668results about How to "Extended release time" patented technology

Biocompatible intraocular implants include a tyrosine kinase inhibitor and a biodegradable polymer that is effective to facilitate release of the tyrosine kinase inhibitor into the vitreous of an eye for an extended period of time. The therapeutic agents of the implants may be associated with a biodegradable polymer matrix, such as a matrix that is substantially free of a polyvinyl alcohol. The implants can be placed in an eye to treat or reduce the occurrence of one or more ocular conditions.

The invention relates to a poly-gamma-glutamic acid synergistic fertilizer for strengthening fertilizer effect, which belongs to the fertilizer field. The invention comprises graininess fertilizer which comprises the poly-gamma-glutamic acid. The contents of the poly-gamma-glutamic acid and fertilizer in weight are as follows: 0.01 to 1 percent of the poly-gamma-glutamic acid and the remained content is fertilizer. The contents of poly-gamma-glutamic acid of the invention are strictly controlled and the poly-gamma-glutamic acid can be conveniently fertilized. The poly-gamma-glutamic acid is combined with to make full use of the feature as absorption promoter of fertilizer of the poly-gamma-glutamic acid, therefore, crops output is further raised. The fertilizer is released slowly and prolonged by around 4 times compared with the traditional fertilizer in soil. The invention promotes crop absorption and inhibits fertilizer ingredient decomposition and loss, therefore, fertilizer use is directly decreased by more than 20 percent. The pollution to environment is reduced without excessive or inappropriate fertilization.

The invention relates to a preparation method of a slow-release pesticide. The method comprises the steps of: adsorbing a pesticidal active compound into a porous material; using a pore channel sealing material to seal the pore channels of a porous carrier; conducting further processing so as to obtain a suspending agent, powder, a granule, a tablet and other products of different preparation forms. The pesticidal active compound can be a pesticide, a bactericide, a herbicide or a plant-growth regulator. The preparation method of a slow-release pesticide in the invention can be used to prepare slow-release powder, slow-release granules, slow-release tablets, slow-release suspending agents and other products of different preparation forms so as to meet different demands of agricultural production, and can control the release of pesticidal active components into a surrounding environment at a predetermined speed or a low speed within a predetermined time. One-time application of a slow release pesticide prepared in the invention can control diseases, pests and weeds of a whole growth period (or a certain period). Thus, the slow-release performance of pesticides can be substantially enhanced, the release time can be prolonged, and long-time stable release of slow release pesticides can be maintained.

The invention relates to a preparation method of a gel containing stem cell exosomes for repairing skin wounds. The method comprises the following steps: 1) primary extraction and culture of human umbilical cord mesenchymal stem cells: 1.1) primary extraction of human umbilical cord mesenchymal stem cells, 1.2) subculture, and 1.3) collection of the culture supernatant; 2) extraction of human umbilical cord mesenchymal stem cell exosomes: 2.1) primary centrifugation, 2.2) secondary centrifugation, 2.3) removal of organelles by centrifugation, 2.4) coarse extraction of exosomes, and 2.5) finalextraction of exosomes; 3) preparation of a gel material: 3.1) preparation of chitosan, 3.2) configuration of beta-glycerol phosphate (beta-GP), and 3.3) preparation of the gel material; and 4) gel loading of the exosomes. The gel containing stem cell exosomes can promote repair of skin wounds, shorten the healing time of wounds and reduce scar formation.

The invention relates to a preparation method and application for efficient urea and a relative, and the preparation method and application is formed by the polymerization amino acid or the salt with a weight proportion of 0.01 to 2.0, urease inhibitor with weight proportion of 0.01 to 0.2, the nitrification inhibitor with weight proportion of 0.01 to 0.6, and the common urea with weight proportion of 97.2 to 99.97. The efficient urea is produced by adding the mixture solution of polymerization amino acid or the salt, the urease inhibitor and the nitrification inhibitor into the common urea at fusing state, and then mixing and granulating. The invention provides the application of the efficient urea in agriculture; for the field crop, the economic crop, the fruit and vegetable, and the flowers, the efficient urea can promote to comprehensively regulate the physiological and biochemical effect inside the plant so as to sufficiently excite the plant endogenous somatotropin and accelerate the nutrition producing, as well as improving the utilization and absorption of the urea, increasing the utilization rate by 20 percent to 60 percent. By the bonding effect of the polymerization amino acid or the salt molecule chemical bond and the effect of the urease inhibitor and the nitrification inhibitor, the invention slowly releases the urea in the soil, and increases the releasing time from 50 days up to around 120 days.

