92results about "Hydrazide preparation" patented technology

The application discloses a continuous synthesis method of an amicarbazone intermediate 5-isopropyl-1,3,4-oxadiazole-2(3H)-ketone. The method comprises two continuous processes of hydrazinolysis and phosgenation: continuously feeding a mixture of isobutyric acid and a solvent, a mixture of hydrazine hydrate and a catalyst into a hydrazinolysis continuous reactor respectively, carrying out a warming reflux dehydration reaction, and obtaining an isobutyryl hydrazine solution shown in formula I; continuously feeding the isobutyryl hydrazine solution and phosgene into a phosgenation continuous reactor, carrying out a phosgenation reaction, and after distillation and desolventizing treatment of a reaction solution, obtaining 5-isopropyl-1,3,4-oxadiazole-2(3H)-ketone shown in formula II. The application has the advantages of simple reaction flow, high product yield, and significant production efficiency improvement, and is suitable for industrial large-scale production.

A continuous process for preparing a compound of Formula (III), or a salt and / or solvate thereof, includes forming a first reaction stream comprising a compound of Formula (I) dissolved in an alcohol; flowing the reaction stream from step (a) through a continuous flow reactor at a temperature of about 100 °C to about 160 °C and at a flow rate of about 0.2 mL / min to about 5 mL / min; contacting the reaction stream from step (b) with a second reaction stream comprising a hydrazine source to form a combined reaction stream; and (d) flowing the combined reaction stream from step (c) through a continuous flow reactor at a temperature of about 100 °C to about 160 °C and at a flow rate of about 0.2 mL / min to about 5 mL / min.

The present application relates to the technical field of rubber, in particular to a kind of hydrazide compound, rubber composition and its preparation method and application.The present application provides a kind of hydrazide compound, is mono-hydrazide compound or double hydrazide compound, they have lower melting point, can be well dispersed in rubber matrix in the range of mixing temperature, further ensure its effect.And the hydrazide compound of this kind is added to rubber composition, can obtain the tire product of processing performance improvement, dynamic modulus promotion, anti-wet sliding and balanced rolling resistance.

A preparation method of N '-((2S, 3S)-2-(benzyloxy) pent-3-yl) formylhydrazine oxalate enzyme belongs to the field of medical intermediates, and comprises the following steps: step 1, preparing a buffer solution of a compound enzyme preparation; step 2, adding (2S)-2-benzyloxy-3-pentanone into a solvent A, and then adding a buffer solution of the compound enzyme preparation for reaction; 3, filtering, and carrying out an activation reaction on the filtrate; 4, filtering, removing the solvent, adding the obtained solid into a solvent B, and then adding formylhydrazine for reaction; 5, filtering, removing the solvent, adding the obtained solid into a solvent C, and then adding oxalic acid for reaction; and 6, drying the solid obtained by filtering to obtain the N '-((2S, 3S)-2-(benzyloxy) pent-3-yl) formylhydrazine oxalate. According to the method, the yield of the N '-((2S, 3S)-2-(benzyloxy) pent-3-yl) formylhydrazine oxalate can be increased, and the production cost is effectively reduced.

Object of the present invention is an improved process for the preparation of Indomethacin of formula (I): by means of the precipitation, crystallization, re-crystallization or re-slurry of the intermediate 4-chloro-N-(4-methoxyphenyl)benzohydrazide in a mixture comprising tetrahydrofuran and a C1-C4 linear or branched alkyl alcohol.

The invention discloses a hydrazide compound taking syringic acid as a lead as well as a preparation method and application of the hydrazide compound, and a biological activity test result shows that all the compounds have excellent and broad-spectrum antibacterial activity on tested plant pathogenic fungi. Wherein the inhibition effect of most target compounds on plant pathogenic fungi is superior to that of positive control boscalid, the compound 11 has the best antibacterial effect on rhizoctonia solani, fusarium graminearum, alternaria solani, colletotrichum frutescens and colletotrichum sorghum, and EC50 values of the compound 11 are respectively 0.258 [mu] g / mL, 0.679 [mu] g / mL, 0.424 [mu] g / mL, 0.384 [mu] g / mL and 0.975 [mu] g / mL; for colletotrichum gloeosporioides, the compound 12 has the best antibacterial effect, and the EC50 value of the compound 12 is 0.989 mu g / mL; and secondly, a compound 11 with an EC50 value of 1.248 [mu] g / mL. The hydrazide compound prepared by taking syringic acid as a lead has excellent, broad-spectrum and efficient plant pathogenic microorganism resisting activity, and can be used for preventing and treating plant diseases caused by plant pathogenic microorganisms.

