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392 results about "Gluconic acid" patented technology

Gluconic acid is an organic compound with molecular formula C₆H₁₂O₇ and condensed structural formula HOCH₂(CHOH)₄COOH. It is one of the 16 stereoisomers of 2,3,4,5,6-pentahydroxyhexanoic acid. In aqueous solution at neutral pH, gluconic acid forms the gluconate ion. The salts of gluconic acid are known as "gluconates". Gluconic acid, gluconate salts, and gluconate esters occur widely in nature because such species arise from the oxidation of glucose. Some drugs are injected in the form of gluconates.

Long-term fire retardant with corrosion inhibitors and methods for making and using same

A forest fire retardant composition contains a retardant compound that includes a potassium salt. The potassium salt may include a potassium salt of an organic acid, a potassium salt of an inorganic acid, or mixtures thereof. The organic acid may include formic acid, acetic acid, propanoic acid, butanoic acid, lactic acid, oxalic acid, malic acid, gluconic acid, tartaric acid, uric acid, malic acid, or citric acid. The inorganic acid may include sulfuric acid, phosphoric acid, carbonic acid, or hydrochloric acid. The composition may be in the form of a dry concentrate, a liquid concentrate, or a final diluted product. The final diluted product is effective in suppressing, retarding, and controlling forest fires while exhibiting corrosion resistance and low toxicity.
Owner:PERIMETER SOLUTIONS LP

Carbon ceramic resistor and preparation method thereof

The invention provides a carbon ceramic resistor and a preparation method thereof, and relates to the technical field of special material production of power systems and electrical equipment. The preparation method comprises the steps that carbon-containing electric conductor raw materials are mixed to obtain a first mixed raw material, and the carbon-containing electric conductor raw materials comprise, by mass, 15 parts of gluconic acid, 10 parts of aluminum oxide and 55 parts of deionized water; performing hydrothermal reaction on the first mixed raw material to obtain a carbon-containing conductor precursor; the carbon-containing conductor precursor is carbonized in a protective atmosphere, a carbon-containing conductor of a core-shell structure is obtained, and the carbon-containing conductor takes aluminum oxide as an inner core and takes a conductive carbon material formed by gluconic acid as a conductive outer shell; mixing the carbon-containing electric conductor with the core-shell structure with a carbon ceramic matrix raw material to obtain a resistor blank; and sintering the resistor blank to obtain the carbon ceramic resistor. The uniformity, the stability and the reliability of the carbon ceramic resistor are improved, so that the carbon ceramic resistor can better meet the application requirements of ultrahigh-voltage and extra-high-voltage alternating-current power transmission systems.
Owner:HUIZHOU POWER SUPPLY BUREAU OF GUANGDONG POWER GRID CO LTD

Preparation method of mesoporous Zn-ZSM-5 molecular sieve for preparing aromatic hydrocarbon from methanol

The invention discloses a preparation method of a mesoporous Zn-ZSM-5 molecular sieve for preparing aromatic hydrocarbon from methanol, and belongs to the technical field of synthesis of inorganic materials. Aiming at the problems that a conventional mesoporous Zn / ZSM-5 molecular sieve catalyst Zn blocks orifices, the mesoporous structure is disordered, the molecular sieve solid yield is low, a molecular sieve framework is seriously damaged and the like, the preparation method comprises the following steps: uniformly mixing zinc gluconate with an aluminum source, a silicon source and a template agent, putting the mixture into a closed reaction container, carrying out hydrothermal crystallization, and sequentially washing, drying and roasting to obtain the mesoporous Zn / ZSM-5 molecular sieve catalyst. The sodium type molecular sieve is obtained; the preparation method comprises the following steps: carrying out multiple ion exchange on a sodium type molecular sieve by using an ammonium chloride solution, and sequentially carrying out suction filtration, washing, drying and roasting to obtain the mesoporous Zn-ZSM-5 molecular sieve. According to the preparation method of the methanol-to-aromatic hydrocarbon Zn / ZSM-5 molecular sieve provided by the invention, the obtained molecular sieve is used in the methanol-to-aromatic hydrocarbon process, and has the characteristics of high carbon deposition resistance, high aromatic hydrocarbon selectivity, low Zn wastage rate and the like.
Owner:TAIYUAN INST OF TECH

Rare earth compound flocculant as well as preparation method and application thereof

