22results about How to "Extended release time" patented technology

The invention provides a fiber dressing for promoting wound healing and a preparation method and application thereof, and belongs to the technical field of biological materials. The shell of the fiber dressing contains the first medicine for promoting polarization of macrophages, and the first medicine can promote polarization of macrophages at normal and diabetic wound surfaces from M1 type to M2 type; a shell substrate is a mixture of hydrophilic and hydrophobic polymers, so that painless adhesion and stripping of a wound surface can be realized by absorbing seepage and spraying non-irritant normal saline on the wound surface, and secondary injury of the wound surface is reduced; an inner core contains a second medicine and a third medicine which are used for inducing death of M1 type macrophages, so that wound inflammatory response can be reduced, wound bacteria can be killed, wound infection degree can be reduced, and wound healing can be accelerated; the core matrix is a mixture of hydrophilic and hydrophobic polymers with good biocompatibility, can provide mechanical support for the fiber dressing, and provides a slow release effect for the two substances in the core. By controlling the composition of the inner core and the shell, the healing of normal wounds and diabetic wounds can be effectively promoted.

The invention belongs to the field of drug preparation, and particularly relates to a preparation method and application of a drug delivery system based on hollow mesoporous polydopamine nanoparticles. The drug delivery system comprises hollow mesoporous polydopamine nanoparticles, a drug loaded inside and / or outside the hollow mesoporous polydopamine nanoparticles, and pectin wrapping the hollow mesoporous polydopamine nanoparticles, the medicine is a medicine with a nerve protection effect and an acetylcholin esterase inhibitor. The drug delivery system can reduce proinflammatory cytokines, regulate functions of target immune cells, synergistically reduce necrosis of neurons in intestinal tracts and induce neural crest stem cells in the intestinal tracts to be differentiated into neurons.

According to the antibacterial and antioxidant composite film applied to food preservation and the production method of the antibacterial and antioxidant composite film, the chlorogenic acid, the catechin, the montmorillonite and the zeolite are introduced, and a drying process is optimized, so that the antibacterial performance, the antioxidant performance and the mechanical performance of the preservative film are remarkably improved, and meanwhile, the water vapor permeability and the oxygen permeability are reduced. The method comprises the specific steps of raw material preparation, polyphenol compound and mineral substance preparation, membrane liquid preparation and treatment, drying process optimization and finished product membrane uncovering. According to the preparation method disclosed by the invention, components such as chlorogenic acid, catechin, montmorillonite and zeolite are introduced, and a drying process is optimized, so that the food preservative film with synergistic antibacterial and antioxidant properties is prepared.

This invention relates to the field of pulse circuit technology and discloses a high-efficiency AC power line zero-crossing detection chip, including a path selection module, a signal processing module, and a driving module. The path selection module switches the charging circuit according to the potential of the internal power supply capacitor. The signal processing module uses a feedback loop to adjust the switching level of the sampling branch and generate a zero-crossing trigger pulse signal. The driving module responds to the zero-crossing trigger pulse signal by segmentally turning on the internal power supply capacitor and the external energy supply capacitor in the initial and subsequent stages of the zero-crossing point. This invention solves the contradiction between the ultra-high input impedance sampling environment and the driving strength through a controlled hysteresis window and a segmented current injection mechanism, suppresses signal jitter, improves the timing accuracy of zero-crossing detection, and effectively reduces the static power consumption of the system.

The invention discloses an insect trapping plate containing pheromone-urea resin microcapsules. The insect trapping plate comprises colored body paper or a fiber material, a barrier release layer containing the pheromone-urea resin microcapsules and insect sticking glue, the barrier layer containing the pheromone-urea resin microcapsule is prepared from 1 to 3 parts of pheromone, 95 to 97 parts of urea resin and 1 to 3 parts of an emulsifier; wherein the pheromone is composed of a plurality of components selected from trans-2-hexenal, 1-pentene-3-alcohol, violet ketone, linalool, cis-3-hexene-1-alcohol, and phenoxyethanol, and the pheromone is composed of a plurality of components selected from the group consisting of 2-hexenal, 1-pentene-3-alcohol, violet ketone, linalool, cis-3-hexene-1 The urea-formaldehyde resin is urea-formaldehyde resin jointly modified by melamine and polyvinyl alcohol. The invention further provides a preparation method of the insect trapping plate containing the pheromone-urea resin microcapsules. The insect trapping plate provided by the invention releases pheromones in a long-acting manner, and the insect trapping effect is lasting; and after being buried, the fertilizer can be used as a fertilizer to provide nitrogen necessary for growth of crops.

