The invention discloses a color printing packaging box, which solves the problems that the prior art does not have waterproof, anti-fog, oil-proof, insect-proof and unsatisfactory physical strength. The packaging box of the present invention is square, and is made of degradable stone cardboard folded and pasted according to the fold marks on it. The front and back of the stone cardboard are printed with a layer of color pattern surface layer and monochrome inner layer respectively, and the color pattern surface layer is heated. Pressed with a layer of transparent waterproof and dustproof film, the stone cardboard includes the main body of the stone cardboard and the coating layer. The top of the packaging box is provided with square top ears that are opened inwardly and connected to the oval hole, and the box body of the packaging box is provided with a transparent window. The invention has simple structure, scientific and reasonable design, convenient use, effective waterproof, anti-fog, oil-proof and insect-proof, good sealing performance, high physical strength, beautiful appearance, fast forming speed of the packaging box, and internal product identification function, which greatly improves the The scope of application of the present invention is expanded.