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96 results about "SOY LECITHIN" patented technology

Application of inhalable nanomaterial of targeted macrophages in preparation of medicine for treating sepsis myocarditis

The invention discloses a macrophage-targeting inhalable nano material, a preparation method thereof and application of the inhalable nano material in treatment of sepsis myocarditis, and belongs to the technical field of medicines. The nano-material is a nano-liposome, the nano-liposome comprises a mannose modified nano-liposome microsphere, and the mannose modified nano-liposome microsphere comprises a liposome skeleton shell layer, a drug and a targeting layer; the liposome skeleton shell layer comprises soybean lecithin and cholesterol; the medicine comprises quercetin and TPPU (Thermoplastic Polyurethane); and the targeting layer is formed by connecting mannose modified DSPE-PEG2000 to the outer surface of the liposome skeleton shell layer. The nano material can accurately target macrophages at a cardiac inflammation part, has a multi-target-point synergistic effect, is more convenient and faster in administration, remarkably improves the safety and comprehensively improves the treatment effect.
Owner:RENJI HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE

Novel camellia saponin derivative feed additive and preparation method thereof

The invention relates to a novel camellia saponin derivative feed additive and a preparation method thereof, and belongs to the technical field of feed additives. The modified chitosan is used in the flocculation and impurity removal process for preparing the camellia oleifera saponin derivative, and the modified chitosan reduces the loss of effective components caused by flocculation and impurity removal while ensuring the purity of the camellia oleifera saponin derivative; soybean lecithin and gelatin are used as capsule walls, the camellia saponin derivative and pyropheophorbide-a are wrapped, pyropheophorbide-a can generate singlet oxygen under excitation of visible light, phospholipid bonds are damaged, the camellia saponin derivative is released, and therefore the slow release effect is achieved; the novel camellia saponin derivative feed additive prepared by the invention has good antibacterial property and timeliness.
Owner:GUANGDONG GUANGMU ANIMAL HEALTH PROD CO LTD

Recombinant collagen liposome and preparation method and application thereof

This invention discloses a recombinant collagen liposome, its preparation method, and its application. The recombinant collagen liposome comprises 1-10 parts recombinant type XVII collagen, 2-15 parts soybean lecithin, 0.3-2 parts tocopherol, 0.5-7 parts antioxidant, 20-54 parts glycerol, and Dendrobium officinale enzymatic hydrolysate to a total weight of 100 parts. This invention improves the stability and transdermal absorption of recombinant type XVII collagen by encapsulating it in liposomes. The prepared recombinant collagen liposomes not only have a high encapsulation efficiency but also retain excellent barrier repair and anti-wrinkle effects after 8 weeks of storage, making them suitable for use in cosmetics.
Owner:GUANGZHOU YUANJI CELL BIOTECHNOLOGY CO LTD

An external-use traditional Chinese medicine composition for treating vulvar leukoplakia and a preparation method thereof

The application provides a topical traditional Chinese medicine composition for treating vulvar leukoplakia and a preparation method thereof. The composition is composed of traditional Chinese medicinal materials such as angelica, cortex psoraleae and barks of dictamnus dasycarpus, and a penetration enhancer, an activating agent and a moisturizing agent. The penetration enhancer is composed of soybean lecithin, phosphatidylethanolamine and cholesterol, the activating agent is sodium cholate, sodium deoxycholate and sodium taurocholate, and the moisturizing agent is eucalyptus oil. The drugs are compatible to exert the effects of clearing heat and drying dampness, cooling blood and nourishing yin, activating blood and resolving stasis, warming yang and dispelling cold and supporting healthy qi and tonifying the body resistance. The traditional Chinese medicine composition is prepared through supercritical extraction, micronization treatment, solution preparation and intermittent ultrasonic homogenization. The traditional Chinese medicinal materials are used for treating the etiology, pathogenesis and symptoms of vulvar leukoplakia, the penetration enhancer reduces the skin barrier function, the activating agent enhances the drug activity and permeability, and the moisturizing agent maintains the skin moisture and assists in anti-inflammation. The clinical application effectively relieves the symptoms of patients with vulvar leukoplakia, improves the pathological state of local skin and improves the treatment effect, thereby providing a new effective option for the treatment of vulvar leukoplakia.
Owner:GUANGDONG PROVINCIAL HOSPITAL OF TRADITIONAL CHINESE MEDICINE HAINAN HOSPITAL

