150 results about "Photoaging" patented technology

The invention belongs to the field of daily chemicals, and provides a composition with a longevity gene activation effect, a product containing the composition and application of the composition, and the composition provided by the invention comprises hexapeptide, chlamydomonas and cornflower extract. The hexapeptide, the chlamydomonas nivalis and the cornflower extract are compounded for use, so that the expression of longevity genes KLOTHO and SIRT1 can be remarkably improved. Once the longevity gene serving as the upstream of a signal regulation pathway is activated, various downstream signal pathways can be regulated, such as inhibition of expression of inflammation-related genes, promotion of DNA repair, telomere homeostasis, gene expression of mitochondrial energy and the like, promotion of synthesis of collagen and the like, and finally, longevity of cells and improvement of skin phenotypes are promoted. The effects of resisting wrinkles, tightening and the like are achieved. Therefore, the composition provided by the invention can activate long-life gene expression and regulate and control multiple signal pathways, has potential effects of improving light aging, tightening and resisting wrinkles and the like, and is an anti-aging composition with great potential.

The invention discloses an application of 4 '-methylamine baicalein in preparation of an anti-photoaging product. Experimental results show that the 4 '-methylamine baicalein not only has very low toxicity to fibroblasts, but also can remarkably improve the multiplication capacity of the fibroblasts irradiated by the UVB and can remarkably inhibit senescence of the fibroblasts irradiated by the UVB, and the effect of the 4'-methylamine baicalein is remarkably superior to that of baicalein; therefore, at least one of 4 '-methylamine baicalein or pharmaceutically acceptable salts, tautomers, stereoisomers and precursor compounds thereof can be used as an active ingredient for preparing anti-photoaging products, and the compound has important significance and application value especially for solving the photoaging problem generated by UVB phototherapy.

The invention belongs to the technical field of optical beauty, and discloses a medical beauty device with an LED light source and a body beauty system based on phototherapy, and the method comprises the steps: collecting multi-source data for fusion, and generating a skin health map through an ICP registration algorithm; based on the skin health map, segmenting a high-tolerance area and a blood vessel dense area; distributing laser wavelength, energy density and cooling parameters for each area; the dynamic thresholds are adjusted in real time in a self-adaptive mode through the dynamic thresholds; determining and dividing risk grades through multi-parameter fusion, triggering a grading response mechanism, and generating dynamic energy configuration parameters and a safety control strategy; based on the three-dimensional point cloud coordinates and spatial constraint conditions, dynamically adjusting laser path planning through a path re-planning algorithm, and generating a phototherapy execution log; generating a curative effect evaluation report based on the phototherapy execution log, and constructing a photoaging risk map; and updating the energy rule base through a reinforcement learning algorithm, and determining parameters of a threshold value and a weight coefficient of a registration algorithm to form closed-loop optimization.

The invention discloses application of plant-derived extracellular vesicles in preparation of a product for preventing and treating photoaging and a topical application composition. Pseudo-ginseng is used as a raw material for extraction and purification of plant-derived extracellular vesicles, and results show that the pseudo-ginseng-derived extracellular vesicles can significantly treat or improve photoaging. The invention explores the practical application of the fresh pseudo-ginseng extracellular vesicles based on the traditional theory of traditional Chinese medicine, and clarifies the molecular mechanism of the pseudo-ginseng extracellular vesicles. In a word, the extracellular vesicles derived from pseudo-ginseng have a wide application prospect in treatment of skin aging.

The invention discloses an anti-radiation fabric and a preparation method thereof, and relates to the technical field of fabric preparation. When the anti-radiation fabric is prepared, bismuth powder is pre-modified with (3-chloropropyl) trimethoxysilane and then reacts with an anti-aging agent to prepare modified bismuth powder; the preparation method comprises the following steps: enabling 4-aminophenylethanol and 4-(2-ethoxyl) benzaldehyde to react to prepare a flame-retardant monomer, and then enabling the flame-retardant monomer to react with isophorone diisocyanate and 1, 4-butylene glycol to prepare polyurethane; the preparation method comprises the following steps: reacting dimethylallylamine with 1, 3-bis (chloromethyl)-1, 1, 3, 3-tetramethyldisiloxane to obtain an antibacterial cross-linking agent; the modified bismuth powder, N, N-dimethylformamide, polyurethane, an antibacterial cross-linking agent and benzoyl peroxide are mixed to prepare a polyurethane coating, the outer side surface of polyester base cloth is coated with the polyurethane coating, drying is conducted, and the anti-radiation coating fabric is prepared. The anti-radiation fabric prepared by the invention has good anti-radiation, anti-light aging, flame-retardant and antibacterial properties.

