187 results about "Preventative treatment" patented technology

Embodiments are directed to microneedle array devices for intradermal and / or transdermal interaction with the body of patient to provide therapeutic, diagnostic or preventative treatment wherein portions of the devices may be formed by multi-layer, multi-material electrochemical fabrication methods and wherein individual microneedles may include valve elements or other elements for controlling interaction (e.g. fluid flow). In some embodiments needles are retractable and extendable from a surface of the device. In some embodiments, interaction occurs automatically with movement across the skin of the patient while in other embodiments interaction is controlled by an operator (e.g. doctor, nurse, technician, or patient).

The present invention intended to provide an agent for preventing / treating Alzheimer's disease. More specifically, the present invention provides an agent for preventing / treating Alzheimer's disease, etc., which comprises a monoclonal antibody specifically reacting with a partial peptide at the C-terminal region of a β-amyloid or its derivatives.

An implantable medical device is disclosed comprising a high-density lipoprotein (HDL), recombinant HDL, high-density lipoprotein mimics (HDLm), or a combination thereof. Method are also disclosed for local and systemic administration HDL, recombinant HDL or HDLm for the prevention, treatment, or amelioration of a vascular disorder, disease or occlusion such as restenosis or vulnerable plaque.

Heterogeneous intimate admixtures of sulfated heparinic polysaccharides, well suited for the prophylaxis / treatment of acute thrombotic episodes in a human patient, comprise immixture of sulfated polysaccharides having a weight average molecular weight less than that of heparin and which include from 9% to 20% of polysaccharide chains having a molecular weight less than 2,000 daltons and from 5% to 20% of polysaccharide chains having a molecular weight greater than 8,000 daltons, the ratio between the weight average molecular weight and the number average molecular weight thereof ranging from 1.3 to 1.6.

The incorporation of one or more therapeutic agents on metallic and non-metallic medical prostheses is provided. The therapeutic agent can be used, for example, to prevent, treat, or reduce bacterial and fungal infections associated with these implants. Additionally, the therapeutic agents can be used to effect other therapeutic benefits. Specifically, a bilayer therapeutic coating is applied in two steps. Additionally, non-antimicrobial therapeutic agents may be incorporated in this coating to treat, prevent, modify, or stimulate certain clinical bioactivities.

The present invention provides 4-(3-Amino-phenyl)-5,6-dihydro-4H-[1,3]oxazin-2-ylamines of formula Ihaving BACE1 and / or BACE2 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and / or prophylactic treatment of e.g. Alzheimer's disease and type 2 diabetes.

Composition and methods for use in the therapeutic and preventative treatment, study, diagnosis and prognosis of liver related disease, inflammatory disease and related conditions are disclosed. Also provided are kits and reagents for prognosis and diagnosis of liver related disease, inflammatory disease and related conditions.

The present invention provides extended release compositions comprising neuregulin for preventing, treating or delaying various diseases or disorders. The present invention also provides methods for preventing, treating or delaying various diseases or disorders by extended release of neuregulin.

This invention provides for transgenic non-human mammalian models of human disease, methods of making such models as well as methods of using such models to assess efficacy of therapeutic and prophylaxis treatments, to assess the antigenic potential of compounds, and other uses.

A preventive / therapeutic composition for free radical diseases, characterized by containing as an active ingredient at least one of a fullerene, a fullerene derivative, and a composite comprising a fullerene or fullerene derivative and an organic compound with which the fullerene or derivative has been modified or clathrated. The composition is reduced in side effects, has the high ability to eliminate free radicals in the body, and further has excellent preparation stability.

Disclosed are methods of preventing, treating, or diagnosing in a subject a disorder in protein folding or aggregation, or amyloid formation, deposition, accumulation, or persistence consisting of administering to said subject a pharmaceutically effective amount of inositol stereoisomers, enantiomers or derivatives thereof.

