88 results about "Sexual impotence" patented technology

The invention provides a polypeptide composition and application thereof in treating male erectile dysfunction. Specifically, the polypeptide composition contains the erectile peptide screened and identified by the invention, and the erectile peptide has good oxidation fatigue resistance, can effectively promote penile erection, improve testosterone level and effectively treat erectile dysfunction, and has wide application prospects.

The invention relates to haptoglobin or a nucleic acid encoding haptoglobin for use in treating or preventing of exaggerated erectile response and / or preventing permanent erectile dysfunction. In addition, the invention relates a pharmaceutical composition for use in treating or preventing exaggerated erectile response and / or preventing permanent erectile dysfunction, wherein the pharmaceutical composition comprises an adeno-associated viral (AAV) vector with a transgene encoding a haptoglobin gene. The exaggerated erectile response may be priapism, for example priapism associated with sickle cell disease (SCD).

There is provided a composition for topical application to the penis for the treatment of erectile dysfunction, the composition being free of glyceryl trinitrate (GTN), sildenafil and an acetylcholinesterase inhibitor, and comprising volatile and non-volatile solvents, the volatile solvents comprising a lower alcohol and water and the non-volatile solvents comprising a polyhydric alcohol and a glycol. Preferably, the composition does not contain any pharmaceutically active ingredients for the treatment of erectile dysfunction. Also provided is a method of determining the cooling ability of a test composition, such as the composition described above.

An implantable system for treatment of climacturia has an inflatable penile implant and an inflatable cuff that is implantable around at least a portion of a urethra. A pump is operatively coupled to the penile implant and to the cuff to inflate the penile implant in treating erectile dysfunction and to inflate the cuff in treating climacturia.

This invention belongs to the field of traditional Chinese medicine, specifically relating to a topical delay spray and its preparation method. The invention uses the dried epidermis of the Huaxi toad (with the toad venom removed), and extracts it efficiently through a combination of water and alcohol extraction. Male silkworm moth oil can nourish and strengthen the body, tonify the liver and kidneys, and combat fatigue; studies have shown that male silkworm moth oil can effectively treat kidney yang deficiency. This invention combines the synergistic effects of toad skin extract and male silkworm moth oil to prepare a delay spray that can significantly treat premature ejaculation and erectile dysfunction in men. This preparation has the advantages of direct action, sustained release, avoidance of drug contact, and simple operation. This invention further improves the rational utilization system of toad resources, provides a practical solution for the efficient development of toad medicinal resources, and significantly reduces production and clinical application costs.

A system for treating erectile dysfunction in a male person is disclosed. The system comprises a stimulation device configured to deliver, directly or indirectly: a first stimulation signal to a sympathetic nerve innervating a penile vein of the person; and a second stimulation signal to a parasympathetic nerve innervating a penile artery of the person. The system further comprises a control unit configured to control an operation of the stimulation device such that: the first stimulation signal stimulates an activity of the sympathetic nerve, thereby causing vasoconstriction of the penile vein; and the second stimulation signal stimulates an activity of the parasympathetic nerve, thereby causing vasodilation of the penile artery. The vasodilation of the penile artery increases a blood flow entering an erectile body of the penis and the vasoconstriction of the penile vein reduces a blood flow exiting the erectile body, thereby inducing engorgement of the erectile body.

Microparticles that contain miRNA that controls the production of nitric oxide and are an agent for promoting the production of nitric oxide are new microparticles that enable controlling the expression of a protein and / or a gene related to erectile dysfunction; a preventive drug or a therapeutic drug for erectile dysfunction; a method for improving erectile dysfunction; it is preferable that the microparticles be exosomes; and it is preferable that the microparticles of the present invention contain miRNA targeting a gene concerning the expression of nitric oxide synthase as the miRNA that controls the production of nitric oxide, and be an agent for promoting the expression of nitric oxide synthase.

