345 results about "Gluconic acid" patented technology

The invention provides a carbon ceramic resistor and a preparation method thereof, and relates to the technical field of special material production of power systems and electrical equipment. The preparation method comprises the steps that carbon-containing electric conductor raw materials are mixed to obtain a first mixed raw material, and the carbon-containing electric conductor raw materials comprise, by mass, 15 parts of gluconic acid, 10 parts of aluminum oxide and 55 parts of deionized water; performing hydrothermal reaction on the first mixed raw material to obtain a carbon-containing conductor precursor; the carbon-containing conductor precursor is carbonized in a protective atmosphere, a carbon-containing conductor of a core-shell structure is obtained, and the carbon-containing conductor takes aluminum oxide as an inner core and takes a conductive carbon material formed by gluconic acid as a conductive outer shell; mixing the carbon-containing electric conductor with the core-shell structure with a carbon ceramic matrix raw material to obtain a resistor blank; and sintering the resistor blank to obtain the carbon ceramic resistor. The uniformity, the stability and the reliability of the carbon ceramic resistor are improved, so that the carbon ceramic resistor can better meet the application requirements of ultrahigh-voltage and extra-high-voltage alternating-current power transmission systems.

The invention discloses a preparation method of a mesoporous Zn-ZSM-5 molecular sieve for preparing aromatic hydrocarbon from methanol, and belongs to the technical field of synthesis of inorganic materials. Aiming at the problems that a conventional mesoporous Zn / ZSM-5 molecular sieve catalyst Zn blocks orifices, the mesoporous structure is disordered, the molecular sieve solid yield is low, a molecular sieve framework is seriously damaged and the like, the preparation method comprises the following steps: uniformly mixing zinc gluconate with an aluminum source, a silicon source and a template agent, putting the mixture into a closed reaction container, carrying out hydrothermal crystallization, and sequentially washing, drying and roasting to obtain the mesoporous Zn / ZSM-5 molecular sieve catalyst. The sodium type molecular sieve is obtained; the preparation method comprises the following steps: carrying out multiple ion exchange on a sodium type molecular sieve by using an ammonium chloride solution, and sequentially carrying out suction filtration, washing, drying and roasting to obtain the mesoporous Zn-ZSM-5 molecular sieve. According to the preparation method of the methanol-to-aromatic hydrocarbon Zn / ZSM-5 molecular sieve provided by the invention, the obtained molecular sieve is used in the methanol-to-aromatic hydrocarbon process, and has the characteristics of high carbon deposition resistance, high aromatic hydrocarbon selectivity, low Zn wastage rate and the like.

A bipolar membrane in which a cation-exchange membrane and an anion-exchange membrane are joined to each other, wherein a leakage ratio of gluconic acid at 60° C. is not more than 1.0%, and the cation-exchange membrane is supported by a polyolefin reinforcing member and, further, contains a polyvinyl chloride.

The invention discloses a method for detecting glucose on the basis of cascade catalysis of cerium dioxide / gold nano cluster-Prussian blue nano enzyme (AuNCs-CeO-HMPB). The material is prepared by compounding cerium dioxide (CeO) with similar glucose oxidase activity and hollow Prussian blue nanoparticles (AuNCs-HMPB) modified by gold nanoclusters with similar peroxidase activity through a hydrothermal assembly method. In the presence of glucose, CeO catalyzes oxidation of glucose to generate gluconic acid and H2O2, then AuNCs-HMPB synergistically catalyzes decomposition of newly generated H2O2 to generate high active oxygen species, further a colorless 3, 3 ', 5, 5'-tetramethyl benzidine (TMB) color developing agent is oxidized to generate obvious color change, and based on the cascade catalytic reaction, the enzyme-free glucose colorimetric sensor is successfully constructed. The sensor shows excellent detection performance on glucose under optimized conditions (pH = 4.0, 50 DEG C), the linear detection range is 10.00-90.00 [mu] mol / L, and the detection limit is 2.1 [mu] mol / L (S / N = 3).

