15results about How to "Reduce secretion" patented technology

The utility model discloses a medical delactation bra, and relates to the technical field of brassieres, the medical delactation bra comprises a bra main body, the bra main body is formed by mutually attaching a bra surface layer and a bra inner layer which are the same in shape, cup stickers are arranged between the bra surface layer and the bra inner layer, and mutually-communicated and mutually-independent cavities are arranged in the cup stickers; the cavities are filled with mirabilite particles, the bra surface layer is provided with a zipper, and cavity inlets are formed in the positions, facing the zipper, of the cups. According to the application, the interior of the bra main body is filled with the mirabilite particles, the mirabilite can reduce milk secretion and relieve breast distending pain during delactation, and meanwhile, the mirabilite also has relatively strong water absorption and can absorb part of milk and relieve the moist feeling when the bra is worn.

The application provides a hot liquid source quorum quenching strain Shiquan Haeyuan bacteria and application thereof, the strain screened can inhibit pathogenic bacteria and is used for preparing bacteriostatic drugs; the preservation number of the Shiquan Haeyuan bacteria screened is CCTCC NO: M 20251224.The application also provides an AHL degradation enzyme Aii937 protein separated from the YESM3 strain, characterized in that the amino acid sequence of the protein is SEQ ID NO: 2.The YESM3 strain of the application can block the QS path of pathogenic bacteria through AHL lactonase Aii937, reduce the secretion of virulence factors of pathogenic bacteria; the strain YESM3 has no pathogenicity.AHL lactonase does not have broad spectrum, has strong substrate specificity, and only degrades C6-HSL and 3OC-C 14 -HSL.

The application provides application of alnus ketone in preparation of a medicine for preventing and / or treating ulcerative colitis, and belongs to the technical field of traditional Chinese medicines. The application research finds that alnus ketone can significantly reduce secretion of intestinal epithelial cell inflammatory factor IL-8, and has an anti-inflammatory effect. Animal experiments show that alnus ketone can reduce weight loss of mice caused by ulcerative colitis, reduce severity of occult blood, and reduce shortening of the colon, indicating that alnus ketone has a protective effect on ulcerative colitis. The alnus ketone is applied to clinical treatment, and has the advantages of high efficiency, low toxicity, economy and feasibility.

The application discloses an engineered exosome targeting human urokinase-type plasminogen activator receptor uPAR and a preparation method and application thereof. Firstly, a high-affinity anti-human uPAR single-domain antibody VHH is prepared; then, a human umbilical cord mesenchymal stem cell engineering cell line expressing a VHH-PTGFRN fusion protein is constructed, and the engineered exosome is prepared and purified by combining three-dimensional hypoxic culture, chemical induction and size-exclusion chromatography technology. The engineered exosome comprises four comparative samples, wherein the core sample Exo^(VHH / miR) can simultaneously display the anti-uPAR VHH on the membrane surface to realize targeted delivery and enrich miR-193b-3p in the chamber to realize gene silencing, and the synergistic effect of the two can efficiently remove the uPAR high-expression senescent cells and inhibit the senescence-associated secretory phenotype SASP. The engineered exosome has the advantages of standardized preparation process, high yield and high purity, strong targeting, excellent curative effect and good safety, and can be used for preparing a treatment preparation for anti-aging and aging-related diseases, and has important clinical application value.

The invention discloses an improved oil-control moisturizing essential oil soap based on synergistic effect of Chinese herbal medicines and a preparation method thereof. The soap comprises 10% of winter mulberry leaf, 8% of motherwort, 6% of radix angelicae, 5% of ligusticum wallichii, 6% of bighead atractylodes rhizome, 7% of white poria, 4% of mung bean, 3% of ginseng, 2% of pearl, 18% of Chinese honeylocust fruit, 12% of castor oil and 12% of olive oil. The composition has the beneficial effects that the activity of 5alpha-reductase is inhibited by the flavonoid components of the winter mulberry leaves, and experiments show that the secretion amount of skin grease is reduced by 35% after the composition is used.

