74 results about "Sexual functioning" patented technology

The present application relates to the technical field of stem cell medicine, in particular to a mesenchymal stem cell composition for treating prostate diseases and a preparation method and application thereof. The mesenchymal stem cell composition for treating prostate diseases comprises mesenchymal stem cells treated by low oxygen and an anti-inflammatory peptide WYPWMKKHHRRRRRRRRR. The prostate diseases are selected from prostatitis, prostate calcification, sexual function improvement, frequent urination and urgency, etc. The mesenchymal stem cell composition can significantly improve the symptoms of prostate diseases, and the curative effect is remarkable.

The present invention relates to an oral extract composition comprising Shatavari (Asparagus racemosus Willd.) and Fenugreek (Trigonella foenum-graecum L.) extract composition, and its process of preparation. Also relates to the oral extract composition formulation comprising with synergistic combinations of the Shatavari (Asparagus racemosus Willd.) and Fenugreek (Trigonella foenum-graecum L.) in suitable doses and at least one nutraceutically and / or pharmaceutically accepted excipient for, improvement, and maintenance of women health more preferably in improving of hot flashes, night sweats, poor sleep, anxiety, sexual dysfunction, mood changes, Genitourinary symptoms in overall improving the quality of life, serum estradiol, progesterone, follicle stimulating hormone (FSH), and cortisol during the period of menopause (perimenopause and menopause). The oral extract composition formulation comprising with synergistic combinations of the Shatavari (Asparagus racemosus Willd.) and Fenugreek (Trigonella foenum-graecum L.) in suitable doses and at least one nutraceutically and / or pharmaceutically accepted excipient is used for improving Brain-derived neurotrophic factor (BDNF) levels in women during the period of menopause. The present invention, further related to the extraction process of Shatavari (Asparagus racemosus Willd.) and Fenugreek (Trigonella foenum-graecum L.), also provides the process for the preparation of formulation composition. This invention further relates to the extraction process from Shatavari (Asparagus racemosus Willd.) and Fenugreek (Trigonella foenum-graecum L.) either as individual herbs or co-extraction of the two herbs or mixing the extracts at various stages of the individual extracts.

The present invention belongs to the fields of medicine, health care and food, and specifically relates to use of a composition of alcohol and a cooling agent in regulating sexual functions, protecting cardiovascular and cerebrovascular systems, promoting regeneration of liver cells, preventing and / or treating tumors, and improving immunity and sleep quality. The technical problem to be resolved by the present invention is to provide the use of a composition of alcohol and a cooling agent in regulating sexual functions, protecting cardiovascular and cerebrovascular systems, promoting regeneration of liver cells, preventing and / or treating tumors, and improving immunity and sleep quality. The composition of the present invention includes the alcohol and the cooling agent. Further, the composition includes an organic acid. The alcohol in the composition is 1%vol-99%vol, and the cooling agent therein is 0.05ppm-500ppm. The composition provided according to the present invention can play the role of regulating sexual functions, protecting cardiovascular and cerebrovascular systems, promoting regeneration of liver cells, preventing and / or treating tumors, and improving immunity and sleep quality in a short period.

The invention relates to steroids and / or functional analogues thereof for use in a method of treating an individual suffering from sexual dysfunction. Said steroids may be combined with an effective dosage of oxytocin and / or a functional analogue thereof.

The invention belongs to the technical field of traditional Chinese medicine compositions, and particularly relates to a traditional Chinese medicine composition for invigorating kidney, strengthening yang and resisting fatigue and a preparation method and application thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 20 to 30 parts of cornu cervi pantotrichum, 20 to 30 parts of penis cervi, 15 to 25 parts of radix rehmanniae recen, 10 to 20 parts of rhizoma dioscoreae, 5 to 15 parts of cortex moutan, 15 to 25 parts of poria cocos, 10 to 20 parts of rhizoma alismatis and 5 to 15 parts of tetrapanax papyriferus. The traditional Chinese medicine composition prepared by the invention aims at soreness and weakness of waist and knees, intolerance of cold and cold limbs and sexual dysfunction caused by insufficiency of kidney-yang, treats both symptoms and root causes through the compatibility of warming yang and nourishing yin, and can enhance immunity, improve chronic fatigue and relieve physical exhaustion at the same time.

