239 results about "Gluconic acid" patented technology

The invention provides a carbon ceramic resistor and a preparation method thereof, and relates to the technical field of special material production of power systems and electrical equipment. The preparation method comprises the steps that carbon-containing electric conductor raw materials are mixed to obtain a first mixed raw material, and the carbon-containing electric conductor raw materials comprise, by mass, 15 parts of gluconic acid, 10 parts of aluminum oxide and 55 parts of deionized water; performing hydrothermal reaction on the first mixed raw material to obtain a carbon-containing conductor precursor; the carbon-containing conductor precursor is carbonized in a protective atmosphere, a carbon-containing conductor of a core-shell structure is obtained, and the carbon-containing conductor takes aluminum oxide as an inner core and takes a conductive carbon material formed by gluconic acid as a conductive outer shell; mixing the carbon-containing electric conductor with the core-shell structure with a carbon ceramic matrix raw material to obtain a resistor blank; and sintering the resistor blank to obtain the carbon ceramic resistor. The uniformity, the stability and the reliability of the carbon ceramic resistor are improved, so that the carbon ceramic resistor can better meet the application requirements of ultrahigh-voltage and extra-high-voltage alternating-current power transmission systems.

A bipolar membrane in which a cation-exchange membrane and an anion-exchange membrane are joined to each other, wherein a leakage ratio of gluconic acid at 60° C. is not more than 1.0%, and the cation-exchange membrane is supported by a polyolefin reinforcing member and, further, contains a polyvinyl chloride.

The invention discloses a method for detecting glucose on the basis of cascade catalysis of cerium dioxide / gold nano cluster-Prussian blue nano enzyme (AuNCs-CeO-HMPB). The material is prepared by compounding cerium dioxide (CeO) with similar glucose oxidase activity and hollow Prussian blue nanoparticles (AuNCs-HMPB) modified by gold nanoclusters with similar peroxidase activity through a hydrothermal assembly method. In the presence of glucose, CeO catalyzes oxidation of glucose to generate gluconic acid and H2O2, then AuNCs-HMPB synergistically catalyzes decomposition of newly generated H2O2 to generate high active oxygen species, further a colorless 3, 3 ', 5, 5'-tetramethyl benzidine (TMB) color developing agent is oxidized to generate obvious color change, and based on the cascade catalytic reaction, the enzyme-free glucose colorimetric sensor is successfully constructed. The sensor shows excellent detection performance on glucose under optimized conditions (pH = 4.0, 50 DEG C), the linear detection range is 10.00-90.00 [mu] mol / L, and the detection limit is 2.1 [mu] mol / L (S / N = 3).

The invention relates to the technical field of polyphenol extraction, and provides a green pear polyphenol extraction method which comprises the following steps: performing steam explosion treatment on pear residue dry powder, and then infiltrating and activating by using an aqueous solution containing L-malic acid; adding betaine and D-gluconic acid into the first part of ultrapure water to prepare a deep eutectic solvent; mixing the eutectic solvent with a second part of ultrapure water to prepare a composite extracting agent; putting the infiltrated and activated raw materials and a composite extracting agent into an extraction device to obtain an extracting solution; carrying out solid-liquid separation on the extracting solution to obtain a clear solution; and adsorbing the clarified liquid through macroporous adsorption resin, then eluting with an ethanol water solution, collecting polyphenol-rich eluent, and carrying out spray drying to obtain the pear polyphenol extract. According to the technical scheme, the quality of an extracted product is improved, and polyphenol oxidation and thermal degradation are reduced; meanwhile, the product storage stability is improved, the phenomena of wall sticking and caking of powder are reduced, and the product yield and physical properties are guaranteed.

The invention provides a capillary crystalline type waterproof agent and a preparation method thereof and a concrete material, the capillary crystalline type waterproof agent comprises a complexing agent, an active silicon component, modified silicon dioxide and a solvent, the complexing agent comprises polyvinyl alcohol grafted gluconic acid, the modified silicon dioxide comprises silane coupling agent grafted silicon dioxide, and the solvent is a solvent. The silane coupling agent contains an epoxy group. According to the invention, deep penetration, uniform distribution and long-term stable impermeability of the waterproof agent can be considered and optimized.

