97 results about "ASCORBYL DIPALMITATE" patented technology

The invention discloses a pharmaceutical composition containing melogabalin besylate with good stability and a preparation method of the pharmaceutical composition. The pharmaceutical composition comprises an active component melogabalin besylate, one or more excipients, an adsorbent, a lubricant, a coating agent and an antioxidant, the antioxidant is a combination of L-ascorbyl palmitate and tartaric acid. The invention also provides a preparation method of the melogabalin besylate tablet, and the stability of the melogabalin besylate tablet prepared by the method is obviously improved.

The invention relates to the technical field of pet food antioxidants, in particular to a compound pet food antioxidant containing plant polyphenol compounds and a preparation method of the compound pet food antioxidant. 10 to 20 parts of a grape seed extract; 8 to 15 parts of a rosemary extract; 5 to 10 parts of L-ascorbyl palmitate; 5 to 10 parts of alpha-tocopheryl acetate; 3-8 parts of citric acid; 8 to 15 parts of soybean lecithin; 20 to 30 parts of medium chain triglyceride; eGCG (epigallocatechin gallate) in the green tea contains a plurality of o-dihydroxyl structures, the grape seed procyanidine has a unique C6-C3-C6 skeleton, and carnosic acid in the rosemary belongs to a diterpenoid compound. Due to the diversity of the structure, the compound can play a role in different types of free radicals and oxidation reactions, and a broad-spectrum anti-oxidation network is formed.

The invention relates to the technical field of composite hydrogel preparation, in particular to a nano composite hydrogel preparation process based on a microfluidic technology. The gel comprises the following components in parts by mass: 50-70 parts of a gel matrix, 5-9 parts of a nano enhancement system, 8-14 parts of a functional carrier, 3-6 parts of a dynamic response system, 4-7 parts of a hyaluronic acid-sulfhydrylated heparin compound and 0.5-1.5 parts of L-ascorbyl palmitate. Precise mixing and directional arrangement of all component materials on a micro-level are realized through a microfluidic technology, so that a nano reinforcing system and a functional carrier are uniformly distributed in a gel matrix, the synergistic effect of all the components is fully exerted, the mechanical property and the biological function of the gel are effectively improved, and the preparation method is suitable for industrial production. And quaternized chitosan nanofibers, a dynamic response system for responding to external environment change and a hyaluronic acid-sulfhydrylated heparin compound for promoting angiogenesis are introduced, so that the gel has the biological functions of resisting bacteria and promoting angiogenesis through a synergistic effect.

The invention relates to the technical field of functional antioxidants, in particular to a stability-enhanced antioxidant based on pterostilbene and a preparation method and application thereof. The pterostilbene tablet comprises the following components in percentage by weight: 10-30% of pterostilbene, 8-20% of Arabic gum, 5-15% of tocopheryl succinate, 1-5% of disodium ethylene diamine tetraacetate, 30-60% of beta-cyclodextrin, 2-8% of rosmarinic acid, 1-6% of chitosan quaternary ammonium salt, 0.5-3% of nano silicon dioxide and 2-7% of polyglycerol fatty acid ester. In the preparation process, beta-cyclodextrin and pterostilbene form an inclusion compound, the dispersity of nano silicon dioxide and chitosan quaternary ammonium salt is improved through hydrogen bonds, and tea polyphenol or ascorbyl palmitate can be added to enhance the synergistic effect. The antioxidant is high in stability, high in pterostilbene retention rate, uniform in dispersion, free of agglomeration, excellent in antioxidant activity, suitable for the fields of foods, cosmetics and medicines, simple in preparation process, low in consumption and suitable for industrial production.

The invention relates to the technical field of preparation of composite pigments, in particular to a preparation method of a high-temperature-resistant photolysis-resistant composite pigment and application of the high-temperature-resistant photolysis-resistant composite pigment in meat products. According to the technical scheme, the method comprises the following steps: preparing the following raw materials in parts by weight: pigment base materials: 5-18 parts of monascus red pigment, 4-12 parts of high-color-value capsanthin and 3-8 parts of beta-cyclodextrin embedded curcumin; the component A comprises the following components in parts by weight: 1-5 parts of ascorbyl palmitate, 2-8 parts of polyglycerol fatty acid ester, 0.5-3 parts of L-sodium ascorbate and 0.1-1.5 parts of nano titanium dioxide; and 1 to 4 parts of N-acetyl-L-cysteine. The ultra-high stability of the natural pigment under the conditions of high-temperature processing and strong light irradiation is realized, the processing tolerance and the final color development effect are balanced, the problem of uneven dyeing caused by early release of the traditional pigment is solved, the product quality and the application convenience are improved, and the unification of safety and efficacy is realized.

