68 results about "Capric triglycerides" patented technology

The invention relates to the technical field of repair compositions, and discloses a repair composition based on mussel mucin and application of the repair composition in skin barrier repair. The invention discloses a mussel mucoprotein-zinc composite microcapsule repair agent, which is prepared from the following components in parts by weight: mussel mucoprotein-zinc composite microcapsules, modified carboxymethyl chitosan, isolactone palmitate, a pH response type ceramide slow release system, dimeticone, cetostearyl alcohol, a calcium ion activating agent, an auxiliary repair factor, beheneth-25, caprylic / capric triglyceride, glyceryl monostearate, glyceryl distearate, pentanediol and citric acid. The preparation method comprises the following steps: adding ethanol, phenoxyethanol / ethylhexylglycerin, trehalose, beta-glucan and purified water; according to the whole technical scheme, through functional complementation and process optimization of all the components, synergistic interaction is achieved, the transpedermis water loss amount can be rapidly reduced, the water content of the skin cuticle is increased, the damaged skin barrier structure can be repaired from the source, and the resistance and stability of the skin are remarkably improved.

The invention relates to the field of cosmetics, in particular to skin moistening oil containing a water-soluble active matter and a preparation method of the skin moistening oil. The skin moistening oil of the water-soluble active matter is prepared from the following raw materials in parts by mass: 0.1-1 part of a phase A, 3-15 parts of a phase B and 80-100 parts of a phase C, wherein the phase A is a water-soluble component, and the water-soluble component comprises one or more of deionized water, VC ethyl ether and nicotinamide; the phase B is a solvent, and the solvent comprises one or more of ethyoxyl diethylene glycol, 1, 2-pentanediol, isopentanediol and isostearic acid; the phase C is skin moistening oil, and the skin moistening oil comprises caprylic / capric triglyceride. The skin moistening oil product provided by the invention has the advantages of clear and transparent appearance, good fluidity, excellent stability, no need of adding a surfactant or a solubilizer, mildness, no irritation, simple process, controllable cost, good practical value and good application prospect.

The invention discloses a composition containing achillea millefolium extract, which is prepared from the following ingredients in percentage by weight: 45 to 55 percent of glycerol, 4 to 6 percent of hydrogenated lecithin, 3 to 5 percent of caprylic / capric triglyceride, 1 to 3 percent of 1, 2-hexanediol, 0.8 to 1.2 percent of achillea millefolium extract, 0.4 to 0.6 percent of ergothioneine and the balance of water. Through precise compounding of the achillea millefolium extract and the ergothioneine, the dual effects of anti-inflammation and skin repair are achieved, flavonoid and organic acid components in the achillea millefolium extract can effectively inhibit release of inflammatory mediators such as IL-6 and TNF-alpha, and sensitive symptoms such as red and swollen and pruritus are relieved.

The invention provides blumea oil gel as well as a preparation method and application thereof, and relates to the technical field of daily chemicals. The blumea oil gel provided by the invention comprises the following components in percentage by mass: 45-65% of vegetable fat, 25-40% of polyol and 10-15% of an emulsifier, the vegetable fat comprises the following components in percentage by mass: 5-10% of folium artemisiae argyi essential oil, 30-40% of meadowfoam seed oil and 50-65% of caprylic / capric triglyceride. The meadowfoam seed oil and the caprylic / capric triglyceride are added into the vegetable fat component, so that volatilization of the folium artemisiae argyi essential oil can be reduced, and stabilization of effective components is facilitated; according to the blumea oil gel disclosed by the invention, the blumea oil gel is jointly formed by a proper amount of polyhydric alcohol, an emulsifier and vegetable fat containing the blumea oil, an oil gel system with a three-dimensional network structure can be formed, and a continuous oil phase in the system is fixed in a gel network, so that the stability of effective components is improved, and meanwhile, percutaneous absorption can be better promoted.

