41results about "Hydrazide preparation" patented technology

The application discloses a continuous synthesis method of an amicarbazone intermediate 5-isopropyl-1,3,4-oxadiazole-2(3H)-ketone. The method comprises two continuous processes of hydrazinolysis and phosgenation: continuously feeding a mixture of isobutyric acid and a solvent, a mixture of hydrazine hydrate and a catalyst into a hydrazinolysis continuous reactor respectively, carrying out a warming reflux dehydration reaction, and obtaining an isobutyryl hydrazine solution shown in formula I; continuously feeding the isobutyryl hydrazine solution and phosgene into a phosgenation continuous reactor, carrying out a phosgenation reaction, and after distillation and desolventizing treatment of a reaction solution, obtaining 5-isopropyl-1,3,4-oxadiazole-2(3H)-ketone shown in formula II. The application has the advantages of simple reaction flow, high product yield, and significant production efficiency improvement, and is suitable for industrial large-scale production.

A preparation method of N '-((2S, 3S)-2-(benzyloxy) pent-3-yl) formylhydrazine oxalate enzyme belongs to the field of medical intermediates, and comprises the following steps: step 1, preparing a buffer solution of a compound enzyme preparation; step 2, adding (2S)-2-benzyloxy-3-pentanone into a solvent A, and then adding a buffer solution of the compound enzyme preparation for reaction; 3, filtering, and carrying out an activation reaction on the filtrate; 4, filtering, removing the solvent, adding the obtained solid into a solvent B, and then adding formylhydrazine for reaction; 5, filtering, removing the solvent, adding the obtained solid into a solvent C, and then adding oxalic acid for reaction; and 6, drying the solid obtained by filtering to obtain the N '-((2S, 3S)-2-(benzyloxy) pent-3-yl) formylhydrazine oxalate. According to the method, the yield of the N '-((2S, 3S)-2-(benzyloxy) pent-3-yl) formylhydrazine oxalate can be increased, and the production cost is effectively reduced.

Object of the present invention is an improved process for the preparation of Indomethacin of formula (I): by means of the precipitation, crystallization, re-crystallization or re-slurry of the intermediate 4-chloro-N-(4-methoxyphenyl)benzohydrazide in a mixture comprising tetrahydrofuran and a C1-C4 linear or branched alkyl alcohol.

A method for preparing the insecticide N-(1-methylcyclopropyl)-2-(3-pyridinyl)-2H-indazole 4-carboxamide is disclosed. A method for preparing the intermediate N-(1-methylcyclopropyl)-2-(3-pyridinyl)-2H-indazole 4-carboxamide is also disclosed.

The application belongs to the technical field of chemical production, and particularly relates to a preparation method and a preparation device of adipic acid dihydrazide. The preparation method of the adipic acid dihydrazide comprises the following steps: S1, treating raw materials; S2, adding the raw materials into a reaction tank for reaction; S3, cooling and crystallizing; S4, washing the crystals and purifying; and S5, drying and packaging the purified crystals. In the process of the reaction of the raw materials in the reaction tank, the raw materials are fully mixed by a mixing mechanism arranged in the reaction tank. The mixing mechanism pushes the mixed solution in the upper layer downward and pushes the mixed solution in the lower layer upward, so that the mixed solution flows in the axial direction, the mixed solution in the middle layer is subjected to turbulent flow, the mixed solution is more uniformly mixed, and the mixing effect is improved.

This invention relates to the field of pharmaceutical impurity preparation technology, and discloses a method for synthesizing apixaban genotoxic impurity I. The steps include: S1. performing an addition reaction of compound II in an alkaline system to generate compound III; S2. subjecting the product of S1 to elimination and isomerization reactions under heating, separating the reaction product to obtain apixaban genotoxic impurity I. The synthesis method of this invention has high safety, low raw material cost, and can achieve a one-pot reaction while ensuring yield and product purity (no product separation and purification is required between each reaction step; only one separation and purification is needed after obtaining the final product).