The invention discloses a rare earth compound flocculant and a preparation method and application thereof.The rare earth compound flocculant is composed of a gluconic acid rare earth compound, a pyrithione rare earth compound and water, the content of the gluconic acid rare earth compound is 5-15 wt%, and the gluconic acid rare earth compound is prepared by reacting sodium gluconate with first chlorinated rare earth salt in water; the content of the pyrithione rare earth compound is 0.4-0.6 wt%, and the pyrithione rare earth compound is prepared by reacting sodium pyrithione with second chlorinated rare earth salt in water. According to the invention, rare earth ions have positive electricity, and show extremely strong coordination ability and high coordination number. Meanwhile, the surface of phaeodactylum tricornutum has electronegativity; therefore, when the rare earth ions are in contact with the phaeodactylum tricornutum, the rare earth ions and the phaeodactylum tricornutum can rapidly generate charge interaction, so that the phaeodactylum tricornutum is rapidly agglomerated and forms a lump, and then the lump
Owner:XIAMEN INST OF RARE EARTH MATERIALS

Leaching method and recycling method of metal in nickel cobalt lithium manganate positive plate

The invention provides a leaching method and a recycling method of metal in a nickel cobalt lithium manganate positive plate. The leaching method comprises the following steps: pre-treating a nickel cobalt lithium manganate positive plate disassembled from a waste battery to obtain positive powder; preparing a gluconic acid leaching agent containing gluconobacter oxydans, and electrolyzing the positive electrode powder at the voltage of 2.0-2.5 V by adopting a double-chamber electrochemical electrolytic tank to obtain a leaching solution containing Li < + >, Ni < 2 + >, Co < 2 + > and Mn < 2 + >. Positive electrode powder, a gluconic acid leaching agent and a ferrous sulfate aqueous solution are put into a cathode chamber of a double-chamber electrochemical electrolytic tank, and an inorganic alkali aqueous solution is contained in an anode chamber of the double-chamber electrochemical electrolytic tank; the leaching efficiency can be improved and the leaching rate is high through the effects of dissolution of gluconic acid, electrolysis for hydrogen release and auxiliary reduction of Fe < 2 + >.
Owner:DONGGUAN CHAM BATTERY TECH CO LTD

Gluconic acid pentazocine benzoate as well as preparation method and application thereof

The invention relates to gluconic acid pentazocine benzoate as shown in a formula (I), and a preparation method, a pharmaceutical preparation and medical application thereof. The invention provides application of the compound in preparation of medicines for treating moderate and severe acute and chronic pains, and the compound has the effects of high efficacy and low side effect. # imgabs0 #
Owner:ANHUI IPCKE PHARMACEUTICAL TECHNOLOGY DEVELOPMENT CO LTD

Method for detecting glucose based on cerium dioxide / gold nanocluster-Prussian blue nanoenzyme cascade catalysis

The invention discloses a method for detecting glucose on the basis of cascade catalysis of cerium dioxide / gold nano cluster-Prussian blue nano enzyme (AuNCs-CeO-HMPB). The material is prepared by compounding cerium dioxide (CeO) with similar glucose oxidase activity and hollow Prussian blue nanoparticles (AuNCs-HMPB) modified by gold nanoclusters with similar peroxidase activity through a hydrothermal assembly method. In the presence of glucose, CeO catalyzes oxidation of glucose to generate gluconic acid and H2O2, then AuNCs-HMPB synergistically catalyzes decomposition of newly generated H2O2 to generate high active oxygen species, further a colorless 3, 3 ', 5, 5'-tetramethyl benzidine (TMB) color developing agent is oxidized to generate obvious color change, and based on the cascade catalytic reaction, the enzyme-free glucose colorimetric sensor is successfully constructed. The sensor shows excellent detection performance on glucose under optimized conditions (pH = 4.0, 50 DEG C), the linear detection range is 10.00-90.00 [mu] mol / L, and the detection limit is 2.1 [mu] mol / L (S / N = 3).
Owner:GUILIN UNIV OF ELECTRONIC TECH

Composition containing mesenchymal stem cells and application of composition in preparation of product for resisting premature ovarian failure