The invention discloses bath oil with stability and foamability and a preparation method thereof, and relates to the technical field of daily chemical products. The vegetable oil consists of peony seed oil, grape seed oil and sunflower seed oil in a mass ratio of 1: 2: 2. The bath oil is prepared from the following raw material components in parts by weight: 45 to 50 parts of vegetable oil, 18 to 22 parts of a surfactant, 16 to 18 parts of fatty alcohol-polyoxyethylene ether, 8 to 12 parts of caprylic / capric triglyceride, 1 to 3 parts of span 80, 0.1 to 0.5 part of an antioxidant, 1 to 3 parts of cocamidomethyl MEA and 0.1 to 2 parts of essence. On the basis of the compound vegetable oil, the optimal adaptive surfactant is screened out, then the compound antioxidant is introduced, and the bath oil which is long-acting, stable, high in foaming quality, clean, mild, nourishing and comfortable is effectively formed.

This application relates to the field of veterinary drug technology, and discloses a transdermal absorption-enhancing ointment and its preparation process. The ointment components include white petrolatum, anhydrous lanolin, caprylic / capric triglycerides, hydrophobic fumed silica, and a highly fluid active permeation-enhancing phase. The permeation-enhancing phase contains active drugs and soybean lecithin, which self-assemble to form an inverse micelle aggregate. Soybean lecithin cross-links with the silanol groups on the surface of silica to form an intermolecular hydrogen bond network, constructing a sterically hindered framework within a continuous lipid matrix to prevent the polar drug-loaded phase from permeating and separating upon heating. Simultaneously, the inverse micelle structure effectively improves the transdermal absorption rate of the drug. The preparation process controls the lipid crystallization kinetics through slow cooling under negative pressure and micro-shear dynamic rheology. This invention solves the problems of easy precipitation upon heating, low transdermal efficiency, and poor rheological properties in traditional ointments, resulting in a product with a stable physical structure and good pseudoplastic texture.

The application discloses a kind of enveloped virus inactivation preparation based on medium-chain triglyceride and application thereof, the present application relates to the technical field of biological medicine external preparation, including active ingredient and auxiliary material: the active ingredient includes: high-purity medium-chain triglyceride (MCT), preferably octanoic acid (C8) and capric acid (C10) triglyceride mixture, purity ≥99%; The auxiliary material includes: food-grade antioxidant, for preventing oxidation of preparation, the content of food-grade antioxidant is 0.01-0.05%w / w, with medium-chain triglyceride as active ingredient, through the physical and chemical synergistic effect, enveloped virus is efficiently killed, for treating stubborn skin mucosa infection diseases (such as stubborn flat warts, herpes labialis, genital herpes, etc.) caused by human papillomavirus (HPV), herpes simplex virus (HSV-1 / HSV-2), varicella-zoster virus and other enveloped viruses.

The invention discloses snowflake cream with pearly luster and a preparation process of the snowflake cream. The snowflake cream comprises the following raw material components: a phase A: water; butanediol; glycerol; methyl glucitol polyether-20; a polyacrylate cross-linked polymer-6; sodium hyaluronate; potassium hydroxide (90%); 4-hydroxyacetophenone; xanthan gum; phase B: caprylic / capric triglyceride; cetostearyl alcohol; stearic acid; a polydimethylsiloxane; squalane; simmondsia chinensis seed oil; mineral oil; and polyethylene glycol (PEG)-100 stearate. Glyceryl stearate; tocopheryl acetate; isononyl isononanoate; a phase C: 1, 2-hexanediol; carnosine; a centella asiatica extract; collagen; the snowflake cream has the advantages of uniform pearly luster texture and the advantages of traditional snowflake cream.

