization. The traditional Chinese medicinal materials are used for treating the etiology, pathogenesis and symptoms of vulvar leukoplakia, the penetration enhancer reduces the skin barrier function, the activating agent enhances the drug activity and permeability, and the moisturizing agent maintains the skin moisture and assists in anti-inflammation. The clinical application effectively relieves the symptoms of patients with vulvar leukoplakia, improves the pathological state of local skin and improves the treatment effect, thereby providing a new effective option for the treatment of vulvar leukoplakia.

The present invention relates to the technical field of liposomes, and in particular to a supramolecular astaxanthin liposome and a preparation method and application thereof. The preparation method comprises: mixing astaxanthin with a cationic precursor in a solvent to react to obtain supramolecular astaxanthin; reacting the supramolecular astaxanthin, soybean lecithin and a surfactant to obtain the supramolecular astaxanthin liposome. The preparation method has simple synthesis steps, convenient post-treatment, high purity and high yield of the obtained product. The obtained supramolecular astaxanthin liposome has the antioxidant and repairing effects and biological activities of astaxanthin and lipids, effectively improves the solubility and skin permeability of astaxanthin and can improve its biological activity, and has potential application value in transdermal administration and delivery.

The invention belongs to the technical field of compositions, and provides a moisture-retaining and eye-moistening composition as well as a preparation method and application thereof. According to the moisturizing eye-moistening composition provided by the invention, the soybean lecithin, the retinol palmitate lipidosome, the xanthophyll, the oligomeric hyaluronic acid and the ethylenediamine tetraacetic acid in a specific ratio are combined, and all the components can play a good synergistic effect, so that the effects of relieving asthenopia symptoms, protecting eyesight and maintaining normal vision are improved; the eye drops can improve and relieve eye dryness and eye astringency symptoms caused by various reasons (such as fatigue, wearing of contact lenses, use of electronic products, excessive use of eyes and the like).

The invention discloses a preparation method of phospholipid type DHA (docosahexaenoic acid) and application of the phospholipid type DHA in preparation of products for improving allergy symptoms, and belongs to the technical field of preparation and application of the phospholipid type DHA. Obtaining free DHA from the fish oil; soybean lecithin and free DHA are mixed, n-hexane is added for ultrasonic dissolution, enzyme is added after dissolution, nitrogen is filled for sealing for reaction, enzyme is removed after the reaction is finished, an organic solvent is removed from reaction liquid through rotary evaporation, mixed grease is obtained, and the phospholipid type DHA is obtained through purification. In the aspect of improving allergy, the phospholipid DHA prepared by the invention has a better mixing effect than fish oil and soybean lecithin, and has a good application prospect in the aspect of preparing functional foods, medicines or medicine carriers.

The invention discloses a tropical basil essential oil liposome for targeting breast cancer. The liposome is composed of a breast cancer targeting liposome skeleton and tropical basil essential oil. Wherein the breast cancer targeted liposome skeleton is composed of soybean lecithin, cholesterol, and vasoactive intestinal peptide modified distearoyl phosphatidyl ethanolamine-polyethylene glycol 2000. The mass ratio of the tropical basil essential oil to the liposome skeleton in the liposome is 1: 50. The liposome carrying the tropical basil essential oil for targeting the breast cancer, prepared by the invention, has high affinity to breast cancer cells and high cell uptake, can remarkably inhibit proliferation, migration and invasion of triple-negative breast cancer cells, remarkably improves the effect of the tropical basil essential oil on resisting triple-negative breast cancer, reduces adverse reactions, and has a remarkable progress. The preparation method of the liposome is simple, the raw materials are easy to obtain, the anti-cancer effect is remarkable, and the liposome has good application value and market prospect.

The present application relates to the technical field of vaccine production, in particular to a preparation method of a Sapindus saponin veterinary vaccine adjuvant, comprising: determining the limit concentration of Sapindus saponin with a hemolysis rate lower than 5% and preparing the vaccine adjuvant; determining the limit concentration of Sapindus saponin with a hemolysis rate lower than 5% against red blood cells by spectrophotometry; preparing the vaccine adjuvant by dialysis; and the vaccine adjuvant contains soybean lecithin and cholesterol in a weight ratio of 1:1. The present application first determines the safe use concentration of Sapindus saponin through a standard hemolysis experiment, ensures that the hemolysis rate of the prepared adjuvant meets the safety requirements, and avoids adverse reactions after injection; at the same time, the present application uses soybean lecithin and cholesterol as raw materials, and prepares the nano-liposome adjuvant embedding Sapindus saponin by dialysis, which does not require complex process operation, has low preparation cost, and has safety and practicability, and can effectively assist the vaccine to induce the body to produce stronger immune response and improve the protection effect of the vaccine.

