69 results about "Dry-powder inhaler" patented technology

The present invention provides a dry powder inhaler comprising: one or more doses of powdered medication; an outlet through which a user may inhale a dose of medication; an airway, and a mixing element located in the airway When a user inhales on the outlet, medication is entrained in an air flow and flows through the airway and out through the outlet. The mixing element is in the form of three generally orthogonal generally circular discs with a common centre.

The present invention provides a dry powder inhaler comprising: one or more doses of powdered medication; an outlet through which a user may inhale a dose of medication; an airway comprising a vortex chamber having a wall, an exit, a powder inlet channel, and optionally one or more bypass inlet channels, wherein the powder inlet channel and or the bypass inlet channels are tangential to the wall. A mesh is located at the exit of the vortex chamber. The mesh is formed from circumferential elements and radial elements which together define a plurality of openings. When a user inhales on the outlet, medication is entrained in an air flow and flows through the vortex chamber and the mesh in the airway and out through the outlet.

A process for manufacturing a Treprostinil-diketopiperazone dry powder for pharmaceutical use by spray drying a suspension without need to dissolve Treprostinil in an alcohol solution prior to processing. In some embodiments, the dry powder is for oral inhalation for pulmonary delivery using a dry powder inhaler.

The present invention provides a dry powder inhaler comprising one or more containers of powdered medication for inhalation; an outlet through which a user may inhale a dose of medication; and an airway comprising a cyclone chamber The cyclone chamber has a tangential powder inlet channel for supplying the powdered medication from at least one of the one or more dose containers; one or more tangential bypass inlet channels; and an axial exit opening connected to the outlet. When a user inhales on the outlet to create an air flow, medication is entrained in the air flow and flows through the airway via the cyclone chamber, and out through the outlet. The invention is characterized in that the airway comprises a grate between the dose container and the powder inlet channel that prevents large agglomerates of powder from entering the powder inlet channel.

The invention discloses a rotating mechanism, a dose protection mechanism, a respiration triggering device and a dry powder inhaler. The rotating mechanism is applied to the respiration triggering device and comprises a rotating shaft, a rotating shaft and a rotating shaft, the baffle is connected to the outer side surface of the rotating shaft; wherein the rotating mechanism can rotate between a first position and a second position, and when the rotating mechanism is located at the first position, a first airflow channel of the respiration triggering device is blocked; when the baffle moves from the first position to the second position, the baffle rotates around the rotating shaft to open the first airflow channel. Through the arrangement, the problem that in the prior art, the medicine powder depolymerization effect is poor can be effectively solved.

The present invention belongs to the technical field of medical devices, and particularly relates to a dry powder inhalation device with a rotating multi-capsule channel that is sequentially opened for inhalation, which is mainly used for administering in the form of a dry powder inhalant, and includes: a mouthpiece; a housing, a chamber is formed inside the housing; a plurality of capsule compartments are formed in the chamber and can be communicated with the mouthpiece; a diversion part is movably arranged between the mouthpiece and the plurality of capsule compartments to communicate the mouthpiece with one capsule compartment; a driving part is connected to the housing and the diversion assembly, and the driving part can rotate relative to the housing to drive the diversion assembly to move between the mouthpiece and the plurality of capsule compartments, so that different capsule compartments are communicated with the mouthpiece, solving the problem that: in the existing multi-capsule powder inhaler, when the user inhales the drug through the mouthpiece, the mouthpiece is communicated with each capsule compartment, resulting in the user's suction being dispersed into each capsule compartment, making it difficult for the user to inhale the drug, and thus reducing the inhalation efficiency.

The dry powder inhaler comprises an inhalation channel (8) connected to a mouthpiece (4), a container (7) for storing the powder drug, a deaggregation device (25) having a vortex chamber (26) disposed at an end of the inhalation channel (8), and a metering device (14) comprising a shuttle (16) having a dosing recess (15). The shuttle (16) is movable between a filling position in which the dosing recess (15) is aligned with the opening (17) of the container (7) and an inhalation position in which the dosing recess (15) is aligned with the vortex chamber (26). The opening (17) of the container (7) is elongated along a major axis (Y-Y), the dosing recess (15) is elongated along a principal axis (X-X), and when the shuttle (16) is in the filling position, an edge (27) of the opening (17) of the container (7) surrounds the dosing recess (15).

