33 results about "Micro-needle" patented technology

The invention discloses microminiature needle body high-speed visual screening equipment and a screening method thereof, and belongs to the technical field of industrial automatic detection and sorting. The equipment comprises an equipment frame, a feeding module, a visual identification module, a grabbing module, a control module and a material receiving module. The feeding module is used for conveying to-be-screened needle bodies. The visual identification module performs image acquisition and model identification on the needle body; the grabbing module is provided with a plurality of grabbing clamping jaws, can move in the horizontal direction and the vertical direction under the driving of the control module, and grabs a plurality of needle bodies of the same model at the same time at a time. The material receiving module comprises a plurality of material receiving boxes and a transposition driving mechanism for driving the material receiving boxes to move so as to align the target material receiving box to the grabbing module. The equipment disclosed by the invention can be widely applied to high-efficiency sorting of micro-miniature needle bodies with the diameters ranging from 0.3 mm to 3mm and the lengths ranging from 3mm to 77mm, has high precision, high speed and high reliability, and is suitable for large-scale production and multi-variety and small-batch production requirements.

Disclosed is a needle tip structure for a handpiece having an NFC function. The needle tip includes a body mounted at the front end of a handpiece, a first substrate fixed within the body and connected to a plurality of RF supply terminals of the handpiece, a second substrate on which a plurality of micro needles is mounted and movably installed within the body, a holder coupled to a driving shaft of the handpiece through the first substrate and configured to support the second substrate, and a pair of connection pins connected to the second substrate and the first substrate. An NFC chip capable of short-distance wireless communication with an external NFC terminal is installed in the first substrate.

The invention discloses a solder and a packaging structure. The solder comprises: a base material; the repairing capsule is mixed in the base material and internally comprises a repairing material; the microneedle is mixed in the base material, the microneedle is a shape memory alloy, and the microneedle deforms to puncture at least part of the repair capsule, so that the repair material flows out of the punctured repair capsule and fills the space defect of the base material; or / and the melting point of the repairing material is less than the phase transition temperature of the shape memory alloy. The self-repairing of the solder can be realized through the matching of the repairing capsule and the microneedle, so that the solder has longer service life and higher reliability.

The application provides a physiotherapy instrument, the physiotherapy instrument comprises a host, a micro needle head and a protective frame, the host comprises a handle shell and a mounting seat, the mounting seat is fixed at one end of the handle shell, the micro needle head is provided with a bearing part for mounting a micro needle part, and the micro needle part can be fixed on the bearing part. The bearing part protrudes out of the mounting base in the direction away from the handle shell, the protection frame is detachably fixed to the mounting base, the micro needle head is detachably connected with the main machine, and when the micro needle head needs to be detached, the protection frame can be detached from the mounting base firstly, so that the bearing part and the mounting base are both exposed, and then the micro needle head can be detached. The protection frame is prevented from blocking the hand or a tool from getting close to the bearing part, the bearing part protrudes out of the installation base, a user can directly hold the protruding part of the bearing part to apply force so as to detach the micro needle head, and the micro needle head can be installed, fixed or detached more conveniently.

The utility model relates to the technical field of microneedles, and discloses a telescopic structure device of microneedle needles, which comprises a housing and a needle seat, a plurality of needles are arranged on the needle seat, a rotating cylinder is rotatably inserted in the housing, a liquid storage cavity with the same inner diameter as the rotating cylinder is arranged on the needle seat, the liquid storage cavity is inserted in the rotating cylinder, and the rotating cylinder is provided with a liquid outlet. A plug pin is fixedly arranged on the outer wall of the liquid storage cavity, a spiral sliding groove is formed in the barrel wall of the rotary barrel, the plug pin is inserted into the sliding groove, a cover plate is arranged at the top of the rotary barrel, a plurality of positioning tooth grooves are formed in the inner wall of the cover plate in a circumferential array mode, and a positioning assembly used for fixing the position of a needle seat is arranged on the housing. The pillow is telescopic, different pillow lengths can be adjusted, different use requirements are met, meanwhile, the needle head is stored in a contracted mode in the unused state and does not make contact with the outside, and the use safety is higher.