The invention belongs to the technical field of medicines, and particularly relates to a composition containing mesenchymal stem cells and application of the composition in preparation of products for resisting premature ovarian failure. The invention relates to a composition containing mesenchymal stem cells. The umbilical cord mesenchymal stem cell gel is prepared from the following components in percentage by weight: 10 percent of umbilical cord mesenchymal stem cells, 4 to 6 percent of human serum albumin stock solution, 1 to 2 percent of ginkgo biloba extract, 1 to 3 percent of coix seed oil, 2 to 2.5 percent of flavonol glycoside, 1.1 to 1.3 percent of vitamin E, 0.4 to 0.8 percent of glutathione, 0.5 to 1.5 percent of sodium hyaluronate, 0.5 to 1.0 percent of phycocyanin, 1.2 to 1.8 percent of zinc gluconate, 0.5 to 0.8 percent of heparin calcium, 0.1 to 0.3 percent of pH regulator and the balance of normal saline. The composition disclosed by the invention can be used for preparing products for resisting premature ovarian failure and has a very good effect.
Owner:深圳惠善生物科技有限公司

Hair straightening compositions and methods of using thereof

PCT designated stage expiredWO2025073624A1Cosmetic preparationsHair cosmeticsHair straighteningFiber
A smoothing hair treatment composition, comprising: 6.0 to 10% by weight of a fiber active comprising a combination of citric acid and gluconic acid, based on the total weight of the smoothing hair composition; 10 to 20% by weight of a polyelectrolyte complex, based on the total weight of the smoothing hair composition; a surfactant selected from an anionic surfactant and a cationic surfactant; and a preservative; wherein the smoothing hair treatment composition is a leave-on treatment composition.
Owner:UNILEVER IP HLDG BV +2

Gluconolactone crystallization method

The invention relates to the technical field of crystallization and purification, in particular to a glucolactone crystallization method. The method comprises the following steps: sequentially carrying out four-stage cooling crystallization on a raw material containing gluconic acid, wherein each stage of cooling crystallization comprises gradient cooling independently carried out in four temperature zones. According to the method provided by the invention, glucolactone crystals with regular and uniform particles, narrow particle size distribution range and high purity can be obtained, the yield is obviously higher than that of a conventional one-time crystallization method, especially when centrifugal separation is carried out, the separation effect is good, the water content of the separated material is low, the addition of crystal washing water in the separation process is less, and the mother liquor generation amount is less; and the production cost is greatly reduced.
Owner:SHANDONG KAIXIANG BIOCHEMICAL CO LTD

Green method for extracting pear polyphenol

The invention relates to the technical field of polyphenol extraction, and provides a green pear polyphenol extraction method which comprises the following steps: performing steam explosion treatment on pear residue dry powder, and then infiltrating and activating by using an aqueous solution containing L-malic acid; adding betaine and D-gluconic acid into the first part of ultrapure water to prepare a deep eutectic solvent; mixing the eutectic solvent with a second part of ultrapure water to prepare a composite extracting agent; putting the infiltrated and activated raw materials and a composite extracting agent into an extraction device to obtain an extracting solution; carrying out solid-liquid separation on the extracting solution to obtain a clear solution; and adsorbing the clarified liquid through macroporous adsorption resin, then eluting with an ethanol water solution, collecting polyphenol-rich eluent, and carrying out spray drying to obtain the pear polyphenol extract. According to the technical scheme, the quality of an extracted product is improved, and polyphenol oxidation and thermal degradation are reduced; meanwhile, the product storage stability is improved, the phenomena of wall sticking and caking of powder are reduced, and the product yield and physical properties are guaranteed.
Owner:HEBEI RUILONG BIOTECHNOLOGY CO LTD

Capillary crystallization type waterproof agent, preparation method thereof and concrete material

PendingCN121554305APolyvinyl alcoholSilanes
The invention provides a capillary crystalline type waterproof agent and a preparation method thereof and a concrete material, the capillary crystalline type waterproof agent comprises a complexing agent, an active silicon component, modified silicon dioxide and a solvent, the complexing agent comprises polyvinyl alcohol grafted gluconic acid, the modified silicon dioxide comprises silane coupling agent grafted silicon dioxide, and the solvent is a solvent. The silane coupling agent contains an epoxy group. According to the invention, deep penetration, uniform distribution and long-term stable impermeability of the waterproof agent can be considered and optimized.
Owner:BEIJING ORIENTAL YUHONG WATERPROOF TECH CO LTD

Method for constructing antibacterial osteogenic coating on surface of titanium-based material and application of antibacterial osteogenic coating

