155 results about "Coenzyme Q10" patented technology

The invention discloses an endogenous anti-aging composition based on an internal and external synergistic mechanism and a preparation method of the endogenous anti-aging composition. The endogenous anti-aging composition based on the internal and external synergistic mechanism is prepared from the following components in parts by mass: 100 to 200 parts of alpha-ketoglutarate calcium; 100 to 200 parts of an olive leaf extract; 10 to 20 parts of nicotinic acid; 10 to 20 parts of pyrroloquinoline quinone; 20 to 60 parts of pomegranate extract; and 10 to 30 parts of coenzyme Q10. The composition and the preparation method thereof have the beneficial effects that the composition capable of integrally improving the aging state of women from multiple dimensions and the preparation method of the composition are provided.

The invention discloses a composition containing D-chiro-inositol as well as a preparation method and application of the composition. The composition comprises D-chiro-inositol, Myo-inositol and microcapsule powder, wherein the wall material of the microcapsule powder consists of anhydride modified edible protein and a polysaccharide compound; the edible protein is selected from at least one of spirulina protein, quinoa protein, whey protein and soybean protein; the polysaccharide compound comprises at least one of fucoidin and larch arabinogalactan. Active components are also embedded in the microcapsule powder, and comprise at least one of Omega-3, coenzyme Q10, astaxanthin and vitamin. According to the composition, the stability and bioavailability of fat-soluble active ingredients are improved through microencapsulation, and the composition has a synergistic effect with components such as D-chiro-inositol and Myoinositol, so that insulin resistance is effectively improved, female hormone balance is adjusted, and polycystic ovarian syndrome is improved. The process is simple, is suitable for large-scale production, and can be widely applied to dietary supplements or functional foods.

The invention provides a reduced coenzyme Q10 and gamma-aminobutyric acid eutectic crystal and a preparation method and application thereof, and belongs to the technical field of eutectic crystal manufacturing. In the eutectic crystal, the molar ratio of the reduced coenzyme Q10 to the gamma-aminobutyric acid is 1: 2, and the structural formula of the eutectic crystal is as shown in formula I. The eutectic crystal has the advantages of good stability, low cytotoxicity and strong oxidation resistance.

The invention relates to a multi-enzyme synergistic skin care composition suitable for sensitive skin and application thereof, the skin care composition comprises the following components: crithmum maritimum extract, pomegranate peel extract, lysozyme and coenzyme Q10, the crithmum maritimum extract is obtained by anaerobic fermentation of crithmum maritimum through leuconostoc mesenteroides and lactobacillus plantarum and is rich in SOD enzyme; the pomegranate peel extract is obtained by performing anaerobic fermentation on pomegranate fruits through lactobacillus helveticus and is rich in protease and lipase. The crithmum maritimum extract, the pomegranate peel extract, the lysozyme and the coenzyme Q10 are compounded for use, a multi-dimensional synergistic skin care system is constructed, and repairing, anti-inflammatory and anti-aging integrated efficient improvement is achieved.

The invention provides methods and compositions for treatment of a subject with a glioma. The methods comprise administering a composition comprising Coenzyme Q10 to the subject by continuous intravenous infusion; and administering radiation therapy to the subject. The composition comprising Coenzyme Q10 may be administered to the subject by continuous intravenous infusion for at least 24 hours before the radiation therapy is initiated.

The invention relates to an anti-aging capsule compounded by PQQ and mitochondrial nutrients, and discloses an anti-aging capsule which is prepared by synergistically compounding a plurality of mitochondrial nutrients according to a scientific proportion and supplementing high-purity raw materials and slow-release dosage forms to realize energy metabolism activation and anti-oxidation synergistic intervention. Therefore, the anti-aging capsule systematically delays aging through multi-target regulation and control of mitochondrial functions. The capsule is characterized by comprising the following components in parts by weight: 1-20 mg of pyrroloquinoline quinone disodium salt (PQQ), 20-100 mg of coenzyme Q10, 50-200 mg of L-carnitine tartrate, 10-100 mg of alpha-lipoic acid, 50-300 mg of nicotinamide mononucleotide (NMN) or nicotinamide nucleoside (NR), and 10-50 [mu] g of selenoprotein or organic selenium yeast, and a capsule carrier comprises 100 mg of gelatin or a plant-derived capsule shell, 180 mg of microcrystalline cellulose, 5 mg of magnesium stearate and 5 mg of silicon dioxide.