The present invention relates to antiperspirant and deodorant compositions for correction of body odour, and more particularly relates to antiperspirant and deodorant compositions for human hygiene. The disclosed anti-perspirant and deodorant composition comprises isobutane, propane, butane, cyclopentasiloxane, caprylic / capric triglyceride, stearalkonium hectorite, propylene carbonate, c12-15 alkyl benzoate, parfum, silver lactate, lactic acid, aqua, zea mays starch, menthyl ethylamido oxalate, argania spinosa kernel oil. Furthermore, the active antimicrobial silver ingredient is dermatologically tested and is capable of diminishing odor-causing bacteria in addition to prevention of irritation and itching.

The invention belongs to the field of pharmaceutical preparations, and provides an assembly material for indissolvable active transdermal mucosal drug delivery and a preparation method thereof. According to the invention, lipid cubic-phase nanoparticles composed of glyceryl monooleate, cholesterol, glycerol dioleate and caprylic / capric triglyceride are adopted, the design of DSPE-PEG2000 surface stability and ion coordinated regulation is combined, and high drug loading capacity and nanoscale particle size control are realized through a continuous process of melting, hydration, high-pressure homogenization and cubic-phase curing surface treatment. The preparation method solves the technical problems that high loading capacity of insoluble active ingredients and long-term colloidal stability are difficult to consider, cubic phase structure stability and surface charge controllability are contradictory in a tissue-friendly environment, and high drug loading capacity and devitrification prevention are difficult to couple under a low-temperature processing window, and has wide application value in the field of transdermal and mucosal local drug delivery.

The invention belongs to the technical field of cosmetics, and discloses a vitamin E emulsion and a preparation method thereof, the vitamin E emulsion comprises the following components by mass: 0.5-2 wt% of vitamin E and derivatives thereof, 10-20 wt% of a stabilizer, 10-20 wt% of a humectant, 3-6 wt% of an emulsifier, 0.3-1 wt% of a thickener, 0.5-1 wt% of a preservative, and the balance of water; wherein the vitamin E and the derivative thereof comprise at least one of vitamin E, tocopheryl acetate, tocopheryl linoleate, tocopheryl nicotinate and tocopheryl phosphate; the stabilizer comprises at least one of petrolatum, polydimethylsiloxane, hydrogenated polyisobutene, caprylic / capric triglyceride and butyrospermum parkii butter. Through the components, the antioxidant activity of vitamin E in the storage and skin retention process of the vitamin E milk can be effectively maintained.

This invention provides a liquid crystal biomimetic water-locking and oxygen-permeable skincare composition, its preparation method, and its application, belonging to the field of cosmetic technology. It comprises the following components by weight percentage: 20-40% glycerin, 5-10% hydrogenated lecithin, 5-10% phytosterols, 0.1-0.5% sodium stearoyl glutamate, 0.01-0.05% sodium methylstearoyl taurate, 0.1-1% ceramide NP, 1-10% caprylic / capric triglyceride, 1-10% squalane, 0.1-1% tocopheryl acetate, 0.01-0.3% sodium DNA, 0.001-0.1% fibronectin, 0.001-0.1% soluble collagen, and the balance being water. The liquid crystal biomimetic water-locking and oxygen-permeable skincare composition provided by this invention can better form a breathable protective film on the skin surface, reduce skin moisture loss, and help repair damaged skin barriers, thereby achieving the effect of water-locking and oxygen-permeable skincare.

The application discloses a high-permeability composite flavone composition and a preparation method and application thereof, and relates to the technical field of cosmetics. The application discloses a high-permeability composite flavone composition, wherein the composite flavone composition comprises flavones, lecithin, glycerol, propylene glycol, caprylic acid / capric acid triglyceride, tocopherol acetate and water; the flavones are total flavones of Sanguisorba officinalis and total flavones of Pericarpium Citri Reticulatae. In the process of extracting the flavones, ultrafine grinding and high-pressure microjet are combined, Sanguisorba officinalis and Pericarpium Citri Reticulatae are treated by using the ultrafine grinding, and Sanguisorba officinalis solution and Pericarpium Citri Reticulatae solution are treated by using the high-pressure microjet, so that the content of the flavones in the extract is increased.