The invention relates to a hydrogel light-operated multi-mode synergistic treatment platform based on a CuxS-MoS2 heterojunction for promoting wound healing of diabetes mellitus. And an interface induced electric field strategy is provided through density functional theory (DFT) calculation to optimize the charge migration behavior of the phototherapy agent. The multifunctional phototherapy system is constructed by taking CuxS-MoS2 with a built-in electric field as a core and PVA-CS hydrogel loaded with glucose oxidase (GOx) as a bracket. In a weakly acidic wound microenvironment, glucose at the wound is catalyzed by GOx to be converted into H2O2 and gluconic acid; meanwhile, the CuxS-MoS2 remarkably enhances the generation of reactive oxygen species (ROS) under illumination through peroxidase-like (POD) activity, photothermal effect (PTT) and heterojunction efficient carrier separation. After entering a proliferation period, the stent exerts catalase-like (CAT) activity to remove excessive ROS and release oxygen, and oxygen deficit and oxidative stress are relieved. In addition, the controllably released copper ions regulate and control the behavior of fibroblasts, promote healing and inhibit fibrosis. Experiments prove that the stent has excellent biocompatibility, effective antibacterial property and remarkable healing promoting effect in chronic wound repair of diabetes mellitus.

The invention discloses an astragaloside synergistic type composition as well as a preparation method and application of the astragaloside synergistic type composition. Comprising the following components: 8 to 16 parts of astragaloside, 20 to 40 parts of a honeysuckle flower extract, 10 to 20 parts of L-carnitine, 0.1 to 0.5 part of selenium yeast, 3 to 8 parts of diammonium glycyrrhizinate, 5 to 15 parts of taurine, 8 to 20 parts of a fructus forsythiae extract, 2 to 7 parts of vitamin E, 12 to 32 parts of hydroxypropyl-beta-cyclodextrin, 2 to 10.5 parts of maltodextrin, 1 to 7 parts of Arabic gum, 10 to 20 parts of lactose, 1 to 3 parts of zinc gluconate and 2 to 5 parts of magnesium stearate. 1-3 parts of vitamin C, 1-5 parts of xanthan gum and 1-3 parts of lecithin. The composition has a wide application prospect in preparation of veterinary drugs or veterinary food additives.

The invention relates to the technical field of oral preparations, in particular to an improved oral preparation based on traditional Chinese medicine prescription Yufengxiang powder and a preparation method of the oral preparation. The preparation comprises traditional Yufengxiang powder components such as mung beans, radix angelicae, Chinese wolfberry fruits, licorice roots and poria cocos. And modern functional components such as turmeric, grape seeds, low-molecular-weight hyaluronic acid, L-ascorbic acid, zinc gluconate, a pumpkin seed extract, black pepper pigment and a rice essence extract. The preparation method comprises the following steps: respectively extracting the raw materials, drying into powder, mixing all active components according to the formula, controlling the moisture content of the powder, and filling into an enteric capsule shell. Through dosage form improvement and formula optimization, the bioavailability of active ingredients is remarkably improved, multiple synergistic effects of whitening, oxidation resistance, moisturizing, nerve soothing, alopecia improvement and the like are achieved, and the technical problems that traditional Yufeng western style powder is low in external use absorption rate and single in function are solved.

The present application relates to the field of external ointment preparation, and provides a zinc gluconate ointment and a preparation method thereof.The ointment comprises, by mass fraction: 0.3-2.0 parts of zinc gluconate, 0.05-1.5 parts of L-histidine, 0.05-1.0 parts of polysaccharide, and the balance of purified water, wherein the polysaccharide is chitosan oligosaccharide or hyaluronic acid oligomer.The zinc gluconate, L-histidine and polysaccharide are dispersed to form hydrogel microdroplets under the condition of pH 5.0-6.0, and are further dispersed in the continuous phase of the oil phase.By establishing a complex system in a weak acid environment and using a double constraint structure of microdroplet dispersion and oil phase, the free Zn 2+ The initial release rate is reduced, skin irritation caused by the initial release of traditional preparations is avoided, and a high 24-hour cumulative release amount is maintained.The ointment exhibits excellent physical stability and particle size uniformity during storage, avoids oil-water layering and crystallization, and has both sustained release and good use feeling.