The invention discloses a preparation for treating erectile dysfunction caused by diabetes as well as a preparation method and application of the preparation. The invention firstly finds that a palmitoylation modification site, namely a 282 site, exists beside a 260 site in an Fbp1 functional region, and the site can be modified by the palmitoylation site to cause Fbp1 function damage. Therefore, point mutation modified Fbp1 mRNA of a C282S site is found and synthesized for the first time, namely cysteine of a 282 site is converted into serine, so that the Fbp1 is not subjected to Zdhhc13 palmitoylation modification and further is not subjected to function damage, lipid nanoparticles capable of targeted delivery of the modified Fbp1 mRNA are synthesized, and the C282S-Fbp1 mRNA loaded by the nanoparticles is infiltrated into a mouse cavernous body, so that the number of the Fbp1 is recovered, and the activity of the C282S-Fbp1 is improved. Therefore, the lactic acid concentration of the DMED penis cavernosum is effectively reduced, and the erectile function of a DMED mouse is remarkably improved.

The present invention provides methods for the prevention or treatment of Erectile dysfunction (ED) by administering SLPIs to animals, such as male humans. These methods can be administer together with vitamin D and / or phosphodiesterase 5 inhibitors.

The invention provides application of lactobacillus reuteri to improvement of prostatitis and erectile dysfunction. The bacterial strain is lactobacillus reuteri NHNK-2001, the lactobacillus reuteri NHNK-2001 is preserved in the China Center for Type Culture Collection on April 25, 2024, and the preservation number of the lactobacillus reuteri NHNK-2001 is CCTCC (China Center for Type Culture Collection) NO: M 2024800. The NHNK-2001 has the functions of generating L-citrulline, repairing aged vascular endothelial cells, promoting vasodilation, repairing aged prostate cells and reducing prostatitis, and can be used for preparing products for improving prostatitis and erectile dysfunction.

The present invention relates to a crystalline form I represented by Formula 1, which may be characterized by XRD patterns, DSC profiles, and / or TGA profiles, a method for preparing the same, and a pharmaceutical composition comprising the same, useful for the treatment of prevention of obesity, diabetes, inflammation, or erectile dysfunction. (see formula 1) wherein R1 is C2-C5 alkyl.

The application of the autologous dendritic cell in preparation of the medicine for treating the nerve injury erectile dysfunction can well promote recovery of the erectile function, perform staged reinfusion, induce immune regulation, repair nerve and blood vessel functions and improve a sex hormone regulation pathway. And the autologous dendritic cells are derived from a user, and have the advantages of safety, effectiveness and convenience in use. The combined immune cell therapy is obviously superior to a single treatment path in efficacy, is also more suitable for chronic, non-structural, subclinical and other ED people which are difficult to intervene by traditional methods, and has stronger individual adaptation ability and long-term controllability at the same time. Compared with a traditional scheme, the cell therapy targeting is better, and the treatment effect is faster.

Disclosed in the present invention are a method and composition for improving reproductive health and related use thereof in preparing nutritional products, health-care products, foods, beverages, animal feeds, or drugs for improving reproductive health. The method and composition of the present invention can improve erectile dysfunction, increase testosterone level, ameliorate hypogonadism, and ameliorate decreased sexual desire.

To provide a new male climacteric disorder-ameliorating composition using a safe material free from side effects, and to provide a medicine, food and drink containing the composition.SOLUTION: The male climacteric disorder-improving composition contains a treated product of an Agaricus fruit body.SELECTED DRAWING: Figure 13

This invention discloses a traditional Chinese medicine composition for erectile dysfunction due to deficiency of both heart and spleen, and its application, belonging to the field of traditional Chinese medicine technology. The composition consists of a basic formula and modified formulas. The basic formula includes a spleen-tonifying and qi-boosting group, a heart-nourishing and blood-nourishing group, and a blood-activating and aphrodisiac group. The modified formulas are adjusted according to different concurrent symptoms. It can be prepared into various dosage forms such as decoctions and granules. This traditional Chinese medicine composition precisely addresses the core pathogenesis of erectile dysfunction due to deficiency of both heart and spleen—namely, "insufficient heart blood, deficiency of spleen qi, and malnourishment of the reproductive organs"—achieving spleen-tonifying and heart-nourishing, qi-boosting and blood-nourishing, and blood-activating and aphrodisiac effects, without causing stagnation or greasiness. Clinical trials have demonstrated definite efficacy, high overall effective rate, few adverse reactions, and low long-term recurrence rate. It can comprehensively improve patients' erectile function and accompanying symptoms, and is suitable for preparing drugs to treat erectile dysfunction due to deficiency of both heart and spleen.

