50 results about "Secoisolariciresinol diglucoside" patented technology

The invention discloses a preparation of secoisolariciresinol diglucoside, including steps of: ethanol extracting flaxseed meal in a soxhlet extraction device, wherein concentrated solution is obtained by decompress concentrating the extract; edulcorating the extract by acid precipitation and centrifugation; obtaining crude product of secoisolariciresinol diglucoside by alkaline hydrolysis, regulating PH value of extract, decompress concentrating and drying subsequently; product of secoisolariciresinol diglucoside with high content of SDG is obtained by ethanol extracting the crude product. The inventive production process is simple, easy to industrialize, totally avoid using toxic organic solution, and avoid using separation medium such as silica gel, macroporous resin, gelatin. The invention is capable of keeping effective elements of polyphenol in raw material, so as to ensure good medicine efficacy of subsequent product, while in favor of security of subsequent usage. The product can be used to improve osteoporosis, metabolism disorder of blood lipid, obesity, depression caused by women's climacteric syndrome, and to prevent and treat diseases related to heart, prostate, colon and kidney.

The invention discloses a method for preparing secoisolariciresinol diglucoside (SDG), which comprises the following steps of: 1) crushing linseeds, extracting by using ethanol aqueous solution, and concentrating extracting solution to obtain concentrated solution; 2) adding alkaline aqueous solution into the concentrated solution, hydrolyzing at the temperature of between 50 and 80 DEG C for 30 to 40 minutes, cooling, regulating the pH to 3.5 to 4.5 by adding acid, standing for 30 to 40 minutes, centrifuging and collecting supernatant; and 3) adsorbing the supernatant through a macroporous resin column, washing the resin column until effluent liquid is not saline, eluting by using 25 to 50 volume percent ethanol aqueous solution, collecting the eluent, concentrating under reduced pressure and drying to prepare the SDG. The method is simple in process and is easily controlled, the extraction time and the hydrolysis time are greatly reduced, the production cycle is effectively shortened, the quality requirement of a product obtained by the method is met, the SDG content in the product is 30 to 50 percent, and the product yield is 3 to 5 percent.

This invention relates to methods and compositions for treating pathological lung conditions using whole-grain flaxseed or flaxseed lignans (isolated in form of the lignan precursor Secoisolariciresinol diglucoside (SDG) directly from whole-grain flaxseed or chemically synthesized directly into the mammalian, readily metabolizable forms, Enterodiol (ED) or Enterolactone (EL). Such pathological condition result from oxidative lung injury such as ischemia-reperfusion injury (related to lung transplantation), radiation fibrosis and cancer. Specifically, the invention is directed to the use of flaxseed lignans in the treatment of acute and chronic lung injury as well as cancer.

The invention relates to the method used to extract purification secoisolarciresinol di-glycoside from flax seed. It belongs to farm produce resource development and functionality health foods technique field. It includes the following steps: using flax seed as raw material; low temperature leaching degreasing by organic solvent; extracting by alcohol solution; adding alkali to hydrolyze; neutralizing and adjusting pH value; reducing pressure and condensing; micro-straining; and purifying. It has superiority in security, economical efficiency, preparation scale, and product purity. Its use is functionality food mixture or health foods.

The invention provides a production process of secoisolariciresinol diglucoside and the production process is characterized by comprising the following steps of: extracting secoisolariciresinol diglucoside from linseed oil residue, and performing extraction, concentration and acidity adjustment, loading on a column, drying and refining, so as to obtain secoisolariciresinol diglucoside with concentration being not less than 95%. The product is stable in properties and can be applied to the fields such as healthcare foods, medicines, healthcare products and drinks. According to the process, the linseed oil residue after oil is squeezed can be directly used, and the steps of extracting and then hydrolyzing, as well as concentrating and then adjusting pH value are avoided. The filtrate is directly load on the column without the need of sedimentation after concentration and pH value adjustment are performed; and the process is simple and practicable.