The invention discloses a reagent combination for protecting fragment integrity in DNA methylation detection, the reagent combination is used for protecting fragment integrity in DNA methylation detection sample transformation, and the reagent combination comprises tetrahydrofurfuryl alcohol, L-ascorbyl palmitate and ethylenediamine tetraacetic acid; wherein the volume concentration of the tetrahydrofurfuryl alcohol is 10%-80%; the molar concentration of the L-ascorbyl palmitate is 10 mM to 100 mM; the molar concentration of the ethylenediamine tetraacetic acid is 1 mM to 10 mM. The invention also provides a kit and a method for DNA conversion by using the kit. According to the reagent combination, damage of sulfite to DNA in the transformation process can be reduced, DNA degradation is prevented, a transformed fragment is longer than that of a traditional transformation method, the DNA recovery concentration and the library concentration are higher, follow-up detection is facilitated, and the sensitivity of a follow-up detection method is improved.

A complex consisting of lipoic acid or a salt thereof, a chelating agent such as a salt of ethylene diamine tetraacetic acid (EDTA) or analogous compounds and an ester of ascorbic acid with long-chain fatty acids, in particular ascorbyl palmitate inhibits the pigmentation of teeth induced by chlorhexidine and salts thereof. In addition to the depigmenting complex, the formulations of the invention, in the form of gels, mouthwashes, toothpastes or periodontal sprays, may contain other ingredients such as hyaluronic acid or hyaluronates, glycerophosphocholine, sweeteners, flavourings, buffering agents, viscosifying agents, mucoadhesive and filming agents, solvents, co-solvents, surfactants.

The invention relates to a composition containing anti-wrinkle lipidosome for cosmetic preparation and a preparation method of the composition, and belongs to the technical field of cosmetics. The invention discloses a composition containing anti-wrinkle lipidosome and a preparation method thereof. The composition comprises four plant extracts of purple coneflower, calendula officinalis, salvia officinalis and elderberry, and lipidosome consisting of lecithin, cholesterol, sphingomyelin and ascorbyl palmitate, and is supplemented with components such as a humectant and an emulsifier. According to the composition, through the synergistic effect of the plant extract and the lipidosome, the anti-wrinkle effect is enhanced, and the storage and illumination stability is improved; an extract structure is optimized by a compound fermentation process, and a liposome system is adapted; the components are safe and suitable for multiple skin types, the preparation process is compatible with industrial production, and the pain points that traditional anti-wrinkle products are poor in stability and insufficient in effect are solved.

The invention relates to the technical field of emulsification processes, in particular to a camellia oil emulsification production process. Comprising the following steps: step 1, mixing cassava starch with water to prepare starch milk; step 2, adding saccharifying enzyme and alpha-amylase into the starch milk, adding bacillus firmus for fermentation reaction, and after the reaction, inactivating the bacillus firmus, the saccharifying enzyme and the alpha-amylase to obtain a fermentation product; and step 3, mixing the fermentation product, camellia oil, sorbate monostearate, L-ascorbyl palmitate, cocoa butter, water and lecithin according to a mass ratio to obtain a mixture, heating the mixture to 40-45 DEG C, adjusting the pH value to 6-8, and circularly treating the mixture for 3-5 times under the pressure of 90-100 MPa through a high-pressure homogenizer to obtain a homogeneous emulsion. The prepared camellia oil emulsified product can still maintain a good gastric mucosa repairing effect after being stored for more than 24 months under a normal-temperature indoor illumination condition.

The invention belongs to the technical field of resveratrol synthesis, and particularly relates to a preparation method of resveratrol and application of resveratrol in meat preservation. The method comprises the following steps: taking 3, 5-dimethoxybenzoic acid as a raw material, and carrying out acylation reaction to obtain 3, 5-dimethoxybenzoyl chloride. Then reacting with p-acetoxystyrene to generate 3, 3 '-dihydroxy-3, 3'-dihydroxy-3 The preparation method comprises the following steps: taking 1, 5-dimethoxy-4 '-acetoxystilbene as a raw material, hydrolyzing and demethylating to obtain resveratrol, and preparing resveratrol lipid nanoparticle suspension by taking resveratrol, a ZIF-8 / chitosan compound, compound lipid, cholesterol, epsilon-polylysine, ascorbyl palmitate and phosphate buffer saline as raw materials. High load and controlled release of resveratrol are achieved, and the problems that resveratrol is poor in water solubility and prone to oxidation are solved.

