429results about "Ether separation/purification" patented technology

The invention belongs to the technical field of organic synthesis of ethers, and particularly relates to a method for continuously synthesizing ethylene glycol dimethyl ether. The method comprises the following steps that ethylene glycol, sodium hydroxide and methane chloride serve as raw materials, multi-stage continuous reaction is carried out in liquid membrane reactors to synthesize ethylene glycol dimethyl ether, ethylene glycol, sodium hydroxide and methane chloride are introduced into the first-stage liquid membrane reactor, sodium hydroxide and methane chloride are introduced into the subsequent stages of liquid membrane reactors, and the first-stage liquid membrane reactor and the second-stage liquid membrane reactor are connected with the second-stage liquid membrane reactor. A byproduct sodium chloride is separated from a reaction product in the previous-stage liquid membrane reactor and then enters the next-stage liquid membrane reactor, a byproduct sodium chloride is separated from a reaction product in the last-stage liquid membrane reactor and then clear liquid is obtained, and ethylene glycol dimethyl ether is obtained through rectification treatment. The invention develops a novel process mode for continuously synthesizing an ethylene glycol dimethyl ether product, and provides a new idea for large-scale continuous production of ethylene glycol dimethyl ether.

The invention relates to the technical field of separation and purification, in particular to a purification method of eugenol, which comprises the following steps: (a) dissolving crude eugenol in an ethanol aqueous solution to prepare a solution with eugenol mass concentration of 20-30%; (b) adding a composite protective agent into the solution, uniformly stirring and standing to obtain a mixed solution, the composite protective agent comprising modified chitosan, sodium ascorbate and nano-silica; (c) carrying out reduced pressure evaporation on the mixed solution, and recovering the solvent to obtain a concentrated solution; (d) adding the concentrated solution into a glycine aqueous solution with the mass concentration of 1-2%, uniformly stirring and standing; and (e) carrying out segmented temperature control rectification on the concentrated solution treated in the step (d), and collecting a target fraction to obtain the high-purity eugenol. By introducing a novel protective agent system and a staged temperature control rectification technology, the occurrence rate of thermal decomposition and oxidation reaction is remarkably reduced, and the product purity and the production efficiency are improved.

The invention relates to a phenylpropanoid compound as well as a preparation method and application thereof, in particular to a phenylpropanoid compound extracted from pleione bulbus pseudobulb as well as a preparation method and application thereof, and belongs to the technical field of medicines. The invention provides a method for preparing 10 new compounds from pleione bulbocodioides pseudobulb as a raw material for the first time, systematically evaluates the anti-neuroinflammation activity of pleione bulbocodioides pseudobulb, and clarifies the application of pleione bulbocodioides pseudobulb in development and treatment of central nervous system diseases. According to the invention, abnormally activated BV-2 microglial cells induced by LPS (Lipopolysaccharide) are adopted, and the NO release amount is taken as an index, so that the effect of the compound 1-10 on inhibiting excessive activation of the microglial cells is preliminarily evaluated. The result shows that the novel compounds 1-10 can inhibit the release of LPS-induced BV-2 microglial cell NO. Therefore, the compound prepared in the invention can be applied to development of drugs for treating central nervous system diseases.

The invention relates to the technical field of functional antioxidants, in particular to a stability-enhanced antioxidant based on pterostilbene and a preparation method and application thereof. The pterostilbene tablet comprises the following components in percentage by weight: 10-30% of pterostilbene, 8-20% of Arabic gum, 5-15% of tocopheryl succinate, 1-5% of disodium ethylene diamine tetraacetate, 30-60% of beta-cyclodextrin, 2-8% of rosmarinic acid, 1-6% of chitosan quaternary ammonium salt, 0.5-3% of nano silicon dioxide and 2-7% of polyglycerol fatty acid ester. In the preparation process, beta-cyclodextrin and pterostilbene form an inclusion compound, the dispersity of nano silicon dioxide and chitosan quaternary ammonium salt is improved through hydrogen bonds, and tea polyphenol or ascorbyl palmitate can be added to enhance the synergistic effect. The antioxidant is high in stability, high in pterostilbene retention rate, uniform in dispersion, free of agglomeration, excellent in antioxidant activity, suitable for the fields of foods, cosmetics and medicines, simple in preparation process, low in consumption and suitable for industrial production.