The invention belongs to the technical field of linseed oil production, and provides linseed oil rich in conjugated linoleic acid (CLA) so as to solve the problems that the shelf life of the linseed oil is shortened due to proneness to rancidity and the quality of the linseed oil is unstable caused by the fact that nutritional ingredients are damaged. The CLA and a composite antioxidant are added into the linseed oil, the adding quantity of the CLA accounts for 1%-4% of the total mass of the linseed oil; and the composite antioxidant comprises tea polyphenol, L-ascorbyl palmitate and vitamin E, the adding quantity of the tea polyphenol accounts for 0.01%-0.1% of the total mass of the linseed oil, the adding quantity of the L-ascorbyl palmitate accounts for 0.01%-0.1% of the total mass of the linseed oil, and the adding quantity of the vitamin E accounts for 0.005%-0.08% of the total mass of the linseed oil. According to the linseed oil rich in CLA, nutrient substances such as secoisolariciresinol diglucoside, phospholipid, vitamin and the like are more reserved, a packed product of the produced linseed oil is suitable for cold storage, the guarantee period under cold storage reaches 24 months, and the guarantee period at the ordinary temperature reaches 18 months. With addition of the CLA, the linseed oil is rich in both alpha-linolenic acid and the CLA, so that a functional unsaturated fatty acid is balanced and comprehensive.

The invention discloses a combined waste gas filtering tank and belongs to indoor ventilation equipment. The combined waste gas filtering tank comprises a tank body, wherein the tank body is provided with an air inlet and an air outlet; the box body is internally provided with drawer type separation layers for mounting filtering core materials; the drawer type separation layers are arranged between the air inlet and the air outlet; at least two drawer type separation layers are arranged; the filtering core materials at least comprise active carbon and an SDG (Secoisolariciresinol Diglucoside) adsorbent; and the active carbon and the SDG adsorbent cover the drawer type separation layers respectively to form a filtering section and an adsorption section in the tank body. The drawer type separation layers are arranged in the tank body so that a plurality of types of core materials for filtering or adsorbing can be mounted in the tank body, and various harmful components in waste gas can be conveniently treated, and furthermore, the filtering effect of waste gas is improved and the core materials can be conveniently replaced by adopting a drawer type structure; and a pressure difference of gas flows passing through the tank body is monitored in real time through a pressure difference alarm, so that the flow speed of the waste gas flowing through the tank body is in a controllable range and a condition that the flow speed is too rapid to affect the filtering effect of the core materials on the waste gas is avoided.

this invention relates to a method for preparing ring-opening secoisolariciresinol diglucoside from flaxseed, comprising: mix the clean flaxseed with 0.01-0.4M alcosol-alkaline solution at 1:2-8 weight ratio, extract for 2-3h at room temperature, filtrate and repeatedly extract the filtering deposit until the alcosol-alkaline solution becomes colorless, combine the filtrate; add acid into the filtrate to adjust the pH to 3-4 and then concentrate to the weight less than 1 / 3 weight of flaxseed raw material, add in water with 2-3 times volume of concentrated solution, repeatedly extract the above solution with weakly-polar solvent until colorless, evaporate the water phase to dryness; add the dry material into low-carbon alcohol, filtrate and evaporate the filtrate to dryness and then obtain the secoisolariciresinol diglucoside. This invention is characterized of simple process, low cost, and high purity.

The present invention provides an extracting and purifying method for improving the yield of SDG, and creates a SDG sequential extracting and purifying scheme based on the method. The technical route of the present invention is that operations of microbial fermentation, enzymatic degradation, and non-salt process are integrated in the SDG extracting and purifying technology process based on the prior art, thus greatly improving the efficiency of SDG extracting and purifying and lowering the manufacturing cost. The present invention also creates a SDG graded purifying process to prepare products, whose purities are respectively 8 to 10 percent, 20 to 40 percent, 50 to 60 percent, as well as 90 percent. The front two products need not column chromatographic separation, and the process operation is simple and safe, thus the present invention is economical and practical, and is suitable to the industrial production; the present invention can satisfy the needs of functional food ingredient and health food; later two products have mature technology, stable technology process, and high product purity, thus being able to satisfy the needs of pharmacological study and drug development.