The invention discloses a method for constructing an antibacterial osteogenic coating on the surface of a titanium-based material, which comprises the following steps: S1, after surface alkali modification of the titanium-based material, soaking the titanium-based material in a buffer solution containing polyethyleneimine and dopamine, taking out the titanium-based material, and airing the titanium-based material; s2, soaking the titanium-based material treated in the step S1 in a polyacrylic acid solution, then cleaning the titanium-based material with deionized water, soaking the titanium-based material in a chitosan quaternary ammonium salt solution, and then cleaning the titanium-based material with deionized water again; s3, the step S2 is repeated, the obtained titanium-based material is soaked in a polyacrylic acid solution and then cleaned with deionized water, the titanium-based material is aired at the room temperature after being cleaned, and a chitosan quaternary ammonium salt / polyacrylic acid coating is formed on the surface of the titanium-based material; and S4, the titanium-based material treated in the step S3 is soaked in a zinc gluconate solution, washed with deionized water after soaking and aired at the room temperature. The antibacterial rates of the coating on staphylococcus aureus and porphyromonas gingivalis are both greater than 95%, and the coating has excellent biocompatibility and osteogenic activity.
Owner:JIANGNAN UNIV

Hydrogel light-operated multi-mode synergistic treatment platform based on CuxS-MoS2 heterojunction for promoting healing of diabetes wound

The invention relates to a hydrogel light-operated multi-mode synergistic treatment platform based on a CuxS-MoS2 heterojunction for promoting wound healing of diabetes mellitus. And an interface induced electric field strategy is provided through density functional theory (DFT) calculation to optimize the charge migration behavior of the phototherapy agent. The multifunctional phototherapy system is constructed by taking CuxS-MoS2 with a built-in electric field as a core and PVA-CS hydrogel loaded with glucose oxidase (GOx) as a bracket. In a weakly acidic wound microenvironment, glucose at the wound is catalyzed by GOx to be converted into H2O2 and gluconic acid; meanwhile, the CuxS-MoS2 remarkably enhances the generation of reactive oxygen species (ROS) under illumination through peroxidase-like (POD) activity, photothermal effect (PTT) and heterojunction efficient carrier separation. After entering a proliferation period, the stent exerts catalase-like (CAT) activity to remove excessive ROS and release oxygen, and oxygen deficit and oxidative stress are relieved. In addition, the controllably released copper ions regulate and control the behavior of fibroblasts, promote healing and inhibit fibrosis. Experiments prove that the stent has excellent biocompatibility, effective antibacterial property and remarkable healing promoting effect in chronic wound repair of diabetes mellitus.
Owner:DALIAN UNIV OF TECH

Alditol oxidase and application thereof

ActiveUS20250115937A1BiofuelsMicroorganism based processesGluconic acidSaturated mutagenesis
An alditol oxidase and application thereof. The method uses D-glucose as a substrate to dock the alditol oxidase derived from Streptomyces coelicolor A3, and selects amino acid residues around an active center for saturation mutagenesis, and screens for alditol oxidase with D-glucose oxidizing activity by plate color development. An amino acid sequence of the alditol oxidase is shown in SEQ ID NO: 2 or SEQ ID NO: 4. The alditol oxidase has the activity of converting D-glucose to D-gluconic acid and D-glyceraldehyde to D-glyceric acid. By using the alditol oxidase, the conversion of D-glucose to pyruvic acid is realized by only three enzymes for the first time and does not depend on any coenzyme.
Owner:SOUTH CHINA UNIV OF TECH

Activated carbon electrode material for supercapacitor and preparation process of activated carbon electrode material

The invention relates to an activated carbon electrode material for a supercapacitor and a preparation process thereof, and belongs to the technical field of activated carbon electrode materials. The preparation process provided by the invention specifically comprises the following steps: mixing cane sugar, ammonium dihydrogen phosphate, deionized water and zinc gluconate, carrying out spray drying at 80 DEG C to obtain precursor powder with a loose structure, carbonizing, then carrying out pulse activation, water vapor reaming, cooling and post-treatment, mixing the obtained composite material with carbon nanofibers, a PTFE binder and absolute ethyl alcohol, and carrying out ball milling, so as to obtain the carbon nanofiber composite material. And coating the obtained slurry with an aluminum foil, drying, rolling, and carrying out hot press molding, thereby obtaining the product. According to the invention, cane sugar is used as a carbon source, zinc gluconate is introduced to assist in forming a honeycomb-shaped pore frame, and a honeycomb-shaped porous structure is formed along with further increase of carbonization temperature and multiple cyclic pulse activation and water vapor chambering processes, so that the ion transmission efficiency is improved, and the loss of a specific capacitance value under high current density is reduced; the capacitance performance of the material is improved.
Owner:福建韩研环保科技有限公司