The massage device using the fabric that is the article of the design is a massage device used in response to social needs, such as the need to treat erectile dysfunction through precise stimulation, alleviate insomnia and lower back pain, and prevent suicide through the euphoria caused by precise stimulation of the groin. This massage device is constructed by sewing together an outer fabric and an inner fabric with cushion holders, offset from each other to the left and right. The article has a pair of slits cut above and below the cushion holder in the outer fabric, and a pair of slits cut above and below the cushion holder in the inner fabric from the opposite direction to the outer fabric, allowing the cushion holder to be folded back between the pair of slits in the outer and inner fabrics. When the two cushion holders are folded back, an insertion opening is formed in the center. When used by a man, the penis is inserted into the insertion opening, the folded cushion is placed in close contact with the groin, and pressure is applied to the folded cushion, allowing for a groin massage.

This disclosure provides pharmaceutical compositions, such as compounds of formula Ib or formula IIb or their hydrates, spray-dried pharmaceutical compositions containing compounds of formula Ib or formula IIb or their hydrates, as well as methods for preparing and using the same, for the treatment and / or prevention of one or more of the following functional disorders or disorders: sexual dysfunction, erectile dysfunction, ejaculatory dysfunction, hypoactive sexual desire disorder, mental disorders, and neurological disorders. [Formula 1] TIFF2026529136000063.tif56109

There is provided a composition for topical application to the penis for the treatment of erectile dysfunction, the composition being free of glyceryl trinitrate (GTN), sildenafil and an acetylcholinesterase inhibitor, and comprising volatile and non-volatile solvents, the volatile solvents comprising a lower alcohol and water and the non-volatile solvents comprising a polyhydric alcohol and a glycol. Preferably, the composition does not contain any pharmaceutically active ingredients for the treatment of erectile dysfunction. Also provided is a method of determining the cooling ability of a test composition, such as the composition described above.

The invention provides a traditional Chinese medicine composition for treating type 2 diabetic erectile dysfunction and a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicine compositions. The composition is prepared from radix bupleuri, radix paeoniae alba, radix rehmanniae preparata, Chinese yam, fructus corni, cortex moutan, poria cocos, rhizoma alismatis, herba cistanche, centipede, flos carthami, cortex eucommiae, radix angelicae sinensis and liquorice root. Clinical research proves that the total treatment effective rate of the traditional Chinese medicine composition reaches 78.13% which is obviously superior to 28.13% of a control group, the IIEF-5 score can be obviously improved, the traditional Chinese medicine symptoms can be improved, the effect on the aspects of improving sexual confidence and sexual nature indexes, reducing time worry and other psychological indexes is outstanding, and meanwhile the adverse drug reaction occurrence rate is not obviously different from that of the control group. The traditional Chinese medicine composition has the advantages of definite curative effect, integral regulation and simultaneous treatment of mind and body, and can be popularized and applied on a large scale.

To provide a new male climacteric disorder-ameliorating composition using a safe material free from side effects, and to provide a medicine, food and drink containing the composition.SOLUTION: The male climacteric disorder-improving composition contains a treated product of an Agaricus fruit body.SELECTED DRAWING: Figure 13

Provided is a method for treating disorders or conditions related to erectile dysfunction. The method includes administering to a subject in need thereof a therapeutically effective amount of mesenchymal stem cells or secretome thereof, wherein the mesenchymal stem cells or secretome are derived from human amniotic fluid.

The invention further relates to compounds, pharmaceutical compositions and methods for treating a subject for sexual function, such as sexual disorder or sexual dysfunction (SD), for inducing subject weight loss, for effectuating weight maintenance by a subject, whether or not the weight maintenance is used alone or in combination with a subject's weight loss, and / or for improving a subject's subjective state of well-being, self-esteem and / or self-confidence. Examples of SD contemplated by the present invention include but are not limited to female sexual disorder (FSD), female sexual arousal disorder (FSAD), female sexual interest / arousal disorder (FSIAD), female hypoactive sexual desire disorder (HSDD), female orgasmic disorder (FOD), female sexual pain disorder (FSPD), sexual interest arousal disorder (SIAD), male sexual disorder (MSD), male hypoactive sexual desire disorder (MSHDD), erectile dysfunction (ED), Pyronine's disease (PD), male premature ejaculation (MPE), male delayed ejaculation (MDE), male decreased libido (MDL), male dry orgasm (MDO).

