255 results about "Photoaging" patented technology

The invention relates to a cosmetic or dermatological composition containing a carrier comprising at least one fatty phase characterized in that it contains at least one derivative or a mixture of derivatives of 1,7-diphenyl-3,5-heptanedione having a particular structure and at least one oil having, in its structure, at least one amide unit.The invention also relates to its uses in cosmetics and dermatology, in particular for preventing or combating the harmful effects of UV radiation and pollution on human keratinous materials, and more particularly for preventing and / or treating photoaging of the skin.The invention also relates to a method for solubilizing a derivative or a mixture of derivatives of 1,7-diphenyl-3,5-heptanedione having a particular structure with at least one oil having, in its structure, at least one amide unit.

A skin care composition is provided which preferably comprises a mixture of N-acetylcysteine and L-carnosine in combination with a cosmetic, dermatological or pharmaceutically acceptable carrier therefor. The composition may optionally be provided as a sunscreen formulation, and provides a method for the prevention, amelioration or treatment of pathological conditions of the skin, including, but not limited to, intrinsic or chronological aging, or aging due to sun damage (photoaging), and which conditions are caused by, or exacerbated by, oxidative stress, carbonyl stress, or a combination of both.

Dry powder foundation formulations that include a sustained-release salicylic acid composition, an effective, buffering amount of one or more salicylate ions, and one or more of zinc and titanium oxides, and pigments or colorants, are disclosed. The formulations provide both acne treatment and prevention, and sunblock protection. The formulation can also include other sunblocking or sunscreen agents to prevent photoaging and sunburn, such as avobenzone, and 3-benzophenone, and other cosmetically-acceptable active agents and excipients.

Human and mammalian skin undergoes a variety of changes associated with chronological aging. Various environmental factors, disease states and genetic disorders may accelerate both the appearance of aging skin and also the structural and functional changes associated with aging skin. Ultraviolet radiation from the sun is one of the classic known and well-defined means of accelerating or worsening the aging of the skin and this is frequently termed photoaging. Other environmental factors, such as oxidative stress, free radicals, environmental toxins such as ozone and cultural customs or habits such as tobacco smoking are other known probe accelerators in photo aging skin. A wide variety of other factors known and unknown contribute to accelerated or premature aging of the skin. This invention discusses methods where electromagnetic radiation, in particular, light, can be used to photobiomodulate the activity of living cells to delay, diminish, retard or even reverse the structural and functional effects of aging of the skin and other living cells and tissues. In particular methods described for improving the appearance, structure, function of aging skin, including up and down regulating the genotypic markers for the phenotype of aging skin.

The invention provides a nanometer composite modifier used for improving the weatherability of a powder dye. The nanometer composite modifier consists of a flatting agent, inorganic nanometer powder, an organic anti-aging addition agent and a powder dope basic resin. The nanometer composite modifier fully exerts the collaborative anti-aging effect of the organic anti-aging addition agent and the inorganic nanometer powder as well as improves the problem that the flatting agent is over-added which is easy to float on the surface of a paint film. The invention also provides a preparation method of the modifier. The method is simple in technique and low in cost. The master batches of the modifier can be used in the powder dope to improve the property for resisting the aging of ultraviolet light of the powder dope to a great extent; the flatting property of the paint film of the powder dope is also improved.

A pharmaceutical composition for treatment of skin aging including a pharmaceutically effective amount of estriol; a pharmaceutically effective amount of estradiol; a pharmaceutically effective amount of hyaluronic acid; a pharmaceutically effective amount of green tea extract; and a pharmaceutically acceptable carrier is provided. In some embodiments, the composition further includes ascorbic acid, date palm extract, or a combination thereof. Also disclosed is a method for treating symptoms of skin aging and photoaging by administering a pharmaceutical composition having estriol, estradiol, hyaluronic acid, green tea extract, a pharmaceutically acceptable carrier and optionally, ascorbic acid and date palm extract. A method of promoting urogenital function is likewise provided wherein a pharmaceutical composition having estriol, estradiol, hyaluronic acid, and green tea extract is applied intravaginally.