The invention relates to a liquid detergent containing, based on the total weight thereof, a) 22 to 50 wt.% anionic surfactant; b) 0.1 to 8 wt.% gluconic acid salt; c) 0 to 2 wt.% antioxidant; d) 5 to 25 wt.% organic solvent; e) 0.1 to 15 wt.% water; f) less than 0.1 wt.% organic phosphonate, and g) 0.01 to 5 wt.% perfume composition.

The invention relates to the technical field of chemical preparation, and discloses a preparation method of a glucolactone crystal with controllable product granularity, which comprises the following steps: carrying out ultrasonic induced nucleation on a gluconic acid concentrated solution to generate a seed crystal, then cooling to 40-50 DEG C at a cooling rate of 0.5-1.5 DEG C / h, stirring by adopting a Taylor flow stirrer while cooling, and then cooling to 40-50 DEG C at a cooling rate of 0.5-1.5 DEG C / h to obtain the glucolactone crystal with controllable product granularity. A 45-degree four-blade axial Taylor flow stirring paddle is assembled below the Taylor flow stirrer, the rotating speed is 200-400 rpm, the ratio of the diameter of the Taylor flow stirring paddle to the inner diameter of the crystallizer is 0.4-0.8, after the cooling procedure is completed, solid-liquid separation is conducted, crystals are collected, and a glucolactone crystal product is obtained after drying treatment. The number of fine grains is controlled by changing the ratio of the diameter of the Taylor flow stirring paddle to the inner diameter of the crystallizer and the stirring speed, glucolactone crystal products with different granularities are obtained, the process is stable, the granularity of the glucolactone crystals can be effectively controlled, and the granularity of the crystal products can be finely adjusted according to actual product requirements.

The invention relates to the technical field of cleaning tablets, and provides a multi-effect cleaning tablet for a kitchen waste processor and a preparation method of the multi-effect cleaning tablet. The multi-effect cleaning tablet comprises a foaming cleaning layer, an oxidation sterilization layer and a deep decomposition layer, the foaming cleaning layer is arranged on one side of the oxidation sterilization layer, the deep decomposition layer is arranged on the opposite side of the oxidation sterilization layer, and the foaming cleaning layer comprises sodium bicarbonate, gluconic acid-delta-lactone, alkyl glycoside, limonene and a chelating agent; the oxidation sterilization layer comprises sodium percarbonate, potassium hydrogen peroxysulfate, potassium carbonate, sodium citrate and a stabilizer; the deep decomposition layer comprises biological enzyme. Gluconic acid-delta-lactone is adopted in the foaming cleaning layer of the multi-effect cleaning tablet to generate gluconic acid, so that the system is prevented from instantly and violently turning over, a middle-layer peroxidation system is favorably released at a proper time, invalid decomposition is reduced, strong acid or violent pH fluctuation is prevented from permeating into an inner layer, the enzyme inactivation risk is reduced, the foaming process is mild, and the foaming effect is good. And the integral integrity of the tablet can be maintained.

The application discloses a lithium nickel manganese oxide positive electrode material and a preparation method thereof and a secondary battery, and relates to the technical field of lithium ion battery positive electrode materials. The preparation method comprises the following steps: mixing a lithium source, a manganese source, a nickel source, a solvent and a complexing agent to obtain a mixed solution; drying to obtain a lithium nickel manganese oxide precursor; crushing the lithium nickel manganese oxide precursor by means of airflow milling to obtain crushed material, and performing pre-burning, sintering and annealing treatment on the crushed material; wherein the complexing agent comprises one or more combinations of sodium nitrilotriacetate, ethylenediaminetetraacetate, diethylenetriaminepentaacetate, tartaric acid, gluconic acid, organic carbonate, ethyl acetate, ethyl formate, alkene, alkyne, aromatic hydrocarbon and ethylene. The application guarantees good complexing effect and dispersion effect, and the size is uniform, the particle size is controllable, and the positive electrode material obtained by the application does not need secondary modification (doping or coating) and can obtain excellent charge-discharge performance.