The invention discloses a potassium sulfate fertilizer and a marking method thereof. The marking method comprises the following steps: S1, mixing rubidium sulfate and potassium sulfate powder to obtain a mixed reagent; s2, preparing the rubidium sulfate and potassium sulfate mixed reagent into a saturated solution; s3, heating and evaporating the saturated solution to obtain marked potassium sulfate fertilizer particles. The physical and chemical properties of the obtained marked potassium sulfate fertilizer test product are similar to those of the existing potassium sulfate fertilizer, replacement of fertilizer application can be realized, a soil potassium source and a fertilizer potassium source can be distinguished, the absorption and utilization effects of crops on different potassium sources are further determined, and a more reliable method is provided for reasonable application of the potassium fertilizer.

The invention discloses a preparation method and application of nano sponge hydrogel loaded with alkannin. Beta-cyclodextrin and a BTDA cross-linking agent are subjected to cross-linking reaction through esterification reaction to prepare cyclodextrin nano sponge with a porous structure, and alkannin is stably loaded in the cyclodextrin nano sponge through subject-object interaction; the loading capacity of the alkannin can be improved, the slow release effect of the alkannin can be improved, and the drug release time can be prolonged; according to the present invention, the shikonin is used as a main body and is combined with the gel formed by the QCS and the PVA, and the adhesion with the skin is increased by using the high-viscosity hydrogel, such that the long-time pasting on the skin can be used, the slow release effect can be further improved, the shikonin bioavailability can be improved, the treatment effect can be improved, the drug use frequency can be easily reduced, and the secondary injury of the wound can be avoided; the wound healing can be better promoted. The preparation method disclosed by the invention is simple to operate and low in cost, has good stability and biocompatibility, and can remarkably improve the capability of promoting wound healing.

The present invention relates to the field of animal feed technology, and in particular to a pet food that is easily digestible and absorbable and a preparation process thereof. The preparation process comprises the following steps: preparing a chitin nanofiber suspension; preparing a modified pig liver protein solution; preparing a digestive aid additive; and preparing a pet food that is easily digestible and absorbable. The present invention improves the solubility of pig liver protein in water and makes it easier to disperse by grafting maleic anhydride onto pig liver protein. Pig liver protein is rich in high-quality protein. For pets, excessive high-quality protein is not easy to absorb, but will result in overnutrition. After pig liver protein is grafted with maleic anhydride, the surface properties of the protein are changed, which can better improve the absorption rate of organisms. In addition, the introduction of maleic anhydride can reduce the protein content in the modified pig liver protein solution, so that the protein content in the prepared pet food is within the range that the pet can absorb, and the prepared pet food is easy to digest and absorb.

The present application relates to a kind of gel type chlorine dioxide slow-release agent and its preparation method, to solve the defects of chlorine dioxide gas instability, short storage time of disinfectant product in prior art, the gel system of the present application includes: chlorite aqueous solution, gelling agent, graphene oxide, PH regulator and activator, the present application uses graphene oxide as chlorine dioxide gas regulator, utilizes the better adsorption performance of graphene oxide and its surface oxygen-containing functional group, synergistic effect with gelling agent, so that the reaction of chlorine dioxide gas is like a super micro chemical processing plant, establishes a "constantly evaporating, constantly replenishing" chlorine dioxide balance system, continuously releases chlorine dioxide gas, kills a variety of bacteria and viruses in air, purifies air, no secondary pollution, and low price.

