124 results about "Sexual impotence" patented technology

The invention provides a polypeptide composition and application thereof in treating male erectile dysfunction. Specifically, the polypeptide composition contains the erectile peptide screened and identified by the invention, and the erectile peptide has good oxidation fatigue resistance, can effectively promote penile erection, improve testosterone level and effectively treat erectile dysfunction, and has wide application prospects.

Sublingual compositions for the treatment of erectile dysfunction (ED) comprise unique combinations of phosphodiesterase-type 5 (PDE5) inhibitors and D1 / D2 dopamine receptor agonists. In preferred embodiments, a combination of four drug actives exhibits a full range of effectiveness for ED in which there is a short and long acting PDE5 inhibitor in combination with both a dopamine agonist and a CNS hormone to provide both a physiological response and a psychological / CNS action. A treatment for ED comprises administration of sublingual compositions in the physical form of sublingual tablets.

The invention provides a functional peptide with a yang tonifying effect, a seal penis peptide and a preparation method and application of the functional peptide and the seal penis peptide. The functional peptide comprises a peptide fragment pER and can promote testicular interstitial cells to secrete testosterone. Testosterone is steroid hormone and can be secreted by testicular interstitial cells through enzymatic reaction. The low testosterone level in serum can cause male testicular atrophy and low sperm survival rate, so that the male reproductive function is influenced, and the phenomena of poor sexual desire, premature ejaculation, erectile dysfunction and the like can also be caused. In addition, the testosterone also has the effects of maintaining muscle strength and quality, maintaining bone density and strength, refreshing, improving physical ability and the like. Therefore, the functional peptide provided by the invention has the effect of promoting the secretion of testosterone, which means that the functional peptide not only can effectively improve the male sexual function, but also can alleviate the damage of male sexual dysfunction to the body and spirit.

The invention provides a novel pharmaceutical composition comprising sildenafil and cabergoline and method of use thereof for treating erectile dysfunction and / or male hypogonadism.

The invention relates to haptoglobin or a nucleic acid encoding haptoglobin for use in treating or preventing of exaggerated erectile response and / or preventing permanent erectile dysfunction. In addition, the invention relates a pharmaceutical composition for use in treating or preventing exaggerated erectile response and / or preventing permanent erectile dysfunction, wherein the pharmaceutical composition comprises an adeno-associated viral (AAV) vector with a transgene encoding a haptoglobin gene. The exaggerated erectile response may be priapism, for example priapism associated with sickle cell disease (SCD).

There is provided a composition for topical application to the penis for the treatment of erectile dysfunction, the composition being free of glyceryl trinitrate (GTN), sildenafil and an acetylcholinesterase inhibitor, and comprising volatile and non-volatile solvents, the volatile solvents comprising a lower alcohol and water and the non-volatile solvents comprising a polyhydric alcohol and a glycol. Preferably, the composition does not contain any pharmaceutically active ingredients for the treatment of erectile dysfunction. Also provided is a method of determining the cooling ability of a test composition, such as the composition described above.

An implantable system for treatment of climacturia has an inflatable penile implant and an inflatable cuff that is implantable around at least a portion of a urethra. A pump is operatively coupled to the penile implant and to the cuff to inflate the penile implant in treating erectile dysfunction and to inflate the cuff in treating climacturia.

This invention belongs to the field of traditional Chinese medicine, specifically relating to a topical delay spray and its preparation method. The invention uses the dried epidermis of the Huaxi toad (with the toad venom removed), and extracts it efficiently through a combination of water and alcohol extraction. Male silkworm moth oil can nourish and strengthen the body, tonify the liver and kidneys, and combat fatigue; studies have shown that male silkworm moth oil can effectively treat kidney yang deficiency. This invention combines the synergistic effects of toad skin extract and male silkworm moth oil to prepare a delay spray that can significantly treat premature ejaculation and erectile dysfunction in men. This preparation has the advantages of direct action, sustained release, avoidance of drug contact, and simple operation. This invention further improves the rational utilization system of toad resources, provides a practical solution for the efficient development of toad medicinal resources, and significantly reduces production and clinical application costs.

A system for treating erectile dysfunction in a male person is disclosed. The system comprises a stimulation device configured to deliver, directly or indirectly: a first stimulation signal to a sympathetic nerve innervating a penile vein of the person; and a second stimulation signal to a parasympathetic nerve innervating a penile artery of the person. The system further comprises a control unit configured to control an operation of the stimulation device such that: the first stimulation signal stimulates an activity of the sympathetic nerve, thereby causing vasoconstriction of the penile vein; and the second stimulation signal stimulates an activity of the parasympathetic nerve, thereby causing vasodilation of the penile artery. The vasodilation of the penile artery increases a blood flow entering an erectile body of the penis and the vasoconstriction of the penile vein reduces a blood flow exiting the erectile body, thereby inducing engorgement of the erectile body.