The present invention relates to methods for the induction and a cell to enter the Islet 1+ (Isl1+) lineage and methods for expansion of cells of islet 1+ lineage. One aspect of the present invention relates to methods to induce a cell to enter the islet 1+ lineage, and more particularly to a method to induce a cell to enter a the Isl1+ lineage to become an Isl1+ progenitor that is capable of differentiating along multiple different lineages such as a endothelial lineage, a smooth muscle lineage or a cardiac lineage. In particular, one embodiment present invention relates to methods to induce a cell to enter the Isl1+ lineage by inhibiting a wnt signalling pathway in the cell. Another aspect of the present invention relates to methods to expand a cell of the Isl1+ lineage, such as a Isl1+ progenitor by activating a wnt signalling pathway in the Isl1+ progenitor. Another aspect of the present invention relates to use of cells of the isl1+ lineage in subjects for therapeutic and preventative treatment of cardiovascular diseases.

There is provided a continuous passive motion (CPM) machine with integrated mechanical deep vein thrombosis (DVT) prophylaxis for providing simultaneous CPM therapy and DVT prophylactic therapy to a human patient. The passive motion machine may include a base, at least one motor, one or more hinged frame rails, one or more support or suspension structures and a roller assembly. The hinged frame rails are driven to impart CPM to a patient's limb. The roller assembly can be a single roller, a multiple roller unit, or a belt and roller apparatus. A motor and connecting drive rotates the roller assembly. The roller assembly engages the patient's limb and the one or more rollers apply a mechanical DVT prophylaxis therapy to the limb, reducing the risk of blood clotting.

The present invention relates to the use of proboscis in nutritional compositions or medicaments for the prevention of treatment of gut-neuromuscular abnormalities. Such abnormalities are, for example, associated with colic in babies, gut-pain or gut discomfort in general. In particular, the invention relates to the prevention or treatment of gut neuromuscular abnormalities after infection. Proboscis may be administered in a living or dead state, and also supernatant of fermentation medium may be directly used to achieve the beneficial effects reported herein.

The invention relates to a Chinese medicinal feed additive for preventing and treating common diseases of chickens. The Chinese medicinal feed additive is prepared from the following selected raw materials according to parts by weight: radix scutellariae, rhizoma coptidis, golden cypress, milk veteh, fructus forsythiae, honeysuckle, rhizoma belamcandae, rhizoma atractylodis, fried bighead atractylodes rhizome, hawthorn, barley malt, medicated leaven, codonopsis pilosula and liquorice. A preparation method of the Chinese medicinal feed additive comprises the steps of mixing and then grinding the raw materials, or respectively grinding and then mixing the raw materials. The feed additive has the effects of strengthening body immunity to eliminate pathogenic factors, clearing away heat and toxic material, diminishing inflammation and invigorating stomach, sterilizing and disinfesting; by being mixed into daily feed for feeding, the Chinese medicinal feed additive can increase body immunity and disease resistance of chickens; and the feed additive is excellent in preventing and treating such common diseases of chickens as bird flu, new-area plague, salpingitis, white diarrhea, cholera,ascariasis, laryngotracheitis, coccidiosis and colon bacillus. Application proves that the Chinese medicinal feed additive has good preventing and treating effects, easily obtained materials, low cost and no toxic side effect.

The invention provides noodles with various tastes and long-acting preventive and curative effects on cold, and the preparation method thereof. The invention solves the problems of the noodles, such as single taste and no disease preventive effect. The noodles comprise, by weight parts: 90-100 parts of flour, 1-2.5 parts of flavoring agents and 10-15 parts of medicinal juice. The preparation method of the noodles comprises the steps of: mixing 90-100 parts of the flour, 1-2.5 parts of the flavoring agents and 10-15 parts of the medicinal juice by weight parts, stirring to form the dough and pressing into the noodles. The original drug effect of the medicinal juice is retained. On one hand, the drug durability is reinforced and the drug release time is prolonged due to the protein in the noodles. On the other hand, the drug taste is overwhelmed by using the flavoring agent. The noodles have the advantages of various tastes, abundant nutrition, long shelf life, and convenient transportation and processing, and stimulate the appetite.