Lactobacillus helveticus YM1922 for promoting brain development, improving concentration and nourishing nerves as well as metabolite, complex flora, metabolite and application of lactobacillus helveticus YM1922

The invention belongs to the technical field of microorganisms, and particularly relates to lactobacillus helveticus YM1922 for promoting brain development, improving concentration and nourishing nerves as well as a metabolite, a complex flora, a metabolite and application. The lactobacillus helveticus YM1922 is preserved in the China General Microbiological Culture Collection Center on September 10, 2024, and the preservation number of the lactobacillus helveticus YM1922 is CGMCC No. 31928. Fermentation metabolites of the strain can promote secretion of brain-derived neurotrophic factors, and thalli can inhibit production of intestinal tract D-gluconic acid in intestinal tracts. Therefore, the strain and the metabolite thereof have application potentials of promoting brain development, improving cognitive level, improving concentration and nourishing nerves, and can be prepared into products for playing corresponding roles.
Owner:HEBEI YUANMIN BIOTECHNOLOGY CO LTD

Silicon material cleaning agent as well as preparation method and application thereof

The invention belongs to the technical field of silicon material cleaning, and particularly relates to a silicon material cleaning agent and a preparation method and application thereof. The silicon material cleaning agent provided by the invention comprises the following components in parts by mass: 50-60 parts of water; 15 to 30 parts of an acidic etching solution; 10 to 20 parts of a first chelating agent; 10 to 20 parts of a second chelating agent; 0.5 to 5 parts of a surfactant; 5 to 15 parts of a builder; wherein the first chelating agent is selected from at least one of 1-hydroxyethylidene-1, 1-diphosphonic acid or ethylenediaminetetraacetic acid; the second chelating agent is selected from at least one of citric acid, gluconic acid, tartaric acid, malic acid, sodium citrate, sodium gluconate, potassium pyrophosphate and sodium pyrophosphate. The silicon material cleaning agent is used for silicon material cleaning, various metal ions can be cleaned at a time, the silicon material cleaning efficiency is improved, and the industrial cost is effectively reduced.
Owner:PUCHENG KUNPENG SEMICON MATERIAL CO LTD

Gamma-aminobutyric acid hydrolyzed egg yolk powder composite drink for promoting sleep and inhibiting bone age and preparation method of gamma-aminobutyric acid hydrolyzed egg yolk powder composite drink

PendingCN120514128AFood shapingBiotechnologyCarrot juice
The invention relates to the field of food materials, and particularly discloses a gamma-aminobutyric acid and hydrolyzed egg yolk powder composite beverage capable of promoting sleep and inhibiting bone age and a preparation method of the gamma-aminobutyric acid and hydrolyzed egg yolk powder composite beverage. A gamma-aminobutyric acid and hydrolyzed egg yolk powder composite beverage capable of promoting sleep and inhibiting bone age comprises the following raw materials in percentage: 3-5% of xylitol, 3-5% of fructo-oligosaccharide, 2-4% of gamma-aminobutyric acid, 3-9% of antioxidant composite concentrated juice, 0.16-1% of purple carrot juice beverage thick slurry, 0.1-0.19% of calcium aspartate, 0.02-0.05% of casein hydrolyzed peptide, 0.02-0.05% of hydrolyzed egg yolk powder, 0.02-0.05% of casein phosphopeptide and the balance of water. The formula comprises the following components in percentage by weight: 0.006 to 0.01 percent of zinc gluconate, 0.0005 to 0.00085 percent of zinc-rich edible yeast powder, 0.0005 to 0.00085 percent of tea theanine, 0.0005 to 0.00085 percent of N-acetylneuraminic acid, 0.0018 to 0.09 percent of a traditional Chinese medicine composition, 0.005 to 0.01 percent of L-calcium lactate, 0.0005 to 0.01 percent of collagen peptide, 0.1 to 0.3 percent of xanthan gum, 0.0005 to 0.00085 percent of melissa officinalis, 0.2 to 0.98 percent of a compound flavoring agent and the balance of purified water. Through the synergistic effect of all the components, the sleep quality is effectively improved, overactivity of bone cells is inhibited, and the bone age development is delayed.
Owner:DR DODO HEALTH TECH (HANGZHOU) CO LTD

