26 results about "Sildenafil" patented technology

1. The name of the design product: packaging box (sildenafil citrate tablets langmei 2). 2. The use of the design product: the design product is used for the packaging and protection of medicines. 3. The design points of the design product: in the pattern. 4. The picture or photo that best indicates the design points: perspective view.

The application discloses a preparation method of an amido pyrazole compound and a method for preparing sildenafil by using the same. The amido pyrazole compound is shown as formula I. The compound of formula I is prepared by using 2-pentanone as an industrial chemical, and can be used for synthesizing sildenafil which is a selective inhibitor of type 5 phosphodiesterase (PDE5). The method has the advantages of easy availability of raw materials, simple operation, avoidance of nitration reaction, avoidance of safety hidden dangers caused by the nitration reaction from a technical source, and avoidance of environmental protection pressure caused by a large amount of nitration waste liquid, and is suitable for development into a green and sustainable production process of sildenafil bulk drug.

1. Name of the product in this design: Packaging Box (Sildenafil Citrate Tablets). 2. Purpose of this design: for product packaging. 3. The key design features of this product are the combination of pattern and color. 4. The image or photograph that best illustrates the design's key features: the front view. 5. The design for which protection is sought includes color.

The invention relates to the technical field of biomedical materials, and discloses a chitin vascular sustained release stent, which is prepared from the following raw materials in parts by weight: 50 to 70 parts of chitin; 5 to 25 parts of polyethylene glycol; 1 to 5 parts of maleic acid; 10-20 parts of calcium chloride; 0.5 to 3 parts of L-lysine; 2 to 5 parts of a sildenafil prodrug; 0.5 to 5 parts of dopamine hydrochloride; 0.5 to 5 parts of (2 amino ethyl) trimethyl ammonium chloride hydrochloride; 1 to 10 parts of sodium tripolyphosphate; 0.5 to 5 parts of nonanoic acid; and 0.1-2 parts of magnesium chloride. Chitin is matched with polyethylene glycol and calcium chloride to be dissolved out to form a swellable porous structure, residual aldehyde groups are sealed through nonanoic acid and L-lysine, and an oxidizing agent and soluble by-products are removed through washing in cooperation with sufficient deionized water, so that the scaffold is gradually dissolved in body fluid and is absorbed by tissues, and the scaffold has a good biocompatibility. Meanwhile, the stimulation of free oxidants and active aldehyde groups on cells and tissues is reduced, so that lower cytotoxicity and inflammatory response level are maintained.

1. The name of the design product: packing box (sildenafil citrate tablet). 2. The use of the design product: for packing articles. 3. The design points of the design product: the combination of shape and pattern. 4. The picture or photo best indicating the design points: perspective view.

The present application relates to the technical field of health product ingredient detection, in particular to a detection method of a new type of sildenafil compound in health food, comprising the following steps: qualitative and quantitative detection by HPLC-MS / MS; the chromatographic conditions include: a chromatographic column, a C18 column; a column temperature, 40 DEG C; a mobile phase A, 0.1% formic acid aqueous solution; a mobile phase B, acetonitrile; a flow rate, 0.5 mL / min; a gradient elution program, 0~2.0 min, 10%B~95%B; 2.0~5.0 min, 95%B; 5.0~5.1 min, 95%B~5%B; 5.1~8.0 min, 5%B; a sample injection amount, 5 µL; the mass spectrometry conditions include: an ionization mode, an electrospray ionization source, a positive ion mode; an electrospray voltage, 5500 V; an ion source temperature, 550 DEG C; an atomization gas pressure, 345 kPa; an auxiliary gas pressure, 414 kPa; a curtain gas pressure, 276 kPa; a declustering voltage, 100 V; a collision energy, 45 V; a quantitative ion pair, 449 / 243; a qualitative ion pair, 449 / 259; the residence time of each ion pair, 250 ms; the new type of sildenafil compound contains a methyl piperazine group. The detection method of the present application is simple in operation, short in time consumption, high in sensitivity and good in stability.