The invention discloses a composite material for continuous lithium extraction based on photo-thermal synergy, a supercooled continuous lithium extraction method and application, and belongs to the technical field of salt lake lithium extraction and heat energy management. According to the prepared floating type photo-thermal synergistic lithium extraction composite material, through the design of a three-layer composite structure, the synergistic function of temperature regulation and control, lithium ion adsorption and structure supporting is achieved, the problems that a traditional lithium adsorption material is prone to sedimentation and usually needs an additional supporting structure are solved, the density is smaller than that of water, and the composite material can stably float on the surface of salt lake brine; and large-scale deployment and recovery are facilitated.

According to the energy storage cabinet electric core level fire extinguishing system and method, the structure is simple, the fire source is accurately aligned, the fire extinguishing agent spraying time is more accurate, and the continuous fire extinguishing time is longer. The system comprises a fire extinguishing medium storage device, a fire detection tube, a composite detector, a trigger and a controller, wherein the controller is in communication connection with a system background; the fire-fighting method of the system comprises the following steps: a, when a combustion factor is detected, the controller controls the system to stop; b, the composite detector drives a trigger to trigger a fire extinguishing medium storage device to release a fire extinguishing medium into the fire detection tube; c, giving an alarm and informing the smoke exhaust fan to work; d, when the fire detection tube is softened by high-temperature open fire and exploded by the high-pressure fire extinguishing medium, releasing the fire extinguishing medium to a fire source point of the battery cell; and e, when the fire is not extinguished or the battery core is re-combusted, triggering the glass ball of the spray head to be exploded at high temperature, and injecting fire-fighting water into the energy storage cabinet through the fire-fighting pipeline to extinguish the fire. The method is applied to the technical field of new energy and energy storage.

The invention relates to a controlled-release linalool emulsion based on a ternary system as well as a preparation method and application of the controlled-release linalool emulsion. The linalool emulsion is an oil-in-water Pickering emulsion composed of a water phase and an oil phase, the water phase comprises a ternary system composed of soybean protein isolate, pectin and hydroxypropyl methyl cellulose, and the oil phase is linalool essential oil. The preparation method comprises the following steps: respectively preparing soybean protein isolate, pectin and hydroxypropyl methyl cellulose solutions, and mixing to obtain a ternary composite water phase; and mixing the ternary composite water phase with the oil phase, and carrying out high-pressure homogenization treatment and ultrasonic treatment under a low-temperature condition to obtain the controlled-release linalool emulsion based on the ternary system. Compared with the prior art, the linalool essential oil emulsion embedding method solves the problem that linalool is easy to volatilize, and can be used in the fields of fruit and vegetable fresh keeping, tea fragrance maintaining and the like.

The application discloses an intestinal-targeted controlled-release microalgae pharmaceutical composition, which comprises a hydrophobic drug, a micellar material and microalgae, wherein the hydrophobic drug is first loaded on the micellar material to form a drug-loaded micelle, the solubility of the hydrophobic drug is improved, and the drug-loaded micelle solution penetrates into the interior of the microalgae cells through a passive water absorption process of dried microalgae instead of being attached to the surface of the microalgae. The natural cell wall of the microalgae itself is solid and acid-resistant, which is used as a first physical barrier to prevent the release of the hydrophobic drug in a gastric acid environment, and the effective concentration and residence time of the hydrophobic drug in the intestinal action site are significantly improved, so that the treatment effect is better, and the intestinal disease and kidney disease drug can be prepared.

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating scalds and a preparation method and application thereof. The traditional Chinese medicine composition for treating scalds is prepared from the following components: 10 to 15 parts of radix et rhizoma rhei, 10 to 15 parts of radix sanguisorbae, 10 to 20 parts of radix angelicae sinensis, 5 to 10 parts of rhizoma coptidis, 5 to 10 parts of cortex phellodendri, 10 to 20 parts of fructus gardeniae, 5 to 10 parts of rhizoma polygoni cuspidati, 5 to 10 parts of elm bark inner layer, 5 to 10 parts of herba portulacae, 5 to 10 parts of flos lonicerae, 2 to 5 parts of borneol, 0.1 to 0.5 part of preservative, 1 to 3 parts of humectant and 0.5 to 2 parts of thickening agent. By adopting the combination of multiple Chinese herbal medicines such as rheum officinale, raw sanguisorba officinalis, angelica sinensis, coptis chinensis, golden cypress, cape jasmine, polygonum cuspidatum, elm bark inner layer, purslane and honeysuckle, the synergistic effect of the traditional Chinese medicines is fully utilized, and the remarkable technical effects of clearing away heat and toxic materials, relieving swelling and pain and promoting wound healing are achieved. Compared with the technical scheme of single Chinese herbal medicine or simple mixing in the prior art, the medicine composition has the advantages that the comprehensiveness and the treatment effect of the medicine effect are remarkably improved, and the healing speed of scalds is increased.

