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Biodegradable calcium sulfate/gelatin composite micro needle array patch and preparation method thereof

A microneedle array and calcium sulfate technology, which is applied in the direction of microneedles, needles, and medical devices, can solve the problems of unfavorable skin release of drugs and affecting drug delivery efficiency, and achieve simple preparation steps, convenient operation, and mild reaction conditions. Effect

Active Publication Date: 2016-08-24
ZHEJIANG SCI-TECH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the bioceramic material itself has a certain brittleness, which is not conducive to piercing the skin to release drugs, which greatly affects the drug delivery efficiency.

Method used

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  • Biodegradable calcium sulfate/gelatin composite micro needle array patch and preparation method thereof
  • Biodegradable calcium sulfate/gelatin composite micro needle array patch and preparation method thereof
  • Biodegradable calcium sulfate/gelatin composite micro needle array patch and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] figure 1 Schematic diagram of the preparation process for the biodegradable calcium sulfate / gelatin composite microneedle array patch. The specific preparation steps are as follows:

[0033] (1) After mixing the liquid polydimethylsiloxane prepolymer and the curing agent at a mass ratio of 10:1, pour it on the microneedle silicon substrate, first vacuumize to remove air bubbles, and then return to normal atmospheric pressure, in Heating at 90°C for 2 hours, demoulding to obtain a microneedle template;

[0034] (2) Dissolve 3.397g of calcium lactate and 1.919g of potassium sulfate in 20mL of 15% aqueous gelatin solution, heat and stir in a water bath at 38°C, and wait for the water to evaporate to about 8mL to obtain a paste mixture;

[0035] (3) After adding 100 μL of 2.5% glutaraldehyde to the paste mixture, stir it evenly and pour it into the microneedle template prepared in step (1), centrifuge at 6000 rpm for 10 minutes, and wait until the paste mixture is filled ...

Embodiment 2

[0040] (1) The preparation of the microneedle template is the same as in Example 1;

[0041](2) Dissolve 6.588g of calcium gluconate and 2.559g of potassium sulfate in 10mL of 12.5% ​​aqueous gelatin solution, heat in a water bath at 38°C and stir thoroughly until the water evaporates to about 10mL to obtain a paste mixture ;

[0042] (3) After adding 150 μL of 1.25% glutaraldehyde and 2 mg of insulin to the paste mixture, stir it evenly and pour it onto the microneedle template prepared in step (1), centrifuge at 6000 rpm for 15 minutes, and wait for the paste to form After the mixture fills the mold cavity, remove excess pasty mixture from the formwork surface;

[0043] (4) At room temperature, add dropwise a mixed solution consisting of 4 mL of 10% gelatin and 0.5 mL of 1.5% genipin above the mold cavity;

[0044] (5) After the mixed solution completely covers the surface of the mold cavity, place the microneedle template in a ventilated place to dry naturally. After demo...

Embodiment 3

[0046] (1) The preparation of the microneedle template is the same as in Example 1;

[0047] (2) Dissolve 2.449g of calcium chloride and 3.132g of sodium sulfate in 10mL of 20% aqueous gelatin solution, heat in a water bath at 38°C and stir thoroughly until the water evaporates to about 6mL to obtain a paste mixture ;

[0048] (3) After adding 1.5 mL of carbodiimide with a concentration of 1.5% and 3 mg of heparin into the paste mixture, stir it evenly and pour it into the microneedle template prepared in step (1), centrifuge at 7000 rpm for 15 min, and wait for After the pasty mixture fills the mold cavity, remove excess pasty mixture on the surface of the template;

[0049] (4) At room temperature, drop 5 mL of a mixed solution consisting of 15% gelatin and 240 μL of 1.25% glutaraldehyde above the mold cavity;

[0050] (5) After the mixed solution completely covered the surface of the mold cavity, the microneedle template was placed in a ventilated place to air dry natural...

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Abstract

The invention belongs to the technical field of micro needle transdermal delivery equipment, and particularly relates to a biodegradable calcium sulfate / gelatin composite micro needle array patch and a preparation method thereof. The composite micro needle array patch comprises a cross-linked gelatin flexible patch and biodegradable calcium sulfate / gelatin composite micro needles; the cross-linked gelatin flexible patch is prepared from gelatin and a cross-linking stabilizer; the biodegradable calcium sulfate / gelatin composite micro needles are prepared from calcium sulfate, the gelatin and the cross-linking stabilizer; the biodegradable calcium sulfate / gelatin composite micro needles are arranged on the cross-linked gelatin flexible patch in an array mode; solid protein macromolecular drugs are embedded in the biodegradable calcium sulfate / gelatin composite micro needles. The biodegradable calcium sulfate / gelatin composite micro needle array patch disclosed by the invention has good biocompatibility, is safe and pollution-free, is simple in preparation process, is rapid to form, is suitable for mass production, and can be widely applied to the field of transdermal delivery of the protein macromolecular drugs.

Description

technical field [0001] The invention belongs to the technical field of microneedle transdermal drug delivery equipment, and in particular relates to a biodegradable calcium sulfate / gelatin composite microneedle array patch and a preparation method thereof. Background technique [0002] The traditional injection uses a syringe to inject the drug into the body. After the drug is injected, it can quickly reach the blood and take effect, but it is painful when injected, and the injection site sometimes causes local adverse reactions. In addition, if the drug is misused, it may cause irreparable consequences. . Since Henry first used solid silicon microneedle array chips for drug transdermal drug delivery research in 1998, the research on microneedle transdermal drug delivery systems has made great progress in the past two decades and is expected to replace the traditional drug delivery system. way of injection. Microneedle transdermal drug delivery is composed of tens to hundr...

Claims

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Application Information

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IPC IPC(8): A61M37/00C08L89/00C08K3/30C08K5/07C08K5/29C08K5/1545
CPCA61M37/0015C08K3/30C08K5/07C08K5/1545C08K5/29A61M2037/0053C08K2003/3045C08L2201/06C08L89/00
Inventor 江国华余伟江孔祥东姚菊明童再再
Owner ZHEJIANG SCI-TECH UNIV
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