The invention provides a bio-based efficient film-forming carrier for dissolving and stripping open and closed acnes, which is prepared from the following raw materials in percentage by weight: at least a phase A, a phase B and a phase C. The phase A at least comprises 0.1-1% of microcrystalline cellulose, 0.15-1% of cellulose gum, 3-8% of aureobasidium pullulans polysaccharide, 10-20% of alkaline blackhead exporting liquid, 2-5% of tromethamine and 30-80.25% of water; the phase B at least comprises 1-10% of caprylic / capric triglyceride and 0.5-5% of lauryl glucoside, and the phase C at least comprises 1-15% of cassava starch and 2-5% of 1, 2-pentanediol; the preparation method has the advantages that the reproducible bacterial nano cellulose is used as microcrystalline cellulose, so that a film forming system for dissolving and stripping open and closed acnes is milder and more effective, secondary injury to skin is avoided, and the film forming system is biodegradable, green and sustainable; the invention also provides a preparation method of the bio-based efficient film-forming carrier.

The invention discloses a preparation method of composite roasted peanut essence, which belongs to the technical field of essence, and comprises the following steps: preheating peanut oil and caprylic / capric triglyceride; the preparation method comprises the following steps: dissolving ethyl maltol, vanillin, methyl cyclopentenolone, 2, 3, 5-trimethylpyrazine and 2-acetylpyrazine; vanillin propylene glycol acetal, isovaleraldehyde propylene glycol acetal, triethyl citrate, delta-decalactone, delta-dodecalactone and 5-hydroxyethyl-4-methylthiazole are fused to obtain a mixture; dispersing the roasted peanut extract; 2, 3-dimethylpyrazine, 2-methoxyl-5-methylpyrazine and 4-methylthiazole are fused, and then the mixture is subjected to a reaction; the preparation method comprises the following steps: fusing cocaal, dimethyl sulfide, 2-ethyl-3, 5, 6-dimethylpyrazine, 2, 3, 5, 6-tetramethylpyrazine, 2-methylpyrazine, 2-acetylpyridine, 2-methoxy-3. 5. 6-isopropyl pyrazine, 2-methylthio-3-methylpyrazine, isovaleric acid, 1-octylene-3-alcohol, 5-methylfurfural and 3, 4-dimethyl-1, 2-cyclopentanedione; standing is performed; filtering is performed; the fragrance of the roasted peanuts is closer to that of the roasted peanuts which are just taken out of a furnace, and the natural flavor of the roasted peanut essence is increased.

The invention provides a composition with a whitening effect as well as a preparation method and application thereof. The composition comprises a mobile phase, an intermediate phase and an internal water phase, the intermediate phase comprises a castor oil / IPDI (isophorone diisocyanate) copolymer, caprylic acid / capric triglyceride and ascorbyl tetraisopalmitate; the inner water phase comprises a skin conditioner, a plant extract and water; the mobile phase is prepared from xanthan gum, polyvinyl alcohol, 1, 2-hexanediol and water. The composition disclosed by the invention is of a structure that the intermediate phase wraps the inner water phase and then is dispersed in the mobile phase, so that the stability of the active ingredients in the inner water phase is better, and the synergistic interaction of the active ingredients is more remarkable; after the composition is used for a skin care product, the composition has good compatibility with other skin care formulas, and the utilization rate of active ingredients in the composition can be brought into play to a greater extent.

