63 results about "Sexual impotence" patented technology

The invention relates to haptoglobin or a nucleic acid encoding haptoglobin for use in treating or preventing of exaggerated erectile response and / or preventing permanent erectile dysfunction. In addition, the invention relates a pharmaceutical composition for use in treating or preventing exaggerated erectile response and / or preventing permanent erectile dysfunction, wherein the pharmaceutical composition comprises an adeno-associated viral (AAV) vector with a transgene encoding a haptoglobin gene. The exaggerated erectile response may be priapism, for example priapism associated with sickle cell disease (SCD).

An implantable system for treatment of climacturia has an inflatable penile implant and an inflatable cuff that is implantable around at least a portion of a urethra. A pump is operatively coupled to the penile implant and to the cuff to inflate the penile implant in treating erectile dysfunction and to inflate the cuff in treating climacturia.

This invention belongs to the field of traditional Chinese medicine, specifically relating to a topical delay spray and its preparation method. The invention uses the dried epidermis of the Huaxi toad (with the toad venom removed), and extracts it efficiently through a combination of water and alcohol extraction. Male silkworm moth oil can nourish and strengthen the body, tonify the liver and kidneys, and combat fatigue; studies have shown that male silkworm moth oil can effectively treat kidney yang deficiency. This invention combines the synergistic effects of toad skin extract and male silkworm moth oil to prepare a delay spray that can significantly treat premature ejaculation and erectile dysfunction in men. This preparation has the advantages of direct action, sustained release, avoidance of drug contact, and simple operation. This invention further improves the rational utilization system of toad resources, provides a practical solution for the efficient development of toad medicinal resources, and significantly reduces production and clinical application costs.

Microparticles that contain miRNA that controls the production of nitric oxide and are an agent for promoting the production of nitric oxide are new microparticles that enable controlling the expression of a protein and / or a gene related to erectile dysfunction; a preventive drug or a therapeutic drug for erectile dysfunction; a method for improving erectile dysfunction; it is preferable that the microparticles be exosomes; and it is preferable that the microparticles of the present invention contain miRNA targeting a gene concerning the expression of nitric oxide synthase as the miRNA that controls the production of nitric oxide, and be an agent for promoting the expression of nitric oxide synthase.

The invention discloses a preparation for treating erectile dysfunction caused by diabetes as well as a preparation method and application of the preparation. The invention firstly finds that a palmitoylation modification site, namely a 282 site, exists beside a 260 site in an Fbp1 functional region, and the site can be modified by the palmitoylation site to cause Fbp1 function damage. Therefore, point mutation modified Fbp1 mRNA of a C282S site is found and synthesized for the first time, namely cysteine of a 282 site is converted into serine, so that the Fbp1 is not subjected to Zdhhc13 palmitoylation modification and further is not subjected to function damage, lipid nanoparticles capable of targeted delivery of the modified Fbp1 mRNA are synthesized, and the C282S-Fbp1 mRNA loaded by the nanoparticles is infiltrated into a mouse cavernous body, so that the number of the Fbp1 is recovered, and the activity of the C282S-Fbp1 is improved. Therefore, the lactic acid concentration of the DMED penis cavernosum is effectively reduced, and the erectile function of a DMED mouse is remarkably improved.

The invention provides application of lactobacillus reuteri to improvement of prostatitis and erectile dysfunction. The bacterial strain is lactobacillus reuteri NHNK-2001, the lactobacillus reuteri NHNK-2001 is preserved in the China Center for Type Culture Collection on April 25, 2024, and the preservation number of the lactobacillus reuteri NHNK-2001 is CCTCC (China Center for Type Culture Collection) NO: M 2024800. The NHNK-2001 has the functions of generating L-citrulline, repairing aged vascular endothelial cells, promoting vasodilation, repairing aged prostate cells and reducing prostatitis, and can be used for preparing products for improving prostatitis and erectile dysfunction.

