836results about "Ether separation/purification" patented technology

The invention belongs to the technical field of traditional Chinese medicine biology, and particularly relates to a pair of diastereoisomers in fresh bamboo juice as well as a preparation method and application of the diastereoisomers, in the diastereoisomers, a formula I is a dextroisomer and is named as (+)-fresh bamboo juice phenol A, and a formula II is a levoisomer and is named as (-)-fresh bamboo juice phenol A. According to the invention, a pair of diastereoisomer compounds (+)-fresh bamboo juice phenol A and (-)-fresh bamboo juice phenol A are successfully obtained from fresh bamboo juice, and an in-vitro cell test shows that the (+)-fresh bamboo juice phenol A has a remarkable inhibition effect on gastric cancer cells, liver cancer cells, colorectal cancer cells, bladder cancer cells and lung cancer cells of a human body; the compound can be used for preparing medicines for preventing or treating tumors, and has a wide application prospect.

The utility model discloses equipment for producing high-purity methyl ethyl ether, which relates to the field of synthesis of chemical compounds and comprises a reaction device, a heating component, a cold bath tank, a crude product receiving tank, a heavy component removal tower, a light component removal tower, a first reboiler, a second reboiler, a first condenser, a second condenser, a recovery tank, a product receiving tank and a controller, raw materials including sodium methoxide and halogenated ethane directly react under the anhydrous condition, a catalyst is not needed, crude methyl ethyl ether is produced, then the crude methyl ethyl ether enters a heavy component removal tower, crude methyl ethyl ether gas with heavy components removed enters a light component removal tower from the top of the light component removal tower after being detected to be qualified through a first online analysis and detection component, light component removal rectification is conducted, and methyl ethyl ether is obtained. Gas-phase impurities at the top of the light component removal tower are analyzed through the second online analysis and detection part, when the gas-phase impurities are detected to be qualified, the methyl ethyl ether product enters the product receiving tank, and then the high-purity methyl ethyl ether product is produced through continuous rectification, so that the product purity is high, the reaction temperature is low, the energy consumption is reduced, the reaction yield is high, and the production cost is low.

The invention discloses a refining device and method for a polymerization product and application. The refining device comprises an aldehyde removal tower, a dehydration tower, a water separation tank, a light component removal tower, a byproduct tower and a product tower. According to the present invention, the reaction product obtained through the ethylene glycol dehydration condensation reaction contains water, acetaldehyde, diethylene glycol, 1, 4-dioxane, 2-methyldioxocyclopentane and other components, and has characteristics of complex components and coexistence of multiple azeotropic pairs, and the invention provides the sequential rectification method by introducing the azeotropic breaking component according to the composition, therefore, a diethylene glycol product with high purity and byproducts of acetaldehyde and 1, 4-dioxane are separated, the process is continuous and easy to operate, and the method has industrial feasibility.

The invention belongs to the technical field of traditional Chinese medicine biology, and particularly relates to a phenolic compound and a preparation method and application thereof.The phenolic compound is a pair of diastereoisomers, the formula I of the phenolic compound is dextroisomer and is named as (+)-fresh bamboo juice phenol B, and the formula II of the phenolic compound is levoisomer and is named as (-)-fresh bamboo juice phenol B. A pair of diastereoisomer phenolic compounds (+)-fresh bamboo juice phenol B and (-)-fresh bamboo juice phenol B are successfully obtained from fresh bamboo juice, and the diastereoisomer phenolic compounds (+)-fresh bamboo juice phenol B and (-)-fresh bamboo juice phenol B have remarkable inhibition effects on gastric cancer cells, liver cancer cells, colorectal cancer cells, bladder cancer cells and lung cancer cells of a human body through in-vitro cell tests; the compound can be used for preparing medicines for preventing or treating tumors, and has a wide application prospect.

