399 results about "Ethoxidine" patented technology

The present invention relates to novel (3,3-dimethyl-2-oxo-butoxy)phenyl derivatives and (2- aryl-2-oxo-ethoxy]phenyl derivatives and to their application in a process for the preparation of (3,3,3-trifluoro-2-oxo-propoxy)phenyl derivatives and their further transformation into [(2- trifluoromethyl-1,3-dioxolan-2-yl)methoxy]phenyl derivatives and (2-ethoxy-3,3,3-trifluoro- prop-1-enoxy)phenyl derivatives suitable for use, e.g., as active ingredients, which have microbiocidal activity, in particular, fungicidal activity.

The invention relates to a method for continuously synthesizing a dapagliflozin intermediate, and belongs to the technical field of drug intermediate synthesis. The method comprises the following steps: mixing 5-bromo-2-chloro-4 '-ethoxydiphenylmethane, a photocatalyst and THF (tetrahydrofuran), introducing the mixture into an ultraviolet light catalytic micro-channel for pre-activation to generate an aryl free radical intermediate, namely a pre-activation solution, carrying out contact reaction on the pre-activation solution and a THF solution of 2, 3, 4, 6-tetra-O-trimethylsilyl-D-glucolactone in a low-temperature coupling area of a micro-reactor, and carrying out purification, purification and purification to obtain the aryl free radical intermediate. The reaction liquid is introduced into a dynamic quenching zone and is mixed with supercritical CO2 on line, an intermediate I is obtained through supercritical fluid extraction and separation, and the photocatalyst is recycled; the method has the advantages of high reaction efficiency, convenience in catalyst recovery and simplicity in product separation.

An active energy ray-curable inkjet printing ink composition satisfies requirements A to E below is provided: (A) the content of amine-modified oligomer is 1.0 to 20.0% by mass; (B) alkoxy group-containing (meth)acrylate monomers are contained by 2.0 to 20.0% by mass; (C) (meth)acrylate monomers having an alkyl group with 6 to 20 carbon atoms is contained by 2.0 to 25.0% by mass; (D) at least one type selected from the group that consists of 1,6-hexanediol diacrylate, 3-methyl-1,5-pentanediol diacrylate, dipropylene glycol diacrylate, 1,10-decanediol diacrylate, propoxylated(2)neopentyl glycol diacrylate, and hydroxypivalic acid neopentyl glycol diacrylate is contained by 30.0 to 60.0% by mass; (E) as photopolymerization initiators, ethoxy(2,4,6-trimethylbenzoyl)phenylphosphine oxide is contained by 3.0 to 15.0% by, and oligo(2-hydroxy-2-methyl-1-(4-(1-methylvinyl)phenyl)propanone) and / or 2-hydroxy-1-{4-[4-(2-hydroxy-2-methylpropionyl)phenoxy]phenyl}-2-methylpropanone is / are contained by 2.0 to 10.0% by mass, where the total content of photopolymerization initiators is 6.0 to 25.0% by mass.

The invention relates to the technical field of fabric waterproofing agents, in particular to a polyurethane modified organic silicon fluoride-free waterproofing agent and a preparation method thereof. The polyurethane modified organic silicon fluoride-free waterproof agent is prepared from the following raw materials in parts by mass: 5 to 15 parts of hexamethylene diisocyanate, 5 to 15 parts of butyl acrylate, 1 to 5 parts of methyl methacrylate, 40 to 60 parts of octamethylcyclotetrasiloxane, 10 to 30 parts of alpha, omega-dihydroxy polydimethylsiloxane and 5 to 10 parts of gamma-aminopropyl methyl diethoxy silane. The invention relates to a silane coupling agent, which is prepared from the following raw materials in parts by weight: 1 to 5 parts of glycidyl ether oxypropyl trimethoxy silane, 0.1 to 1 part of tetramethylammonium hydroxide, 0.1 to 1 part of triethylamine, 2 to 5 parts of tetraethoxysilane, 0.2 to 0.75 part of ammonia, 0.1 to 1 part of silane coupling agent KH-570, 0.01 to 0.1 part of dibutyltin dilaurate, 1 to 5 parts of epsilon-caprolactam, 1 to 2 parts of emulsifier and 0.1 to 1 part of initiator. The fabric treated by the method has good softness and excellent hydrophobic effect.