Preparation method of a vaccine adjuvant for animals containing soapberry saponin

The present application relates to the technical field of vaccine production, in particular to a preparation method of a Sapindus saponin veterinary vaccine adjuvant, comprising: determining the limit concentration of Sapindus saponin with a hemolysis rate lower than 5% and preparing the vaccine adjuvant; determining the limit concentration of Sapindus saponin with a hemolysis rate lower than 5% against red blood cells by spectrophotometry; preparing the vaccine adjuvant by dialysis; and the vaccine adjuvant contains soybean lecithin and cholesterol in a weight ratio of 1:1. The present application first determines the safe use concentration of Sapindus saponin through a standard hemolysis experiment, ensures that the hemolysis rate of the prepared adjuvant meets the safety requirements, and avoids adverse reactions after injection; at the same time, the present application uses soybean lecithin and cholesterol as raw materials, and prepares the nano-liposome adjuvant embedding Sapindus saponin by dialysis, which does not require complex process operation, has low preparation cost, and has safety and practicability, and can effectively assist the vaccine to induce the body to produce stronger immune response and improve the protection effect of the vaccine.
Owner:LUDONG UNIVERSITY

A transdermal absorption promoting ointment and a preparation process thereof

This application relates to the field of veterinary drug technology, and discloses a transdermal absorption-enhancing ointment and its preparation process. The ointment components include white petrolatum, anhydrous lanolin, caprylic / capric triglycerides, hydrophobic fumed silica, and a highly fluid active permeation-enhancing phase. The permeation-enhancing phase contains active drugs and soybean lecithin, which self-assemble to form an inverse micelle aggregate. Soybean lecithin cross-links with the silanol groups on the surface of silica to form an intermolecular hydrogen bond network, constructing a sterically hindered framework within a continuous lipid matrix to prevent the polar drug-loaded phase from permeating and separating upon heating. Simultaneously, the inverse micelle structure effectively improves the transdermal absorption rate of the drug. The preparation process controls the lipid crystallization kinetics through slow cooling under negative pressure and micro-shear dynamic rheology. This invention solves the problems of easy precipitation upon heating, low transdermal efficiency, and poor rheological properties in traditional ointments, resulting in a product with a stable physical structure and good pseudoplastic texture.
Owner:SHAN DONG DE QING ZHI YAO YOU XIAN ZE REN GONG SI

A method for preparing hydrophilic drug nanoliposomes based on a microfluidic-low shear coupling double emulsion method and hydrophilic drug nanoliposomes

PendingCN122272506AOil phaseBiology
This invention discloses a method for preparing hydrophilic drug nanoliposomes based on microfluidic-low-shear coupling double emulsion and the hydrophilic drug nanoliposomes prepared according to the following method: (1) Prepare aqueous solutions of hydrophilic drugs and chloroform solutions of soybean lecithin respectively; (2) Add the chloroform solution of soybean lecithin to the chamber as the oil phase, and inject the aqueous solution of hydrophilic drugs into the oil phase in the low-shear stirring field through a microtube under low-speed stirring and shearing, and collect the W / O pre-emulsion sample; (3) Use the W / O pre-emulsion sample as the dispersed phase, and inject it into the external aqueous phase in the same way as in step (2), and emulsify it under low-speed stirring and shearing to form a W / O / W double emulsion; (4) Remove the chloroform by vacuum evaporation of the W / O / W double emulsion to obtain hydrophilic drug nanoliposomes. The prepared Ganoderma lucidum polysaccharide nanoliposomes have a particle size controlled at 200-300 nm, a polydispersity index of about 0.2, and an encapsulation efficiency of more than 70%, which is more than twice that of the traditional thin film hydration method. It solves the technical problem of low encapsulation efficiency of water-soluble macromolecular Ganoderma lucidum polysaccharides.
Owner:CHONGQING MEDICAL & PHARMA COLLEGE