The invention provides a reduced coenzyme Q10 eutectic crystal as well as a preparation method and application thereof. The eutectic crystal is prepared from the reduced coenzyme Q10 and L-lysine. Compared with the prior art, the prepared reduced coenzyme Q10 eutectic can effectively improve the stability of the reduced coenzyme Q10, and widens the solid existence form of the reduced coenzyme Q10. The preparation method of the reduced coenzyme Q10 eutectic crystal provided by the invention is simple, low in cost, convenient for large-scale production and favorable for subsequent product development, and particularly has important value for developing a reduced coenzyme Q10 solid oral preparation in the future.

The invention belongs to the technical field of traditional Chinese medicine biology, and particularly relates to application of a phenolic compound in preparation of a medicine for preventing or treating hepatic fibrosis. A pair of phenolic diastereoisomers (+)-fresh bamboo juice phenol C and (-)-fresh bamboo juice phenol C are separated from fresh bamboo juice, and an anti-hepatic fibrosis activity screening test shows that (+)-fresh bamboo juice phenol C has a remarkable inhibition effect on human hepatic stellate cells LX-2, has clinical application potential in anti-hepatic fibrosis treatment, and has broad application prospects. The method can be used for preparing medicines for preventing or treating hepatic fibrosis, and a new basis is provided for pharmacological research of fresh bamboo juice.

The invention belongs to the technical field of traditional Chinese medicine biology, and particularly relates to a phenolic diastereoisomer and a preparation method and application thereof.The phenolic diastereoisomer has the chemical structural formula shown in the formula I and the formula II, the formula I is dextroisomer and is named as (+)-fresh bamboo juice phenol D, and the formula II is levoisomer and is named as (-)-fresh bamboo juice phenol D. A pair of phenolic diastereoisomer compounds (+)-fresh bamboo juice phenol D and (-)-fresh bamboo juice phenol D are successfully obtained from fresh bamboo juice, and an anti-neurotoxicity activity test shows that (+)-fresh bamboo juice phenol D has a remarkable protection effect on PC12 cell injury caused by glutamic acid and can be used for preparing medicines for preventing or treating neurodegenerative diseases; wide application prospects are realized.

The invention provides a reduced coenzyme Q10 and gamma-aminobutyric acid eutectic crystal and a preparation method and application thereof, and belongs to the technical field of eutectic crystal manufacturing. In the eutectic crystal, the molar ratio of the reduced coenzyme Q10 to the gamma-aminobutyric acid is 1: 2, and the structural formula of the eutectic crystal is as shown in formula I. The eutectic crystal has the advantages of good stability, low cytotoxicity and strong oxidation resistance.

Systems and methods for producing MTBE are disclosed. A C4 feed stream containing isobutylene and other C4 hydrocarbons is fed into a reactor unit for producing MTBE. The effluent of the reactor unit comprising MTBE is further processed to produce a MTBE product stream that comprises at least 90 wt. % MTBE. At least a portion of the MTBE product stream is then recycled back to the reactor unit.

The invention discloses a supramolecular phase change material for long-term storage and controllable release of heat energy as well as a preparation method and application of the supramolecular phase change material. Ethyl pillar [5] arene is subjected to vacuum activation, and the obtained activated supramolecular phase change material shows controllable heat energy release in a thermal cycle process; and the stored heat energy can be released only by heating again. In addition, heat absorbed in the melting process can be stored at room temperature for more than 180 days, so that long-term storage is realized. The phase change material has the characteristics of high latent heat energy density, controllable and switchable heat energy release, long heat storage time, heat stability and the like, and has great attraction in the field of heat energy. Meanwhile, the synthesis process is simple to operate and low in equipment requirement; higher latent heat and controllable heat energy release are realized; the heat energy storage time is long.