High-efficiency mild unhairing cosmetic and preparation method thereof

The invention relates to the technical field of cosmetics, and discloses a high-efficiency mild depilation cosmetic and a preparation method thereof, and the raw materials of the depilation cosmetic comprise, by weight, 8-10% of bromelain; 10%-12% of a turmeric root extract; 9%-11% of a calendula extract; 6%-9% of an aloe extract; 4%-7% of a soybean extract; 7%-10% of calcium thioglycolate; 2%-5% of L-cysteine; 1%-3% of sodium bicarbonate; 3%-6% of green tea polyphenol; 2%-4% of a chamomile extract; 1%-3% of dipotassium glycyrrhizinate; 0.9%-2.3% of a peptide component; 0.5%-1% of rosmarinic acid; 1%-3% of vitamin E; 2%-4% of gluconic acid; 4%-5% of beewax; 5%-10% of an emulsifier; according to the invention, dipotassium glycyrrhizinate and the chamomile extract form a dual anti-allergy barrier, the physical protection effect of aloe polysaccharide is combined to reduce skin irritation, and the turmeric root extract and the peptide component prolong the hair follicle resting period and reduce the hair regeneration rate, so that the safer and more effective hair removal cosmetic is prepared.
Owner:GUANGZHOU YUNMEI COSMETICS CO LTD

Astragaloside synergistic composition as well as preparation method and application thereof

The invention discloses an astragaloside synergistic type composition as well as a preparation method and application of the astragaloside synergistic type composition. Comprising the following components: 8 to 16 parts of astragaloside, 20 to 40 parts of a honeysuckle flower extract, 10 to 20 parts of L-carnitine, 0.1 to 0.5 part of selenium yeast, 3 to 8 parts of diammonium glycyrrhizinate, 5 to 15 parts of taurine, 8 to 20 parts of a fructus forsythiae extract, 2 to 7 parts of vitamin E, 12 to 32 parts of hydroxypropyl-beta-cyclodextrin, 2 to 10.5 parts of maltodextrin, 1 to 7 parts of Arabic gum, 10 to 20 parts of lactose, 1 to 3 parts of zinc gluconate and 2 to 5 parts of magnesium stearate. 1-3 parts of vitamin C, 1-5 parts of xanthan gum and 1-3 parts of lecithin. The composition has a wide application prospect in preparation of veterinary drugs or veterinary food additives.
Owner:JIANGXI CHENGBIXIN BIOTECHNOLOGY CO LTD

Improved oral preparation based on traditional Chinese medicine prescription Yufengxiangshan and preparation method of oral preparation

The invention relates to the technical field of oral preparations, in particular to an improved oral preparation based on traditional Chinese medicine prescription Yufengxiang powder and a preparation method of the oral preparation. The preparation comprises traditional Yufengxiang powder components such as mung beans, radix angelicae, Chinese wolfberry fruits, licorice roots and poria cocos. And modern functional components such as turmeric, grape seeds, low-molecular-weight hyaluronic acid, L-ascorbic acid, zinc gluconate, a pumpkin seed extract, black pepper pigment and a rice essence extract. The preparation method comprises the following steps: respectively extracting the raw materials, drying into powder, mixing all active components according to the formula, controlling the moisture content of the powder, and filling into an enteric capsule shell. Through dosage form improvement and formula optimization, the bioavailability of active ingredients is remarkably improved, multiple synergistic effects of whitening, oxidation resistance, moisturizing, nerve soothing, alopecia improvement and the like are achieved, and the technical problems that traditional Yufeng western style powder is low in external use absorption rate and single in function are solved.
Owner:WUXI MEIYI BIOTECHNOLOGY CO LTD

A zinc gluconate ointment and a method for preparing the same

The present application relates to the field of external ointment preparation, and provides a zinc gluconate ointment and a preparation method thereof.The ointment comprises, by mass fraction: 0.3-2.0 parts of zinc gluconate, 0.05-1.5 parts of L-histidine, 0.05-1.0 parts of polysaccharide, and the balance of purified water, wherein the polysaccharide is chitosan oligosaccharide or hyaluronic acid oligomer.The zinc gluconate, L-histidine and polysaccharide are dispersed to form hydrogel microdroplets under the condition of pH 5.0-6.0, and are further dispersed in the continuous phase of the oil phase.By establishing a complex system in a weak acid environment and using a double constraint structure of microdroplet dispersion and oil phase, the free Zn 2+ The initial release rate is reduced, skin irritation caused by the initial release of traditional preparations is avoided, and a high 24-hour cumulative release amount is maintained.The ointment exhibits excellent physical stability and particle size uniformity during storage, avoids oil-water layering and crystallization, and has both sustained release and good use feeling.
Owner:HUBEI HUQUAN PHARMA IND