The invention belongs to the technical field of organic synthesis of ethers, and particularly relates to a method for continuously synthesizing ethylene glycol dimethyl ether. The method comprises the following steps that ethylene glycol, sodium hydroxide and methane chloride serve as raw materials, multi-stage continuous reaction is carried out in liquid membrane reactors to synthesize ethylene glycol dimethyl ether, ethylene glycol, sodium hydroxide and methane chloride are introduced into the first-stage liquid membrane reactor, sodium hydroxide and methane chloride are introduced into the subsequent stages of liquid membrane reactors, and the first-stage liquid membrane reactor and the second-stage liquid membrane reactor are connected with the second-stage liquid membrane reactor. A byproduct sodium chloride is separated from a reaction product in the previous-stage liquid membrane reactor and then enters the next-stage liquid membrane reactor, a byproduct sodium chloride is separated from a reaction product in the last-stage liquid membrane reactor and then clear liquid is obtained, and ethylene glycol dimethyl ether is obtained through rectification treatment. The invention develops a novel process mode for continuously synthesizing an ethylene glycol dimethyl ether product, and provides a new idea for large-scale continuous production of ethylene glycol dimethyl ether.

The invention belongs to the technical field of synthesis of ether organic compounds, and particularly relates to a one-pot catalyst-free method for preparing ethylene glycol dimethyl ether from ethylene glycol, which comprises the following steps: (1) adding ethylene glycol into a reaction kettle, heating to 120-140 DEG C, introducing methane chloride, and controlling the introduction amount of methane chloride to be 20-50% of the total molar amount of ethylene glycol; (2) adding NaOH into the reaction kettle in batches, and stirring for reaction at the reaction temperature of 120-140 DEG C; (3) after the last batch of NaOH is added, sampling and detecting every 20-25 minutes, and measuring the concentration lt of NaOH in the reaction liquid; and when the concentration is 0.05 mol / L, finishing the reaction, filtering, and carrying out post-treatment rectification on the filtrate to obtain the ethylene glycol dimethyl ether. The preparation raw material ethylene glycol can be derived from biomass or coal, dependence on petroleum resources is reduced, and meanwhile the preparation method has the advantages of being few in side reaction and low in production cost.

The invention relates to a preparation method of high-purity o-phenylphenoxyethanol. The preparation method comprises the following steps: S1, reacting o-phenylphenol with ethylene carbonate in the presence of a catalyst to obtain an o-phenylphenoxyethanol crude product; s2, dissolving the o-phenyl phenoxyethanol crude product in an organic solvent; and S3, adding an anti-solvent, cooling and crystallizing to obtain the o-phenylphenoxyethanol. The o-phenylphenoxyethanol obtained by the method is high in purity, namely the HPLC (high performance liquid chromatography) purity is more than or equal to 99.5%, the single impurity is less than or equal to 0.1%, the o-phenylphenoxyethanol can be produced by conventional equipment, the process operation is simple, the production cost is low, an ethylene oxide method can be replaced, and the industrial production is easy.

The invention relates to the technical field of separation and purification, in particular to a purification method of eugenol, which comprises the following steps: (a) dissolving crude eugenol in an ethanol aqueous solution to prepare a solution with eugenol mass concentration of 20-30%; (b) adding a composite protective agent into the solution, uniformly stirring and standing to obtain a mixed solution, the composite protective agent comprising modified chitosan, sodium ascorbate and nano-silica; (c) carrying out reduced pressure evaporation on the mixed solution, and recovering the solvent to obtain a concentrated solution; (d) adding the concentrated solution into a glycine aqueous solution with the mass concentration of 1-2%, uniformly stirring and standing; and (e) carrying out segmented temperature control rectification on the concentrated solution treated in the step (d), and collecting a target fraction to obtain the high-purity eugenol. By introducing a novel protective agent system and a staged temperature control rectification technology, the occurrence rate of thermal decomposition and oxidation reaction is remarkably reduced, and the product purity and the production efficiency are improved.

The present invention provides a novel crystalline polymorph of 9,9-bis[6-(2-hydroxyethoxy)-2-naphthyl]fluorene (BNEF) that is highly pure and has little coloration, and a method for producing the same. The present invention provides a method for preparing amorphous polymorphic Form B of 9,9-bis[6-(2-hydroxyethoxy)-2-naphthyl]fluorene.

