62results about How to "Reduce secretion" patented technology

The invention relates to lactobacillus crispatus LC30 for preventing and treating female genital tract infection and application of the lactobacillus crispatus LC30. The lactobacillus crispatus LC30 is preserved in the China General Microbiological Culture Collection Center with the preservation number of CGMCC NO.31923. The lactobacillus crispatus LC30 has good hydrogen peroxide production capacity and adhesion capacity, has a strong inhibition effect on main vaginitis pathogenic bacteria, and can be used for preventing and treating female genital tract infection. The composition is effective to nutritional pathogenic bacteria, and can also reduce form transformation and biological membrane formation of the pathogenic bacteria and prevent and treat drug resistance; besides, the fermentation product can reduce the content of pathogenic bacteria metabolites, regulate the secretion of cytokines and achieve the effect of relieving inflammation, so that the fermentation product can be used for preparing products for preventing and treating genital tract pathogenic bacteria infection, preventing and treating vaginitis and / or removing pudendum peculiar smell.

The invention provides a culture method for improving immunity of fishes. The culture method comprises the following steps: S1, selection of culture points; S2, specification and layout of net cages; S3, selection and throwing of fish fries; according to the fry disinfection method disclosed by the invention, the fry are soaked and disinfected by using a compound disinfectant prepared from povidone iodine, polysorbate, citric acid and vitamin C in a specific proportion, so that pathogenic microorganisms on the surfaces and gill parts of fish bodies are effectively killed. According to the breeding management, the immunity of the fish body is comprehensively enhanced by feeding the fish with an immune conditioner composed of campesterol palmitate, immunomodulatory peptide, beta-glucan and astaxanthin in a specific proportion. According to the bottom mud management, the content of harmful substances is reduced by putting a bottom mud modifier composed of sodium molybdate, nitrifying bacteria, photosynthetic bacteria, tetrandrine and sodium alginate in a specific proportion, growth of pathogenic bacteria is inhibited, nutrient substance circulation is promoted, the water quality environment is optimized, and healthy growth of fry is promoted.

The invention relates to the field of cosmetics, in particular to a berry composition for scalp care and a preparation method and application thereof, and the preparation method comprises the following steps: A, pretreating fruits to obtain berry freeze-dried powder; b, preparing a deep eutectic solvent; c, mixing the berry freeze-dried powder with the deep-eutectic solvent, and performing oscillation extraction to obtain a berry procyanidine crude extract; d, purifying the berry procyanidine crude extract with macroporous resin to obtain a first purified berry procyanidine product; e, removing the solvent from the first purified berry proanthocyanidins to obtain a second purified berry proanthocyanidins; and F, dissolving epicatechin, mixing the dissolved epicatechin with the second purified product of the berry procyanidine, uniformly heating in a vacuum environment, cooling after relieving the vacuum environment, mixing with amino acid hydrochloride, and preserving heat to obtain the berry extract.

The invention provides a traditional Chinese medicine compound for treating sicca syndrome and a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicine compounds. The traditional Chinese medicine compound provided by the invention has the effects of eliminating dampness and heat, removing blood stasis and promoting salivation, can safely and effectively treat sicca syndrome by improving functions of exocrine glands and regulating immunity, belongs to a pure traditional Chinese medicine preparation, and has no toxic or side effect. The traditional Chinese medicine compound is proved to be capable of remarkably relieving the sicca syndrome, relieving dry mouth and eye symptoms of a patient, relieving fatigue, regulating and controlling a plurality of signals taking RAGE / TLR4 as a core, inhibiting excessive activation of an HMGB1-RAGE / TLR4-NF-kappa B pro-inflammatory pathway from gene and protein levels, inhibiting generation of pro-inflammatory cytokines, reducing inflammatory response and improving the immunity of the patient. The effect of treating the sicca syndrome is achieved. By acting on STAT3 phosphorylation, Tfh proliferation is inhibited, IL-21 secretion is reduced, humoral immune disorder is relieved, and the sicca syndrome is treated, so that the condition of the sicca syndrome is relieved, and the prognosis of the sicca syndrome is improved.