The invention provides a novel anti-skidding coating for a deck, which is composed of the following components in parts by weight: 30-45 parts of latex, 2-5 parts of film forming accessory ingredient, 15-25 parts of titanium pigment, 5-20 parts of filler, 0.2-1.0 part of wetting dispersant, 5-15 parts of anti-skidding agent, 0.1-0.5 part of de-foaming agent, 0.5-1.0 part of age inhibitor, 0.5-2.0 parts of thickening agent, 0.5-1.0 part of anti-mildew corrosion-protection agent, and 10-25 parts of water. The coating of the invention has very high wearing resistance and anti-skidding degree; the formed coat has good adhesive ability, wearing resistance, weather resistance, light-proof aging resistance, seawater resistance and salt mist resistance, wherein the artificial weathering aging test (ultraviolet UVB-313 resistance) is 4000 h, and the wearing resistance (1000g / 1000r) is not more than 30mg; the coating is applied to the corrosion prevention of the decks and the iron surfaces of the sea apparatus of boats and ocean platforms, wherein the decks and the iron surfaces require to have weather resistance, anti-skidding property, wearing resistance, and seawater corrosion resistance. The preparation method of the anti-skidding coating for the deck is simple in technology, low in cost and is performed without special apparatus.

Compounds of general formula (I): R1-Wn-Xm-AA1-AA2-AA3-AA4-AA5-AA6-Yp-Zq-R2; their stereoisomers, mixtures thereof and / or their cosmetically or pharmaceutically acceptable salts, cosmetic and / or pharmaceutical compositions which contain them and their use in medicine, and in processes of treatment and / or care of the skin, hair and / or mucous membranes, in particular in the aging and photoaging of the skin.

Methods of treatment or prevention of hyperproliferative diseases or pre-cancerous conditions affecting epithelial cells, such as psoriasis, vitiligo, atopic dermatitis, or hyperproliferative or UV-responsive dermatoses, hyperproliferative or allergically mediated diseases of other epithelia and methods for reducing photoaging, or oxidative stress or for prophylaxis against or reduction in the likelihood of the development of skin cancer, are disclosed.

Methods of using inhibitors of the CD2 / LFA-3 interaction in treating skin conditions characterized by increased T cell activation and abnormal antigen presentation in the dermis and epidermis in mammals, including humans. Such conditions include psoriasis, UV damage, e.g., photoaging, atopic dermatitis, cutaneous T cell lymphoma such as mycosis fungoides, allergic and irritant contact dermatitis, lichen planus, alopecia areata, pyoderma gangrenosum, vitiligo, ocular cicatricial pemphigoid, and urticaria.

Provided is a radiation-curable pressure-sensitive adhesive composition for optical members. When being cured (crosslinked), the radiation-curable pressure-sensitive adhesive composition can attain sufficient progression of crosslinking reaction, without suffering from the inhibition of reaction caused by excessive scavenging of free radicals. When used in bonding adherends, the radiation-curable pressure-sensitive adhesive composition exhibits excellent durability and light leak resistance even under high-temperature conditions or high-temperature and -humidity conditions, and further is inhibited from photoaging and thus prevents the occurrence of faults associated therewith. A radiation-curable pressure-sensitive adhesive composition for optical members, which comprises (A) a specific (meth)acrylic copolymer, (B) a radiation-curable acrylic compound having two (meth)acryloyl groups in the molecule, (C) a radiation-curable acrylic compound having 3 to 10 (meth)acryloyl groups in the molecule, (D) a hydrogen-abstraction type photopolymerization initiator, (E) an isocyanate-type crosslinking agent having two or more isocyanate groups in the molecule, and (F) a specific light stabilizer in specific amounts respectively.

The composition comprises of a component A selected from a hydroxylated derivative of benzoic acid or of cinamic acid, their esters, amides or salts, a glycoside of a hexose, and their mixtures; and a component B selected from quinic acid, shikimic acid, their alkaline metal or alkaline earth salts, their methyl esters, and mixtures of the same. This composition is suitable for protecting the skin against ultraviolet radiation coming from the sun or artificial sources, such as those used in phototherapy units and in sun tanning rooms. For application in the field of dermatology and nutrition, and, in particular, in the photoprotection of the skin and mucosa, photo-ageing and photocarcinogenesis, including protection of the immune system associated with the skin.

Methods of preventing photoaging and other types of sun damage by topically applying a composition containing a serine protease inhibitor or milk are provided. Pharmaceutical compositions comprising serine protease inhibitors or milk for the prevention of photoaging and other types of sun damage are also provided.

