16 results about "Anti-Adhesion Agent" patented technology

The invention provides a compound preparation containing macarovir, a preparation method and application of the compound preparation in anti-influenza treatment, the multi-layer pellet compound preparation sequentially comprises a pellet core layer containing macarovir, an isolating layer, an active layer and an enteric layer from inside to outside, the pellet core layer containing macarovir and a sustained-release material, the isolating layer comprises an adhesive and an anti-sticking agent, the active layer comprises a hydrophobic layer and a hydrophobic layer, and the enteric layer comprises a hydrophobic layer and a hydrophobic layer. The active layer comprises oseltamivir phosphate and an adhesive, and the enteric-coated layer is made of synthetic polymer materials. The multi-layer pellet provided by the invention has good compressibility, disintegrability and lubricity. The compound preparation solves the problems of drug resistance, drug interaction and children medication compliance. The preparation is suitable for single-drug or combined treatment of influenza A / B viruses, and is especially suitable for children and drug-resistant influenza patients.

The invention belongs to the technical field of pharmaceutical preparations, and provides a probucol sustained-release capsule for reducing the blood fat level and a preparation method thereof, and the probucol sustained-release capsule is prepared by filling a capsule shell with sustained-release pellets, the sustained-release pellet comprises a blank pellet core, a medicine carrying layer, an isolating layer and a sustained-release layer from inside to outside, wherein the medicine carrying layer comprises probucol and an adhesive in a mass ratio of (200-250): (8-12); the slow-release layer is prepared from eudragit RL PO, a plasticizer, a pore-foaming agent and an anti-sticking agent according to the mass ratio of (250 to 300) to (20 to 25) to (20 to 22) to (10 to 18); the pore-foaming agent is prepared from polyethylene glycol 400 and PVP K25 in a mass ratio of (8-12): (3-5). The probucol sustained-release capsule provided by the invention not only has an excellent sustained-release effect, but also enables drug absorption to be less affected by gastric emptying, reduces stimulation to gastrointestinal tracts, and can improve patient compliance.

The invention relates to a method for manufacturing a rotationally symmetrical part (100) made of a composite material for a gas turbine, the method comprising: winding a fibrous texture (140) over a plurality of superimposed turns on a mandrel in order to obtain a rotationally symmetrical fibrous preform (300), the preform extending in width in an axial direction, in thickness in a radial direction and in length in a circumferential direction; and densifying the fibrous preform with a matrix. During the winding of the fibrous texture, the method comprises inserting a strip of antiadhesive material between two adjacent turns of the fibrous texture, the strip of antiadhesive material extending in the circumferential direction along the interface between the adjacent turns and having a width of less than the width of the preform in the axial direction.

The invention provides a furosemide micro-tablet which is convenient to take and is used for treating edema diseases of children and a preparation method of the furosemide micro-tablet. The furosemide micro-tablet is prepared from an active ingredient, a filling agent, an anti-sticking agent and a lubricating agent, the active component is furosemide; the invention also provides a preparation method of the furosemide micro-tablet. Compared with the existing furosemide tablet, the furosemide micro-tablet has the characteristics of low dosage, convenience in swallowing, improvement of children administration compliance and the like. The furosemide micro-tablet process is controllable, easy to operate and suitable for commercial production.

The invention discloses functional feed for protecting liver and intestines of mandarin fish and a preparation method of the functional feed, and belongs to the technical field of feed. The functional feed for protecting the liver and the intestine of the mandarin fish comprises the following components: an intestine and liver protecting compound, an enteric coating material, an adsorbent, an anti-sticking agent, a protein source, a fat source, carbohydrate, compound vitamins and compound minerals. The preparation method comprises the following steps: firstly, preparing a coating solution, putting an intestine and liver protecting compound into a fluidized bed, spraying the coating solution at the bottom, curing, adding an adsorbent, and mixing to obtain a coated compound; then mixing a protein source, a fat source and carbohydrate to obtain a basic nutrient; and finally, mixing the coated compound, the basic nutrient mixture, the compound vitamins and the compound minerals, extruding and granulating, spraying an anti-sticking agent, and drying to obtain the feed. The functional feed for protecting liver and intestine of mandarin fish provided by the invention can inhibit fatty acid synthase in liver, reduce liver lipid deposition of mandarin fish, restore the liver-body ratio, improve the feed conversion rate and enhance the growth performance of mandarin fish.