This rotigotine-containing adhesive patch comprises a support layer and an adhesive layer, wherein the adhesive layer contains: at least one selected from the group consisting of rotigotine and pharmaceutically acceptable salts of rotigotine; a rubber-based adhesive base; and an antioxidant. The antioxidant includes propyl gallate, ascorbyl palmitate, and sodium pyrosulfite.

The application belongs to the technical field of biological medicine and medical cosmetology, and particularly relates to a kind of composition for mitochondrial protection type cosmetology and skin repair based on hydrogel and application thereof, the composition comprises a mitochondrial protection system and a synergistic active ingredient, the mitochondrial protection system comprises a hydrogel and a mitochondrial protection solution, the hydrogel comprises a synthetic polymer, and the mitochondrial protection solution comprises 200-300 mM mannitol, 0.2-5 mM ATP and 0-5% w / v trehalose; the synergistic active ingredient comprises a mixture of one or more of 0.01-0.1% ascorbyl palmitate, 0.1-1 mM glutathione and 0.5-2% nicotinamide. The composition is applied to microneedle repair, ice needle patch preparation and mask preparation and other aspects; through microneedle repair, ice needle patch or mask and other forms, effective delivery of mitochondria is realized, all-round care and repair are provided for the skin, and the delivery capacity is improved.

This invention discloses a soothing and repairing composition and its application, comprising the following raw materials: phytosterols, chamomile extract, hydrolyzed sodium hyaluronate, tocopherol, ceramide NP, triethanolamine, lactobacillus, macadamia seed oil, magnolia alcohol, matricaria flower extract, maltodextrin, lecithin, phosphatidylcholine, ascorbyl palmitate, inulin root juice, arginine / lysine polypeptide, squalane, jojoba seed oil, scutellaria baicalensis root extract, polygonum cuspidatum root extract, fructose, glycerin, p-hydroxyacetophenone, butylene glycol, acrylate / C10-30 alkanol acrylate crosspolymer, α-glucan oligosaccharide, 1,2-hexanediol, and water as the balance. Compared with the prior art, the soothing and repairing composition prepared by this invention has the effects of rapidly rebuilding the skin barrier, regulating skin immune function, improving skin microecology, synergistic effect, and rapid skin repair.

The invention discloses a method for improving the detection recovery rate of ascorbyl palmitate in a compound product, which comprises the following steps: taking a sample, adding BHT (butylated hydroxytoluene), then adding an isopropanol-n-hexane mixed solution containing 0.8-1.2% by volume of glacial acetic acid as an extraction solvent, then fully mixing, extracting, freezing, centrifuging, taking supernate, and collecting the supernate to obtain the ascorbyl palmitate. The chromatographic conditions are as follows: a C18 reversed-phase chromatographic column is adopted, a mobile phase A and a mobile phase B are used for gradient elution, the flow velocity of the mobile phase is 0.8-1.2 mL / min, the column temperature is 28-32 DEG C, and the maximum absorption wavelength of ascorbyl palmitate is taken as the detection wavelength. According to the method, the extraction efficiency is improved by optimizing a sample pretreatment process, and the problem that the liquid phase detection error of the substance in the compound product is generally higher than 10% is effectively solved in combination with improved high performance liquid chromatography separation conditions.

The invention provides starch sodium octenylsuccinate-free, protein-free and lactose-free fat powder as well as a preparation method and application thereof, and belongs to the technical field of foods. The fat powder provided by the invention comprises 25%-60% of glucose syrup (in terms of solid matter), 1%-20% of maltodextrin, 20%-50% of edible plant blend oil, 0.01%-3% of mono-and diglycerol fatty acid ester, 0.01%-3% of citric acid fatty glyceride, 0.1%-1% of sodium ascorbate, 0.005%-0.02% of ascorbyl palmitate and 0.01%-1% of potassium hydroxide. The fat powder provided by the invention is free of starch sodium octenylsuccinate, protein and lactose, good in solubility, good in dispersity and high in sinking speed. After being dissolved, the emulsion is milky white, has no (or few) small oil droplet floating, no precipitate and no floating object, and after standing, the solution is not layered.

