199 results about "Octanoic Acids" patented technology

The invention discloses alcohol dehydrogenase and a method for preparing (R)-6-hydroxy-8-chloro ethyl caprylate through catalysis of the alcohol dehydrogenase, and the alcohol dehydrogenase is selected from one or more of mutants of ADH1, ADH2, ADH3, ADH4, ADH5, ADH6, ADH7, ADH8, ADH9, ADH10 and ADH10; the amino acid sequences of the ADH1-ADH10 are as shown in SEQ ID NO. 1 to SEQ ID NO. 10. According to the invention, ethyl 6-carbonyl-8-chloro caprylate can be catalyzed to generate ethyl (R)-6-hydroxy-8-chloro caprylate or ethyl (S)-6-hydroxy-8-chloro caprylate, the reaction conversion rate of the mutant ADH10-A184L / N87F / A61L of ADH10 reaches 99%, and the e.e. Value of the R type is 99.2%.

The invention relates to the technical field of organic synthesis, and particularly discloses a synthesis method of bis-diglycerol polyacyl adipate-2, which comprises the following synthesis steps: S1, stirring and mixing isostearic acid, caprylic capric acid, stearic acid and 12-hydroxystearic acid to obtain total fatty acid; s2, stirring and mixing dipolyglycerol, adipic acid, total fatty acid and an organic tin catalyst, and starting to heat; s3, the initial reaction temperature is controlled to be 140-150 DEG C, the reaction vacuum degree is 0.04 MPa, the heating rate is controlled to be 2-10 DEG C / h in the reaction process, the temperature is increased to 190-210 DEG C, then the reaction vacuum degree is converted into 0.1 MPa, and the heat preservation reaction is conducted for 4-10 h; after the reaction is completed, sampling and measuring an acid value; and S4, after the acid value reaches the standard, carrying out heat preservation reaction for 2-5 hours under a high-vacuum condition, cooling, and filtering to obtain the product. The organic tin catalyst is used, the esterification period is shortened, the conversion rate is increased, and the production cost is reduced.

The invention provides a synthesis method of an absorption enhancer N-(8-[2-hydroxybenzoyl]-amino) sodium caprylate. The method comprises the following steps: dehydrating azelaic acid serving as a raw material to obtain anhydride; the preparation method comprises the following steps: taking 2-aminooctanoic acid as a raw material, reacting with ammonia water to obtain monoamide, concentrating, carrying out Hofmann degradation reaction to obtain an important intermediate 8-aminooctanoic acid, reacting with methyl salicylate in a solvent-free state, and purifying to obtain sodium N-(8-[2-hydroxybenzoyl]-amino) octanoate after the reaction is completed. According to the method, raw materials are easy to obtain, conditions are mild, purification is simple, a high-purity finished product can be obtained, and industrial production is facilitated.

The invention discloses an anti-skid resin type artificial stone material which comprises the following raw materials in parts by weight: 10 parts of composite resin, 55-70 parts of modified stone aggregate, 10-25 parts of needle-like wollastonite, 0.4-0.8 part of a curing agent, 0.05-0.2 part of a catalyst and 0.05-0.2 part of a light stabilizer, the composite resin comprises unsaturated polyester resin and an anti-skid filler in a mass ratio of 9: 1-7: 3, and the anti-skid resin type artificial stone material is prepared from the following raw materials in parts by weight: 10 parts of modified stone aggregate, 10-25 parts of needle-like wollastonite, 0.4-0.8 part of a curing agent, 0.05-0.2 part of a catalyst and 0.05-0.2 part of a light stabilizer. The anti-skid filler is one of ethylene glycol acrylate, glyceryl acrylate and acrylic acid modified sorbitol, the modified stone aggregate is formed by modifying stone aggregate through a stone aggregate modifier, and the catalyst is one of cobalt naphthenate, cobalt iso-octoate and manganese iso-octoate. The invention further discloses a preparation method of the anti-skid resin type artificial stone material, optimization balance of the anti-skid performance and other key performance of the artificial stone material is achieved, the application value of the artificial stone material in building decoration can be improved, and the safety and attractiveness of building space can be remarkably improved.