The invention provides a nano preparation for breaking oxidative stress-inflammation vicious circle and regulating intestinal flora as well as a preparation method and application of the nano preparation. The preparation method of the preparation comprises the following steps: dissolving potassium ferricyanide and polyvinylpyrrolidone in a solution, slowly dropwise adding a zinc acetate dihydrate solution into the solution, stirring, standing, and repeatedly performing ultrafiltration centrifugal washing to obtain zinc-doped Prussian blue; crushing the yeast cells to obtain yeast cell walls; the yeast cell wall and the zinc-doped Prussian blue are repeatedly co-extruded through a liposome extruder to obtain the nano preparation. The ZnPBA in the nano material can efficiently remove active oxygen at an inflammation part and reduce secretion of inflammatory factors, and the oxidative stress-inflammatory vicious circle of ulcerative colitis is broken; meanwhile, the YCW can deliver the ZnPBA to an inflammation part in a targeted manner to kill pathogenic escherichia coli, and mannose components can promote growth of probiotics to realize bidirectional regulation of intestinal flora. The material is simple in preparation method, can be synthesized on a large scale and is used for treating ulcerative colitis.

The invention provides application of baicalin in preparation of a medicine for treating streptococcus agalactiae induced mastitis, and relates to the technical field of medicine. A mouse is selected as an animal model to research the intervention effect and mechanism of the baicalin on the streptococcus agalactiae induced mouse mastitis inflammatory response, and it is clear that the baicalin can play a role in protecting the mouse mammary gland by regulating and controlling an NLRP3 inflammatory small body pathway; a reference basis is provided for treating the cow mastitis caused by streptococcus agalactiae infection by applying the baicalin.

The invention discloses a whitening and antibacterial knitted fabric and a preparation method thereof, and belongs to the technical field of functional clothing, Zn (NO3) 2.6 H2O and 1, 4-phthalic acid (H2BDC) are fully dissolved and dispersed through N, N-dimethylformamide (DMF) and dried to prepare Zn-BDC MOF powder, then nicotinamide and chitosan with whitening, spot fading and antibacterial functions pass through N, N-dimethylformamide (DMF) through interaction of subjects and guests, and the functional clothing is obtained. And dissolving N, N-dimethylformamide, and embedding into MOF pores to obtain the whitening skin-care antibacterial functional MOF material. And finally, adding a polyvinyl alcohol solution to obtain a functional finishing agent, and finishing the finishing agent on knitted garments to obtain the knitted fabric with the whitening, skin-care and antibacterial composite functions. The obtained knitted fabric has good whitening, skin care and antibacterial effects and can be applied to sportswear worn in daily life, and knitted garments made of the knitted fabric have the whitening and skin care effects, are good in use comfort and efficiently resist bacteria.

The invention discloses moisturizing, whitening and cutin-removing essence containing salicylic acid and a preparation method of the moisturizing, whitening and cutin-removing essence. The essence provided by the invention is prepared from the following components in percentage by mass: 0.5 to 2 percent of a skin conditioner I, 2 to 5 percent of a humectant I, 0.05 to 0.08 percent of a surfactant I, 0.05 to 1 percent of a humectant II, 0.2 to 1 percent of a humectant III, 0.3 to 0.5 percent of a surfactant II, 0.05 to 0.015 percent of a skin conditioner II, 0.05 to 0.015 percent of a skin conditioner III and the balance of water. The salicylic acid compound is introduced into the essence, so that the water solubility of salicylic acid is improved, the skin care effect of salicylic acid is facilitated, and the irritation caused by salicylic acid is reduced. Compared with the prior art, the moisturizing, whitening and cutin-removing essence containing salicylic acid prepared by the invention is safe and non-irritant, and has good moisturizing, whitening and cutin-removing effects.

The invention relates to combined lactobacillus salivarius LS100 for inhibiting vaginitis pathogenic bacteria and preventing and treating vaginitis and application of the combined lactobacillus salivarius LS100. The combined lactobacillus salivarius LS100 is preserved in the China General Microbiological Culture Collection Center (CGMCC), and the preservation number is CGMCC NO.32135. The combined lactobacillus salivarius LS100 has good hydrogen peroxide production capacity and adhesion capacity, and can be used for preparing medicines for preventing and treating vaginitis. The traditional Chinese medicine composition has a relatively strong inhibition effect on main vaginitis pathogenic bacteria, is effective on nutritional pathogenic bacteria, and can also reduce form transformation and biological membrane formation of the pathogenic bacteria and prevent generation of drug resistance; besides, the fermentation product can reduce the content of pathogenic bacteria metabolites, regulate the secretion of cell factors and play a role in relieving inflammation, so that the fermentation product can be used for preparing products for preventing and treating genital tract pathogenic bacteria infection and / or preventing and treating vaginitis.