The application provides an antifouling composite material and a preparation method and application thereof. The antifouling composite material is prepared from 100 parts by weight of a polymer matrix and 1-100 parts by weight of a slow-release filler, wherein the polymer matrix is a polyurethane with a main chain capable of being degraded into non-toxic small molecules, and the slow-release filler is halloysite nanotubes loaded with an antifouling agent. The polyurethane of the application can be continuously degraded into non-toxic small molecules, and the slow-release filler can release the antifouling agent for a long time, and the combination of the two guarantees the continuous dynamic updating of the surface of the composite material and excellent dynamic / static long-term antifouling performance. The antifouling composite material provided by the application can be coated on the surface of marine engineering equipment to form a long-term protection circle around the marine engineering equipment and prevent marine organisms from adhering or growing on the surface of the equipment.

The application discloses a W / O / W compound emulsion and a preparation method and application thereof. The preparation method of the compound emulsion comprises the following steps: mixing cinnamyl aldehyde and hydrophobic bacterial cellulose with oil to prepare an oil phase; mixing the oil phase with a nutritional ingredient aqueous solution to prepare a W1 / O primary emulsion by homogenously emulsifying; mixing the W1 / O primary emulsion with an aqueous solution W2 containing bacterial cellulose to homogenously emulsify, and the W / O / W compound emulsion is obtained; and the hydrophobic bacterial cellulose is obtained by hydrophobic modification of bacterial cellulose. The cinnamyl aldehyde in the oil phase is released to the outside at the same time as the nutritional ingredient in the inner aqueous phase, so that the released nutritional ingredient is prevented from being polluted by bacteria, the antibacterial time is prolonged, and the shelf life of the compound emulsion is prolonged. In addition, the bacterial cellulose is used as a water-soluble emulsifier to stabilize the O / W2 emulsion, and the hydrophobic bacterial cellulose is used as an oil-soluble emulsifier to stabilize the W1 / O emulsion, so that the compound emulsion has good biocompatibility, safety and stability.

The invention belongs to the field of starch processing, and relates to a preparation method and application of an anti-digestion corn starch complex gel polymer. The preparation method comprises the processes of plant protein pretreatment, protein cross-linking, corn starch gelatinization cross-linking and the like, the anti-digestion corn starch complex gel polymer is obtained, the dosage of cross-linking enzyme is 1-50 U / g of plant protein, the mass ratio of corn starch to plant protein is (2-8): 1, the concentration of the plant protein is controlled to be 0.01-0.05 g / mL, and the concentration of polyphenol is controlled to be 0.0005-0.002 g / mL. The anti-digestion corn starch complex gel polymer obtained by the method provided by the invention has low expansibility, excellent freeze-thaw stability and higher thermal stability, has slow digestion and resistant starch content of 40% or more, can be used as a drug sustained-release auxiliary material and a low-glycemic-index food ingredient, and has a wide application prospect. The composition has excellent physiological functions, such as improvement of intestinal health, prevention of diabetes, weight control and the like, and is widely applied.