Ophthalmic composition comprising at least one nicotinic acetylcholine receptor modulator for topical application to eye to prevent or treat inflammation of eye

The present invention relates to ophthalmic compositions comprising at least one substance of at least one nicotinic acetylcholine receptor (nAChR) modulator, in particular varenicline, megamine and derivatives thereof, and / or the endogenous Kennedy metabolic pathway, as well as salts and derivatives or pharmaceutically acceptable salts of these substances, and choline-containing phospholipids, salts and derivatives of these substances. From these groups, particularly preferred are choline, phosphocholine, CDP-choline (citicoline), phosphatidylcholine (e.g. Lecithin having a phosphatidylcholine content of > = 80% by weight, e.g. Soybean lecithin), ethanolamine, phosphoethanolamine, CDP-ethanolamine, phosphatidylethanolamine, L-alpha-glycerophosphorylcholine, phosphatidylcholine, phosphatidylethanolamine.
Owner:URSAPHARM ARZNEIMITTEL

Loratadine oral liquid and production process thereof

The invention discloses a loratadine oral liquid and a production process thereof. Comprising the following raw materials in parts by weight: 0.5 to 0.6 part of loratadine, 5 to 6 parts of beta-cyclodextrin, 10 to 12 parts of polyethylene glycol 400, 8 to 10 parts of glycerol, 6 to 8 parts of propylene glycol, 0.3 to 0.4 part of sucralose, 0.2 to 0.3 part of stevioside, 15 to 18 parts of maltitol, 1 to 1.2 parts of citric acid, 0.5 to 0.6 part of malic acid, 0.1 to 0.15 part of disodium EDTA (Ethylene Diamine Tetraacetic Acid), 0.8 to 1 part of vitamin C, 0.3 to 0.4 part of xanthan gum, 0.5 to 0.6 part of sodium carboxymethyl cellulose and 0.4 to 0.5 part of lemon essence. The composition comprises the following components in parts by weight: 0.1-0.15 part of menthol, 2-3 parts of hawthorn extract, 1.2-1.5 parts of soya bean lecithin and the balance of purified water, totaling 100 parts. The loratadine is clathrated by the beta-cyclodextrin, the absorption promotion effect of the soya bean lecithin is combined, and the compound sweetening agent, the compound stabilizer and the natural flavor substance are matched, so that the problems of poor solubility and obvious bitter taste of the loratadine are solved, and the stability and bioavailability of the product are also improved.
Owner:JIANGSU CHENPAI BOND PHARM CO LTD

Prebiotic soft fried dough twist and making method thereof

The invention discloses prebiotic soft fried dough twists and a making method thereof, and belongs to the technical field of food. The fried dough twist disclosed by the invention is prepared from the following raw materials in parts by mass: 132 to 169.5 parts of a dough base material, 5 to 6 parts of resistant dextrin, 7 to 9 parts of fructo-oligosaccharide microcapsules, 6 to 8 parts of isomaltitol, 1.5 to 2 parts of stachyose, 0.5 to 1.0 part of soybean lecithin and 0.01 to 0.03 part of vitamin E. The prebiotic retention rate is synergistically increased through microcapsule coating and a making process, the aging resistance of the fried dough twist is improved through synergistic moisturizing of resistant dextrin and fructo-oligosaccharide microcapsules, white granulated sugar is partially replaced by isomaltitol, stachyose and other sugar parts with low glycemic index, and the taste of the fried dough twist is improved. And the resistant dextrin with high dietary fiber content and the fructo-oligosaccharide prebiotics are matched, so that the product not only meets the sweet taste requirement, but also meets the healthy diet pursuit of modern consumers on low sugar, high fiber and high prebiotics.
Owner:SHANDONG BAILONG CHUANGYUAN BIO TECH CO LTD

Preparation method of biomass-based slow release agent for repairing polycyclic aromatic hydrocarbon polluted underground water