The invention provides a skin barrier repairing complex, facial cream and a preparation method therefor. The skin barrier repairing complex comprises a composition for repairing skin barrier, hydroxylasiaticoside, deacidified carnosine, a glycyrrhiza inflata root extract, a radix scutellariae extract and a hamamelis extract, wherein the composition for repairing skin barrier comprises sea fennelcallus culture filtrate, Ectoin and a hydrolyzed red alga extract. The skin barrier repairing complex can achieve triple effects of simultaneously repairing cutin barrier, repairing immunologic barrier and strengthening microbiologic barrier; and the facial cream prepared from the skin barrier repairing complex is obvious in repairing effect and can be used for effectively improving hydrature of skin, increasing the content of hyaluronic acid in the skin, improving photoaging, helping cell saccharification reversing and reducing fine grain area.

Human and mammalian skin undergoes a variety of changes associated with chronological aging. Various environmental factors, disease states and genetic disorders may accelerate both the appearance of aging skin and also the structural and functional changes associated with aging skin. Ultraviolet radiation from the sun is one of the classic known and well-defined means of accelerating or worsening the aging of the skin and this is frequently termed photoaging. Other environmental factors, such as oxidative stress, free radicals, environmental toxins such as ozone and cultural customs or habits such as tobacco smoking are other known probe accelerators in photo aging skin. A wide variety of other factors known and unknown contribute to accelerated or premature aging of the skin. This invention discusses methods where electromagnetic radiation, in particular, light, can be used to photobiomodulate the activity of living cells to delay, diminish, retard or even reverse the structural and functional effects of aging of the skin and other living cells and tissues. In particular methods described for improving the appearance, structure, function of aging skin, including up and down regulating the genotypic markers for the phenotype of aging skin.

The invention provides an ultraviolet radiation damage resistant complex of marine oligosaccharides and collagen peptides, which is prepared from marine oligosaccharides with antioxidant activity and tilapia mossambica fishskin collagen peptides with molecular weight of between 2,800 and 3,000 Da through compatibility. Chemical and pharmacological experiments prove that: compared with single components subjected to compatibility, the complex can inhibit the generation of oxygen radicals caused by ultraviolet radiation obviously and can enter skin cell mitochondria in a targeting mode to a greater degree to inhibit light aging, and has the obvious protective effect on skin injury caused by the ultraviolet radiation. The complex provides theoretic support for the development of natural oligosaccharide-peptide complex uvioresistant and mitochondrion targeting medicaments and the high-value utilization of mariculture industry.

Compounds of general formula (I): their stereoisomers, mixtures thereof and / or their cosmetically or pharmaceutically acceptable salts, cosmetic and / or pharmaceutical compositions which contain them and their use in medicine, and in the treatment and / or care of the skin, particularly in the aging and photoaging of the skin, and more particularly for the treatment and / or prevention of wrinkles and / or stretch marks.

The present invention relates generally to the use of vitamin B12 (cobalamin or cyanocobalamin) alone or in combination with other photoprotective agents, including specifically other vitamins such as vitamin B9 (folic acid or folate) and vitamin B3 (niacin or niacinamide), or any chemical derivative of these vitamins and their salts, as a filter to protect cells against the damaging effects of ultraviolet (UV) light. The invention is, in one aspect, a method of reducing the rate of UV damage to cells exposed to a UV light source, by treating the cells with the vitamin composition, either alone or in combination with other photoprotective agents. Other aspects of the invention are compositions comprising effective amounts of vitamin B12 alone or in combination with other photoprotective agents including vitamin B9 and vitamin B3 and a pharmaceutically-acceptable carrier, that are useful in protecting cells, particularly skin cells, against the burning, genotoxic (mutagenic and carcinogenic), immunosuppressive and photoaging effects of UV light, especially sunlight. The invention has application as a UV light filter in oral preparations including tablets and drinks, topical creams, lotions, sprays, wipes and cosmetics. The invention also has application as a medicinal treatment for dermatological conditions caused by exposure to sunlight, such as actinic keratoses, photodermatitis, photo-induced (discoid) lupus erythematosus and the photosensitizing effects of a variety of drugs used commonly in clinical practice (e.g. certain antihistamines, ACE inhibitors, and antibiotics such as tetracycline).

The present invention relates to a cosmetic, dietary supplement, or pharmaceutical composition for oral ingestion or topical application to the skin comprising effective amounts of a tocopherol quinone, tocopherol quinol, plastoquinol, menaquinol, or phylloquinol compound, or any combination thereof as a method for preventing free radical oxidation or preventing or treating environmental skin damage including photoaging, trauma, discoloration, dryness, thickness, elasticity, or wrinkles.