The invention relates to an application of chrysin in preparation of drugs for treating mammalian NFAT2 related diseases. It is confirmed for the first time that chrysin shows significant anti-inflammatory activity in a KD mouse model and a cell injury model. This effect may be achieved by modulating NFAT2. The discovery has important significance for understanding and potentially treating the vascular endothelial injury of the Kawasaki disease, and a new insight is provided for treating the Kawasaki disease by using traditional Chinese medicines.

The invention discloses a strain of lactobacillus reuteri YSLR01 and application of the strain of lactobacillus reuteri YSLR01 in preparation of anti-inflammatory, anti-oxidation, fat-reducing and anti-aging products. According to the invention, a YSLR01 strain with anti-inflammatory, anti-oxidation, fat-reducing and anti-aging effects is separated from excrement of healthy human beings, the strain is preserved in China General Microbiological Culture Collection Center on September 2, 2024, and the preservation number is CGMCC NO.31800. The invention further discloses a preparation method of the YSLR01 strain. Researches show that the YSLR01 strain can significantly reduce secretion of inflammatory factors in a lipopolysaccharide (LPS)-induced RAW264.7 cell inflammation model, improve the oxidation resistance of caenorhabditis elegans, enhance the body length, action ability and reproductive capacity of the caenorhabditis elegans, reduce fat deposition in the body and delay aging of the body.

According to the probiotic composition and the application of the probiotic composition in preparation of products for preventing and treating vagina inflammation, the probiotic composition composed of lactobacillus gasseri B13.52 and lactobacillus mucus B14.46 screened from vaginal secretion of healthy women can effectively inhibit growth of escherichia coli, gardnerella and prevotella; the secretion of proinflammatory factors in vaginal epithelial cells can be obviously reduced, so that an anti-inflammatory effect is achieved.

The invention relates to a composition with effects of controlling oil and removing dandruff and application of the composition. The composition with the effects of controlling oil and removing dandruff comprises sophorolipid, myristicamidopropyl PG-dimethyl ammonium chloride phosphate, creatine, a phellinus linteus extract, a hop extract and sodium chloride. According to the composition, the sophorolipid, the myristicamidopropyl PG-dimethyl ammonium chloride phosphate, the creatine, the phellinus linteus extract, the humulus lupulus extract and the sodium chloride are matched for use, the synergistic interaction effect is achieved, the hair cleaning effect can be achieved, meanwhile, healthy water-oil balance is provided for scalp, and the hair care effect is achieved. The completeness of the scalp barrier is favorably kept, so that the sebum secretion of the scalp is better reduced, and the formation of dandruff is reduced.

The invention relates to plant-extracted anti-hair-loss hair-strengthening essence and a preparation method thereof, and belongs to the technical field of scalp care. The plant-extracted anti-hair loss and hair-strengthening essence is prepared from an anti-hair loss agent A, an anti-hair loss agent B, a composite conditioner, pyrrolidinyl diaminopyrimidine oxide, pyridoxine hydrochloride, dipotassium glycyrrhizinate, allantoin, ethanol, butanediol, a preservative and deionized water. Various plant extracts are added and cooperate with other components to jointly promote blood circulation, nourish scalp and stimulate hair follicle growth, meanwhile, the scalp environment is conditioned, nutrition is provided for scalp and hair roots, the hair roots are strengthened, and therefore the comprehensive effects of preventing hair loss and strengthening hair are achieved.

The invention relates to combined lactobacillus salivarius LS360 for preventing and / or improving female genital tract infection and application of the combined lactobacillus salivarius LS360. The combined lactobacillus salivarius LS360 is preserved in the China General Microbiological Culture Collection Center (CGMCC), the preservation number is CGMCC NO.32134, and the combined lactobacillus salivarius LS360 has good biological characteristics and endurance capacity and can be used for preventing and / or improving female genital tract infection. The traditional Chinese medicine composition has a relatively strong inhibition effect on main vaginitis pathogenic bacteria, is effective on nutritional pathogenic bacteria, and can also reduce form transformation and biological membrane formation of the nutritional pathogenic bacteria and prevent and treat drug resistance; besides, the bacterial strain and the fermentation product can also reduce the content of pathogenic bacteria metabolites, regulate the secretion of cell factors and play a role in relieving inflammation, so that the bacterial strain and the fermentation product can be used for preparing products for preventing and treating female genital tract pathogenic bacteria infection, preventing and treating vaginitis and / or removing pudendum peculiar smell.