The present invention provides an enhanced whitening cosmetic composition comprising (A) concentrated birch sap and (B) one or more substances selected from arbutin, tranexamic acid, niacinamide, glabridin, ascorbic acid, ascorbyl glucoside, ascorbyl dipalmitate and ascorbyl tetraisopalmitate, wherein the concentrated birch sap is concentrated at a multiple of about 1.05-6 times, preferably about 1.1-5 times, and more preferably about 1.2-4 times.

The invention provides an iron-free oxygen removal composition. The iron-free deoxidizing composition comprises ascorbyl palmitate, a natural antioxidant, activated carbon, adsorption silica gel, a 4A molecular sieve and water. The natural antioxidant comprises lycopene, ginger, orange and lemon powder. In the composition, the ratio of ascorbyl palmitate to lycopene powder to other components (activated carbon, adsorption silica gel with the water activity of 0.47-0.60 and a 4A molecular sieve) is maintained to be 3.2: 1.1: 1.4. The iron-free deoxidant composition has enhanced oxygen uptake capability, and can remove oxygen, moisture and peculiar smell in the package at the same time. The iron-free deoxidant composition is environment-friendly, and can prolong the shelf life of medicines, foods and nutritional health-care products.

The invention relates to eye drops containing umbilical cord mesenchymal stem cell exosomes. The eye drops are prepared from the following raw materials: sodium hyaluronate, an L-ascorbyl palmitate / hydroxypropyl-beta-cyclodextrin inclusion compound, panthenol, a solution containing the umbilical cord mesenchymal stem cell exosomes, water and normal saline, the concentration of the sodium hyaluronate is 0.2 to 0.6 mg / mL; the concentration of the L-ascorbyl palmitate / hydroxypropyl-beta-cyclodextrin inclusion compound ranges from 0.1 mg / mL to 0.4 mg / mL; the concentration of the panthenol is 0.2 to 1.0 mg / mL; the concentration of the umbilical cord mesenchymal stem cell exosome is 0.2 * 10 < 10 >-0.6 * 10 < 10 > parts / mL. The eye drops have good effects on treating xerophthalmia and repairing corneal epithelium injury.

The invention provides a thermo-sensitive hydrogel containing alpha-isoterpinene and a preparation method of the thermo-sensitive hydrogel, and the hydrogel comprises the following components: Te with the content of 0.1-5.0% (w / w); the temperature-sensitive matrix is composed of poloxamer 407 (15-25% w / w) and poloxamer 188 (2-10% w / w), and the mass ratio of the poloxamer 407 to the poloxamer 188 is (2.5-7.5): 1; the antioxidant system comprises ascorbyl palmitate (0.05-0.2% w / w), at least one of tocopherol, rosmarinic acid ester or pharmaceutically acceptable derivatives of the rosmarinic acid ester, and the balance of water. The traditional Chinese medicine composition is used for safely and effectively treating acnes. Belongs to the field of pharmaceutical preparations.

Present invention discloses a stable composition of lutein and zeaxanthin and preparation method thereof. The disclosed composition comprises of free lutein, zeaxanthin as active pharmaceutical ingredients, carrier i.e., combination of olive oil and canola oil, marker compound i.e., oleocanthal derived from extra virgin olive oil and excipients preferably selected from tocopherol, thyme oil and ascorbyl palmitate. The resulting composition is highly stable and possesses a longer shelf life of about 6-12 months. It can be encapsulated preferably in soft-gel capsule form or in in the form of tablet or any other oral formulation including jelly, chewing gum, energy bar or patch form.

The invention discloses a vancomycin hydrochloride solid capsule. The vancomycin hydrochloride solid capsule comprises a capsule shell and a content, the content comprises the following components in percentage by weight: 30%-40% of vancomycin hydrochloride, 5%-20% of Tween 80, 40%-65% of polyethylene glycol 6000 and 0.1%-1% of ascorbyl palmitate. The invention also discloses a preparation method of the vancomycin hydrochloride solid capsule, which comprises the following steps: (1) placing the Tween 80 and the polyethylene glycol 6000 in a container according to the formula ratio, and heating until the Tween 80 and the polyethylene glycol 6000 are molten; (2) adding the crushed vancomycin hydrochloride into molten polyethylene glycol, and uniformly stirring and mixing to obtain a molten mixed solution; and (3) filling a capsule shell with the molten mixed solution to obtain the capsule. The vancomycin hydrochloride capsule for oral administration can be prepared at a lower temperature through combined use of the Tween 80 and the ascorbic acid palmitate, and the problem that the vancomycin hydrochloride and a liquid preparation thereof are poor in stability is solved.