The invention relates to a spice slow-release filter tip additive with a polymer covering film as well as a preparation method and an application thereof, which belong to the technical field of cigarettes. The spice slow-release filter tip additive with the polymer covering film is of a three-layer sandwich structure, an inner core is made from porous materials, the covering film is made from polymers, and spices are fixed in a middle layer of the additive. The filter tip additive is added to a cigarette holder in an adding manner of ordinary filter tip particles, so as to prepare a cigarette. When the cigarette is smoked, the position of the particles in a filter tip is kneaded by hand, so that the spices in a sandwich layer are released, the aroma and flavor of smoke are increased, and the quality of the cigarette is increased. After the filter tip additive which is prepared by using the method is added to the cigarette, the non-burning section of the cigarette can be effectively perfumed, so that the aroma in an early manufacturing stage is prevented from being quickly volatilized, and the aroma and flavor of the cigarette can be kept for a long time.

The invention discloses a preparation method of a controlled release antibacterial film. The method includes the following steps of: (1) dissolving zein and a hydrophobic antibacterial agent into an alcoholic solution; (2) preparing a sodium caseinate aqueous solution; (3) adding the sodium caseinate aqueous solution into the solution obtained in step (1) under stirring; (4) subjecting the solution obtained in step (3) to rotary evaporation and centrifugation, then freeze drying the supernatant, thus obtaining nanoparticle powder; (5) dissolving a film-forming matrix in water, adding the nanoparticle powder and lysozyme to form a mixed solution; and (6) adding glycerin, and conducting film pouring, thus obtaining the film product. The method provided in the invention can simultaneously reduce initial microbial activity and inhibit microbial growth for a long term, and has the advantages of low instrument requirement, and controllable bacterium inhibiting intensity, thus having broad application prospects in food and medical products.

The invention relates to a thermo-sensitive poly N-isopropylacrylamide / polyurethane medicine-loading electro-spun fibrous membrane and a preparation method thereof, relating to a medicine-loading electro-spun fibrous membrane and a preparation method thereof and aiming to solve problems of poor mechanical property of existing poly N-isopropylacrylamide medicine-loading electro-spun fibrous membrane and no temperature sensitivity of a polyurethane medicine-loading electro-spun fibrous membrane. The thermo-sensitive poly N-isopropylacrylamide / polyurethane medicine-loading electro-spun fibrous membrane is prepared by poly N-isopropylacrylamide, polyurethane, N,N-dimethylformamide and a medicine; the preparation method comprises the following steps: 1, preparing static spinning solution; 2, dissolving the medicine so as to obtain the static spinning solution containing the medicine; 3, carrying out electrospinning; and 4, carrying out dry treatment to obtain the thermo-sensitive poly N-isopropylacrylamide / polyurethane medicine-loading electro-spun fibrous membrane. According to the invention, the preparation method is mainly used for preparing the thermo-sensitive poly N-isopropylacrylamide / polyurethane medicine-loading electro-spun fibrous membrane.

The invention relates to a Kangfu anti-inflammatory vaginal expansion suppository. The expansion suppository comprises active ingredients prepared from raw material medicines such as radix sophorae flavescentis, patrinia and Chinese violet, a matrix and an expansion carrier. The suppository is fully expanded, so that the medicine-containing matrix is fully contacted with the inner wall of the vagina, and external flow of the liquid medicine is avoided; the medicine-containing matrix in the expansion suppository also comprises a dispersing carrier, so that release of the active ingredients can be promoted, and the dissolution rate is improved. The invention also provides a preparation method and a detection method of the expansion suppository. The provided Kangfu anti-inflammatory vaginal expansion suppository employs seven ingenious advanced technologies and has the beneficial effects that the external flow of the liquid medicine is avoided, the stability is high, the effect is fast, the drug action time is long, and secondary infection is avoided.