The invention provides a method for preparing a double-layer coated urea slow-release fertilizer by using sulfamic acid modified cellulose and application of the double-layer coated urea slow-release fertilizer, and relates to a preparation method of an environment-friendly coated slow-release fertilizer. The invention aims to solve the problems that the utilization rate of urea in the existing fertilizer is low, secondary pollution is easily caused by non-degradability of most slow-release fertilizer coated matrix materials, and straw cellulose is poor in dissolvability and is not beneficial to being used as a slow-release fertilizer coated matrix. Comprising the following steps: 1, preparing sulfamic acid modified cellulose; and 2, preparing the sulfamic acid modified cellulose double-layer coated urea slow-release fertilizer. According to the method, the biomass straw is used as a raw material for cellulose extraction, the defects of poor solubility and poor thermoplasticity of the cellulose are overcome through chemical modification, and resource utilization of the straw can be achieved. In addition, the prepared slow-release fertilizer has the advantages of being simple in process, low in cost, environmentally friendly, degradable in matrix and the like, and is suitable for large-scale preparation and agricultural production.

The invention provides a medicine carrying system for treating corneal scars based on Tbeta4 and EISA hydrogel, the medicine carrying system is formed by covalently connecting the Tbeta4 and an EISA hydrogel skeleton, the Tbeta4 is a peptide fragment TB500 with an active function, the EISA hydrogel skeleton selects a YYY hydrogel skeleton Nap-YYY-G, and the formed medicine carrying system is YYY-TB500. By combining the anti-fibrosis effect of the Tbeta4 and the drug delivery advantage of the EISA polypeptide hydrogel, the delivery efficiency and drug effect of the Tbeta4 can be effectively improved, so that the repair process after corneal injury is improved, scar formation is reduced, and a new thought and treatment means are provided for treatment of corneal injury and scar.

The diaphragm type silk fibroin microneedle patch sequentially comprises a medicine storage layer, a diaphragm layer and a blank microneedle layer, the blank microneedle layer is composed of silk fibroin and comprises a base body and a needle body extending outwards from the base body, and the side, away from the needle body, of the diaphragm layer is covered with the medicine storage layer; the medicine storage layer comprises silk fibroin and tranexamic acid, and the diaphragm layer is located between the medicine storage layer and the blank microneedle layer. According to the tranexamic acid-loaded diaphragm type silk fibroin microneedle patch containing the medicine storage layer, the release duration (14 h in vitro and 24 h in vivo) can be increased, a large tranexamic acid concentration difference can be formed between the microneedle and the skin, stable pushing force is provided for transdermal release of tranexamic acid, the stable medicine release rate is achieved after a certain time, and the transdermal effect of the tranexamic acid is improved. Therefore, the purpose of long-time stable administration is achieved.

The present invention discloses an ultra-thin flexible neural electrode array that is easy to release and a preparation method thereof. The present invention utilizes spin-coated sodium polystyrene sulfonate PSS as a release sacrificial layer, and utilizes the strong hydrophilicity of PSS to make it easier to detach from the substrate when releasing the device. The release process described does not involve harmful reagents such as strong acids and strong bases. Before the release operation, it is compatible with traditional micro-nano processing technology, including compatible processing steps such as lithography, etching, and deposition. By adding release materials in specific areas, the release time of the ultra-thin flexible electrode can be greatly accelerated to protect the integrity of the flexible electrode. The present invention is easy to operate and can easily release ultra-thin flexible neural electrode arrays of different sizes.

The invention relates to the technical field of fertilizers, and particularly discloses a preparation method of a slow-release vitamin B3 waste liquid fertilizer, which comprises the following steps: filtering and neutralizing a vitamin B3 waste liquid, adding a base material additive into the vitamin B3 waste liquid, and stirring and mixing to obtain a waste liquid base material; the preparation method comprises the following steps: adding a waste liquid base material into a stirrer, dropwise adding isobutylidene diurea and polyacrylamide at the same time, dropwise adding a controlled release agent into the waste liquid base material, standing and cooling to room temperature to obtain a fertilizer base material; adding deionized water into the fertilizer base material, and heating the fertilizer base material to obtain a granulation base material; the granulation base material is placed in granulation equipment for granulation, and the coating agent is sprayed to the granulation surface to obtain the fertilizer granules, so that the release rate of the fertilizer base material is reduced, the action duration of the fertilizer on crops is prolonged, and meanwhile, the fertilizer cannot quickly absorb water when just applied to wet soil; quick release of the fertilizer is avoided, and the acting time of the fertilizer is prolonged.