The present invention belongs to the technical field related to medical equipment, and discloses a dry powder inhaler, which includes a housing, a first nozzle pitch adjustment mechanism, a positioning spring, and a positioning bead. The first nozzle pitch adjustment mechanism is movably disposed within the housing; the positioning spring is disposed within the first nozzle pitch adjustment mechanism; the positioning bead is partially disposed within the first nozzle pitch adjustment mechanism and contacts the positioning spring; the positioning spring is used to keep the side of the positioning bead away from the positioning spring against the inner wall of the housing; wherein one of the positioning bead is partially accommodated within the wall of the housing; and the first nozzle pitch adjustment mechanism adjusts the position of the nozzle by rotating relative to the housing. The present invention solves the problem of the nozzle angle being unadjustable.

The present disclosure provides aerosol properties of a powder composition applied by a dry powder inhaler and a spray drying method. Also provided is a method for treating pulmonary hypertension (PH) in a patient comprising administering an effective amount of the powder composition once a day to the lung of the patient by inhalation with the dry powder inhaler. Further provided is a system for treating PH using the powder composition and the dry powder inhaler.

The invention relates to a dry-powder inhaler comprising: a body (110); a mouthpiece (120); a chamber (111); and a reservoir (10) containing a dose of dry powder and having at least one lateral outlet orifice (11), the reservoir being arranged in the chamber, the diameter of the reservoir being less than the diameter of the chamber, such that the reservoir can move in the chamber; the body having tangential channels (115a-115c) suitable for bringing a flow of inhalation air tangentially into the chamber, thereby causing the reservoir to move orbitally in the chamber during inhalation, the reservoir having at least one internal profile (17a, 17b) for guiding and / or dispersing the powder on expulsion by the flow of inhalation air.

A system and method for monitoring use of a respiratory device, such as a dry powder inhaler, comprise a tracking module adaptable to be temporarily mounted to the respiratory device, and reusable with other respiratory devices. Inhalation medication delivery and air flow through the respiratory device are monitored for the determination of proper respiratory device use. Other data such as location, orientation, shaking, and environmental data are sensed and stored. Low power devices are used to conserve battery power. An app for connection with mobile devices is provided.

This invention relates to the field of filling equipment technology and discloses a storage-type automated filling equipment for dry powder inhalers. The equipment includes a workbench, a frame fixedly mounted on the top of the workbench, a mounting frame mounted on the top of the frame, a support frame fixedly mounted on the top of the mounting frame, and a drive motor mounted on the top of the support frame. The output shaft of the drive motor passes through the interior of the mounting frame and is fitted with a track. A rotating rod is rotatably mounted inside the mounting frame, and the bottom of the rotating rod passes through the interior of the mounting frame and is fixedly fitted with a rotating wheel. In this invention, a camera, a rotating wheel, a positioning wheel, a drive motor, and an electric push rod work together. The electric push rod pushes the positioning wheel to clamp the filling bottle, the drive motor drives the rotating wheel to rotate and adjust the bottle angle, and the camera identifies and positions the bottle in real time, accurately correcting the bottle placement to ensure precise alignment between the filling nozzle and the discharge port of the filling component.

The invention provides a unit dose dispenser in the form of a blister containing a dry powder for inhalation. The blister comprises a base material in which a cavity is formed comprising a bowl that contains the powder and a channel that opens into the bowl. The channel contains a tube that has separate sections that provide an air outlet and an air inlet. The air outlet is further from the bowl than the air inlet. The upper side of the tube is flat and level with the top of the channel A lid material, such as a foil or foil laminate, seals the cavity. The blister has a detachable portion which, when removed, exposes the air inlet and the air outlet. A process for making the unit dose dispensers is also provided, which is based on the conventional process for manufacturing blister strips for dry powder inhalers.