The invention belongs to the field of pharmacy, and mainly relates to a composition of a compound sustained-release drug delivery system capable of alleviating pain for a long term and promoting woundhealing and application. The main drug of the system is a composition of a local analgesic drug and a non-steroidal anti-inflammatory drug, and further comprises a solvent and a corresponding sustained-release material. The main drug adopts a local analgesic drug and non-steroidal anti-inflammatory drug compound, the local analgesic drug can remedy the poor pain alleviating effect of the non-steroidal anti-inflammatory drug used alone, and can enhance the pain alleviating effect by reducing the pain sensitivity of an organism, inhibit inflammatory response and promote wound healing; and in addition, the combined use of the local analgesic drug and the non-steroidal anti-inflammatory drug can reduce the administration dosages of the local analgesic drug and the non-steroidal anti-inflammatory drug to reduce respective adverse reactions.

The invention relates to an amorphous calcium phosphate nanoball and a preparation method thereof. The preparation method comprises the following step of: with water-solubility calcium salt as a carbon source and phosphorus-containing biologic molecules as a phosphorus source, carrying out a hydrothermal reaction under assistance of microwaves to prepare the amorphous calcium phosphate nanoball. The amorphous calcium phosphate nanoball prepared by the method disclosed by the invention can stably exist in an aqueous solution for more than 140 hours, and can improve the biologic performance of the amorphous calcium phosphate and enhance the medicine loading capability of the calcium phosphate.

The present invention relates to a Xiaomi vagina expansion suppository, which comprises an active component, a matrix and an expansible expansion carrier. The present invention further relates to a preparation method and a detection method of the expansion suppository. According to the expansion suppository, seven original leading technologies are adopted; the expansion suppository is made into a hollow expansion suppository, and the matrix and the active component are completely separated, such that stability of the expansion suppository is increased compared with stability of the ordinary suppository; the active component, the dispersion carrier and the absorption blocking agent are combined so as to increase an active component dissolution rate, well release the active component, and prolong a drug action time; and the Xiaomi vagina expansion suppository has effects of rapid effect, prolonged action time, drug liquid outflow prevention, vagina cleaning, secondary infection prevention, and the like.

The invention discloses a composite biological carbon-based carrier with pesticide slow release performance and preparation method and application. The composite biological carbon-based carrier is prepared from modified biological carbon, a pesticide solution, sodium carboxymethylcellulose and bentonite. The preparation method comprises the following steps: A, washing rape stalks with water, drying, treating, smashing, and screening for later use; C, performing pyrolysis on the rape stalks at a certain temperature under the condition of limited oxygen to obtain biological carbon, treating the biological carbon with sodium hydroxide, washing with treated biological carbon with deionized water till the pH is constant, drying in a drying oven, and smashing to obtain the modified biological carbon; D, mixing the modified biological carbon with the pesticide solution to obtain a suspension-loaded pesticide, stirring at room temperature, uniformly mixing the sodium carboxymethylcellulose with the bentonite according to weight parts, aging for a certain time, and drying a solid substance in an air blast drying oven at a low temperature to obtain the composite carrier. The invention further relates to application of the composite carrier to rape cultivation. A composite controlled-release substrate does not generate any side effect on soil, has high environment compatibility, and can prolong the release time of the pesticide in soil.

The invention discloses a lanthanide rare earth coordinated cellulose medical material and a preparation method thereof. The medical material is prepared by oxidizing primary hydroxyl of cellulose into carboxyl and then coordinating with lanthanide rare earth metal ions, namely performing sol-gel self-assembling reaction to rare earth metal hydrate and cellulose the primary hydroxyl of which is selectively oxidized into carboxyl. The preparation method is simple in preparation technology and good in controllability. The material not only has excellent moisture absorption and preservation properties and breathability, and better biocompatibility and excellent degradability of cellulose materials, but also has antibacterial property of the rare earth complex, can be used for antibacterial and bacteriostasis wound dressing due to broad-spectrum antibacterial property, and can also be used for detection tracing, special marking and optical display of biomolecules; the lanthanide rare earth coordinated cellulose medical material can be prepared into powder, gel, thin films, sponge or other porous materials, thus expanding the clinical application range; and the lanthanide rare earth coordinated cellulose medical material can be doped or grafted with macromolecular compounds so as to enhance the antibacterial and bacteriostasis properties and promote therapeutic effect on wound recovery.