1. Name of the designed product: packing box (sildenafil citrate tablet Langmei). 2. Use of the designed product: the designed product is used for packing and protecting medicine. 3. Design points of the designed product: the pattern. 4. Picture or photo best indicating the design points: perspective view.

1. The name of the design product: packaging box (sildenafil hydrochloride tablets). 2. The use of the design product: for packaging medicines. 3. The design points of the design product: the combination of shape and pattern. 4. The picture or photo that best indicates the design points: design 1 unfolded state diagram. 5. Design 1 is designated as the basic design. 6. Other circumstances that need to be explained: The six views and the unfolded state diagram of the product are sufficient to explain the design points of the design, so the design 1 perspective and design 2 perspective are omitted.

The invention relates to nano hydrogel for treating diabetic chronic ulcer as well as a preparation method and application of the nano hydrogel. The nano hydrogel comprises a drug nano aggregate formed by sildenafil citrate and glycosylated naringin serving as a solubilizer and an antioxidant through molecular self-assembly, the hydrogel matrix is formed by crosslinking carboxymethyl chitosan and oxidized bletilla striata gum through a dynamic Schiff base reaction; wherein the drug nano aggregate is uniformly dispersed in the hydrogel matrix, and the drug nano aggregate and the hydrogel matrix jointly form the injectable and self-healing slow-release gel dressing. The method has the advantages that the hydrogel is formed through Schiff base reaction, conditions are mild, ultraviolet light or high temperature is not needed, and degradation of drugs and auxiliary materials is avoided. The gel process is rapid, and the formed gel has self-healing and injectable characteristics, can perfectly fit an ulcer wound surface with an irregular shape, and can automatically recover the structure after being damaged by shear force.

The invention focuses on developing final ophthalmic dosages based on Sildenafil associated with bevacizumab, known for its retino-protective properties, aimed to preserve and improve visual functions, particularly in patients with retinal degenerative disease specially for the dry form of macular degeneration

The invention relates to the technical field of biological medicine. The invention provides an application of sildenafil in preparation of a product for inhibiting adipogenic differentiation of mesenchymal stem cells. The use concentration of the sildenafil is 5-20 mg / L. The sildenafil with the concentration can remarkably inhibit the adipogenic differentiation effect of mesenchymal stem cells, and possibly inhibits the expression of adipogenic related genes by regulating a PI3K-AKT signal channel, so that bone marrow adipogenesis is reduced, the bone microstructure is improved, and osteoporosis and other diseases related to excessive adipogenic differentiation are improved. A new thought and application value are provided for reutilization of sildenafil in bone metabolism regulation and stem cell differentiation directions.

The invention provides a novel pharmaceutical composition comprising a phosphodiesterase type 5 (PDE5) inhibitor other than sildenafil and a dopamine agonist and method of use thereof for treating erectile dysfunction and / or male hypogonadism.

The application belongs to the technical field of microorganisms and their application, and specifically discloses a mucinophilic Akkermansia strain, a high-activity reserved inactivation method of the strain and application of the strain. The strain has a preservation number of CGMCC No. 33955, and when the strain is cultured in a mucin only carbon source culture medium for 48 hours, the OD600 value reaches 1.32 and the acetic acid yield is 18.3 mmol / L. The inactivation method uses a solution containing sulfated dextran, sucrose and epsilon-polylysine as a composite protective agent, and after the solution is mixed with the bacterial solution, the mixture is incubated at 45 DEG C to 50 DEG C for 16 min to 20 min. The inactivated strain reduces inflammation and protects lung vascular function through the "gut-lung axis", and in a MCT-induced PAH rat model, the intervention effect is close to sildenafil, and there is no increase in liver enzymes, the serum TNF-alpha and IL-6 are reduced, and the problems of large side effects and low activity reservation of existing PAH intervention are solved.

1. Name of the designed product: packing box (sildenafil citrate tablet). 2. Use of the designed product: for product packing. 3. Design points of the designed product: combination of shape and pattern. 4. Picture or photo best indicating the design points: perspective view 1.