The invention discloses a preparation method of a biomass-based slow-release agent for repairing polycyclic aromatic hydrocarbon polluted underground water, which comprises the following steps: 1, preparation of soybean milk fermentation liquor: weighing soybeans, soaking the soybeans in ultrapure water according to a solid-to-liquid ratio of 1: 20-1: 50 for 12-48 hours, pulping, and adding ultrapure water until the volume is 500mL to obtain a soybean milk matrix; inoculating 10mL of polycyclic aromatic hydrocarbon polluted underground water indigenous microorganism bacterial liquid into the soybean milk matrix, and carrying out closed fermentation under a constant-temperature oscillation condition, 2, preparation of a multifunctional composite slow-release agent: weighing 35-60 parts by weight of FeSO4. 7H2O, 1-5 parts by weight of rhamnolipid, 5-10 parts by weight of humic acid, 1-5 parts by weight of methionine, 5-10 parts by weight of peanut peptide, 1-10 parts by weight of soybean lecithin, 3-10 parts by weight of a yeast extract and 40-60 parts by weight of the soybean milk fermentation broth prepared in the step 1; the method has the beneficial effects that the degradation efficiency on organic pollutants such as polycyclic aromatic hydrocarbon is remarkably enhanced, and a reliable material basis and theoretical support are provided for engineering application of an underground water bioremediation technology.
Owner:JILIN UNIVERSITY

High-energy cleaning type composite solid fuel additive and preparation method thereof

The present application relates to the technical field of fuel additive, in particular to a high-energy cleaning type composite solid fuel additive and a preparation method thereof. The additive comprises the following raw materials: myristic acid, stearic acid, a composite catalytic unit, modified soybean lecithin, tributyl borate, butylated hydroxyanisole and polyethylene glycol monostearate. The composite catalytic unit is prepared by coordination of diethyl phosphinic acid with manganese chloride, lanthanum chloride and cerium chloride; the modified soybean lecithin is obtained by ammonolysis and intramolecular lactonization and contains a five-membered cyclic phosphonate structure. During preparation, the components are dispersed by ultrasonic dispersion after being loaded on a melting carrier, and then solidified and formed. The additive realizes cleaning and repair integration through double-metal synergistic catalysis and combustion strengthening, and the composite carrier can controllably release and adapt to all working conditions. The product is soft and easy to discharge, has high economic efficiency and environmental compatibility, and is convenient to store and use.
Owner:GANZHOU GANSUBAO TECHNOLOGY CO LTD

Protein powder for promoting defecation

This invention relates to the field of food technology, and in particular to a protein powder that promotes bowel movements. To address the problems of some protein powders with added dietary fiber, such as poor compatibility between dietary fiber and protein, poor solubility, rough texture, and insignificant bowel improvement effects, ultimately leading to constipation, this invention comprises whey protein powder, casein powder, inulin, fructooligosaccharides, psyllium husk powder, soybean lecithin, and β-mannanase. This protein powder offers dual benefits of protein supplementation and intestinal health regulation. It efficiently supplements the protein needed by the human body, improves protein absorption and utilization, and is suitable for individuals with lactose intolerance and weak intestinal function. Simultaneously, through the synergistic effect of prebiotics, dietary fiber, and enzymes, it gently improves constipation symptoms, regulates intestinal flora balance, enhances intestinal peristalsis, and fundamentally protects intestinal health.
Owner:SHANGHAI JIAONA BIOMEDICAL TECHNOLOGY CO LTD

A nanoliposome containing sea cucumber ganglioside extract with neuroprotective activity and its preparation method

This invention provides a sea cucumber ganglioside extract nanoliposome with neuroprotective activity and its preparation method. The preparation steps are as follows: thawed frozen ready-to-eat sea cucumber, chopped, freeze-dried, pulverized, and sieved to obtain freeze-dried powder. The powder is then extracted using supercritical CO2 extraction and rotary evaporation to remove the solvent. This powder is then dissolved in anhydrous ethanol with soybean lecithin and β-sitosterol as the oil phase, mixed with PBS buffer, stirred, and hydrated to obtain a proemulsion. After centrifugation, the precipitate is resuspended and sonicated to obtain the product. This invention uses supercritical CO2 extraction, and the extract contains 59.70 μg / g of gangliosides, with glycosphingolipids accounting for 96.372% of sphingolipids, resulting in enrichment of the target components. Simultaneously, these nanoliposomes significantly delay Aβ1-42-induced paralysis. The 30 μg / mL group showed a 2.75-fold increase in motor ability and a 30% increase in reproductive function compared to the control group, and a 47% reduction in ROS levels. The neuroprotective effect is superior to that of the unencapsulated extract, providing a new approach for adjuvant intervention in neurodegenerative diseases such as Alzheimer's disease, and has broad application prospects in the functional food field.
Owner:SHANGHAI JIAOTONG UNIV +1