The invention provides a inhibited foam material as well as a preparation method and application thereof, and relates to the technical field of foam material preparation. The inhibition foam material comprises the following components in percentage by mass: 10%-20% of cement, 1%-1.2% of fly ash, 1.5%-2% of an anionic surfactant, 1%-1.2% of a foaming agent, 0.3%-0.4% of a thickening agent, 3%-4% of a foam stabilizer, 0.05%-0.07% of borax, 0.1%-0.3% of gluconic acid-delta-lactone, 0.1%-0.2% of acid, 4%-5% of a dispersing agent, 4%-5% of a water reducing agent and the balance of water, and the inhibition foam material is high in compressive strength and good in plugging, inhibition and fire prevention and extinguishing effects.

The application belongs to the technical field of food processing, and particularly relates to a preparation method of a portable freeze-dried Chinese wolfberry polysaccharide solid beverage, which comprises the following steps: taking Qaidam Chinese wolfberry pomace as raw material, after pretreatment, using cellulase-assisted ultrasonic extraction and vacuum low-temperature concentration to obtain a Chinese wolfberry polysaccharide solution; then mixing the Chinese wolfberry polysaccharide solution with a probiotic auxiliary material mixture uniformly in a sterile manner, pre-freezing, freeze-drying and then dispensing to obtain a finished product. The application adopts an 'enzymatic cold extraction and vacuum low-temperature concentration' process, greatly improves the extraction rate and activity of Chinese wolfberry polysaccharide, shortens the freeze-drying time, and the prepared solid powder is portable and easy to store, convenient to brew, suitable for multiple scenes, through the compounding of probiotics and zinc gluconate and the sugar-free formula, it is suitable for sugar control groups. The application makes full use of the resource advantages of Qaidam Chinese wolfberry, solves the problems of existing product homogenization, poor portability, raw material waste and the like, and the product has both functionality and convenience.

The invention provides a preparation method of a gluconic acid-delta-lactone crystal, which comprises the following steps: (1) adding a gluconic acid-delta-lactone seed crystal into a gluconic acid supersaturated solution to stimulate graining, and growing the crystal at 65-75 DEG C for 10-16 hours to obtain seed crystal slurry; and (2) adding a gluconic acid saturated solution into the seed crystal mush prepared in the step (1), cooling and crystallizing to obtain the gluconic acid-delta-lactone crystal. According to the method, preparation of high-quality crystal slurry and crystal seeds in a single tank body and production of large-particle lactone crystals are achieved, the problems that in the lactone production process, viscosity affects nucleation, explosion is caused, and the growth rate is not matched with pushing force are solved, and compared with a sugar retention method adopted by an enterprise in the past, the single-tank yield is increased; the obtained crystals are large in particle size, narrow in distribution and uniform in particle size, more than 60% of the crystals are more than 40 meshes, the anti-caking capability is remarkably improved, the required seed crystals are few, and industrial production can be realized.

This invention develops a pH-responsive controlled-release electrochemiluminescence sensor based on glucose oxidation and its application in the detection of CYFRA 21-1, belonging to the field of electrochemiluminescence sensor construction technology. The sensor constructed in this invention uses BSA / luminol-Ab2 / SiO2-PEI@Au NPs as the secondary antibody label and CeO2-Au as the substrate material. It utilizes the oxidation of glucose to gluconic acid under voltage, thereby lowering the pH. The sensor constructed in this invention has a wide detection range, high sensitivity, and low detection limit, providing a feasible solution for the detection of CYFRA 21-1.

The invention provides an FGF23 small-molecule inhibitor and pharmaceutical application, and belongs to the technical field of biological medicine. According to the present invention, based on the FGF23-FGFR1c binding surface, computer virtual screening is performed in LC 50KLibrary and MCE library compound libraries to screen the small molecule D-gluconic acid capable of binding FGF23; the invention provides application of D-gluconic acid or salt of D-gluconic acid in preparation of an FGF23 inhibitor and application of D-gluconic acid or salt of D-gluconic acid in preparation of a medicine for treating diseases caused by FGF23 increase. The application proves that D-gluconic acid can inhibit an FGFR1 / ERK signal channel at the downstream of FGF23, is expected to provide a new treatment strategy for diseases caused by FGF23 rise, and has patent medicine potential.

