273results about "Hydrazide preparation" patented technology

The present invention provides diacylhydrazine ligands and chiral diacylhydrazine ligands for use with ecdysone receptor-based inducible gene expression systems. Thus, the present invention is useful for applications such as gene therapy, large scale production of proteins and antibodies, cell-based screening assays, functional genomics, proteomics, metabolomics, and regulation of traits in transgenic organisms, where control of gene expression levels is desirable. An advantage of the present invention is that it provides a means to regulate gene expression and to tailor expression levels to suit the user's requirements.

The invention provides a degradable hydrazide latent epoxy resin curing agent. The curing agent can be polymerized with epoxy resin to generate a degradable crosslinked polymer; and the degradable crosslinked polymer can be degraded in a mixed system of an acid and a solvent under the conditions of heating and stirring. The invention also provides a prepreg, consisting of the curing agent, the epoxy resin, an auxiliary material and a reinforcing material. The invention also provides a reinforcing composite material which is prepared from the curing agent, the epoxy resin, the auxiliary material and the reinforcing material. The reinforcing composite material can be prepared by a prepreg forming method. The reinforcing composite material can be degraded in the mixed system of the acid and the solvent under the conditions of heating and stirring, and can be recycled and reused after being neutralized. The reinforcing composite material has excellent mechanical property and is suitable for the field of application of different composite materials; and the degrading and recycling method of the reinforcing composite material is simple, economic, mild in condition and easy to control.

A process for the preparation of 4-[4-[4-[4-[[(3R,5R)-5-(2,4-difluorophenyl)tetrahydro-5-(1H-1,2,4-triazol-1-ylmethyl)-3-furanyl]methoxy]phenyl]-1-piperazinyl]phenyl]-2-[(1S,2S)-1-ethyl-2-hydroxypropyl]-2,4-dihydro-3H-1,2,4-triazol-3-one compound of formula-1, its intermediates and polymorphs thereof. (I)

The invention discloses a catalytic preparation method for hindered phenol derivative antioxygen. In the invention, a catalytic dehydration process is adopted to prepare the hindered phenol derivative antioxygen, the reaction raw materials are subjected to acidification and monohydrazidation respectively to form two intermediates, and thionyl chloride is not used so as to reduce pollution; and then a solvent and two intermediates are added into a reactor and heated and refluxed to undergo dehydration in the presence of a catalyst, and water is separated out by a water segregator. In the invention, due to the adoption of the catalyst, the reaction temperature is lower, the raw material utilization rate is high, the reaction time is short, and the product yield is high; therefore, the method can contribute to the reduction of production cost and is suitable for industrial production. Evaluation on the use of the antioxygen in polyolefin wire and cables shows that the antioxygen prepared by the method disclosed by the invention has high antioxygen performance and metal passivating capacity.

The invention relates to a preparation method of trimesoyl hydrazone series derivatives and application of the trimesoyl hydrazone series derivatives as probe molecules for identifying fluorine ions. The preparation method comprises the steps of dissolving trimesic acid, concentrated sulfuric acid and ethanol according to the mass ratio of 1:0.25:20 into ethanol, and refluxing for 48 hours to obtain a white product trimesic acid ethyl ester; dissolving trimesic acid ethyl ester, hydrazine hydrate and methanol according to the mass ratio of 1:0.5:5 into methanol, cooling reaction liquid to room temperature when points of raw materials do not exist on a thin-layer plate, and precipitating a large amount of white solid trimesoyl hydrazine; dissolving trimesoyl hydrazine and salicylaldehyde derivatives according to the molar ratio of 1:4.5 into a proper amount of methanol, adding p-toluenesulfonic acid serving as a catalyst, refluxing for 12 hours, and then cooling to room temperature to obtain fluorescent probe molecules.

The invention provides a benzoyl hydrazone neuraminidase inhibitor. The inhibitor is characterized in that the structure of the inhibitor is shown in the formula I. The inhibitor has the advantage that according to the structural formula, the synthesized compound has good neuraminidase inhibiting activity.