The invention provides an ADH-free heat-yellowing-resistant agent without formaldehyde adsorption and a preparation method thereof, and belongs to the technical field of heat-yellowing-resistant agents. According to the invention, alkyl diacid dihydrazide and organic acid are used as raw materials, carboxyl and hydrazide are acetylated to close active amido and block the combination path of the active amido and formaldehyde, so that the problem that the fabric adsorbs formaldehyde after being finished with a heat-resistant yellowing agent is solved, and meanwhile, the strong reducibility of the hydrazide structure is retained; the yellowing value of the fabric in the heat setting or ironing process is obviously reduced. The thermal yellowing resistant agent has a neutral structural unit with thermal stability, and the structural unit is not easy to decompose at high temperature and can effectively block the oxidative degradation path of nylon. The preparation process of the heat-yellowing-resistant agent does not need to use an organic solvent, the heat-yellowing-resistant agent can be prepared only through one-step reaction, the preparation process is simple, and the cost is low.

This application discloses a method for synthesizing adipic acid dihydrazide, belonging to the field of organic synthesis technology. The method involves adding adipic acid, an alcohol solution, and a strongly acidic cation exchange resin catalyst to a reaction vessel for esterification to obtain adipic acid dialkyl ester. The adipic acid dialkyl ester, a co-catalyst, and hydrazine hydrate are then subjected to a hydrazolysis reaction in a three-stage temperature-controlled process to obtain the final product, adipic acid dihydrazide. The co-catalyst system significantly reduces the activation energy of the hydrazolysis reaction, and the amount of hydrazine hydrate used is greatly reduced. The high efficiency conversion and low addition amount of hydrazine hydrate result in a significant reduction in the free hydrazine content of the product, making the process simpler, more energy-efficient, and environmentally friendly. The three-stage temperature control, from low-temperature induction nucleation to the medium-temperature main reaction and then to high-temperature completion, balances reaction selectivity and conversion rate, avoiding side reaction problems caused by insufficient zone control under isothermal reaction conditions. The catalyst is widely available and cost-controllable, and the process conditions are mild, making it suitable for industrial production.

The benzyl hydrazine derivative has the advantages of being good in activity and novel in structure, the benzyl hydrazine derivative serves as an RIPK1 small-molecule inhibitor, necroptosis induced by TNF-alpha can be reduced, and therefore the anti-inflammatory effect is achieved, and the benzyl hydrazine derivative can be used for preparing drugs for treating inflammation-related diseases such as diabetic nephropathy.

The invention discloses an aryl bishydrazide compound with a structural formula shown in the following formula: in-vitro experiment results show that the compound has remarkable inhibitory activity on dengue virus (DENV), the therapeutic index (TI) of the compound is remarkably higher than that of a clinical positive control drug ribavirin, and in addition, the compound can be used for preparing an aryl bishydrazide compound with the structural formula shown in the specification. The preparation method disclosed by the invention is simple and efficient in process, good in yield and mild in reaction condition, has good large-scale production potential, and provides a feasible synthesis basis for further clinical transformation and application.

The application belongs to the technical field of biodegradable polyester nucleating agent synthesis, and discloses a small-molecule hydrazide nucleating agent for improving the crystallization ability of polylactic acid, and a preparation method and application thereof.A novel polylactic acid nucleating agent designed and synthesized by the application is prepared by adding terephthaloyl chloride, methoxybenzoyl hydrazine and a bundling agent into a solvent and synthesizing at 60 DEG C.The nucleating agent is mixed with polylactic acid by a melt blending method, and is extruded or injection molded into a polylactic acid product, so that good nucleation efficiency is provided for polylactic acid during preparation, the nucleation effect is stable, the polylactic acid product obtained has a high crystallization peak temperature, excellent mechanical properties and other characteristics.The preparation method of the nucleating agent is simple, mass production can be realized, and the nucleating agent can be widely applied to the preparation of industrial polylactic acid plastic products.