The invention belongs to the technical field of medicines, and particularly relates to a composition containing mesenchymal stem cells and application of the composition in preparation of products for resisting premature ovarian failure. The invention relates to a composition containing mesenchymal stem cells. The umbilical cord mesenchymal stem cell gel is prepared from the following components in percentage by weight: 10 percent of umbilical cord mesenchymal stem cells, 4 to 6 percent of human serum albumin stock solution, 1 to 2 percent of ginkgo biloba extract, 1 to 3 percent of coix seed oil, 2 to 2.5 percent of flavonol glycoside, 1.1 to 1.3 percent of vitamin E, 0.4 to 0.8 percent of glutathione, 0.5 to 1.5 percent of sodium hyaluronate, 0.5 to 1.0 percent of phycocyanin, 1.2 to 1.8 percent of zinc gluconate, 0.5 to 0.8 percent of heparin calcium, 0.1 to 0.3 percent of pH regulator and the balance of normal saline. The composition disclosed by the invention can be used for preparing products for resisting premature ovarian failure and has a very good effect.

The invention relates to the technical field of polyphenol extraction, and provides a green pear polyphenol extraction method which comprises the following steps: performing steam explosion treatment on pear residue dry powder, and then infiltrating and activating by using an aqueous solution containing L-malic acid; adding betaine and D-gluconic acid into the first part of ultrapure water to prepare a deep eutectic solvent; mixing the eutectic solvent with a second part of ultrapure water to prepare a composite extracting agent; putting the infiltrated and activated raw materials and a composite extracting agent into an extraction device to obtain an extracting solution; carrying out solid-liquid separation on the extracting solution to obtain a clear solution; and adsorbing the clarified liquid through macroporous adsorption resin, then eluting with an ethanol water solution, collecting polyphenol-rich eluent, and carrying out spray drying to obtain the pear polyphenol extract. According to the technical scheme, the quality of an extracted product is improved, and polyphenol oxidation and thermal degradation are reduced; meanwhile, the product storage stability is improved, the phenomena of wall sticking and caking of powder are reduced, and the product yield and physical properties are guaranteed.

The invention provides a capillary crystalline type waterproof agent and a preparation method thereof and a concrete material, the capillary crystalline type waterproof agent comprises a complexing agent, an active silicon component, modified silicon dioxide and a solvent, the complexing agent comprises polyvinyl alcohol grafted gluconic acid, the modified silicon dioxide comprises silane coupling agent grafted silicon dioxide, and the solvent is a solvent. The silane coupling agent contains an epoxy group. According to the invention, deep penetration, uniform distribution and long-term stable impermeability of the waterproof agent can be considered and optimized.

The invention relates to a hydrogel light-operated multi-mode synergistic treatment platform based on a CuxS-MoS2 heterojunction for promoting wound healing of diabetes mellitus. And an interface induced electric field strategy is provided through density functional theory (DFT) calculation to optimize the charge migration behavior of the phototherapy agent. The multifunctional phototherapy system is constructed by taking CuxS-MoS2 with a built-in electric field as a core and PVA-CS hydrogel loaded with glucose oxidase (GOx) as a bracket. In a weakly acidic wound microenvironment, glucose at the wound is catalyzed by GOx to be converted into H2O2 and gluconic acid; meanwhile, the CuxS-MoS2 remarkably enhances the generation of reactive oxygen species (ROS) under illumination through peroxidase-like (POD) activity, photothermal effect (PTT) and heterojunction efficient carrier separation. After entering a proliferation period, the stent exerts catalase-like (CAT) activity to remove excessive ROS and release oxygen, and oxygen deficit and oxidative stress are relieved. In addition, the controllably released copper ions regulate and control the behavior of fibroblasts, promote healing and inhibit fibrosis. Experiments prove that the stent has excellent biocompatibility, effective antibacterial property and remarkable healing promoting effect in chronic wound repair of diabetes mellitus.

The invention relates to an activated carbon electrode material for a supercapacitor and a preparation process thereof, and belongs to the technical field of activated carbon electrode materials. The preparation process provided by the invention specifically comprises the following steps: mixing cane sugar, ammonium dihydrogen phosphate, deionized water and zinc gluconate, carrying out spray drying at 80 DEG C to obtain precursor powder with a loose structure, carbonizing, then carrying out pulse activation, water vapor reaming, cooling and post-treatment, mixing the obtained composite material with carbon nanofibers, a PTFE binder and absolute ethyl alcohol, and carrying out ball milling, so as to obtain the carbon nanofiber composite material. And coating the obtained slurry with an aluminum foil, drying, rolling, and carrying out hot press molding, thereby obtaining the product. According to the invention, cane sugar is used as a carbon source, zinc gluconate is introduced to assist in forming a honeycomb-shaped pore frame, and a honeycomb-shaped porous structure is formed along with further increase of carbonization temperature and multiple cyclic pulse activation and water vapor chambering processes, so that the ion transmission efficiency is improved, and the loss of a specific capacitance value under high current density is reduced; the capacitance performance of the material is improved.