The invention belongs to the technical field of organic synthesis, and particularly relates to a method for synthesizing L-ascorbyl palmitate by an acyl chloride method. The method comprises the following steps: (1) adding palmitic acid into a mixed solvent, dropwise adding SOCl2, carrying out an acylating chlorination reaction, continuously adding L-ascorbic acid after the reaction is finished, and carrying out heating and heat preservation reaction to obtain a reaction product; (2) adding ethyl acetate and distilled water into the reaction product, putting into a separating funnel to obtain a water layer and an organic layer, extracting the water layer once by using ethyl acetate, and combining the organic layers obtained by two times; washing an organic layer with water for 3 times, then drying with anhydrous Na2SO4, and carrying out rotary evaporation to remove the organic solvent to obtain a crude product; and (3) purifying the crude product by using a silica gel chromatographic column, collecting eluent within 60-150 minutes, and performing rotary evaporation on the eluent to obtain the L-ascorbyl palmitate. The L-ascorbyl palmitate prepared by the method disclosed by the invention is high in yield and purity.

The application relates to the field of biological medicine, and discloses ascorbyl palmitate nanoliposomes capable of inducing tumor cell oncosis, a preparation method and application thereof. The nanoliposomes are constructed by inserting ascorbyl palmitate as a lipid component into a phospholipid bilayer, and are prepared by a film dispersion method from lecithin, cholesterol, pegylated phospholipid and ascorbyl palmitate. The average particle size of the nanoliposomes is 80-150 nm, the encapsulation rate is high, and the stability is good. The nanoliposomes can be administered through a tail vein, utilize the specific hydrolysis of matrix metalloproteinase MMP-2 which is highly expressed by tumor cells to hydrolyze ascorbyl palmitate, release palmitic acid and ascorbic acid, thereby inducing Caspase-independent oncosis of tumor cells, effectively overcoming apoptosis-related drug resistance, and reversing a tumor immunosuppressive microenvironment. The nanoliposomes avoid the cumulative toxicity of metal-type inducers, and provide a new safe and effective option for reversing chemotherapy resistance.

The invention relates to a toothpaste composition, in particular to a synergistic toothpaste composition containing lipidosome vitamin C and ascorbyl palmitate, which remarkably enhances the effects of improving gingival health and repairing oral cavity through the synergistic effect of lipidosome VC and L-AP. The toothpaste comprises the following components in percentage by mass: 45%-60% of a humectant, 10%-20% of a friction agent, 2%-3% of a cleaning agent, 0.5%-1.5% of an adhesive, 0.1%-0.2% of a sweetening agent, 0.1%-0.2% of a preservative, 0.5%-1.5% of L-ascorbyl palmitate, 1%-3% of liposome vitamin C, 0.3%-0.7% of vitamin E, 5%-10% of vitamin B, 2%-5% of zinc gluconate and the balance of water. Cell experiments and clinical data prove that the composition can remarkably promote gingival fibroblast proliferation, enhance I-type collagen expression and effectively improve the problems of gingival bleeding, swelling and pain, oral ulcer and the like.

The invention discloses a melogabalin besylate solid pharmaceutical composition, a preparation and a preparation method of the melogabalin besylate solid pharmaceutical composition. The solid pharmaceutical composition comprises melogabalin besylate, and further comprises L-tartaric acid, ascorbyl palmitate and a nonionic ester compound selected from at least one of hydrogenated castor oil and glyceryl behenate. According to the melogabalin besylate solid pharmaceutical composition, due to the adoption of the combination of the L-tartaric acid, the ascorbyl palmitate and at least one nonionic ester compound selected from the hydrogenated castor oil and the glyceryl behenate, through the synergistic effect of the L-tartaric acid, the ascorbyl palmitate and the nonionic ester compound, the stability obviously superior to that in the prior art can be achieved; and the solid preparation has excellent dissolution performance.

The invention provides a preparation method of a low-unpleasant-odor protein-containing emulsion, and relates to the technical field of food. The preparation method comprises the following steps: A, providing a water-phase buffer solution with the pH value of 6-7; b, dispersing protein, glutamine transaminase and ascorbyl palmitate in the water-phase buffer solution, and reacting under a stirring condition to obtain a protein dispersion solution; and C, adding other components into the protein dispersion liquid, dispersing, and inactivating glutamine transaminase to obtain the low-odor protein-containing emulsion. The preparation method can reduce pungent smell generated by sulfur-containing amino acid in the protein-containing emulsion.

