6 results about "Probucol" patented technology

The invention discloses a preparation method of a probucol USP impurity C. The preparation method comprises the following steps: taking 2, 6-di-tert-butylphenol as an initial raw material, and synthesizing an intermediate TM1 through thiocyanation; reducing the intermediate TM1 through lithium aluminum hydride to synthesize an intermediate TM2; the preparation method comprises the following steps: taking 2, 4-di-tert-butylphenol as an initial raw material, and synthesizing an intermediate TM3 through thiocyanation; reducing the intermediate TM3 through lithium aluminum hydride to synthesize an intermediate TM4; and condensing the intermediate TM2, the intermediate TM4 and acetone to obtain the probucol USP impurity C. The probucol USP impurity C preparation method has the advantages that 2, 6-di-tert-butylphenol and 2, 4-di-tert-butylphenol are used as raw materials, the probucol USP impurity C can be prepared through the five-step reaction of thiocyanation, reduction and acetone condensation, the raw materials are easy to obtain, the total yield is high, the cost is low, the technical blank of probucol USP impurity C preparation is filled, and the probucol USP impurity C preparation method is suitable for industrial production. A low-cost and high-quality impurity reference substance can be provided for quality research of probucol, and the probucol impurity detection method is of great significance in guaranteeing safe medication of probucol.

The invention discloses probucol nano targeting particles as well as application and a pharmaceutical composition thereof, and relates to the technical field of pharmacy. The probucol nano targeting particle comprises a polymer formed by Poly (HPDMA-RSM)-PEG-NHS and a kidney targeting peptide, wherein the sequence of the kidney targeting peptide is KCSAVPLC, and the sequence of the kidney targeting peptide is KCSAVPLC. And probucol; wherein in the probucol nanometer targeting particle, the hydrophobic segment of the polymer and probucol are aggregated to form a solid core, the hydrophilic PEG chain of the polymer extends outwards to form a hydration shell layer, and the kidney targeting peptide is exposed on the surface of the probucol nanometer targeting particle. According to the invention, Probucol is encapsulated in PEG nanoparticles coupled with KTP for the first time, so that (1) accurate enrichment of renal tubular epithelium is realized; (2) the ferroptosis pathway is efficiently inhibited; (3) the curative effect is obviously improved. The strategy shows a synergistic protection effect superior to that of a naked drug and other antioxidants in a cis-platinum induced AKI model, and has outstanding creativity and industrial transformation value.

The invention belongs to the technical field of pharmaceutical preparations, and provides a probucol sustained-release capsule for reducing the blood fat level and a preparation method thereof, and the probucol sustained-release capsule is prepared by filling a capsule shell with sustained-release pellets, the sustained-release pellet comprises a blank pellet core, a medicine carrying layer, an isolating layer and a sustained-release layer from inside to outside, wherein the medicine carrying layer comprises probucol and an adhesive in a mass ratio of (200-250): (8-12); the slow-release layer is prepared from eudragit RL PO, a plasticizer, a pore-foaming agent and an anti-sticking agent according to the mass ratio of (250 to 300) to (20 to 25) to (20 to 22) to (10 to 18); the pore-foaming agent is prepared from polyethylene glycol 400 and PVP K25 in a mass ratio of (8-12): (3-5). The probucol sustained-release capsule provided by the invention not only has an excellent sustained-release effect, but also enables drug absorption to be less affected by gastric emptying, reduces stimulation to gastrointestinal tracts, and can improve patient compliance.

The invention relates to a Chinese and western medicine composition for treating hyperlipemia. The invention relates to a probucol and red yeast rice medicinal composition, in particular to a probucol and red yeast rice medicinal composition or a medicine box containing probucol and red yeast rice, and application of the medicinal composition, the medicinal composition or the medicine box in preparation of medicines for treating hyperlipidemia, in particular severe hypertriglyceridemia and severe hypercholesteremia. The pharmaceutical composition, the pharmaceutical composition containing probucol and red yeast rice or the kit containing probucol and red yeast rice contains a small dose of probucol and red yeast rice, and the probucol and red yeast rice are configured in a form of simultaneous administration.

The invention belongs to the technical field of biological medicines, and particularly relates to vitexin-probucol self-assembled nanoparticles as well as a preparation method and application thereof. The nanoparticle is formed by self-assembly of vitexin and probucol, and the mass ratio of vitexin to probucol is 2: (1-5). The nano particles are prepared by adopting a nano precipitation method, and the method specifically comprises the following steps: mixing vitexin and probucol, and dissolving and dispersing in a good solvent to obtain a mixed solution; and adding the obtained mixed solution into a poor solvent, and promoting the vitexin and probucol to be self-assembled to form the nanoparticles by utilizing a solvent replacement effect. The nanoparticles have the advantages of high drug loading capacity, synergistic anti-inflammation and anti-oxidation, long-acting circulation and the like, and can effectively treat atherosclerosis, reduce side effects and improve the treatment effect and safety.

The invention belongs to the technical field of biological medicines and nano materials, and particularly relates to a composite nano particle for treating atherosclerosis as well as a preparation method and application of the composite nano particle. According to the composite nanoparticle, polydopamine nanoparticles serve as a core carrier, gold nanoparticles and probucol are loaded, and the outermost layer is coated with erythrocyte membrane vesicles. According to the invention, the active oxygen scavenging ability of the polydopamine nanoparticles, the enzyme-like catalytic activity of the gold nanoparticles, the lipid-lowering and anti-inflammatory effects of probucol, and the immune escape and focus targeting functions of the erythrocyte membrane are utilized to generate a synergistically enhanced treatment effect. The composite nanoparticles are good in biocompatibility and high in targeting property, can be efficiently enriched at atherosclerotic plaques, remarkably improve the treatment effect and reduce side effects, and have wide application prospects in preparation of atherosclerotic treatment drugs.