The invention belongs to the technical field of microorganisms, and particularly relates to lactobacillus helveticus YM1922 for promoting brain development, improving concentration and nourishing nerves as well as a metabolite, a complex flora, a metabolite and application. The lactobacillus helveticus YM1922 is preserved in the China General Microbiological Culture Collection Center on September 10, 2024, and the preservation number of the lactobacillus helveticus YM1922 is CGMCC No. 31928. Fermentation metabolites of the strain can promote secretion of brain-derived neurotrophic factors, and thalli can inhibit production of intestinal tract D-gluconic acid in intestinal tracts. Therefore, the strain and the metabolite thereof have application potentials of promoting brain development, improving cognitive level, improving concentration and nourishing nerves, and can be prepared into products for playing corresponding roles.

The invention belongs to the technical field of silicon material cleaning, and particularly relates to a silicon material cleaning agent and a preparation method and application thereof. The silicon material cleaning agent provided by the invention comprises the following components in parts by mass: 50-60 parts of water; 15 to 30 parts of an acidic etching solution; 10 to 20 parts of a first chelating agent; 10 to 20 parts of a second chelating agent; 0.5 to 5 parts of a surfactant; 5 to 15 parts of a builder; wherein the first chelating agent is selected from at least one of 1-hydroxyethylidene-1, 1-diphosphonic acid or ethylenediaminetetraacetic acid; the second chelating agent is selected from at least one of citric acid, gluconic acid, tartaric acid, malic acid, sodium citrate, sodium gluconate, potassium pyrophosphate and sodium pyrophosphate. The silicon material cleaning agent is used for silicon material cleaning, various metal ions can be cleaned at a time, the silicon material cleaning efficiency is improved, and the industrial cost is effectively reduced.

The invention relates to the field of food materials, and particularly discloses a gamma-aminobutyric acid and hydrolyzed egg yolk powder composite beverage capable of promoting sleep and inhibiting bone age and a preparation method of the gamma-aminobutyric acid and hydrolyzed egg yolk powder composite beverage. A gamma-aminobutyric acid and hydrolyzed egg yolk powder composite beverage capable of promoting sleep and inhibiting bone age comprises the following raw materials in percentage: 3-5% of xylitol, 3-5% of fructo-oligosaccharide, 2-4% of gamma-aminobutyric acid, 3-9% of antioxidant composite concentrated juice, 0.16-1% of purple carrot juice beverage thick slurry, 0.1-0.19% of calcium aspartate, 0.02-0.05% of casein hydrolyzed peptide, 0.02-0.05% of hydrolyzed egg yolk powder, 0.02-0.05% of casein phosphopeptide and the balance of water. The formula comprises the following components in percentage by weight: 0.006 to 0.01 percent of zinc gluconate, 0.0005 to 0.00085 percent of zinc-rich edible yeast powder, 0.0005 to 0.00085 percent of tea theanine, 0.0005 to 0.00085 percent of N-acetylneuraminic acid, 0.0018 to 0.09 percent of a traditional Chinese medicine composition, 0.005 to 0.01 percent of L-calcium lactate, 0.0005 to 0.01 percent of collagen peptide, 0.1 to 0.3 percent of xanthan gum, 0.0005 to 0.00085 percent of melissa officinalis, 0.2 to 0.98 percent of a compound flavoring agent and the balance of purified water. Through the synergistic effect of all the components, the sleep quality is effectively improved, overactivity of bone cells is inhibited, and the bone age development is delayed.