The present invention relates to a crystalline form I represented by Formula 1, which may be characterized by XRD patterns, DSC profiles, and / or TGA profiles, a method for preparing the same, and a pharmaceutical composition comprising the same, useful for the treatment of prevention of obesity, diabetes, inflammation, or erectile dysfunction. (see formula 1) wherein R1 is C2-C5 alkyl.

The application of the autologous dendritic cell in preparation of the medicine for treating the nerve injury erectile dysfunction can well promote recovery of the erectile function, perform staged reinfusion, induce immune regulation, repair nerve and blood vessel functions and improve a sex hormone regulation pathway. And the autologous dendritic cells are derived from a user, and have the advantages of safety, effectiveness and convenience in use. The combined immune cell therapy is obviously superior to a single treatment path in efficacy, is also more suitable for chronic, non-structural, subclinical and other ED people which are difficult to intervene by traditional methods, and has stronger individual adaptation ability and long-term controllability at the same time. Compared with a traditional scheme, the cell therapy targeting is better, and the treatment effect is faster.

To provide a new male climacteric disorder-ameliorating composition using a safe material free from side effects, and to provide a medicine, food and drink containing the composition.SOLUTION: The male climacteric disorder-improving composition contains a treated product of an Agaricus fruit body.SELECTED DRAWING: Figure 13

This invention discloses a traditional Chinese medicine composition for erectile dysfunction due to deficiency of both heart and spleen, and its application, belonging to the field of traditional Chinese medicine technology. The composition consists of a basic formula and modified formulas. The basic formula includes a spleen-tonifying and qi-boosting group, a heart-nourishing and blood-nourishing group, and a blood-activating and aphrodisiac group. The modified formulas are adjusted according to different concurrent symptoms. It can be prepared into various dosage forms such as decoctions and granules. This traditional Chinese medicine composition precisely addresses the core pathogenesis of erectile dysfunction due to deficiency of both heart and spleen—namely, "insufficient heart blood, deficiency of spleen qi, and malnourishment of the reproductive organs"—achieving spleen-tonifying and heart-nourishing, qi-boosting and blood-nourishing, and blood-activating and aphrodisiac effects, without causing stagnation or greasiness. Clinical trials have demonstrated definite efficacy, high overall effective rate, few adverse reactions, and low long-term recurrence rate. It can comprehensively improve patients' erectile function and accompanying symptoms, and is suitable for preparing drugs to treat erectile dysfunction due to deficiency of both heart and spleen.

The massage device using the fabric that is the article of the design is a massage device used in response to social needs, such as the need to treat erectile dysfunction through precise stimulation, alleviate insomnia and lower back pain, and prevent suicide through the euphoria caused by precise stimulation of the groin. This massage device is constructed by sewing together an outer fabric and an inner fabric with cushion holders, offset from each other to the left and right. The article has a pair of slits cut above and below the cushion holder in the outer fabric, and a pair of slits cut above and below the cushion holder in the inner fabric from the opposite direction to the outer fabric, allowing the cushion holder to be folded back between the pair of slits in the outer and inner fabrics. When the two cushion holders are folded back, an insertion opening is formed in the center. When used by a man, the penis is inserted into the insertion opening, the folded cushion is placed in close contact with the groin, and pressure is applied to the folded cushion, allowing for a groin massage.

This disclosure provides pharmaceutical compositions, such as compounds of formula Ib or formula IIb or their hydrates, spray-dried pharmaceutical compositions containing compounds of formula Ib or formula IIb or their hydrates, as well as methods for preparing and using the same, for the treatment and / or prevention of one or more of the following functional disorders or disorders: sexual dysfunction, erectile dysfunction, ejaculatory dysfunction, hypoactive sexual desire disorder, mental disorders, and neurological disorders. [Formula 1] TIFF2026529136000063.tif56109