The invention relates to a process for producing polyethylene glycol by coupling a reactive distillation separation ternary water-containing azeotropic system. According to the process, excessive ethylene oxide is introduced into a ternary water-containing azeotropic system, water in the system is completely converted into polyethylene glycol to be extracted as a by-product, and the excessive ethylene oxide and residual organic components of the system are separated through a common rectification technology. According to the invention, chemical reaction and rectification separation are coupled to be carried out in one tower, reaction and separation are realized at the same time, and heat released by the reaction can reduce the thermal load of the reboiler.

The continuous production heat pump assisted integrated extractive distillation device is adopted to realize high-purity separation and recovery of the diethyl ether-methyl formate-n-pentane azeotrope, and separation is realized by utilizing the characteristic that the extraction agent has great influence on the relative volatility of the diethyl ether-methyl formate-n-pentane azeotrope. The purity of the separated diethyl ether, n-pentane and methyl formate reaches 99.9% or above, high-purity recycling of the extraction agent can be achieved, the separation cost is greatly reduced, and the method is low in energy consumption and flexible to operate.

The invention belongs to the technical field of chemical production, and particularly relates to a novel process for separating pentaerythritol by a membrane method and application of the novel process. The membrane separation comprises the steps of separating sodium formate by using an ion exchange membrane and separating pentaerythritol by using a low-pressure nanofiltration membrane device. The dealdehyding liquid is separated through different membranes, and formic acid, pentaerythritol, dipentaerythritol and other substances can be effectively separated. The process greatly shortens the process flow and saves the cost. According to the technical scheme, the quality and performance of the pentaerythritol product are remarkably improved, the added value of the product is increased, and a new technical scheme is provided for industrial production of pentaerythritol.

The invention discloses a chlorphenesin coupling crystallization-adsorption purification method based on a deep eutectic solvent, and belongs to the technical field of chemical purification. According to the technical scheme, the method comprises the following steps: S1, mixing crude chlorphenesin with supercritical CO2, and extracting to obtain pretreated chlorphenesin; s2, dissolving the pretreated chlorphenesin in a choline chloride-glycerol DES system, adding an adsorbent after sufficient dissolution, cooling, and separating out chlorphenesin. The technical problems that an organic solvent is used in an existing chlorphenesin purification method, and the solvent is inflammable, toxic, large in dosage, long in purification time and high in energy consumption are solved, and the chlorphenesin coupling crystallization-adsorption purification method based on the eutectic solvent is safe, environmentally friendly, capable of improving production efficiency and high in product purity and yield.

The invention belongs to the technical field of medical analysis, and particularly relates to a method for separating chemical components in hemsley rockvine root. According to the present invention, various chromatography methods are adopted to carry out separation and purification, such that sitroside (I), vanillyl glycolII (II), 5-hydroxymaltol (III), vanillic acid (IV), afzelin (V), 2, 3-dihydroxypyrazole (9E, 11E)-13-hydroxypyrazole (9, 11-dienoate), and 2, 3-dihydroxypyrazole (10E, 12E)-9-hydroxypyrazole (10, 12-dienoate) are obtained from hemsley rockvine root. Wherein the compounds II, III, VI and VII are separated from the hemsley rockvine root for the first time, and development and quality control of the hemsley rockvine root medicinal material are facilitated.

The application discloses an EBR solvent and a rectification preparation process thereof, and belongs to the technical field of semiconductor material processing; wherein the EBR solvent comprises the following components in percentage: 95-98% of propylene glycol methyl ether acetate and 2-5% of propylene glyyl methyl ether. The EBR solvent is prepared by rectification recovery of waste liquid generated in a dilution cleaning process, and the main steps are as follows: S1, sedimentation filtration: filtering solid impurities in the waste liquid; S2, preliminary water removal: removing part of water in the filtered waste liquid through a common distillation tank to obtain primary waste liquid raw material; S3, feeding: introducing the primary waste liquid raw material into a rectification tower for intermittent distillation purification; S4, water removal: removing water in the primary waste liquid raw material by using an extractant; S5, extractant reflux; S6, extractant extraction: after the water is removed, the extractant is extracted; and S7, EBR solvent extraction. The application solves the problem that the purity of the effective component EBR solvent in the photoresist cleaning waste liquid is not high, and the recycling effect is poor.

