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Preventive/therapeutic composition for free radical disease

A disease prevention and disease treatment technology, applied in the direction of non-active ingredients of polymer compounds, antiviral agents, drug delivery, etc., can solve the problems of easy disappearance of activity, inability to fully exert free radical elimination, instability, etc.

Inactive Publication Date: 2008-01-02
VITAMIN C60 BIORES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these antioxidant substances are also extremely easily oxidized and unstable, and are easily oxidized and decomposed during or even after formulation, so it is difficult to maintain the quality of pharmaceutical preparations for a long time. Injection preparations, etc. cannot be subjected to heat sterilization such as autoclave treatment, so there is a problem that they cannot enter the living body in a stable state by intravenous injection or the like.
In addition, even if these existing antioxidants are administered orally or intravenously, there are problems that the activity in the living body is easily lost, and they are easily metabolized out of the body quickly, and the free radical scavenging effect cannot be fully exerted.

Method used

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  • Preventive/therapeutic composition for free radical disease
  • Preventive/therapeutic composition for free radical disease
  • Preventive/therapeutic composition for free radical disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0188] Embodiment 1: injection solution A

[0189] The mixture of cyclodextrin inclusion C60 fullerene and cyclodextrin inclusion C70 fullerene uniformly mixed in a weight ratio of 8:2 is completely dissolved in 1000cc of pharmaceutical Ringer's solution at a concentration of 178ppm. Sterile filtration is performed with a sterilizing filter for the production of injection solution, and an injection solution is produced as the drug for preventing and treating free radical diseases for intravenous injection of the present invention.

Embodiment 2

[0190] Embodiment 2: injection solution B

[0191] A mixture in which hydroxylated C60 fullerene with a hydroxylation rate of 87% (mole conversion) and hydroxylated C70 fullerene with a hydroxylation rate of 61% (mole conversion) was uniformly mixed in a weight ratio of 8:2, at 5ppm After being completely dissolved in 1000 cc of Ringer's solution for medicine, the injection solution was sterilized and filtered with a sterilizing filter for the manufacture of an injection to prepare an injection solution as the drug for the prevention and treatment of free radical diseases for intravenous injection of the present invention.

Embodiment 3

[0192] Example 3: Injection Solution C

[0193]Fullerenes manufactured by Bitamin C60 Biorisaichi Co., Ltd. under the trade name Radical Ponji (fullerene concentration: 200 ppm) were completely dissolved in 1000 cc of Ringer's solution for medicine at a concentration of 1%, and then used for the production of injections. Bacteria filter is carried out sterilizing filtration, and injection solution is manufactured as the preventive and therapeutic drug for free radical disease for intravenous injection of the present invention.

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Abstract

A preventive / therapeutic composition for free radical diseases, characterized by containing as an active ingredient at least one of a fullerene, a fullerene derivative, and a composite comprising a fullerene or fullerene derivative and an organic compound with which the fullerene or derivative has been modified or clathrated. The composition is reduced in side effects, has the high ability to eliminate free radicals in the body, and further has excellent preparation stability.

Description

technical field [0001] The present invention relates to a composition for the prevention and treatment of free radical diseases that exhibits preventive or therapeutic effects on various diseases related to free radicals, has stable formulations, has few side effects in vivo, and is highly safe. Background technique [0002] In recent years, carbon nanostructures represented by fullerenes have attracted attention as materials that open up new prospects for carbon materials. Based on electronic materials and electrode materials, their applications in medicine and medicine and to improve health etc. for the purpose of application attention is increasing. [0003] Fullerene molecules are composed of carbon atoms, and each sphere contains 32 to 1000 or more carbon atoms. For further detailed information on fullerenes, refer to the following documents: (i) Smalley (R.E.Smalley), "Atom ぉょび Molecular Kraster に ぉ ける Ultrasonic Carbon Crystal Kraster ビビ ム", ベルシュタイン (E.R.Berstein ) ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/01A61K8/31A61K31/02A61K31/045A61K31/395A61K33/44A61K47/40A61P1/02A61P1/04A61P1/14A61P1/16A61P1/18A61P3/04A61P3/06A61P3/10A61P7/02A61P9/04A61P9/06A61P9/08A61P9/10A61P9/12A61P17/00A61P17/02A61P17/08A61P17/10A61P17/14A61P17/16A61P19/02A61P25/16A61P25/18A61P29/00A61P31/00A61P31/16A61P31/18A61P35/00A61P37/02A61P39/06
CPCA61K9/145A61Q9/00A61K9/2866A61K31/395A61K33/44A61K8/19A61K8/738B82Y5/00A61K9/2027A61K47/48969A61K9/0014A61K9/06A61K47/34A61K47/32A61K45/06A61K9/0019A61K31/01A61K31/02A61K47/14A61K47/44A61K9/0095A61K31/045A61K2800/56A61K47/10A61K47/6951A61P1/02A61P1/04A61P1/14A61P1/16A61P1/18A61P3/04A61P3/06A61P3/10A61P7/02A61P9/04A61P9/06A61P9/08A61P9/10A61P9/12A61P17/00A61P17/02A61P17/08A61P17/10A61P17/14A61P17/16A61P17/18A61P19/02A61P25/16A61P25/18A61P25/28A61P29/00A61P31/00A61P31/16A61P31/18A61P35/00A61P37/02A61P39/06A61K2300/00B82B3/00C30B15/00H01L21/20
Inventor 三羽信比古伊东忍松林贤司
Owner VITAMIN C60 BIORES
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