A method of treating hypercholesterolemic atherosclerosis in a mammal exhibiting symptoms of the disease. The method comprises administering to the mammal an effective amount of a lignan complex derived from flax and containing about 34 to 38% by weight of secoisolariciresinol diglucoside. The invention also relates to compositions and uses of the complex suitable for the treatment of the disease and related conditions.

The invention discloses a method for extracting secoisolariciresinol diglucoside, and the method comprises the following steps of: (1) carrying out hydrolysis pretreatment on a flaxseed cake by cellulose, adding an ethanol solution into the treated flaxseed cake, treating in an ultrasonic-assisted way, stirring and carrying out extraction and centrifugation to obtain a secoisolariciresinol diglucoside crude product; (2) adjusting the pH value of the secoisolariciresinol diglucoside crude product to be 11.5-12.5, stirring and extracting at 50-55 DEG C, removing precipitation by centrifugation to obtain supernate, and adjusting the pH value to be 4.0-4.5; (3) enabling the supernate to be absorbed by macroporous resin chromatography at room temperature; and (4) eluting by using an ethanol solution to obtain an alcoholic solution containing secoisolariciresinol diglucoside, and carrying out vacuum freeze drying to obtain the secoisolariciresinol diglucoside finished product. The invention also discloses secoisolariciresinol diglucoside prepared by the method. The method combines multiple extraction methods, and is low in requirement for production equipment, high in extraction efficiency and obviously superior to the traditional solvent extraction method.

The invention relates to a method for simultaneously extracting and separating flaxseed gum and SDG from flaxseeds, comprising the following steps of: (1) adding water to the flaxseeds and then extracting for several times under stirring, filtering decoction and merging filtrates; (2) carrying out reduced pressure concentration on the obtained filtrate in the step (1) to obtain cream the relative density of which is 1.12-1.18; (3) adding alcohol to the cream so as to make the alcohol content of the cream reach 30-95 percent, evenly stirring, standing for 24-48h at the room temperature and filtering to obtain precipitates; (4) washing, filtering, drying and crushing the precipitates to obtain the flaxseed gum and meanwhile a cleaning solution and the filtrate; and (5) merging the obtained cleaning solution and the filtrate in the step (4), then recovering the alcohol in manner of the reduced pressure and concentrating into cream the relative density of which is 1.08-1.23; and drying and crushing the cream to obtain the SDG. The invention has simple process, can simultaneously extract the flaxseed gum and the SDG from the flaxseeds and is especially suitable for scale production.

The invention provides novel active printing dye for digital printing and a preparation method of the novel active printing dye. The preparation method particularly comprises the following steps: (1) mixing epoxy resin with aniline, stirring while heating, cooling, taking out the cool product, placing the cooled product in a solution containing chloroform and methanol, and carrying out vacuum drying to obtain an epoxy resin precursor; (2) dissolving vinyl sulfone sulfuric ester into an aqueous alkaline solution for complete dissolution, adding sodium nitrate, mixing uniformly, dripping the uniform mixture into an acetic acid solution, and stirring uniformly to obtain vinyl sulfone sulfuric ester diazo salt; (3) dissolving the epoxy resin precursor into a solvent, placing the solvent with dissolved epoxy resin precursor into an ice water bath, dripping the vinyl sulfone sulfuric ester diazo salt slowly, and stirring for a reaction to obtain modified vinyl sulfone-type reactive dye; (4) dissolving the modified vinyl sulfone-type reactive dye in water to form a pulp, adding urea, secoisolariciresinol diglucoside, and chitosan, then adding sodium carboxymethyl starch and residual water in sequence, and stirring sufficiently to obtain the uniform active printing dye used for digital printing.