The invention relates to the technical field of food processing, in particular to a macromolecular sustained-release coating material for a double-layer sustained-release composite tablet candy and a tablet candy prepared from the macromolecular sustained-release coating material, the coating material comprises a macromolecular base material, a plasticizer, a pore-foaming agent, an anti-sticking agent, a functional auxiliary agent and a solvent; the polymer base material comprises hydroxypropyl methylcellulose, ethyl cellulose and polyacrylic resin; the tablet candy comprises a double-layer core body, the double-layer core body comprises an inner-layer quick-release core and an outer-layer slow-release core, the inner-layer quick-release core comprises a quick-release active component, a filler, an adhesive and a lubricant, and the outer-layer slow-release core comprises a slow-release active component, a slow-release base material, a filler and a lubricant. The type of the sustained-release base material is matched with that of the hydroxypropyl methylcellulose in the coating material. A ternary polymer base material compounding system is adopted, and efficient stepped slow release of different active ingredients is achieved through the synergistic effect of hydrophilic and hydrophobic components and in combination with the structural design of a double-layer core body.

The invention relates to the technical field of lysine, and mainly relates to a lysine particle and a preparation method thereof, the preparation method of the lysine particle comprises the following steps: preparation of an inner layer: mixing L-lysine hydrochloride and microcrystalline cellulose under the condition of 500-800 rpm, then adding an adhesive solution, stirring to a soft material state, and then drying to obtain the inner layer; first-stage particles are obtained; middle-layer coating: spraying middle-layer coating liquid to the surfaces of the first-stage particles, and controlling the weight increment of the coating to be 8-12%; then drying and curing to obtain second-stage particles; preparing an outer layer: mixing Eudragit L100, an anti-sticking agent, a plasticizer and an alcoholic solution to obtain an outer layer coating solution; and then spraying the outer layer coating liquid on the surfaces of the second-stage particles, and controlling the weight gain of the coating to be 15-20% to obtain the lysine particles. The problem that lysine particles are prone to moisture absorption and caking can be effectively solved.

The invention belongs to the field of pharmaceutical preparations, and discloses a method for removing static electricity among pellets, which comprises the following steps: after the pellets are coated, spraying a coating solution containing hydroxypropyl methylcellulose and polyethylene glycol according to the condition that the total amount of the hydroxypropyl methylcellulose and the polyethylene glycol accounts for 3-8wt% of the mass of the pellets, controlling the material temperature at 35-50 DEG C when the coating solution is sprayed, and discharging after the pellets are dried. According to the preparation method, the coating solution containing the hydroxypropyl methylcellulose and the polyethylene glycol or the coating solution containing the hydroxypropyl methylcellulose, the polyethylene glycol and the anti-sticking agent is sprayed after the pellets are coated, so that the problem of static electricity among the pellets is solved, and the loss caused by static electricity in the transfer process is reduced. Compared with the prior art, the electrostatic eliminating effect can be achieved without operations such as external mixing of talcum powder and the like, and process steps and dust pollution are reduced.

Morning surge has appealed ample consideration owing to the relation between blood pressure levels and cardiovascular risk due to hypertensive organ damage. The present invention provides a formulation to modulate release profile, to synchronize release profile with chronobiologic antihypertensive therapy focusing primarily on morning surge. A time- controlled and position-controlled extended-sustained pulsatile drug delivery dosage formulation consisting of plurality of core particles, each particle having a base sealing layer of hydrophilic methylcellulose polymer, an intermediate layer comprising of an active drug, a binder and apore forming agent and an outerlayer comprising of an poly(meth)acrylates polymer, emulsifier, plasticizer, anti-tacking agent, wherein the drug release rate controlling polymer is EUDRAGIT FS SOD. The pellets are designed to carry the drugs exhibiting first pass metabolism and have a predetermined span of time of no release.

This invention relates to the field of PET hot pressing technology, specifically to a high-precision PET hot pressing molding equipment, comprising an upper shell and a lower shell. Multiple limiting rods are fixedly installed on the top of the lower shell, and limiting plates are slidably installed on the outer walls of the limiting rods. A hydraulic column is fixedly installed on the inner top of the upper shell, and the output end of the hydraulic column is fixedly connected to the outer wall of the limiting plate. A lower mold is installed on the top of the lower shell, and an upper mold is installed on the bottom of the limiting plate. The lower and upper molds cooperate to hot press PET material. A feeding assembly is provided on one side of the lower shell, and a discharging assembly is provided on the other side. A coating assembly is fixedly installed on the outer wall of the lower shell. The coating assembly can apply an anti-sticking agent to the surfaces of the lower and upper molds. The cooperation between the feeding and discharging assemblies can effectively improve production efficiency. The coating assembly can apply the anti-sticking agent to the surfaces of the upper and lower molds to prevent PET material from sticking to the mold surface during hot pressing, thus improving the mold's service life and hot pressing molding efficiency.