The invention belongs to the technical field of cosmetics, and discloses a superconductive centella asiatica extract as well as a preparation method and application thereof. The superconductive centella asiatica extract has a core-shell structure, an inner core of the superconductive centella asiatica extract comprises centella asiatica extract, a shell of the superconductive centella asiatica extract comprises ionic liquid, and the ionic liquid comprises ethyoxyl diglycol, urea, betaine, N-ethyl pyrrolidone and hydroxyethyl piperazine ethanesulfonic acid. According to the invention, ethyoxyl diglycol, urea, betaine, N-ethyl pyrrolidone and hydroxyethyl piperazine ethanesulfonic acid are compounded to obtain the ionic liquid, and the centella asiatica extract is wrapped in the ionic liquid, so that the stability, transdermal absorption rate and bioavailability of the centella asiatica extract can be effectively improved.

The invention provides a preparation method of 1-(3-bromo-4-(2-fluoro [18F] ethyoxyl) ethyoxyl) benzyl guanidine (called 18F-TTRC01) and application of the 1-(3-bromo-4-(2-fluoro [18F] ethyoxyl) ethyoxyl) benzyl guanidine in the field of neuroendocrine tumor diagnosis. The compound is synthesized through the following route. According to the invention, a brand new initial raw material and a preparation route are adopted, a large dose of 18F ions are used for labeling, and an automatic synthesis mode is adopted to successfully prepare the 18F-TTRC01, so that the reaction time is greatly shortened, and the radiation dose to operators is reduced. The obtained 18F-TTRC01 injection can be used for diagnosis and curative effect evaluation of neuroendocrine tumors, and has an outstanding clinical effect. # imgabs0 #

The present invention relates to a process for the preparation of (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide of formula (I) and to the preparation and use of crystalline modification I of (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide of formula (I).

The present invention relates to a process for preparing acyloxymethyl esters of (4S)-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylic acid of the formula (IIa) by optical resolution of the compound of the formula (II) using a hydrolase. The invention also relates to a process for preparing (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide of the formula (Ia), wherein the process comprises the optical resolution of the compound of the formula (II) using a hydrolase. The invention additionally also relates to the use of a hydrolase in a process for preparing a compound of formula (IIa). The invention further relates to the use of a hydrolase in a process for preparing a compound of formula (Ia).

This invention relates to N-(3-(6-Amino-5-(2-(N-methylacrylamido)ethoxy)pyrimidin-4-yl)-5-fluoro-2-methylphenyl)-4-cyclopropyl-2-fluorobenzamide drug substance substantially free of a nitrosamine impurity, e.g. the nitrosamine impurity N-(3-(6-amino-5-(2(methyl)(nitroso)amino)ethoxy)pyrimidin-4-yl)-5-fluoro-2-methylphenyl)-4-cyclopropyl-2-fluorobenzamide and novel processes of preparation thereof. The invention further relates to pharmaceutical composition comprising N-(3-(6-Amino-5-(2-(N- methylacrylamido)ethoxy)pyrimidin-4-yl)-5-fluoro-2-methylphenyl)-4-cyclopropyl-2-fluorobenzamide, wherein the composition is substantially free of a nitrosamine impurity, e.g. the nitrosamine impurity N-(3-(6-amino-5-(2(methyl)(nitroso)amino)ethoxy)pyrimidin-4-yl)-5-fluoro-2-methylphenyl)-4-cyclopropyl-2-fluorobenzamide. Pharmaceutical products containing said drug substance and compositions are also disclosed, as well as methods for preparing said drug substance, pharmaceutical compositions and products.

The invention relates to the field of synergists, aims to solve the problems of crop phytotoxicity, environmental pollution and the like possibly caused by application of excessive herbicides, and provides a synergist which comprises the following components in parts by weight: 50-55 parts of ammonium sulfate, 27-37.5 parts of anhydrous sodium sulfate, 8-10 parts of a dispersing agent, 3-5 parts of potassium fulvate, 1-2 parts of a wetting agent and 0.5-1 part of ethyoxyl modified trisiloxane. The synergist obtained by compounding the raw materials can effectively improve the use effect of the herbicide; the dispersing agent can form a protective film on the surfaces of pesticide particles, so that the pesticide particles are prevented from being broken or agglomerated due to mutual collision, the surface tension between water and pesticide powder is reduced, and the solubility and stability of the pesticide are enhanced; ethyoxyl modified trisiloxane can promote pesticide components to be spread on the surfaces of plants quickly and uniformly, promote the pesticide components to permeate into the plants and accelerate the conduction effect of the plants, so that the effect of the pesticide is greatly improved; the growth promoter can promote the absorption of the plant to the pesticide and the conduction of the pesticide in the plant body.