The invention relates to the technical field of health care appliances, in particular to an electric penis erection assisting rod which comprises a power bin, a negative pressure generation bin, a connecting assembly and a negative pressure stimulation assembly, a negative pressure pump of the penis erection assisting rod is communicated with an air exhaust hole in the negative pressure stimulation assembly through an air pipe, and then the negative pressure pump and a containing cavity form a complete negative pressure system. After a user puts the penis into the containing cavity, negative pressure acts on the surface of the penis, and blood filling in the cavernous body of the penis can be effectively promoted. The attaching groove is formed in the end, away from the connecting assembly, of the negative pressure stimulation assembly in a surrounding mode, the arc-shaped structure of the attaching groove can be tightly attached to the root of the penis and the skin around the penis, it is ensured that the penis obtains all-around uniform stress under the negative pressure effect, and discomfort or injury possibly caused by uneven local pressure is avoided; meanwhile, the stability and continuity of the negative pressure effect are enhanced, the effect of promoting penis hyperemia expansion is further improved, and the effect of improving erectile dysfunction is remarkable.

The erectile dysfunction erection-assisting and sensitivity-reducing shield device comprises a shield device supporting piece and a simulation penis head connected with the front end of the shield device supporting piece. The shield device supporting piece is provided with a semi-open arc-shaped groove which partially wraps the cavernous body of the penis of a patient. A penis head cavity is formed in the joint of the simulated penis head and the shield device supporting piece, and the penis head located in the penis head cavity can be isolated from the female vagina. On the premise that normal experience of wives is guaranteed, erectile dysfunction patients can obtain proper sexual stimulation, so that the patients are helped to erect, and the problems of premature ejaculation and the like caused by excessive sexual stimulation can be well prevented. Moreover, the patient can adjust the degree of obtaining sexual stimulation and exercise the sensitivity of the penis through products of different models, and obtains better experience, so that the patient recovers the interest and confidence in sexual life. Through the physiological and psychological effects, the illness state of a patient is improved, the improvement of the good sensitivity of couples is facilitated, and the society is more harmonious.

A marker for characterizing an EPC subpopulation, an EPC subpopulation, and a use thereof. Indicators for distinguishing EPC subpopulations comprise CD144, vWF, CD133, or phagocytic capacity. On the basis of these indicators, identification, sorting, separation, or enrichment of EPC subpopulations can be achieved. Also provided are a use of late EPC in the preparation of a drug for treating stroke, erectile dysfunction, and ischemic diseases, and a method for treating stroke, erectile dysfunction, and ischemic diseases.

The present invention relates to haptoglobin or a nucleic acid encoding haptoglobin for use in the treatment or prevention of an excessive erectile response and / or the prevention of permanent erectile dysfunction. Furthermore, the present invention relates to a pharmaceutical composition for use in the treatment or prevention of an excessive erectile response and / or the prevention of permanent erectile dysfunction, the pharmaceutical composition comprising an adeno-associated virus (AAV) vector carrying a transgene encoding a haptoglobin gene. The excessive erectile response may be, for example, priapism associated with sickle cell disease (SCD).

This invention relates to a restraint-free wearable intelligent sensing device and method for patients with erectile dysfunction (ED), belonging to the field of medical monitoring equipment and technology. The device includes an underwear-like main structure, a data acquisition unit, a micro-control module, a power supply module, and an electrical stimulation module. The underwear-like main structure has a data acquisition and monitoring area composed of multiple annular fiber sensing units arranged in a columnar elephant trunk structure. Each annular fiber sensing unit has an independent pressure-sensitive fiber sensing module. The data acquisition unit collects the wearer's pressure and temperature data in real time. The micro-control module is connected to the data acquisition unit to process and transmit the data collected. The method employs a multi-sensor signal processing stage algorithm and a cloud-based monitoring and closed-loop control stage algorithm. Based on the acquired loop-level monitoring data, it provides real-time feedback and prompts for adjustments, improving treatment convenience and personalization, and providing a more comprehensive, precise, and restraint-free solution for ED monitoring.

[Problem] To propose a novel composition useful for ameliorating male menopausal disorder and / or erectile dysfunction. [Solution] An agent for ameliorating erectile dysfunction and / or an agent for ameliorating male menopausal disorder comprise a human stem cell supernatant liquid as an active ingredient. The agent for ameliorating erectile dysfunction and / or the agent for ameliorating male menopausal disorder are a cream to be used by being applied to a human body and comprise a human stem cell supernatant liquid as an active ingredient.