The invention relates to a light aging resistant photodiffusion polycarbonate composite material and a preparation method thereof. The composite material is prepared from the following raw materials in parts by weight: 700-900 parts of polycarbonate aggregate, 100-300 parts of polycarbonate powder, 0.5-5 parts of photodiffusion agent, 2-8 parts of light stabilizer, 1-5 parts of antioxidant and 0.5-2 parts of processing agent. The light aging resistant photodiffusion polycarbonate composite material is prepared from the raw materials in high-speed mixing, extruding and pelletizing manners. The light aging resistant photodiffusion polycarbonate composite material disclosed by the invention has the advantages of being good in processing formability, good in light aging resisting performance, good in light transmittance and haze, and the like.

A composition comprising cartilage extract, grape seed extract and tomato extract was found to have remarkable anti-oxidant effect and free-radical inhibition. The tomato extract comprises lycopene. The composition which comprises a hydrophilic antioxidant, a lipophilic (hydrophobic) antioxidant, and a cartilage extract dramatically increases collagen synthesis in the dermis. Furthermore, the composition lowers collagenase activity and levels of advanced glycation end products (AGE). The signs of ageing, such as photoageing due to exposure to UV radiation, are related to the levels of collagen syntheses and free-radical oxidation. Compositions of the invention are intended for the treatment of ageing skin and the delaying of the onset of the signs of ageing in healthy skin.

Oral and topical pharmaceutical compositions, kits and methods of treatment thereof for treating various skin disorder including acne, psoriasis, ichthyosis, photoaging, photodamaged skin, and, skin cancer. Exemplary vitamin D analogs as active pharmaceutical ingredients include 2-methylene-19-nor-20(S)-1α-hydroxy-bishomopregnacalciferol, 19-nor-26,27-dimethylene-20(S)-2-methylene-1α,25-dihydroxyvitamin D3, 2-methylene-1α,25-dihydroxy-(17E)-17(20)-dehydro-19-nor-vitamin D3, 2-methylene-19-nor-(24R)-1α,25-dihydroxyvitamin D2, 2-methylene-(20R,25S)-19,26-dinor-1α,25-dihydroxyvitamin D3, 2-methylene-19-nor-1α-hydroxy-pregnacalciferol, 1α-hydroxy-2-methylene-19-nor-homopregnacalciferol, (20R)-1α-hydroxy-2-methylene-19-nor-bishomopregnacalciferol, 2-methylene-19-nor-(20S)-1α-hydroxy-trishomopregnacalciferol, 2-methylene-23,23-difluoro-1α-hydroxy-19-nor-bishomopregnacalciferol, 2-methylene-(20S)-23,23-difluoro-1α-hydroxy-19-nor-bishomopregnancalciferol, (2-(3′hydroxypropyl-1′,2′-idene)-19,23,24-trinor-(20S)-1α-hydroxyvitamin D3, 2-methylene-18,19-dinor-(20S)-1α,25-dihydroxyvitamin D3, a stereoisomer thereof, a prodrug thereof in oral compositions, a salt thereof, and / or a solute thereof. Compounds that activate retinoic acid receptors, such as retinoyls and retinoyl esters, include 13-cis-retinoic acid, all-trans-retinoic acid, (2E,4E,6Z,8E)-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexeneyl)nona-2,4,6,8-tetraenoic acid, 9-(4-methoxy-2,3,6-trimethyl-phenyl)-3,7-dimethyl-nona-2,4,6,8-tetraenoic acid, 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-napthoic acid, 4-[1-(3,5,5,8,8-pentamethyl-tetralin-2-yl)ethenyl]benzoic acid, retinobenzoic acid, ethyl 6-[2-(4,4-dimethylthiochroman-6-yl)ethynyl]pyridine-3-carboxylate, retinoyl t-butyrate, retinoyl pinacol, retinoyl cholesterol, an isomer thereof, a prodrug thereof for oral compositions, an ester thereof, a salt thereof, and / or, a solute thereof. Combinations of such active ingredients demonstrate synergistic efficacy.

The invention relates to a skin care product with anti-blue light effect, wherein the skin care product comprises prebiotics, mung bean seed fermentation broth, water-locking magnet, carnosine, doublenanometer coenzyme Q10 and sunflower bud extract. When the skin care product is applied on the skin, and massage is used, the product increases the activity of cells in the skin layer, so as to enhance the filtering ability of skin to blue light, block the generation of infrared infrared blue light free radicals, reduce and prevent the damage of blue light to skin, prevent the loss of skin density caused by exposure to sunlight, promote the generation of skin collagen, maintain skin elasticity, protect skin and reduce photoaging. At the same time, sunflower bud extract can activate peroxidase-activated receptor (PPAR), PPAR has anti-apoptosis effect, can ensure enough living keratinocytes to participate in the reformation and migration of wound epidermis, so it has skin wound healing andanti-inflammatory effect.

