314 results about "Coenzyme Q10" patented technology

The invention discloses an ovarian protection composition containing ergothioneine and a preparation method of the ovarian protection composition, and relates to the technical field of ovarian protection compositions. The ovary protection composition containing the ergothioneine is prepared from the following components in parts by mass: 0.1 to 0.5 part of the ergothioneine, 0.05 to 1 part of S-equol, 1 to 5 parts of reducing coenzyme Q10, 1 to 3 parts of vitamin E, 10 to 20 parts of chitosan oligosaccharide, 30 to 50 parts of microcrystalline cellulose, 3 to 8 parts of hydroxypropyl methyl cellulose, 0.5 to 2 parts of silicon dioxide and 0.5 to 2 parts of a stabilizer. By adopting the stabilizer, photooxidation and hydrolysis of sensitive components are inhibited through molecular action, and the long-term stability of the composition in a humid and hot environment is remarkably improved in combination with the physical barrier action of silicon dioxide. Through the antioxidant synergistic effect of the ergothioneine and the vitamin E, the hormone regulation effect of the S-equol and the energy metabolism improvement effect of the coenzyme Q10, a multi-layer ovarian function protection system is constructed, and the health state of ovaries is improved. Through a special process, the tablet can be rapidly disintegrated and slowly released in an intestinal targeted manner, burst release of active ingredients is avoided, and the absorption efficiency is improved.

The invention discloses a coenzyme Q10 soft capsule appearance defect detection method based on image recognition, relates to the technical field of capsule detection, and solves the problem that the reliability and pertinence of a detection result are insufficient due to the fact that different types of defects such as size deviation and breakage wrinkles cannot be effectively recognized. According to the method, the standard image and the to-be-analyzed image set are determined from a large number of images, and then the image with the most significant difference between the to-be-analyzed features and the focus is selected for ellipse perimeter comparison; according to the mode, the analysis range can be efficiently narrowed, the area where wrinkles, damage or abnormal sizes possibly exist can be accurately positioned, and the pertinence and efficiency of defect analysis are improved.

The invention discloses an endogenous anti-aging composition based on an internal and external synergistic mechanism and a preparation method of the endogenous anti-aging composition. The endogenous anti-aging composition based on the internal and external synergistic mechanism is prepared from the following components in parts by mass: 100 to 200 parts of alpha-ketoglutarate calcium; 100 to 200 parts of an olive leaf extract; 10 to 20 parts of nicotinic acid; 10 to 20 parts of pyrroloquinoline quinone; 20 to 60 parts of pomegranate extract; and 10 to 30 parts of coenzyme Q10. The composition and the preparation method thereof have the beneficial effects that the composition capable of integrally improving the aging state of women from multiple dimensions and the preparation method of the composition are provided.

The invention discloses an oral instant film suitable for pet nutrition intervention and a preparation method of the oral instant film, and belongs to the technical field of pet oral preparations. The instant film adopts a sandwich type multi-layer structural design, sequentially comprises a first food calling layer, a core layer and a second food calling layer, can be selectively provided with a functional layer and an interface middle layer, and constructs a staggered hot-pressing laminated structure, so that the structural stability and the function delivery efficiency of a film body are remarkably improved. The core layer contains multiple composite active ingredients such as L-carnitine, coenzyme Q10, beta-glucan, glucosamine sulfate and the like, chitosan-inulin-polyglutamic acid or starch is adopted for embedding to form a first microcapsule and a second microcapsule, and intelligent delivery of temperature / pH response and gastrointestinal controlled release is achieved. The food calling layer is composed of chicken powder, fish oil powder, fructo-oligosaccharide and the like, and the feeding compliance of pets is improved.

The invention discloses a composition containing D-chiro-inositol as well as a preparation method and application of the composition. The composition comprises D-chiro-inositol, Myo-inositol and microcapsule powder, wherein the wall material of the microcapsule powder consists of anhydride modified edible protein and a polysaccharide compound; the edible protein is selected from at least one of spirulina protein, quinoa protein, whey protein and soybean protein; the polysaccharide compound comprises at least one of fucoidin and larch arabinogalactan. Active components are also embedded in the microcapsule powder, and comprise at least one of Omega-3, coenzyme Q10, astaxanthin and vitamin. According to the composition, the stability and bioavailability of fat-soluble active ingredients are improved through microencapsulation, and the composition has a synergistic effect with components such as D-chiro-inositol and Myoinositol, so that insulin resistance is effectively improved, female hormone balance is adjusted, and polycystic ovarian syndrome is improved. The process is simple, is suitable for large-scale production, and can be widely applied to dietary supplements or functional foods.