This invention provides a disposable underwear with a traditional Chinese medicine interlayer for regulating male sexual function, belonging to the field of disposable underwear technology. It includes: an underwear body, pant legs, a waistband, and a crotch protector. The crotch protector is located in the crotch area of ​​the underwear body, forming an interlayer structure filled with a traditional Chinese medicine composition for regulating male sexual function. The inner surface of the crotch protector has a breathable fabric with multiple air vents. The breathable fabric is adhered to the traditional Chinese medicine composition layer. The skin-friendly non-woven breathable fabric on the inner side of the crotch protector is in direct contact with human skin. The evenly distributed air vents allow the effective components of the traditional Chinese medicine composition to slowly penetrate and release, directly acting on acupoints and skin in the male groin area to achieve a regulating effect. The array of breathable holes on the outer side of the crotch protector connects to the interior of the interlayer, forming an internal and external breathable channel, accelerating the volatilization and penetration of the traditional Chinese medicine components, and promptly wicking away sweat from the groin area, avoiding stuffiness and dampness, and ensuring dryness while wearing the underwear.

A male sexual function therapeutic instrument belongs to the technical field of male sexual function disease health care instruments. The male sexual function therapeutic instrument solves the problems that an existing male sexual function therapeutic instrument is complex in structure and operation and simple in function. A face shell and a bottom shell are connected in a matched mode to form a cavity, a water tank, an air pump, a water pump and a main control board are arranged in the cavity, the water pump is connected with the water tank in a matched mode, the main control board, the air pump and the water pump are connected with a treatment head socket in a matched mode, and an interface of the treatment head socket penetrates through the face shell and the bottom shell to be arranged outside the face shell and the bottom shell. One end of the treatment head assembly is cooperatively connected with the treatment head socket, the treatment head assembly is connected with a treatment cylinder, the water tank is connected with the treatment head assembly through a water pump, and the main control board is provided with an electromagnetic valve and a DC socket. The male sexual function therapeutic apparatus is simple in structure and has more practical functions.

The invention discloses a construction method, system, equipment, product and medium for an ablation protection area, and the method comprises the steps: obtaining a cross-sectional image set of a prostate target area, the cross-sectional image set comprising a first cross-sectional image comprising a bladder neck and at least one second cross-sectional image comprising verumontanum; according to the first cross section image, a first boundary contour corresponding to the bladder neck is determined, and the first boundary contour covers the sphincter in the urethra; according to the second cross section image, a second boundary contour corresponding to the verumontana is determined, and the second boundary contour covers the verumontana; according to the first boundary contour and the at least one second boundary contour, the ablation protection area in the prostate target area is determined, the problem that definition of a functional structure depends on subjective judgment of clinical experience is solved, the quantitative protection standard of the functional anatomical axis from the bladder neck to the prostatic urethra to the verumontana is achieved, and the protection effect is improved. The risk of urination function impairment and sexual function impairment induced by transurethral ablation operation is effectively controlled.

A stimulation apparatus for use in treating sexual dysfunction, comprising: at least one pair of electrodes configured to deliver low level electrical impulses to muscles within at least one of a hip flexor, lower abdominal and thigh muscle group; a vibrating device for placement on a sexual organ of the user; and a controller comprising a stimulation circuit, a processor and a memory, the stimulation circuit operatively coupled to the pair of electrodes and vibrating device, the processor being configured to execute instructions stored in memory to: in use, control the stimulation circuit to simultaneously actuate the vibrating device and electrodes for inducing orgasm by the user; and wherein, in use, an intensity of at least one of the vibrating device and electrical impulses are dynamically varied.

An apparatus for treating a sexually dysfunctional male patient is provided. The apparatus comprising an implantable vibrator adapted to be implanted within at least one corpus cavernosum of a human patient, wherein said vibrator is adapted to cause vibration in at least one of the corpus cavernosum for stimulating the sexually responsive tissue of the penis.

This invention presents a disposable male hydrogel patch designed to delay ejaculation and prolong erection time while minimizing the impact on sexual pleasure. The patch features an ergonomically designed backing with specific curvatures, a drug-loaded strip divided into central and side zones, and an optional hydrogel coating for sustained drug release. The central zone contains a drug mixture that inhibits the dorsal nerve of the penis, while the side zones promote vasodilation related to erection. The backing includes the adjustment hole for adaptive fitting and is made of a multi-layer composite that integrates breathability, waterproofing, moisture absorption, and fixation. The drug-loaded strip incorporates herbal extracts and synthetic compounds to target the nervous system, vascular system, and endocrine system. Discrete protruding arrays at the coronal sulcus recess enhance drug delivery. This novel, multi-angle approach comprehensively improves sexual function and quality of life, making it a significant innovation in male sexual health.

Disclosed herein is, among other things, a soft gel vaginal pharmaceutical composition and dosage form containing solubilized estradiol for the treatment of vulvovaginal atrophy (VVA) and female sexual dysfunction (FSD).

