119 results about "Sexual functioning" patented technology

The invention provides an intelligent physical therapy cushion which comprises a supporting framework, a split type cushion body, a multifunctional physical therapy module and a main control system, the split type cushion body is detachably installed on the supporting framework, and the multifunctional physical therapy module and the main control system are further installed in the split type cushion body. A skin contact layer and an elastic filling layer are sequentially arranged on the split type cushion body from outside to inside, the skin contact layer is made of a flexible conductive material, and the multifunctional physiotherapy module is composed of a pulse physiotherapy unit, a hot compress physiotherapy unit and a vibration physiotherapy unit. The pulse physical therapy unit, the hot compress physical therapy unit and the vibration physical therapy unit are arranged in the cushion body, low-frequency pulse electrical stimulation, hot compress and vibration physical therapy can be conducted on specific acupuncture points, blood circulation is promoted, fatigue is relieved, the sexual function is improved, pain is relieved, tissue repair is promoted, muscles are relaxed, and pressure is relieved; the sitting posture, the lying posture and other use postures can be adjusted, and the use comfort is improved.

The invention discloses a composition based on an engineered stem cell exosome and application of the composition in treating male sexual dysfunction. The composition comprises a mesenchymal stem cell exosome modified by genetic engineering, and the surface of the mesenchymal stem cell exosome displays a bifunctional fusion polypeptide targeting TbetaR II and LOXL2. According to the fusion polypeptide, TbetaR-PEP and LOXL2-PEP are integrated through a flexible linker, and an HIV-TAT penetrating peptide and a self-assembly motif are introduced, so that nanoparticles are formed, and the half-life period is prolonged. In-vitro experiments show that the inhibition efficiency of the fusion polypeptide on TbetaRII and LOXL2 is obviously superior to that of a single peptide, and the fusion polypeptide can synergistically reverse fibrosis and promote angiogenesis. Animal experiments prove that the exosome loaded with the fusion polypeptide can significantly improve the erectile function of diabetic ED rats. According to the invention, a radical treatment scheme is provided for male sexual dysfunction through double-target cooperation, long-acting delivery and a multi-effect repair mechanism.

The invention provides a functional peptide with a yang tonifying effect, a seal penis peptide and a preparation method and application of the functional peptide and the seal penis peptide. The functional peptide comprises a peptide fragment pER and can promote testicular interstitial cells to secrete testosterone. Testosterone is steroid hormone and can be secreted by testicular interstitial cells through enzymatic reaction. The low testosterone level in serum can cause male testicular atrophy and low sperm survival rate, so that the male reproductive function is influenced, and the phenomena of poor sexual desire, premature ejaculation, erectile dysfunction and the like can also be caused. In addition, the testosterone also has the effects of maintaining muscle strength and quality, maintaining bone density and strength, refreshing, improving physical ability and the like. Therefore, the functional peptide provided by the invention has the effect of promoting the secretion of testosterone, which means that the functional peptide not only can effectively improve the male sexual function, but also can alleviate the damage of male sexual dysfunction to the body and spirit.

The present application relates to the technical field of stem cell medicine, in particular to a mesenchymal stem cell composition for treating prostate diseases and a preparation method and application thereof. The mesenchymal stem cell composition for treating prostate diseases comprises mesenchymal stem cells treated by low oxygen and an anti-inflammatory peptide WYPWMKKHHRRRRRRRRR. The prostate diseases are selected from prostatitis, prostate calcification, sexual function improvement, frequent urination and urgency, etc. The mesenchymal stem cell composition can significantly improve the symptoms of prostate diseases, and the curative effect is remarkable.