The invention provides a reduced coenzyme Q10 eutectic crystal as well as a preparation method and application thereof. The eutectic crystal is prepared from the reduced coenzyme Q10 and L-lysine. Compared with the prior art, the prepared reduced coenzyme Q10 eutectic can effectively improve the stability of the reduced coenzyme Q10, and widens the solid existence form of the reduced coenzyme Q10. The preparation method of the reduced coenzyme Q10 eutectic crystal provided by the invention is simple, low in cost, convenient for large-scale production and favorable for subsequent product development, and particularly has important value for developing a reduced coenzyme Q10 solid oral preparation in the future.

The invention relates to the technical field of biologic stimulant preparation, and discloses a biologic stimulant mixing preparation two-stage control method, which comprises: adopting dissolved oxygen gradient and carbon source pulse cooperative control, linearly reducing the concentration of dissolved oxygen in a fermentation tank from an initial value at a specific rate, and injecting a carbon source at regular time; when the flora density and the quorum sensing signal molecule concentration reach specific threshold values, triggering stage switching; starting pressure-metabolism coupling control, increasing the pressure of the fermentation tank at a specific rate, and adding coenzyme Q10; the quorum sensing inhibitory peptide containing a specific core structure is synchronously released in the boosting process; after the pressure is stable, a real-time mapping relation between a microbial metabolism state and physical parameters is constructed in a thallus proliferation stage through a coupling mechanism of dissolved oxygen gradient control and quorum sensing signal monitoring, and the industrial problem that a traditional static threshold value cannot respond to pressure fluctuation of a fermentation tank to cause signal attenuation is solved.

The invention provides a reduced coenzyme Q10 and gamma-aminobutyric acid eutectic crystal and a preparation method and application thereof, and belongs to the technical field of eutectic crystal manufacturing. In the eutectic crystal, the molar ratio of the reduced coenzyme Q10 to the gamma-aminobutyric acid is 1: 2, and the structural formula of the eutectic crystal is as shown in formula I. The eutectic crystal has the advantages of good stability, low cytotoxicity and strong oxidation resistance.

The invention belongs to the technical field of cosmetics, and particularly relates to a silk fibroin aggregate-based dispersed organic active substance as well as a preparation method and application thereof. The preparation method of the silk fibroin aggregate-based dispersed organic active substance comprises the following steps: (1) dissolving an organic active substance in a first solvent to obtain a first solution; dissolving the silk fibroin aggregate in a second solvent to obtain a second solution; (2) slowly adding the second solution into the first solution, mixing and homogenizing to obtain a silk fibroin aggregate-based dispersed organic active substance; wherein the silk fibroin aggregate is prepared by mixing a silk fibroin aqueous solution and alcohol. The silk fibroin aggregate-based dispersed organic active substance prepared by the preparation method can improve the bioavailability of the organic active substance (such as vitamin C, hyaluronic acid, coenzyme Q10, nicotinamide, arbutin, kojic acid, licorice extract, centella extract, chamomile extract or green tea extract) in cosmetics.

The present invention relates to the technical field of dietary supplements, and more particularly to a composition formulation having an NMN anti-aging effect and a preparation method thereof. Technical Problem: the composition formulation having an NMN anti-aging effect and the preparation method thereof aim to solve the technical problem of not being able to enhance the body's resistance while also having an anti-aging effect, making the patient's body more energetic. Technical Solution: a composition formulation having an NMN anti-aging effect, including the following components: NMN 300 mg, PQQ 10 mg, coenzyme Q10 20 mg, ginsenoside 70 mg, aminobutyric acid 100 mg, other beneficial ingredients q. s.