The invention relates to the technical field of dry powder inhalers, and discloses a dry powder inhaler with a single capsule and double capsules switchable, the dry powder inhaler comprises a main body and a suction nozzle rotationally connected with the main body, two accommodating cavities and a communicating cavity communicated with the accommodating cavities are integrally formed in an inner cavity of the main body, and an air port communicated with the communicating cavity is formed in the side wall of the main body; a movable cavity is concavely formed in the side wall of the main body, a sliding shell is slidably connected in the movable cavity, a pricking needle is fixedly arranged on one side of the sliding shell, a spring is fixedly arranged between the sliding shell and the movable cavity, a movable hole is formed between the movable cavity and the communicating cavity in a communicating mode, the movable hole and the pricking needle are coaxially arranged, and the head of the pricking needle is located in an inner cavity of the movable hole; a medicine feeding channel communicated with the containing cavity is formed in the middle of the suction nozzle, a filter screen assembly is movably installed on the lower portion of the medicine feeding channel, a compressible elastic plate is arranged on the suction nozzle, and the filter screen assembly can be pushed to be separated from the medicine feeding channel by pressing the elastic plate. The main body is integrally machined and formed, the number of components is small, the filter screen assembly can be easily and rapidly detached for cleaning, and daily use is facilitated.

The present invention provides a dry powder inhaler comprising one or more doses of powdered medication comprising a pharmaceutically active ingredient; an outlet, such as a mouthpiece or nose piece, through which a user may inhale a dose of medication; and an airway comprising a cyclone chamber. The cyclone chamber has one tangential powder inlet channel, two tangential bypass (clean) air inlet channels and an axial exit opening connected to the outlet of the inhaler. The cross-sectional area of the powder inlet channel is not equal to the cross-sectional areas of the bypass inlet channels. When a user inhales on the outlet to create an air flow, medication is entrained in the air flow and flows through the airway via the cyclone chamber, and out through the outlet.

The invention discloses a carrier-free mometasone furoate dry powder inhaler and a preparation method thereof, and relates to the technical field of pharmaceutical preparations, the carrier-free mometasone furoate dry powder inhaler comprises mometasone furoate and an excipient, and the preparation method comprises the following steps: firstly, mixing mometasone furoate and the excipient according to a mass ratio of 10: 90-90: 10, transferring into a beaker, adding a proper amount of water, stirring, and carrying out suction filtration; adding an ethanol-water mixed solution, and stirring until solids are completely dissolved to obtain a spray-dried raw material solution; carrying out spray drying on the spray drying raw material solution by adopting a spray dryer, and collecting a product after drying to obtain microspheres, namely the carrier-free mometasone furoate dry powder inhalant. According to the carrier-free mometasone furoate dry powder inhalant, lactose does not need to be used as a carrier, the allergy risk possibly caused by lactose is avoided, meanwhile, a microsphere structure with the surface wrinkled is formed through a spray drying technology, the medicine mainly exists in an amorphous state, and the dispersity and solubility of mometasone furoate are remarkably improved.

A dry powder inhaler for providing pharmaceutically active particles includes a mouthpiece portion removably coupled to a distal end portion. The mouthpiece portion extends between the mouthpiece end and a first mating end. The distal end portion extends between a second mating end and the distal end. A capsule cavity is defined within the first mating end. An airflow element is disposed within the distal end portion and extends a longitudinal length to the capsule cavity. The airflow element includes an airflow channel extending the longitudinal length of the airflow channel and non-parallel with the longitudinal axis, the airflow channel directs inlet air into the capsule cavity, and a resealable membrane configured to reseal when a piercing element is withdrawn from the resealable membrane.

This disclosure provides a dry powder composition of treprostol prodrug and a method of treating pulmonary hypertension (e.g., pulmonary arterial hypertension or PH associated with interstitial lung disease) in patients in need using said dry powder composition. The dry powder composition comprises: (a) about 0.5 wt% to about 5 wt% of a compound, its stereoisomers, or a pharmaceutically acceptable salt thereof; (b) about 10 wt% to about 61 wt% of leucine; and the remainder is (c) a sugar selected from the group consisting of trehalose and mannitol. The total of (a), (b), and (c) is 100 wt%, and R1 is tetradecyl, pentadecyl, hexadecyl, heptadecanyl, or octadecyl. The method of treating PH comprises administering an effective amount of the dry powder composition to the lungs of the patient by inhalation via a dry powder inhaler during an administration period.

