492 results about "Coenzyme Q10" patented technology

The present invention relates to a method and transdermal pharmaceutical composition for preventing or reducing the likelihood of calcium deficiency or imbalances caused by calcium deficiency. The transdermal pharmaceutical composition includes a therapeutically effective amount of a pharmaceutically acceptable salt of calcium and a pharmaceutically acceptable carrier constituting a pluronic lecithin organogel. In addition to calcium, the transdermal pharmaceutical composition may also contain a therapeutically effective amount of: (1) a pharmaceutically acceptably salt of other minerals such as magnesium, zinc, selenium, manganese, or chromium; (2) a vitamin such as vitamin A, vitamin D, vitamin C, vitamin E or B-complex vitamins, choline, lecithin, inositol, PABA, biotin, or bioflavomoids; (3) a carotenoid such as lycopene or lutein; (4) a hormone such as dehydroepiandrosterone, progesterone, pregnenolone, or melatonin; (5) an amino acid such as arginine, glutamine, lysine, phenylalanine, tyrosine, GABA, tryptophan, carnitine, or acetyl-l-carnitine; (6) a fatty acid such as a fish oil or flax seed oil; (7) a vita-nutrient such as coenzyme Q10; (8) a cartilage building nutrient such as glucosamine, chondroitin, or MSM, (9) a herb such as ginkgo biloba, echinacea, 5-HTP, St. John's wort, or saw palmetto; or (9) any combination thereof. The transdermal pharmaceutical composition may be topically administered to a human to prevent or reduce the likelihood of calcium deficiency or imbalances caused by calcium deficiency such as hypertension, high cholesterol, colon and rectal cancer, osteomalacia, rickets, osteoporosis, cardiovascular disease, preeclampsia, tooth decay, and premenstrual syndrome.

The present invention provides novel dietary supplement compositions based on the use of a particular oil phase which comprises of Coenzyme Q10 and optionally other lipophilic dietary ingredients of low water solubility and a liquid mixture which comprises one or more emulsifiers, a fatty acid monoester formed between an short chain alcohol of C1 to C4 chain length and a saturated, or mono-unsaturated, or di-unsaturated (both conjugated and non-conjugated) fatty acid of C6 to C24 chain length, or medium chain mono-/di-esters, or the mixture of above. The composition is in a form of self-emulsifiable in the aqueous medium, for example, a simulated gastric fluid, which should provide a high oral bioavailability for the lipophilic dietary ingredients.

Chronic glaucoma, cataract, ocular and periocular aging are treated and prevented by the administration of agents that affect metabolic subsystems such as (i) mitochondrial bioenergetics, (ii) free radical moderation and glutathione maintenance, (iii) constitutive nitric oxide/endothelin-1 balance, and (iv) calcium wave signaling and associated neuronal excito-toxicity. Included among the agents are tetrahydrobiopterin, R-alpha-lipoic acid, coenzyme Q10, 17 alpha-estradiol, and glutathione.

The invention discloses an external skin care product capable of adjusting skin immunity and delaying skin aging. The external skin care product is characterized by comprising powder, an aqueous solution and emulsion, wherein the powder comprises oligopeptide-1 and ginsenoside; the aqueous solution comprises glycyrrhiza glabra root extract, artemisia capillaris flower extract, mulberry root extract, jujube fruit extract, scutellaria root extract, hydrolyzed rice protein and nicotinamide; and the emulsion comprises hgytantriol bifida ferment lysate, creatine, carnosine, alpha glucosyl hesperidin, hexapeptide-3, centella asiatica extract, coenzyme Q10 inclusion complex, opuntia ficus-indica stem extract, rhodiola rosea extract, saussurea involucrate extract, pseudo-ginseng root extract and Chinese angelica extract inclusion complex. According to the external skin care product, the powder, the aqueous solution and the emulsion are jointly used, and the external skin care product can reduce wrinkle and pachulosis, even skin tone and improve skin elasticity and skin firmness, so that the skin is finer and smoother and looks young.

