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Medicinal composition for treating angiocardiopathy

A composition and cardiovascular technology, applied in the direction of cardiovascular system diseases, drug combinations, active ingredients of heterocyclic compounds, etc., can solve problems such as differences in probucol absorption rate and absorption amount

Inactive Publication Date: 2009-04-22
北京博时安泰科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

On the other hand, the rate and amount of absorption of probucol varies significantly between individual patients

Method used

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  • Medicinal composition for treating angiocardiopathy
  • Medicinal composition for treating angiocardiopathy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Prescription (per 1000 tablets):

[0024] Atorvastatin Calcium 10g

[0025] Probucol 500g

[0026] Sodium carboxymethyl starch 50g

[0027] Corn starch 3000g

[0028] Magnesium Stearate 300g

[0029] Pass atorvastatin calcium and probuco through a 40-mesh sieve. Thoroughly mix atorvastatin calcium and probucol with cornstarch and carboxymethyl starch sodium according to the prescription amount, mix with magnesium stearate and compress into tablets to obtain the product.

Embodiment 2

[0031] Prescription (per 1000 tablets):

[0032] Atorvastatin Calcium 10g

[0033] Probucol 500g

[0034] Sodium carboxymethyl starch 50g

[0035] Lactose 1000g

[0036] Magnesium Stearate 200g

[0037] Pass atorvastatin calcium and probuco through a 40-mesh sieve. Thoroughly mix atorvastatin calcium, probucol, lactose and carboxymethyl starch sodium according to the prescription amount, mix with magnesium stearate and compress into tablets to obtain the product.

Embodiment 3

[0039] Prescription (per 1000 capsules):

[0040] Atorvastatin Calcium 10g

[0041] Probucol 500g

[0042] Sodium hydroxymethyl starch 40g

[0043] Hydroxypropyl methylcellulose solution (1%) 50g

[0044] Microcrystalline Cellulose 800g

[0045] Magnesium Stearate 200g

[0046] Pass atorvastatin calcium and probu through an 80-mesh sieve. After fully mixing atorvastatin calcium, probucol, microcrystalline cellulose and carboxymethyl starch sodium according to the prescription quantity, the soft material was prepared with the prescription quantity of hydroxypropyl methylcellulose solution, granulated, dried, Sieve through a 18-mesh sieve, mix thoroughly with the prescribed amount of magnesium stearate, and pack into capsules.

[0047] The investigation of the stability of atorvastatin calcium in the composition of the present invention

[0048] Adopting high performance liquid chromatography to detect that the content in the pharmaceutical composition of Examples 1-3 of th...

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Abstract

The invention relates to a medicine composition for treating angiocardiopathy. The composition comprises atorvastatin calcium and probucol with therapy dose and pharmaceutically acceptable carriers or excipients.

Description

technical field [0001] The invention relates to the field of drug therapy, and more specifically relates to a drug composition for treating cardiovascular diseases. Background technique [0002] In my country, cardiovascular and cerebrovascular diseases are the number one cause of death. With the improvement of living standards, people's diet structure changes, activity decreases, cholesterol intake and body mass index increase, all of which are risk factors for cardiovascular and cerebrovascular diseases. The incidence of cardiovascular and cerebrovascular diseases in my country has been increasing year by year in recent years. [0003] Among cardiovascular diseases hypertension, myocardial infarction and angina pectoris are among the most common causes of death in both men and women. In addition to coronary artery disease, cerebrovascular disease and stroke are the most common causes of death. In addition, cardiovascular disease causes significant disability from stroke...

Claims

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Application Information

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IPC IPC(8): A61K31/40A61K31/10A61P9/00
Inventor 颜文革漆新国阚迎昕
Owner 北京博时安泰科技发展有限公司
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