Chewing gum for promoting rapid recovery of cognitive fatigue as well as preparation method and application of chewing gum

PendingCN121243053ANervous disorderAerosol deliveryMannitolGum base
The invention discloses chewing gum for promoting rapid recovery of cognitive fatigue as well as a preparation method and application of the chewing gum. Comprising the following raw material components: linalyl acetate, gum base, D-mannitol, erythritol, purified water, caprylic / capric triglyceride, soya bean lecithin, Arabic gum, carnauba wax and potassium sorbate. The chewing gum is used after work fatigue or in a cognitive fatigue state at a high mental load post, and the specific process is as follows: a user puts one linalyl acetate chewing gum into the mouth in a room at the temperature of 20-30 DEG C, slowly chews the linalyl acetate chewing gum at the rhythm of 20-40 times per minute, discards the linalyl acetate chewing gum after chewing the linalyl acetate chewing gum for 4-6 minutes, and closes the eyes to have a rest for 15-20 minutes. The chewing gum disclosed by the invention can effectively promote rapid recovery of cognitive fatigue of high-mental-load working people and promote rapid recovery of fatigue of important post personnel such as unmanned aerial vehicle operation and radar monitoring, and the error rate and the accident rate are reduced.
Owner:ACADEMY OF MILITARY MEDICAL SCIENCES

Bacterial cellulose high-swelling-rate edible hydrogel sheet and preparation method thereof

The invention relates to a bacterial cellulose high-swelling-rate edible hydrogel sheet and a preparation method thereof. The bacterial cellulose high-swelling-rate edible hydrogel sheet comprises bacterial cellulose, kappa-carrageenan, glucomannan and microgel composite components. The bacterial cellulose, the kappa-carrageenan and the glucomannan are compounded to construct a three-dimensional network with high strength and high porosity, so that the hydrogel sheet can be quickly swelled in gastric juice, provides satiety and is finally disintegrated into a fiber suspension which is easy to discharge. By introducing a microgel composite component constructed by beta-cyclodextrin including epsilon-polylysine, kappa-carrageenan and soya bean lecithin, multiple functions of bacteriostasis, oxidation resistance, loading of fat-soluble active components and the like are further realized, and the taste and stability of the product are remarkably improved.
Owner:SUZHOU HVHA MEDICAL TECH DEV CO LTD

Artemia bait preparation and feeding method for cynoglossus semilaevis larva bait transfer period

The invention relates to the technical field of aquaculture, and discloses an artemia bait preparation and feeding method for cynoglossus semilaevis larvae in the bait transfer period, and the method comprises the following steps: constructing a basic artemia suspension; putting the artemia into an interface induction pretreatment solution containing soybean lecithin and taurine, and stirring at constant temperature under low-temperature and micro-inflation conditions, so that the artemia forms an induction adsorption layer and reaches pre-balance; then raising the temperature and adding microparticle compound feed in batches to carry out gradient competitive enhancement, so as to prepare enhanced artemia bait; and finally, carrying out collaborative feeding according to a preset strategy after cleaning. According to the method, interface induction and physiodynamic regulation are utilized, wrapping of the micropellet feed on the body surface of artemia and filling of the micropellet feed in the intestinal tract are achieved, the bait loading efficiency is remarkably improved, the problems that larvae and juveniles refer to feed and are insufficient in nutrition intake in the bait transfer period are effectively solved, the survival rate is increased, and water pollution is reduced.
Owner:TIANJIN FISHERIES RES INST (TIANJIN FISHERIES TECH EXTENSION STATION BOHAI SEA FISHERIES RES CENT OF CHINESE ACAD OF FISHERIES SCI)

Ergosterol peroxide composite slow-release agent as well as preparation method and application thereof