The invention relates to the technical field of cosmetics, and discloses a high-efficiency mild depilation cosmetic and a preparation method thereof, and the raw materials of the depilation cosmetic comprise, by weight, 8-10% of bromelain; 10%-12% of a turmeric root extract; 9%-11% of a calendula extract; 6%-9% of an aloe extract; 4%-7% of a soybean extract; 7%-10% of calcium thioglycolate; 2%-5% of L-cysteine; 1%-3% of sodium bicarbonate; 3%-6% of green tea polyphenol; 2%-4% of a chamomile extract; 1%-3% of dipotassium glycyrrhizinate; 0.9%-2.3% of a peptide component; 0.5%-1% of rosmarinic acid; 1%-3% of vitamin E; 2%-4% of gluconic acid; 4%-5% of beewax; 5%-10% of an emulsifier; according to the invention, dipotassium glycyrrhizinate and the chamomile extract form a dual anti-allergy barrier, the physical protection effect of aloe polysaccharide is combined to reduce skin irritation, and the turmeric root extract and the peptide component prolong the hair follicle resting period and reduce the hair regeneration rate, so that the safer and more effective hair removal cosmetic is prepared.

The invention discloses an astragaloside synergistic type composition as well as a preparation method and application of the astragaloside synergistic type composition. Comprising the following components: 8 to 16 parts of astragaloside, 20 to 40 parts of a honeysuckle flower extract, 10 to 20 parts of L-carnitine, 0.1 to 0.5 part of selenium yeast, 3 to 8 parts of diammonium glycyrrhizinate, 5 to 15 parts of taurine, 8 to 20 parts of a fructus forsythiae extract, 2 to 7 parts of vitamin E, 12 to 32 parts of hydroxypropyl-beta-cyclodextrin, 2 to 10.5 parts of maltodextrin, 1 to 7 parts of Arabic gum, 10 to 20 parts of lactose, 1 to 3 parts of zinc gluconate and 2 to 5 parts of magnesium stearate. 1-3 parts of vitamin C, 1-5 parts of xanthan gum and 1-3 parts of lecithin. The composition has a wide application prospect in preparation of veterinary drugs or veterinary food additives.

The invention relates to the technical field of oral preparations, in particular to an improved oral preparation based on traditional Chinese medicine prescription Yufengxiang powder and a preparation method of the oral preparation. The preparation comprises traditional Yufengxiang powder components such as mung beans, radix angelicae, Chinese wolfberry fruits, licorice roots and poria cocos. And modern functional components such as turmeric, grape seeds, low-molecular-weight hyaluronic acid, L-ascorbic acid, zinc gluconate, a pumpkin seed extract, black pepper pigment and a rice essence extract. The preparation method comprises the following steps: respectively extracting the raw materials, drying into powder, mixing all active components according to the formula, controlling the moisture content of the powder, and filling into an enteric capsule shell. Through dosage form improvement and formula optimization, the bioavailability of active ingredients is remarkably improved, multiple synergistic effects of whitening, oxidation resistance, moisturizing, nerve soothing, alopecia improvement and the like are achieved, and the technical problems that traditional Yufeng western style powder is low in external use absorption rate and single in function are solved.

The present application relates to the field of external ointment preparation, and provides a zinc gluconate ointment and a preparation method thereof.The ointment comprises, by mass fraction: 0.3-2.0 parts of zinc gluconate, 0.05-1.5 parts of L-histidine, 0.05-1.0 parts of polysaccharide, and the balance of purified water, wherein the polysaccharide is chitosan oligosaccharide or hyaluronic acid oligomer.The zinc gluconate, L-histidine and polysaccharide are dispersed to form hydrogel microdroplets under the condition of pH 5.0-6.0, and are further dispersed in the continuous phase of the oil phase.By establishing a complex system in a weak acid environment and using a double constraint structure of microdroplet dispersion and oil phase, the free Zn 2+ The initial release rate is reduced, skin irritation caused by the initial release of traditional preparations is avoided, and a high 24-hour cumulative release amount is maintained.The ointment exhibits excellent physical stability and particle size uniformity during storage, avoids oil-water layering and crystallization, and has both sustained release and good use feeling.