The application discloses a long-acting makeup holding foundation liquid, which comprises water, titanium dioxide, hydrogenated polydecene, isododecane, isohexadecane, dimethicone, caprylic acid / capric acid triglyceride, dipropylene glycol, silica, polyglyceryl-2 dipolyhydroxystearate, synthetic fluorphlogopite, polymethylsilsesquioxane, a film forming agent, magnesium sulfate, cetyl PEG / PPG-10 / 1 dimethicone, lithium montmorillonite, triethoxysilane, ethanol, dimethicone / vinyl dimethicone crosspolymer, alumina, dimethiconol, collagen, natural extract, a colorant, a moisturizing agent and trace additives. The long-acting makeup holding foundation liquid has reliable water supplementing and moisturizing and oil control effects, can selectively absorb and control oil, has reliable skin friendliness, can reliably protect makeup of oily skin, and avoids the problem of makeup removal caused by facial oil secretion.

This invention discloses a universal method and composition for solving the pilling problem in cold-formulated cosmetics. Adding an effective amount of glyceryl oleate, citrate / caprylic / capric triglyceride to a cosmetic composition containing a pilling-prone cold-formulated emulsifier can significantly reduce or eliminate pilling. This substance has been discovered for the first time to have a novel anti-pilling application, effective against pilling caused by the emulsifier's own characteristics, high dosage, electrolyte interference, or the addition of large molecules, and is universally applicable to different types of cold-formulated emulsifier systems. This invention is particularly suitable for systems using electrolyte-rich natural plant extracts as the aqueous phase, fundamentally solving the pilling problem and providing a reliable solution for preparing high-feel, all-natural cold-formulated cosmetics.

The application provides a water-oil double-layer penetration-promoting cosmetic composition and a preparation method thereof, and relates to the cosmetic field. The raw materials of the water-oil double-layer penetration-promoting cosmetic composition include 5-30% of an oil phase and 70-95% of an aqueous phase according to a total mass of 100%. The raw materials of the aqueous phase include dipropylene glycol, glycerol glucoside and water. The raw materials of the oil phase include caprylic capric triglyceride and isosorbide dioctanoate. The isosorbide dioctanoate in the water-oil double-layer penetration-promoting cosmetic composition constructs a lipid microchannel, the dipropylene glycol enhances the hydration of the stratum corneum, and the glycerol glucoside activates AQP3 water channel protein. The three channels synergistically improve the penetration efficiency without damaging the integrity of the skin barrier. The penetration-promoting agent has strong broad-spectrum penetration-promoting ability for different polar functional ingredients, the penetration-promoting effect is stable, and the penetration-promoting agent can be stably distributed in the oil and water phases.

A skin care composition comprises growth-enhancing compounds which promote the development of a healthy skin microbiome and in particular, a carbon source selected from one or moreof glucose, fructose, saccharose, maltose, maltodextrin, pyruvic acid, pyruvate, lactic acid and lactate, and a nitrogen source selected from one or more of alanine, glycine, arginine and urea, and / or caprylic / capric triglycerides.

This invention discloses an oil-based nanostructured lipid carrier based on MLCT, its preparation method, and its application. The method includes mixing long-chain oil with decanoic acid triglyceride, adding immobilized lipase, vacuum drying, stirring, filtering, deacidification, and vacuum evaporation to obtain MLCT-structured lipids. Glyceryl monostearate is mixed with the MLCT-structured lipids and heated to form the oil phase. Trichosanthes kirilowii seed oil is mixed with ultrapure water and heated to form the aqueous phase. The aqueous and oil phases are then mixed, heated, ultrasonically broken up, and subjected to an ice bath to obtain the oil-based nanostructured lipid carrier. This invention replaces traditional small-molecule emulsifiers with natural oil bodies (OB) as emulsifiers, meeting consumer health needs while exhibiting excellent stability and safety; it also reduces the risk of chemically synthesized residues. Furthermore, the introduction of MLCT revolutionizes the digestibility of NLCs at the metabolic mechanism level. In vitro simulated digestion experiments show that the free fatty acid release rate is higher than 80%, providing a new solution for the development of functional food and drug delivery systems.