Promoter of gluconacetobacter xylinum source sequence and application of promoter in efficiently utilizing mannitol to synthesize bacterial cellulose

The invention belongs to the technical field of gene engineering, and discloses a promoter and application thereof in enhancing target gene expression and promoting mannitol metabolism to synthesize bacterial cellulose. The nucleotide sequence of the promoter P00300 is as shown in SEQ ID NO: 2. The promoter is obtained by site-directed mutagenesis of a wild type promoter P06915 of gluconacetobacter xylinum and screening. The promoter provided by the invention can be used for enhancing the expression of a target gene and producing a target compound. For example, the expression level of fk, mdh1 and mdh2 three-gene combination is remarkably improved, the recombinant strain can efficiently synthesize BC by using mannitol, and the yield reaches 6.1 g / L, is about 2.87 times of that of a wild strain, and is 1.27 times of that of a bla promoter in pBla. The result lays a foundation for further understanding mannitol metabolism of gluconacetobacter xylinum and for high-value conversion and utilization of marine carbon resource mannitol and BC synthesis.
Owner:TIANJIN UNIV OF SCI & TECH

Method for producing gluconamide derivative

To provide a novel method for producing a gluconamide derivative, a deoxy-sulfonyloxy gluconamide derivative, a deoxyhalogeno gluconic acid derivative, and a deoxymercapto gluconamide derivative.SOLUTION: In one aspect, a method for producing a gluconamide derivative includes contacting an amine compound with a gluconolactone protector to obtain a gluconamide derivative represented by the formula (3). In another aspect, a method for producing a deoxy-sulfonyloxy gluconamide derivative includes contacting a gluconamide derivative represented by the formula (3) with a sulfonylation agent to obtain a deoxy-sulfonyloxy gluconamide derivative.SELECTED DRAWING: None
Owner:TOKUYAMA CORP

Preparation method of glucolactone crystal with controllable product granularity

The invention relates to the technical field of chemical preparation, and discloses a preparation method of a glucolactone crystal with controllable product granularity, which comprises the following steps: carrying out ultrasonic induced nucleation on a gluconic acid concentrated solution to generate a seed crystal, then cooling to 40-50 DEG C at a cooling rate of 0.5-1.5 DEG C / h, stirring by adopting a Taylor flow stirrer while cooling, and then cooling to 40-50 DEG C at a cooling rate of 0.5-1.5 DEG C / h to obtain the glucolactone crystal with controllable product granularity. A 45-degree four-blade axial Taylor flow stirring paddle is assembled below the Taylor flow stirrer, the rotating speed is 200-400 rpm, the ratio of the diameter of the Taylor flow stirring paddle to the inner diameter of the crystallizer is 0.4-0.8, after the cooling procedure is completed, solid-liquid separation is conducted, crystals are collected, and a glucolactone crystal product is obtained after drying treatment. The number of fine grains is controlled by changing the ratio of the diameter of the Taylor flow stirring paddle to the inner diameter of the crystallizer and the stirring speed, glucolactone crystal products with different granularities are obtained, the process is stable, the granularity of the glucolactone crystals can be effectively controlled, and the granularity of the crystal products can be finely adjusted according to actual product requirements.
Owner:TIANJIN UNIV OF SCI & TECH

Biobased compounds for polymer production

A polymeric material comprising a base monomer and a multifunctional biobased molecule wherein the multifunctional biobased molecule is a glucose derivative. A polymeric material comprising a base polymer and a polymeric additive comprising glucaric acid, glucodialdose, gluconic acid, erythorbic acid, 2-ketoglucose, lactic acid, adipic acid, sorbitol, glycerol, mannitol, lactones thereof, salts thereof, or combinations thereof wherein the additive when introduced to a base polymer forms a modified polymer wherein the modified polymer has a tensile strength that is increased by from about 10% to about 100% wherein compared to the base polymer.
Owner:SOLUGEN INC