The invention relates to a multi-enzyme synergistic skin care composition suitable for sensitive skin and application thereof, the skin care composition comprises the following components: crithmum maritimum extract, pomegranate peel extract, lysozyme and coenzyme Q10, the crithmum maritimum extract is obtained by anaerobic fermentation of crithmum maritimum through leuconostoc mesenteroides and lactobacillus plantarum and is rich in SOD enzyme; the pomegranate peel extract is obtained by performing anaerobic fermentation on pomegranate fruits through lactobacillus helveticus and is rich in protease and lipase. The crithmum maritimum extract, the pomegranate peel extract, the lysozyme and the coenzyme Q10 are compounded for use, a multi-dimensional synergistic skin care system is constructed, and repairing, anti-inflammatory and anti-aging integrated efficient improvement is achieved.

The invention provides methods and compositions for treatment of a subject with a glioma. The methods comprise administering a composition comprising Coenzyme Q10 to the subject by continuous intravenous infusion; and administering radiation therapy to the subject. The composition comprising Coenzyme Q10 may be administered to the subject by continuous intravenous infusion for at least 24 hours before the radiation therapy is initiated.

The invention relates to an anti-aging capsule compounded by PQQ and mitochondrial nutrients, and discloses an anti-aging capsule which is prepared by synergistically compounding a plurality of mitochondrial nutrients according to a scientific proportion and supplementing high-purity raw materials and slow-release dosage forms to realize energy metabolism activation and anti-oxidation synergistic intervention. Therefore, the anti-aging capsule systematically delays aging through multi-target regulation and control of mitochondrial functions. The capsule is characterized by comprising the following components in parts by weight: 1-20 mg of pyrroloquinoline quinone disodium salt (PQQ), 20-100 mg of coenzyme Q10, 50-200 mg of L-carnitine tartrate, 10-100 mg of alpha-lipoic acid, 50-300 mg of nicotinamide mononucleotide (NMN) or nicotinamide nucleoside (NR), and 10-50 [mu] g of selenoprotein or organic selenium yeast, and a capsule carrier comprises 100 mg of gelatin or a plant-derived capsule shell, 180 mg of microcrystalline cellulose, 5 mg of magnesium stearate and 5 mg of silicon dioxide.

The invention relates to the technical field of health food, in particular to a nervonic acid nutrient composition for relieving sleep disorder and application of the nervonic acid nutrient composition for relieving sleep disorder. The active components comprise natural vegetable oil such as acer truncatum seed oil purified nervonic acid, linseed oil and the like and gamma-aminobutyric acid extracted by fermentation; the synergistic component is prepared from soybean enzymolysis phosphatidylserine, saccharomycetes fermentation coenzyme Q10 and plant source B vitamins; the slow-release carrier adopts pectin-Arabic gum composite gel and plant starch to form a natural cross-linked structure, and long-acting release for 8-12 hours is realized through physical cross-linking. Green technologies such as ultrasonic dispersion and low-temperature drying are adopted in the preparation process, and chemical synthesis steps are avoided; the composition can improve the difficulty in falling asleep and improve the sleep quality, the activity retention rate is greater than or equal to 85% after the composition is stored at 45 DEG C for 6 months, and the composition is suitable for preparing capsules, gel candies and other health-care foods and has no dependence after being taken for a long time.

The invention discloses a composition containing NMN and a preparation method and application thereof. The composition provided by the invention comprises any two or more of NMN, coenzyme Q10, pyrroloquinoline quinone, resveratrol, plant fiber and glutathione. The invention unexpectedly discovers that the combination of two or more of NMN, coenzyme Q10, pyrroloquinoline quinone, resveratrol, plant fiber, glutathione and gamma-butylamine shows a beneficial synergistic effect in improving the NAD + level in vivo compared with a single component only applying pure NMN. Moreover, this synergy may result in additional benefits in therapy, such as anti-aging, enhancing immunity, resisting oxidation, protecting nerves, improving sub-health status, improving patient compliance, and the like. Meanwhile, no side effect is generated after long-term taking, and the conditions of body tolerance, drug effect absorption reduction and the like caused by long-term taking are also avoided.