A composition having an antioxidative activity, especially, having a sufficient activity for removing active oxygen and/or free radicals is provided.

The composition includes both reduced coenzyme Q₁₀ and a carotenoid, and the activity for removing active oxygen and/or free radicals is synergistically enhanced. A method for removing active oxygen and/or free radicals by using the composition containing both reduced coenzyme Q₁₀ and a carotenoid is also provided.

The present invention has its object to provide a method for stabilizing reduced coenzyme Q₁₀, which is usable as foods, functional nutritive foods, specific health foods, nutritional supplements, nutrients, animal drugs, drinks, feeds, cosmetics, medicines, remedies, preventive drugs and the like.

Reduced coenzyme Q₁₀, which is readily oxidized in the air, is stabilized by causing ascorbic acid or a related compound thereof to coexist with a polyglycerol fatty acid ester with a polymerization degree of glycerol being not lower than 3 and/or a condensed ricinoleic acid polyglyceride in a mixture of the reduced coenzyme Q₁₀ and an oil and fat.

The invention relates to a toothpaste containing coenzyme Q10 and a preparation method thereof, in particular to a composition of toothpastes, belonging to the field of oral healthcare products; based on weight percentage, the coenzyme Q10 in the toothpaste is 1-2% and Chinese herbal extract is 0.5-2%; the rest of accessories are conventional materials for preparing toothpastes. The formulation proportion of the components in the toothpaste is preferably as follows: 2% of coenzyme Q10 mixture, 0.7% of Chinese herbal extract, 35% of abradant, 1.5% of bonding agent, 35% of wetting agent, 0.2% of flavoring agent, 2.5% of foaming agent, 1.5% of essence and 21.6% of deionized water. The toothpaste containing coenzyme Q10 has the healthcare functions the same as the common toothpastes, such as brightening and cleaning the teeth, stopping bleeding of gums and healing oral ulcer; besides, the coenzyme Q10 and Chinese herbal extract permeate the gum cell membrane so that the gum cell obtains energy and tissue vigor is strengthened, thereby essentially conserving the gums, preventing periodontitis, gingivitis and gingival atrophy to reach the aim of strengthening the gums and fixing teeth.

Disclosed are oral care compositions effective to control mouth and breath malodour comprising in a pharmaceutically acceptable carrier, a combination of an antibacterial agent and a deodorizing or odor-neutralizing agent comprising a compound having the structure

wherein R¹, R², R³, and R⁵ may be identical or different, each representing H, a linear or branched C1-C6 alkyl or alkenyl, phenyl, —OH or —OR^a; R⁴ is —OH, —OR^a, phenyl, or a linear or branched C1-C6 alkyl or alkenyl; and R^a is phenyl or a linear or branched C1-C6 alkyl or alkenyl. The odor-neutralizing agent may further comprise one or more of an additional odor-neutralizing compound selected from α-damascenone, α-isomethylionone, α-ionone, β-ionone, pulegone, piperitone, carvone, coenzyme Q10 or cinnamaldehyde.

The antibacterial agent may comprise one or a mixture of a quaternary ammonium compound selected from cetylpyridinium chloride, tetradecylpyridinium chloride, N-tetradecyl-4-ethyl pyridinium chloride or domiphen bromide; metal ions such as stannous, zinc or copper; chlorhexidine; triclosan; triclosan monophosphate; or selected essential oils.

The present invention provides a particulate composition wherein an oil component containing reduced coenzyme Q₁₀ is polydispersed forming a domain in a matrix containing a water-soluble excipient, which simultaneously shows high oxidative stability and high oral absorbability, a production method thereof, and a stabilizing method thereof. It also provides a food, food with nutrient function claims, food for specified health uses, dietary supplement, nutritional product, animal drug, drink, feed, pet food, cosmetic, pharmaceutical product, therapeutic drug, prophylactic drug and the like, which contain the composition.