The invention relates to a cosmetic composition in the technical field of daily chemical products, in particular to an anti-blue-light cosmetic composition and a preparation method thereof. The composition is mainly prepared from, by mass, 0.1-8 parts of a citrus extract, 0.1-4 parts of a lespedeza capitata leaf / stem extract, 0.1-4 parts of cerium oxide, 0.1-8 parts of a buddleja officinalis extract, 0.1-10 parts of a hedychium coronarium root extract and 0.1-8 parts of a rutin compound. The anti-blue-light cosmetic composition can brighten the skin, reduce the oxidative damage to the skin caused by blue light, increase the survival quantity of epidermal keratinocytes under the UV radiation, maintain the integrity of the skin function, reduce the chronic mild inflammation of light aging, and provide a skin protection effect by reducing free radicals produced by the induced oxidative stress, so that the generation amount of active oxygen ROS declines to improve local microcirculation and play a vasoconstriction role, thereby controlling the fatigue signs caused by direct blue light irradiation, keeping the skin in balance of circadian rhythms, and keeping the skin in a health status.

The invention relates to an ultraviolet aging test method for an asphalt material (including asphalt, asphalt mortar and an asphalt mixture) in a tension state. The ultraviolet aging test method comprises the following steps: selecting a light source for an ultraviolet aging simulation test, and determining the change of the irradiation intensity of the light source along with space and time; preparing samples of the asphalt material; carrying out an ultraviolet aging test on the asphalt material in the tension state, carrying out a subsequent performance test, and analyzing test results. By implementing the test method provided by the invention, a light aging process of an asphalt pavement under a traffic load and ultraviolet light irradiation can be well simulated; an ultraviolet light aging degree of the asphalt material can be comprehensively analyzed; the light aging rules of the asphalt material can be revealed. The test method is reasonable in design, and is detailed and specific.

The invention relates to a partition test method for the ultraviolet light aging intensity of asphalt, which comprises the following concrete steps of: determining to select two different types of ultraviolet (UV) light sources; according to the different ultraviolet light sources, determining the intensity of ultraviolet light by using a UV irradiation meter or UV energy meter, and respectively carrying out space distribution determination of UV light irradiation intensity; according to test required outdoor ultraviolet light irradiation requirements, converting the total effective time of outdoor ultraviolet light irradiation into the total effective time of indoor ultraviolet light irradiation; according to different ultraviolet light source types and the space distribution situation of determined ultraviolet light irradiation intensity, carrying out partition design on an asphalt aging disk; considering asphalt thermal-ageing test requirements in current test specifications and the design of the partition aging disk, putting forward an asphalt sample dosage preparation method for light aging tests; and after carrying out light aging indoor simulation test according to the steps, carrying out macro and micro performance tests on asphalt, and carrying out comprehensive analysis on the uvioresistant light aging performance of ultraviolet through integrating the test factors such as experimental temperature, ultraviolet light irradiation intensity, ultraviolet light irradiation time, and the like. The test method is reasonable in design, specific and detailed, simple and convenient in test operations.

Described are methods for treating hyperproliferative disorders, including cancers, by administering to the affected mammal (e.g., human) an effective amount of a composition comprising one or more oligonucleotides which share at least 33% but less than 100% nucleotide sequence identity with the human telomere overhang repeat. Methods of treatment or prevention of hyperproliferative diseases or pre-cancerous conditions affecting epithelial cells, such as psoriasis, atopic dermatitis, or hyperprolferative diseases of other epithelia and methods for reducing photoaging, or oxidative stress or for prophylaxis against or reduction in the likelihood of the development of skin cancer, are also disclosed. The compositions and methods are also useful to treating other cancers.

Short tri- and tetrapeptides according to the following Formula I Ar(CH2)mX1—X2—CO—X3—X4—X5-(Trp)n-NX6R are potent, selective agonists of melanocortin 1 receptor (MC1R). Provided herein are skin care compositions including Formula I peptide agonists of MC1R and methods of regulating a skin condition of a mammal that include applying to a treatment surface of the body a safe and effective amount of a skin care composition including a Formula I peptide. The peptides, skin care compositions, and skin care methods described herein are useful in regulating a skin condition of a mammal associated with exposure ultraviolet (UV) radiation, including sunburn, UV sensitivity, photoaging, and skin pigmentation, particularly in the absence of sun exposure.