The invention relates to a halloysite nanotube drug sustained-release material and a preparation method thereof. The drug sustained-release material is prepared by the following steps: performing acid corrosion to a halloysite nanotube to obtain a dilated nanotube, loading the drug into an inner cavity of the halloysite nanotube, and coating an organosilane polymerized hydrophobic layer onto the surface of the drug-carried halloysite nanotube, wherein the during the coating of the organosilane polymerized hydrophobic layer, organosilane I is firstly used for modifying the outer surface of the halloysite nanotube, and then organosilane II is added to form the organosilane polymerized hydrophobic layer on the surface of the nanotube. Compared with the prior art, the sustained release material has universality on a hydrophobic drug and a hydrophile drug, the drug release time can be effectively prolonged, the encapsulation efficiency is high, and the administration safety of the drug can be improved.

The invention provides a salt-storage sustained-release snow-melt deicer and a preparation method thereof. The method comprises the following steps: firstly, respectively preparing an anticoagulationchloride saturated solution and a nano-silicon dioxide modified diatomite suspension; then, adding the anticoagulation chloride saturated solution into the nano-silicon dioxide modified diatomite suspension, stirring, filtering in vacuum, drying and grinding to obtain sustained-release inorganic salt; preparing a polymer monomer solution, sequentially adding the sustained-release inorganic salt, isopropyl alcohol or propylene glycol monomethyl ether solution into a flask, putting the flask in an oil bath, and uniformly stirring, adding the polymer monomer solution and a mixed solution of KH570and gAIBN, keeping on stirring, reducing the temperature, adding triethylamine into the flask, stirring, and adding water to obtain the salt-storage sustained-release snow-melt deicer. According to the salt-storage sustained-release snow-melt deicer, snow-melt substances are not limited by temperature-control molecules, and have long release time and relatively high ice melting capacity.

The invention provides a functional plant aromatic antibacterial cellulose fiber. The fiber comprises a microcapsule. The wall of the microcapsule is divided into an inner layer and an outer layer. The inner layer is made of polyacrylonitrile, and the outer layer is made of aerogel. The invention also provides a preparation method of the fiber. According to the preparation method, a plant essential oil primary aromatic microcapsule is prepared at first. The plant essential oil primary aromatic microcapsule is prepared by the following steps: adding plant essential oil into distilled water containing an emulsifier, and adopting a dual layer capsule wall, the dual layer capsule wall has the advantages that in the subsequent functional modification, the pH change will not damage the essential oil due to the dual layer capsule wall, and at the same time, the fiber has a new function. The inventor accidentally finds that the prepared fiber can store the effective components of natural plant derived fragrance. Moreover, compared with the prior art, the releasing effect of the microcapsule is better, and the releasing time is longer and more uniform.

The invention relates to biological ink for 3D printing of artificial skin, and belongs to the technical field of tissue engineering. The biological ink comprises a component A used for constructing an epidermal layer, a component B used for constructing a corium layer and a component C used for constructing an acellular matrix scaffold, wherein the component A comprises first seed cells, first carrier hydrogel and first growth factor slow-release gel containing traditional Chinese medicine components, and the mass ratio of the first carrier hydrogel to the first growth factor slow-release gelis (60: 1)-(60: 8); and the component B comprises second seed cells, second carrier hydrogel and second growth factor slow-release gel. The traditional Chinese medicine components such as dragon's blood and ampelopsis japonica and growth factor slow-release gel are added, and seed cells are extracted from the skin of a patient. The biological ink has good biocompatibility, can effectively promotecell proliferation and regeneration and wound healing, has good mechanical and fluidic properties, and can be used in 3D printing skin and other related fields.

The invention discloses a power supply clamping circuit for prolonging electrostatic discharge time. The power supply clamping circuit comprises a first RC time delay circuit module, a second RC time delay circuit module, an inverting circuit module and a discharge field effect tube, wherein the first RC time delay circuit module and the second RC time delay circuit module are connected with a source of the discharge field effect tube respectively, and are connected with a drain of the discharge field effect tube respectively; the second RC time delay circuit module is connected with a grid of the discharge field effect tube; the first RC time delay circuit module is connected with the second RC time delay circuit module through the inverting circuit module; the first RC time delay circuit module is used for conducting the discharge field effect tube for carrying out electrostatic discharge; when discharge time reaches a delay time coefficient of the first RC time delay circuit module, the second RC time delay circuit module is started to carry out electrostatic discharge on the discharge field effect tube; and when the discharge time reaches the delay time coefficient of the second RC time delay circuit module, the second RC time delay circuit module cuts off the discharge field effect tube.