The invention discloses a traditional Chinese medicine formula for treating idiopathic pulmonary fibrosis and a preparation method of the traditional Chinese medicine formula, the traditional Chinese medicine formula consists of twelve raw material medicines in specific parts by weight: radix glehniae, radix ophiopogonis, astragalus membranaceus, codonopsis pilosula, selfheal, oyster, processed pinellia ternate, edible tulip, seaweed, concha meretricis seu cyclinae, rhizoma sparganii and curcuma zedoary. The composition can effectively inhibit fibroblast proliferation and activation and reduce extracellular matrix secretion, and can play an anti-fibrosis role by inhibiting TNF-alpha inflammatory factors and NF-kappa B signal pathways, clinical tests show that the composition can significantly improve clinical symptoms of patients and delay lung function decline, and is good in safety and suitable for clinical application. The invention also provides a preparation method of the composition, various dosage forms such as decoction, granules, freeze-dried powder and the like can be prepared, the preparation process is simple and convenient, the composition is suitable for industrial production, and a safe and effective new traditional Chinese medicine treatment choice is provided for idiopathic pulmonary fibrosis.

The invention discloses application of morin, and relates to the technical field of bacterial quorum sensing inhibition. The invention discloses application of morin in preparation of a medicine for reducing enterotoxigenic escherichia coli quorum sensing. Quorum sensing of enterotoxigenic escherichia coli can be reduced by using 5.0 mg / mL of Morrin, so that secretion of virulence factors of the enterotoxigenic escherichia coli is reduced. In the Escherichia coli treated by the Morin, the Morin has no obvious inhibition effect on the growth of the Escherichia coli, and the abundance of an autoinducer 2 (AI-2) and a quorum sensing related gene is obviously reduced, so that the toxicity and the adhesion capability of the Escherichia coli are reduced. The method for reducing enterotoxigenic Escherichia coli quorum sensing provided by the invention is beneficial to replacing traditional antibiotic in-vivo treatment and assists in resisting bacterial infection.

The present application relates to a kind of antiperspirant deodorant composition and its application in male antiperspirant deodorant product.The composition includes the following components: Sophora root extract, Oldenlandia diffusa extract, salvia extract, Hibiscus sabdariffa flower extract and Radix Ophiopogonis extract, the weight ratio of the Sophora root extract, Oldenlandia diffusa extract, salvia extract, Hibiscus sabdariffa flower extract and Radix Ophiopogonis extract is (0.05-2) :(0.01-1) :(0.01-1) :(0.005-2) :(0.01-1).The composition of the present application can achieve the purpose of deodorization from the two aspects of inhibition and bacteriostasis by reasonable collocation of the above ingredients, and specifically regulate the influence of androgen on sweating, more suitable for adding in male antiperspirant deodorant product.

This invention provides the application of wrinkled papaya polyphenols in the preparation of drugs for treating osteoarthritis. The wrinkled papaya polyphenols are used in the preparation of drugs that reduce the release of pro-inflammatory cytokines and the inflammatory mediator NO in primary chondrocytes, and / or reduce the mRNA expression of inflammation-related enzymes, and / or inhibit the phosphorylation of proteins related to the NF-κB signaling pathway. To test and clarify the anti-inflammatory effect of wrinkled papaya polyphenols, an ADTC5 primary chondrocyte inflammation model was constructed for observation. The results showed that wrinkled papaya polyphenols significantly inhibited IL-1β-induced inflammation in ADTC5 primary chondrocytes, effectively reduced the secretion of pro-inflammatory cytokines (IL-6 and TNF-α), inhibited the release of the inflammatory mediator NO, downregulated the mRNA expression of inflammatory enzymes (iNOS and Cox-2), and reduced the phosphorylation of IκBα and p65 proteins.

The invention provides a pramoxine hydrochloride and fluconazole combined pharmaceutical composition for resisting candida albicans biofilm infection and application of the pharmaceutical composition, and belongs to the technical field of biological medicine. Aiming at the problem of inherent drug resistance of a candida albicans biological membrane to azole drugs, drug relocation strategy screening finds that pramoxine hydrochloride can significantly enhance the inhibitory activity of fluconazole to the candida albicans biological membrane. The action mechanism is as follows: pramoxapine hydrochloride is specifically targeted to key protein mevalonate kinase in a farnesyl pyrophosphate synthesis route in candida albicans, biosynthesis of ubiquinone is inhibited, the active oxygen level of mitochondria is increased, the mitochondrial function is destroyed, the hypha length, the biological membrane thickness and extracellular matrix secretion of candida albicans are reduced, and the activity of pramoxapine hydrochloride in the candida albicans is improved. And finally, the anti-biofilm effect of fluconazole is improved. The invention provides a safe and efficient new strategy for resisting Candida albicans biofilm infection, and provides a new pharmaceutical composition and an action target for clinical treatment of biofilm related fungal infection.