The invention discloses a rhizoma polygonati anti-aging extract and a preparation method thereof. The method comprises the following steps: pre-treating raw materials by adopting a composite cleaning agent containing green tea polyphenol and a ginger extract; soaking with a sugar protecting agent containing fructo-oligosaccharide and L-ascorbyl palmitate; carrying out nine-steaming nine-drying treatment after gradient ultrasonic cleaning, and recovering polysaccharide in condensed water through spiral condensation, centrifugation and ceramic membrane filtration in the steaming process; the preparation method comprises the following steps: extracting with hot water, heating and concentrating, mixing the obtained extract with polysaccharide recovered from condensed water, compounding with a cistanche deserticola extract according to a ratio of 3: 2, mutually dissolving with a composite cosolvent, carrying out gelatin-Arabic gum microencapsulation, and finally granulating with a slow-release matrix. According to the invention, the problems of loss of pretreatment polysaccharide, waste of active ingredients of condensed water, poor stability of terminal products, asynchronous release and the like are solved through a full-chain technology, and the retention rate, the stability and the anti-aging synergistic effect of the active ingredients are remarkably improved.

The invention discloses essence containing mint and chrysanthellum indicum rose essential oil, the essence comprises a liquid part and an oil body part, the liquid part comprises water, propylene glycol, butanediol, glycerol, tremella fuciformis seed extract, triethanolamine, methylparaben, carbomer, xanthan gum and trace components; the oil body part is prepared from cyclomethicone, polydimethylsiloxane, vanillyl butyl ether and rose oil. The trace components comprise capryloyl hydroximic acid, glycerol caprylate, sodium polyacrylate, a chrysanthellum indicum extract, a mint extract, a portulaca oleracea flower / leaf / stem extract, a pelargonium graveolens extract, sodium hyaluronate, lactose, hydroxypropyl methyl cellulose, tocopheryl acetate, ascorbyl palmitate, CI 77007, an aloe barbadensis leaf extract and a radix sophorae flavescentis extract.

The invention discloses a method for rapidly detecting dichlorvos on site based on scattering turbidity, and belongs to the technical field of food and agricultural product safety detection. The method comprises the following steps: incubating dichlorvos with different concentrations with candida antarctica lipase, a phosphate buffer solution and L-ascorbyl palmitate, centrifugally incubating to obtain a reaction solution, taking a supernatant to react with a manganese dioxide nanosheet, measuring the turbidity of the reaction solution through a portable turbidimeter, and establishing a linear equation of the concentration and the turbidity of the dichlorvos; by measuring the turbidity of an unknown sample, the concentration of the dichlorvos can be calculated according to a linear equation. According to the method, invisible dichlorvos concentration signals are converted into measurable turbidity signals by utilizing the synergistic effect of enzyme inhibition reaction and turbidity change induction of the nano material, so that rapid and sensitive detection of dichlorvos is realized. The method is easy and convenient to operate, low in cost, high in detection speed, free of large instruments and especially suitable for on-site rapid screening of agricultural products.

The invention discloses a high-temperature-resistant milk-flavored essence fermentation composition and a preparation method thereof in the field of food biology. The high-temperature-resistant milk-flavored essence fermentation composition is prepared from the following raw materials: a milk grape graft, fresh peptide nucleotide, fermented whey liquid, a yeast extract, xylooligosaccharide, ascorbyl palmitate and a compound fermentation bacterium agent. Wherein the milk grape graft is prepared by fermenting a lactitol solution with geobacillus stearothermophilus and grafting beer yeast cell wall extract with alpha-1, 6-glucosidic bonds; the fresh peptide nucleotide is a small peptide-nucleotide compound formed by hydrolyzing concentrated whey protein through compound protease and fermenting hot spring streptomyces and lactobacillus plantarum; the fermented whey liquid is prepared through cow milk centrifugation, sterilization and three-strain gradient fermentation. The preparation method comprises the following steps: mixing the raw materials and mixing the compound fermentation inoculants under the protection of nitrogen. Through cooperation of the bifunctional modified compound and multiple strains, high temperature resistance, natural multi-flavor level and long-term stability are achieved, and the high-temperature-resistant milk powder is suitable for high-temperature processing scenes such as baking and sterilized milk.