The invention discloses a processing method of a nano microneedle, which relates to the technical field of nano microneedles and comprises the following steps: cleaning the surface of a monocrystalline silicon or gold wafer, coating photoresist on the surface of the monocrystalline silicon or gold wafer, drying, transferring a microneedle array pattern to a photoresist layer through a photoetching process, putting the wafer into a vacuum reaction cavity, introducing reaction gas, and carrying out vacuum reaction on the wafer and the photoresist layer to obtain the nano microneedle. The processing method comprises the following steps: applying radio frequency power to generate plasma, carrying out anisotropic etching on a wafer, forming a microneedle cylinder, removing residual photoresist and cleaning to obtain a microneedle array, applying UV glue to a preset position of a plastic part, mounting the microneedle array to the glue dispensing position of the plastic part, and then carrying out UV irradiation on a mounted product to cure the UV glue. The size, the shape and the position of the microneedle and the nanostructure can be controlled by accurately designing a mask and etching parameters, the size range is from dozens of micrometers to hundreds of micrometers, the shape is from a cylinder to a cone, and the design freedom degree is large.

The invention provides a high-air-tightness flexible graphite polar plate and a preparation method thereof. The preparation method comprises the following steps: (1) carrying out compression molding on an expanded graphite prefabricated plate to form a graphite blank polar plate; (2) punching a micro needle hole in the graphite blank pole plate by adopting a micro needle; (3) carrying out dipping treatment on the graphite blank polar plate with the micro pinholes obtained in the step (2) in dipping glue to obtain a dipped polar plate; and (4) cleaning, curing, drying and leveling the pole plate impregnated in the step (3) to obtain the high-air-tightness flexible graphite pole plate. According to the method disclosed by the invention, a method for punching the micro holes in the surface of the molded graphite blank polar plate is innovatively adopted, so that a part of pores in the molded graphite blank polar plate are broken. The punched micro holes enable gas in pores existing in the prefabricated plate to be extracted more easily, and the pole plate is filled with the impregnating adhesive more easily, so that the impregnating difficulty of the impregnating adhesive is reduced, and the air permeability is improved.

The invention discloses a fluorescent navigation lacrimal ductule broken end recognition and anastomosis device, and relates to the technical field of ophthalmology medical instruments, the recognition and anastomosis device comprises a microscopic needle holder, one side of the microscopic needle holder is provided with a pair of connecting blocks, one side of the pair of connecting blocks is provided with a detachable connecting mechanism and a detachable matching mechanism, and the other side of the pair of connecting blocks is provided with a fluorescent navigation device. The embedded groove is formed in the lacrimal passage probe, and the fluorescent rod capable of emitting infrared fluorescence is arranged in the groove, so that when the fracture part of the lacrimal ductule needs to be observed, the lacrimal passage probe capable of emitting infrared fluorescence is inserted into the lacrimal ductule, and the position of the fracture end of the lacrimal ductule is judged; the microscopic needle holder is convenient for a follow-up doctor to hold the microscopic needle holder to carry out anastomosis operation on the lacrimal ductule, the broken end can be quickly and accurately aligned and sutured, the success rate of high broken end identification and the operation efficiency are improved, the operation difficulty and excessive dependence on doctor experience are reduced, and the postoperative anastomosis patency rate and the life quality of a patient are improved.