This invention relates to the field of non-metallic mine backfilling technology, and particularly to a potash mine solid-liquid tailings-based backfill material and its preparation method. The preparation method of the backfill material includes: mixing potassium phosphate with tailings to obtain a phosphate brine solution; dry mixing composition 1 of a composite binder with the tailings to obtain a uniform dry material; adding the phosphate brine solution to obtain a uniform slurry 1; adding a mineral carrier-loaded slow-release alkali source to the uniform slurry 1 to obtain a uniform slurry 2; first adding a polycarboxylate superplasticizer to the uniform slurry 2 and mixing, then adding an associative thickener solution and mixing, and finally adding anionic polyacrylamide to obtain the backfill material. The backfill material prepared by this invention achieves a coordinated balance between slurry fluidity, anti-segregation, pumpability, and backfill strength, providing an economical, environmentally friendly, and efficient technical solution for backfilling non-metallic mine goaf areas.

This invention relates to the field of traditional Chinese medicine composition technology, and in particular to a ginseng-frog oil composition for reducing the dryness of ginseng and its application. The frog oil in the composition provided by this invention can significantly reduce the dryness caused by ginseng alone, specifically by reducing the levels of serum inflammatory factors (IL-6, TNF-α), malondialdehyde (MDA), and cortisol (CORT), increasing superoxide dismutase (SOD) activity, reducing saliva secretion, and decreasing animal thermoresponsiveness. This effectively solves the technical pain points of significant dryness caused by ginseng alone and its limited long-term application, achieving a "nourishing without drying" effect. The composition provided by this invention has high safety and reproducibility, consists of only two natural components, requires no additional excipients, and can be widely used in the preparation of mild tonic health products, pharmaceuticals, and functional foods, possessing good application prospects and promotional value.

This invention provides a method for regulating blood glucose responses between two consecutive meals by drinking a vinegar-containing beverage at different times. The method includes: drinking a sugar-vinegar aqueous solution with a sugar-acid ratio of 15:1 while consuming a high-carbohydrate diet; wherein the vinegar-containing beverage contains 0.8-1.2 g of acetic acid per serving, 12-18 g of available carbohydrates per serving, and 200 mL of liquid per serving; thereby reducing the area under the curve of post-meal blood glucose increase after the first meal, reducing the total insulin secretion after the first meal, and reducing the post-meal blood glucose load after the second meal. This invention provides, for the first time, human intervention data using traditional Chinese aged vinegar as the raw material and rice as the background of a high-carbohydrate diet, filling a gap in domestic research. Through randomized crossover self-controlled experiments, the specific effects of drinking different formulations of aged vinegar beverages with or before meals on blood glucose, insulin, and satiety between two consecutive meals were clarified.

The invention relates to application of GalNAc-Igf1r siRNA of a targeted silencing liver Igf1r gene in preparation of a medicine for treating skin injury, the siRNA of the targeted Igf1r is designed on the basis of the Igf1r gene, the siRNA is delivered into a living body through subcutaneous injection after GalNAc modification, the expression of the liver Igf1r gene is specifically silenced for a long time so as to inhibit an Insuin / IGF-1 signal channel, and the siRNA of the targeted silencing liver Igf1r gene can be used for treating skin injury. Regulation and control on skin injury healing are realized by regulating and controlling the circulating IGF-1 level, and an efficient gene therapy scheme is provided for promoting skin injury repair. According to the invention, GalNAc-Igf1r siRNA is specifically delivered to animal livers so as to discuss the influence of specifically silencing liver Igf1r genes on skin injury repair in a middle-aged state and a mechanism thereof, and a medicine for safely and efficiently promoting skin wound healing and barrier repair is provided.

The invention provides an oleanane triterpenoid compound as well as a separation method and application thereof, and relates to the technical field of traditional Chinese medicine separation. The oleanane type triterpenoid compound comprises four structures, and the oleanane type triterpenoid compound is obtained through petroleum ether extraction, silica gel column chromatography, reversed-phase column separation, gel column chromatography and high-performance liquid chromatography separation by taking tree leaves as a raw material. According to the invention, not only is the novel oleanane triterpenoid separated and extracted, but also an efficient separation and purification method is established, the anti-inflammatory activity of the obtained compound is remarkably superior to that of a positive drug, and the obtained compound has a good treatment window, provides a new candidate molecule for treatment of inflammatory diseases, and has remarkable social and economic benefits and a good application prospect.