The invention discloses a drug-loaded polygonatum kingianum extracellular vesicle, a preparation method and an application of the drug-loaded polygonatum kingianum extracellular vesicle in preparation of an anti-photoaging product, and aims to provide a drug-loaded polygonatum kingianum extracellular vesicle which has relatively high encapsulation efficiency and drug loading rate and good stability and biocompatibility, can effectively treat skin UVB inflammation, solves the problem that a drug is insoluble in water, improves the curative effect, and can be used for preparing an anti-photoaging product and a preparation method of the drug-loaded polygonatum kingianum extracellular vesicle. According to the technical scheme, the drug-loaded polygonatum kingianum extracellular vesicles comprise the polygonatum kingianum extracellular vesicles and drug active components loaded in the polygonatum kingianum extracellular vesicles, and the drug-loaded polygonatum kingianum extracellular vesicles comprise the drug-loaded polygonatum kingianum extracellular vesicles and the drug active components loaded in the drug-loaded polygonatum kingianum extracellular vesicles. The pharmaceutical active component is at least one of resveratrol, glutathione, astaxanthin and vitamin C. The invention further discloses a preparation method of the pharmaceutical composition. The invention belongs to the technical field of biological medicine.

The invention discloses a cyclic peptide composition, a preparation method thereof and application of the cyclic peptide composition in preparation of medical products and / or cosmetics. The cyclic peptide composition comprises a cyclic peptide and 21-type collagen, wherein the amino acid sequence of the cyclic peptide is as shown in SEQ ID NO. 1; the amino acid sequence of the type 21 collagen is as shown in SEQ ID NO. 2. The cyclopeptide composition disclosed by the invention is used for preparing medical products and / or cosmetics for resisting light aging and resisting aging, especially light aging, and the cyclopeptide and the type 21 collagen have a synergistic effect, so that an unexpected synergistic effect is achieved.

The invention relates to the technical field of polyurethane coatings, and discloses an antibacterial waterborne polyurethane-chitosan compound, a preparation method thereof and a coating, the antibacterial waterborne polyurethane-chitosan compound comprises the following raw material components: chitosan, oligomeric polyol, diisocyanate, a chain extender, a cross-linking agent, a neutralizer, a catalyst and a modified compound, the modified compound comprises graphene oxide, nano titanium oxide, a sensitizing agent and a dispersing agent. In the technical scheme provided by the invention, the nano titanium oxide can play a role in coordination crosslinking among molecular chains and play a synergistic role with the dispersing agent, so that the dispersion uniformity of the modified compound in polyurethane is improved, and meanwhile, the nano titanium oxide can be used as a catalyst for photocatalytic oxidation reaction to oxidize bacteria and fungi, so that the antibacterial effect is realized; by adopting the sensitizer, the applicable light wavelength range when the nano titanium oxide plays a catalytic function can be expanded, the light aging effect of light on the polyurethane material is reduced, and the antibacterial effect of polyurethane is improved.

The present invention relates to a peptide having anti-aging activity and a composition for skin regeneration or suppressing skin aging, comprising the peptide as an active ingredient. The peptide according to the present invention, comprising an amino acid sequence of SEQ ID NO: 1, has anti-aging activity and thus can be used as a raw material for a cosmetic product for skin regeneration or suppressing skin aging or as a raw material for a pharmaceutical product for preventing, ameliorating, or treating photoaging.

The invention provides an in-vitro anti-saccharification effect evaluation method and application thereof, and belongs to the technical field of skin saccharification resistance. A photoaging fibroblast model is adopted, after induction of an inducer, anti-saccharification evaluation is carried out by detecting the contents of collagen and waveform protein after application of a substance to be detected, and it is proved that the anti-saccharification effect of the anti-saccharification substance in the cell model is consistent with the result in human body effect evaluation; the evaluation method can be applied to screening and evaluation of anti-skin saccharification substances.

The utility model relates to an automatic ultraviolet irradiation device for a cell photoaging model. The automatic ultraviolet irradiation device comprises a box body and a cabinet door hinged to the front surface of the box body, the ultraviolet irradiation mechanism is mounted in the box body; the controller is mounted on the front surface of the box body; the ultraviolet irradiation mechanism comprises rotating rods rotationally installed on the two sides of the inner wall of the box body, a driving motor is started to drive the rotating rods to rotate, the rotating rods drive discs to rotate, a plurality of lamp tubes between the two discs rotate, the damaged lamp tubes are rotated to the upper portion, the normally-used lamp tubes are located at the lower portion, and meanwhile the driving motor is started to drive the rotating rods to rotate. The two driving motors are synchronous motors and drive the driving gears to rotate, the surfaces of the driving gears are meshed with the rack parts, the protection plate is pushed to be located between the two discs, used lamp tubes are located below the protection plate, other unused lamp tubes are located above the protection plate, and the unused lamp tubes are protected.