The application discloses a method for reducing low-temperature turbidity of fatty alcohol polyether, and belongs to the technical field of fatty alcohol polyether preparation. The method comprises the following steps: heating and stirring the low-temperature turbid fatty alcohol polyether to be transparent, adding acid or alkali, stirring under the condition of heat preservation, adding an adsorbent, continuing to stir, increasing temperature to dehydrate, cooling, stirring after the dehydration is completed, and filtering under the condition of heat preservation and negative pressure. The method can significantly reduce the turbidity of the low-temperature turbid problem product or make the problem product not appear turbidity at low temperature by means of acid treatment or alkali treatment, adsorption and low-temperature filtration.

The invention relates to a process for obtaining isobutene from an isobutene containing C4-hydrocarbon mixture (1) in a plant comprising an etherification unit (3), a first distillation unit (5), an ether cleavage unit (10) and a second distillation unit (12), the process comprising: (a) contacting the C4-hydrocarbon mixture (1) with a primary alcohol (2) and reacting the mixture with the primary alcohol in the presence of an acidic catalyst to form the corresponding alkyl tert-butyl ether in the etherification unit (3); (b) distilling the reaction mixture (4) from the etherification unit (3) in the first distillation unit (5), a C4-hydrocarbon raffinate being withdrawn as the overhead product (6), and the alkyl tert-butyl ether being withdrawn as the bottom product (7); (c) vaporizing the bottom product from the first distillation unit (5) in an evaporator (8) obtaining a vapor stream (9); (d) reacting the vapor stream (9) of step (c) in the presence of an acidic catalyst obtaining isobutene and the primary alcohol as reaction products in the ether cleavage unit (10); (e) distilling the reaction mixture (11) from the ether cleavage unit (10) in the second distillation unit (12), isobutene being withdrawn as the overhead product (13), the primary alcohol and diisobutene being withdrawn as the bottom product (14) and being recycled to the etherification unit (3); wherein a purge stream (15) containing high boiling components with a normal boiling point higher than that of the alkyl tert-butyl ether is withdrawn from the evaporator (8) in step (c).

A method for producing a (poly)alkylene glycol monoalkyl ether includes reacting an olefin and a (poly)alkylene glycol in a reactor in a presence of a catalyst. The method also includes recovering at least a portion of raw materials used for the production to use the recovered raw materials again as a raw material, where at least one of the recovered raw materials contains an olefin. A mass of a branched olefin relative to a mass sum of the branched olefin and a linear olefin contained in the recovered raw materials is controlled not to exceed 20 mass %.

[Problem] The present invention provides a production method capable of producing a larger amount of DHMBA, which is an antioxidant, with a higher concentration from the clam meat of a bivalve of Pterioidea, which is, for example, Pinctada fucata or Isognomon ephippium, than from other bivalves, by heating or pressurizing the clam meat of Pinctada fucata or Isognomon ephippium. [Solution] The present invention is characterized by putting the clam meat of a bivalve belonging to Pterioidea in an extraction solution and heating the extraction solution, thereby making it possible to produce a larger amount of 3,5-dihydroxy-4-methoxybenzyl alcohol from the heat-treated clam meat of the bivalve belonging to Pterioidea than other bivalves.