The invention belongs to the technical field of flame-retardant master batches, and particularly relates to a flame-retardant master batch for polypropylene and a preparation method thereof.The preparation method comprises the steps that tris (2-hydroxyethyl) isocyanurate is heated and molten, tetrabutyl titanate and DOPO-DPP are added into the molten tris (2-hydroxyethyl) isocyanurate, the mixture reacts for 3-4 h, melamine and cyanuric acid are added into the molten tris (2-hydroxyethyl) isocyanurate, the mixture reacts for 30 min, cooling and smashing are conducted, and a macromolecular flame retardant TDMC is obtained; the preparation method comprises the following steps: carrying out ester exchange reaction on 2, 4-diphenyl-6-[2-hydroxy-4-(ethoxycarbonyl methoxy) phenyl]-1, 3, 5-triazine and 2, 2, 6, 6-tetramethyl piperidinol to prepare a free radical capturing agent; the polypropylene, the TDMC, the free radical scavenger and the zeolite are put into a high-speed mixer to be stirred and mixed, and then extrusion granulation is performed. The macromolecular flame retardant TDMC is adopted, the molecular weight of the macromolecular flame retardant TDMC is large, the water resistance is good, and the compatibility and damp-heat stability of the flame-retardant master batch in polypropylene are improved.

The invention discloses a molecular sieve catalyst for synthesizing methyl ethyl carbonate by a transesterification method and a regeneration method, and relates to the technical field of molecular sieve catalysts, the molecular sieve catalyst comprises a microporous double-active-center inner core and an amphoteric mesoporous shell; the microporous double-active-center core takes the X-type zeolite as a carrier to load potassium, cesium, lanthanum and barium; the amphoteric mesoporous shell is an MCM-41 and SBA-15 composite mesoporous silica layer coating the outer part of the inner core and has a double-mesoporous structure, amino propyl triethoxy silane and carboxyethyl triethoxy silane are grafted on the surface of the amphoteric mesoporous shell, and zirconium and titanium are co-doped. According to the invention, collaborative optimization of active centers and mass transfer channels is realized through a core-shell structure of a microporous double-active-center core and an amphoteric mesoporous shell. The activity and selectivity of catalytic transesterification are remarkably improved by the microporous core; due to the double-mesoporous structure and surface functional modification of the amphoteric mesoporous shell, the mass transfer efficiency of reactants and products is improved, and the adaptability of the catalyst to a reaction system is enhanced.

The invention relates to a high-selectivity amine-process absorbent and a preparation method thereof, and belongs to the technical field of industrial desulfurization. The absorbent comprises a main absorbent, an organic sulfur removal accelerant, an auxiliary agent and deionized water, the main absorbent comprises alcohol amine containing a tertiary amine structure and / or steric hindrance; the alcohol amine containing the tertiary amine structure and / or the steric hindrance comprises one or more of methyldiethanolamine, diisopropanolamine, 2-(tert-butylamino) ethanol, tert-butylamino ethoxyethanol and 2-amino-2-methyl-1-propanol. According to the method, CO2 absorption is inhibited through the steric hindrance amine, the regeneration energy consumption is reduced by 40%, and the technical problems that in the prior art, the CO2 co-absorption rate is high, and the regeneration energy consumption is large are solved.

The present disclosure provides a unit dose product comprising a pouch formed from a water-soluble film material; and a detergent composition comprising about 5 to about 20 wt % water, about 35 to about 65 wt % of at least one surfactant, and a non-aqueous solvent, wherein the detergent composition is disposed within the pouch. The composition can further comprise additional components, such as a base, a performance polymer, an anti-redeposition agent, an enzyme, a bleaching agent, a bleach activator, a chelating agent, an optical brightener, a bitterant, a corrosion inhibitor, or a combination thereof. The detergent composition comprises surfactants with improved mildness and solvents with lower allergic components.

