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Chitin nanometer granule for programmable releasing various kinds of medicine, and its prepn. method

A chitosan nanometer and nanoparticle technology, which is applied in the field of medical engineering, can solve the problems of no time lag effect, the microspheres cannot reach the nanometer level, and the programmed release of various drugs cannot be realized, so as to reduce the pain of patients and improve medical treatment. cost, improved utilization, improved drug stability and effectiveness

Inactive Publication Date: 2006-11-29
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its shortcomings are: the formed microspheres cannot reach the nanometer level, and cannot fully reflect the unique release characteristics of the nanosystem; the drug is released from the first time, and there is no time-lag effect; only one drug is loaded, and multiple drugs cannot be realized. procedural release of
The existing single-drug nano-loading system cannot meet the above-mentioned needs. In view of this situation, the present invention prepares chitosan drug-loaded nanoparticles loaded with drugs of different properties, which can not only control and slow release of drugs, but also prolong the life of drugs. It can also realize the programmed release of various drugs according to different symptoms in different periods after surgery

Method used

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  • Chitin nanometer granule for programmable releasing various kinds of medicine, and its prepn. method
  • Chitin nanometer granule for programmable releasing various kinds of medicine, and its prepn. method
  • Chitin nanometer granule for programmable releasing various kinds of medicine, and its prepn. method

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Embodiment 1: the chitosan nanoparticle of the programmed release multiple medicines to be prepared, specific weight percentage is: chitosan 58.52%, hydrophilic medicine 10.53%, lipophilic medicine 5.26%, Tween-800.01%, Sodium tripolyphosphate 10.53%, the preparation process is as follows:

[0036] (1) Preparation of aspirin-chitosan nanoparticles

[0037]Take by weighing 10mg aspirin and concentration be that 2mg / ml chitosan acetic acid solution 25ml phase mix, add 1ml concentration after stirring evenly and be the surfactant Tween-80 of 1wt%, under room temperature magnetic stirring (500r / s), drop 10 ml of 1 mg / ml sodium tripolyphosphate solution was continuously stirred for 1 hour to obtain a solution of chitosan nanoparticles loaded with aspirin. The aspirin-chitosan drug-loaded nanoparticles are obtained by centrifugal separation and freeze-drying.

[0038] figure 1 It is an electron micrograph of the nanoparticle of the present invention (prepared as described ...

Embodiment 2

[0049] Embodiment 2: the chitosan nanoparticle of the programmed release multiple medicines to be prepared, specific weight percent is: chitosan 66.10%, hydrophilic medicine 15.02%, lipophilic medicine 6.29%, Tween-800.03%, Sodium Tripolyphosphate 12.58%. The preparation process is as follows:

[0050] (1) Preparation of aspirin-chitosan nanoparticles

[0051] Get 25mg of aspirin medicine and concentration is that 25ml of chitosan acetic acid solution of 3mg / ml are mixed, after stirring, add 1ml concentration and be the tensio-active agent Tween-80 of 3wt%, under room temperature magnetic stirring (500r / s), drop 10ml of 2mg / ml sodium tripolyphosphate solution was continuously stirred for 1 hour to obtain the aspirin-loaded chitosan nanoparticle solution. The aspirin-chitosan drug-loaded nanoparticles are obtained by centrifugal separation and freeze-drying.

[0052] (2) Preparation of probucol chitosan nanoparticles

[0053] Get the chitosan solution 25ml of 3mg / ml, add 1m...

Embodiment 3

[0058] Embodiment 3: the chitosan nanoparticle of the programmed release multiple medicines to be prepared, specific weight percentage is: chitosan 73.67%, hydrophilic medicine 19.51%, lipophilic medicine 7.31%, Tween-800.06%, Sodium Tripolyphosphate 14.63%. The preparation process is as follows:

[0059] (1) Preparation of aspirin-chitosan nanoparticles

[0060] Get 40mg of aspirin medicine and concentration is that 25ml of chitosan acetic acid solution of 4mg / ml are mixed, add 1ml concentration after stirring evenly and be the tensio-active agent Tween-80 of 6wt%, under room temperature magnetic stirring (500r / s), add dropwise 10ml of 2mg / ml sodium tripolyphosphate solution was continuously stirred for 1 hour to obtain the aspirin-loaded chitosan nanoparticle solution. The aspirin-chitosan drug-loaded nanoparticles are obtained by centrifugal separation and freeze-drying.

[0061] (2) Preparation of probucol chitosan nanoparticles

[0062] Get the chitosan solution 25ml ...

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Abstract

A chitosan nanoparticle able to sequentially release more medicines is proportionally prepared from chitosan, hydrophilic medicine (aspirin), lipophilic medicine (probucol), tween-80 and sodium tripolyphosphate by ion exchange method and microemulsifying method. It features that the aspirin is first released for 24 hr and the probucol is then released for 5 days.

Description

technical field [0001] The invention relates to a preparation in the technical field of medical engineering and a preparation method thereof, in particular to a chitosan nanoparticle for programmed release of various drugs and a preparation method thereof. Background technique [0002] The classification of chitosan nanospheres mainly includes the following types: chitosan nanospheres prepared by covalent cross-linking method, chitosan nanospheres prepared by desolventization method, chitosan nanospheres prepared by ion cross-linking method and shell Polysaccharides are blended with polyanionic substances to form nanospheres. Among them, ionically cross-linked chitosan nanospheres have many attractive properties: these features make it a promising macromolecular drug carrier. These characteristics include: 1) the synthesis conditions of chitosan nanospheres are mild; 2) the spheres are very uniform and can be adjusted in size (10-200nm) and have a positive surface that can ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/36A61K47/04A61K47/06A61K45/00
Inventor 万锕俊张悦粤李慧丽
Owner SHANGHAI JIAO TONG UNIV
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