To provide an aliphatic alcohol alkylene oxide adduct in which the content of dioxane is reduced.SOLUTION: A method for producing an aliphatic alcohol alkylene oxide adduct comprises step A of adding a first alkylene oxide to an aliphatic alcohol in the presence of a perchlorate, wherein, the step A is followed by step B and step C, where the step B is a step of removing perchlorate used in the step A, and the step C is a step of removing dioxane generated in the step A.SELECTED DRAWING: None

The invention discloses a recovery method and application of ethylene glycol dimethyl ether, and belongs to the technical field of solvent recovery, and the recovery method comprises the following steps: mixing and stirring a recovery solvent and water, and standing for layering to obtain a lower water layer; distilling the water layer to obtain a distillation solvent; adding a dehydrating agent into the distillation solvent, stirring, and standing for layering to obtain supernatant liquid; and adding sodium filaments into the clear liquid for reaction, distilling and recovering ethylene glycol dimethyl ether. In conclusion, according to the recovery method and application of ethylene glycol dimethyl ether, through multi-step cooperative operation of extraction, distillation-alkaline dehydration and removal of tert-butyl alcohol from sodium filaments, accurate removal of impurities is achieved, the purity of solvent recovery in production of tert-butyl compounds is guaranteed, multiple targets of resource circulation, cost reduction and environmental protection standard reaching are achieved, and the recovery method and application of ethylene glycol dimethyl ether are suitable for industrial production. And a feasible technical scheme is provided for industrial sustainable production of the tert-butyl compound.

To provide a method capable of separating a monofunctional species, bifunctional species, etc. of a fluorinated ether compound having a polyfluoropolyether chain and a predetermined functional group in good yield and with high separation performance.A separation method for separating a compound represented by the formula (1) and a compound represented by the formula (2) from a mixture containing them by chromatography using a stationary phase and a mobile phase, wherein the mobile phase contains at least one type of specific solvent selected from a hydrofluoroolefin, a hydrochlorofluoroolefin, a chlorofluoroolefin, a cyclic hydrofluoroolefin, a cyclic hydrochlorofluoroolefin, a cyclic chlorofluoroolefin, a cyclic hydrofluorocarbon, a cyclic hydrochlorofluorocarbon, a cyclic chlorofluorocarbon and a perfluoroketone:A-(OX)m—O—Z—(R)n1  Formula (1)(R)n2—Z—(OX)m—O—Z—(R)n3  Formula (2)

The invention discloses a method for preparing anisole by taking dimethyl carbonate as a methylation reagent, a ternary concerted catalytic system is created for the first time to break through temperature limitation, phenol is efficiently activated by [BMIM] OH to generate high-activity phenoxy anions through a composite catalytic design of an alkaline ionic liquid / quaternary ammonium salt / nano metal oxide, the quaternary ammonium salt executes phase transfer and reaction path switching, and the anisole is prepared by taking dimethyl carbonate as a methylation reagent. The nano metal oxide has the effects of balance regulation and structural protection, and the conversion rate of phenol is gt according to the mass ratio of phenol to dimethyl carbonate to basic ionic liquid to quaternary ammonium salt compound to nano metal oxide being 94: (99-117): (2.82-7.52): (0.94-4.7): (0.47-3.76); the selectivity of anisole is gt; the method has the advantages that the concentration is 99%, decomposition of DMC and generation of by-products such as o-cresol are inhibited from the source, a self-settling separation-circulation method subverts a catalyst recovery mode, the by-products are directionally inhibited, the separation process is simplified, and the product can reach gt through single washing and reduced pressure distillation; and high-energy-consumption multi-tower rectification for substances with approximate boiling points in the traditional method is omitted, so that the economic benefit is greatly improved.

The application discloses a kind of miraculin compounds and its extraction method and application, belong to the field of traditional Chinese medicine extraction, specifically related to a kind of miraculin compounds as shown in general formula (I) and (II) isolated from Rhododendron dauricum and the extraction method of the compound, and the compound or the isomer of the compound, or the inhibitory effect of the compound on inflammation in pharmaceutically acceptable salt or pharmaceutical composition comprising the compound can be used for preparing anti-inflammatory drugs.The application further enriches the structural diversity of active substances of Rhododendron dauricum, which lays a foundation for subsequent related biological activity tests of monomeric compounds, provides active lead compounds for new drug development, and also provides a theoretical basis for in-depth research and development of Rhododendron dauricum medicinal materials.