The present invention belongs to the technical field of the prevention and removal of ice, and specifically relates to a coating having a good durability and being capable of preventing and removing ice in a large area, and a preparation method therefor and the use thereof. The preparation method of the present invention comprises: firstly, adding an SiO2 dispersion to an elastomer prepared from PDMS and a normal-temperature curing agent, and mixing same until uniform to obtain a coating solution, wherein the PDMS has a viscosity of 3,000-4,000 Pa·s and a molecular weight of 120,000-130,000; and the normal-temperature curing agent is a normal-temperature curing agent containing no carbon-carbon triple bond, and comprises one of methyltriethoxysilane, methyltripropoxysilane, diphenylbutyl carbamate or dibenzoyl peroxide.

The application relates to the technical field of chemical synthesis, in particular to a synthesis method of a key intermediate of pentconazole, which comprises the following steps: S1, Witting-Horner reaction of 2,4-dichlorobenzophenone and (diethoxy) phosphoethyl acetate under the action of a strong base to generate 3-(2,4-dichlorophenyl)-2-en-hexanoic acid ethyl ester; S2, Prilezhaev epoxidation reaction of 3-(2,4-dichlorophenyl)-2-en-hexanoic acid ethyl ester and meta-chloro peroxybenzoic acid to generate 3-(2,4-dichlorophenyl)-2,3-epoxy-hexanoic acid ethyl ester; and S3, base hydrolysis and acidification of 3-(2,4-dichlorophenyl)-2,3-epoxy-hexanoic acid ethyl ester to obtain a key intermediate 2-(2,4-dichlorophenyl) pentanal of pentconazole. The application has the effects of higher reaction yield, lower toxicity of reaction raw materials and more gentle reaction conditions.

Disclosed in the present invention is a monodisperse nanocalcium carbonate-based foliar calcium fertilizer, comprising the following raw materials in parts by mass: 1-20 parts of a monodisperse nanocalcium carbonate filter cake, 0.05-0.9 parts of ethoxy-modified polytrisiloxane, 0.01-0.8 parts of modified casein, 0.01-0.8 parts of an enzyme, 0.05-0.9 parts of a sugar alcohol, and 10-180 parts of water. After being diluted by means of water such that the solid content of calcium carbonate is 0.5-2%, the foliar calcium fertilizer is used for foliar calcium supplementation of various crops and fruit and vegetable crops. The novel foliar calcium fertilizer is safe and non-toxic, can be directly sprayed onto foliar and fruit surfaces of crops and fruits and vegetables, effectively ensures calcium absorption and utilization in crops, achieves the effect of increasing yield and increasing income, and can also improve the yield of fruits and vegetables.

The application discloses a preparation method of a key intermediate of dapagliflozin, and belongs to the technical field of preparation of medical intermediates. The preparation method of the key intermediate of dapagliflozin comprises the following steps: 1, 1-ethoxy-4-methylbenzene is prepared by using p-cresol, sodium hydroxide and diethyl sulfate; 2, (4-ethoxybenzyl) phenyl sulfide is prepared by using 1-ethoxy-4-methylbenzene, thiophenol, a palladium catalyst, an alkali and an oxidant; 3, 1-benzyl-4-ethoxybenzene is prepared by using (4-ethoxybenzyl) phenyl sulfide under a hydrogen atmosphere; 4, 4-ethoxy-2'-chlorobenzhydrol is prepared by carrying out chlorination reaction on 1-benzyl-4-ethoxybenzene; and 5, 5-bromo-2-chloro-4'-ethoxybenzhydrol is prepared by carrying out bromination reaction on 4-ethoxy-2'-chlorobenzhydrol. The yield and purity of 5-bromo-2-chloro-4'-ethoxybenzhydrol prepared by the method are higher, the process is safer, and the production cost is reduced.

The invention discloses a synthesis method of 4-bromo-3-(ethoxymethyl) benzoic acid, which comprises the following steps: (1) activating carboxyl of p-bromobenzoic acid serving as a raw material in the presence of an organic anhydride activator, and then performing chloromethylation reaction with paraformaldehyde in the presence of a chlorine-containing Lewis acid catalyst to obtain 4-bromo-3-(ethoxymethyl) benzoic acid; after the reaction is completed, carrying out post-treatment to obtain an intermediate 4-bromo-3-(chloromethyl) benzoic acid; and (2) carrying out nucleophilic substitution reaction on the intermediate obtained in the step (1) in ethanol under the action of inorganic alkali to prepare the target product 4-bromo-3-(ethoxymethyl) benzoic acid. According to the invention, through one-pot activation and chloromethylation of p-bromobenzoic acid, concise, efficient and highly economical synthesis from cheap raw materials to the sparsentan key intermediate is realized.