The invention provides a traditional Chinese medicine composition for treating type 2 diabetic erectile dysfunction and a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicine compositions. The composition is prepared from radix bupleuri, radix paeoniae alba, radix rehmanniae preparata, Chinese yam, fructus corni, cortex moutan, poria cocos, rhizoma alismatis, herba cistanche, centipede, flos carthami, cortex eucommiae, radix angelicae sinensis and liquorice root. Clinical research proves that the total treatment effective rate of the traditional Chinese medicine composition reaches 78.13% which is obviously superior to 28.13% of a control group, the IIEF-5 score can be obviously improved, the traditional Chinese medicine symptoms can be improved, the effect on the aspects of improving sexual confidence and sexual nature indexes, reducing time worry and other psychological indexes is outstanding, and meanwhile the adverse drug reaction occurrence rate is not obviously different from that of the control group. The traditional Chinese medicine composition has the advantages of definite curative effect, integral regulation and simultaneous treatment of mind and body, and can be popularized and applied on a large scale.

To provide a new male climacteric disorder-ameliorating composition using a safe material free from side effects, and to provide a medicine, food and drink containing the composition.SOLUTION: The male climacteric disorder-improving composition contains a treated product of an Agaricus fruit body.SELECTED DRAWING: Figure 13

Provided is a method for treating disorders or conditions related to erectile dysfunction. The method includes administering to a subject in need thereof a therapeutically effective amount of mesenchymal stem cells or secretome thereof, wherein the mesenchymal stem cells or secretome are derived from human amniotic fluid.

The invention further relates to compounds, pharmaceutical compositions and methods for treating a subject for sexual function, such as sexual disorder or sexual dysfunction (SD), for inducing subject weight loss, for effectuating weight maintenance by a subject, whether or not the weight maintenance is used alone or in combination with a subject's weight loss, and / or for improving a subject's subjective state of well-being, self-esteem and / or self-confidence. Examples of SD contemplated by the present invention include but are not limited to female sexual disorder (FSD), female sexual arousal disorder (FSAD), female sexual interest / arousal disorder (FSIAD), female hypoactive sexual desire disorder (HSDD), female orgasmic disorder (FOD), female sexual pain disorder (FSPD), sexual interest arousal disorder (SIAD), male sexual disorder (MSD), male hypoactive sexual desire disorder (MSHDD), erectile dysfunction (ED), Pyronine's disease (PD), male premature ejaculation (MPE), male delayed ejaculation (MDE), male decreased libido (MDL), male dry orgasm (MDO).

The erectile dysfunction erection-assisting and sensitivity-reducing shield device comprises a shield device supporting piece and a simulation penis head connected with the front end of the shield device supporting piece. The shield device supporting piece is provided with a semi-open arc-shaped groove which partially wraps the cavernous body of the penis of a patient. A penis head cavity is formed in the joint of the simulated penis head and the shield device supporting piece, and the penis head located in the penis head cavity can be isolated from the female vagina. On the premise that normal experience of wives is guaranteed, erectile dysfunction patients can obtain proper sexual stimulation, so that the patients are helped to erect, and the problems of premature ejaculation and the like caused by excessive sexual stimulation can be well prevented. Moreover, the patient can adjust the degree of obtaining sexual stimulation and exercise the sensitivity of the penis through products of different models, and obtains better experience, so that the patient recovers the interest and confidence in sexual life. Through the physiological and psychological effects, the illness state of a patient is improved, the improvement of the good sensitivity of couples is facilitated, and the society is more harmonious.

A marker for characterizing an EPC subpopulation, an EPC subpopulation, and a use thereof. Indicators for distinguishing EPC subpopulations comprise CD144, vWF, CD133, or phagocytic capacity. On the basis of these indicators, identification, sorting, separation, or enrichment of EPC subpopulations can be achieved. Also provided are a use of late EPC in the preparation of a drug for treating stroke, erectile dysfunction, and ischemic diseases, and a method for treating stroke, erectile dysfunction, and ischemic diseases.