The application discloses an adsorbent for removing trace metal ions in alcohol ether solvents and a preparation method and application thereof, and belongs to the field of chemical separation technology. The adsorbent is a zirconium-based metal organic cage material with discrete structure formed by coordination self-assembly of a zirconium metal salt and a nitrogen-containing polycarboxylic acid organic ligand. The adsorbent has specific ion nanowells, and can form a strong limited synergistic effect with metal ions. The adsorbent is suitable for adsorption and separation of trace metal ions in various alcohol ether solvents, and has high metal ion adsorption and removal efficiency.

To provide a process for the separation of at least one inositol from a carob extract.SOLUTION: This process comprises the steps of: a) providing a filtered and demineralised carob extract having a Brix value greater than 60 and a pinitol content, in weight percent based on the weight of the extract, from 5 to 25%; b) subjecting the carob extract of step a) to a process of chromatographic separation of the pinitol, wherein the process comprises subjecting the extract to at least one passage through a chromatographic resin, thus obtaining an aqueous solution having a pinitol content, in weight percent based on the total weight of the solution, from 35 to 70%, and which has a Brix value of 20 or lower; and c) subjecting the aqueous solution thus obtained in step b) to a purification step, thus obtaining a purified aqueous solution having a pinitol content, in weight percent based on the total weight of the solution, of more than 55%.SELECTED DRAWING: Figure 1

This application relates to the field of organic synthesis technology, specifically disclosing a process for preparing tert-butyl vinyl ether. The raw materials include solid tert-butanol, acetylene, tetrahydrofuran solvent, and potassium hydroxide catalyst, supplemented with auxiliary materials such as type 3A molecular sieves and activated alumina adsorbents. The preparation method involves: after dehydration and purification of the raw materials, the materials are introduced into a reaction vessel; temperature and pressure are controlled, and the reaction endpoint is monitored using an infrared spectrometer; byproducts are quenched and acetylene is recovered; the process involves multi-stage condensation, water washing to remove impurities, distillation separation, and solvent purification and recycling, with simultaneous integration of waste heat recovery and continuous material feeding. The tert-butyl vinyl ether prepared by this process, as an important fine chemical intermediate, can be used in coatings, adhesives, and polymer material modification, possessing advantages such as high purity and good stability. The preparation method achieves efficient utilization of materials and energy through multi-stage synergistic linkage, combining the advantages of green environmental protection, continuous and stable operation, and high resource utilization.

Provided is a method for effectively reducing the concentration of a hydrofluoroether-olefin (HFEO) contained in a mixture comprising a hydrofluoroether (HFE) and the HFEO. This method for reducing the concentration of an HFEO is one in which the HFE is a compound (A) represented by formula (1) and the HFEO is a compound (B) represented by formula (2), the method comprising reacting the compound (B) contained in the mixture with a compound (C) which is any of an alcohol, chlorine, and hydrogen.　(1): R2-O-R1-O-R3 (2): R2-O-R1-O-R4 In formulae (1) and (2), R1 is a C1-C4 alkylene group, R2 and R3 are each independently a C2-C4 fluoroalkyl group, and R4 is a C2-C4 fluoroalkenyl group.

A system for producing ether includes a first etherification reactor system containing first catalyst and producing a first reaction effluent when supplied with alcohol and olefinic hydrocarbon feedstock, a second etherification reactor system containing second catalyst and producing a second reaction effluent when supplied with the first reaction effluent, and a distillation column receiving the second reaction effluent at a feed-point between the bottom and the top of the distillation column. The produced ether is taken out from the bottom of the distillation column. Volume of the first catalyst contributing the production of the first reaction effluent is at most 15% of total volume of the first catalyst and the second catalyst contributing the production of the second reaction effluent. The first etherification reactor system acts as a guard-bed reactor which removes unwanted components from the feed and thus protects the second etherification reactor system.