This invention discloses a cardioprotective compound composition and its preparation based on improving the absorption rate of coenzyme Q10, relating to the fields of pharmaceuticals and functional foods. The core active ingredients of this composition consist of coenzyme Q10, vitamin E, and black pepper extract, with a specific mass ratio range for each. It can also be combined with pharmaceutically acceptable carriers and antioxidant synergists to prepare various oral formulations. This invention, through the construction of a ternary active component with a specific ratio, achieves in vivo synergistic effects on absorption promotion and antioxidant regeneration, solving the technical problems of low oral bioavailability and insufficient accumulation of myocardial-targeted activity in existing coenzyme Q10 preparations. It significantly improves the conversion efficiency of coenzyme Q10 into a usable active form for cardiomyocytes and can be widely applied in the preparation of drugs and functional foods for the prevention or treatment of heart diseases.

The invention discloses a functional additive composition for animal food. The functional additive composition is prepared from coenzyme Q10, glutamic acid, galactooligosaccharide, fructus lycii powder and the balance of food-grade carrier. The components of the composition cooperate with each other, so that the composition can support the effects of enhancing the physique vitality of animals, promoting nutrient absorption, helping to maintain a healthy intestinal environment and the like, has remarkable innovativeness and practicability, and is expected to create good benefits in the field of animal foods. The invention can be used in economic animals and pet animals.

The invention discloses an anti-inflammatory and anti-aging body lotion and a preparation method thereof, and relates to the technical field of skin care products. The preparation method comprises the following steps: firstly, carrying out oxidation treatment on beta-cyclodextrin by using sodium periodate, and introducing an active aldehyde group on a glucose unit of the beta-cyclodextrin, so as to form aldehyde beta-cyclodextrin with a unique function; the cavity structure of the beta-cyclodextrin has efficient embedding capacity, and the hydrophobic coenzyme Q10 can be tightly wrapped in the beta-cyclodextrin; the preparation method comprises the following steps: grafting adipic acid dihydrazide onto a hyaluronic acid skeleton to form hydrazinized hyaluronic acid with reaction activity; the hyaluronic acid is subjected to specific cross-linking reaction with aldehyde beta-cyclodextrin through hydrazino on the surface of the hyaluronic acid, a micro-capsule structure with a dynamic covalent bond-hydrazone bond is formed, a three-stage delivery mode of stable storage, intelligent release and accurate action is formed, active ingredients can be effectively protected, intelligent release can be achieved according to the pH value characteristic of skin, and the skin care effect is achieved. The inflammatory reaction is relieved, and the anti-inflammatory and anti-aging effects are achieved. The body lotion prepared by the invention has anti-inflammatory and anti-aging effects.

The present invention relates to a liquid-phase, supplementary feed composition containing coenzyme Q10 and, more specifically, to a liquid-phase, supplementary feed composition containing coenzyme Q10, conjugated linoleic acid, fructooligosaccharide, L-carnitine, and taurine at specific contents, whereby the composition can prevent aging and onset of cardiovascular diseases and cardiac disease, activate the immune system, and provide a diet effect in companion animals.

The application provides a coenzyme Q10-producing genetically engineered bacterium and application thereof.

The utility model relates to the technical field of coenzyme Q10 particle storage, and discloses a coenzyme Q10 storage tank convenient to take out, which comprises a tank body, an inner box is arranged in the tank body, the top end of the inner box is fixedly connected with a cover plate, the inner wall of the inner box is movably connected with a supporting plate, and the upper surface of the supporting plate is provided with discharge holes at equal intervals. According to the coenzyme Q10 particle taking-out device, due to the fact that the positioning column is arranged, when the coenzyme Q10 particle taking-out device is taken out, the shifting block is pulled upwards firstly, the cover plate drives the inner box to move upwards, at the moment, coenzyme Q10 particles in the inner box can move to the top end of the positioning column, and then the coenzyme Q10 particles are taken out; when the inner box is in use, clamping grooves in the top ends of the positioning columns can lift the coenzyme Q10 particles, when the inner box is reset, the coenzyme Q10 particles at the top ends of the positioning columns can move into medicine outlet holes in the upper surface of the cover plate, at the moment, a sliding block slides to drive a sealing cover to move away from the medicine outlet holes, and therefore the coenzyme Q10 particles are taken out.