The invention discloses a silicone oil-free liquid foundation and a preparation method thereof, and relates to the technical field of cosmetics, the silicone oil-free liquid foundation comprises the following raw materials by weight: 2-6 parts of an emulsifier, 17-21 parts of grease, 10-14 parts of powder, 3-7 parts of a thickening suspending agent, 44-50 parts of water, 2-6 parts of polyol, 0.8-1.2 parts of an electrolyte, 1-3 parts of a film-forming agent, 0.8-1.2 parts of a preservative, and 2-4 parts of an active component, according to the scheme, a natural grease compounding system such as coconut oil alcohol-octoate / caprate, squalane and simmondsia chinensis seed oil is adopted, through molecular structure bionic design, a breathable moisturizing barrier is constructed while velvet-like smooth touch is provided, the problem that a traditional silicone oil product is sticky, greasy and stuffy is solved, and the requirements of consumers for silicone-oil-free and high-skin-friendliness base makeup are met.

The invention provides an inorganic silicon hybrid polyurethane primer as well as a preparation method and application thereof, and belongs to the technical field of primer. The primer provided by the invention is prepared from the following raw materials: polyester polyol, polyether polyol, trimethylolpropane, hexamethylene diisocyanate, 3-(phenylamino) propyltrimethoxysilane, ethyl acetate, xylene, an antioxidant, a light stabilizer, stannous octoate and a catalyst. An isocyanate-terminated polyurethane prepolymer is selected as a base material, a silane hybrid structure is introduced, a Si-O-Si network is formed after silane is hydrolyzed, the Si-O-Si network and Ca < 2 + > in concrete form a coordinate bond, and meanwhile, an isocyanate group reacts with water to generate a urea bond to reinforce anchoring. According to the primer disclosed by the invention, through a chemical-physical synergistic effect, the technical problem of bonding failure of a floating dust hardened layer is systematically solved, and an innovative solution is provided for long-acting sealing of a concrete joint.

The application discloses a method for preparing 6-hydroxy-8-chlorooctanoic acid ethyl ester by hydrogenation reduction of 6-carbonyl-8-chlorooctanoic acid ethyl ester. The carbonyl group of 6-carbonyl-8-chlorooctanoic acid ethyl ester is reduced to a hydroxyl group through a catalytic hydrogenation reduction reaction under high pressure, so that 6-hydroxy-8-chlorooctanoic acid ethyl ester is obtained. In the reaction process, strong acid, strong base and toxic substances are not involved, the catalyst used can be repeatedly used, the required equipment is not high, the process is simple, the obtained product has high purity and yield, and the method is favorable for large-scale production of enterprises, and provides a new preparation method which is simple and easy to realize, safe and stable, green and environmental protection, low in production cost and high in efficiency, and is suitable for the prior art and actual production.

The invention discloses weather-resistant and medium-resistant alkyd resin varnish and a preparation method thereof. The varnish is prepared from the following raw materials: modified alkyd resin, a composite drier, zirconium iso-octoate with the purity of 12%, an anti-skinning agent, 200 # solvent oil and xylene. The modified alkyd resin is prepared from the following raw materials: soya oil acid, pentaerythritol, benzoic acid, pyrrolidine-2-one-1-acetic acid, dimethylbenzene and a 200 # solvent. According to the invention, pyrrolidine-2-ketone-1-acetic acid is used as a binary acid component to partially or completely replace traditional phthalic anhydride, so that the reaction efficiency of alkyd resin synthesis can be improved, and the problems of yellowing, pulverization and poor water resistance of traditional alkyd resin can be solved; according to the varnish prepared by the invention, on the basis of maintaining the inherent gloss, flexibility and constructability of alkyd resin, the key properties such as weather resistance, water resistance and acid resistance are improved; the whole preparation process of the varnish continues to use mature alkyd resin production equipment and flow, and has good economical efficiency and industrial popularization prospects.