The present invention relates to the technical field of drug intermediate synthesis, and particularly relates to a preparation method of posaconazole starting material SM3. CeCl3·7H2O and sodium borohydride are added to compound POS-1 for an asymmetric reduction reaction to obtain compound POS-2. Compound POS-2 reacts with 3,5-bis(trifluoromethyl)benzenesulfonyl chloride to obtain compound POS-3. Hydrazine hydrate attacks from the back of compound POS-3 with a larger steric hindrance to undergo an SN2 reaction to obtain a stereoselectively specific compound POS-4. Compound POS-4 then reacts with ethyl formate and forms a salt with oxalic acid to obtain the product posaconazole starting material SM3. By means of asymmetric reduction of carbonyl groups and selective nucleophilic substitution, the present invention effectively avoids the chiral resolution step, thereby reducing the content of isomeric impurities. The prepared product not only has a high ee value, but also the yield is significantly improved, thereby greatly reducing the production cost.

The invention relates to the technical field of biochemical analysis, in particular to a stable isotope labeling reagent for amino / azide / carboxyl compounds as well as a preparation method and application of the stable isotope labeling reagent. The stable isotope labeling reagent is structurally characterized in that one end of the stable isotope labeling reagent is carboxyl, alkynyl and hydrazide groups and is connected with reactive groups of a target object, and the other end of the stable isotope labeling reagent is dimethyl-substituted tertiary amino, so that high-strength fragment ions are generated, and meanwhile, groups with different stable isotopes and poor quality are realized; therefore, the interference of matrix effect on quantification is reduced.

A method for preparing the insecticide N-(1-methylcyclopropyl)-2-(3-pyridinyl)-2H-indazole 4-carboxamide is disclosed. A method for preparing the intermediate N-(1-methylcyclopropyl)-2-(3-pyridinyl)-2H-indazole 4-carboxamide is also disclosed.

The application belongs to the technical field of chemical production, and particularly relates to a preparation method and a preparation device of adipic acid dihydrazide. The preparation method of the adipic acid dihydrazide comprises the following steps: S1, treating raw materials; S2, adding the raw materials into a reaction tank for reaction; S3, cooling and crystallizing; S4, washing the crystals and purifying; and S5, drying and packaging the purified crystals. In the process of the reaction of the raw materials in the reaction tank, the raw materials are fully mixed by a mixing mechanism arranged in the reaction tank. The mixing mechanism pushes the mixed solution in the upper layer downward and pushes the mixed solution in the lower layer upward, so that the mixed solution flows in the axial direction, the mixed solution in the middle layer is subjected to turbulent flow, the mixed solution is more uniformly mixed, and the mixing effect is improved.

To provide plasminogen activator-1 (PAI-1) inhibitor compounds and uses thereof in the treatment of any disease or disorder associated with elevated PAI-1.SOLUTION: The disclosure includes, but is not limited to, the use of such compounds to prevent or reduce thrombosis and fibrosis, to promote thrombolysis, and to modulate lipid metabolism and treat diseases or disorders associated with elevated PAI-1, cholesterol, or lipid levels.SELECTED DRAWING: None

The invention discloses high-performance recoverable fluoropolyimide plastic as well as a preparation method and a recovery method thereof, and belongs to the technical field of recoverable plastic. According to the invention, the bifunctional aldehyde and the bifunctional hydrazide monomer are subjected to polycondensation to prepare the plastic, so that the molding processing of the plastic becomes convenient, and the gelation problem caused by crosslinking of a polyfunctional system is avoided. The prepared high-performance recyclable fluoropolyimide plastic has excellent mechanical properties and toughness, good optical properties, outstanding chemical stability and thermal properties, and unique selective solubility, so that the fluoropolyimide plastic has the performance of recycling and reprocessing, and has wide application.