The invention relates to a recombinant humanized collagen bionic microneedle for skin aging resistance, the microneedle comprises a needle tip, a base and a concave chamber, recombinant humanized collagen is loaded on the needle tip, the base and the concave chamber are made of hyaluronic acid, and the recombinant humanized collagen is uniformly distributed on the needle tip of the microneedle. Compared with a traditional smearing method and a conical microneedle, the bionic microneedle has a better anti-aging effect in a photoaging mouse model. The penetration depth of the micro-needle is obviously improved, and the solubility and the adhesiveness of the micro-needle are superior to those of the existing collagen micro-needle.

The invention discloses a sugar derivative of hydroxycinnamic acid as well as a preparation method and application thereof in cosmetics. Specifically, the invention provides a sugar derivative of hydroxycinnamic acid. The compound is shown as a formula I in the specification. Compared with original hydroxycinnamic acid, the sugar derivative of hydroxycinnamic acid has better water solubility and stability, and has one or more effects of oxidation resistance, whitening, soothing, moisturizing, ultraviolet absorption and the like; when the composition is applied to cosmetics, light aging damage of skin can be relieved, and skin color can be brightened; .

The invention discloses a preparation method of an anti-ultraviolet light absorption coating based on photoresist and nanocarbon, which comprises the following steps: using a nanocarbon material and photoresist as raw materials; the light absorption coating with low fluorescent background, low reflectivity and deep ultraviolet light aging resistance under the deep ultraviolet condition is obtained through the steps of preparing mixed turbid liquid, coating, pre-baking, removing photoresist through optical etching, removing residual photoresist, post-baking to form more holes and the like. When the low-background light absorption coating is applied to a deep ultraviolet fluorescence detector, compared with a traditional coating material of an organic adhesive and nanocarbon, the low-background light absorption coating provided by the invention has the advantages that the baseline of the detector is reduced by 67%, the baseline drift is reduced by 75%, and the baseline change degree under deep ultraviolet long-term aging is lower than 0.5%; the material shows excellent deep ultraviolet light aging resistance and extremely low fluorescence background, and can be applied to space telescopes, night vision devices, microscopes and various fluorescence detectors / sensors based on the characteristic of low reflectivity so as to obtain lower background and noise.

The utility model belongs to the field of packaging films, particularly relates to a heat-insulating aluminum foil packaging film for food packaging, and aims to solve the problems that the quality guarantee period of food is shortened and the freshness and the quality of the food are reduced as the food is easily affected by light aging and oxidative deterioration due to the fact that the conventional packaging film is lack of effective barrier to ultraviolet rays and oxygen. According to the scheme, the film comprises a supporting frame and a winding drum, the winding drum is wound with a film body, and the film body comprises an ultraviolet-proof layer, a waterproof layer, an oxygen barrier layer, a protective layer, an aluminum foil layer, a contact layer and an antibacterial layer; the cutting assembly is arranged on the supporting frame and used for facilitating segmented cutting of the film body. Through the arrangement of the ultraviolet-proof layer and the oxygen barrier layer, the protection performance of the heat insulation aluminum foil packaging film for food packaging is effectively improved, damage of ultraviolet rays to food can be blocked, oxygen permeation can be prevented, and therefore the shelf life of the food is prolonged, and the freshness and quality of the food are kept.

The application belongs to the technical field of optical beauty, and discloses a medical beauty device with an LED light source and a body beauty system based on light therapy, which comprises the following steps: collecting multi-source data fusion and generating a skin health atlas through an ICP registration algorithm; based on the skin health atlas, a high tolerance area and a dense blood vessel area are segmented; laser wavelength, energy density and cooling parameters are allocated to each area; each dynamic threshold is adjusted in real time through a dynamic threshold; a risk level is determined and divided through multi-parameter fusion, and a hierarchical response mechanism is triggered to generate dynamic energy configuration parameters and safety control strategies; based on three-dimensional point cloud coordinates and space constraint conditions, a laser path planning is dynamically adjusted through a path re-planning algorithm to generate a light therapy execution log; based on the light therapy execution log, an efficacy evaluation report is generated to construct a photoaging risk atlas; through a reinforcement learning algorithm, the energy rule library, the parameters of the determination threshold and the weight coefficient of the registration algorithm are updated to form a closed-loop optimization.