The utility model discloses a medical delactation bra, and relates to the technical field of brassieres, the medical delactation bra comprises a bra main body, the bra main body is formed by mutually attaching a bra surface layer and a bra inner layer which are the same in shape, cup stickers are arranged between the bra surface layer and the bra inner layer, and mutually-communicated and mutually-independent cavities are arranged in the cup stickers; the cavities are filled with mirabilite particles, the bra surface layer is provided with a zipper, and cavity inlets are formed in the positions, facing the zipper, of the cups. According to the application, the interior of the bra main body is filled with the mirabilite particles, the mirabilite can reduce milk secretion and relieve breast distending pain during delactation, and meanwhile, the mirabilite also has relatively strong water absorption and can absorb part of milk and relieve the moist feeling when the bra is worn.

The invention provides a fusion protein with high repair capacity, a preparation method and application thereof, and belongs to the technical field of hybrid peptides. The amino acid sequence of the fusion protein is shown as SEQ ID NO.1; the fusion protein is obtained by sequentially connecting the following modules in series: a functional domain 1 of fibronectin, a hydrophilic region 1 of elastin, a functional domain 1 of mussel mucin, a hydrophilic region 2 of elastin, a functional domain 2 of fibronectin, a hydrophilic region 3 of elastin, a functional domain 2 of mussel mucin, a hydrophilic region 4 of elastin and an integrin binding region of elastin. The fusion protein of fibronectin, elastin and mussel mucin is constructed, and the nucleotide sequence of the fusion protein is optimized, so that the relative migration rate of keratinocytes can be obviously improved, the expression quantity of repair-related genes of HaCat cells can be improved, the secretion quantity of skin stimulating factors can be reduced, and the inhibition rate on hyaluronidase can be improved; the skin repairing and relieving capability is improved.

The present invention relates to a composition for lowering blood sugar, blood lipid and blood pressure and a preparation method thereof, belonging to the field of biotechnology, and the composition comprises a Cyclocarya paliurus flower extract, a chicken heart extract, a mandarin fish head extract and a Gracilaria extract; the Cyclocarya paliurus flower extract is obtained by enzymolysis of Cyclocarya paliurus flower by hemicellulase and bromelain, and then by ficin; the chicken heart extract is obtained by graded enzymolysis of chicken heart by pepsin and subtilisin; the mandarin fish head extract is obtained by fermenting mandarin fish head by Aspergillus niger, and then by trypsin; the Gracilaria extract is obtained by graded enzymolysis of Gracilaria by acid protease and trypsin. The composition has good effects of lowering blood sugar, blood lipid and blood pressure, can be used for preventing and treating cardiovascular and cerebrovascular diseases, softening blood vessels, improving microcirculation, reducing three high symptoms, and has no toxic side effects.

The application provides a hot liquid source quorum quenching strain Shiquan Haeyuan bacteria and application thereof, the strain screened can inhibit pathogenic bacteria and is used for preparing bacteriostatic drugs; the preservation number of the Shiquan Haeyuan bacteria screened is CCTCC NO: M 20251224.The application also provides an AHL degradation enzyme Aii937 protein separated from the YESM3 strain, characterized in that the amino acid sequence of the protein is SEQ ID NO: 2.The YESM3 strain of the application can block the QS path of pathogenic bacteria through AHL lactonase Aii937, reduce the secretion of virulence factors of pathogenic bacteria; the strain YESM3 has no pathogenicity.AHL lactonase does not have broad spectrum, has strong substrate specificity, and only degrades C6-HSL and 3OC-C 14 -HSL.

The present invention provides a novel secretion reducing agent and novel secretion reducing method for reducing extracellular vesicle secretion from cells. The extracellular vesicle secretion reducing agent of the present invention is characterized in that it contains an inhibitor of a serine synthesis pathway. The cells are, for example, cancer cells such as colorectal cancer cells, lung cancer cells, melanoma cells, breast cancer cells, pancreas cancer cells, and multiple myeloma cells.