The invention discloses a high-enthalpy-value metal-organic coordination material as well as preparation and application thereof, and belongs to the field of phase change energy storage. According to the metal-organic coordination material, transition metal nitrate is coordinated with acethydrazide in a small molecule amide ligand to obtain a series of metal-organic coordination materials. The material realizes the synergistic effect of a hydrogen bond network and a metal coordination bond, so that the material has the advantages of high phase change temperature, large enthalpy value and the like. Compared with a traditional phase change material, the phase change material has excellent thermodynamic property and thermal stability. The device can be applied to the field of heat management of high-power equipment, has the advantages of high energy storage density, low material consumption and the like, and has wide application prospects.

The present application relates to the field of gas separation and purification, and discloses a composition with acid gas absorption function.The composition comprises an absorbent and an additive; wherein the absorbent comprises at least one of an organic amine, a polyether and a C7-C10 fatty alcohol; and the additive is a compound with demulsification function.The composition has good purification and separation effect, is strong in industrial application and operability, can regenerate more adsorbed gas (such as carbon dioxide) per unit time, effectively reduces the energy consumption required for regenerating unit adsorbed gas, and can provide strong guarantee for application of the absorbent to gas removal and realization of continuous absorption and regeneration industrialization device.

The invention relates to the technical field of organic synthetic chemistry, in particular to 1-{2-[3-(4-hydroxyphenyl) propionyl] diazo alkyl} docosan-1-ketone as well as application and a preparation method of 1-{2-[3-(4-hydroxyphenyl) propionyl] diazo alkyl} docosan-1-ketone. According to the method, docosanoic acid and 3-(4-hydroxyphenyl) propanohydrazide are used as raw materials, and in a polar aprotic solvent, a benzotriazole coupling reagent and organic base are adopted for catalysis and a coupling reaction is carried out. According to the method, one-step coupling without protecting groups can be realized, the synthesis efficiency is remarkably improved, and the production cost is reduced; the method also has the advantages of mild conditions, high yield, excellent product purity, safety, environmental protection, suitability for large-scale popularization and the like.

One aspect of the present invention aims to provide a moisture-curing hot-melt adhesive whose peel strength is easily reduced by an oxidizing agent. Another aspect of the present invention aims to provide a urethane resin suitably used in the adhesive, and a novel method for producing a hydrazide compound suitably used as a raw material for the urethane resin. [Solution] The following formula (1): [Formula 1] TIFF2026521010000013.tif35103 (in the formula, R 1 and R 2 (Each of these independently represents an alkylene group, and m and n independently represent integers greater than or equal to 2.) A method for producing a hydrazide compound represented by formula (1), comprising the step of obtaining the hydrazide compound represented by formula (1) by causing a ring-opening reaction between hydrazine and lactone.

The invention provides a compound and a preparation method thereof as well as a covalent organic framework material and application thereof, and relates to the technical field of uranium extraction adsorption materials, the preparation method of the NH4 < + > modified covalent organic framework material comprises the following steps: uniformly mixing trialdehyde phloroglucinol, a compound as shown in a formula I, 1, 4-dioxane, mesitylene and acetic acid to obtain a first mixed solution; removing dissolved gas from the first mixed solution to obtain a second mixed solution; carrying out condensation reaction on the second mixed solution at 110-120 DEG C to obtain a covalent organic framework material; and mixing the covalent organic framework material with an NH4Cl solution for reaction to obtain the NH4 < + > modified covalent organic framework material. The NH4 < + > modified covalent organic framework material contains rich hydroxyl groups and NH4 < + >, provides a large number of adsorption sites for [UO2 (CO3) 3] < 4-> in the presence of the NH4 < + > modified covalent organic framework material, and can rapidly capture [UO2 (CO3) 3] < 4->, so that efficient uranium extraction is realized.

The utility model relates to the technical field of carbazide production, in particular to a production system for refining carbazide, which comprises a first dissolving kettle, a discharge port of the first dissolving kettle is communicated with a first adsorption device, a discharge port of the first adsorption device is communicated with a first crystallization kettle, and a crystal outlet of the first crystallization kettle is communicated with a second dissolving kettle. A discharge port of the second dissolving kettle is communicated with a second adsorption device, a discharge port of the second adsorption device is communicated with a second crystallization kettle, a crystal outlet of the second crystallization kettle is communicated with a washing tank, a discharge port of the washing tank is communicated with a drying device, and a discharge port of the drying device is communicated with a product storage tank. The production system is reasonable in design, and the purity of carbazide is greatly improved.