It is intended to provide preventives / remedies for graft-versus-host disease and / or rejection in organ or bone marrow transplantation, rheumatoid arthritis, autoimmune diseases, allergic diseases, ischemic cerebral cell injury, myocardial infarction, chronic nephritis and arteriosclerosis. The above object can be achieved by preventives / remedies for graft-versus-host disease and / or rejection in organ or bone marrow transplantation, rheumatoid arthritis, autoimmune diseases, allergic diseases, ischemic cerebral cell injury, myocardial infarction, chronic nephritis and arteriosclerosis characterized by containing a specific compound having a CCR (CC chemokine receptor) antagonism.

The present invention provides pharmaceutical compositions in the form of relatively high molecular weight biocompatible polymers such as polyethylene glycol, optionally supplemented with a protective polymer such ad dextran and / or essential pathogen nutrients such as L-glutantine. Also provided are methods for preventing or treating gut-derived sepsis attributable to intestinal pathogens such as Pseudomonas aeruginosa by administering high molecular weight polyethylene glycol as well as methods for monitoring the administration of high molecular weight polyethylene glycol, such as in methods of preventing, ameliorating or treating microbe-induced epithelial disorders, as exemplified by gut-derived sepsis. Frequently, gut-derived sepsis arises as a complication in mammals recovering from surgical intervention or suffering from a disease or disorder, providing indications of suitable animals to receive preventative treatment. Finally, the invention provides a composition comprising infant formula and polyethylene glycol and methods for using that composition.

The invention relates to the field of veterinary medicines, in particular to a Chinese medicinal composition, a Chinese medicinal preparation and a feed for treating and / or preventing respiratory system diseases of livestock. The Chinese medicinal composition is prepared from gypsum, honeysuckle, indigowoad root, baical skullcap root, weeping forsythia, common anemarrhena rhizome, platycodon root and liquoric root. The Chinese medicinal composition, the Chinese medicinal preparation and the feed have the effects of freeing lung, relieving asthma, reducing phlegm, relieving cough, clearing heat and detoxifying, resisting bacteria, diminishing inflammation and improving the immunity of organisms, have a simple production process, are low in cost, do not have toxic or side effects, and can prevent and control various respiratory system diseases of the livestock, enhance the resistance of the organisms, avoid livestock diseases and improve the yield of livestock products.

An alkyl ether derivative represented by the following general formula [1]or its salt: wherein R1 and R2 represent each a substituent such as hydrogen, halogeno or alkyl; R3 represents alkylamino, amino or hydroxyl; the ring A represents a 5- or 6-membered aromatic heterocycle or a benzene ring; m and n are each an integer of from 1 to 6; and p is an integer of from 1 to 3; shows an effect of protecting retinal nerve cells and, therefore, is useful as a preventive and / or a remedy for retinal nerve diseases such as glaucoma, diabetic retinopathy, retinal artery obstruction, retinal venous obstruction, macular degeneration and retinopathy of prematurity.

A system and method is disclosed whereby a customer involved in a transaction is offered a benefit to be applied to the transaction in exchange for undertaking or agreeing to undertake some form of preventative treatment. The transaction may be a purchase of goods or services occurring, for example, over the Internet. In one embodiment, the customer may select an option whereby a third party, such as an insurer of the customer, will provide payment for at least part of the transaction, in exchange for the customer undergoing a preventative treatment. The preventative treatment may include a health treatment screening or test. The payment provided may be determined from an expected future savings in insuring the customer if the preventative treatment is undertaken. Payment may also be conditioned upon the customer's agreement to continue his or her insurance coverage with the insurer or to confirm that the preventative treatment was performed. In certain embodiments, the insurer may place a hold against a financial account for the value of the benefit until administration of the preventative treatment is confirmed.