This invention relates to a restraint-free wearable intelligent sensing device and method for patients with erectile dysfunction (ED), belonging to the field of medical monitoring equipment and technology. The device includes an underwear-like main structure, a data acquisition unit, a micro-control module, a power supply module, and an electrical stimulation module. The underwear-like main structure has a data acquisition and monitoring area composed of multiple annular fiber sensing units arranged in a columnar elephant trunk structure. Each annular fiber sensing unit has an independent pressure-sensitive fiber sensing module. The data acquisition unit collects the wearer's pressure and temperature data in real time. The micro-control module is connected to the data acquisition unit to process and transmit the data collected. The method employs a multi-sensor signal processing stage algorithm and a cloud-based monitoring and closed-loop control stage algorithm. Based on the acquired loop-level monitoring data, it provides real-time feedback and prompts for adjustments, improving treatment convenience and personalization, and providing a more comprehensive, precise, and restraint-free solution for ED monitoring.

The invention provides a penis external supporting device and method for assisting male sexual dysfunction, and belongs to the technical field of medical instruments. The device comprises a sleeve-shaped main body made of a flexible biocompatible material and a built-in plastic deformation metal structure supporting piece, the front end and the rear end of the main body are provided with a first opening and a second opening respectively, the front end opening ensures that the glans penis is exposed to maintain sensitivity, and the internal metal supporting piece can be bent and shaped manually; after shaping, the bottom opening ensures that the ejaculation channel is not pressed, and the supporting force required for maintaining erection of the penis is provided. By means of the composite structure with the soft outer portion and the rigid inner portion and the humanized design with the two ends open, erection is effectively assisted, meanwhile, the physiological comfort level, sensitivity and the normal ejaculation function of a user are guaranteed to the maximum degree, and a safe, non-invasive and effective physical auxiliary instrument is provided for an erectile dysfunction patient.

A body implantable reservoir assembly has a reservoir body adapted to contain the liquid and an electronic assembly disposed in the reservoir body and adapted to move the liquid between the reservoir body and an implantable prosthesis. The electronic assembly has a printed circuit board and a battery hermetically sealed inside a canister, a pump assembly having a motor electrically coupled with the printed circuit board and the battery, a pump coupled with the motor, and a valve assembly coupled with the pump. When the reservoir body contains the liquid, the motor, the pump, and the valve assembly are immersed in the liquid.

The application discloses an external use delayed cream with natural ingredients and a preparation method thereof, belongs to the field of traditional Chinese medicine, and particularly relates to an external use delayed cream containing dry toad extract and toad oil and a preparation method thereof. The application is based on the local anesthetic properties of the dry toad extract and the toad oil, and an external use delayed cream is prepared by quantitatively controlling the dosages of the dry toad extract and the toad oil, which is used for treating male premature ejaculation and erectile dysfunction. The preparation has the advantages of direct action, sustained release and simple operation, and the preparation cost is low because the toad killed in breeding is used as a raw material. The application realizes the transformation of toad oil from waste to treasure, fully excavates the medicinal value of the toad oil, further perfects a reasonable utilization system of toad resources, and provides a practical scheme for efficient development of toad medicinal resources.

The present application provides a kind of male sexual function monitoring and behavior training control method and system, monitor the penile root, glans penis pressure value in sexual behavior training, calculate ejaculation latency;Penile tumescence degree value and glans penis tumescence degree value are calculated;Real-time current unit time sexual excitement degree value Ls is calculated, and according to the change of Ls, corresponding control mode is adopted, ejaculation time point, ejaculation latency and ejaculation latency number are extended.The present application can feed back the sexual excitement degree data of training to the trainer in real time, and according to the change of sexual excitement degree in training, the sexual excitement degree is promoted and controlled, and the ejaculation is controlled, for male sexual behavior training, extend the penile erection and ejaculation latency length, so as to continuously improve the ejaculation control of trainer, improve the brain ejaculation threshold, improve the penile blood vessel blood supply time, treat premature ejaculation, erectile dysfunction and other male sexual dysfunction.