A coenzyme Q₁₀ and ceramide-containing preliposome, and pharmaceutical preparations and cosmetics containing the same. The preliposome can further comprise other lipid components. A granular and lyophilized solid-preparation is produced by lyophilization or spray drying. Then, the coenzyme Q₁₀-containing proliposome is obtained by adding water in the said solid-preparation and shaking. Transdermal absorption of coenzyme is improved together with the effect of coenzyme Q₁₀ in cosmetics and the stability of coenzyme Q₁₀ and liposome, which facilitate the formulation of cosmetics.

The invention discloses a method for extracting coenzyme Q10 from microorganisms, wherein the ultrasonic disintegration is to mix microorganisms with the ability of producing the coenzyme Q10 and an organic solvent in which the coenzyme Q10 is well dissolved according to the mass volume ratio of 1-5 to 10-20, and to obtain the coenzyme Q10 after ultrasonication at a temperature of 0 DEG C, wherein the ultrasonic frequency is between 0.2 and 0.8 and the power is between 300 and 500 watts; and the alkaline splitting method is to extract the coenzyme Q10 from fermentation broth of Rhodobacter sphaeroides. The microorganisms are preferred to be microorganisms of the Rhodobacter sphaeroides. The method for extracting the coenzyme Q10 has the advantages of high efficiency, low pollution, low requirements on apparatuses and equipment, low cost and so on, and is suitable for promotion and application.

A composition and method for treating periodontal infections and gingivitis includes an extract of Centipeda cunninghami, coenzyme Q10, aloe vera and folic acid. The composition also contains additional plant extracts and nutrients that are effective in cell reproduction, wound healing and provide antibacterial and anti-inflammatory effects. The composition is applied to the teeth and gums to inhibit bacterial growth and reduce inflammation of the gums.

The invention relates to a method for preparing a separation coenzyme Q10, and in particular relates to a method for preparing a high-purity coenzyme Q10 in a large scale. The method comprises the following steps of: carrying out supercritical extraction on dry thallus containing the coenzyme Q10 to obtain extract liquor; and carrying out alkali treatment on the extract liquor to obtain a column loading liquid, carrying out column chromatography on the column loading liquid to obtain an eluent, concentrating the eluent, and crystallizing with ethanol to obtain the high-purity coenzyme Q10 with the purity higher than 99.5%. When the method provided by the invention is used for producing the coenzyme Q10, the overall yield is higher than 90%, and cost is low, thus the method provided by theinvention is applicable to industrial production.

The invention discloses a skin care composition, wherein the composition mainly comprises the following materials according to parts by weight: 0.1-5 parts of L-fucose, 0.05-5 parts of coenzyme Q10, 0.1-5 parts of hyaluronic acid, 0.05-2 parts of ceramide, and 1-25 parts of mPEG. The skin care composition can be prepared into any common skin care preparation. In addition, the invention further discloses application of the composition in preparation of the skin care composition having the functions of preventing aging and skin inflammation and moisturizing.

The present invention provides a stabilization method, a preservation method and the like method of reduced coenzyme Q₁₀, which is useful as functional nutritive foods, specific health foods and the like. Furthermore, the present invention provides a method for efficiently obtaining reduced coenzyme Q₁₀ of high quality and by a method suitable for a commercial production.

It is possible to handle and stably preserve reduced coenzyme Q₁₀ under a condition that oxidation by a molecular oxygen is inhibited by contacting reduced coenzyme Q₁₀ with an ascorbic acid and citric acid or a related compound thereof, and thus a stabilized composition is obtained. Moreover, reduced coenzyme Q₁₀ is converted into a crystalline state in such a condition that the formation of oxidized coenzyme Q₁₀ as a byproduct is minimized by crystallizing reduced coenzyme Q₁₀ in the presence of ascorbic acid or a related compound thereof, etc., and thus a reduced coenzyme Q₁₀ crystal of high quality is produced. Furthermore, by successively crystallizing the generated reduced coenzyme Q₁₀ in the presence of ascorbic acid or a related compound thereof after reducing oxidized coenzyme Q₁₀ to reduced coenzyme Q₁₀ using ascorbic acid or a related compound thereof, operations are simplified and minimized, and thus reduced coenzyme Q₁₀ of high quality is produced.