The invention relates to a ceramide nanoemulsion as well as a preparation method and application thereof, in particular to the ceramide nanoemulsion which comprises the following components: meadowfoam seed ceramide NP, ceramide AP and ceramide EOP, and further comprises an oil phase and a water phase, the oil phase is prepared from meadowfoam seed oil, tocopheryl acetate, caprylic / capric triglyceride, hexyldecanol and polyglycerol-10 myristate, the water phase is prepared from water, glycerol, hydrogenated lecithin, 1, 2-hexanediol and p-hydroxyacetophenone, and the ceramide nanoemulsion has multiple excellent skin care effects.

The invention belongs to the technical field of coating compositions, and relates to a thermal insulation clothing coating and a preparation method thereof. The invention provides a heat-insulating clothing coating, the heat-insulating clothing coating is formed by coating, drying and cooling a heat-insulating composite emulsion, the heat-insulating composite emulsion is formed by mixing and emulsifying a water phase and an oil phase, and the water phase is composed of a pretreated hollow silicon dioxide-aerogel composite dispersion liquid, propylene glycol and 1, 3-butanediol; the oil phase is prepared from a polydimethylsiloxane-polyether copolymer, isopropyl isostearate, caprylic / capric triglyceride, hydrogenated polyisobutene and carnauba wax. The thermal insulation clothing coating provided by the invention realizes synchronous improvement of thermal insulation performance and stability.

The invention discloses cactus essence oil with an anti-wrinkle effect and a preparation method of the cactus essence oil, and belongs to the technical field of skin care. Comprising the following raw materials: prickly pear seed oil, simmondsia chinensis seed oil, squalane, caprylic / capric triglyceride, bakuchiol, rosa damascena flower oil, sandalwood oil, frankincense oil, carrot seed oil, pelargonium graveolens oil, bisabolol, crithmum maritimum oil and tocopherol. According to the cactus essence oil with the anti-wrinkle effect and the preparation method of the cactus essence oil, the cactus seed oil is used as a core substrate, core components such as bakuchiol and crithmum maritimum oil are scientifically matched with soothing components such as bisabolol, and special preparation processes such as low-temperature premixing, step-by-step mixing, vacuum homogenization and light-shielding standing are combined, so that the cactus essence oil with the anti-wrinkle effect is obtained. The prepared cactus essence oil realizes multiple improvements of wrinkle resistance, stability maintenance, skin feeling and production practicability.

A method for preparing Pickering emulsion-type natural gel beads with sustained-release fragrance involves uniformly mixing gelatin, sodium alginate, and hydrophilic silica nanoparticles as the aqueous phase, and uniformly mixing fragrance and caprylic / capric triglycerides as the oil phase. The oil and aqueous phases are then mixed and homogenized to form an oil-in-water Pickering emulsion. Finally, the Pickering emulsion is pumped into a silicone tubing via a syringe pump and dripped into a mixed solution of calcium chloride and glutaraldehyde to form fragrance-loaded multi-compartment gel beads. This invention achieves sustained-release fragrance through the dual protection of the nanoparticle membrane and hydrogel of the Pickering emulsion, as well as the multiple compartments encapsulating the fragrance. This method is environmentally friendly, with a fragrance encapsulation rate exceeding 99%, and only 28.6% release after 42 days. It has broad application prospects in the daily chemical, food, and pharmaceutical industries.

The invention belongs to the technical field of refrigerating machine oil, and particularly relates to isocaprylic acid and isononanoic acid triglyceride and application thereof. The isocaprylic acid and isononanoic acid triglyceride comprises the following raw materials: isocaprylic acid, isononanoic acid, glycerol, an adsorbent and a catalyst, wherein the molar ratio of the isocaprylic acid to the isononanoic acid is 6: (9-14). By adjusting the ratio of isocaprylic acid to isononanoic acid in the raw materials of the isocaprylic-isononanoic triglyceride, the lubricating property of the isocaprylic-isononanoic triglyceride obtained by the reaction is improved, so that the lubricating property, glossiness and air permeability of the isocaprylic-isononanoic triglyceride are similar to or even slightly superior to those of caprylic-capric triglyceride when the isocaprylic-isononanoic triglyceride is used for cream cosmetics.