The invention discloses a traditional Chinese medicine flexible liposome compound for treating alopecia as well as a preparation method and application thereof, and belongs to the technical field of Chinese herbal medicines. The composition comprises a traditional Chinese medicine composition and a flexible liposome wrapping an extract prepared from the traditional Chinese medicine composition, the traditional Chinese medicine composition is prepared from the following components in parts by weight: 0.1 to 15 parts of radix polygoni multiflori preparata, 0.1 to 10 parts of flos carthami, 0.1 to 15 parts of folium mori, 0.1 to 15 parts of semen sesami nigrum, 0.1 to 10 parts of herba ecliptae, 0.1 to 10 parts of cacumen biotae and 0.1 to 5 parts of radix sophorae flavescentis. Through the synergistic effect of the traditional Chinese medicine components, the composition can play an extremely remarkable effect on hair growth. Meanwhile, the flexible lipidosome prepared from soybean lecithin, cholesterol and a flexible agent can enhance permeation and absorption of functional components, and the hair growing and hair loss preventing effects of the flexible lipidosome are further improved.

The invention discloses a nano-liposome and a preparation method and application thereof, and belongs to the technical field of pharmaceutical preparations, the preparation method comprises the following steps: S1, mixing soybean lecithin, cholesterol and Tween 80, dissolving in absolute ethyl alcohol, stirring until complete dissolution, and transferring the mixed solution into a rotary evaporator to obtain a lipid film; and S2, adding a resveratrol solution, a nisin solution and a 0.03 M phosphate buffer solution into the lipid membrane obtained in the step S1, after the membrane is completely dissolved, transferring to a cell superfine grinding instrument for treatment, adding a phosphatidyl ethanolamine-polyethylene glycol 2000 aqueous solution with the mass fraction of 3%, uniformly mixing by vortex, standing, and filtering by a filtering membrane to obtain the lipid membrane. The polyethylene glycol modified nano liposome RN-NPs is obtained. As an oral targeted drug delivery system, the nano-liposome disclosed by the invention not only improves the effective utilization rate of drugs, but also remarkably improves the safety and effectiveness of treating staphylococcus aureus enteritis.

This application relates to the field of veterinary drug technology, and discloses a transdermal absorption-enhancing ointment and its preparation process. The ointment components include white petrolatum, anhydrous lanolin, caprylic / capric triglycerides, hydrophobic fumed silica, and a highly fluid active permeation-enhancing phase. The permeation-enhancing phase contains active drugs and soybean lecithin, which self-assemble to form an inverse micelle aggregate. Soybean lecithin cross-links with the silanol groups on the surface of silica to form an intermolecular hydrogen bond network, constructing a sterically hindered framework within a continuous lipid matrix to prevent the polar drug-loaded phase from permeating and separating upon heating. Simultaneously, the inverse micelle structure effectively improves the transdermal absorption rate of the drug. The preparation process controls the lipid crystallization kinetics through slow cooling under negative pressure and micro-shear dynamic rheology. This invention solves the problems of easy precipitation upon heating, low transdermal efficiency, and poor rheological properties in traditional ointments, resulting in a product with a stable physical structure and good pseudoplastic texture.

The invention relates to the technical field of emulsion explosives, and particularly discloses a formula and a preparation method of an underground mine blasting mixed emulsion explosive. The underground mine blasting mixed emulsion explosive comprises the following components in percentage by mass: 73-78% of ammonium nitrate, 3-5% of sodium nitrate, 0.2-0.4% of thiourea, 2-5% of an oil phase component, 1-3% of a compound emulsifier, 0.3-0.5% of a sensitizer, 0.8-1.5% of hollow glass balls and the balance of water, the compound emulsifier is composed of sorbitan monooleate, polyisobutylene succinimide and soya bean lecithin, and the sensitizer is composed of ethanolamine nitrate and phosphoric acid; according to the invention, by optimizing the proportion of each component, adopting an efficient emulsification process under a mild condition and synergistically optimizing each component, the product has good explosion performance and safety and can adapt to different mine environments, meanwhile, the stability of the emulsion explosive in a low-temperature environment is ensured, and the problem of miss-fire explosion in winter is effectively overcome.