The invention provides a traditional Chinese medicine composition for tonifying kidney, strengthening yang and tonifying deficiency for treating male erectile dysfunction and oligospermia and asthenospermia. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 220 to 500 parts of semen cuscutae, 350 to 650 parts of bull penis, 230 to 480 parts of herba epimedii, 210 to 470 parts of herba cistanche, 190 to 450 parts of fructus corni, 180 to 420 parts of tortoise shell, 170 to 400 parts of antler, 160 to 350 parts of hippocampus, 160 to 280 parts of ginseng, 170 to 300 parts of rhizoma polygoni cuspidati, 210 to 380 parts of cortex eucommiae, 160 to 310 parts of okra seed, 130 to 250 parts of pericarpium citri reticulatae, 210 to 450 parts of caulis spatholobi, 250 to 360 parts of caulis sargentodoxae and 180 to 380 parts of rhizoma chuanxiong. The traditional Chinese medicine composition is used for treating male erectile dysfunction and insufficiency of kidney yang, impotence, spermatorrhea, premature ejaculation and sexual dysfunction in oligospermia and asthenospermia, can be used for symptomatically improving the weakness of male middle-aged and elderly people, has a long-term effect and stability after treatment, is superior to other treatment medicines and treatment technologies in modern medicine, and has a wide application prospect. Wide clinical value and commercial value are realized.

The application discloses a kind of compositions based on engineering stem cell exosome and its application in treating male sexual dysfunction.The composition includes mesenchymal stem cell exosome modified by genetic engineering, which displays bifunctional fusion polypeptide targeting TβRⅡ and LOXL2 on the surface. The fusion polypeptide integrates TβR-PEP with LOXL2-PEP through flexible linker, and introduces HIV-TAT penetrating peptide and self-assembly motif, forms nanoparticles to extend half-life. In vitro experiments show that the inhibition efficiency of the fusion polypeptide on TβRⅡ and LOXL2 is significantly better than that of single polypeptide, and can synergistically reverse fibrosis and promote angiogenesis. Animal experiments confirm that exosome loaded with fusion polypeptide significantly improves the erectile function of diabetic ED rats. The application provides a radical treatment scheme for male sexual dysfunction through double-target synergistic, long-acting delivery and multi-effect repair mechanism.

The invention relates to the technical field of stem cell medicines, in particular to a mesenchymal stem cell composition for treating prostate diseases as well as a preparation method and application of the mesenchymal stem cell composition. The mesenchymal stem cell composition for treating the prostate diseases, disclosed by the invention, is prepared from mesenchymal stem cells subjected to hypoxia treatment and an anti-inflammatory peptide WYPWMKKHRRRRRRRR. The prostate diseases are selected from prostatitis, prostate calcification, sexual function improvement, frequent micturition, urgent micturition and the like. The mesenchymal stem cell composition disclosed by the invention can be used for remarkably improving symptoms of prostate diseases and is remarkable in curative effect.

This disclosure provides pharmaceutical compositions, such as compounds of formula Ib or formula IIb or their hydrates, spray-dried pharmaceutical compositions containing compounds of formula Ib or formula IIb or their hydrates, as well as methods for preparing and using the same, for the treatment and / or prevention of one or more of the following functional disorders or disorders: sexual dysfunction, erectile dysfunction, ejaculatory dysfunction, hypoactive sexual desire disorder, mental disorders, and neurological disorders. [Formula 1] TIFF2026529136000063.tif56109

The application provides a preparation method of a stem cell exosome composition and application of the stem cell exosome composition in male sexual dysfunction, and the preparation method comprises the following steps: extracting stem cell exosomes; combining the stem cell exosomes with a stabilizing peptide; and preparing a stem cell exosome hydrogel; the stabilizing peptide comprises an amino acid sequence as shown in SEQ ID NO: 1. The stem cell exosome composition obtained by the method can improve the stability of the exosomes, improve the in-vivo bioavailability, prevent and relieve testicular injury, and inhibit inflammatory reactions.

The invention provides a preparation method and application of a stem cell preparation for repairing male sexual dysfunction. The preparation method comprises the following steps: extraction and primary culture of mesenchymal stem cells; regulating and controlling secretion signals of the mesenchymal stem cells; and preparing the preparation. According to the preparation method of the stem cell preparation for repairing the male sexual dysfunction, the mitochondrial repair signal inducer is added in the mesenchymal stem cell culture stage, and the mitochondrial function repair promoting component is added into the preparation, so that the obtained stem cell preparation can repair the mitochondrial energy metabolism function; the mitochondrial quality control is promoted; the cavernous body tissue microenvironment is improved. The preparation method provided by the invention can achieve the beneficial effects of performing targeted repair on the focus of male sexual dysfunction and improving the treatment and repair efficiency.