The invention belongs to the technical field of linseed oil production, aims to solve the problems that the shelf life of the linseed oil is shortened due to easy rancidity and nutrients required for the growth and development of teenagers are lost in the refining process, and provides special linseed oil for the teenagers. Gamma-linolenic acid, vitamin A and an antioxidant compound are added into the linseed oil; the additive amount of the gamma-linolenic acid is 0.1%-0.6%; the additive amount of the vitamin A is 0.0001%-0.006%; and the antioxidant compound consists of tea polyphenol with the additive amount of 0.01%-0.1%, L-ascorbyl palmitate with the additive amount of 0.01%-0.1% and vitamin E with the additive amount of 0.005%-0.08%. The linseed oil is rich in alpha-linolenic acid, the gamma-linolenic acid and the vitamin A, comprehensive and balanced in nutrition and beneficial to the teenagers; more nutrients such as secoisolariciresinol diglucoside, phospholipid, vitamins and the like are reserved; the pressed linseed oil is free from rancidity within 18 months, so that the stable quality is guaranteed; and the cold storage shelf life reaches 24 months, and the shelf life at the normal temperature reaches 18 months.

The invention discloses an application of secoisolariciresinol diglucoside in preparation of a drug with resistance to eimeria tenella. Powder is prepared from the secoisolariciresinol diglucoside and acceptable auxiliary materials, is added to feed and is mixed uniformly, and chickens are fed according to the daily amount of feed; or water-soluble secoisolariciresinol diglucoside powder is prepared from the secoisolariciresinol diglucoside and dissolved in water, and the chickens are fed according to the daily drinking amount. Animal infection experiments prove that the ACI (anti-coccidial index) of the secoisolariciresinol diglucoside can be up to 165 or higher, and the secoisolariciresinol diglucoside has a better eimeria tenella resistant effect. Compared with a conventional anti-coccidial drug, namely, sulfachloropyrazin, the secoisolariciresinol diglucoside has a remarkable eimeria tenella resistant effect. According to the application of the secoisolariciresinol diglucoside, the problem of severe drug tolerance produced through adoption of the anti-coccidial drug in the current breeding industry can be effectively solved, the research and development speed of a new drug can be increased on the basis, and great benefits are provided for green and healthy development of the breeding industry.

The invention relates to processes for preparing (S,S)-secoisolariciresinol diglucoside and (R,R)-secoisolariciresinol diglucoside and compositions comprising the same.

The invention discloses a method for detecting useful and harmful ingredients in a flaxseed product. The method comprises the main steps of: preparing an interior label solution containing an interior label compound with a certain concentration; preparing standard solutions (with a series of concentrations) of an ingredient to be detected by using the interior label solution; analyzing in an LC-MS MRM mode; drawing a standard curve, wherein an X-axle is used for representing the concentration and a Y-axle is used for representing the ratio of an ingredient peak area to an interior label peak area; extracting a flaxseed sample by using the interior label solution and carrying out LC-MS MRM mode analysis on the extracted solution; and calculating the content of the useful ingredient (secoisolariciresinol diglucoside and SDG) and the harmful ingredient (flax cyanogenic glycosides and new flax cyanogenic glycosides) in the flaxseed product by using the standard curve or a regression equation. The detection method has the advantages of speediness, accuracy, good reproducibility, short time and the like, and is an important monitoring means for the quality control and the production condition of the flaxseed product.