The invention belongs to the technical field of gene engineering, and discloses a promoter and application thereof in enhancing target gene expression and promoting mannitol metabolism to synthesize bacterial cellulose. The nucleotide sequence of the promoter P00300 is as shown in SEQ ID NO: 2. The promoter is obtained by site-directed mutagenesis of a wild type promoter P06915 of gluconacetobacter xylinum and screening. The promoter provided by the invention can be used for enhancing the expression of a target gene and producing a target compound. For example, the expression level of fk, mdh1 and mdh2 three-gene combination is remarkably improved, the recombinant strain can efficiently synthesize BC by using mannitol, and the yield reaches 6.1 g / L, is about 2.87 times of that of a wild strain, and is 1.27 times of that of a bla promoter in pBla. The result lays a foundation for further understanding mannitol metabolism of gluconacetobacter xylinum and for high-value conversion and utilization of marine carbon resource mannitol and BC synthesis.

The invention relates to a liquid detergent containing, based on the total weight thereof, a) 22 to 50 wt.% anionic surfactant; b) 0.1 to 8 wt.% gluconic acid salt; c) 0 to 2 wt.% antioxidant; d) 5 to 25 wt.% organic solvent; e) 0.1 to 15 wt.% water; f) less than 0.1 wt.% organic phosphonate, and g) 0.01 to 5 wt.% perfume composition.

The invention relates to the technical field of chemical preparation, and discloses a preparation method of a glucolactone crystal with controllable product granularity, which comprises the following steps: carrying out ultrasonic induced nucleation on a gluconic acid concentrated solution to generate a seed crystal, then cooling to 40-50 DEG C at a cooling rate of 0.5-1.5 DEG C / h, stirring by adopting a Taylor flow stirrer while cooling, and then cooling to 40-50 DEG C at a cooling rate of 0.5-1.5 DEG C / h to obtain the glucolactone crystal with controllable product granularity. A 45-degree four-blade axial Taylor flow stirring paddle is assembled below the Taylor flow stirrer, the rotating speed is 200-400 rpm, the ratio of the diameter of the Taylor flow stirring paddle to the inner diameter of the crystallizer is 0.4-0.8, after the cooling procedure is completed, solid-liquid separation is conducted, crystals are collected, and a glucolactone crystal product is obtained after drying treatment. The number of fine grains is controlled by changing the ratio of the diameter of the Taylor flow stirring paddle to the inner diameter of the crystallizer and the stirring speed, glucolactone crystal products with different granularities are obtained, the process is stable, the granularity of the glucolactone crystals can be effectively controlled, and the granularity of the crystal products can be finely adjusted according to actual product requirements.

The invention relates to the field of plant polysaccharide, and discloses application of lycium barbarum polysaccharide in preparation of a medicine for preventing and / or treating bone loss, monosaccharide in the lycium barbarum polysaccharide comprises detectable arabinose, glucose, galactose and gluconic acid; wherein the content of polysaccharide of which the weight-average molecular weight is greater than or equal to 6.5 kDa in the lycium barbarum polysaccharide is not less than 30wt%. Natural substances in Chinese wolfberry are adopted as active ingredients and can be safely used in an experimental dose range, bone loss is prevented or treated, particularly, Chinese wolfberry polysaccharide extracted from Chinese wolfberry is used, bone formation inhibition is relieved by competitively combining Noggin protein and blocking Noggin-BMPs interaction, and the effect of preventing or treating bone loss is achieved. The phosphorylation of Smad protein is promoted to enhance osteogenic differentiation and mineralization, and the effect of preventing or treating waste bone loss is achieved.

The invention relates to the technical field of cleaning tablets, and provides a multi-effect cleaning tablet for a kitchen waste processor and a preparation method of the multi-effect cleaning tablet. The multi-effect cleaning tablet comprises a foaming cleaning layer, an oxidation sterilization layer and a deep decomposition layer, the foaming cleaning layer is arranged on one side of the oxidation sterilization layer, the deep decomposition layer is arranged on the opposite side of the oxidation sterilization layer, and the foaming cleaning layer comprises sodium bicarbonate, gluconic acid-delta-lactone, alkyl glycoside, limonene and a chelating agent; the oxidation sterilization layer comprises sodium percarbonate, potassium hydrogen peroxysulfate, potassium carbonate, sodium citrate and a stabilizer; the deep decomposition layer comprises biological enzyme. Gluconic acid-delta-lactone is adopted in the foaming cleaning layer of the multi-effect cleaning tablet to generate gluconic acid, so that the system is prevented from instantly and violently turning over, a middle-layer peroxidation system is favorably released at a proper time, invalid decomposition is reduced, strong acid or violent pH fluctuation is prevented from permeating into an inner layer, the enzyme inactivation risk is reduced, the foaming process is mild, and the foaming effect is good. And the integral integrity of the tablet can be maintained.