The invention relates to alcohol-free perfume and a preparation method thereof, and belongs to the technical field of daily chemicals. The perfume is composed of an essence composition and an alcohol-free solvent matrix. Wherein the essence composition is prepared from distilled chamomile essential oil and L-citronellol, the essence composition is prepared from lavender essential oil, sandalwood oil and iris absolute oil, the camphor of the lavender essential oil is removed through molecular distillation, the sandalwood oil and the iris absolute oil are subjected to antioxidant treatment, and the essence composition is prepared from cedarwood oil, benzoin resin and ambergris ether, the high-sensitization sesquiterpene of the cedarwood oil is removed through fractionation. The alcohol-free solvent matrix is formed by compounding caprylic / capric triglyceride, dipropylene glycol and ethylhexylglycerin. According to the invention, natural perfume is carefully selected and treated, a synergistic low-sensitivity essence framework is constructed, and the mild solvent is utilized, so that the stimulation of alcohol and common allergens is avoided, excellent fragrance quality and lasting fragrance are ensured, and meanwhile, the essence has extremely high safety and friendliness to sensitive skin.

The invention belongs to the field of analgesic drugs, and relates to a levobupivacaine liposome long-acting injection as well as a preparation process and application thereof. The injection comprises the following components: levobupivacaine, neutral phospholipid, charged phospholipid, cholesterol, tricaprylin, lysine, glucose and normal saline. Components are optimized, levobupivacaine and lipid components form a lipid phase in the preparation process, then the lipid phase is mixed with an internal water phase, and the stability of primary emulsion is better facilitated by combining the synergistic improvement of the components and the process; meanwhile, lysine and glucose are added into the external water phase, and the dosage is optimized, so that a stable charge system is formed, the generated liposome is more stable, and aggregation and flocculation of small balls are avoided; the encapsulation efficiency of the final product is 90% or above, D50 is 25-40 microns, the in-vivo half-life period is prolonged by 7 times compared with that of a common injection, MRT is prolonged by 6 times, the injection is stably released in SD rats, long-acting slow release of 48 h is achieved, and the injection has wide application prospects in the field of analgesic drugs.

This invention belongs to the field of pharmaceutical formulations and provides an assembly material and preparation method for transdermal and mucosal drug delivery of poorly soluble active ingredients. The invention utilizes lipid cubic phase nanoparticles composed of monooleate glycerol, cholesterol, dioleate glycerol, and caprylic / capric triglycerides. Combined with the surface stabilization and ion-synergistic regulation design of DSPE-PEG2000, a continuous process of melting-hydration-high pressure homogenization-cubic phase curing surface treatment is employed to achieve high drug loading and nanoscale particle size control. This invention solves the technical problems of balancing high loading of poorly soluble active ingredients with long-term colloidal stability, the contradiction between cubic phase structure stability and surface charge controllability in tissue-friendly environments, and the difficulty of achieving high drug loading and preventing crystallization coupling under low-temperature processing windows. It has broad application value in the fields of transdermal and mucosal local drug delivery.

The application discloses a composition with red fading effect and application thereof, and the composition comprises the following components in percentage by mass: 90-99% of a fat-soluble solvent, and 1-10% of a sargent pea extract; wherein the fat-soluble solvent is at least one of glycol, caprylic acid / capric acid triglyceride, sunflower seed oil, macadamia nut oil, white pool flower seed oil, silicone oil, squalane, ethylhexyl palmitate, diisostearyl malate, polyglyceryl-2 triisostearate, camelina sativa seed oil, octyldodecanol, and cocoyl caprylate / caprate. The sargent pea extract is mixed with the fat-soluble solvent, and the prepared composition has very significant red fading effect.