The utility model discloses a thin-layer sample application auxiliary device for drug inspection, and relates to the technical field of drug inspection. The sample application mechanism comprises a lifting disc, a rotating rod is rotationally arranged at the bottom end of the lifting disc, a mounting frame is fixedly arranged at the bottom end of the rotating rod, sample application assemblies distributed in an array mode are mounted on the outer side of the mounting frame, each sample application assembly comprises a micro needle head, each sample application assembly comprises a fixing rod, and a fixing disc is fixedly arranged at the bottom end of each fixing rod; a positioning assembly is installed at the bottom end of the fixing disc, a ball is fixedly arranged at the top end of the fixing rod, and a slope is fixedly arranged at the bottom end of the lifting disc. According to the utility model, the mounting frame, the rotating rod, the plurality of sample application components and other structures are matched with one another, so that automatic switching and accurate positioning of multiple pipes can be realized, a plurality of samples or different solvents can be accurately treated simultaneously, the sample application speed and consistency are greatly improved, the working efficiency is improved, human errors are reduced, and the production cost is reduced. Therefore, the accuracy and the reliability of medicine inspection are ensured.

The high-precision machining technology comprises the following steps that solid raw materials are selected for pretreatment, cutting is conducted after treatment to obtain a micro-needle profile, the micro-needle profile is subjected to accurate grinding, specifically, burrs and uneven positions are removed, the head of the micro-needle profile is ground, and an inclination angle with the axial surface is formed; the method comprises the following steps: polishing an obtained micro-needle profile, preparing a surface coating composition, coating the polished micro-needle profile with the composition, measuring the inclination angle of an inclined surface after coating, trimming the inclination angle, carrying out secondary polishing to obtain a micro-needle head, cleaning and disinfecting the obtained micro-needle head, carrying out quality detection, and packaging and delivering the micro-needle head from a warehouse. Compared with the prior art, the high-precision machining process for the micro needle head for injection has the advantages that operation and use are convenient, and the machining precision is guaranteed.

The present invention relates to the technical field of medical devices, and provides a force-sensing microinstrument, which includes a housing and a drug injection assembly. The housing includes a drug injection needle tube, a first optical fiber, and a second optical fiber; a bent needle tip is provided at the distal end of the drug injection needle tube; the first optical fiber and the second optical fiber are distributed along the length direction of the drug injection needle tube on the outer periphery of the drug injection needle tube and are encapsulated in the housing; the first optical fiber and the second optical fiber are Bragg optical fibers, both are provided with grating regions, and at least one of the two is provided with a plurality of the grating regions at intervals, and the grating regions are used to sense the radial force received by the drug injection needle tube. This force-sensing microinstrument can detect the puncture force of the drug injection needle tube on blood vessels only through two Bragg optical fibers, reducing the outer diameter of the force-sensing micro needle, enabling it to fit a smaller-sized trocar, thereby reducing the damage to the sclera during retinal vein injection operations and reducing the risks of bleeding, hyperplasia of the tissue around the incision, and retinal traction.

The invention provides a hair growing device for caring and growing hair based on exosomes, and relates to the technical field of caring and hair growing, the hair growing device comprises a bearing support, a bearing cylinder frame, a conveying pump body, a bearing joint, a driving sleeve and a bearing support cylinder; a rotating sliding groove is formed in the top of the bearing support. The bearing cylinder frame is fixedly mounted on the inner side of the mounting open groove; the conveying pump body is fixedly mounted at one end of the inner side of the bearing barrel frame; the bearing joint is fixedly mounted at one end of the inner side of the bearing barrel frame; a mounting lantern ring is fixedly arranged at one end of the inner side of the driving sleeve; a mounting support ring is fixedly arranged on the inner side of the bearing support cylinder, and the bearing support cylinder rotationally sleeves the outer side of one end of the bearing cylinder frame through the mounting support ring; after the bearing supporting cylinder is driven by the telescopic supporting rod to move, the micro needle head is pricked into the scalp to perform reciprocating minimally invasive dot matrix treatment on the surface of the head of a user; the problems that exosome maintenance is different from simple coating administration, and a device special for cell exosome hair care and hair growth needs to be designed and prepared are solved.