This invention discloses a cardioprotective compound composition and its preparation based on improving the absorption rate of coenzyme Q10, relating to the fields of pharmaceuticals and functional foods. The core active ingredients of this composition consist of coenzyme Q10, vitamin E, and black pepper extract, with a specific mass ratio range for each. It can also be combined with pharmaceutically acceptable carriers and antioxidant synergists to prepare various oral formulations. This invention, through the construction of a ternary active component with a specific ratio, achieves in vivo synergistic effects on absorption promotion and antioxidant regeneration, solving the technical problems of low oral bioavailability and insufficient accumulation of myocardial-targeted activity in existing coenzyme Q10 preparations. It significantly improves the conversion efficiency of coenzyme Q10 into a usable active form for cardiomyocytes and can be widely applied in the preparation of drugs and functional foods for the prevention or treatment of heart diseases.

The invention discloses a functional additive composition for animal food. The functional additive composition is prepared from coenzyme Q10, glutamic acid, galactooligosaccharide, fructus lycii powder and the balance of food-grade carrier. The components of the composition cooperate with each other, so that the composition can support the effects of enhancing the physique vitality of animals, promoting nutrient absorption, helping to maintain a healthy intestinal environment and the like, has remarkable innovativeness and practicability, and is expected to create good benefits in the field of animal foods. The invention can be used in economic animals and pet animals.

The present invention relates to a liquid-phase, supplementary feed composition containing coenzyme Q10 and, more specifically, to a liquid-phase, supplementary feed composition containing coenzyme Q10, conjugated linoleic acid, fructooligosaccharide, L-carnitine, and taurine at specific contents, whereby the composition can prevent aging and onset of cardiovascular diseases and cardiac disease, activate the immune system, and provide a diet effect in companion animals.

The application provides a coenzyme Q10-producing genetically engineered bacterium and application thereof.

The invention relates to an oral cavity deodorization composition containing coenzyme Q10 and application of the oral cavity deodorization composition. The oral cavity deodorization composition is prepared from the following components: coenzyme Q10, fructus piperis longi extract, tribulus terrestris extract and centipeda minima extract. The oral cavity deodorization composition containing the coenzyme Q10, provided by the invention, is safe and healthy through the matching of the components, can exert an oral cavity deodorization function to the greatest extent, and also has certain anti-inflammatory and antibacterial effects. The oral cavity deodorization composition containing the coenzyme Q10 is simple in preparation process, low in cost and safe and stable in effect, and the prepared product is free of toxic and side effects.

The present invention relates, in part, to a method of treating epidermolysis bullosa (EB) in a subject in need thereof, comprising topically administering to the subject a pharmaceutical composition comprising a therapeutically effective amount of coenzyme Q10 (CoQ10).

The application provides a coenzyme Q10-producing genetically engineered bacterium (Rhodobacter sphaeroides), and the preservation number is CGMCC NO.19600. The application also provides application of the coenzyme Q10-producing genetically engineered bacterium CGMCC NO.19600 in fermentative production of coenzyme Q10. The coenzyme Q10-producing genetically engineered bacterium constructed by the application can greatly improve the yield of coenzyme Q10, and has a wide industrial application prospect.

The invention relates to a coenzyme Q10 soft capsule and a preparation method thereof, and belongs to the technical field of health care products. The problems that an existing product wall material is insufficient in compactness and poor in stability, and contents are prone to seeping out are solved. The soft capsule is composed of a content and a wall material according to a specific mass ratio, the content contains coenzyme Q10, soybean oil, vitamin E and phospholipid, and the wall material contains gelatin, glycerin, an aloe-tremella mixed extract and purified water. The aloe-tremella mixed extract is prepared through pretreatment of fresh aloe, preparation of tremella powder, construction of a mixed system, ultrasonic extraction and post-treatment, natural active mucopolysaccharide and tremella polysaccharide contained in the aloe-tremella mixed extract can be synergistically crosslinked, and the aloe-tremella mixed extract, gelatin and glycerin jointly construct a compact wall material structure. The preparation method is simple in process, easy in parameter control and free of special equipment, the product can improve illumination and oxidation stability and reduce the content exudation rate, physicochemical properties and use safety are both considered, and the preparation method is suitable for industrial production.