This invention discloses a strain of *Lactobacillus salivarius* CCFM1332 with multi-target regulatory effects and its application in periodontitis, belonging to the field of microbial technology. This invention yields a strain of *Lactobacillus salivarius* CCFM1332, which not only has vaginal immunomodulatory effects but also alleviates periodontitis. Specifically, it can: promote the secretion of antimicrobial peptides by vaginal epithelial cells VK2 / E6E7; reduce the periodontal probing depth in rats with periodontitis; reduce the number of pathogenic bacteria in the oral cavity of rats with periodontitis; downregulate the levels of serum inflammatory factors IL-1β, IL-6, and IL-17A; and reduce alveolar bone loss in rats with periodontitis, effectively alleviating alveolar bone resorption in rats.

The invention belongs to the technical field of injection production processes, and particularly relates to a famotidine injection and a preparation method thereof. According to the famotidine injection disclosed by the invention, dendrobium nobile is fermented by using lactic acid bacteria ATCC 8008 and saccharomycetes ATCC 918, and chlorogenic acid and ilaprazole are added to prepare the famotidine injection. According to the method for fermenting by using the lactic acid bacteria ATCC 8008 and the saccharomycetes ATCC 918, not only can the curative effect of famotidine be improved, but also the effect of the dendrobium is enhanced due to the modification of the dendrobium, and more beneficial substances in the dendrobium are obtained. The Chinese yam and the lotus seeds used in the famotidine have good body building effects, have the advantages of tonifying the spleen and nourishing the stomach and can also enter the heart and the spleen, and the medicine effect of the prepared famotidine is enhanced. The famotidine prepared by the invention can be used for treating peptic ulcer, and has a great development prospect in the field of first aid.

The invention discloses an extraction and separation method of houttuynia cordata extract and its application. The extraction and separation method of houttuynia cordata extract comprises extracting houttuynia cordata with ethanol aqueous solution to obtain ethanol extract, recovering ethanol and concentrating, extracting with ethyl acetate, taking water phase to obtain ethyl acetate water part, and obtaining houttuynia cordata extract. The houttuynia cordata extract can be used to prepare drugs for preventing and treating chronic obstructive pulmonary disease, reduce the secretion of airway epithelial cell mucin MUC5AC, increase the activity of pulmonary microvascular endothelial cells, inhibit the apoptosis of pulmonary microvascular endothelial cells, reduce the number of lung tissue macrophages, and improve lung function.

The application provides application of alnus ketone in preparation of a medicine for preventing and / or treating ulcerative colitis, and belongs to the technical field of traditional Chinese medicines. The application research finds that alnus ketone can significantly reduce secretion of intestinal epithelial cell inflammatory factor IL-8, and has an anti-inflammatory effect. Animal experiments show that alnus ketone can reduce weight loss of mice caused by ulcerative colitis, reduce severity of occult blood, and reduce shortening of the colon, indicating that alnus ketone has a protective effect on ulcerative colitis. The alnus ketone is applied to clinical treatment, and has the advantages of high efficiency, low toxicity, economy and feasibility.

The application discloses an engineered exosome targeting human urokinase-type plasminogen activator receptor uPAR and a preparation method and application thereof. Firstly, a high-affinity anti-human uPAR single-domain antibody VHH is prepared; then, a human umbilical cord mesenchymal stem cell engineering cell line expressing a VHH-PTGFRN fusion protein is constructed, and the engineered exosome is prepared and purified by combining three-dimensional hypoxic culture, chemical induction and size-exclusion chromatography technology. The engineered exosome comprises four comparative samples, wherein the core sample Exo^(VHH / miR) can simultaneously display the anti-uPAR VHH on the membrane surface to realize targeted delivery and enrich miR-193b-3p in the chamber to realize gene silencing, and the synergistic effect of the two can efficiently remove the uPAR high-expression senescent cells and inhibit the senescence-associated secretory phenotype SASP. The engineered exosome has the advantages of standardized preparation process, high yield and high purity, strong targeting, excellent curative effect and good safety, and can be used for preparing a treatment preparation for anti-aging and aging-related diseases, and has important clinical application value.