The present invention relates to polymorphs of the hydrochloride salt of 5-{2-[({8-[(2,6-dimethylbenzyl)amino]-2,3-dimethylimidazo[1,2-a]pyridine-6-yl}carbonyl)-amino]ethoxy}-5-oxopentanoic acid (linaprazan glurate), more specifically Form 1 and Form 2 of the HCl salt of linaprazan glurate. The invention also relates to a process for the preparation of such polymorphs, to pharmaceutical compositions comprising such polymorphs, and to the use of these polymorphs in the treatment or prevention of gastrointestinal inflammatory diseases or gastric acid related diseases, in particular erosive gastroesophageal reflux disease (eGERD).

This invention discloses a yam oxylipoic acid compound with aromatase inhibitory activity, its application, and analytical identification methods, belonging to the field of medicinal chemistry. The yam oxylipoic acid compound is (Z)-9-ethoxy-6,10-dihydroxyoctadec-7-enoic acid, a novel compound. This compound can significantly inhibit aromatase activity and possesses the ability to inhibit excessive estrogen production, thus showing promising application prospects and value in diseases related to estrogen imbalance regulation.

The invention discloses an in-situ synthesis method and application of a dysprosium complex of quinazolinone Schiff base. The complex is prepared by a low-temperature solvothermal method in a methanol solvent using N'-(3-ethoxysalicylidene)-2-(3-ethoxysalicylideneimine) benzohydrazide and dysprosium nitrate as reaction raw materials. During the reaction process, part of the initial ligand is in-situ transformed into 3-(3-ethoxysalicylideneimine) quinazolinone. The initial ligand and the in-situ generated quinazolinone Schiff base ligand jointly construct an unprecedented dysprosium-based pentanuclear cluster structure formed by the sharing of edges of {Dy4} tetrahedral units and {Dy3} triangular units. Under zero external field, the complex exhibits obvious single-molecule magnet behavior characteristics and has application potential in the field of new molecular-based magnetic materials.

Disclosed is a method for preparing oxetan-2-ylmethanamine, which belongs to the field of organic synthesis. [2-(1-ethoxyethoxy)methyl]propylene oxide is used as an initial raw material, and reacted in the presence of potassium tert-butoxide and trimethylsulfoxonium iodide; the resulting product is reacted with a sulfonyl compound and triethylamine; the resulting product is reacted with a compound of phthalimide; the resulting product is reacted with an amino group-containing compound, to obtain oxetan-2-ylmethanamine. The method according to the disclosure allows for an overall yield of not less than 30% in scale-up production (kilogram level), which is higher. Moreover, compared with the traditional method for preparing oxetan-2-ylmethanamine, a palladium-carbon catalytic hydrogenation step is not required, and dangerous chemical-sodium azide is not required in the method according to the disclosure. Thus, the method has high safety, low production cost, simple operations, and thereby is suitable for industrial production.

The invention relates to the technical field of chemical synthesis, and particularly discloses a compound with a peculiar smell removing function as well as a preparation method and application thereof. The chemical name of the compound is 2-ethoxy-3-((E)-methoxy-3-oxopropyl-1-alkene-1-yl) phenyl cinnamate, the smell of the compound is extremely light, sulfur-containing and nitrogen-containing compounds causing stink can be captured through a Michael addition reaction, and efficient peculiar smell removal is achieved. The preparation method comprises the following steps: (1) taking cinnamic acid as an initial raw material, and reacting with diethylamino sulfur trifluoride to prepare cinnamic acid acyl fluoride; (2) carrying out an esterification reaction on the cinnamic acid acyl fluoride and 2-methoxy-3-hydroxybenzaldehyde in the presence of 4-dimethylaminopyridine, so as to obtain 2-methoxy-3-formyl phenyl cinnamate; and (3) carrying out Wittig reaction on the 2-methoxy-3-formyl phenyl cinnamate and a phosphorus ylide reagent, so as to obtain the target compound.

The invention discloses a preparation method of a dapagliflozin intermediate 5-bromine-2-chlorine-4 '-ethyoxyl diphenylmethane, which comprises the following steps: carrying out nucleophilic substitution reaction on 4-bromine-1-chlorine-2-fluorobenzene and 4-ethyoxyl phenylacetate, and then hydrolyzing and decarboxylating to obtain the dapagliflozin intermediate 5-bromine-2-chlorine-4'-ethyoxyl diphenylmethane. By optimizing the preparation route, the reaction utilization rate, the product yield and the product purity of the raw materials are improved, high-risk and high-pollution chemicals are prevented from being used, and the method is convenient to operate, safe, environmentally friendly, efficient in reaction and beneficial to industrial implementation.