This invention belongs to the field of anti-aging functional food technology, specifically relating to an anti-aging and longevity composition containing inactivated Akkermansia myxophilus. Existing anti-aging products are mostly single-ingredient products. The composition of this invention contains inactivated Akkermansia myxophilus, NMN, coenzyme Q10, resveratrol, and astaxanthin. This invention achieves the effects of delaying aging, improving muscle strength, and enhancing cognitive function by repairing the intestinal barrier, increasing NAD+ levels, and activating longevity pathways. The composition of this invention is stable at room temperature and can be formulated into capsules or powder.

The invention discloses an anti-aging composition as well as a preparation method and application thereof. The composition is prepared from the following components in parts by weight: 10 to 50 parts of ergothioneine; 5 to 25 parts of coenzyme Q10; 50 to 150 parts of 3-SL; 50 to 150 parts of collagen tripeptide; 100 to 500 parts of NAD (nicotinamide adenine dinucleotide); and 50 to 150 parts of glutathione. According to the anti-aging composition disclosed by the invention, various functional components such as the ergothioneine, the coenzyme Q10, the 3SL, the collagen tripeptide, the NAD < + > and the glutathione are reasonably proportioned, so that the anti-aging composition shows a remarkable synergistic anti-aging effect in in-vitro and in-vivo experiments. The anti-aging composition can enhance the cell antioxidant capacity, reduce the active oxygen level and promote the expression of collagen I and SIRT1, and compared with a single component or a non-optimized combination, the anti-aging effect is remarkably improved.

A micronutrient composition comprises of several combinations of individual ingredients in forming Mix 11, G12, G13 and core mix formulation. Core mix contains magnesium citrate, alpha-Ketoglutaric acid, L-Citrulline and Taurine. The Mix 11, G12 and G13 contains Magnesium Citrate, Alpha-Ketoglutaric Acid, Niacinamide, L-Glutamine, L-Citrulline, Sodium Pyruvate, Succinic acid, Vitamin B complex, Taurine, L-Cysteine, L-Methionine, L-Ascorbic Acid, Coenzyme Q10 or combination thereof. A method of administering and treating a specific disease which is due to one of an oxidative stress, impaired mitobiogenesis and ATP production in a mammal is disclosed.

The application relates to the technical field of feed additives, and discloses a monensin premix and a preparation method thereof.The raw material composition of the monensin premix comprises monensin, a carrier, a surfactant, a binder, amino acid chelated trace elements, vitamin E, ascorbic acid palmitate and coenzyme Q10.The preparation method comprises the following steps: S1, stirring and mixing monensin and the carrier to prepare a mixture I; S2, dissolving the binder in a water bath at 80-100 DEG C, cooling to room temperature, adding the mixture I and the remaining raw materials, and stirring and mixing to prepare a mixture II; S3, uniformly treating the mixture II to prepare an intermediate product; and S4, preparing the intermediate product into granules by using a spray drying method, so that the monensin premix is obtained.The monensin premix prepared by the application is uniform in granularity, good in stability and uniformity, and high in drug efficacy.

The application belongs to the technical field of medicine, and specifically discloses a kind of nasal spray composition and nasal spray and application, the nasal spray composition includes the following components: hyaluronic acid, trehalose, N-acetyl-L-cysteine, methylene succinic acid, gallic acid, taurine, coenzyme Q10, rosemary essential oil.The nasal spray composition provided by the application is accurately adjusted, can give full play to the advantages of each component, provide better nasal ventilation and humidity.The nasal spray composition provided by the application can inhibit the excessive activation of LPS-induced neutrophil Netosis in vitro culture and the excessive activation of LPS-induced mouse airway neutrophil Netosis, thereby reducing the inflammatory response in the nasal cavity.

