Substituted hydrazide compound, and its preparation method, medicinal compositions and application
Patent Information
- Authority / Receiving Office
- CN · China
- Current Assignee / Owner
- SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
- Publication Date
- 2012-11-14
- Estimated Expiration
- Not applicable · inactive patent
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Abstract
Description
technical field
[0001] The present invention relates to the fields of medicinal chemistry and pharmacotherapeutics, and more specifically relates to substituted hydrazide compounds and their preparation methods, pharmaceutical compositions and applications. This type of compound can be used for preparing and treating B-Raf and its isoenzymes or mutants (such as B-Raf V600E ) of the disease caused by the drug. Background technique
[0002] Raf kinase and its mediated Raf / MEK / ERK (MAPK) pathway play a significant role in tumor progression and metastasis. It is currently known that the transduction pathway MAPK exists in all eukaryotic cells, and it transmits signals from the extracellular to the nucleus through the specific cascade phosphorylation of Ras, Raf, MEK and ERK. In many tumor cells, this pathway is up-regulated, and Raf is a key kinase in this pathway, which can exert its signal transduction regulation in a Ras-dependent or Ras-independent manner. As a downstream...