In Figure 1, an inhaler has a compressed air tank (1) with air inlet (2) and air outlet (3) valves. The outlet valve is provided with a nozzle (6) with two injection holes (13) and (14), the medicine injection pipe (4) is provided with a medicine hopper (11), and the detachable suction nozzle (5) is provided with a flange (8) and an inner short column (9) which sequentially form an injection mechanism. A medication strip (26) is located within the medication channel of the cross arm (27). A depressible puncture needle (29) disposed in a spring chamber (28) pierces the strip of medicament such that medicament falls into the medicament hopper (11) and into the injection tube bottom (15). The air inlet (18) has a bellows (48) for charging compressed air. During use, the air box is inflated firstly, and then the medicine strip (26) is punctured. The mouthpiece is held in the mouth, inhaled and depressed the outlet valve (3), whereby a soft laminar flow with a drug spray (49) and a peripheral low drug concentration channel (50) will flow into the lung.

The invention discloses an airway structure, a dry powder inhaler and a dose protection mechanism. The air channel structure comprises a shell assembly provided with an external air inlet, and one end of the external air inlet is communicated with the external atmosphere; the air channel bin is arranged in the shell assembly, and the air channel bin is provided with an air inlet; the first airflow channel is arranged in the shell assembly; the third airflow channel is arranged in the shell assembly; when the negative pressure in the air channel bin is smaller than or equal to a preset threshold value, the third air flow channel is opened, the first air flow channel is blocked, and the third air flow channel communicates with the air inlet of the air channel bin and the external atmosphere. When the negative pressure in the air channel bin is larger than a preset threshold value, the first air flow channel is opened, the third air flow channel is blocked, and the first air flow channel communicates with the air inlet of the air channel bin and the external atmosphere. Through the arrangement, the problems that in the prior art, medicine powder is not discharged thoroughly, and the emptying utilization rate is low can be effectively solved, and the depolymerization effect of the medicine powder can be improved.

The invention discloses a winding device and a dry powder inhaler. The winding device comprises a tape winding rod, the tape winding rod comprises a rod-shaped part, a first clamping part and a second clamping part, the first clamping part and the second clamping part are arranged on the outer side face of the rod-shaped part in a spaced mode, and the rod-shaped part is used for winding a material tape; the tape winding gear is provided with a center hole, is arranged on the outer side face of the rod-shaped part in a sleeving mode and is located between the first clamping part and the second clamping part, the hole wall of the center hole is attached to the outer side face of the rod-shaped part, and the surface, close to the first clamping part, of the tape winding gear makes contact with the first clamping part; and the gasket is mounted between the tape winding gear and the second clamping part and is in contact with the tape winding gear and the second clamping part. Through the arrangement, the winding device can achieve the tape winding compensation effect, is simple in structure and small in size, saves space, can be suitable for a small space structure, is wider in application range, and effectively solves the problems that in the prior art, a tape winding compensation mechanism is complex in structure and large in size, and wastes space.

The invention relates to a single-dose type dry powder administration device, and belongs to the field of dry powder inhalers. Comprising a device body and a medicine bin assembly. Wherein the medicine bin assembly comprises a medicine bin main body, a medicine bin cover, a sealing film and a gasket, the medicine bin main body is used for storing medicine powder, an empty groove is formed in the medicine bin cover, the sealing film is packaged and fixed on the medicine bin cover, and the medicine bin main body and the medicine bin cover are fixed through a buckle; the gasket is arranged between the medicine bin body and the medicine bin cover. By means of the structure, the packaging piece and the medicine powder are separated, the situation that in the packaging process, due to the temperature, the biomacromolecule medicine powder loses activity is avoided, and medicine with the strict requirement for the storage temperature can be treated through a dry powder inhalation means.

The invention discloses inhalation device electronic monitoring equipment for the pneumology department. The inhalation device electronic monitoring equipment comprises a portable shell; the touch screen is used for displaying the video, the time, the medication reminding alarm, the operation prompt information, the evaluation result and the excitation information; the camera is used for recording the operation process of using the inhalation device by the patient in real time; the cloud knowledge base module comprises operation videos and image-text instructions of various pressurized quantitative inhalers, dry powder inhalers and soft fog inhalers; the edge calculation module comprises a video analysis unit, a display control unit, a personalized assessment unit and an excitation interaction unit; wherein the video analysis unit is used for judging whether the effective inspiration volume meets the requirement or not according to the operation process recorded by the camera; and the personalized evaluation unit is used for scoring the operation process of each medication according to a preset personalized evaluation standard. By monitoring and guiding the patient to correctly use the inhalation device, the medication compliance and the treatment effect are improved.