The invention relates to an formulation for cardiac support supplements and the method of its preparation by using molecular-level mixing technology. The method involves preparing molecular-level emulsions of alpha-lipoic acid, acetyl L-carnitine, and coenzyme Q10, followed by spray drying to produce a homogeneous powder premix. This approach ensures precise dosage control, enhanced bioavailability, and improved stability, making it a valuable advancement in the field of nutraceutical and pharmaceutical formulations.

The invention provides a coenzyme Q10 lipid nanocrystal which is prepared from the following raw materials in percentage by mass through a hot melt extrusion method: 10%-58% of coenzyme Q10, 9.09%-30% of glyceryl monostearate, 14.28%-20% of polysorbate 80 and 14.28%-45% of a water-soluble carrier, and the total amount of all the raw materials is 100%. The particle size of the coenzyme Q10 lipid nanocrystal ranges from 537.2 nm to 936.5 nm; the solid lipid and the water-soluble carrier are combined to serve as a dispersing agent of the coenzyme Q10, so that the coenzyme Q10 can be dispersed in the combined material in a nanocrystal form, the lipid nanocrystal with high drug loading capacity is obtained, the prepared coenzyme Q10 nanocrystal can be quickly dispersed and dissolved out in water, and the preparation method is simple in preparation condition, short in time, low in cost and suitable for industrial production. The method is suitable for industrial production.

Disclosed are a self-emulsifying composition of a coenzyme Q10 with high bioavailability, and a method and device for preparing the same. The composition includes the following components in percentage by weight: 5-35% of a coenzyme Q10, 1-50% of an oil phase, 10-60% of a surfactant, 1-10% of a cosurfactant, 0-7% of an antioxidant, and 0.5-2% of pyrroloquinoline quinone disodium salt. The coenzyme Q10 medicinal liquid obtained can be kept in a clear and transparent solution state at room temperature, can be stably dispersed in water and self-emulsified to a transparent emulsion, significantly improves the bioavailability of the coenzyme Q10 by more than 4 times, and can be filled in capsules or softgels to swallow. The method disclosed by the disclosure includes two steps: material grinding and vacuum self-emulsifying. The method is concise in step and easy to control. Moreover, the device is simple in structure and low in cost.

The application relates to the technical field of inclusion compounds, in particular to a coenzyme Q10-cyclodextrin inclusion compound and a preparation method and application thereof, which comprises the following steps: dissolving coenzyme Q10 in an alcohol aqueous solution to obtain a first solution; performing ultrasonic treatment on the first solution at 40 DEG C-45 DEG C to obtain a second solution; performing cooling treatment on the second solution to obtain a third solution; adding a cyclodextrin derivative solution into the third solution to mix, and obtaining a fourth solution of the coenzyme Q10-cyclodextrin inclusion compound; adding corn starch into the fourth solution, stirring and reacting, removing a solvent, and obtaining a coenzyme Q10-cyclodextrin derivative corn starch inclusion compound. The preparation method has the advantages of simple operation and high encapsulation rate, and the coenzyme Q10-cyclodextrin derivative corn starch inclusion compound has good long-term storage stability.

The present invention discloses a heart-protective complex composition for improving the absorption rate of Coenzyme Q10 and a preparation method thereof, relating to the technical field of medicine and functional foods. The core active ingredients comprise Coenzyme Q10, Vitamin E, and black pepper extract within a specific mass ratio range. Pharmaceutically acceptable carriers and antioxidant synergists may also be combined to prepare various oral dosage forms. By constructing a ternary active component system with a specific ratio, the present invention achieves temporal synergy between absorption promotion and antioxidant regeneration in vivo, thereby solving the technical problems of low oral bioavailability and insufficient myocardial targeted accumulation of existing Coenzyme Q10 preparations. It significantly enhances the conversion efficiency of Coenzyme Q10 into the active form available to myocardial cells, and can be widely used in the preparation of drugs or functional foods for preventing or treating heart diseases.