The invention discloses a start-up method of an ETBE device and a production method of ETBE. The ETBE device comprises a catalytic rectifying tower newly provided with an ETBE catalyst bed, the start-up method comprises the following steps: introducing methanol into the catalytic rectifying tower to displace moisture in the ETBE catalyst bed, and when the mass content of water in a discharged material of the catalytic rectifying tower is less than 15%, starting up the catalytic rectifying tower; and introducing a C4 material into the catalytic rectifying tower, and removing methanol in the catalytic rectifying tower and the ETBE catalyst bed layer of the catalytic rectifying tower. The method has the advantages that a large amount of hydrous ethanol is not generated in the catalyst dehydration process, residual ethanol does not exist in the catalyst, dehydration raw materials are easy to obtain, the dehydration effect is enhanced, the time for starting a device is short, and the quantity of unqualified products is greatly reduced.

The invention discloses a preparation method of pentaerythritol triallyl ether, wherein the method comprises: providing reaction raw materials and a catalyst, heating to a preset temperature and keeping the temperature for a first preset time, controlling water separation in a first mode and dripping propylene chloride at a first preset speed for 5 hours to obtain a first-stage reaction product; adding alkali solution and a catalyst into the product of the previous reaction step three times and controlling water separation in a second water separation mode, a third water separation mode, and a fourth water separation mode, wherein the water separation in the first mode includes no water separation during all reaction time, the water separation in the second mode includes water separation during part of the reaction time, the water separation in the third mode includes water separation during all reaction time, and the water separation in the fourth mode includes water separation during all reaction time. By controlling different water separation modes, the selectivity of the triether can be effectively improved, the cost of pentaerythritol triallyl ether can be effectively reduced, and its application field is conducive to further expansion.

The invention provides a method for improving the selectivity of a product 3-methoxy-3-methyl-1-butanol (MMB). According to the method, the content of the isopentene methyl ether in the raw material isoprenol is controlled to be 0.005-0.25 wt%, so that the selectivity of the MMB can be effectively improved, the generation of key byproducts of isoprenol methyl ether and isoprenol methyl ether is reduced, and the purity of the MMB is improved.

The invention relates to a phenylpropanoid compound as well as a preparation method and application thereof, in particular to a phenylpropanoid compound extracted from pleione bulbus pseudobulb as well as a preparation method and application thereof, and belongs to the technical field of medicines. The invention provides a method for preparing 10 new compounds from pleione bulbocodioides pseudobulb as a raw material for the first time, systematically evaluates the anti-neuroinflammation activity of pleione bulbocodioides pseudobulb, and clarifies the application of pleione bulbocodioides pseudobulb in development and treatment of central nervous system diseases. According to the invention, abnormally activated BV-2 microglial cells induced by LPS (Lipopolysaccharide) are adopted, and the NO release amount is taken as an index, so that the effect of the compound 1-10 on inhibiting excessive activation of the microglial cells is preliminarily evaluated. The result shows that the novel compounds 1-10 can inhibit the release of LPS-induced BV-2 microglial cell NO. Therefore, the compound prepared in the invention can be applied to development of drugs for treating central nervous system diseases.

The invention relates to the technical field of functional antioxidants, in particular to a stability-enhanced antioxidant based on pterostilbene and a preparation method and application thereof. The pterostilbene tablet comprises the following components in percentage by weight: 10-30% of pterostilbene, 8-20% of Arabic gum, 5-15% of tocopheryl succinate, 1-5% of disodium ethylene diamine tetraacetate, 30-60% of beta-cyclodextrin, 2-8% of rosmarinic acid, 1-6% of chitosan quaternary ammonium salt, 0.5-3% of nano silicon dioxide and 2-7% of polyglycerol fatty acid ester. In the preparation process, beta-cyclodextrin and pterostilbene form an inclusion compound, the dispersity of nano silicon dioxide and chitosan quaternary ammonium salt is improved through hydrogen bonds, and tea polyphenol or ascorbyl palmitate can be added to enhance the synergistic effect. The antioxidant is high in stability, high in pterostilbene retention rate, uniform in dispersion, free of agglomeration, excellent in antioxidant activity, suitable for the fields of foods, cosmetics and medicines, simple in preparation process, low in consumption and suitable for industrial production.

