The present invention discloses a scientific weight losing fully nutritional powder composition having satiety and belongs to the field of special dietary food processing. The composition is characterized by comprising the following components in percentages by mass: oat dietary fibers, plantago ovate seed shell powder, a garcinia cambogia fruit extract, a green coffee bean extract, sodium caseinate and mogrosides, and is also prepared by mixing the following raw materials: soybean protein isolate, plant fat powder, compound vitamins and compound minerals. By adding the oat dietary fibers, plantago ovate seed shells, sodium caseinate and mogrosides, the composition reaches effects of promoting satiety, moistening intestines and relaxing bowels. By adding the garcinia cambogia fruit extract and coffee bean extract, the composition has effects of inhibiting appetite and promoting fat metabolism. By adding the soybean protein isolate, plant fat powder, compound vitamins and compound minerals, the composition can supplement body with proteins, fats, vitamins and minerals, enables the body to reach purposes of being health and losing weight, and is especially suitable for populations with obesity and overweight.