The invention discloses a synthesis method of diethyl azodicarboxylate. The synthesis method comprises the following steps that (1) under the effect of sodium ethoxide, diethyl carbonate and ethyl carbazate are heated for reaction for 1 to 6 hours, the pH of solution is regulated to 3 to 8, white crystals are separated out, the recrystallization is carried out, and hydrogenated diethyl azodicarboxylate is obtained; and (2) the hydrogenated diethyl azodicarboxylate is added at minus 15 DEG C to 45 DEG C, in the acid solution, bromine or hydrobromic acid or sodium bromide and potassium bromide are used as catalysts, excessive hydrogen peroxide is dripped, the reaction is carried out for 1 to 10 hours, the extraction is carried out, organic solvents are removed through distillation, and saffron diethyl azodicarboxylate is obtained. The invention also provides a hydrogenated diethyl azodicarboxylate intermediate and a synthesis method of the hydrogenated diethyl azodicarboxylate intermediate. The synthesis method has the advantages that diethyl carbonate is used as raw materials, cleanness and environment protection are realized, no pollution exists, raw materials can be cyclically utilized, the economy is better, the operation is simple, the reaction temperature range is wide, the reaction is stable, the energy consumption is low, the yield is high, and the industrial production is favorably realized.

The present invention discloses the preparation process of dihydrazide adipate with free hydrazine content lower than 10 ppm. The preparation process includes synthesis of adipic acid and methanol to produce dimethyl adipate, the subsequent synthesis with hydrazine hydrate to obtain crude dihydrazide adipate product, and distilling the crude dihydrazide adipate product at negative pressure condition in medium temperature water vapor to obtain refined dihydrazide adipate product with free hydrazine content lower than 10 ppm. The refined dihydrazide adipate product has high performance, low pollution and environment friendship and is used in producing environment friendly water paint.

The invention discloses a method for preparing adipic acid dihydrazide. The method comprises the following steps of (1) adding adipic acid and strong-acidic cation exchange resin taken as a catalyst into methanol, then heating a reaction system till a reflux state is formed, and performing an esterification reaction under the reflux state; after the completion of the esterification reaction, adding ammonia water into the reaction system at a temperature of 5 to 40 DEG C, then adding hydrazine hydrate, and enabling the reaction system to perform a hydrazination reaction at a temperature of 5 to 40 DEG C; after the completion of the hydrazination reaction, filtering out the catalyst, and preparing a reaction product; (2) obtaining an adipic acid dihydrazide crude product by means of removing methanol from a product obtained through a distillation reaction; obtaining the adipic acid dihydrazide through washing and drying the adipic acid dihydrazide crude product. The method disclosed by the invention has the advantages that the conversion rate can be improved, the side reaction is less, the catalyst can be recycled, and the production cost is low.

The invention relates to a substituted hydrazide compound with a structure shown in the following general formula I, its preparation method, medicinal compositions and application thereof. The compound can be used for preparing medicines treating diseases caused by B-Raf and its isoenzymes or mutants (such as B-RafV600E).

The invention discloses an acyl benzylamine compound and a use thereof. The acyl benzylamine compound has wide-spectrum bactericidal activity and has a general structural formula shown in the formula I, wherein definitions of all substituent groups in the formula I are shown in the patent specification. The acyl benzylamine compound has wide-spectrum bactericidal activity, has effects of treating symptoms caused by cucumber downy mildew, corn rust and wheat powdery mildew, and especially, has excellent effects of preventing cucumber downy mildew and corn rust. The acyl benzylamine compound also has good effects of preventing and treating wheat powdery mildew. The acyl benzylamine compound has the advantages of high activity, low use amount and good safety.

The invention discloses a preparation technology of methoxyfenozide. The preparation technology comprises steps of a condensation reaction and an acylation reaction. The preparation technology has the advantages as follows: intermediate raw materials are recycled and reused, so that the production cost and the waste water treatment difficulty are reduced, the purity of finished products is high, the reaction process is convenient to control, and the requirement of modern pesticide preparation is met.

The invention provides a three-phase catalyst Pd@covalent organic framework (COF)-QA as well as a preparation method thereof and an application of the catalyst in catalysis of a Suzuki-Miyaura reaction, and belongs to the technical field of catalyst preparation. The three-phase catalyst Pd@COF-QA provided by the invention is obtained by reacting covalent organic framework (COF)-QA with palladium acetate at room temperature, the preparation method is simple and convenient, through experimental verification, the three-phase catalyst has a high utilization rate, the reaction conditions are mild,the catalytic costs can be effectively reduced, high temperature and an organic solvent are not needed, the usage amount of the catalyst is less, and heterogeneous catalysis can be realized without other additives; and at the same time, the catalyst can be reused and easy to recover, the utilization rate of the catalyst is improved, the costs are reduced, and industrialized promotion application is facilitated.

The present invention relates to method for the preparation of an ω-amino-alkane(thio)amide having the general formula (6)

Furthermore, novel intermediates and partial reaction steps of the claimed method are disclosed.