The invention provides a reduced coenzyme Q10 eutectic crystal as well as a preparation method and application thereof. The eutectic crystal is prepared from the reduced coenzyme Q10 and L-lysine. Compared with the prior art, the prepared reduced coenzyme Q10 eutectic can effectively improve the stability of the reduced coenzyme Q10, and widens the solid existence form of the reduced coenzyme Q10. The preparation method of the reduced coenzyme Q10 eutectic crystal provided by the invention is simple, low in cost, convenient for large-scale production and favorable for subsequent product development, and particularly has important value for developing a reduced coenzyme Q10 solid oral preparation in the future.

The invention discloses an improved method for synthesis, separation and purification of 3, 3 '-dimethoxy-5, 5'-dimethyl-2, 2 '-diphenol. The invention relates to a method for preparing 3, 3 '-dimethoxy-5, 5'-dimethyl-2, 2 '-diphenol by taking 2-methoxy-4-methylphenol as a raw material and improving a synthetic route and a post-treatment method of the 2-methoxy-4-methylphenol on the basis of an existing synthetic method. According to the present invention, the single-pass yield of the 3, 3 '-dimethoxy-5, 5'-dimethyl-2, 2 '-diphenol can achieve about 75% under the optimal condition, the feeding amount is substantially reduced, the post-treatment operation is simple, the product can be obtained only through the simple operations such as distillation, neutralization, filtration, recrystallization and the like, and the high energy consumption tedious operations such as rectification, liquid-liquid extraction, column chromatography and the like are not required;

The utility model discloses equipment for removing anisole from circulating methanol, which comprises a tank body and a mixer, a plurality of baffle plates are sequentially arranged in the tank body from the mixer end to the other end, the baffle plates have three types, the left side of the baffle plate I is provided with a notch, the right side of the baffle plate II is provided with a notch, and the upper part of the baffle plate III is provided with a notch; the first baffle and the second baffle are distributed at intervals, and the third baffle is arranged at the last. The equipment disclosed by the utility model is simple in structure, easy to operate, good in removal effect of anisole in circulating methanol, friendly in production environment and low in production cost.

The invention belongs to the technical field of traditional Chinese medicine biology, and particularly relates to application of a phenolic compound in preparation of a medicine for preventing or treating hepatic fibrosis. A pair of phenolic diastereoisomers (+)-fresh bamboo juice phenol C and (-)-fresh bamboo juice phenol C are separated from fresh bamboo juice, and an anti-hepatic fibrosis activity screening test shows that (+)-fresh bamboo juice phenol C has a remarkable inhibition effect on human hepatic stellate cells LX-2, has clinical application potential in anti-hepatic fibrosis treatment, and has broad application prospects. The method can be used for preparing medicines for preventing or treating hepatic fibrosis, and a new basis is provided for pharmacological research of fresh bamboo juice.

The invention belongs to the technical field of traditional Chinese medicine biology, and particularly relates to a phenolic diastereoisomer and a preparation method and application thereof.The phenolic diastereoisomer has the chemical structural formula shown in the formula I and the formula II, the formula I is dextroisomer and is named as (+)-fresh bamboo juice phenol D, and the formula II is levoisomer and is named as (-)-fresh bamboo juice phenol D. A pair of phenolic diastereoisomer compounds (+)-fresh bamboo juice phenol D and (-)-fresh bamboo juice phenol D are successfully obtained from fresh bamboo juice, and an anti-neurotoxicity activity test shows that (+)-fresh bamboo juice phenol D has a remarkable protection effect on PC12 cell injury caused by glutamic acid and can be used for preparing medicines for preventing or treating neurodegenerative diseases; wide application prospects are realized.