This invention relates to the field of pharmaceutical impurity preparation technology, and discloses a method for synthesizing apixaban genotoxic impurity I. The steps include: S1. performing an addition reaction of compound II in an alkaline system to generate compound III; S2. subjecting the product of S1 to elimination and isomerization reactions under heating, separating the reaction product to obtain apixaban genotoxic impurity I. The synthesis method of this invention has high safety, low raw material cost, and can achieve a one-pot reaction while ensuring yield and product purity (no product separation and purification is required between each reaction step; only one separation and purification is needed after obtaining the final product).

The present invention provides a preparation method of a posaconazole intermediate. In this method, 3-pentanone is used as the starting material, and the posaconazole intermediate is prepared through an asymmetric catalytic oxidation reaction, a substitution reaction and an asymmetric reductive amination reaction. The product obtained by this method has high purity and good yield. The preparation method has fewer steps, the raw materials are cheap and easily available, the operation is simple, the total yield is high, and it is more suitable for industrial production.

The invention provides polyether hydrazide as well as a preparation method and application thereof. The preparation method comprises the following steps: firstly, taking polyether amine and anhydride as raw materials, carrying out ring-opening reaction to prepare polyether carboxylic acid, then carrying out esterification reaction on the polyether carboxylic acid and monofunctional alcohol to obtain polyether amide carboxylic acid methyl ester, and finally reacting the polyether amide carboxylic acid methyl ester with hydrazine hydrate to generate polyether hydrazide. The preparation method of the polyether hydrazide has the characteristics of wide raw material source and simple route, can effectively reduce the production cost and improve the yield and purity, and is beneficial to industrial production; the oil solubility of the polyether hydrazide can be accurately adjusted by regulating and controlling the length of a polyether chain segment in a polyether hydrazide molecule, and the potential application scene of the polyether hydrazide is further expanded. The invention further provides resin based on polyether hydrazide, the resin has good degradability and excellent mechanical strength, on one hand, the resin can be hydrolyzed to generate hydrazide groups, and the degradability is achieved; on the other hand, the resin can generate intermolecular hydrogen bond synergy through a plurality of hydrogen bond sites in the polyether hydrazide structure, so that the mechanical strength is improved.

The invention provides an ADH-free heat-yellowing-resistant agent without formaldehyde adsorption and a preparation method thereof, and belongs to the technical field of heat-yellowing-resistant agents. According to the invention, alkyl diacid dihydrazide and organic acid are used as raw materials, carboxyl and hydrazide are acetylated to close active amido and block the combination path of the active amido and formaldehyde, so that the problem that the fabric adsorbs formaldehyde after being finished with a heat-resistant yellowing agent is solved, and meanwhile, the strong reducibility of the hydrazide structure is retained; the yellowing value of the fabric in the heat setting or ironing process is obviously reduced. The thermal yellowing resistant agent has a neutral structural unit with thermal stability, and the structural unit is not easy to decompose at high temperature and can effectively block the oxidative degradation path of nylon. The preparation process of the heat-yellowing-resistant agent does not need to use an organic solvent, the heat-yellowing-resistant agent can be prepared only through one-step reaction, the preparation process is simple, and the cost is low.

The application discloses a kind of photo-curing mussel biomimetic acylhydrazone and its preparation method and application, the structural formula of the photo-curing mussel biomimetic acylhydrazone is as shown in formula (I).The photo-curing mussel biomimetic acylhydrazone of the application has catechol structure and carbon-carbon double bond, raw material is low in price, synthesis process does not need to modify catechol structure, preparation method is simple, can reduce the synthesis difficulty and production cost of mussel biomimetic material.The mussel biomimetic photo-curing adhesive composition prepared by using photo-curing mussel biomimetic acylhydrazone as raw material has good adhesive property, and can improve the problem of insufficient adhesion and failure of photo-curing adhesive, and prevent falling.