The invention relates to a method for preparing secoisolariciresinol diglucoside and ferulic acid glucoside or ferulic acid glucoside ethyl ester. The method comprises the following steps: after the impurity removal and the degumming are performed to the flax seeds, the flax seeds are mixed with alcoholic-alkaline solution, extracted for 2-5 h at the temperature of 40-60 DEG C and filtered, then the filter residue is extracted until the alcoholic-alkaline solution is achromatous, and then the merging is performed; the filtrate is added with acid to be adjusted to be neutral and concentrated until the weight is one sixth-one second of that of the original filtrate, then the water with volume 2-5 times of that of the concentrated solution is added in, the extraction is carried out through the organic solvent until the organic phase is achromatous and then the aqueous phase is collected; the secoisolariciresinol diglucoside and the ferulic acid glucoside ethyl ester in the aqueous phase are fully absorbed through macroporous resin, then the water and the alcohol solution are respectively taken as the mobile phases for elution, then the 20v percent, the 30v percent and the 40v percent of alcohol eluent are collected, merged and distilled to dryness to obtain secoisolariciresinol diglucoside; and the 70v percent, the 80v percent and the 90v percent of alcohol eluent are collected, merged and distilled to dryness to obtain ferulic acid glucoside ethyl ester. The invention has the advantages of entire simple and feasible process, stable process and low cost; and the secoisolariciresinol diglucoside and the ferulic acid glucoside ethyl ester or the ferulic acid glucoside can be obtained at the same time and the product reaches the higher purity.

The invention relates to an anti-aging composition cationic nano-liposome as well as a preparation method and application thereof. The composition is characterized by being prepared from the followingcomponents in parts by mass: 7 to 20 parts of lipoid, 1 to 8 parts of astaxanthin, 5 to 10 parts of secoisolariciresinol, 1 to 3 parts of psoralen, 1 to 3 parts of hydroxyl pinacolone retinoic acid ester, 2 to 10 parts of cosolvent, 3 to 6 parts of cationic polymer, 15 to 30 parts of glycerol and 10 to 65 parts of deionized water, wherein the lipoid is composed of cationic lipoid and neutral lipoid; wherein the cationic polymer is a biosaccharide gum-polyethylene glycol (PEG) grafted copolymer. The liposome simultaneously loads astaxanthin, secoisolariciresinol diglucoside, psoralen phenol and hydroxyl pinacolone retinoic acid ester, has the advantages of good stability, small and uniform particle size, high load content and encapsulation efficiency, good skin feeling and good anti-agingeffect, and can be conveniently added into cosmetics for use.

The present invention relates to the field of food processing. Total-nutrient meal replacement powder containing secoisolariciresinol diglucoside comprises the following raw materials in parts by weight: secoisolariciresinol diglucoside, oat, quinoa, buckwheat, barley, black rice, millet, red beans, white kidney beans, chickpeas, mung beans, konjac gum, resistant dextrin, soy protein powder, soy peptides, wolfberry powder, flaxseed microcapsule powder, medium chain fatty acid powder, erythritol, stevioside, silicon dioxide, Vitamin A, Vitamin E, Vitamin B1, Vitamin B2, Vitamin B6, folic Acid,Vitamin C, niacin, pantothenic acid, calcium ascorbate, zinc gluconate, iron pyrophosphate and magnesium gluconate. The prepared total-nutrient meal replacement powder containing the secoisolariciresinol diglucoside has the effects of anti-tumor and increasing satiety.

This invention relates to methods and compositions for treating pathological lung conditions using whole-grain flaxseed or flaxseed lignans (isolated in form of the lignan precursor Secoisolariciresinol diglucoside (SDG) directly from whole-grain flaxseed or chemically synthesized directly into the mammalian, readily metabolizable forms, Enterodiol (ED) or Enterolactone (EL). Such pathological condition result from oxidative lung injury such as ischemia-reperfusion injury (related to lung transplantation), radiation fibrosis and cancer. Specifically, the invention is directed to the use of flaxseed lignans in the treatment of acute and chronic lung injury as well as cancer.

The invention provides compositions and methods for radio protection and chemo prevention using therapeutic and prophylactics methods of using (S,S)-SDG (R,R)- SDG, (S,R)-SDG (R,S)-SDG, SDG, SECO, EL, ED, analogs thereof, stereoisomers thereof and other related molecules. In one aspect, the invention relates to a method for protecting a biomolecule(such as genetic material like a nucleic acid, a protein or a lipid), a cell, or a tissue, from radiation damage in a subject in need thereof, the method comprising administering to said subject an effective amount of flaxseed, its bioactive ingredient, degradant or a metabolite thereof.