1. The name of the design product: electric micro needle head (skin pen). 2. The use of the design product: for electric micro needle head. 3. The design points of the design product: in shape. 4. The picture or photo that best shows the design points: perspective view.

Disclosed is an invasive high-frequency treatment device. The invasive high-frequency treatment device includes multiple micro needles including a first micro needle and a second micro needle, an elevation unit configured to raise the micro needle, and a control circuit configured to control the elevation unit. The control circuit determines a procedure zero point of the elevation unit corresponding to the multiple micro needles in an initialization step of the invasive high-frequency treatment device, and controls the elevation unit to rise at a predetermined height from the procedure zero point in a procedure step of the invasive high-frequency treatment device. Accordingly, it is possible to make consistent the location of the micro needles prior to a procedure regardless of conditions for a design, an assembly, and use.

The utility model discloses a miniature roller pin which comprises a handle, one end of the handle is fixedly connected with a roller carrier, two sides of the roller carrier are respectively and rotatably connected with a plug screw in a sleeved mode, the opposite ends of the plug screws are respectively connected with a fixing cover through a thread structure, and the fixing covers are in interference connection with two ends of a roller. The rolling wheel is rotationally arranged in the rolling wheel frame, a plurality of clamping strips are clamped on the peripheral side of the outer wall of the rolling wheel in a sliding mode, a plurality of rolling needles are fixedly connected to one end face of each clamping strip, a positioning groove is formed in the middle of the other end face of each clamping strip in an inward concave mode, and a limiting assembly is clamped in each positioning groove and arranged on the corresponding rolling wheel. The rolling wheel can be integrally taken down by taking down the plug screw, and the fixing covers in interference connection with the two ends of the rolling wheel are taken out respectively, so that the clamping strips can be taken down respectively, the rolling needle can be replaced conveniently, and the requirements of different lengths are met.

The application discloses an embedded manifold microchannel LTCC substrate with added micro needle fins, which comprises a top cover layer, a middle microchannel layer, a bottom substrate layer and an external driving assembly. The top cover layer is provided with a radio frequency device unit. The middle microchannel layer is provided with a main path and a bypass manifold microchannel. A plurality of shunt micro needle fins are arranged at the input section of the main path manifold microchannel. A plurality of turbulence micro needle fins are arranged at the bypass manifold microchannel. The bottom substrate layer is provided with an inlet / outlet port. The external driving assembly comprises a controller, a micro tube and a micro pump. During operation, the cooling medium is transmitted through the micro tube, flows through the main path manifold microchannel of the middle microchannel layer, is distributed to the bypass manifold microchannel through the shunt micro needle fins, is fully mixed under the action of the turbulence micro needle fins, carries away the heat generated by the high-power radio frequency device and is transported to the external environment. The application realizes the organic fusion of the LTCC substrate and the heat dissipation technology and strengthens the efficient cooling of the high heat flux density radio frequency device.

The present invention discloses a multi-layer stacked structure for a high-power radio frequency chip with high-efficiency heat dissipation and a preparation method thereof; the structure sequentially includes a base layer structure, a first active device layer, a first metal interconnection layer, a heat dissipation buffer layer, a second active device layer, a second metal interconnection layer, and a top-layer heat dissipation structure from bottom to top; wherein, the heat dissipation buffer layer adopts a microchannel structure filled with a phase change material to achieve active temperature regulation; the top-layer heat dissipation structure adopts a graphene-micro needle array composite design and has a switchable heat dissipation mode; this structure significantly improves the heat dissipation efficiency of the high-power radio frequency chip, improves the device reliability, reduces the influence of the heat dissipation structure on the radio frequency performance, and is applicable to high-frequency high-power application scenarios such as 5G communication.