The invention relates to the technical field of biology, and particularly discloses a special diet nutrient solution for promoting growth and development and a preparation method thereof. The invention discloses a special diet nutrient solution for promoting growth and development. Comprising the following raw materials in parts by weight: animal-derived collagen peptide, milk-derived peptide, isomaltooligosaccharide powder, plant-derived bioactive peptide, yeast extract, salmon nasal cartilage composite powder, cereal oligopeptide, N-acetylneuraminic acid, BioPerine black pepper extract, L-calcium lactate, zinc gluconate, magnesium gluconate, vitamin B group composition, beta-carotene powder and acerola cherry fruit powder. The sour cherry concentrated powder, the roxburgh rose powder, the seasoning components and the balance of purified water are added. The product disclosed by the invention has the advantages of being high in nutrient content, good in absorptivity and capable of promoting growth and development.

The application discloses a lithium nickel manganese oxide positive electrode material and a preparation method thereof and a secondary battery, and relates to the technical field of lithium ion battery positive electrode materials. The preparation method comprises the following steps: mixing a lithium source, a manganese source, a nickel source, a solvent and a complexing agent to obtain a mixed solution; drying to obtain a lithium nickel manganese oxide precursor; crushing the lithium nickel manganese oxide precursor by means of airflow milling to obtain crushed material, and performing pre-burning, sintering and annealing treatment on the crushed material; wherein the complexing agent comprises one or more combinations of sodium nitrilotriacetate, ethylenediaminetetraacetate, diethylenetriaminepentaacetate, tartaric acid, gluconic acid, organic carbonate, ethyl acetate, ethyl formate, alkene, alkyne, aromatic hydrocarbon and ethylene. The application guarantees good complexing effect and dispersion effect, and the size is uniform, the particle size is controllable, and the positive electrode material obtained by the application does not need secondary modification (doping or coating) and can obtain excellent charge-discharge performance.

The invention provides a inhibited foam material as well as a preparation method and application thereof, and relates to the technical field of foam material preparation. The inhibition foam material comprises the following components in percentage by mass: 10%-20% of cement, 1%-1.2% of fly ash, 1.5%-2% of an anionic surfactant, 1%-1.2% of a foaming agent, 0.3%-0.4% of a thickening agent, 3%-4% of a foam stabilizer, 0.05%-0.07% of borax, 0.1%-0.3% of gluconic acid-delta-lactone, 0.1%-0.2% of acid, 4%-5% of a dispersing agent, 4%-5% of a water reducing agent and the balance of water, and the inhibition foam material is high in compressive strength and good in plugging, inhibition and fire prevention and extinguishing effects.

The application belongs to the technical field of food processing, and particularly relates to a preparation method of a portable freeze-dried Chinese wolfberry polysaccharide solid beverage, which comprises the following steps: taking Qaidam Chinese wolfberry pomace as raw material, after pretreatment, using cellulase-assisted ultrasonic extraction and vacuum low-temperature concentration to obtain a Chinese wolfberry polysaccharide solution; then mixing the Chinese wolfberry polysaccharide solution with a probiotic auxiliary material mixture uniformly in a sterile manner, pre-freezing, freeze-drying and then dispensing to obtain a finished product. The application adopts an 'enzymatic cold extraction and vacuum low-temperature concentration' process, greatly improves the extraction rate and activity of Chinese wolfberry polysaccharide, shortens the freeze-drying time, and the prepared solid powder is portable and easy to store, convenient to brew, suitable for multiple scenes, through the compounding of probiotics and zinc gluconate and the sugar-free formula, it is suitable for sugar control groups. The application makes full use of the resource advantages of Qaidam Chinese wolfberry, solves the problems of existing product homogenization, poor portability, raw material waste and the like, and the product has both functionality and convenience.