The invention relates to a large-particle dog and cat oral health-care functional food wrapped with instant freeze-dried particles and a preparation method thereof, and belongs to the technical field of pet food. According to the scheme, an external spraying system comprises grain base material particles, 0.1 to 0.15 part of lecithin, 0.002 to 0.003 part of monostearin, 0.001 to 0.003 part of vitamin E and 0.8 to 1.2 parts of chicken oil, and an instant freeze-dried particle layer comprises 0.1 to 0.2 part of fucoidan, 0.02 to 0.05 part of lysozyme, 0.04 to 0.08 part of tea polyphenol, 0.02 to 0.04 part of zinc gluconate, 0.05 to 0.1 part of Arabic gum, 0.03 to 0.1 part of glutamine, 0.01 to 0.02 part of vitamin B2, 0.01 to 0.04 part of vitamin B12 and 0.02 to 0.07 part of glycine. The toothpaste can effectively inhibit the formation of dental plaque and dental calculus and remove halitosis.

The application discloses a preparation method and application of a sodium alginate-cyperus esculeus protein / isolated whey protein double-network gel, and comprises the following steps: step 1, mixing cyperus esculeus protein, isolated whey protein and sodium alginate to prepare a compound; and step 2, adding gluconic acid-delta-lactone and calcium carbonate into the compound to promote gel formation, so as to obtain a sodium alginate-cyperus esculeus protein / isolated whey protein compound gel induced by calcium acetate coordination. Compared with a pure protein gel, the sodium alginate-cyperus esculeus protein / isolated whey protein compound gel has excellent performances in texture characteristics, rheological characteristics and the like, and the water retention of the compound gel is also better than that of the pure protein gel. Moreover, the double network has a good encapsulation rate for curcumin and has a good slow-release effect.

In one aspect, the invention relates to an amorphous solid form of Alpha-1062 gluconate. In another aspect, the invention relates to methods of preparing an amorphous solid form of Alpha-1062 gluconate. Also disclosed are methods for treating a brain disease associated with cognitive impairment and / or with a cholinergic deficit in a subject, including administering the amorphous form of Alpha-1062 gluconate to a subject in need thereof.

The application belongs to the technical field of natural products, and discloses purified fermentation dendrobium polysaccharide and application thereof in skin barrier repair. The application provides a fermentation dendrobium polysaccharide DOP-1A, which comprises mannose, arabinose, gluconic acid, glucose, galactose and fucose; and a fermentation dendrobium polysaccharide DOP-2A, which comprises mannose and glucose. The fermentation dendrobium polysaccharide with high purity and uniform structure is obtained by using a fermentation dendrobium powder extraction solution, alcohol precipitation and column chromatography purification. Research proves that the fermentation dendrobium polysaccharide obtained by separation and purification has the effects of skin moisturizing and skin barrier repair, and also has anti-inflammatory activity. The extraction and separation method provided by the application can efficiently extract and purify polysaccharide from fermentation dendrobium, is suitable for the fields of skin barrier repair and anti-inflammatory, and has good application prospect and value.

The present application relates to the field of food processing technology, and more particularly to a modified frozen dough with oxidized konjac polysaccharide and a preparation method thereof. The frozen dough comprises the following raw materials in parts by weight: 850-950 parts of flour, 500-600 parts of water, 2.55-9.5 parts of oxidized konjac polysaccharide, 8.5-14.25 parts of calcium gluconate, 0.25-1 part of zinc gluconate, and 8-60 parts of a leavening agent. The leavening agent is yeast or baking powder. In the preparation, the oxidized konjac polysaccharide, calcium gluconate and zinc gluconate are uniformly dispersed in water, and then subjected to high-pressure homogenization and plasma treatment. All the raw materials are put into a dough mixer, mixed at low speed for 1-3 min, and then mixed at high speed for 3-5 min. After mixing, the dough is divided into small doughs, and rolled into small balls. The doughs are wrapped with plastic wrap and quickly frozen. The frozen dough has improved stability, and the deterioration of the specific volume of the food made from the frozen dough is improved.

1. The name of the design product: packing box (zinc gluconate tablet). 2. The use of the design product: for packing box. 3. The design points of the design product: the combination of shape and pattern. 4. The picture or photo that best indicates the design points: front view.

A cleaning composition including a preservative formulation having a lactic acid salt, a gluconic acid salt, a polyhydric alcohol and optionally a phospholipid complex is disclosed. The cleaning composition can be loaded on a cleaning wipe and used for personal care. The lactic acid salt, gluconic acid salt and polyhydric alcohol provide a synergistic preservative effect to a cleaning composition incorporating the preservative formulation.