The utility model discloses a microneedle head and a leading-in microneedle roller device, and relates to the technical field of microneedle treatment, the leading-in microneedle roller device comprises a piercing microneedle, the upper end of the piercing microneedle is fixedly connected with a permanent magnet push block, the leading-in microneedle roller device comprises the microneedle head and further comprises a needle seat center cylinder, a plurality of needle guide cylinders are fixedly connected to the downward position of the outer wall of the needle base center cylinder at equal intervals, needle heads of a plurality of piercing micro needles face downwards and are movably inserted into the needle guide cylinders in a one-to-one correspondence mode, and the upper ends of the piercing micro needles penetrate through the needle base center cylinder and then are fixedly connected with a permanent magnet push block. Electromagnets are fixedly connected to the positions, corresponding to the permanent magnet push blocks, of the inner wall of the needle base center cylinder, the needle guide cylinder is kept vertically and downwards arranged, the electromagnets are powered on and off at a time, one-time needling is rapidly executed, the needling path and the pulling-out path of the needle head of the needling microneedle are the same, the needling wound range of the needling microneedle can be reduced, and the needling efficiency is improved. The healing time of a patient is shortened while the treatment effect is ensured.

The application discloses a kind of based on hydrogen combustion and micro needle electrode ignition ultra-high energy density micro engine device and preparation method thereof, belong to micro electro mechanical system and micro energy technology field.The device mainly includes top cylinder shell, bottom cylinder shell, piston, top plug-in unit and bottom plug-in unit.It is in that a pair of opposite micro needle electrode in micro combustion chamber ignites pre-mixed hydrogen / oxygen, generates high-temperature high-pressure gas to push piston to carry out two-stroke reciprocating motion, to convert chemical energy directly into mechanical energy.The device adopts unique combustion chamber flow channel design, combined with the flow divider on piston, effectively optimizes scavenging process, reduces fuel short circuit, improves gas exchange efficiency.

The utility model discloses a single cell separation device based on a single cell sequencing technology, which relates to the technical field of single cell separation devices and comprises an operation table, a first protective cover is mounted on one side of the top of the operation table, and a second protective cover is mounted on the other side of the top of the operation table. According to the utility model, through the arrangement of the microscope, the micromanipulation instrument, the dilution cup and the like, large microorganism individuals extracted by the capillary tube can be separated under the action of the microscope, and a single microorganism cell can be picked by taking a microneedle, a hook, a ring and the like from the drawer under the action of the micromanipulation instrument, so that the purpose of separation is achieved; a solution with microorganisms can be diluted through the dilution cup to prepare small liquid drops, and the liquid drops only containing one cell are observed and separated through a microscope, so that the separation purpose is achieved, and the device is high in functionality and rich in unicellular organism separation means.

The utility model relates to the technical field of medical instruments, and provides a chest drainage device with an analgesic effect, which comprises a first tube body and a second tube body, a second tube body; the analgesia pump is connected with the near end of the second tube body and is used for conveying analgesic medicine into the second tube body; the releaser is arranged at the far end of the second tube body and is used for being in contact with the pleura; the releaser comprises a medicine storage cavity and a microneedle, the medicine storage cavity is communicated with the second tube body, the microneedle is arranged on the medicine storage cavity, and micropores are formed in the surface of the microneedle. According to the chest drainage device, the first tube body is used for discharging hydrops, the second tube body is used for conveying pain relieving medicine, the releaser is arranged at the far end of the second tube body, the pain relieving medicine in the medicine storage cavity is automatically controlled or continuously released to the pleura at a constant speed through the microneedle according to the pain degree of a patient, and the pain relieving medicine is released to the pleura while the chest is drained. The pain of the patient is reduced, and the treatment and rehabilitation of the patient are facilitated.

