The present invention provides methods for treating a variety of urogenital disorders, such as, for example, vaginismus, dyspareunia, vulvodynia (including vulvar vestibulitis),
interstitial cystitis, nonspecific urethriris (i.e., nonspecific pain and / or burning of the urinary tract) and sexual dysfunctions, such as, for example, female
sexual arousal disorders and female sexual orgasmic disorders, using a variety of compounds, including, but not limited to,
NO donors,
calcium channel blockers,
cholinergic modulators, α-
adrenergic receptor antagonists, β-
adrenergic receptor agonists,
phosphodiesterase inhibitors, cAMP-dependent
protein kinase activators (e.g., cAMP mimetics),
superoxide scavengers,
potassium channel activators,
estrogen-like compounds,
testosterone-like compounds, benzodiazepines,
adrenergic nerve inhibitors, antidiarrheal agents, HMG-CoA
reductase inhibitors,
smooth muscle relaxants,
adenosine receptor modulators,
adenylyl cyclase activators, endothelin receptor antagonists, bisphosphonates and cGMP-dependent
protein kinase activators (e.g., cGMP mimetics).