The present invention relates to a nutritional vitamin complex for pets intended to improve the fur and skin quality of pets such as dogs and cats. The composition of the complex contains omega-3, curcumin, piperine, biotin (vitamin H or vitamin B7), vitamin B2 (riboflavin), vitamin B3 (nicotinic acid or niacin), vitamin B5 (pantothenic acid), vitamin B6 (pyridoxine), vitamin B12 (cyanocobalamin), folic acid (vitamin B9), vitamin E (alpha-tocopherol), vitamin C, zinc (zinc glycine chelate), coenzyme Q10, hydrolysed type II collagen, astaxanthin, DL-methionine, selenium, L-glycine, L-proline, L-phenylalanine, L-leucine, L-isoleucine, L-histidine, L-arginine, L-lysine, L-tyrosine, resveratrol, and a flavouring agent.

To provide a coenzyme Q10-containing drink yogurt that goes down well in the throat and retains the full flavor derived from fermented milk without any loss of taste even if containing a high level of coenzyme Q10, and that has also excellent uniform dispersibility of coenzyme Q10, and to provide a method for producing the same.SOLUTION: Provided is a coenzyme Q10-containing drink yogurt, which is a drink yogurt that contains coenzyme Q10 by 0.02 to 0.3 wt.% in the whole drink yogurt and also contains a thickener of 0.4 wt.% or less, the drink yogurt made by mixing an oil-in-water type emulsion comprising water and coenzyme Q10 with fermented milk, followed by homogenization. An oil-in-water type emulsion having a content of the coenzyme Q10 of 0.045 to 2.1 wt.% in the whole oil-in-water type emulsion is contained by 14 to 46 wt.% in the whole drink yogurt. A milk protein derived from the fermented milk having a content of milk protein in the whole raw material mix of the fermented milk of 2.4 to 6.4 wt.% is contained by 2 to 3.5 wt.% in the whole drink yogurt. The milk protein / the coenzyme Q10 (weight ratio) in the drink yogurt is 8 to 40. The fermented milk is a fermented milk that underwent lactic acid fermentation to a pH of 4 to 5. The coenzyme Q10 in the oil-in-water type emulsion is oil droplets having a median diameter of 0.2 to 4.5 μm.SELECTED DRAWING: None

This invention discloses a multi-target anti-aging composition and its application in cosmetics. By weight, it comprises the following ingredients: 0.001–3 parts hydroxypinazone retinate, 0.01–5 parts hydroxypropyl tetrahydropyranotriol, 0.01–0.5 parts recombinant human collagen, 0.5–3 parts tocopheryl acetate, 0.1–5 parts glyceryl glucoside, 0.01–5 parts Babao Essence Extract, 0.01–0.5 parts carnosine, 0.5–2 parts 3000 peptides, 0.1–5 parts Bifida ferment lysate, 0.01–0.5 parts coenzyme Q10, and 0.1–5 parts black tea fermentation product. This multi-target anti-aging composition targets four aspects: anti-aging, anti-oxidation, anti-glycation, and anti-photochemical activity. The four categories of components work synergistically to significantly enhance the anti-aging efficacy of the product. Human efficacy evaluation tests show that after using the product of this invention for 28 days, the elasticity of the skin around the eyes is significantly increased, the firmness and roughness of the skin around the eyes are significantly improved, and the area, volume and depth of wrinkles at the corners of the eyes are significantly improved.

The present invention relates to a nutritional vitamin complex for pets intended to improve the fur and skin quality of pets such as dogs and cats. The composition of the complex contains omega-3, curcumin, piperine, biotin (vitamin H or vitamin B7), vitamin B2 (riboflavin), vitamin B3 (nicotinic acid or niacin), vitamin B5 (pantothenic acid), vitamin B6 (pyridoxine), vitamin B12 (cyanocobalamin), folic acid (vitamin B9), vitamin E (alpha-tocopherol), vitamin C, zinc (zinc glycine chelate), coenzyme Q10, hydrolysed type II collagen, astaxanthin, DL-methionine, selenium, L-glycine, L-proline, L-phenylalanine, L-leucine, L-isoleucine, L-histidine, L-arginine, L-lysine, L-tyrosine, resveratrol, and a flavouring agent.

The present invention provides regimens and methods for treating cancer, including continuous infusion of coenzyme Q10. Coenzyme Q10 can be administered as a monotherapy or in combination with other agents, such as anti-cancer agents, chemotherapeutic agents, or anti-angiogenic agents. Coenzyme Q10 can be administered at two or more different rates.