A method for preventing, ameliorating or treating one or more disease or disorders selected from the group consisting of a skin disease, skin aging or steroid-induced skin atrophy, erectile dysfunction, and hair loss, comprises transdermally administering a compound of formula I or a pharmaceutically acceptable salt thereof to a subject in need thereof.WhereinR1 is C1-C3alkyl;R2 is H, CHO or CH═N—OH;R3 is C1-C4alkyl;R4 is C1-C6alkyl;R5 is SO2NR6R7;wherein R6 and R7 are together with the nitrogen atom to which they are attached form a heterocyclic ring, wherein said heterocyclic ring is selected from piperidine and piperazine, wherein said heterocyclic ring is substituted with at least one R8, and wherein said R8 is independently selected from C1-C6alkyl optionally substituted with OH, ONO2, wherein at least one of said at least one R8 comprises at least one ONO2 moiety.

Microparticles that contain miRNA that controls the production of nitric oxide and are an agent for promoting the production of nitric oxide are new microparticles that enable controlling the expression of a protein and / or a gene related to erectile dysfunction; a preventive drug or a therapeutic drug for erectile dysfunction; a method for improving erectile dysfunction; it is preferable that the microparticles be exosomes; and it is preferable that the microparticles of the present invention contain miRNA targeting a gene concerning the expression of nitric oxide synthase as the miRNA that controls the production of nitric oxide, and be an agent for promoting the expression of nitric oxide synthase.

The invention discloses a preparation for treating erectile dysfunction caused by diabetes as well as a preparation method and application of the preparation. The invention firstly finds that a palmitoylation modification site, namely a 282 site, exists beside a 260 site in an Fbp1 functional region, and the site can be modified by the palmitoylation site to cause Fbp1 function damage. Therefore, point mutation modified Fbp1 mRNA of a C282S site is found and synthesized for the first time, namely cysteine of a 282 site is converted into serine, so that the Fbp1 is not subjected to Zdhhc13 palmitoylation modification and further is not subjected to function damage, lipid nanoparticles capable of targeted delivery of the modified Fbp1 mRNA are synthesized, and the C282S-Fbp1 mRNA loaded by the nanoparticles is infiltrated into a mouse cavernous body, so that the number of the Fbp1 is recovered, and the activity of the C282S-Fbp1 is improved. Therefore, the lactic acid concentration of the DMED penis cavernosum is effectively reduced, and the erectile function of a DMED mouse is remarkably improved.

The present invention provides methods for the prevention or treatment of Erectile dysfunction (ED) by administering SLPIs to animals, such as male humans. These methods can be administer together with vitamin D and / or phosphodiesterase 5 inhibitors.

The invention provides application of lactobacillus reuteri to improvement of prostatitis and erectile dysfunction. The bacterial strain is lactobacillus reuteri NHNK-2001, the lactobacillus reuteri NHNK-2001 is preserved in the China Center for Type Culture Collection on April 25, 2024, and the preservation number of the lactobacillus reuteri NHNK-2001 is CCTCC (China Center for Type Culture Collection) NO: M 2024800. The NHNK-2001 has the functions of generating L-citrulline, repairing aged vascular endothelial cells, promoting vasodilation, repairing aged prostate cells and reducing prostatitis, and can be used for preparing products for improving prostatitis and erectile dysfunction.

The present invention relates to a crystalline form I represented by Formula 1, which may be characterized by XRD patterns, DSC profiles, and / or TGA profiles, a method for preparing the same, and a pharmaceutical composition comprising the same, useful for the treatment of prevention of obesity, diabetes, inflammation, or erectile dysfunction. (see formula 1) wherein R1 is C2-C5 alkyl.

The application of the autologous dendritic cell in preparation of the medicine for treating the nerve injury erectile dysfunction can well promote recovery of the erectile function, perform staged reinfusion, induce immune regulation, repair nerve and blood vessel functions and improve a sex hormone regulation pathway. And the autologous dendritic cells are derived from a user, and have the advantages of safety, effectiveness and convenience in use. The combined immune cell therapy is obviously superior to a single treatment path in efficacy, is also more suitable for chronic, non-structural, subclinical and other ED people which are difficult to intervene by traditional methods, and has stronger individual adaptation ability and long-term controllability at the same time. Compared with a traditional scheme, the cell therapy targeting is better, and the treatment effect is faster.