The invention relates to the technical field of pesticide production, and particularly discloses a preparation process of glufosinate-ammonium intermediate 3-(methyl hydroxyl phosphonyl) propionaldehyde. The preparation method comprises the following steps: 1, carrying out addition reaction on diethyl methylphosphonite and acrylic acid in absolute ethyl alcohol to generate 3-[ethyoxyl (methyl) phosphonyl] propionate; in the second step, 3-[ethyoxyl (methyl) phosphonyl] propionate is subjected to a hydrosilylation reaction in an oriented mode, and 3-triethyl siloxy-3-ethyoxyl propyl methyl ethyl phosphonate is generated; and 3, carrying out a simple dilute acid hydrolysis reaction to obtain the 3-(methyl hydroxyl phosphonyl) propionaldehyde. According to the method, a three-step reaction route of addition-hydrosilylation-hydrolysis is adopted, and the acrylic acid is used for replacing the traditional high-toxicity raw material acrolein, so that the toxicity risk is avoided from the source, the yield of the target glufosinate-ammonium intermediate is remarkably improved, the total yield of the three-step reaction can reach 95% or above, and the method is suitable for industrial production. And an efficient and green brand-new technical scheme is provided for large-scale production of glufosinate-ammonium.

This invention relates to a method for preparing the fenelone intermediate 2-cyanoethyl(4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthidine-3-carboxylic acid ester, and also relates to diastereomeric salts (Va), (Vb), (Vc), and / or (Vd). This method is simple to operate, and the diastereomeric salts can be obtained with very high chemical and enantiomeric purity (tartrate ester content <0.05%) through a single dissociation, avoiding the raw material loss and waste problems caused by multiple dissociations. It also has low production costs and meets the requirements of green production.

The present invention relates to the technical field of organic synthesis, and specifically to a method for synthesizing Fast Blue BB Salt. The method includes: (1) obtaining 1,4-dibromo-2,5-diethoxybenzene by bromination reaction of 1,4-diethoxybenzene; (2) reacting 1,4-dibromo-2,5-diethoxybenzene with benzamide to obtain N-(4-bromo-2,5-diethoxyphenyl)benzamide; (3) reacting N-(4-bromo-2,5-diethoxyphenyl)benzamide with trifluoroacetamide to obtain N-(2,5-diethoxy-4-(2,2,2-trifluoroacetylamino)phenyl)benzamide; and (4) obtaining Fast Blue BB Salt by hydrolysis of N-(2,5-diethoxy-4-(2,2,2-trifluoroacetylamino)phenyl)benzamide. The method has a short reaction route, mild reaction conditions, and meets the requirements of green and safe development.

The invention discloses a hydrophobic Zr-doped SiO2 (at) APTES-T composite aerogel desulfurization adsorbent as well as a preparation method and application of the hydrophobic Zr-doped SiO2 (at) APTES-T composite aerogel desulfurization adsorbent. The preparation method comprises the following specific steps: dissolving thiophene in n-heptane to form a non-polar template solution, and adding the non-polar template solution into a polar mixed solution of ZrOCl2, methyltriethoxysilane and 3-aminopropyltriethoxysilane, wherein water and ethanol serve as solvents of the ZrOCl2, the methyltriethoxysilane and the 3-aminopropyltriethoxysilane; the non-polar template solution is stirred in the polar solution to form uniform tiny liquid drops. The preparation method comprises the following steps: carrying out a hydrolysis-polymerization reaction on a mixed solution to form hydrophobic Zr-doped SiO2 (at) APTES-T alcogel, carrying out aging, replacement and drying steps to obtain the hydrophobic Zr-doped SiO2 (at) APTES-T composite aerogel desulfurization adsorbent, and applying the hydrophobic Zr-doped SiO2 (at) APTES-T composite aerogel desulfurization adsorbent to adsorption removal of thiophene compounds in simulated aromatic hydrocarbons. Results show that the desulfurization adsorbent disclosed by the invention has good adsorption performance on thiophene sulfides in aromatic hydrocarbons, has excellent performance of resisting competitive adsorption of polar impurities, and has good application prospects in the field of deep desulfurization.