The present invention relates to an oral extract composition comprising Shatavari (Asparagus racemosus Willd.) and Fenugreek (Trigonella foenum-graecum L.) extract composition, and its process of preparation. Also relates to the oral extract composition formulation comprising with synergistic combinations of the Shatavari (Asparagus racemosus Willd.) and Fenugreek (Trigonella foenum-graecum L.) in suitable doses and at least one nutraceutically and / or pharmaceutically accepted excipient for, improvement, and maintenance of women health more preferably in improving of hot flashes, night sweats, poor sleep, anxiety, sexual dysfunction, mood changes, Genitourinary symptoms in overall improving the quality of life, serum estradiol, progesterone, follicle stimulating hormone (FSH), and cortisol during the period of menopause (perimenopause and menopause). The oral extract composition formulation comprising with synergistic combinations of the Shatavari (Asparagus racemosus Willd.) and Fenugreek (Trigonella foenum-graecum L.) in suitable doses and at least one nutraceutically and / or pharmaceutically accepted excipient is used for improving Brain-derived neurotrophic factor (BDNF) levels in women during the period of menopause. The present invention, further related to the extraction process of Shatavari (Asparagus racemosus Willd.) and Fenugreek (Trigonella foenum-graecum L.), also provides the process for the preparation of formulation composition. This invention further relates to the extraction process from Shatavari (Asparagus racemosus Willd.) and Fenugreek (Trigonella foenum-graecum L.) either as individual herbs or co-extraction of the two herbs or mixing the extracts at various stages of the individual extracts.

The invention discloses a medicinal and edible composition formula capable of resisting aging and improving sexual function. The invention belongs to the technical field of anti-aging. The medicinal and edible composition formula disclosed by the invention has remarkable anti-aging and sexual function improving effects; cell aging can be effectively delayed, the metabolic capability of a body is enhanced, and an endocrine system is regulated, so that a young state and a good sexual function are kept; according to the formula, natural medicinal and edible food materials are adopted, so that the safety is extremely high, and the side effect is extremely small; the formula is beneficial to improving the psychological state and life quality, enhancing the immunity of the body, improving the resistance of the body and reducing the occurrence of diseases.

The present invention relates to the technical field of functional gel preparation, and in particular to a method for preparing a functional gel. The functional gel preparation steps provided by the present invention are as follows: 50 parts of 50°C water, 11 parts of carbomer, and 5 parts of xanthan gum are mixed and stirred at 150 rpm for 10 minutes to obtain material 1; material 1 is mixed with 6 parts of isopropyl palmitate and stirred at 200 rpm for 20 minutes to obtain material 2; material 2 is cooled to 23°C, mixed with 25 parts of 80% ethanol by volume, 13 parts of 50% n-butanol by volume, 14 parts of glycerol, and 3 parts of propyl paraben, and stirred at 200 rpm for 20 minutes; and the pH is adjusted to 5.4 using sodium carbonate as a pH adjuster to obtain a functional gel. The functional gel prepared by the present invention does not contain any pharmaceutical ingredients, is safe and non-irritating during use, and has excellent therapeutic effects on male sexual dysfunction, with the therapeutic effects comparable to those of existing drugs.

The present invention belongs to the fields of medicine, health care and food, and specifically relates to use of a composition of alcohol and a cooling agent in regulating sexual functions, protecting cardiovascular and cerebrovascular systems, promoting regeneration of liver cells, preventing and / or treating tumors, and improving immunity and sleep quality. The technical problem to be resolved by the present invention is to provide the use of a composition of alcohol and a cooling agent in regulating sexual functions, protecting cardiovascular and cerebrovascular systems, promoting regeneration of liver cells, preventing and / or treating tumors, and improving immunity and sleep quality. The composition of the present invention includes the alcohol and the cooling agent. Further, the composition includes an organic acid. The alcohol in the composition is 1%vol-99%vol, and the cooling agent therein is 0.05ppm-500ppm. The composition provided according to the present invention can play the role of regulating sexual functions, protecting cardiovascular and cerebrovascular systems, promoting regeneration of liver cells, preventing and / or treating tumors, and improving immunity and sleep quality in a short period.

The invention relates to steroids and / or functional analogues thereof for use in a method of treating an individual suffering from sexual dysfunction. Said steroids may be combined with an effective dosage of oxytocin and / or a functional analogue thereof.