The application discloses a kind of high adhesion hydrogel for electroencephalogram test and its preparation method and application, belong to biomedical engineering technical field.The hydrogel includes the following components crosslinked product: anionic monomer, cationic monomer, monomer and mutual penetration agent;The anionic monomer is any one of malic acid, gluconic acid, citric acid and lactic acid, cationic monomer is betaine or acetyl L-carnitine, monomer is N, N-dimethyl acrylamide, acrylic acid, sodium acrylate, 4-acryloyl morpholine or sodium acrylamidomethyl propane sulfonate, mutual penetration agent is sodium chloride aqueous solution or sodium chloride water-retaining agent solution.Preparation, cationic monomer is mixed and dissolved, vacuum drying, adding photo initiator mixing, then mutual penetration agent is added, and it is obtained by ultraviolet light crosslinking.The hydrogel of the application has high adhesion (adhesion strength reaches 203.22 kPa), high ion mobility and excellent biocompatibility, and the signal gain in EEG and ECG test reaches 2-3 times of traditional conductive paste, which can be widely used in medical conductive paste field.

The invention relates to the technical field of biochemical engineering, in particular to calcium gluconate with a spherocrystal structure as well as a preparation method and application of the calcium gluconate. The calcium gluconate product with the spherocrystal structure can be prepared by adding 1.1 wt%-5 wt% of calcium carbonate ethanol water suspension into 5 wt%-20 wt% of gluconic acid ethanol water solution. Due to the unique spherocrystal structure, the calcium gluconate product has the remarkable advantages that the crystal form is regular, and the core performance of high dissolution rate, high bioavailability and good stability is achieved. The successful construction of the advantageous spherocrystal structure is characterized in that the reaction temperature, the reaction raw material input proportion, the concentration, the solvent system (ethanol-water) and the rotating speed are cooperatively regulated and controlled, and the regulation and control mechanism provides reliable technical support for stable formation of the spherocrystal structure. In addition, the preparation process disclosed by the invention is simple to operate, and has the advantages of environmental protection and no generation of pollutants.

The invention relates to a composition containing selenium gluconate and application of the composition in preparation of anti-cancer drugs. The composition comprises a shiitake mushroom extract, a chicory extract and selenium gluconate. Wherein the selenium gluconate is selenium salt of gluconic acid, has an anti-cancer effect, but is easy to generate side effects when being independently used; according to the invention, the mushroom extract, the chicory extract and the selenium gluconate are combined for use, so that the killing power of the composition on cancer cells can be synergistically improved, the immunity can be remarkably improved, the related side effects can be effectively reduced, and the damage to normal cells can be reduced.

The invention discloses a composition for improving sexual life and / or prostate symptoms and a preparation method thereof. The composition is prepared from the following components in parts by weight: 30 to 50 parts of algal polysaccharides, 15 to 25 parts of phospholipid, 8 to 12 parts of euphausia superba oil, 8 to 12 parts of magnesium oxide, 8 to 12 parts of lycopene, 2 to 4 parts of zinc gluconate, 1 to 3 parts of radix ginseng extract, 0.8 to 1.2 parts of flos sophorae immaturus extract, 0.8 to 1.2 parts of fructus rubi extract, 0.8 to 1.2 parts of mulberry fruit extract, 0.8 to 1.2 parts of fructus lycii extract and 0.8 to 1.2 parts of sodium selenite. By limiting the raw materials and the dosage, under the combined action of the raw materials, the prepared composition can improve erectile, ejaculation and anterior lacrimal gland symptoms, can improve the quality of sexual life, and has no side effect on the body.

A method for preparing stable liquid emulsion forms of plant extract is provided. A plant extract having a bitter flavor is mixed with diluent oil as an oil mixture and heat is applied to the oil mixture. An emulsifying agent is dispersed in water as an emulsifying solution. The oil mixture is mixed with the emulsifying solution. The mixed oil mixture and emulsifying solution is homogenized as a liquid form of the plant extract. Gluconic acid is added to the liquid form of the plant extract. The bitter flavor of the plant extract is disguised by adding a bitter blocker to the liquid form of the plant extract.