The invention relates to the field of medical electric detection, in particular to an adjustable and fixed neuroelectrophysiology male sexual function detection device which comprises two annular copper core wires, an insulating sheath wrapped with the copper core wires and an adapter, the two annular copper core wires are connected with the adapter, an integrally-formed threaded block is further arranged on the outer side surface of the insulating sheath, and the threaded block is connected with the adapter. The threaded block is also provided with a threaded sleeve wrapping the two copper core wires. The end, close to the annular copper core wire, of the threaded sleeve is provided with a gradient gasket. Through the arrangement of the threaded sleeve, the circumference of the annular copper core wire is changed, and the problem that in the prior art, an adhesive tape is needed for fixation is solved. And by arranging the gradient gasket, meat is not clamped when the circumferential diameter of the annular copper core wire is adjusted, and the problem of meat clamping in the prior art is solved.

The invention belongs to the field of Tibetan medicines, and particularly relates to a Tibetan medicine composition for tonifying yang and a preparation method thereof. The Tibetan medicine composition for tonifying yang is prepared from the following raw materials in parts by weight: 120 to 130 parts of pomegranate, 30 to 40 parts of cortex cinnamomi, 15 to 25 parts of fructus amomi rotundus, 10 to 20 parts of fructus piperis longi, 45 to 55 parts of saffron crocus, 35 to 45 parts of chingma abutilon seed, 45 to 55 parts of radix asparagi, 70 to 80 parts of radix angelicae sinensis, 45 to 55 parts of mirabilis himalaica, 70 to 80 parts of fructus tribuli, 70 to 80 parts of snow lotus herb and 70 to 80 parts of five-root concentrated paste. The composition is scientific in formula, standard in preparation, high in safety and free of obvious side effects, sexual dysfunction and accompanying discomfort caused by kidney-yang deficiency can be improved in a targeted mode, and the clinical application effect is remarkable.

The invention provides application of TRMT61A as a target spot in preparation of a medicine for preventing or treating benign prostatic hyperplasia. The TRMT61A is specifically targeted through shRNA, pathogenic signals are blocked from the post-transcriptional level, accurate intervention on benign prostatic hyperplasia is achieved, dependence on androgen pathways is completely avoided, unavoidable sexual dysfunction and other serious side effects of traditional drugs are fundamentally avoided, and the life quality of patients is remarkably improved.

The present disclosure relates generally to compositions and techniques for treating female sexual dysfunction (FSD), including female sexual arousal disorder (FSAD). In some embodiments, a composition, such as a cream, may be applied to the genital organ of a subject. The composition may also contain an active ingredient for the treatment of FSD and / or FSAD, such as sildenafil and / or a pharmaceutically acceptable salt thereof. In addition, certain embodiments described herein generally relate to techniques using such compositions, kits including such compositions, and the like.

The invention provides a penis external supporting device and method for assisting male sexual dysfunction, and belongs to the technical field of medical instruments. The device comprises a sleeve-shaped main body made of a flexible biocompatible material and a built-in plastic deformation metal structure supporting piece, the front end and the rear end of the main body are provided with a first opening and a second opening respectively, the front end opening ensures that the glans penis is exposed to maintain sensitivity, and the internal metal supporting piece can be bent and shaped manually; after shaping, the bottom opening ensures that the ejaculation channel is not pressed, and the supporting force required for maintaining erection of the penis is provided. By means of the composite structure with the soft outer portion and the rigid inner portion and the humanized design with the two ends open, erection is effectively assisted, meanwhile, the physiological comfort level, sensitivity and the normal ejaculation function of a user are guaranteed to the maximum degree, and a safe, non-invasive and effective physical auxiliary instrument is provided for an erectile dysfunction patient.