The invention discloses an ergosterol peroxide composite sustained-release agent as well as a preparation method and application thereof, and belongs to the technical field of medical antitumor drug preparations. The invention discloses a preparation method of an ergosterol peroxide composite sustained-release agent, which comprises the following steps: compounding ergosterol peroxide powder and soybean lecithin (Soybean lecithin, SPC, purity gradegt, 90%) through methanol, and sequentially carrying out the steps of normal hexane washing, reduced pressure rotary evaporation, filtration and ultrasonic treatment, so as to obtain the ergosterol peroxide composite sustained-release agent. Compared with the anti-tumor effect of pure ergosterol peroxide, the ergosterol peroxide has the characteristics of long circulation, low toxicity, strong targeting property, better treatment effect and the like.
Owner:XINJIANG UNIVERSITY

An extraction process of marine biological protein for sensitive skin whitening

This invention relates to the field of biological protein extraction technology, specifically disclosing an extraction process for marine biological proteins used for skin whitening in sensitive skin, comprising the following steps: S1, pretreatment; S2, acidic extraction; S3, enzymatic hydrolysis; S4, ultrafiltration and centrifugation. In the acidic extraction process, tannic acid, phytic acid, sulfonated soybean lecithin, and pepsin are added; in the enzymatic hydrolysis process, anthocyanins and magnesium gluconate are added. Through the synergistic effect of these processes, the purity and extraction rate of the marine biological protein are improved.
Owner:SHELL PARTY INNOVATIONS TECH SHENZHEN CO LTD

A pharmaceutical preparation for inhibiting esophageal squamous cell carcinoma metastasis and a preparation method thereof

PendingCN122297455AOil phaseOncology
This invention belongs to the field of pharmaceutical formulation technology, and particularly relates to a pharmaceutical formulation for inhibiting esophageal squamous cell carcinoma metastasis and its preparation method. The preparation method of the pharmaceutical formulation for inhibiting esophageal squamous cell carcinoma metastasis includes the following steps: S1. Dissolving paclitaxel, cyperene, and a glyceryl stearate derivative in an organic solvent to obtain an oil phase; S2. Dissolving soybean lecithin and Tween 80 in water to obtain an aqueous phase; S3. Mixing the oil phase and the aqueous phase at 70-75°C, stirring to emulsify, cooling to room temperature, and freeze-drying to obtain the final product. This invention loads paclitaxel and cyperene into a nanodelivery system, constructing a pharmaceutical formulation that can both enhance antitumor effects and achieve precise and efficient mucosal delivery via oral administration, which has significant clinical significance and application prospects.
Owner:LUOYANG CENT HOSPITAL

Oil-in-water type probiotic emulsion based on lactoferrin as well as preparation method and application of oil-in-water type probiotic emulsion

The invention discloses a preparation method of an oil-in-water type probiotic emulsion based on lactoferrin. The preparation method comprises the following steps: by taking a compound of lactoferrin and soybean lecithin as an emulsifier and medium chain triglyceride as an oil phase, dispersing probiotic freeze-dried powder in the oil phase, and carrying out high-speed shearing homogenization on a water phase and the oil phase, so as to obtain the oil-in-water type probiotic emulsion. The process for preparing the emulsion is simple and low in cost, the prepared emulsion can effectively embed the probiotics and has a good protection effect on the probiotics, and the gastrointestinal tolerance and environmental resistance of the probiotics in the emulsion can be improved. As a potential commercial product, the product shelf life can be prolonged, and the application range of probiotics and lactoferrin in the food field is expanded.
Owner:SOUTH CHINA UNIV OF TECH

Anti-inflammatory lipid phoyunbene C nanomaterial, preparation method and application

This invention discloses an anti-inflammatory lipid Phoyunbene C nanomaterial, its preparation method, and its applications. The nanomaterial mainly consists of Phoyunbene C nanodot cores, DSPE-PEG2000, soybean lecithin, and cholesterol. In the preparation process, Phoyunbene C is dissolved in phosphate buffer solution, heated, and stirred to obtain an aqueous phase. DSPE-PEG2000, soybean lecithin, and cholesterol are dissolved in ethanol, heated, stirred, and ultrasonically dispersed to obtain an organic phase. The organic and aqueous phase solutions are loaded separately into syringes, and a lipid Phoyunbene C nanodot solution is obtained through a biphase microfluidic mixing process. The preparation method of the lipid Phoyunbene C nanomaterial provided by this invention is simple and the preparation conditions are mild, achieving stronger anti-inflammatory effects both in vitro and in vivo, effectively improving osteoarthritis symptoms.
Owner:ZHEJIANG UNIV