The application belongs to the field of traditional Chinese medicine, and particularly relates to an external use delayed oil agent and a preparation method thereof. The dried skin of the Visternotus limnocharis which has scraped toad venom is combined with the male silkworm moth which has the functions of tonifying liver and kidney, strengthening yang and astringing essence to significantly improve male premature ejaculation and erectile dysfunction through water extraction and alcohol extraction. The male silkworm moth oil has unique promotion potential and development potential. The application combines the toad skin and the male silkworm moth oil to prepare the delayed oil agent, significantly improves male premature ejaculation and erectile dysfunction, and has the characteristics of direct action and simple operation. The preparation cost is low.

The present application relates to the technical field of medical equipment, and discloses a conformal wireless LIPUS erectile dysfunction treatment device based on a photoacoustic transducer, which comprises a pulsed light source emitter and a photoacoustic conversion composite material, and a use method of the treatment device, which comprises the following steps: uniformly applying the photoacoustic conversion composite material to a penis part of a patient, and allowing the photoacoustic conversion composite material to solidify to form a flexible conformal film layer; turning on the pulsed light source emitter, and irradiating the conformal film layer with far-infrared pulsed light emitted by the pulsed light source emitter; after the conformal film layer absorbs light energy of the far-infrared pulsed light, the light energy is converted into heat energy, then thermal expansion of the conformal film layer is caused, so that LIPUS is generated, and rehabilitation treatment is performed on the penis part of the patient. The present application provides a more portable, more comfortable and lower-cost LIPUS ED treatment device and method, and helps the clinical promotion and market application of LIPUS in the ED treatment field.

The invention provides a novel pharmaceutical composition comprising a phosphodiesterase type 5 (PDE5) inhibitor other than sildenafil and a dopamine agonist and method of use thereof for treating erectile dysfunction and / or male hypogonadism.

Microparticles that contain miRNA that controls the production of nitric oxide and are an agent for promoting the production of nitric oxide are new microparticles that enable controlling the expression of a protein and / or a gene related to erectile dysfunction; a preventive drug or a therapeutic drug for erectile dysfunction; a method for improving erectile dysfunction; it is preferable that the microparticles be exosomes; and it is preferable that the microparticles of the present disclosure contain miRNA targeting a gene concerning the expression of nitric oxide synthase as the miRNA that controls the production of nitric oxide, and be an agent for promoting the expression of nitric oxide synthase.

The invention relates to the field of traditional Chinese medicines, and discloses a traditional Chinese medicine composition for treating diabetes-related erectile dysfunction as well as a preparation method and application of the traditional Chinese medicine composition. The composition consists of a pharmaceutically acceptable carrier and an active ingredient, wherein the active ingredient consists of the following components in parts by weight: 5-15 parts of rhizoma acori graminei; 5-15 parts by weight of ligusticum wallichii; 5-15 parts by weight of radix curcumae; 5-15 parts by weight of polygala tenuifolia; 5-15 parts by weight of Chinese herbaceous peony; 5-15 parts by weight of Chinese angelica; 10-20 parts by weight of Radix Astragali; 5-15 parts by weight of semen cuscutae; 5-15 parts by weight of herba epimedii; 5-15 parts by weight of dens draconis; 5-15 parts by weight of tribulus terrestris; 5-15 parts by weight of radix bupleuri; and 5-15 parts by weight of rhizoma cyperi. The composition is prepared into various oral preparations such as granules, tablets, capsules, pills and the like through the processes of extraction, concentration, drying, granulation and the like. The application can significantly improve the erectile function index, erectile hardness and sexual life quality of DMED patients, improve the serum testosterone level of the patients and reduce blood sugar, and has the advantages of few adverse reactions and good safety.