2 results about "Diethyl azodicarboxylate" patented technology

The invention belongs to the technical field of manufacturing of optoelectronic devices, and particularly relates to a stripping liquid additive for recycling waste liquid and a preparation method of the stripping liquid additive. The preparation method comprises the following steps: (1) reacting benzotriazole, concentrated hydrochloric acid and paraformaldehyde to obtain a first intermediate product; (2) mixing the first intermediate product, N, N-dimethylethylenediamine, anhydrous acetonitrile and an acid-binding agent, carrying out heating reaction under the protection of nitrogen, cooling to room temperature, and carrying out suction filtration, purification and vacuum drying to obtain a second intermediate product; and (3) mixing the second intermediate product, polyethylene glycol monomethyl ether, triphenylphosphine and anhydrous tetrahydrofuran, dropwise adding a toluene solution of diethyl azodicarboxylate, reacting, carrying out reduced pressure distillation, adding diethyl ether, separating out a solid, carrying out suction filtration, concentrating the filtrate, and carrying out purification, reduced pressure distillation and vacuum drying. The additive can improve the efficiency and effect of the stripping liquid, and is low in corrosivity.

This invention relates to a method for the direct synthesis of Aramchol from cholic acid, belonging to the field of organic synthesis technology. The key technical point of this invention is the method for the direct synthesis of Aramchol from cholic acid. First, eicosanoyl chloride is prepared from arachidic acid and thionyl chloride. Then, eicosanoamide is prepared from eicosanoyl chloride and ammonia-methanol solution. The eicosanoamide is added to tetrahydrofuran, followed by the addition of cholic acid, diethyl azodicarbonate, and triphenylphosphine. Aramchol is synthesized under the action of diethyl azodicarbonate and triphenylphosphine. This method overcomes the shortcomings of existing techniques for synthesizing Aramchol from cholic acid, such as excessively long reaction routes, large consumption of sodium azide and eicosanoyl chloride, complex side reactions, and poor reproducibility. The preparation method involves reactions at room temperature, is simple to operate, has short steps, convenient post-processing, and high yield, making it suitable for industrial application.