The present disclosure relates to the treatment of female sexual dysfunction with chromene-2-one compounds.

The invention belongs to the technical field of traditional Chinese medicine compositions, and particularly relates to a traditional Chinese medicine composition for invigorating kidney, strengthening yang and resisting fatigue and a preparation method and application thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 20 to 30 parts of cornu cervi pantotrichum, 20 to 30 parts of penis cervi, 15 to 25 parts of radix rehmanniae recen, 10 to 20 parts of rhizoma dioscoreae, 5 to 15 parts of cortex moutan, 15 to 25 parts of poria cocos, 10 to 20 parts of rhizoma alismatis and 5 to 15 parts of tetrapanax papyriferus. The traditional Chinese medicine composition prepared by the invention aims at soreness and weakness of waist and knees, intolerance of cold and cold limbs and sexual dysfunction caused by insufficiency of kidney-yang, treats both symptoms and root causes through the compatibility of warming yang and nourishing yin, and can enhance immunity, improve chronic fatigue and relieve physical exhaustion at the same time.

The invention discloses a prostate tumor steam ablation system and a using method thereof.The prostate tumor steam ablation system comprises operation equipment and a control host, and the operation equipment comprises an outer sleeve, a handle, a steam generator, a steam delivery needle, an angle sensor for obtaining the rotation angle of the steam delivery needle and delivery needle driving equipment; the end, away from the steam delivery needle, of the steam generator is connected with a sterile water inlet pipe. The end, away from the handle, of the outer sleeve is provided with a camera and integrated with a magnetic positioning sensor. The control host comprises a data processing control unit; the data processing control unit is used for processing prostate examination data of a patient before an operation to obtain a three-dimensional model of the prostate, determining a prostate tumor processing scheme according to user setting, and processing related data collected by the camera, the magnetic positioning sensor and the angle sensor to obtain a three-dimensional model of the outer sleeve and the steam delivery needle in the prostate. The steam ablation equipment is applied to the field of prostate tumor treatment for the first time, the treatment recovery time is short, and the male sexual function is reserved.

This invention provides a disposable underwear with a traditional Chinese medicine interlayer for regulating male sexual function, belonging to the field of disposable underwear technology. It includes: an underwear body, pant legs, a waistband, and a crotch protector. The crotch protector is located in the crotch area of ​​the underwear body, forming an interlayer structure filled with a traditional Chinese medicine composition for regulating male sexual function. The inner surface of the crotch protector has a breathable fabric with multiple air vents. The breathable fabric is adhered to the traditional Chinese medicine composition layer. The skin-friendly non-woven breathable fabric on the inner side of the crotch protector is in direct contact with human skin. The evenly distributed air vents allow the effective components of the traditional Chinese medicine composition to slowly penetrate and release, directly acting on acupoints and skin in the male groin area to achieve a regulating effect. The array of breathable holes on the outer side of the crotch protector connects to the interior of the interlayer, forming an internal and external breathable channel, accelerating the volatilization and penetration of the traditional Chinese medicine components, and promptly wicking away sweat from the groin area, avoiding stuffiness and dampness, and ensuring dryness while wearing the underwear.

A male sexual function therapeutic instrument belongs to the technical field of male sexual function disease health care instruments. The male sexual function therapeutic instrument solves the problems that an existing male sexual function therapeutic instrument is complex in structure and operation and simple in function. A face shell and a bottom shell are connected in a matched mode to form a cavity, a water tank, an air pump, a water pump and a main control board are arranged in the cavity, the water pump is connected with the water tank in a matched mode, the main control board, the air pump and the water pump are connected with a treatment head socket in a matched mode, and an interface of the treatment head socket penetrates through the face shell and the bottom shell to be arranged outside the face shell and the bottom shell. One end of the treatment head assembly is cooperatively connected with the treatment head socket, the treatment head assembly is connected with a treatment cylinder, the water tank is connected with the treatment head assembly through a water pump, and the main control board is provided with an electromagnetic valve and a DC socket. The male sexual function therapeutic apparatus is simple in structure and has more practical functions.