There is provided a composition for topical application to the penis to treat erectile dysfunction wherein the composition is free of glyceryl trinitrate (GTN), sildenafil and an acetylcholin esterase inhibitor, but comprises volatile and non-volatile solvents, the volatile solvent comprising a lower alcohol and water, the non-volatile solvent comprising a polyol and a diol. Preferably, the composition is free of any pharmaceutically active ingredient for the treatment of erectile dysfunction. Also provided is a method of determining the cooling capacity of a test composition (e.g., the above composition).

1. Name of the product in this design: Packaging Box (Sildenafil Citrate Tablets 7). 2. Purpose of this design: This design is used for the packaging and protection of pharmaceuticals. 3. The key design feature of this product is its pattern. 4. The image or photograph that best illustrates the design's key points: a 3D model.

The invention provides an aldenafil citrate orally disintegrating tablet as well as a preparation method and application thereof. The aldenafil citrate orally disintegrating tablet comprises the following components: a pharmaceutical active component, an auxiliary carrier, a disintegrating agent, a filling agent, a flavoring agent, an adhesive and a lubricant, the active pharmaceutical ingredient comprises aldenafil citrate and / or a pharmaceutically acceptable salt thereof; the auxiliary carrier comprises any one or a combination of at least two of a water-soluble vitamin E derivative, an organic acid or an organic acid salt. The adenafil citrate orally disintegrating tablet provided by the invention has better taste, is convenient to take, does not need water, can be quickly disintegrated in the oral cavity, the disintegration time limit does not exceed 60 seconds, the maximum plasma concentration time does not exceed 1 hour, and the requirement that the adenafil citrate needs to take effect quickly under specific conditions is met.

The application discloses a new use of sildenafil and its salts in combination with ibuprofen. Through pharmacodynamics and toxicology experiments, the application first proposes and verifies that the combination of sildenafil and its salts (sildenafil citrate) and ibuprofen has a significant synergistic effect in treating inflammatory pain, and can effectively reduce the renal toxicity induced by long-term administration of ibuprofen. The application solves the problem that long-term or large-dose use of ibuprofen can induce significant renal toxicity, which seriously limits the long-term, standard and sufficient clinical application of ibuprofen. The composition provided by the application can enhance the analgesic effect of ibuprofen and reduce the renal toxicity of ibuprofen, and has important clinical conversion value and practical application prospect.

The invention discloses a sildenafil citrate orally disintegrating tablet and a preparation method thereof, and the sildenafil citrate orally disintegrating tablet comprises the following components in parts by weight: 68-75 parts of sildenafil citrate, 300-320 parts of mannitol, 15-19 parts of polyvinylpolypyrrolidone, 55-75 parts of polyvinyl acetate aqueous dispersion, 20-35 parts of a disintegrating agent, 20-35 parts of a filler, 3-6 parts of a flow aid and 2-5 parts of a coloring agent. 5-20 parts of a flavoring agent, 5-20 parts of an aromatic and 5-20 parts of a lubricant. According to the product disclosed by the invention, the dissolution rate is improved, the bitterness of the preparation is covered, the taste and smell of the product are improved, the stability of the product and the compliance of a patient are improved, and the production cost is reduced.

1. The name of the design product: packaging box (sildenafil citrate tablets 6). 2. The use of the design product: the design product is used for the packaging and protection of medicines. 3. The design points of the design product: in the pattern. 4. The picture or photo that best indicates the design points: perspective view.

The invention relates to sildenafil-coix seed oil nano-lipid gel as well as a preparation method and application thereof. The nano-lipid hydrogel is formed by uniformly dispersing nano-liposomes in a hydrogel matrix, the nanoliposome is composed of sildenafil, coix seed oil and solid lipid, and the pH value of the hydrogel matrix is in the range of 6.5-7.0; the average particle size of the nano-liposome is 80-100 nm, and the encapsulation efficiency is not lower than 90%. The invention has the following advantages: SC, as a PDE-5 inhibitor, can indirectly inhibit ROS generation by up-regulating a NO-cGMP pathway, reduce DNA damage, and promote vasodilation, collagen deposition and reepithelization; the CSO is rich in unsaturated fatty acid, can directly remove. OH / DPPH free radicals and is inserted into a keratinocyte interlayer to repair a membrane barrier function, and the CSO and the CSO synergistically exert anti-inflammatory and anti-oxidation effects in radiation damage.

