9 results about "Macromolecular drug" patented technology

The application discloses a swallowable drug device combination device for promoting intestinal absorption of macromolecular drugs, and belongs to the technical field of drug delivery and medical devices, and the structure comprises an intestinal built-in vibration component and an external alternating magnetic field driving component; the intestinal built-in vibration component comprises a soft magnetic layer and an adhesive hydrogel layer, the soft magnetic layer is prepared by magnetizing after curing of an elastomer material doped with magnetic particles, and the adhesive hydrogel layer is a sodium alginate-acrylamide double-network hydrogel loaded with macromolecular drugs; the external alternating magnetic field driving component comprises a power module, a current driving module, an electromagnetic module, a control module and an interactive terminal; in the working state, the alternating magnetic field generated by the external alternating magnetic field driving component penetrates the body surface tissue and acts on the soft magnetic layer of the intestinal built-in vibration component, so that mechanical vibration is generated to exert physical stimulation on the local tissue in the intestine. The device can accelerate the release rate of macromolecular drugs and enhance the absorption efficiency of the macromolecular drugs in the intestine.

This invention belongs to the field of biomedical technology, specifically relating to a biodegradable hyaluronic acid gel microsphere with synergistic effects of physical embolization and macromolecular drug loading, its preparation method, and its application in arterial chemoembolization. This embolic microsphere can load not only small molecule drugs but also ADC drugs, achieving long-term release, and is completely degradable, meeting the needs of long-term clinical application.

The application belongs to the technical field of hydrogel, and particularly relates to a magnetic drug-loaded hydrogel microsphere, a preparation method and application thereof. The magnetic drug-loaded hydrogel microsphere comprises the following raw materials in mass parts: 1-40 parts of hydrogel crosslinking precursor, 2-30 parts of initiator, 0.1-1 part of magnetic nanoparticle loaded with small molecule drug, and 0-1 part of macromolecular drug. The application has the following beneficial effects: the magnetic drug-loaded hydrogel microsphere has injectability and magnetic responsiveness, can simultaneously load bioactive macromolecules and small molecules, and can realize double release of anti-inflammatory small molecules and nerve growth promoting macromolecules in the magnetic drug-loaded hydrogel microsphere, so as to synergistically reduce the harmfulness of spinal cord injury; the magnetic nanoparticle can realize flexible loading of small molecule anti-inflammatory drugs through surface functionalization; and the magnetic nanoparticle can also be used as a magnetic response clue to realize magnetic intervention on the spinal cord injury tissue in cooperation with an external static magnetic field.

The application discloses a biological macromolecular drug for tumor treatment, which has tissue protein adhesion, can continuously improve the oxidative stress environment of a tumor site by prolonging the time at the tumor site, can inhibit tumor growth by tumor microenvironment regulation, can also be used as an auxiliary therapeutic agent to enhance the curative effect of other tumor treatments, and has a good clinical transformation prospect.

This invention discloses a method for preparing biomimetic vesicles capable of targeted drug delivery for tumor treatment or tissue regeneration, relating to the field of nanomedicine delivery, particularly suitable for the delivery of macromolecular and protein drugs. The method includes: S1, mixing tetraethyl orthosilicate, water, and anhydrous ethanol in a volume ratio, adjusting the pH to acidic with hydrochloric acid and hydrolyzing; diluting the hydrolysate and adjusting the pH to weakly alkaline with ammonia; adding a therapeutic agent and gel aging at low temperature to form a hydrous gel block; diluting the gel block, followed by ultrasonic disruption and filtration to obtain porous silica drug-loaded nanoparticles with a particle size between 10-300 nm; S2, adding dopamine hydrochloride to the drug-loaded core suspension and allowing it to react statically at low temperature in an alkaline environment provided by Tris-HCl buffer, causing polydopamine to polymerize on the surface of the drug-loaded core to form a capsule shell. The "core-shell-membrane" three-layer biomimetic vesicles constructed by this invention synergistically achieve multiple advantages such as high drug loading, long-lasting circulation, precise targeting, and potential stimulus-responsive drug release.

This application relates to the field of macromolecular drug carrier technology, and more particularly to a nanocarrier, its preparation method, and its application. The nanocarrier is used to carry FMF-06-098-1. The preparation method includes: mixing ferric acetylacetone, oleyl phosphate, 1,2-hexadecanediol, and anhydrous diphenyl ether under an inert atmosphere to obtain a precursor solution; crystallizing the precursor solution to obtain a nanocube stock solution; performing a first hydrophobic bonding with excess oleic acid on the nanocube stock solution, followed by curing with polycaprolactone and polyvinyl alcohol, and finally performing a second hydrophobic bonding with an oleic acid solution to obtain magnetic drug-loaded nanoparticles; homogenizing the cationic cellulose dispersion, the target drug, and the magnetic drug-loaded nanoparticles to obtain a pre-gel mixture; gelling the pre-gel mixture in a static uniform magnetic field and freeze-drying to obtain the nanocarrier. This preparation method can improve the dispersibility of macromolecular inhibitors.

This invention discloses a class of dendritic lipopeptide molecules that promote the oral absorption of macromolecular drugs, their preparation method, and applications. The dendritic lipopeptide molecules are formed by combining a hydrophilic head and a hydrophobic tail. The hydrophilic head consists of lysine and glutamic acid linked by amide bonds, while the hydrophobic tail is composed of organic carbon chains or fluorinated chains. The oral absorption enhancer used in this invention exhibits amphoteric characteristics, possessing excellent anti-protein adsorption capabilities, superior mucus penetration and small intestinal permeability, and good biocompatibility due to its amino acid element construction. The oral absorption enhancer used in this invention can cross multiple barriers, including the mucus layer and intestinal epithelial cells, without opening tight junctions, facilitating efficient and safe oral encapsulation and delivery of proteins.

The application provides a preparation method of a multi-level hole UiO-66(SO3H)2 material, which is prepared by a solvent thermal method assisted by double regulators and combined with in-situ oxidation and acidification, so that the effective pore diameter of the material is expanded while the internal active sites of the material are modified, rich mesoporous transmission channels (mesoporous pore diameters are concentrated in 3-10nm) are constructed, and the problem of mass transfer limitation of macromolecular drugs in the material is solved; in combination with the hydrophilic and negatively charged sulfonic acid groups (-SO3H) introduced by post-modification, strong electrostatic attraction and hydrogen bond effect between the material and fluoroquinolone drug molecules are generated. Strong synergy between physical channels and chemical target sites makes the material exhibit superfast adsorption rate far beyond conventional microporous materials, and solves the problem that trace antibiotics cannot be deeply removed in the prior art.

The utility model discloses a scroll spring assembly, including spring seat, the sleeve is rotationally arranged in spring seat, the inner wall of spring seat and the outer wall of sleeve are set up scroll spring, and the inner end of scroll spring is connected with sleeve, and the outer circumference of sleeve is fixedly set up clamping block, and the inner end of scroll spring is set up and is connected in the clamping hole, and the curvature of the inner end of scroll spring is not less than the curvature of the outer circumference of sleeve, the inner wall of spring seat is fixedly set up and is connected, and the outer end of scroll spring is fixedly set up and is connected, and the curvature of the outer end of scroll spring is not greater than the curvature of spring seat inner wall, the utility model discloses the scroll spring assembly, when carrying out injection, scroll spring assembly provides greater torque, and provides greater thrust for injection, and the demand of solving injection viscosity big drug and macromolecular drug is solved.