The invention discloses a construction method, system, equipment, product and medium for an ablation protection area, and the method comprises the steps: obtaining a cross-sectional image set of a prostate target area, the cross-sectional image set comprising a first cross-sectional image comprising a bladder neck and at least one second cross-sectional image comprising verumontanum; according to the first cross section image, a first boundary contour corresponding to the bladder neck is determined, and the first boundary contour covers the sphincter in the urethra; according to the second cross section image, a second boundary contour corresponding to the verumontana is determined, and the second boundary contour covers the verumontana; according to the first boundary contour and the at least one second boundary contour, the ablation protection area in the prostate target area is determined, the problem that definition of a functional structure depends on subjective judgment of clinical experience is solved, the quantitative protection standard of the functional anatomical axis from the bladder neck to the prostatic urethra to the verumontana is achieved, and the protection effect is improved. The risk of urination function impairment and sexual function impairment induced by transurethral ablation operation is effectively controlled.

A stimulation apparatus for use in treating sexual dysfunction, comprising: at least one pair of electrodes configured to deliver low level electrical impulses to muscles within at least one of a hip flexor, lower abdominal and thigh muscle group; a vibrating device for placement on a sexual organ of the user; and a controller comprising a stimulation circuit, a processor and a memory, the stimulation circuit operatively coupled to the pair of electrodes and vibrating device, the processor being configured to execute instructions stored in memory to: in use, control the stimulation circuit to simultaneously actuate the vibrating device and electrodes for inducing orgasm by the user; and wherein, in use, an intensity of at least one of the vibrating device and electrical impulses are dynamically varied.

An apparatus for treating a sexually dysfunctional male patient is provided. The apparatus comprising an implantable vibrator adapted to be implanted within at least one corpus cavernosum of a human patient, wherein said vibrator is adapted to cause vibration in at least one of the corpus cavernosum for stimulating the sexually responsive tissue of the penis.

This invention presents a disposable male hydrogel patch designed to delay ejaculation and prolong erection time while minimizing the impact on sexual pleasure. The patch features an ergonomically designed backing with specific curvatures, a drug-loaded strip divided into central and side zones, and an optional hydrogel coating for sustained drug release. The central zone contains a drug mixture that inhibits the dorsal nerve of the penis, while the side zones promote vasodilation related to erection. The backing includes the adjustment hole for adaptive fitting and is made of a multi-layer composite that integrates breathability, waterproofing, moisture absorption, and fixation. The drug-loaded strip incorporates herbal extracts and synthetic compounds to target the nervous system, vascular system, and endocrine system. Discrete protruding arrays at the coronal sulcus recess enhance drug delivery. This novel, multi-angle approach comprehensively improves sexual function and quality of life, making it a significant innovation in male sexual health.

Disclosed herein is, among other things, a soft gel vaginal pharmaceutical composition and dosage form containing solubilized estradiol for the treatment of vulvovaginal atrophy (VVA) and female sexual dysfunction (FSD).

The invention provides a traditional Chinese medicine composition for tonifying kidney, strengthening yang and tonifying deficiency for treating male erectile dysfunction and oligospermia and asthenospermia. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 220 to 500 parts of semen cuscutae, 350 to 650 parts of bull penis, 230 to 480 parts of herba epimedii, 210 to 470 parts of herba cistanche, 190 to 450 parts of fructus corni, 180 to 420 parts of tortoise shell, 170 to 400 parts of antler, 160 to 350 parts of hippocampus, 160 to 280 parts of ginseng, 170 to 300 parts of rhizoma polygoni cuspidati, 210 to 380 parts of cortex eucommiae, 160 to 310 parts of okra seed, 130 to 250 parts of pericarpium citri reticulatae, 210 to 450 parts of caulis spatholobi, 250 to 360 parts of caulis sargentodoxae and 180 to 380 parts of rhizoma chuanxiong. The traditional Chinese medicine composition is used for treating male erectile dysfunction and insufficiency of kidney yang, impotence, spermatorrhea, premature ejaculation and sexual dysfunction in oligospermia and asthenospermia, can be used for symptomatically improving the weakness of male middle-aged and elderly people, has a long-term effect and stability after treatment, is superior to other treatment medicines and treatment technologies in modern medicine, and has a wide application prospect. Wide clinical value and commercial value are realized.