The present application provides a kind of aceclofenac enteric microcapsule and its preparation method, the microcapsule includes core and coating, the core includes pill core, aceclofenac, adhesive;The coating includes enteric coating material, plasticizer, anti-adhesive. By screening and optimizing the type and proportion of adhesive and enteric material, optimizing and controlling the preparation process parameters, effectively improve the stability and long-term stability of aceclofenac sustained-release microcapsule, block the release of drug in mouth and stomach, direct the drug to small intestine and slowly release, and the release effect is long-acting and durable.

To provide an adhesion inhibitor for cheese having powder swirling suppressed in production of cheese, cheese with the adhesion inhibitor for cheese, and a method of suppressing powder swirling in production of cheese and adhesion of cheese with each other during storage.SOLUTION: An adhesion inhibitor for cheese contains powder of a rough apparent specific gravity of 0.25 g / cc or more. The adhesion inhibitor for cheese adheres to the surface of cheese. A production method of cheese includes adhering the adhesion inhibitor for cheese to the surface of cheese. A method of suppressing powder swirling in production of cheese and adhesion of cheese with each other during storage includes adhering the adhesion inhibitor for cheese to the surface of cheese.SELECTED DRAWING: None

The application belongs to the technical field of coating materials, and particularly relates to a biodegradable medicinal casing based on a natural polysaccharide compound and a preparation method thereof. The biodegradable medicinal casing based on the natural polysaccharide compound comprises the following components in parts by weight: the enteric coating comprises the following components in parts by weight: 1-5 parts of pullulan, 20-25 parts of an enteric material, 6-10 parts of seaweed extract, 0.2-0.5 parts of a plasticizer, 5-9 parts of an anti-sticking agent, 0.20-0.25 parts of a pH regulator and 40-45 parts of water. The medicinal casing prepared in the application has high dissolution rate, strong stability and fast release speed when omeprazole is coated.

The invention discloses an antibacterial and mildew-proof packaging material as well as a preparation method and application thereof, and belongs to the field of antibacterial and mildew-proof packaging materials. The antibacterial and mildew-proof packaging material is prepared from the following components in parts by weight: 60 to 100 parts of biodegradable high polymer material and 0.3 to 2 parts of inorganic metal ion carrier, the invention relates to an antibacterial plastic which is prepared from the following components in parts by weight: 0.1-1 part of an organic antibacterial agent, 0.1-2 parts of an antifungal agent, 1-6 parts of polyethylene glycol, 0.1-5 parts of a plasticizer, 0.1-3 parts of a grafting monomer, 0.1-3 parts of an antistatic agent, 0.05-0.5 part of an antioxidant, 0.05-0.5 part of a light stabilizer, 0.1-2 parts of an anti-sticking agent and 0.1-5 parts of a coupling agent. The preparation method comprises the following steps: pretreating the raw materials, carrying out master batch on the active components, and carrying out integrated melt blending and granulation in a double-screw reaction extruder. The obtained composite particles can be used for forming antibacterial and mildew-proof films by a plastic film machine, or can be prepared into coating liquid to be coated on the surfaces of shoe boxes, clothing hangtags and clothing packaging boxes, so that long-acting antibacterial and mildew-proof effects are realized, and the composite particles are environment-friendly, efficient and flexible to process.

This invention discloses a low-smoke, odorless, environmentally friendly recycled coated sand process for cast iron. By combining powdered silica gel and modified erucamide to form a composite anti-adhesion agent, the anti-adhesion and refractory properties of the coated sand are significantly enhanced. The cured resin on the surface of the coated sand is removed by freezing and desquamation. By modifying aluminum nitride and preparing a desquamation aid, the desquamation rate of the coated sand waste is greatly improved. At the same time, a friction aid is prepared to enhance the particle shaping of the recycled coated sand, thereby enhancing the fluidity of the coated sand prepared from the recycled sand.

The application discloses an anti-sticking agent and a breeding cage modifier comprising the same, and belongs to the technical field of breeding. The anti-sticking agent comprises the following components in parts by weight: 20-50 parts of ethylene bis-stearamide, 10-30 parts of pregelatinized starch and 20-50 parts of an auxiliary agent. In the anti-sticking agent, the ethylene bis-stearamide is hydrolyzed into amine and acid under alkaline conditions after meeting water, loses the ability of being adsorbed on the surface of animal fur and automatically falls off from the surface of animal fur. After being mixed with the pregelatinized starch and the auxiliary agent, the anti-sticking agent produces a synergistic effect, effectively prevents the adhesion of materials under wet conditions, avoids the adsorption of materials on the animal fur to cause inflammation of the animals, does not affect the normal growth and development of the breeding animals and has a wide application range and can be used in the parturition period, the young period and the adult period of the breeding animals.