The present application relates to the technical field of pharmaceutical chemistry, and particularly relates to an alpha, beta-unsaturated amide or hydrazide compound containing a carbonyl structure, a preparation method and application. The present application mainly prepares the alpha, beta-unsaturated amide or hydrazide compound containing a carbonyl structure. The compound has a novel structure, and has a good inhibitory effect on plant pathogenic fungi, and particularly has a good inhibitory effect on plant pathogenic fungi such as grape colletotrichum, rice sheath blight, brassica sclerotinia, wheat scab, tomato early blight, tobacco brown spot and eggplant fusarium wilt. The compound has outstanding advantages in the prevention and treatment of plant fungal diseases.

A continuous process for preparing a compound of Formula (III)or a salt and / or solvate thereof, includes forming a first reaction stream comprising a compound of Formula (I) dissolved in an alcohol;flowing the reaction stream from step (a) through a continuous flow reactor at a temperature of about 100° C. to about 160° C. and at a flow rate of about 0.2 mL / min to about 5 mL / min; contacting the reaction stream from step (b) with a second reaction stream comprising a hydrazine source to form a combined reaction stream; and (d) flowing the combined reaction stream from step (c) through a continuous flow reactor at a temperature of about 100° C. to about 160° C. and at a flow rate of about 0.2 mL / min to about 5 mL / min.

The invention relates to the technical field of plant antibacterial agents, in particular to a sorbic hydrazide compound, a preparation method and application. The sorbic hydrazide compound is a compound as shown in a formula I or a formula II, or an isotope derivative of the sorbic hydrazide compound and a pesticide acceptable salt. The sorbic hydrazide compound has broad-spectrum inhibitory activity on phytopathogens such as plant pathogenic fungi, and has excellent inhibitory activity on more than ten kinds of plant pathogenic fungi, especially on oomycetes and ascomycetes pathogenic fungi such as downy mildew bacteria and powdery mildew bacteria. The sorbic hydrazide compound has the advantages of easily available raw materials, simple preparation, low cost and no toxicity to animals and plants, and can be used as an effective component or a synergistic component for development and application of a novel green efficient agricultural antibacterial agent.

The application belongs to the polyurethane chain extension technical field, and particularly relates to a kind of generally applicable polyurethane chain extender and a preparation method thereof. First, 4-aminobutyric acid derivatives are used to prepare a series of chain extender precursors containing amide groups or urea groups with a series of diacyl chlorides and diisocyanates. The chain extender precursors continue to generate hydrazine-based polyurethane chain extenders containing amide groups or urea groups by reacting with hydrazine hydrate in alcohol solvents. The bio-based chain extender belongs to hydrazine compounds, is green in source and has low toxicity. Compared with conventional amine chain extenders, the solubility is lower and the reaction rate is relatively controllable. High-density hydrogen bonds can be introduced into the polyurethane main chain to further enhance the strength and toughness of the polyurethane material. The preparation method is templated, and the required chain extender structure can be customized according to the actual application requirements, enriches the application of polyurethane products, and meets the diversified needs of people for polyurethane materials.

The invention relates to the technical field of self-assembly supramolecules, in particular to supramolecular hydrogel based on double-ended amphiphilic molecules as well as a preparation method and application of the supramolecular hydrogel. The double-end-group amphiphilic molecule provided by the invention has a structural formula as shown in a formula 1, and n is any integer in a range of 8-28. The double-end-group amphiphilic molecule can form supramolecular hydrogel in pure water, the supramolecular hydrogel has a very good selective removal effect on heavy metal ions in water, trace heavy metal ions in water can be selectively removed through a filtering system constructed by utilizing the supramolecular hydrogel, the treated water meets the related requirements of drinking water, and the application prospect is wide. Meanwhile, ions such as sodium, potassium and magnesium essential to the human body cannot be removed, heavy metal ions can be selectively removed through simple filtration, extra wastewater is not generated, and secondary pollution is avoided. The method is simple in process and relatively low in cost, is expected to replace the traditional reverse osmosis membrane technology, and has relatively good economic value.