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition and application thereof in preparation of a medicine for treating male sexual dysfunction. The traditional Chinese medicine composition is named as' Korean prescription ', and comprises the following components in parts by weight: 5-30 parts of semen cuscutae, 1-20 parts of raspberry, 1-20 parts of semen plantaginis, 1-20 parts of fructus lycii, 1-20 parts of radix morindae officinalis, 1-20 parts of glossy privet fruit, 1-20 parts of dendrobe and 1-20 parts of pogostemon cablin. The invention further provides a preparation method of the traditional Chinese medicine composite preparation. According to the Korean prescription, semen cuscutae, morinda officinalis, raspberry and fructus lycii serve as monarch drugs, glossy privet fruit and dendrobe serve as minister drugs, epimedium serve as assistant drugs, semen plantaginis serves as guide drugs, all the drugs are combined, dredging and tonifying are conducted at the same time, yin strengthening and yang strengthening are conducted at the same time, orifice dredging and essence boosting are conducted, fragrance is combined with depression, and the Korean prescription can be used for treating male sexual dysfunction caused by complex mechanisms such as liver-kidney deficiency, qi stagnation and unfavorable orifice closing.

The application discloses a kind of compositions based on engineering stem cell exosome and its application in treating male sexual dysfunction.The composition includes mesenchymal stem cell exosome modified by genetic engineering, which displays bifunctional fusion polypeptide targeting TβRⅡ and LOXL2 on the surface. The fusion polypeptide integrates TβR-PEP with LOXL2-PEP through flexible linker, and introduces HIV-TAT penetrating peptide and self-assembly motif, forms nanoparticles to extend half-life. In vitro experiments show that the inhibition efficiency of the fusion polypeptide on TβRⅡ and LOXL2 is significantly better than that of single polypeptide, and can synergistically reverse fibrosis and promote angiogenesis. Animal experiments confirm that exosome loaded with fusion polypeptide significantly improves the erectile function of diabetic ED rats. The application provides a radical treatment scheme for male sexual dysfunction through double-target synergistic, long-acting delivery and multi-effect repair mechanism.

The invention relates to the technical field of stem cell medicines, in particular to a mesenchymal stem cell composition for treating prostate diseases as well as a preparation method and application of the mesenchymal stem cell composition. The mesenchymal stem cell composition for treating the prostate diseases, disclosed by the invention, is prepared from mesenchymal stem cells subjected to hypoxia treatment and an anti-inflammatory peptide WYPWMKKHRRRRRRRR. The prostate diseases are selected from prostatitis, prostate calcification, sexual function improvement, frequent micturition, urgent micturition and the like. The mesenchymal stem cell composition disclosed by the invention can be used for remarkably improving symptoms of prostate diseases and is remarkable in curative effect.

A neuromodulation system, device, and method are disclosed. In an embodiment, a neuromodulation system includes a processor, a signal generator, a first electrode, and a second electrode. The processor in cooperation with the signal generator, the first electrode, and the second electrode are configured to deliver a transcutaneous stimulation to a mammal. The transcutaneous stimulation is configured by the processor for inducing voluntary movement in the mammal. The first electrode is positioned transcutaneously on a spinal cord and / or spinal cord dorsal roots of the mammal. Additionally, the second electrode is placed transcutaneously on or over at least one of the spinal cord and / or the spinal cord dorsal roots, a muscle, a nerve, or on or near a target end organ or bodily structure of the mammal.