The invention discloses a continuous synthesis method of 3, 5-di-tert-butyl-4-hydroxybenzyl methyl ether, and belongs to the technical field of organic synthesis. The method comprises the following steps: reacting 2, 6-di-tert-butylphenol, paraformaldehyde and methanol under the action of a dimethylamine methanol and piperazine mixed catalyst, recovering methanol through rectification, crystallizing, carrying out suction filtration, and drying to obtain 3, 5-di-tert-butyl-4-hydroxybenzyl methyl ether; secondly, the recovered devitrification filtrate can be directly and circularly used for recovering the 3, 5-di-tert-butyl-4-hydroxybenzyl methyl ether and the methanol. According to the method, dimethylamine methanol and piperazine are compounded to serve as a catalyst for concerted catalysis, generation of by-products is effectively reduced, the product yield can reach 95.75%, and the purity can reach 96.6%. According to the synthesis method, the crystallization filtrate is recycled, the product and the solvent can be fully recovered, the loss is reduced, and the cost is saved; continuous production is adopted, a purification section is avoided, operation steps and energy consumption are reduced, and the production requirements of green chemical industry are met.

The utility model belongs to the technical field of extraction equipment, in particular to extraction equipment for refining vinyl ethyl ether, which comprises a vertical rod seat and a glass ball kettle, the vertical rod seat comprises a sliding rod and a bottom plate, and a display panel is mounted at the upper end of the vertical rod seat. And a sliding rod of the vertical rod base slidably penetrates through the interior of the first connecting plate and the interior of the second connecting plate, and a stirring motor is installed on the upper side of the first connecting plate. According to the extraction equipment for vinyl ether refining, a double-thread screw is rotated, and a first connecting plate and a second connecting plate are far away from each other, so that a worker can quickly take down a glass ball kettle, place the glass ball kettle on the upper side of a connecting ring plate and reversely rotate the double-thread screw, and a connecting block completely enters a butt joint groove, so that a stirring rod normally performs stirring operation; a worker can conveniently dismount or mount the glass ball kettle of the extraction equipment, the knob is rotated, the two supporting plates can be moved out of the support of the vertical rod seat, and the stability of the extraction equipment can be enhanced through the supporting plates.

The invention provides a reduced coenzyme Q10 and gamma-aminobutyric acid eutectic crystal and a preparation method and application thereof, and belongs to the technical field of eutectic crystal manufacturing. In the eutectic crystal, the molar ratio of the reduced coenzyme Q10 to the gamma-aminobutyric acid is 1: 2, and the structural formula of the eutectic crystal is as shown in formula I. The eutectic crystal has the advantages of good stability, low cytotoxicity and strong oxidation resistance.

Systems and methods for producing MTBE are disclosed. A C4 feed stream containing isobutylene and other C4 hydrocarbons is fed into a reactor unit for producing MTBE. The effluent of the reactor unit comprising MTBE is further processed to produce a MTBE product stream that comprises at least 90 wt. % MTBE. At least a portion of the MTBE product stream is then recycled back to the reactor unit.

The invention discloses a supramolecular phase change material for long-term storage and controllable release of heat energy as well as a preparation method and application of the supramolecular phase change material. Ethyl pillar [5] arene is subjected to vacuum activation, and the obtained activated supramolecular phase change material shows controllable heat energy release in a thermal cycle process; and the stored heat energy can be released only by heating again. In addition, heat absorbed in the melting process can be stored at room temperature for more than 180 days, so that long-term storage is realized. The phase change material has the characteristics of high latent heat energy density, controllable and switchable heat energy release, long heat storage time, heat stability and the like, and has great attraction in the field of heat energy. Meanwhile, the synthesis process is simple to operate and low in equipment requirement; higher latent heat and controllable heat energy release are realized; the heat energy storage time is long.