The present invention provides a method for stabilizing reduced coenzyme Q₁₀, which is useful as a food, nutritional product, nutritional supplement, animal drug, drink, feed, cosmetic, pharmaceutical product, therapeutic drug, prophylactic drug and the like. The present invention also provides a method of producing a reduced coenzyme Q₁₀-containing composition which includes the co-presence of reduced coenzyme Q₁₀ and reduced coenzyme Q₉ and/or reduced coenzyme Q₁₁.

The invention relates to a dermatological pharmaceutical composition for the treatment of skin inflammation diseases, such as dermatitis, atopic dermatitis, vitiligo, alopecia areata, acne, psoriasis and pruritus. The invention comprises a base anti-inflammatory agent, such as indometacin; one or more optional active ingredients selected alternatively from among at least a corticoid and an antibiotic; and a combination of topical antioxidants used to potentiate the anti-inflammatory effect, selected from among green tea, lipoic acid, curcumin, ascorbyl palmitate, Coenzyme Q10, resveratrol, Pycnogenol™, L-camosine, taurine, vitamin E, vitamin C, papaya extract, isoflavones, manganese, lycopene and quercetin. At least one of the topical antioxidants is a peroxisome proliferator-activated receptor-gamma (PPAR-γ) activator. The invention also includes at least one antioxidant substance with an antiproliferative effect on keratonocytes, e.g. manganese, and at least one substance that blocks tumour necrosis factor-alpha (TNF-α) or other cytokines that provoke the acute phase of the inflammatory reaction, also with an antiproliferative effect, e.g. pentoxifylline.

The invention relates to the technical field of biology, and discloses a coenzyme-Q10-production engineered bacteria construction method, engineered bacteria, and an application thereof. The method comprises the steps that: a, total genomic DNA is extracted from Rhodobacter sphaeroides cacterial liquid; b, UbiG gene is obtained by amplification with a polymerase chain reaction; c, the amplified UbiG gene is connected with broad-host plasmid, such that recombinant vector is constructed; d, the recombinant vector is transferred to Escherichia coli S17-1; and e, the Escherichia coli S17-1 is subjected to conjugal transfer with the Rhodobacter sphaeroides, such that the engineered bacteria are obtained. According to the method provided by the invention for improving coenzyme Q10 yield through regulating Rhodobacter sphaeroides aromatic ring modification pathway, the operation is simple, and coenzyme Q10 synthesis capacity can be improved by higher than 30%. The method is suitable for coenzyme Q10 large-scale industrial production.

The invention relates to a coenzyme Q10 combination and a preparation method thereof and provides a water-soluble coenzyme Q10 combination, which contains the following raw materials in parts by weight: 5-15 parts of coenzyme Q10, 10-120 parts of water-soluble carrier and 0.5-40 parts of emulsifier; the water-soluble carrier is one or more of maltodextrin, CMC, purity gum, soluble starch, lactose, fructose, sorbierite, mannite, Arabic gum, carrageenan, microcrystalline cellulose and sodium carboxymethyl starch; and the emulsifier is non-ionic surfactant. The invention also provides the preparation method of the water-soluble coenzyme Q10 combination. Fat-soluble coenzyme Q10, the water-soluble carrier and the amphoteric emulsifier are mixed and prepared into the water-soluble coenzyme Q10 combination, and the method synthesizes the advantages of an inclusion technique and a solid dispersion technique and solves the problems that the fat-soluble coenzyme Q10 is difficult to dissolve in water and has low bioavailability, and a number of experiments prove that the water-soluble coenzyme Q10 combination has good water solubility, fast dissolution rate, good stability and high content of effective substances.