The invention discloses a preparation method and application of an electrolyte of a full-cerium flow battery, and belongs to the field of flow batteries. The negative electrode electrolyte comprises tetravalent cerium salt, a chelating agent, supporting electrolyte and oxygen-free deionized water; the positive electrode electrolyte comprises a trivalent cerium salt, a dissolution promoter and oxygen-free deionized water; the chelating agent is one or more of citric acid, malic acid, tartaric acid, gluconic acid, succinic acid and other carboxylic acid substances. And the negative electrode is prepared by adding a carboxylic acid chelating agent into tetravalent cerium salt and supporting electrolyte. According to the obtained electrolyte, introduction of other active element impurities is reduced, the solubility of the cerium salt is improved by adding the carboxylic acid chelating agent, the redox potential of the negative cerium salt is adjusted to be more negative, the voltage of a flow battery composed of the negative cerium salt and the trivalent cerium salt is improved, and the service life of the flow battery is prolonged. And the application fields of the all-cerium flow battery in the aspects of new energy automobiles, photovoltaic energy storage, wind energy storage and the like are increased.

The invention provides a preparation method of a gluconic acid-delta-lactone crystal, which comprises the following steps: (1) adding a gluconic acid-delta-lactone seed crystal into a gluconic acid supersaturated solution to stimulate graining, and growing the crystal at 65-75 DEG C for 10-16 hours to obtain seed crystal slurry; and (2) adding a gluconic acid saturated solution into the seed crystal mush prepared in the step (1), cooling and crystallizing to obtain the gluconic acid-delta-lactone crystal. According to the method, preparation of high-quality crystal slurry and crystal seeds in a single tank body and production of large-particle lactone crystals are achieved, the problems that in the lactone production process, viscosity affects nucleation, explosion is caused, and the growth rate is not matched with pushing force are solved, and compared with a sugar retention method adopted by an enterprise in the past, the single-tank yield is increased; the obtained crystals are large in particle size, narrow in distribution and uniform in particle size, more than 60% of the crystals are more than 40 meshes, the anti-caking capability is remarkably improved, the required seed crystals are few, and industrial production can be realized.

This invention develops a pH-responsive controlled-release electrochemiluminescence sensor based on glucose oxidation and its application in the detection of CYFRA 21-1, belonging to the field of electrochemiluminescence sensor construction technology. The sensor constructed in this invention uses BSA / luminol-Ab2 / SiO2-PEI@Au NPs as the secondary antibody label and CeO2-Au as the substrate material. It utilizes the oxidation of glucose to gluconic acid under voltage, thereby lowering the pH. The sensor constructed in this invention has a wide detection range, high sensitivity, and low detection limit, providing a feasible solution for the detection of CYFRA 21-1.

The invention provides an FGF23 small-molecule inhibitor and pharmaceutical application, and belongs to the technical field of biological medicine. According to the present invention, based on the FGF23-FGFR1c binding surface, computer virtual screening is performed in LC 50KLibrary and MCE library compound libraries to screen the small molecule D-gluconic acid capable of binding FGF23; the invention provides application of D-gluconic acid or salt of D-gluconic acid in preparation of an FGF23 inhibitor and application of D-gluconic acid or salt of D-gluconic acid in preparation of a medicine for treating diseases caused by FGF23 increase. The application proves that D-gluconic acid can inhibit an FGFR1 / ERK signal channel at the downstream of FGF23, is expected to provide a new treatment strategy for diseases caused by FGF23 rise, and has patent medicine potential.

The invention relates to a large-particle dog and cat oral health-care functional food wrapped with instant freeze-dried particles and a preparation method thereof, and belongs to the technical field of pet food. According to the scheme, an external spraying system comprises grain base material particles, 0.1 to 0.15 part of lecithin, 0.002 to 0.003 part of monostearin, 0.001 to 0.003 part of vitamin E and 0.8 to 1.2 parts of chicken oil, and an instant freeze-dried particle layer comprises 0.1 to 0.2 part of fucoidan, 0.02 to 0.05 part of lysozyme, 0.04 to 0.08 part of tea polyphenol, 0.02 to 0.04 part of zinc gluconate, 0.05 to 0.1 part of Arabic gum, 0.03 to 0.1 part of glutamine, 0.01 to 0.02 part of vitamin B2, 0.01 to 0.04 part of vitamin B12 and 0.02 to 0.07 part of glycine. The toothpaste can effectively inhibit the formation of dental plaque and dental calculus and remove halitosis.