A dry powder inhaler (100) is provided, the dry powder inhaler comprising a housing (101) having a longitudinal extension extending along a longitudinal axis (A), the housing (101) having a distal end (102) and a proximal end (103). The housing (101) comprises at least one outlet (104) and at least one inlet (105), and has a central channel (106) in communication with the at least one outlet (104), the at least one outlet (104) being located adjacent the proximal end (103). The housing (101) further comprises a drug platform (122) disposed upstream of the drug cavity (110) and a transverse end wall (123) located at a distal end of the drug platform (122).

There is provided an apparatus (100) for administering a medicament to a patient, comprising: at least one medicament carrier, wherein closed pockets of the medicament carrier contain a medicament in powder form; and a dispensing mechanism configured to act on the at least one elongated medicament carrier to dispense the medicament carried by the at least one elongated medicament carrier. The apparatus comprises, in particular, a collector with at least one collector window over which a respective opened pocket of the elongated medicament carrier is moved and one conduit extending along a longitudinal axis through the collector from at least one entry section, which comprises the at least one collector window, toward the opening of a mouthpiece of the apparatus.

Dry powder inhalers and methods of manufacturing the same are described. A dry powder inhaler includes a desiccant containing desiccant beads and a protective layer to maintain efficacy of the desiccant beads, an overcap formed to integrally hold the desiccant, a medicant dispensing component containing a dry powder medicant, and where one of the protective layer and the medicant dispensing component includes a piercing mechanism. Attachment of the overcap to the medicant dispensing component causes the piercing mechanism to tear the protective layer and place the desiccant beads in dry powder communication with the dry powder medicant, enabling the desiccant beads to absorb moisture present in the dry powder inhaler.

A respiratory-operated dry powder inhaler (301, 401, 501), the inhaler comprising a planar housing assembled from a stack of planar elements, the planar elements comprising a bottom plate (319, 419, 519), an intermediate plate (318, 418, 518), and an upper plate (317, 417), the planar elements being parallel to each other, and at least one planar element having a projection that forms a disc-shaped air circulation chamber (302) within the stack for deagglomerating an encompassed powdered drug using the energy of the inspiratory stream, the housing comprising a plurality of air supply channels (307), an air supply region for the powder flow, and an inhaler discharge channel (312), the chamber having polygonal side walls (303) extending about a central axis between the upper and bottom walls of the chamber, the central axis extending transversely to the bottom plate, and the height of the chamber being less than its diameter, the respiratory-operated dry powder inhaler.

There is provided an apparatus (100) for administering a medicament to a patient, comprising: a plurality of elongated medicament carriers, wherein closed pockets of the medicament carriers contain a medicament dose in powder form; and a dispensing mechanism configured to act on the plurality of elongated medicament carriers upon an actuation of an manual actuation lever (402) to dispense at least one of the medicament doses carried by the plurality of elongated medicament carriers. An advantageous example is characterized in that the dispensing mechanism comprises a transport mechanism configured to pull one or a plurality of peeled-off lid foils causing a transport of at least one opened pocket of an associated base foil of the one or a plurality of medicament carriers. An advantageous example is characterized in that the medicament carriers are stacked on top of each other in order to share one set of drive components.

There is described herein a dry powder inhaler device (100) for administering a powder by inhalation, comprising: a storage chamber operable to hold a supply of powder; a dosing unit (235) adjacent the storage chamber, the dosing unit comprising a rotatable disc with one or more dosing stations, each dosing station comprising less than 5 dosing holes (250) through the rotatable disc, each dosing hole configured to receive and transfer a metered dose of the powder from the storage chamber to an inhalation channel, wherein each of the dosing holes has a side wall profile comprising a curved section; a pressure plate (240) urged against the dosing unit; and an inhalation channel in fluid communication with the dosing unit, wherein the inhalation channel directs the powder entrained in airflow to a user upon inhalation.