The invention discloses secoisolariciresinol diglucoside hydrogel based on soybean protein isolate and carrageenan and a preparation method of the secoisolariciresinol diglucoside hydrogel, and belongs to the technical field of food processing. The method comprises the following steps: (1) dissolving soybean protein isolate powder in water to obtain a hydrated protein solution, then heating to obtain a protein aggregate, and cooling for later use; (2) mixing a secoisolariciresinol diglucoside solution with the protein aggregate, and then adding carrageenan to obtain a pre-gel solution; and (4) adding gluconic acid-delta-lactone into the pre-gel solution to obtain the lignan hydrogel based on the soybean protein isolate and the carrageenan. The gel prepared by the method disclosed by the invention has good water binding capacity, viscoelasticity and capability of controlling the release of lignan.

The invention discloses an isopyrazam-containing antibacterial composition. The ratio of isopyrazam to secoisolariciresinol diglucoside in parts by weight is (1 to 1)-(20 to 1). By virtue of the compatibility of isopyrazam and secoisolariciresinol diglucoside in a specific proportion, the antibacterial composition has very good synergetic prevention and treatment effects to wheat powdery mildew, and particularly, the synergetic effects are very obvious when the ratio of parts by weight of isopyrazam to secoisolariciresinol diglucoside is (20 to 1)-(15 to 1).

The invention discloses a method for simultaneously producing five components in flaxseeds. The method comprises the following steps: (1) primarily extracting linseed gum and lignan from the flaxseeds; (2) performing cold pressing on the degummed linseeds by a hydraulic oil pressing machine to prepare linseed oil; (3) performing peel-kernel separation on the degummed and degreased flaxseeds; (4) crushing the flax peel subjected to peel-kernel separation, and extracting flax gum and secoisolariciresinol diglucoside again; (5) preparing flaxseed oil from the flaxseeds subjected to peel and kernel separation again; (6) extracting flax protein from the degreased flaxseed; (7) separating linseed cyclic peptide from the linseed oil prepared twice; and (8) extracting the flax cyclic peptide from the degreased and deproteinized flaxseed again. The steps are linked, the preliminary extraction or preparation of part of the components provides favorable conditions for the separation of the flax peel and kernel, the extraction or preparation rates of the components and other components are improved after the separation of the flax peel and kernel, the components supplement each other, the cost is low, the process is simple and easy to operate, the method is green and environment-friendly, and large-scale production can be realized; and the five components are produced at the same time, so that the additional value of the flaxseeds is greatly improved.

The invention provides a novel active printing dye for digital printing and a preparation method of the novel active printing dye. The preparation method comprises the specific following steps: (1) mixing epoxy resin with aniline to obtain a mixture, heating, stirring, cooling, taking out the mixture, adding the mixture into a chloroform-methanol solution, and carrying out vacuum drying, so as to obtain an epoxy resin precursor; (2) completely dissolving ethylene sulfone sulfate into an alkaline water solution, adding sodium nitrate, uniformly mixing, dropwise adding the solution into an acetic acid solution, uniformly stirring, so as to obtain ethylene sulfone sulfate diazonium salt; (3) dissolving the epoxy resin precursor into a solvent, adding the mixture into an ice-water bath, slowly and dropwise adding ethylene sulfone sulfate diazonium salt, and stirring to react, so as to obtain a modified ethylene sulfone active dye; and (4) dissolving the modified ethylene sulfone active dye into water, blending the ethylene sulfone active dye into slurry, adding urea, secoisolariciresinol diglucoside and chitosan, adding sodium carboxymethyl starch and residual water, and adequately and uniformly stirring, so as to obtain the active printing dye for the digital printing.