The utility model relates to medicine, in particular to sexology, and to a prosthesis for treating erectile dysfunction. The technical result of the utility model claimed for protection is to increase the comfort of wearing and the stability of the distal part at the level of the recess during penetration, as well as the rigidity of the middle part during sexual intercourse. The penis prosthesis is made of an elastic bioinert material, comprising a distal part, a recessed middle part and a proximal part. The distal part has a cylindrical shape, a semi-elliptical end, and has one or more pairs of recesses forming a secondary semi-ellipse; and the proximal part is configured as a truncated cone narrowed in the proximal direction and ends with a semi-ellipse, wherein the proximal part has a transverse annular recess. The narrowing in the lower part of the recessed middle part is greater than the narrowing in the upper part or the side part of the recessed middle part, and the cross-sectional area of ​​the middle part is smaller than the cross-sectional area of ​​the distal or proximal part.

The invention belongs to the technical field of traditional Chinese medicine ointment preparation, and discloses a traditional Chinese medicine ointment patch for treating bone symptoms and a preparation process. The traditional Chinese medicine plaster for treating bone symptoms is prepared from the following raw materials: rheum officinale, ground beeltle, radix achyranthis bidentatae, radix clematidis, pangolin, monkey bone, schizophragma integrifolium, myrrh, rhizoma cibotii, ligusticum wallichii, pawpaw, uncaria, sargentgloryvine stem, asarum, cinnamon, semen strychni, poria cocos, radix paeoniae alba, radix angelicae, dragon's blood, cottonrose hibiscus leaves, frankincense, vegetable oil and red lead. The traditional Chinese medicine plaster for treating bone symptoms can be used for various muscle strain lesions, can be used for various traumatic injuries, fractures, tendon and vessel contracture and the like, and can also be used for symptoms such as arthritis, scapulohumeral periarthritis, cervical spondylosis and hyperostosis; the traditional Chinese medicine has the effects of promoting blood circulation to remove blood stasis, relieving swelling and pain, relaxing tendons and regulating qi, dispelling cold and wind and promoting reunion of fractured tendons and bones, takes effect quickly and does not cause adverse reaction easily.

The invention relates to a traditional Chinese medicine composition for treating damp-heat downward flow type erectile dysfunction. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 3-9 parts of radix gentianae, 1-3 parts of centipede, 5-10 parts of earthworm, 3-9 parts of fructus cnidii, 3-9 parts of radix et rhizoma rhei, 3-9 parts of radix angelicae sinensis, 3-9 parts of radix rehmanniae recen, 3-9 parts of bupleurum chinense, 6-15 parts of semen plantaginis, 3-9 parts of caulis clematidis armandii, 3-9 parts of rhizoma alismatis, 15-30 parts of poria cocos and 10-30 parts of herba epimedii. According to the pathogenesis characteristics of damp-heat downward flow type, especially erectile dysfunction caused by stasis obstruction caused by damp-heat accumulation in bladder and prostate, the radix gentianae liver purging decoction is adopted as a basic formula, and the traditional Chinese medicine is prepared through addition and subtraction. All the medicines are compatible, the effects of clearing damp-heat in lower jiao and soothing liver and vibrating yang are further enhanced compared with a basic formula, and the whole formula has the effects of clearing heat and promoting diuresis, promoting blood circulation to remove meridian obstruction and soothing liver and eliminating wilt together.

Disclosed in the present invention are a method and composition for improving reproductive health and related use thereof in preparing nutritional products, health-care products, foods, beverages, animal feeds, or drugs for improving reproductive health. The method and composition of the present invention can improve erectile dysfunction, increase testosterone level, ameliorate hypogonadism, and ameliorate decreased sexual desire.

To provide a new male climacteric disorder-ameliorating composition using a safe material free from side effects, and to provide a medicine, food and drink containing the composition.SOLUTION: The male climacteric disorder-improving composition contains a treated product of an Agaricus fruit body.SELECTED DRAWING: Figure 13

This invention discloses a traditional Chinese medicine composition for erectile dysfunction due to deficiency of both heart and spleen, and its application, belonging to the field of traditional Chinese medicine technology. The composition consists of a basic formula and modified formulas. The basic formula includes a spleen-tonifying and qi-boosting group, a heart-nourishing and blood-nourishing group, and a blood-activating and aphrodisiac group. The modified formulas are adjusted according to different concurrent symptoms. It can be prepared into various dosage forms such as decoctions and granules. This traditional Chinese medicine composition precisely addresses the core pathogenesis of erectile dysfunction due to deficiency of both heart and spleen—namely, "insufficient heart blood, deficiency of spleen qi, and malnourishment of the reproductive organs"—achieving spleen-tonifying and heart-nourishing, qi-boosting and blood-nourishing, and blood-activating and aphrodisiac effects, without causing stagnation or greasiness. Clinical trials have demonstrated definite efficacy, high overall effective rate, few adverse reactions, and low long-term recurrence rate. It can comprehensively improve patients' erectile function and accompanying symptoms, and is suitable for preparing drugs to treat erectile dysfunction due to deficiency of both heart and spleen.