This invention discloses a method for preparing the organic intermediate N'-(2,4-dichloro-5-isopropoxyphenyl)pentanoyl hydrazide, belonging to the field of organic synthesis technology. This invention provides a method for preparing the intermediate under nitrogen protection, using aryl bromide and pentanoyl hydrazide as reactants, and adding alkali, Cu₂O, and N₂. 1 N 2 N'-(2,4-dichloro-5-isopropoxyphenyl)pentanoylhydrazine is generated by a Ullmann coupling reaction involving bis(1-naphthyl)oxalamide, a relevant catalyst, and a water / alcohol solvent, followed by heating. This method utilizes inexpensive and readily available raw materials, has a simple operation process, operates under mild and environmentally friendly conditions, requires minimal post-processing, and is safe and efficient, making it suitable for large-scale industrial production.

The application belongs to the field of medicine, and particularly relates to a preparation method and anti-tumor application of a novel hirsutellin derivative. The novel hirsutellin derivative with a novel structure is prepared by using a simple and efficient synthesis method, and the specific structure is as follows: the in-vitro anti-tumor activity research of the compound in the application shows that the novel hirsutellin derivative has obvious inhibitory effect on the growth of human breast cancer cells (MDA-MB-231) and human gastric cancer cells (SGC7901), which shows that the hirsutellin derivative can be used as a lead compound or a candidate compound for development of an anti-tumor drug.

Aspects of the present application relates to solid state forms of Pirtobrutinib such as novel crystalline form P1, amorphous solid dispersions comprising Pirtobrutinib and pharmaceutically acceptable carriers and processes thereof, wherein the pharmaceutically acceptable carrier is selected from the group consisting of HPMC phthalate, HPC, Eudragit L100, microcrystalline cellulose, carboxymethyl cellulose, mannitol, Neusilin, cellulose acetate phthalate, polyvinyl alcohol, polylactic-co-glycolic acid, polyvinyl acetate phthalate, sodium alginate, beta cyclodextrin, and mixtures thereof. Aspects of the present application relates to process for the preparation of [(1S)-2,2,2-trifluoro-l-methyl- ethyl]hydrazine or its salts.

The invention relates to the technical field of high polymer materials, and particularly provides a solvent-free preparation method and a recovery method of dynamic cross-linked epoxy resin. The preparation method comprises the following steps: reacting a diamine compound with olefine acid ester, and then reacting with hydrazine hydrate to obtain an oily hydrazide monomer; performing solvent-free mixing, defoaming, injection molding and curing on the monomer, a modified amine curing agent, terminated isocyanate and an epoxy resin monomer according to a specific molar ratio to obtain the epoxy resin based on the amido urea dynamic bond; the recycling method comprises the following steps: degrading the obtained epoxy resin, a diamine compound and an organic solvent into degradation liquid under heating, then adding an epoxy resin monomer into the degradation liquid, and curing to obtain regenerated resin. According to the method, green and efficient preparation of the epoxy resin is achieved, the tensile strength of the recycled resin is improved by 28.56% or above in a breakthrough mode, the glass-transition temperature is increased by 45% or above, and closed-loop recycling of performance upgrading is achieved.

This invention belongs to the field of medicinal chemistry and relates to ferulate hydrazide compounds and their uses. Specifically, this invention provides compounds of formula I or pharmaceutically acceptable salts, stereoisomers, tautomers, polymorphs, solvates, racemates, prodrugs, or metabolites thereof, which exhibit good antitumor activity.

The application discloses a method for preparing N-substituted lactamide by catalyzing aminolysis of polylactic acid by using an ionic liquid. The method comprises the following steps: using the ionic liquid as a solvent and / or a catalyst, and allowing polylactic acid to perform aminolysis reaction with an organic amine compound to generate the N-substituted lactamide. The method does not need other transition metal catalysts, has mild reaction conditions, and has no by-products, and thus has a strong industrial application prospect.