This application discloses a method for synthesizing adipic acid dihydrazide, belonging to the field of organic synthesis technology. The method involves adding adipic acid, an alcohol solution, and a strongly acidic cation exchange resin catalyst to a reaction vessel for esterification to obtain adipic acid dialkyl ester. The adipic acid dialkyl ester, a co-catalyst, and hydrazine hydrate are then subjected to a hydrazolysis reaction in a three-stage temperature-controlled process to obtain the final product, adipic acid dihydrazide. The co-catalyst system significantly reduces the activation energy of the hydrazolysis reaction, and the amount of hydrazine hydrate used is greatly reduced. The high efficiency conversion and low addition amount of hydrazine hydrate result in a significant reduction in the free hydrazine content of the product, making the process simpler, more energy-efficient, and environmentally friendly. The three-stage temperature control, from low-temperature induction nucleation to the medium-temperature main reaction and then to high-temperature completion, balances reaction selectivity and conversion rate, avoiding side reaction problems caused by insufficient zone control under isothermal reaction conditions. The catalyst is widely available and cost-controllable, and the process conditions are mild, making it suitable for industrial production.

The benzyl hydrazine derivative has the advantages of being good in activity and novel in structure, the benzyl hydrazine derivative serves as an RIPK1 small-molecule inhibitor, necroptosis induced by TNF-alpha can be reduced, and therefore the anti-inflammatory effect is achieved, and the benzyl hydrazine derivative can be used for preparing drugs for treating inflammation-related diseases such as diabetic nephropathy.

The invention relates to the technical field of plant antibacterial agents, in particular to an alkenyl hydrazide compound, a preparation method and application thereof and a plant antibacterial agent. The hydrazide compound disclosed by the invention has an efficient and broad-spectrum inhibition effect on more than ten plant pathogenic fungi, has the advantages of simple structure, easiness in large-scale preparation and no toxicity to animals and plants, and can be used as an effective component or a synergistic component for development and application of a novel green and efficient agricultural antibacterial agent.

The invention discloses a synthesis method of 4-(3-hydrazide oxopropyl) benzoyl hydrazine, and belongs to the field of organic synthesis. According to the invention, 4-(3-ester oxopropyl) methyl benzoate is used as a raw material, and is subjected to a hydrazide reaction with hydrazine hydrate in a reaction solvent to obtain the product 4-(3-hydrazide oxopropyl) benzoyl hydrazine. And under optimal reaction conditions, after the reaction liquid is recycled for multiple times, the comprehensive yield can reach 87%, and the product purity is relatively high.

The invention discloses a preparation method of a repairable solvent-resistant dynamic cross-linked epoxy resin material, which successfully synthesizes a novel oily hydrazide molecule through molecular design, can realize solvent-free preparation of an amido urea-based dynamic polymer material, and has the advantages of easily available raw materials and simple preparation process. The dynamic cross-linked network is introduced into the epoxy resin, so that the epoxy resin can be endowed with dynamic characteristics, but the solvent resistance of the epoxy resin is reduced due to introduction of dynamic bonds. By adjusting the proportion of the curing agent, the blocked isocyanate and the epoxy monomer, the epoxy resin which not only has a high epoxy crosslinking structure, but also contains an amido urea-based dynamic crosslinking structure is prepared, and the problem of contradiction between good dynamic property and solvent resistance of the epoxy resin is solved. Remodeling and repairing of the resin can be achieved after the resin is crushed and then subjected to hot pressing, and in addition, the resin shows good tolerance to strong acid, strong alkali and strong polar solvents.

The present invention provides a class of benzoyl hydrazide compounds, belonging to the technical field of pharmaceutical chemistry. The structure of the benzoyl hydrazide compounds is shown in general formula I. The benzoyl hydrazide compounds of the present invention have the effect of killing Schistosoma japonicum. The emergence of new drugs overcomes the problem of drug resistance caused by long-term use of existing anti-schistosomiasis drugs, and has important scientific value and research value for finding new anti-schistosomiasis drugs.