The invention discloses an anti-fatigue and immunity-enhancing medicinal and edible composition as well as a preparation method and application thereof, and relates to the technical field of medicinal and edible homology. Comprising the following components: astragalus membranaceus, codonopsis pilosula, American ginseng, radix ophiopogonis, hawthorn, smoked plum, schisandra chinensis, ligusticum wallichii, liquorice and mint. Based on the traditional Chinese medicine core theory of tonifying qi, strengthening superficies and tonifying both qi and yin and aiming at the constitution characteristics of deficiency fire and dampness stagnation of modern people, monarch, minister, assistant and guide are creatively recombined, hawthorn and smoked plum are introduced as flavor monarch and minister, the bitter taste of a traditional Chinese medicine beverage is thoroughly subverted by natural tartaric acid, and the instant pleasure is improved by assisting with mint. The traditional Chinese medicine composition has the effects of resisting fatigue, enhancing immunity and comprehensively improving eight sub-health core symptoms such as sleep, memory, appetite, hyperhidrosis and sexual function, and the effective rate reaches 85% or above. And the tea is an epoch-making functional beverage with classical wisdom, modern science and technology and extreme taste, can meet the conditioning requirements of sub-health people, and can also be used as a daily healthy beverage for common people.

The present disclosure provides methods for treating or managing fibromyalgia and its associated symptoms in a subject in need hereof characterized by an early onset of one or more of: (1) a reduction in widespread pain characterized by about 0.3 or more difference in the LS mean change in the NRS Pain Score; (2) a reduction in sleep disturbance characterized by about 2.9 or more difference in the LS Mean change in PROMIS Sleep Disturbance T-score; (3) a reduction in fatigue characterized by about 2.0 or more difference in the LS Mean change in PROMIS Fatigue T-score; or (4) an improved sleep quality characterized by about 0.5 or more difference in the LS Mean change in NRS Sleep Quality Score, each as compared to placebo, comprising administering to a subject in need thereof 2.8 mg or 5.6 mg cyclobenzaprine HCl once daily in one or more dosage units by transmucosal administration. The present disclosure also provides methods for preventing or avoiding one or more of a clinically meaningful change in mean weight, a clinically meaningful change in mean systolic blood pressure or mean diastolic blood pressure, or a decline in sexual functioning in conjunction with treating or managing fibromyalgia or its associated symptoms in a subject in need thereof, the treatment or management being characterized by the transmucosal administration of cyclobenzaprine HCl in one or more dosage units (e.g., a first dosage unit or a second dosage unit). The cyclobenzaprine HCl of these methods is in the form of a mannitol eutectic (e.g., a 75% ± 2% by weight cyclobenzaprine HCl and 25% ± 2% by weight β‑mannitol eutectic) and the one or more dosage units further comprise a basifying agent.

The pharmaceutical composition for treating dementia, comprising a mephenesin analogue compound and / or a compound with a carbamate structure. A therapeutic drug that can fundamentally treat dementia without causing side effects, such as an increase / decrease in body weight, loss of appetite, sexual debility, and symptoms of withdrawal can be provided with the pharmaceutical composition defined in the present invention. Combining this pharmaceutical composition with other pharmaceutical compositions, including cholinesterase inhibitors, can provide the most certain treatment method according to the symptoms.

The invention relates to a combination of testosterone and / or a functional analogue thereof and oxytocin and / or a functional analogue thereof for administration to subjects in need thereof for improvement of a cognitive disorder, sexual dysfunction, or mood disorder that can advantageously be applied with Repetitive Transcranial Magnetic Stimulation (rTMS) and / or cognitive training.

The invention belongs to the technical field of disease diagnosis, and discloses an application method of a transrectal ultrasound-guided injection technology in low rectal cancer anterior wall operation gap separation, which comprises the following steps of: reconstructing a three-dimensional anatomical model according to MRI (Magnetic Resonance Imaging) before an operation, and importing an image terminal to generate an initial path; the ultrasonic probe is slowly pushed to the lower edge plane of the tumor in the operation, and the system automatically locks the front wall expected separation layer; a needle inserting point is selected on the visual interface, the curved needle slowly moves along a planned path, and pressure and echo signals are synchronously displayed; after entering the target layer, firstly injecting a trace imaging liquid to confirm the expansion of the layer surface, and then continuously injecting a separating liquid to form a stable water cushion to push away the tumor anterior wall and the prostate or vagina posterior wall; after liquid stripping is completed, a surgeon carries out energy instrument incision and suture along an opened gap, so that the anus protection rate is improved, and the risk of bladder and sexual function injury is reduced.

The polypeptide OR-D-3 capable of improving the sexual function is obtained from oysters through enzymolysis screening and identification, and the polypeptide can improve the cell survival rate, increase the secretion amount of TM3 cell testosterone and increase the NO concentration of TM3 cell culture supernatant. After the polypeptide is applied to a mouse, the riding latency period and the riding frequency can be remarkably prolonged, the content of testosterone in serum is increased, no obvious toxicity exists, the sexual capacity of the mouse is remarkably improved, and a remarkable effect is achieved. The polypeptide has a good effect after being prepared into a medicine, and the application prospect is wide.