The invention discloses a radio frequency microneedle instrument, and relates to the field of skin beauty, the radio frequency microneedle instrument comprises a main machine box body, a radio frequency microneedle main control board, a radio frequency power supply and a negative pressure gas circuit assembly, an accessory installation fixing frame is installed in the main machine box body, and the radio frequency microneedle main control board, the radio frequency power supply and the negative pressure gas circuit assembly are all installed on the accessory installation fixing frame; a 48V adjustable power supply, a 12V switching power supply and a lithium battery are further installed on the accessory installation fixing frame, the negative pressure air path assembly is composed of an air pump and an electromagnetic valve, the exhaust end of the air pump is connected with the valve inlet end of the electromagnetic valve, and an air inlet of the air pump is connected with an internal filter and an external filter through a multi-way air pipe connector. The device has the advantages that the peristaltic effect is achieved, compression and pain caused by negative pressure adsorption are relieved, turn-off loss is greatly reduced, the frequency is high, the instantaneous peak power is high, the action time is short, pain is relieved, and the treatment effect is obvious.

The application discloses a wave micro-channel radiator with a micro needle fin array, which comprises a heat-conducting bottom plate and a heat-conducting cover plate, at least two vertical fins are fixedly connected to the upper portion of the heat-conducting bottom plate, the top of the fin is fixedly connected with the heat-conducting cover plate, two adjacent fins and the heat-conducting bottom plate and the heat-conducting cover plate connected therewith form an independent micro-channel heat transfer unit, and the two ends of the micro-channel heat transfer unit are respectively a working medium outlet and a working medium inlet; the micro-channel heat transfer unit comprises a micro needle fin array and a wave channel; when the micro needle fin array is fixedly arranged on the upper surface of the heat-conducting bottom plate and the lower surface of the heat-conducting cover plate, the opposite surfaces of the two adjacent fins are both in a wave shape, so that the wave channel is formed between the fins and the heat-conducting bottom plate and the heat-conducting cover plate; when the micro needle fin array is fixedly arranged on the side surface of the fin, the upper end surface of the heat-conducting bottom plate and the lower end surface of the heat-conducting cover plate are both provided with wave-shaped grooves, so that the wave channel is formed between the fins and the heat-conducting bottom plate and the heat-conducting cover plate, the heat dissipation efficiency is improved, and the thermal resistance and the flow resistance are reduced.

The utility model belongs to test fixture technical field especially relates to a split type bullet micro needle module and test fixture. The both sides of core needle plate are established with first needle groove group and second needle groove group respectively, the first side edge needle plate and the second side edge needle plate respectively located the both sides of core needle plate, the side of first side edge needle plate is established with the third needle groove group corresponding with first needle groove group, the side of second side edge needle plate is established with the fourth needle groove group corresponding with second needle groove group, the first needle group and the second needle group are formed by a plurality of bullet micro needles, the part of bullet micro needle of first needle group is installed in first needle groove group, and a part is installed in third needle groove group, the part of bullet micro needle of second needle group is installed in second needle groove group, and a part is installed in fourth needle groove group. The utility model discloses a split type needle plate structure, disperses needle groove processing load, promotes needle plate deformation resistance, has the advantages such as convenient processing, high yield, low manufacturing cost.

The utility model discloses a micro needle valve high-pressure common-rail oil injector, which can greatly reduce the weight and the motion inertia of a needle valve through an optimized micro needle valve and a hydraulic device control chamber sinking to the deep part of a fuel oil cavity in an oil nozzle. By means of the technical scheme, the weight of the needle valve can be smaller than 0.5 g, compared with a traditional technology, the length of the needle valve is greatly shortened, the diameter can be correspondingly reduced, and the weight is reduced by more than 85%. Even, in the embodiment of the scheme, the length of the needle valve is only 9.5 mm, the diameter of the head is 1.6 mm, the weight is only about 0.15 g, and compared with a traditional technology, the weight is reduced by about 95%. Obviously, by greatly reducing the weight of the needle valve, the response speed of fuel injection opening and closing control of the fuel injector is greatly increased, the performance of the fuel injector is more excellent, the structure is simple, and the cost is low.