Methods improve cognitive functioning, for example, at least one of episodic memory, executive function, or language skills; supporting memory and / or recall; providing energy and / or ketones to the brain; and / or preventing and / or treating mild cognitive impairment (MCI) in an individual. A composition comprising medium chain triglycerides (MCTs) can be administered to the individual in a daily dosage providing from about 15 g to about 45 g MCTs. The MCTs can include from about 51 wt % to about 90 wt % of octanoic acid. The daily dose can be provided in at least two servings, for example, 2 or 3 servings. Each serving can provide about 15 g MCTs and can include octanoic acid and decanoic acid in a weight ratio of, for example, about 60:about 40. The individual can be 65 years or older and / or have mild cognitive impairment (MCI).

A lubricating fluid composition comprising i) a diester of polyethlene glycol esterified with a mixture of octanoic and deconoic acid where the polyethylene glycol may have 2-12 ethylene units and ii)

The invention belongs to the field of biological medicine, and particularly relates to an oral polypeptide composition for improving gastrointestinal tract absorption of polypeptide medicine. Specifically disclosed is an oral polypeptide composition comprising polypeptide molecules, medium-chain fatty acids and salts thereof, amino acids, and N-(8-(2-hydroxybenzoyl) amino) caprylic acid (NAC) and salts thereof. The oral polypeptide preparation disclosed by the invention can effectively improve the blood concentration of the polypeptide and improve the bioavailability of the oral polypeptide.

The invention discloses sodium caprylate and a preparation method and application thereof, the sodium caprylate is 8-(2-(2-hydroxyethoxy) benzamido) sodium caprylate, the 8-(2-hydroxybenzamido) sodium caprylate and 2-iodoethanol are subjected to a reaction in an organic solvent containing inorganic base to prepare the sodium caprylate, and the sodium caprylate can be used as a penetration enhancer in an oral administration system. And when the semeglutide oral soluble film is used for preparing the semeglutide oral soluble film, the semeglutide oral soluble film shows a very good in-vitro disintegration effect and a very good permeation promoting effect in animal experiments. The preparation method of the 8-(2-(2-hydroxyethoxy) benzamido) sodium caprylate is simple, does not involve expensive reactants, is convenient for post-treatment, and is beneficial to large-scale production.

Double-layer composite microcapsules suitable for asphalt surface layers that are both self-repairing, have high energy storage, and are resistant to ice and snow, as well as their preparation method and application, relate to a microcapsule preparation method and its application. The invention aims to address the technical problems of existing self-repairing microcapsules for asphalt pavements, such as poor core material release and self-healing effects, unstable shell wall materials, low thermal conductivity, easy leakage, and single functionality. The double-layer composite microcapsules of the present invention are composed, from the inside to the outside, of an inner phase-change microcapsule core, an inner phase-change microcapsule shell, an outer self-repairing microcapsule core, and an outer self-repairing microcapsule shell; the inner phase-change microcapsule core is prepared using n-octanoic acid and tetradecane; the inner phase-change microcapsule shell is prepared using carbon nanotubes and a double polymer; the outer self-repairing microcapsule core is prepared using bio-oil and carbon nanotubes; and the outer self-repairing microcapsule shell is prepared using carbon nanotubes and a double polymer. Compared to ordinary asphalt pavement, the healing index of the asphalt pavement surface layer prepared using the double-layer composite microcapsules is increased by 8.1% to 26.3%. It can be used in the highway field.

This invention discloses a compound, octanoic acid 4-methyl-5-thiazole ethyl mercaptan ester, with the specific chemical structure shown below: The aromatic compound is mainly used in food flavorings.