The invention relates to the technical field of acetylene recovery treatment, in particular to a device and a method for recovering acetylene in acetylene glycol synthesis tail gas, the device comprises three condensation bodies, each condensation body comprises a condensation body, an upper seal head and a lower seal head, the top of each upper seal head is provided with a gas outlet, the bottom end of each lower seal head is provided with a liquid outlet, and the liquid outlet is communicated with the gas outlet. A condensation pipe is arranged in the condensation body; a rotating shaft is arranged in the condensation body in the axis direction, and an opening-closing assembly is installed at the top of the rotating shaft. A turntable is fixedly mounted at the bottom of the rotating shaft, a cofferdam is arranged on the turntable, a plurality of push-bearing plates are uniformly distributed on the inner wall of the cofferdam, and filter holes are formed in the bottom of the turntable; an air inlet pipe is mounted on the condensation body, the air inlet pipe is parallel to the tangent plane of the condensation body, and a pipe opening of the air inlet pipe faces the push bearing plate; according to the device and the method provided by the invention, components in the tail gas are fully separated, impurities are removed, direct use is facilitated, and the cost is saved; other substances contained in the acetylene are reduced, and the recovery purity of the acetylene is enhanced.

The invention relates to the technical field of MTBE production, in particular to a high-yield MTBE catalytic distillation device. The problem that the temperature of a reaction section in an existing device can only be roughly monitored is solved. Comprising a fixing shell, the fixing shell is rotationally connected with a partition part, the partition part is provided with storage modules which are vertically distributed at intervals, the storage modules are used for storing catalysts, flow guide folded plates which are evenly distributed in the circumferential direction are fixedly connected into the fixing shell, and the flow guide folded plates are located between every two adjacent storage modules. A temperature sensor is arranged at the bent position of the flow guide folded plate, a temperature control module is arranged on the lower portion of the flow guide folded plate, a motor is installed on the fixing shell, and an output shaft of the motor is in transmission with the partition piece through a gear set. The flow direction of materials is guided through the flow guide folded plate, so that most of the materials pass through the temperature sensor in the downward flowing process, and the monitoring precision of the device on the temperature of the materials at different positions is improved.

According to the purification method for obtaining the high-purity hydrofluoroether, the hydrofluoride salt with the acidity weaker than that of hydrofluoric acid is adopted for removing unsaturated impurities from the crude hydrofluoroether product, corresponding hydrofluoroether instead of other impurities is generated, the yield of the hydrofluoroether is increased, and the purity of the hydrofluoroether obtained after treatment is 99.3% or above and can reach 99.9% to the maximum. The method is low in cost, mild in reaction condition, short in reaction time, simple to operate, green, environment-friendly, safe, reliable and low in equipment requirement, and does not need low-temperature, water-free, oxygen-free and other conditions.

The invention relates to a process for producing polyethylene glycol by coupling a reactive distillation separation ternary water-containing azeotropic system. According to the process, excessive ethylene oxide is introduced into a ternary water-containing azeotropic system, water in the system is completely converted into polyethylene glycol to be extracted as a by-product, and the excessive ethylene oxide and residual organic components of the system are separated through a common rectification technology. According to the invention, chemical reaction and rectification separation are coupled to be carried out in one tower, reaction and separation are realized at the same time, and heat released by the reaction can reduce the thermal load of the reboiler.

The invention discloses a production system for resource utilization of fluorine-containing waste gas in production of hexafluoropropylene oxide and co-production of hydrofluoroether, which is used for resource utilization of fluorine-containing waste gas in production of hexafluoropropylene oxide and comprises an intermediate reaction system, a hydrofluoroether co-production system and a hydrofluoroether co-production system, the intermediate reaction system is used for reacting fluorine-containing waste gas in hexafluoropropylene oxide production under the action of a fluorine ion catalyst to generate a perfluorinated intermediate product; an alkylation reactor, in which the perfluorinated intermediate product reacts with an alkylation reagent under the action of a fluorination reagent to generate an alkylation product; the cleaning and drying system is used for cleaning and drying the alkylated product; the rectification system is used for rectifying the cleaned and dried alkylated product to obtain a hydrofluoroether product.

The continuous production heat pump assisted integrated extractive distillation device is adopted to realize high-purity separation and recovery of the diethyl ether-methyl formate-n-pentane azeotrope, and separation is realized by utilizing the characteristic that the extraction agent has great influence on the relative volatility of the diethyl ether-methyl formate-n-pentane azeotrope. The purity of the separated diethyl ether, n-pentane and methyl formate reaches 99.9% or above, high-purity recycling of the extraction agent can be achieved, the separation cost is greatly reduced, and the method is low in energy consumption and flexible to operate.