The utility model relates to the technical field of micro-needle modules, and provides a floating micro-needle module of an FPC, which comprises a fixed base and a movable matching seat, the movable matching seat comprises a micro-needle plate seat body and a lower pressing plate seat body, the micro-needle plate seat body is located between the lower pressing plate seat body and the fixed base, and a plurality of first floating elastic pieces are arranged between the micro-needle plate seat body and the lower pressing plate seat body. A plurality of second floating elastic pieces are arranged between the micro-needle plate seat body and the fixed base, a limiting structure is arranged between the movable matching seat and the fixed base and comprises a plurality of limiting holes and a plurality of limiting columns, the limiting holes are formed in the fixed base, and the limiting columns are fixedly connected with the micro-needle plate seat body and located in the limiting holes in a one-to-one correspondence mode; the longitudinal section of each limiting column is of an isosceles trapezoid structure, and the upper bottom of each limiting column is wider than the lower bottom of the limiting column. According to the technical scheme, the problem that the micro-needle structure on the micro-needle module is easily damaged due to the fact that the micro-needle module shakes in the downward pressing process in the prior art is solved.

The utility model relates to the technical field of micro-needle dies, and discloses a magnetic micro-needle positioning forming die which comprises a lower die, a supporting plate is installed at the top of the lower die, grooves are formed in the two sides of the interior of the supporting plate, an upper die is installed at the top of the supporting plate, and ejection assemblies are fixedly connected to the two ends of the two sides of the supporting plate. The two ends of the two sides of the upper mold are both slidably connected with fixing assemblies. According to the magnetic type microneedle positioning forming die, after production is completed, the fixing assembly can be opened, and the upper die and the supporting plate can automatically move upwards under the action of the ejection assembly, so that a finished product is lifted up from the lower die, and the finished product can be taken out conveniently.

1. The name of the design product: RF micro needle (Genius RF 49). 2. The use of the design product: for RF micro needle. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view.

The utility model discloses an ophthalmic microscopic needle holding forceps with a locking function, which comprises a first clamping plate and a second clamping plate arranged opposite to the first clamping plate, the first clamping plate is hinged with the second clamping plate, a locking groove is arranged on the first clamping plate, a push block is arranged on the second clamping plate in a sliding manner, a clamping block is connected onto the push block, and the clamping block is connected with the locking groove. The clamping block is matched with the locking groove, and a clamping groove is formed in the clamping block. According to the needle holding forceps, when an object is clamped, only the first clamping plate and the second clamping plate need to be clamped, after the object is clamped, the clamping block can be inserted into the locking groove, when the object is clamped for a long time, the pushing block is pushed to enable the first clamping plate to be clamped into the clamping groove, and the first clamping plate and the second clamping plate cannot be separated after the needle holding forceps are released from the hand; therefore, the object does not fall off, an operator does not need to clamp the needle holding forceps forcefully for a long time, and finger fatigue is avoided.

The present invention relates to a composite mouse model simulating hyperuricemia exacerbated periodontitis and its establishment method and application. The establishment method comprises the following steps: step one: continuously injecting potassium oxonate into the peritoneal cavity of mice for 7 days; step two: on the 7th day, ligating a surgical thread to the maxillary second molar of the mice by using a micro needle holder; step three: continuing to continuously inject potassium oxonate into the peritoneal cavity of mice for 7 days to establish a composite mouse model simulating hyperuricemia exacerbated periodontitis. The hyperuricemia model constructed by potassium oxonate in the present invention can not only increase the uric acid level in a short period of time, but also maintain the uric acid level for a long time through continuous administration during the maintenance period. Combined with the construction of a mild and non-injurious periodontitis model, a composite mouse model of hyperuricemia exacerbated periodontitis is successfully simulated, effectively filling the gap in the lack of animal models in the research field related to hyperuricemia and periodontitis, and broadening the ideas and methods of clinical research hotspots.