The invention discloses a PCI postoperative MACE risk prediction marker for an acute ST segment elevation type myocardial infarction patient, and belongs to the field of biological medicine. The application comprises application of a reagent for detecting the lipid metabolism marker in preparation of a kit for predicting the risk of main adverse cardiovascular events after the PCI operation of a patient suffering from the acute ST segment elevation type myocardial infarction, and the reagent for detecting the lipid metabolism marker comprises glycodeoxycholic acid, [(2R)-3-[(6Z, 9Z, 12Z)-octadeca-6, 9, 10-trimethyl-1, 3, 5-trimethyl-1, 3, 5-trimethyl-1, 3, 5-trimethyl-1, 3, 5-trimethyl-1, 3, 5-trimethyl-1, 3, 5-trimethyl-1, 3, 5-trimethyl-1, the detection reagent is selected from one or more of a detection reagent for N-((2S, 3R)-1, 3-dihydroxy octadecane-4-alkene-2-yl) acetamide, a detection reagent for 2-(2, 6, 7, 12-trienoyl) oxy-2-[(Z)-octadecane-9-enoyl] oxypropyl] 2-(trimethyl ammonium) ethyl phosphate, 8-hydroxy-8-(3-octyl oxirane-2-yl) octanoic acid and N-((2S, 3R)-1, 3-dihydroxy octadecane-4-alkene-2-yl) acetamide. The four lipid metabolism markers (C44H80NO8P, C18H34O4, C20H39NO3 and C26H43NO5) screened by the invention are used for the prediction efficiency of MACE prediction, the sensitivity of the four lipid metabolism markers reaches 0.889, the specificity of the four lipid metabolism markers is 0.894, the AUC of the four lipid metabolism markers is 0.921, and the four lipid metabolism markers have high sensitivity and high specificity.

Cosmetic preparation containing a) Glyceryl stearate citrate and b) 2-Propylheptyloctanoate.

The present invention provides a 13 Purification method of C octanoic acid and 13 C octanoic acid, relates to the technical field of chemical drugs, the 13 The purification method of C octanoic acid comprises the following steps: 13 The crude product of C octanoic acid was dissolved, pH value adjusted and crystallized in sequence, and the crystals were obtained. 13 The present invention uses the recrystallization method to treat the crude product, decolorize and remove impurities, and can effectively remove 13 The impurities introduced during the synthesis of C octanoic acid are removed to improve the purity of the purified product. The purification method is cheap and easy to obtain, the processing process is simple and easy, no special equipment is required, and industrial production can be achieved. 13 The production and application of C octanoic acid are of great significance.

The invention discloses p-toluenesulfonic acid 8-tert-butyl diphenyl silyloxy-7-methyl octyl ester as well as a synthesis method and application thereof, and relates to the technical field of biopesticides. The preparation method comprises the following steps: taking 8-bromocaprylic acid as an initial raw material, and firstly reacting with t-BuOK and 18-crown ether-6; then reacting with pivaloyl chloride to generate acid anhydride, and then carrying out acylation reaction with 4-benzyl oxazolidine-2-ketone; then carrying out diastereoselective methylation; then, NaBH4 reduction is carried out; carrying out hydroxyl protection; then carrying out hydroboration oxidation reaction; and then carrying out TsCl sulfonylation, so as to synthesize the p-toluenesulfonic acid-8-tert-butyl diphenyl silyloxy 7-methyl octyl ester. The optical purity of the (S)-p-toluenesulfonic acid 8-tert-butyl diphenyl silyloxy-7-methyl octyl ester synthesized in the invention reaches 98%, and the optical purity of the (R)-p-toluenesulfonic acid 8-tert-butyl diphenyl silyloxy-7-methyl octyl ester synthesized in the invention also reaches 98%.

The invention belongs to the field of novel functional polymer materials, and discloses a preparation method of a selenium-containing polymer material capable of fixing metal ions, and the preparation method comprises the following steps: S1, adding PTMEG into a round-bottom reaction flask filled with inert gas, and placing the round-bottom reaction flask in an oil bath pan for melting; s2, MDI, dimethylglyoxime, DSe and anhydrous N, N-dimethylacetamide are sequentially added and fully mixed; s3, stannous octoate and CuCl2 are added at the same time; s4, keeping the temperature of the oil bath pan and continuously reacting; s5, after the reaction is finished, a polymer is precipitated out, and secondary cleaning is conducted through methyl alcohol. The preparation method has the advantages that oximido is introduced into a polyurethane molecular structure to fix metal ions, meanwhile, selenium is introduced in a covalent fixation mode, and through double-site introduction of the metal ions and the selenium, the molecular structure of the polyurethane is greatly improved; the NO catalytic release rate of the material can be regulated and controlled, so that the biocompatibility and applicability of the polymer material in a blood environment are improved, and the application scene is further widened.