The invention relates to the technical field of semen preservative preparation, in particular to a diluent preparation capable of prolonging the normal-temperature survival time of boar semen and a preparation method of the diluent preparation. Glucose, L-glutamine, an antioxidant and polysaccharide components are scientifically proportioned, and an innovative polyethyleneimine-polysaccharide copolymer is combined, so that the normal-temperature survival time of boar semen is prolonged; the dual effects of sperm metabolism regulation and cell membrane protection are realized. The polyethyleneimine-polysaccharide copolymer enhances the biocompatibility and protective ability of the diluent through stable cross-linking of amino and carboxyl, and effectively relieves the problem of sudden change of osmotic pressure and acidity of the traditional preservative. In the formula, antioxidant components, such as reduced glutathione, vitamin E and coenzyme Q10, synergistically reduce oxidative stress and delay sperm senescence. According to the whole formula, proper pH and osmotic pressure are guaranteed, the sperm motility and survival time are remarkably prolonged, the requirement of pig industry for long-term preservation of sperm is met, and the feed additive has remarkable application value and popularization potential.

The invention relates to the technical field of coenzyme Q10 preparations, and discloses a coenzyme Q10 preparation for improving myocardial cell activity and cardiovascular function, and the coenzyme Q10 preparation comprises the following components in percentage by mass according to 1 liter of prescription: 0.1-10% of coenzyme Q10, 0.5-30% of emulsifier, 5-20% of co-emulsifier, 0.5-10% of stabilizer, 5% of glucose, 0.9% of sodium chloride, 0.25% of absolute ethyl alcohol and the balance of water, according to the coenzyme Q10 preparation for improving the myocardial cell activity and the cardiovascular function, preparation of the coenzyme Q10 preparation is completed, so that the obtained coenzyme Q10 preparation has the functions of enhancing physical ability and vigor, protecting the cardiovascular system, reducing side effects of lipid-lowering drugs, protecting the skin and the like, and the coenzyme Q10 preparation can improve the myocardial function and improve cardiovascular diseases; the heart is prevented from being damaged by oxidative stress.

The invention provides a metabolic engineering transformation method of high-yield coenzyme Q10 of rhodobacter sphaeroides and application of transformed engineering bacteria. The method comprises the following steps: knocking out geranyl and geranyl pyrophosphate synthase gene crtE participating in a carotenoid synthesis route; performing overexpression on a farnesyl pyrophosphate synthase gene ispA; a histidine kinase coding gene prrB is mutated, and the mutant is introduced. According to the invention, a combined regulation strategy suitable for targeted regulation is found, the metabolic flux synthesized by the coenzyme Q10 is accurately optimized, and the capability of producing the coenzyme Q10 by the rhodobacter sphaeroides is greatly improved.

The present invention belongs to the field of extraction of microbial phospholipids, and specifically discloses a method for efficiently purifying phospholipids from coenzyme Q10 fermentation powder, which comprises the following steps: 1) mother liquor culture, 2) seed tank culture, 3) fermenter culture, 4) centrifugation of fermentation broth, 5) high-pressure homogenization, 6) centrifugation of cell lysate, 7) vacuum freeze-drying, 8) subcritical extraction, 9) acetone extraction, 10) rotary evaporation; by adjusting the medium components and optimizing the culture process, the present invention can achieve high-density culture of Agrobacterium tumefaciens cells, obtain a large amount of cells, in the fermentation broth, the coenzyme Q10 content can reach 5.1 g / L of fermentation broth, and the phospholipid content can reach 13.5 g / L of fermentation broth. Moreover, the present method also discloses a separation and purification method for efficiently extracting high-purity phospholipids from coenzyme Q10 fermentation powder, turning waste into treasure, with good economic benefits, and the steps are simple and mild, with low requirements for equipment, and are environmentally friendly.