The invention discloses an aryl bishydrazide compound with a structural formula shown in the following formula: in-vitro experiment results show that the compound has remarkable inhibitory activity on dengue virus (DENV), the therapeutic index (TI) of the compound is remarkably higher than that of a clinical positive control drug ribavirin, and in addition, the compound can be used for preparing an aryl bishydrazide compound with the structural formula shown in the specification. The preparation method disclosed by the invention is simple and efficient in process, good in yield and mild in reaction condition, has good large-scale production potential, and provides a feasible synthesis basis for further clinical transformation and application.

The application discloses a kind of hydrazine compounds with eugenol as lead and its preparation method and application, and the biological activity test result shows that all compounds are excellent, broad-spectrum antibacterial activity to the plant pathogenic fungi tested.The inhibition effect of most target compounds on plant pathogenic fungi is better than that of positive control rynaxapyr, and the antibacterial effect of compound 11 on rhizoctonia solani, fusarium graminearum, alternaria solani, phoma exigua var. horii and phoma sorghicola is the best, and the EC 50 Values are 0.258 μg / mL, 0.679 μg / mL, 0.424 μg / mL, 0.384 μg / mL and 0.975 μg / mL respectively; for the gossypium gossypium, the antibacterial effect of compound 12 is the best, and the EC 50 Value is 0.989 μg / mL; followed by compound 11, and the EC 50 Value is 1.248 μg / mL.The hydrazine compounds prepared with eugenol as lead have excellent, broad-spectrum and high-efficiency anti-plant pathogenic microorganism activity, and can be used for preventing and treating plant diseases caused by plant pathogenic microorganisms.

The present invention belongs to the technical field of organic synthesis, and specifically relates to a preparation method of N',N'-diarylhydrazide compounds. The present invention provides a preparation method of N',N'-diarylhydrazide compounds, which comprises the following steps: mixing an arylhydrazine compound, an aldehyde compound, a catalyst, a base and a polar organic solvent, and carrying out a coupling addition reaction to obtain the N',N'-diarylhydrazide compound. The preparation method of the present invention has the advantages of mild conditions, easy control, high reaction efficiency, step economy, cheap and easily available raw materials, no use of oxidants, good functional group tolerance, etc., and the prepared N',N'-diarylhydrazide compounds have a high purity, with a purity of 98.5-99.9%, and have great market promotion value. Compared with multi-step synthesis reactions, the target product can be obtained by a one-step reaction in the present invention, and the reaction yield reaches 88%, having the advantages of high reaction efficiency and step economy.

The application belongs to the technical field of biodegradable polyester nucleating agent synthesis, and discloses a small-molecule hydrazide nucleating agent for improving the crystallization ability of polylactic acid, and a preparation method and application thereof.A novel polylactic acid nucleating agent designed and synthesized by the application is prepared by adding terephthaloyl chloride, methoxybenzoyl hydrazine and a bundling agent into a solvent and synthesizing at 60 DEG C.The nucleating agent is mixed with polylactic acid by a melt blending method, and is extruded or injection molded into a polylactic acid product, so that good nucleation efficiency is provided for polylactic acid during preparation, the nucleation effect is stable, the polylactic acid product obtained has a high crystallization peak temperature, excellent mechanical properties and other characteristics.The preparation method of the nucleating agent is simple, mass production can be realized, and the nucleating agent can be widely applied to the preparation of industrial polylactic acid plastic products.

An improved process for the preparation of Indomethacin of formula (I):is provided by means of the precipitation, crystallization, re-crystallization or re-slurry of the intermediate 4-chloro-N-(4-methoxyphenyl)benzohydrazide in a mixture containing tetrahydrofuran and a C1-C4 linear or branched alkyl alcohol.

The invention discloses a high-enthalpy-value metal-organic coordination material as well as preparation and application thereof, and belongs to the field of phase change energy storage. According to the metal-organic coordination material, transition metal nitrate is coordinated with acethydrazide in a small molecule amide ligand to obtain a series of metal-organic coordination materials. The material realizes the synergistic effect of a hydrogen bond network and a metal coordination bond, so that the material has the advantages of high phase change temperature, large enthalpy value and the like. Compared with a traditional phase change material, the phase change material has excellent thermodynamic property and thermal stability. The device can be applied to the field of heat management of high-power equipment, has the advantages of high energy storage density, low material consumption and the like, and has wide application prospects.