The invention discloses a preparation process and application of an astaxanthin, lycopene and procyanidine compound preparation for resisting aging and preventing prostatic diseases, and belongs to the field of health care products and biological medicines. The preparation is prepared from the following components in parts by weight: 1-10 parts of astaxanthin, 5-30 parts of procyanidine, 2-15 parts of lycopene, 0.5-3 parts of black cumin seed oil, 3-8 parts of phyllanthus emblica extract and 1-5 parts of South African drunken solanum extract, and is prepared by an efficient wet granulation technology. Through the synergistic effect of all the components, the antioxidant activity, the anti-inflammatory activity and the anti-cancer activity are remarkably improved, and the double effects of resisting aging and preventing and treating prostate diseases are achieved. Experiments show that the hydroxyl free radical scavenging rate of the compound preparation is increased by 2.3 times compared with that of a single prescription, inflammatory factors of a prostatitis model are reduced by 68%, the antioxidant capacity of skin is improved by 55%, and by combining with finasteride, the dosage of chemical drugs can be reduced by 80%, and the risk of sexual dysfunction is reduced. The black cumin seed oil obviously improves the bioavailability (29.7%) of lycopene, the prostate tissue drug concentration is 6.5 times that of blood, and low dosage and high benefit are achieved.

This disclosure provides pharmaceutical compositions, such as compounds of formula Ib or formula IIb or their hydrates, spray-dried pharmaceutical compositions containing compounds of formula Ib or formula IIb or their hydrates, as well as methods for preparing and using the same, for the treatment and / or prevention of one or more of the following functional disorders or disorders: sexual dysfunction, erectile dysfunction, ejaculatory dysfunction, hypoactive sexual desire disorder, mental disorders, and neurological disorders. [Formula 1] TIFF2026529136000063.tif56109

The present disclosure provides methods for treating or managing fibromyalgia and its associated symptoms in a subject in need hereof characterized by an early onset of one or more of: (1) a reduction in widespread pain characterized by about 0.3 or more difference in the LS mean change in the NRS Pain Score; (2) a reduction in sleep disturbance characterized by about 2.9 or more difference in the LS Mean change in PROMIS Sleep Disturbance T-score; (3) a reduction in fatigue characterized by about 2.0 or more difference in the LS Mean change in PROMIS Fatigue T-score; or (4) an improved sleep quality characterized by about 0.5 or more difference in the LS Mean change in NRS Sleep Quality Score, each as compared to placebo, comprising administering to a subject in need thereof 2.8 mg or 5.6 mg cyclobenzaprine HCl once daily in one or more dosage units by transmucosal administration. The present disclosure also provides methods for preventing or avoiding one or more of a clinically meaningful change in mean weight, a clinically meaningful change in mean systolic blood pressure or mean diastolic blood pressure, or a decline in sexual functioning in conjunction with treating or managing fibromyalgia or its associated symptoms in a subject in need thereof, the treatment or management being characterized by the transmucosal administration of cyclobenzaprine HCl in one or more dosage units (e.g., a first dosage unit or a second dosage unit). The cyclobenzaprine HCl of these methods is in the form of a mannitol eutectic (e.g., a 75%±2% by weight cyclobenzaprine HCl and 25%±2% by weight β-mannitol eutectic) and the one or more dosage units further comprise a basifying agent.

The application provides a preparation method of a stem cell exosome composition and application of the stem cell exosome composition in male sexual dysfunction, and the preparation method comprises the following steps: extracting stem cell exosomes; combining the stem cell exosomes with a stabilizing peptide; and preparing a stem cell exosome hydrogel; the stabilizing peptide comprises an amino acid sequence as shown in SEQ ID NO: 1. The stem cell exosome composition obtained by the method can improve the stability of the exosomes, improve the in-vivo bioavailability, prevent and relieve testicular injury, and inhibit inflammatory reactions.

There is provided the use of a composition for the treatment or amelioration of female sexual dysfunction in a subject, wherein the composition comprises volatile and non-volatile solvents, the volatile solvents comprising a lower alcohol and water and the non-volatile solvents comprising a polyhydric alcohol and a glycol, wherein the composition is free of glyceryl trinitrate (GTN), an acetylcholinesterase inhibitor, a vasodilator and oestrogen.