The invention discloses a carbon dioxide capturing agent based on organic amine as well as a preparation method and application thereof. The carbon dioxide capturing agent is prepared from the following raw materials in parts by weight: 60 to 80 parts of organic amine, 10 to 20 parts of octanoic acid, 3 to 7 parts of carbon powder, 5 to 10 parts of urea, 10 to 20 parts of polyethylene glycol 400, 1.8 to 4 parts of polyethylene glycol monooleate, 2 to 4.05 parts of choline chloride and 40 to 60 parts of solvent. The absorption performance and regeneration effect of the capture agent on carbon dioxide can be improved.

The invention provides an extraction process of a dunaliella salina fat-soluble anti-allergy active matter based on a caprylic acid-4-terpineol hydrophobic deep eutectic solvent, and belongs to the technical field of natural product extraction. The extraction process comprises the following steps: S1, adding dunaliella salina into a jasmine flower solution according to a ratio of 1: 20 (W / V), stirring and dispersing, and then centrifuging to obtain a wet substance; s2, octanoic acid, capric acid and 4-terpineol are mixed to prepare a hydrophobic deep eutectic solvent; s3, dispersing the wet substance in water to serve as algae liquid, adding a hydrophobic deep eutectic solvent, extracting for 30 minutes at the temperature of 80-100 DEG C, and centrifuging to take an upper oil phase; and S4, dissolving the oil phase in caprylic / capric triglyceride according to a ratio of 1-10% (W / W) to obtain the anti-allergy active matter. The extraction process is simple, the extracted active matter has good anti-allergy and anti-oxidation effects and safety, the fishy smell of dunaliella salina is effectively removed, and the active matter can be directly applied to cosmetics and other products.

The invention provides antimicrobial composition comprising (a) a first active ingredient, wherein in the first active ingredient is selected from the group consisting of petroleum jelly, EpiCeram® emulsion, and / or glycerin, and (b) a second active ingredient selected from the group consisting of 1-octanoyl-rac-glycerol, 1-decanoyl-rac-glycerol, glycerol monolaurate (GML), rac-glycerol 1-myrstate, glycerol monocaprate, glycerol monocaprylate, glycerol monomyristate, or reutericyclin, wherein the second active ingredient is present at a concentration of 10 μg / ml to 100 mg / ml in the composition. The compositions are useful as antimicrobial agents.

The utility model relates to reaction device processing technical field discloses a reaction device for synthesizing octanoic acid diethylamino ethanol ester citrate, including the reaction kettle, one end of reaction kettle is equipped with the heat dissipation shell, the inner wall fixed connection of heat dissipation shell has the motor, the output fixed connection of motor has the first bevel gear, one side fixed connection of first bevel gear has the worm, the outer wall screw thread connection of worm has the worm wheel, one side fixed connection of worm wheel has the connecting post, one side fixed connection of connecting post has the stirring piece, one side of first bevel gear is provided with the rotating assembly, and the rotating assembly includes the second bevel gear. In the utility model, the motor is started to drive the first bevel gear to rotate, the worm drives the worm wheel to rotate, the stirring piece rotates, and the material for synthesizing octanoic acid diethylamino ethanol ester citrate in the storage tank can be premixed.

The invention belongs to the technical field of microbial fermentation, and particularly relates to bacillus velezensis and application thereof in preparation of ethyl laurate, farnesyl acetate and octanoic acid. The invention provides a bacillus velezensis strain which is preserved in the China General Microbiological Culture Collection Center on October 13, 2025, and the preservation number is CGMCC No. 36155. The bacillus velezensis strain has the advantages that the bacillus velezensis strain is preserved in the China General Microbiological Culture Collection Center on October 13, 2025; the address of the preservation unit is Institute of Microbiology, Chinese Academy of Sciences, No.3, No.1 Yard, Beichen West Road, Chaoyang District, Beijing; ethyl laurate, farnesyl acetate and octanoic acid can be obtained by fermenting sugarcane juice with the fermentation broth. After subsequent extraction, the method can be used for industrial production.