Anti-coccidiosis preparation containing nicarbazin and preparation method of anti-coccidiosis preparation

The invention relates to the technical field of anticoccidial drugs, in particular to an anticoccidial preparation containing nicarbazin and a preparation method of the anticoccidial preparation. The anticoccidial preparation containing nicarbazin comprises the following raw materials in parts by mass: 3-7 parts of nicarbazin, 6-14 parts of monensin, 5-10 parts of mesoporous silica, 1-3 parts of chitosan, 1-2 parts of soybean lecithin, 0.1-0.5 part of carboxyl-terminated polyamidoamine, 1-2 parts of an emulsifier, 1-2 parts of a film-forming agent, 1-3 parts of a dispersant and 20-30 parts of vegetable oil. According to the present invention, the bioavailability is effectively improved, the problem of overhigh or overlow local drug concentration is overcome, the poultry can be prevented from being easily poisoned after ingestion, the treatment effect can be improved, the coccidiosis prevention and treatment effect is significant, the poultry growth is effectively promoted, the production cost is effectively reduced, and the batch production and the large-area promotion are easily achieved.
Owner:ZHEJIANG ESIGMA BIOTECH CO LTD

An ophthalmic composition comprising at least one nicotinic acetylcholine receptor modulator for topical administration to the eye to prevent or treat ocular inflammation.

PendingJP2026529127AOphthalmologyPhosphorylcholine
The present invention relates to ophthalmic compositions comprising at least one nicotinic acetylcholine receptor (nAChR) modulator, particularly varenicline, mecamillamine, and derivatives, and / or at least one substance of the endogenous Kennedy metabolic pathway, as well as salts and derivatives or pharmaceutically acceptable salts thereof, and choline-containing phospholipids, salts and derivatives thereof. Of these, choline, phosphocholine, CDP-choline (citicoline), phosphatidylcholine (e.g., lecithin with a phosphatidylcholine content of 80% by weight or more, e.g., soy lecithin), ethanolamine, phosphoethanolamine, CDP-ethanolamine, phosphatidylethanolamine, L-α-glycerylphosphorylcholine, phosphatidylcholine, and phosphatidylethanolamine are particularly preferred.
Owner:URSAPHARM ARZNEIMITTEL

Preparation method of composition for relieving tinnitus symptom

The invention provides a preparation method of a composition for relieving tinnitus symptoms, which comprises the following steps: stirring and mixing a ginkgo leaf extract, an organic solvent and soya bean lecithin to obtain a component primary solution; adding gamma-aminobutyric acid and alpha-lipoic acid into the component primary liquid, uniformly mixing, and concentrating and purifying to obtain a phospholipidized complex; uniformly mixing soybean lecithin, sitosterol and an organic solvent, concentrating, adding a buffer solution to prepare a liposome mixed solution, carrying out ultrasonic dispersion, adding the phospholipid complex, stirring to obtain a core-shell structure mixed solution, filtering, and freeze-drying to obtain core-shell structure powder; the composition for relieving the tinnitus symptom is obtained by adding the active components and the auxiliaries into the core-shell structure powder, granulating and filling into capsules, a stable core-shell structure is formed by the prepared phosphatidylated complex and lipidosome, the fat solubility and stability of the composition are improved, and the blood-brain barrier transmittance is also improved.
Owner:FOSUN HAPPY GOU (SHENZHEN) TECH CO LTD

Drug-loaded liposome constructed based on saikosaponin D as well as preparation method and application of drug-loaded liposome