The invention discloses treatment equipment for reducing positive incisal margin after radical prostate resection, which comprises an injection device for injecting a PSMA probe into a body, a PET / CT (positron emission tomography / computed tomography) imaging device, a near-infrared fluorescence imaging device and a surgical robot, and is characterized in that the near-infrared fluorescence imaging device displays fluorescence levels of tumor tissues and normal tissues of the prostate of a patient injected with the probe; and carrying out fluorescence imaging on the prostate tumor tissue according to the fluorescence intensity of the probe in the urine. The treatment equipment disclosed by the invention is used for carrying out fluorescence imaging and accurate positioning on tumor tissues in an excision operation, the surgical robot is used for accurately excising the tumor tissues under fluorescence navigation, and the postoperative excision edge positive rate is obviously reduced; after the treatment equipment is adopted to carry out radical prostate resection, the biochemical recurrence risk of a patient is obviously reduced, and the prognosis is good; in addition, complications such as erectile dysfunction, urinary incontinence and urethrostenosis caused by injury of nerve and blood vessel bundles in an operation can be avoided, and the influence on the postoperative life quality of a patient is remarkably reduced.

The massage device using the fabric that is the article of the design is a massage device used in response to social needs, such as the need to treat erectile dysfunction through precise stimulation, alleviate insomnia and lower back pain, and prevent suicide through the euphoria caused by precise stimulation of the groin. This massage device is constructed by sewing together an outer fabric and an inner fabric with cushion holders, offset from each other to the left and right. The article has a pair of slits cut above and below the cushion holder in the outer fabric, and a pair of slits cut above and below the cushion holder in the inner fabric from the opposite direction to the outer fabric, allowing the cushion holder to be folded back between the pair of slits in the outer and inner fabrics. When the two cushion holders are folded back, an insertion opening is formed in the center. When used by a man, the penis is inserted into the insertion opening, the folded cushion is placed in close contact with the groin, and pressure is applied to the folded cushion, allowing for a groin massage.

This disclosure provides pharmaceutical compositions, such as compounds of formula Ib or formula IIb or their hydrates, spray-dried pharmaceutical compositions containing compounds of formula Ib or formula IIb or their hydrates, as well as methods for preparing and using the same, for the treatment and / or prevention of one or more of the following functional disorders or disorders: sexual dysfunction, erectile dysfunction, ejaculatory dysfunction, hypoactive sexual desire disorder, mental disorders, and neurological disorders. [Formula 1] TIFF2026529136000063.tif56109

There is provided a composition for topical application to the penis for the treatment of erectile dysfunction, the composition being free of glyceryl trinitrate (GTN), sildenafil and an acetylcholinesterase inhibitor, and comprising volatile and non-volatile solvents, the volatile solvents comprising a lower alcohol and water and the non-volatile solvents comprising a polyhydric alcohol and a glycol. Preferably, the composition does not contain any pharmaceutically active ingredients for the treatment of erectile dysfunction. Also provided is a method of determining the cooling ability of a test composition, such as the composition described above.

The invention provides a traditional Chinese medicine composition for treating type 2 diabetic erectile dysfunction and a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicine compositions. The composition is prepared from radix bupleuri, radix paeoniae alba, radix rehmanniae preparata, Chinese yam, fructus corni, cortex moutan, poria cocos, rhizoma alismatis, herba cistanche, centipede, flos carthami, cortex eucommiae, radix angelicae sinensis and liquorice root. Clinical research proves that the total treatment effective rate of the traditional Chinese medicine composition reaches 78.13% which is obviously superior to 28.13% of a control group, the IIEF-5 score can be obviously improved, the traditional Chinese medicine symptoms can be improved, the effect on the aspects of improving sexual confidence and sexual nature indexes, reducing time worry and other psychological indexes is outstanding, and meanwhile the adverse drug reaction occurrence rate is not obviously different from that of the control group. The traditional Chinese medicine composition has the advantages of definite curative effect, integral regulation and simultaneous treatment of mind and body, and can be popularized and applied on a large scale.

To provide a new male climacteric disorder-ameliorating composition using a safe material free from side effects, and to provide a medicine, food and drink containing the composition.SOLUTION: The male climacteric disorder-improving composition contains a treated product of an Agaricus fruit body.SELECTED DRAWING: Figure 13

Provided is a method for treating disorders or conditions related to erectile dysfunction. The method includes administering to a subject in need thereof a therapeutically effective amount of mesenchymal stem cells or secretome thereof, wherein the mesenchymal stem cells or secretome are derived from human amniotic fluid.