The invention discloses a slow-release coenzyme Q10 liposome and a preparation method thereof. The liposome comprises a coenzyme Q10 core material and a double-layer wall material, the double-layer wall material comprises an inner-layer wall material and an outer-layer composite wall material; the inner-layer wall material is prepared from at least one of hydroxypropyl methyl cellulose, pectin, gelatin and xanthan gum; the outer-layer composite wall material is a combination of modified soybean phospholipid and a first wall material; the first wall material is selected from at least one of the following materials: maltodextrin, starch sodium octenylsuccinate, Arabic gum and cyclodextrin. The coenzyme Q10 lipidosome with high content and high stability is prepared by adopting a double-layer inclusion technology and a lipidosome technology, the content of the lipidosome coenzyme Q10 can reach up to 50%, and the lipidosome has good dispersion performance in water, has continuous oxidation resistance, and can effectively neutralize free radicals and relieve oxidative stress. The effective release and retention of the coenzyme Q10 under the condition of simulating intestinal tracts can be maintained, and the stability and the bioavailability of the CoQ10 are enhanced.

The invention discloses a smearing type mask and a preparation method thereof, and belongs to the technical field of cosmetics. The smearing type mask is prepared from coenzyme Q10 lipidosome, tetrahydrocurcumin lipidosome, lotus flower extract, citrus peel extract, a humectant, grease, an emulsifier, an excipient, a skin conditioner, a pH regulator and water. The invention further provides a preparation method of the smearing type mask. The preparation method comprises the following steps: heating the component A to 80-85 DEG C, and preserving heat; heating the component B to 80-85 DEG C, keeping the temperature, and then mixing, homogenizing and emulsifying the component A and the component B; then stirring and cooling to 65-75 DEG C, then adding the component C and the component D in sequence, and stirring and homogenizing; cooling to 40-45 DEG C, and continuously adding the component E, the component F and the component G; and continuing to add the component H, then adding the component I, stirring and homogenizing to obtain the smearing type mask. The mask provided by the invention has the use effects of moisturizing, tightening, resisting wrinkles and brightening.

The invention relates to an oral cavity deodorization composition containing coenzyme Q10 and application of the oral cavity deodorization composition. The oral cavity deodorization composition is prepared from the following components: coenzyme Q10, fructus piperis longi extract, tribulus terrestris extract and centipeda minima extract. The oral cavity deodorization composition containing the coenzyme Q10, provided by the invention, is safe and healthy through the matching of the components, can exert an oral cavity deodorization function to the greatest extent, and also has certain anti-inflammatory and antibacterial effects. The oral cavity deodorization composition containing the coenzyme Q10 is simple in preparation process, low in cost and safe and stable in effect, and the prepared product is free of toxic and side effects.

The invention relates to the field of preparation of veterinary coenzyme Q10 preparations, in particular to a veterinary coenzyme Q10 composite emulsion as well as a preparation method and application thereof. The veterinary coenzyme Q10 composite emulsion is prepared by utilizing a nanostructure lipid carrier system and supplementing vitamins A, D and E, and the preparation method of the veterinary coenzyme Q10 composite emulsion is simple. The veterinary coenzyme Q10 composite emulsion is small in particle size, low in polydispersity coefficient, good in zeta potential absolute value and stability, high in uniformity and high in coenzyme Q10 concentration. Meanwhile, the coenzyme Q10 is high in administration efficiency and small in side effect, can realize drinking administration of the coenzyme Q10, is suitable for oral administration of animals, meets the administration requirements of veterinary clinical breeding enterprises, and has a wide application prospect.

The invention relates to the technical field of medicine storage, and discloses an AI-based coenzyme Q10 soft capsule dynamic storage environment control system, which comprises a data acquisition module used for acquiring temperature data, humidity data, illumination intensity data and medicine state data; the data preprocessing module is used for cleaning the collected data, removing abnormal values and noise data, and performing normalization processing to obtain preprocessed data; the model prediction module is used for inputting the preprocessed data into an LSTM (Long Short Term Memory) model, predicting the change trend of environmental parameters in a future time window, simulating a degradation path of the activity of the coenzyme Q10 and outputting a prediction result; the environment regulation and control module is used for generating a control strategy according to the prediction result and realizing dynamic adjustment of environment parameters through an execution mechanism; according to the invention, the dynamic and accurate regulation and control of the storage environment are realized, the manual intervention is reduced, the labor cost is reduced, and the overall efficiency of storage management is improved.