The invention discloses a drug-loaded liposome constructed on the basis of saikoside D, and a preparation method and application of the drug-loaded liposome. The liposome comprises soybean lecithin, saikoside D, phosphatidic acid, an active drug and poloxamer 407. According to the invention, the saikosaponin D with antitumor activity is used for completely replacing cholesterol in the traditional liposome, so that the potential health risk of the cholesterol is avoided, the integration of medicines and auxiliary medicines is realized, and the saikosaponin D and entrapped medicines can generate a synergistic antitumor effect. The modification of the poloxamer 407 endows the liposome with the long circulation characteristic. The preparation method adopts a film dispersion-ultrasonic method, and is simple and convenient to operate. The prepared lipidosome is small in particle size, narrow in distribution and good in stability, the drug loading capacity is about 1.5-7.0%, the tumor cell inhibition effect superior to that of traditional cholesterol lipidosome and free drugs is shown in vitro, and the lipidosome has wide application prospects in the aspect of preparation of anti-tumor drugs.
Owner:YUNNAN UNIVERSITY OF CHINESE MEDICINE

Peelable, paintable composition for basecoats and architectural coatings

A peelable paint composition includes a release agent having a component selected from the group consisting of soy lecithin, a polysiloxane, silicone polyether, and combinations thereof. The peelable paint composition further includes a film-forming resin that includes a component selected from the group consisting of natural rubber, styrene-butadiene copolymer, polyvinyl butyral, a vinyl acetate-ethylene copolymer, vinyl acrylic copolymer that includes styrene, acrylic styrene copolymer, and combinations thereof. The peelable paint composition can further include a number of optional additives. Water makes up the balance of the paint composition.
Owner:BEHR PROCESS CORP

Curcumin-perilla seed oil composite liposome and preparation method thereof

The invention discloses a curcumin-perilla seed oil composite liposome and a preparation method thereof. The liposome is characterized in that soybean lecithin and beta-sitosterol are used as wall materials, curcumin and perilla seed oil are used as embedding materials, and Tween-80 is added as a dispersion stabilizer. The curcumin-perilla seed oil composite liposome prepared by the invention has the advantages of small particle size, high encapsulation efficiency and good stability, the preparation method is simple and controllable, the repeatability is good, efficient embedding and delayed release of curcumin and perilla seed oil are realized, and the oxidation resistance and nutrition of curcumin and perilla seed oil are fully exerted. The method can be applied to the field of food delivery and has a good market application prospect.
Owner:NORTHEAST AGRICULTURAL UNIVERSITY

Soybean lecithin-containing soil improvement fertilizer and preparation method thereof

The invention relates to the technical field of organic fertilizers, and discloses a soybean lecithin-containing soil improvement fertilizer and a preparation method thereof, the soybean lecithin-containing soil improvement fertilizer comprises a core layer and a coating layer; the core layer is a soil improvement functional substance, and the coating layer is an environment-responsive composite film; the soil improvement functional substance comprises an organic matrix, a compound microbial agent, a modified carrier, an amino acid synergist, a water and fertilizer retention agent and a solvent deionized water; the environment-responsive composite membrane is prepared from the following raw materials in parts by mass: soya bean lecithin, succinyl trehalose lipid, targeted response molecules and a solvent absolute ethyl alcohol. According to the invention, the soil structure can be improved, the degradation problems of soil hardening, organic matter decline and the like are relieved, and an efficient solution is provided for soil quality improvement and sustainable production.
Owner:GANYU JINZHONGHAN FERTILIZER CO LTD

A moisturizing eye composition and method of making and using same

ActiveCN120078801Bgood synergyImprove visual fatiguePalmitatesLiposome
The application belongs to the technical field of compositions, and provides a moisturizing eye composition, a preparation method and application thereof. The moisturizing eye composition provided by the application is combined by soybean lecithin, retinol palmitate liposome, lutein, oligomeric hyaluronic acid and ethylenediaminetetraacetic acid in a specific ratio, and good synergies can be achieved among the components, the effect of relieving asthenopia, protecting eyesight and maintaining normal vision is improved, and the effect of improving and relieving the symptoms of dry eyes and dry eyes caused by various reasons (such as fatigue, wearing contact lenses, using electronic products, overuse of eyes, etc.) is improved.
Owner:ZHUHAI YUANHANG BIOTECHNOLOGY CO LTD +1