A device and a method for preventive treatment of evolving pulmonary edema in patients which are at risk of complication associated with pulmonary edema which is based on the monitoring of internal thoracic impedance of the patient. The device extracts the internal thoracic impedance from measured trans-thoracic impedance and is relatively immune to variations in skin / electrode interface impedance. The method includes identification of a stage of interstitial edema development before the appearance of a clinical indication and the beginning of an appropriate medicinal treatment in accordance to variations of the monitored internal thoracic impedance. The method also indicates the appropriate moment for terminating the medicinal treatment and can be applied when the patient and his treating physician are positioned at remote locations.

The present invention relates to compositions, that may be swallowable, chewable or dissolvable, comprising various vitamins and minerals, and in a specific embodiment, comprise vitamin B6, vitamin B9, vitamin B12, calcium, vitamin D3, magnesium, and boron, and methods for using these compositions for nutritional supplementation in order to prevent, treat and / or alleviate the occurrence or negative effects of cardiovascular disease, colorectal cancer and osteoporosis.

Disclosed are sustained-release medicaments / drug compositions / formulations / therapeutics for the management of pain and inflammation associated disorders in general, more particularly arthritic inflammation. The sustained-release compositions comprise effective amounts of glucosamine, curcuminoids, boswellic acids and piperine.

The present invention provides liquid formulations of SYNAGIS® or an antigen-binding fragment thereof that immunospecifically bind to a respiratory syncytial virus (RSV) antigen, which formulations exhibit stability, low to undetectable levels of aggregation, and very little to no loss of the biological activities of SYNAGIS® or an antigen-binding fragment thereof, even during long periods of storage. In particular, the present invention provides liquid formulations of SYNAGIS® or an antigen-binding fragment thereof which immunospecifically binds to a RSV antigen, which formulations are substantially free of surfactant, inorganic salts, and / or other common excipients. Furthermore, the invention provides method of preventing, treating or ameliorating symptoms associated with RSV infection utilizing liquid formulations of the present invention.

The invention provides a device and method for monitoring inflammation of the epithelium. The device consists of a head region, a handle region and an optical bundle. At least two of the optical fibers in the bundle are utilized as a source of radiation, these two fibers are at two different angles from normal. At least one of the other optical fibers is utilized as a detector for the reflected radiation, or alternatively an image guide can be used as the detector. The device of the invention can be part of an external or internal system that can include a light source, the device, a multiplexer, a spectrometer, and a computer for data analysis. The method of the invention allows for the detection and monitoring of general inflammation of the oral epithelium. The inflammation of the epithelium can be detected or monitored to diagnose diseases of the oral epithelium, monitor such diseases, monitor treatment of such diseases, or pre-screen for and monitor preventative treatments of such diseases.

Compositions and methods for use in the therapeutic and preventative treatment, study, diagnosis and prognosis of PD-related disease are disclosed. Also provided are kits and reagents for prognosis and diagnosis of PD-related disease and related conditions.

The invention relates to acne treatment emulsion, and belongs to the field of cosmetics. The acne treatment emulsion comprises the following components: component A comprising propylene glycol, xanthan gum and first solvent; component B comprising 2-hydroxyethanesulphonic acid hexyl ether, vitamin B6 and second solvent; component C comprising plant extract, azelaic acid derivatives, dendranthema indica (L.) des moul, salicylic acid, ginseng extract, vitamin E and preservative agent. The acne treatment emulsion has the functions of treating acne, whitening and nourishing skin, moisturizing, reducing oil secretion, and promoting cellular metabolism, the effect is obvious, the action is fast, no acne scar is left after healing, and the acne is not easy to relapse; and the acne treatment emulsion is a cosmetic which is used for preventing and treating acne and whitening skin.

The invention relates to a use of angelica or an extract thereof in preparing skin care products, which belongs to a field of cosmetics. The angelica or the extract thereof have the advantages of adjusting skin secretion function, moisture keeping function, preventing and curing stains and promoting skin metabolism. The skin care products of the invention adopt the angelica or the extract thereof as main active components, which have remarkable effect on improving the complexion and healthy state of skin and provide a novel skin care selection for the public.