The invention relates to a creatine phosphate sodium freeze-dried preparation and a method for preparing the same. The mass ratio of creatine phosphate sodium to an excipient in the creatine phosphate sodium freeze-dried preparation is 1: 0.05 to 1: 20. The method for preparing the creatine phosphate sodium freeze-dried preparation comprises the steps of: adding active carbon to a solution containing the creatine phosphate sodium and the excipient, stirring, removing pyrogen, then filtering, decarburizing, filtering again, degerming, and packing filtrate in a split charging manner to obtain the creatine phosphate sodium freeze-dried preparation after freeze drying. The preparation, indicated by solubility tests, influencing factor tests, accelerating tests and long term stability tests, has the advantages of quick solution velocity and good stability, compared with the conventional creatine phosphate sodium powdery preparation. In addition, the freeze-dried preparation is produced in a relatively closed environment and the security of products is more reliable.