A fertilizer special for roses comprises a base fertilizer and a foliar fertilizer. The base fertilizer comprises, by mass parts, 45-60 parts of nitrogen-phosphorus-potassium mixed fertilizer, 3-10 parts of medium elements, 0.5-5 parts of microelements, 0.1-0.4 part of compound inhibitor, 0.01-0.05 part of rare earth elements, 120-150 parts of organic fertilizer and 50-60 parts of zeolite powder. The ratio of the available nitrogen content, the available phosphorus content and the available potassium content of the nitrogen-phosphorus-potassium mixed fertilizer is (1.5-2):(2.5-3):(1-1.5); the foliar fertilizer comprises, by mass parts, 10-15 parts of ammonium dihydrogen phosphate, 5-10 parts of potassium sulfate, 2.5-4.0 parts of borax, 1-1.6 parts of magnesium sulfate, 2.0-3.2 parts of ferrous sulfate, 1.2-1.8 parts of zinc sulfate, 0.5-0.8 part of sodium selenite, 0.5-0.8 part of sodium molybdate, 45-60 parts of amino acid, 1.8-3.0 parts of Chinese herbal medicine extracting liquid, 0.5-1.0 part of glycerinum, 0.1-0.5 part of growth regulator, 0.01-0.03 part of surfactant, 0.01-0.03 part of potassium permanganate and 0.01-0.03 part of aspirin. The fertilizer special for the roses can meet nitrogen, phosphorus and potassium requirements of the roses, have good slow release characteristics and prolong flowering time of the roses.

A liquid medicine in the form of oral liquid or injection contains coenzyme Q10, liposome and buffer liquid proportional. It has high stability and biologic utilization rate.

The invention discloses a hydrogen-enriched water powder solid beverage. The hydrogen-enriched water powder solid beverage comprises the following ingredients in parts by weight: 80-90 parts of seaweed extracts or seaweed powder, 5-10 parts of resistance dextrin, 1-5 parts of maltodextrin, 1-5 parts of rice plumule extracts or rice plumule powder, 0.01-0.1 part of taurine, 0.01-0.1 part of vitamins, 0.01-0.1 part of potassium citrate, 0.4-0.8 part of sodium carbonate and 0.2-0.5 part of silicon dioxide.

The invention discloses a preparation method for an aerogel particulate in a cavity structure. The preparation method for a SiO2 aerogel particulate in the cavity structure comprises the following steps of wrapping metal particles by SiO2 aerogel, grinding and separating the SiO2 aerogel which wraps the metal particles, and drying to obtain the aerogel particulate which wraps the metal particles and is of a required size; soaking the aerogel particulate which wraps the metal particles in dilute acid, and slowly dissolving the metal particles; after the metal particles are completely dissolved, forming a cavity in the SiO2 aerogel particulate which originally wraps the metal particles due to dissolution of the metal particles, and performing washing, drying and heat treatment to obtain the SiO2 aerogel particulate in the cavity structure. The preparation method is simple. The prepared aerogel particulate in the cavity structure is stable in structure and can be used for medicine carrying and controlled release, and the particle size of the particulate is 1 to 10 microns.

The invention relates to calcium phosphate nano-structures and a preparation method thereof. According to the method, water-soluble calcium salt serving as a calcium source and phosphorous biomolecules serving as as a phosphor source are prepared into a calcium phosphate nano-structure powder through a microwave assisted hydrothermal reaction, wherein the phosphorous biomolecules are phosphofructose or fructose diphosphate. The three different nanostructures, namely amorphous calcium phosphate porous nano-spheres, hydroxyapatite nano-rods and amorphous calcium phosphate / hydroxyapatite composite nano-spheres, prepared by the preparation method can be widely applied to biomedicine, tissue engineering and other fields.

