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672 results about "Octanoic Acids" patented technology

Duck plague yolk antibody freeze-dried powder and preparation method thereof

The invention relates to duck plague yolk antibody freeze-dried powder, which comprises the following components in percentage by weight: 87 to 90 percent of duck plague yolk antibody, 0.8 to 1.0 percent of octanoic acid, 0.2 to 0.3 percent of formaldehyde, 0.01 to 0.02 percent of thimerosal, 3 to 4 percent of glucose, 1 to 2 percent of sorbitol, 2 to 3 percent of glycine and 2 to 3 percent of mannitol. The freeze-dried powder has the advantages of long storage time, quick dissolution, high antibody valence and high bioactivity, and the purity of the antibody of the freeze-dried powder is higher than that of the conventional product in market. The invention also discloses a preparation method for the duck plague yolk antibody freeze-dried powder. The preparation method comprises the following steps of: separating strains to prepare vaccines, immunizing healthy ducks to obtain high-immunity eggs, performing sterilization, acidification, octanoic acid treatment, refining, extraction, purification, preparation, freeze drying and the like on the high-immunity eggs, and thus obtaining the duck plague high-immunity yolk antibody freeze-dried powder. According to the preparation method, yolk liquid is heated by using the temperature of pasteurization during acidification and water treatment, so that a sterilization effect is achieved, and the recovery rate of the antibody and the clarity of the solution during acidification can be improved at the same time; and the prepared yolk antibody has the advantages of high bioactivity, long storage time, retarded valence reducing speed and the like.
Owner:ZHENGZHOU HOUYI PHARMA

Duck virus hepatitis yolk antibody freeze-dried powder and preparation method thereof

The invention relates to a duck virus hepatitis yolk antibody freeze-dried powder which comprises the following components: 85-88% of duck virus hepatitis yolk antibody, 0.8-1.0% of octanoic acid, 0.01-0.02% of thimerosal, 0.2-0.3% of formaldehyde, 4-5% of glucose, 1-2% of sorbic alcohol, 2-3% of glycine and 2-3% of mannitol. The freeze-dried powder has the advantages of long preservation time, high dissolving speed, high antibody titer and excellent biological activity, and more importantly, the purity of the antibody of the product is higher than that of the existing product on the market. At the same time, the invention also discloses a preparation method of the duck virus hepatitis yolk antibody freeze-dried powder, comprising the following steps: voluntarily separating strains in a disease prevalence area to prepare a vaccine, immunizing healthy dusks to obtain hyper-immune eggs, ad performing disinfection, acidification, octanoic acid treatment, refining extraction and purification, preparation, freezing and the like on the hyper-immune eggs to obtain the duck virus hepatitis yolk antibody freeze-dried powder. According to the preparation method in the application, a yolk solution is heated at the temperature of pasteurization when the acidification water treatment is carried out, so that not only is the disinfection purpose fulfilled, but also the recovery rate of the antibody and the clarity of the solution in the acidification treatment are increased, the prepared yolk antibody has the advantages of high biological activity, long antibody preservation time, titer reduction, lowered speed and the like.
Owner:ZHENGZHOU HOUYI PHARMA

Method for synthesizing imidazoline intermediate and cationic derivative thereof

The invention relates to a method for synthesizing an imidazoline intermediate and a cationic derivative thereof. The method comprises the following process steps of: putting fatty acid, polyamine and water into a reaction kettle in a mole ratio of 1:1.1-2:1-5, heating to the temperature of between 100 and 180 DEG C to distill over the water added before and the water generated in the reaction, removing redundant polyamine and water under a pressure of between -0.04 and -0.1MPa and performing a reaction at a temperature of between 180 and 240 DEG C for 3 to 8 hours to synthesize the imidazoline intermediate; and reducing the temperature of the imidazoline intermediate to be below 80 DEG C, adding a solvent of which the mass is 30 to 100 percent of the imidazoline intermediate into the imidazoline intermediate, then adding 1 to 2mol of sulfate into the mixture and performing heat preservation reaction at the temperature of between 50 and 80 DEG C for 2 to 4 hours to synthesize cationic imidazoline. The fatty acid is oleic acid, linoleic acid, stearic acid, palmitic acid, lauric acid, coconut oil acid, capric acid and octanoic acid; the polyamine is ethylenediamine, diethylenetriamine, triethylene tetramine and tetraethylene pentamine; the solvent is isopropanol, absolute ethyl alcohol or 95 percent ethanol; and the sulfate is dithyl sulfate and dimethyl sulfate.
Owner:苗俊良
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