The present application relates to the technical field of drug detection, and particularly relates to a detection method of sildenafil citrate tablets, which comprises the following steps: S1, placing contents with different water contents and a target sample in a plurality of containers; S2, determining the drug concentration of each region based on the image color development characteristics of the target sample after diffusion in the containers at different detection time points, and calculating the concentration gradient component and the diffusion concentration gradient of the target sample; S3, measuring the total amount or concentration of the remaining drug in the target sample in the containers within a preset time period, so as to determine the residual degree of the target sample; and S4, determining the diffusion difference degree based on the diffusion concentration gradient and the residual degree, and evaluating the diffusion adaptability of the target sample based on the diffusion difference degree. The present application not only improves the accuracy and depth of the research on the diffusion performance of drugs, but also further provides reliable data support for the research and quality control of drugs, and helps to improve the quality of drugs.

The invention belongs to the field of pharmaceutical preparations, and provides a Chinese and western medicine combined male function improving composition and a preparation method thereof. According to the invention, three active components, namely sildenafil citrate, icariin and fried Chinese chive seed powder, are synergistically designed, the sildenafil citrate and icariin are used for preparing clathrate compound powder through a beta-cyclodextrin clathrate solubilizing technology, the fried Chinese chive seed powder is micronized and then dispersed in a film forming solution under the wetting action of polysorbate 80, and the film forming solution is prepared into the sildenafil-icariin clathrate compound. A hydroxypropyl methylcellulose-sodium carboxymethyl cellulose double-polymer film base material system and a citric acid-trisodium citrate buffer stable system are combined, so that the technical problems that a multi-component system is poor in film forming uniformity under high solid content load, the mechanical integrity of the film is insufficient, and instant release and structural stability are difficult to consider at the same time are solved; the traditional Chinese medicine composition has the advantages of convenience in taking, quick response and high bioavailability, and is suitable for improving male functions.

The invention discloses an application of sildenafil in preparation of an anti-aging drug. According to the application disclosed by the invention, sildenafil is found to be capable of effectively inhibiting senescence of microglial cells, reducing the expression of cell senescence markers p21, gamma H2Ax, p16 and H3k9me3, and recovering the expression of Lamin B1 and pRb. In a mouse in-vivo experiment, sildenafil can be used for remarkably improving cognitive impairment and learning and memory ability damage caused by aging and reducing the transcription expression level of inflammatory factors Mcp1, Tnf, Il1a and Il1b. In conclusion, the inventor puts forward that anti-aging is a brand-new adaptation disease of sildenafil, and sildenafil can be used for preparing anti-aging drugs.

The application discloses a use of sildenafil in preparation of an anti-breast cancer drug in combination with tamoxifen, and sildenafil can promote the entry of GAPDH into a nucleus and inhibit the proliferation of tamoxifen-resistant cells (MCF-7TR). The application also discloses an anti-breast cancer drug composition which can inhibit the proliferation of breast cancer tamoxifen-resistant cells (MCF-7TR) and thus reverse the sensitivity of the drug-resistant cells to tamoxifen, and the composition comprises sildenafil and tamoxifen. The application utilizes the targeted reversing effect of sildenafil on breast cancer cells resistant to tamoxifen, so that the breast cancer tamoxifen-resistant cells can be restored to be sensitive to tamoxifen, and a more economical, convenient and effective treatment option is brought to tumor patients.

The application belongs to the field of pharmaceutical preparations, and particularly relates to a new sildenafil oral dissolving film composition, which comprises sildenafil or a pharmaceutically acceptable salt thereof, a film-forming material, a disintegrant, a plasticizer, a stabilizer and other pharmaceutically acceptable excipients, wherein the film-forming material is a combination of polyvinyl alcohol and hypromellose, and the stabilizer is a small-molecule organic acid. The sildenafil oral dissolving film composition has good film-forming effect, effectively controls the generation and growth of sildenafil impurities, particularly oxidation impurity B, and has good preparation stability.