The present invention relates to the field of chemical engineering, involving organotin, and specifically to a preparation method of a class of binuclear organotin compounds and their application in polyurethane flexible foams. First, a preparation method of binuclear organotin is provided. This method uses inexpensive reagents, has a simple formula, is easy to operate, and at the same time, is green, safe, highly efficient and environmentally friendly, and is suitable for industrial production. The organotin synthesized by this method contains two tin atoms in the molecule, and the polycyclic fragments in the molecule increase the rigidity and stability of the molecule, effectively enhancing its activity and catalytic efficiency. This organotin can be used in the production of polyurethane flexible foams, and the various indicators of the obtained polyurethane flexible foams are higher than those of the polyurethane flexible foams produced by ordinary stannous octoate.

The present application relates to the field of microbial technology, and particularly to a Pichia kudriavzevii (Pichia kudriavzevii) strain ZB448 and application thereof. Pichia kudriavzevi The Pichia kudriavzevii strain ZB448 provided by the present application has rich ester aroma, especially high content of phenylacetic acid ethyl ester, phenylacetic acid ethyl ester, ethyl acetate and isobutyl acetate, and significantly reduced content of ethyl octanoate; the aroma characteristics generated are strong fruit aroma and honey aroma and weak wine aroma, and the overall aroma is more pleasant and coordinated. The strain is used for fermentation of wheat protein seasoning juice, can effectively increase the content of ester aroma components in the product, weaken the adverse odor of bran koji, increase the content of umami amino acids, so that the product achieves the effect of rich ester aroma, rich aroma, and improved umami, and significantly improves the overall flavor and quality of the product.

A sunscreen composition, containing an effective amount of Methylene Blue and / or a hydrate and or a pharmaceutically-acceptable salt thereof; an effective amount of one or more UVA and / or UVB absorbing compounds, with the proviso that Oxybenzone and Octinoxate are excluded; and an excipient base.

This application relates to the field of fine chemical synthesis technology, and in particular to an efficient preparation process of octanoyl hydroxamic acid, which includes the following preparation steps: S1. Preparation of ethyl octanoate: Mix 90 - 110 parts by weight of octanoic acid and 35 - 40 parts by weight of ethanol, then add a solid acid catalyst, heat under reflux for 2.5 - 3 h, filter to obtain a precipitate and a filtrate, and distill the filtrate under reduced pressure to obtain ethyl octanoate; S2. Preparation of octanoyl hydroxamic acid: Add 0.4 - 0.6 parts by weight of sodium acetate and 0.2 - 0.4 parts by weight of sodium carbonate to water, stir until dissolved, add ethanol, stir, then add 24 - 32 parts by weight of hydroxylamine and the ethyl octanoate prepared in S1, and react to obtain octanoyl hydroxamic acid; it has the advantage of improving the reusability of the solid acid catalyst.

The application provides a high-efficiency rust-proof oil and a preparation method and application thereof. The rust-proof oil comprises, by weight, 60-80 parts of base oil, 1-4 parts of rust-proof agent, 15-25 parts of corrosion inhibitor, 1-3 parts of antioxidant, 0.5-2 parts of metal passivator, 1-3 parts of film forming agent, 0.3-0.45 parts of 1,4-diaminoanthraquinone and 0.25-0.75 parts of methyl octanoate. The preparation method comprises the following steps: heating and stirring No. 10 white oil and No. 32 white oil to obtain the base oil; adding the rust-proof agent, the corrosion inhibitor, the antioxidant, the metal passivator and the film forming agent into the base oil in sequence, secondly stirring, then adding the 1,4-diaminoanthraquinone and the methyl octanoate, thirdly stirring, fourthly stirring the obtained mixture, and adding triethanolamine dropwise until the pH value is 7.2-7.5 to obtain the rust-proof oil. The rust-proof oil is used in the field of metal rust prevention, and the corrosion resistance of the metal surface is greatly improved.

The combined use of biomarkers for cancer diagnosis, and in particular, the combined use of (a) 3-oxopropanoate and at least one of (b) a ketone body selected from beta-hydroxybutyrate, acetoacetate and combinations thereof, or (c) a medium chain fatty acid selected from octanoate, decanoate and combinations thereof, as a biomarker for the diagnosis of cancer. An in vitro method for diagnosing cancer in a subject based in the particular biomarker combination.