The embodiment of the present application provides a coating and a preparation method thereof. In parts by weight, the coating includes 40 to 50 parts of modified epoxy acrylate, 10 to 15 parts of aromatic polyurethane acrylate, 16 to 36 parts of functional monomers, 3.2 to 5.4 parts of photoinitiators, and 5 to 10 parts of curing agents. Among them, the modified epoxy acrylate is adipic acid-modified epoxy acrylate, and the functional monomer includes at least one of dipropylene glycol diacrylate and tripropylene glycol diacrylate. By compounding these specific ratios of modified epoxy acrylate, aromatic polyurethane acrylate, functional monomer, photoinitiator and curing agent, the coating has a long activation period, low curing energy, good film toughness, good adhesion and good sealing effect on pine wood.

The invention discloses a bispecific antibody modified tumor cell-derived drug-loaded vesicle and a preparation. The tumor cell-derived drug-loaded vesicles comprise vesicles released by apoptotic tumor cells and antitumor drugs wrapped in the vesicles and used as effective components; the vesicles are modified with a bispecific antibody through DSPE-PEG-NH2, and the bispecific antibody can achieve a synergistic effect with an anti-tumor drug wrapped by the vesicles at a targeting part of the vesicles; the bispecific antibody is a PD-L1 / TGF (Transforming Growth Factor)-beta bispecific antibody. The tumor cell-derived drug-loaded vesicle provided by the invention can target tumor tissues, responds to release a bispecific antibody in a tumor subacid environment, and reduces tumor matrix components by regulating and controlling tumor-related fibroblasts, so that the enrichment and deep penetration of the drug-loaded vesicle at a tumor part are increased.

The invention discloses an improved oil-control moisturizing essential oil soap based on synergistic effect of Chinese herbal medicines and a preparation method thereof. The soap comprises 10% of winter mulberry leaf, 8% of motherwort, 6% of radix angelicae, 5% of ligusticum wallichii, 6% of bighead atractylodes rhizome, 7% of white poria, 4% of mung bean, 3% of ginseng, 2% of pearl, 18% of Chinese honeylocust fruit, 12% of castor oil and 12% of olive oil. The composition has the beneficial effects that the activity of 5alpha-reductase is inhibited by the flavonoid components of the winter mulberry leaves, and experiments show that the secretion amount of skin grease is reduced by 35% after the composition is used.

The invention relates to the technical field of biology, in particular to a method for intervening metabolism reprogramming of macrophages and application of the method. The invention provides a method for intervening metabolic reprogramming and inflammatory activation of macrophages, namely, by down-regulating the TRAF2 expression level of the macrophages, influencing the metabolic reprogramming of the macrophages and reducing the activation of an NLRP3 inflammatory small body pathway of the macrophages and the generation of inflammatory cytokines, the acute hepatic failure induced by LPS / D-GalN is relieved. Interference on metabolism reprogramming and inflammatory activation of macrophages based on the method is expected to be applied to intervention of other liver injuries related to macrophage homeostasis imbalance, including liver ischemia reperfusion injury, alcoholic liver injury, metabolic liver injury, autoimmune liver injury, hepatic failure and the like.

The invention discloses a traditional Chinese medicine formula for treating idiopathic pulmonary fibrosis and a preparation method of the traditional Chinese medicine formula, the traditional Chinese medicine formula consists of twelve raw material medicines in specific parts by weight: radix glehniae, radix ophiopogonis, astragalus membranaceus, codonopsis pilosula, selfheal, oyster, processed pinellia ternate, edible tulip, seaweed, concha meretricis seu cyclinae, rhizoma sparganii and curcuma zedoary. The composition can effectively inhibit fibroblast proliferation and activation and reduce extracellular matrix secretion, and can play an anti-fibrosis role by inhibiting TNF-alpha inflammatory factors and NF-kappa B signal pathways, clinical tests show that the composition can significantly improve clinical symptoms of patients and delay lung function decline, and is good in safety and suitable for clinical application. The invention also provides a preparation method of the composition, various dosage forms such as decoction, granules, freeze-dried powder and the like can be prepared, the preparation process is simple and convenient, the composition is suitable for industrial production, and a safe and effective new traditional Chinese medicine treatment choice is provided for idiopathic pulmonary fibrosis.