The invention discloses a 1-methyl cyclopropene slow release formulation and a preparation method thereof. The slow release formulation consists of 1-methyl cyclopropene as a core material and a covering film wrapping outside the core material, and the selected covering film is gelatin. The preparation method of the 1-methyl cyclopropene slow release formulation sequentially includes the following steps: dissolving the gelatin in water to formulate solution with the weight percentage of 2-10% and controlling the temperature of the solution between 1-4 DEG C; adding 1-methyl cyclopropene and stirring to form a gelatin-coated 1-methyl cyclopropene microemulsion; adding precipitating agent so that the microemulsion precipitates in the system and continuing to stir for 20-30min; adding a film-solidifying agent to solidify the covering film; fitering and then washing the solidified product to obtain a slurry 1-methyl cyclopropene microcapsule; and adding a separating agent in the slurry 1-methyl cyclopropene microcapsule so that the microcapsule disperses. The product is high in content of effective substances and long in slow release time. The preparation method is simple in technology and convenient in operation.

A method of using master control device to configure slave device in passive optical network system includes generating its supported management ability information by slave device according to its own hardware configuration and configuring slave device by master control device according to management ability information supported by slave device.

The invention discloses a non-firework slow releasing device for connection and unlocking of a wire type separating device. The non-firework slow releasing device comprises a left rotating screw rod,a right rotating screw rod, a shell, a slowly opening device and an unlocking device, wherein the slowly opening device is connected with the unlocking device; the slowly opening device and the unlocking device are arranged inside the shell; the unlocking device can be used for making the slowly opening device rotate; the left rotating screw rod is connected with the slowly opening device throughthe shell; and the right rotating screw rod is connected with the slowly opening device through the shell. The non-firework slow releasing device disclosed by the invention improves the safety of thedevice, has repeated test capability and also reduces the separation impact.

The invention discloses a method for preparing amifostine microspheres, comprising the following steps: adopting an emulsification-solvent evaporation method to dissolve biodegradable polymers into organic solvents, adding surfactant, mixing with amifostine aqueous solution, emulsifying the mixture by an ultrasonic emulsifier, dispersing emulsion into polyvinyl alcohol aqueous solution to undergofurther ultrasonic emulsification to form w / o / w type emulsion, carrying out magnetic stirring on the w / o / w type emulsion under low temperature to volatilize the organic solvents, then carrying out centrifuging, washing and freeze drying to obtain the amifostine microspheres. By using the method of the invention, the organic solvent is low in usage amount, the preparation time is short, the grain sizes of the microspheres are controlled between 400nm and 900nm and the in-vitro release time of the microspheres lasts as long as 75-100h.

The invention discloses an oil-in-water type nanometer emulsion adjuvant and MRSA nanometer emulsion adjuvant vaccine and a preparing method thereof. The nanometer emulsion adjuvant is prepared from, by mass, 1-30% of surface active agent, 0.1-15% of cosurfactant, 0.1-15% of oil phase and 40-98.8% of water; the adjuvant is clear and transparent liquid from appearance, the particle size ranges from 1 nm to 100 nm, viscosity is low, the adjuvant belongs to a highly thermodynamics stabilizing system, and therefore high-speed centrifugation is stable without layering; when being compatible with the vaccine, the adjuvant can wrap the vaccine or be directly mixed with the vaccine physically for use, and immunity can be achieved by means of administration routes such as intramuscular injection and nasal drip. The adjuvant has the advantages of being low in cost, convenient to administrate, small in toxicity, good in liquidity and small in irritation to organism, and avoiding cross infection, the immune effect and stability of the vaccine are effectively improved, and the adjuvant has a wide application prospect.

The invention discloses a risperidone nano-suspension temperature sensitive gel and its preparation method. Each 100ml of the nanosuspension temperature sensitive gel contains 0.1-10g of risperidone, 0.1-5g of a stabilizer, 1-50g of a temperature sensitive gel material, 0-5g of an additive, and the balance of a water-based solvent. The risperidone nano-suspension temperature sensitive gel is a temperature sensitive controlled-release in situ gel. The above dosage form makes risperidone highly dispersed, so the gel has the advantages of good drug load and good stability; after the gel is administrated in a liquid form, phase transition occurs in applied sites, and the liquid becomes non-chemically-crosslinked semisolid gel, so the gel has good histocompatibility and improves the drug dissolution rate; and the administrated gel has a long retention time in the applied sites as a drug reservoir, so the gel has a slow release effect, prolongs the drug release time, improves the drug bioavailability, reduces the administration frequency and improves the drug effect and the patient compliance.