The invention discloses an anti-aging Chinese medicine composition, which is composed of the following components by weight: 10-50 parts of snow lotus extract, 10-50 parts of motherwort extract, and 10-50 parts of tribulus terrestris extract. The anti-aging Chinese medicine composition of the invention is added to cosmetics as an anti-aging ingredient to prepare an anti-aging cosmetic stock solution. The anti-aging Chinese medicine composition of the invention is a pure natural Chinese medicine extract, and various components are mutually harmonized to exert a synergistic effect, and has excellent anti-aging effects, which are mainly manifested in anti-oxidation, mite inhibition, antibacterial and anti-photoaging. In addition, the Chinese medicine composition of the invention has low irritation to the skin, is safe and reliable, is a better cosmetic functional ingredient, and can be used to prepare anti-aging cosmetics.

The application discloses a ginseng polysaccharide, a preparation method and application, and the ginseng polysaccharide is ginseng polysaccharide GP60, which is composed of glucose, galactose and arabinose, and the molar ratio of each monosaccharide is glucose: galactose: arabinose = 77.1: 16.8: 6.1; a new preparation method is adopted; after soaking and twice decocting, different proportions of 95% ethanol are added into the filtrate in batches; the obtained precipitate is added with water to prepare a solution with a relative density of 1.1 g / ml; a certain amount of the solution is taken, a certain proportion of chloroform and n-butanol is added, and a polysaccharide aqueous solution is prepared; the polysaccharide aqueous solution is added with 95% ethanol until the alcohol content reaches 60%; the solution is statically placed for 12 hours; centrifugal separation is carried out; the precipitate is collected; the collected precipitate is sequentially washed with 95% ethanol, anhydrous ethanol, isopropyl alcohol and ether; the solvent is volatilized; and the ginseng polysaccharide GP60 is obtained. The ginseng polysaccharide GP60 is non-toxic, has the effect of preventing light aging, and can be widely applied in the fields of food or health food, anti-light aging skin care products, washing and caring products and anti-light aging medicines.

This invention provides an application of a quantitative partial reprogramming system in the preparation of drugs to reverse skin aging, belonging to the fields of regenerative medicine and medical aesthetics. The quantitative partial reprogramming system includes a nucleic acid delivery system or a small molecule induction system; skin aging includes photoaging-induced skin aging; reversing skin aging includes increasing the thickness of the dermis, increasing the density of type I collagen, and improving skin elasticity. The quantitative partial reprogramming system provided by this invention can fundamentally reverse the cellular aging clock and achieve structural regeneration, and can be applied to the preparation of drugs to reverse skin aging.

The application discloses application of plant-derived extracellular vesicles in preparation of products for preventing and treating photoaging and a local application composition. The application takes Panax notoginseng as raw material to extract and purify the plant-derived extracellular vesicles, and the results show that the extracellular vesicles derived from Panax notoginseng can significantly treat or improve photoaging. The application explores the practical application of extracellular vesicles of fresh Panax notoginseng based on traditional Chinese medicine theory, and clarifies the molecular mechanism of the extracellular vesicles. In general, the extracellular vesicles derived from Panax notoginseng have wide application prospects in treatment of skin aging.

The invention provides a nano-emulsion composition, a nano skin care product, a preparation method and application, the nano-emulsion composition comprises a nano-emulsion and nucleic acid loaded on the surface of the nano-emulsion, and the nano-emulsion comprises a functional component, an emulsifier, an emollient, an antioxidant, a humectant and water; the functional component comprises a barrier repair lipid, the barrier repair lipid comprises sphingolipid, the sphingolipid comprises phytosphingosine, and the barrier repair lipid further comprises one or more of ceramide, free fatty acid and cholesterol; the mass ratio of the nucleic acid in the nanoemulsion composition is 0.1%-0.6%. The nanoemulsion composition has excellent permeability, so that the skin permeability of the nucleic acid is improved, and the bioavailability of the nucleic acid is improved; meanwhile, the nucleic acid can be specifically bound with adenosine A2A receptors distributed on keratinocytes, so that the binding speed of the nano-emulsion and the cells can be increased, the absorption and action effects of the nano-emulsion are specifically promoted, and the resistance of the skin to light aging is improved.

The invention discloses a PPR weather-resistant antibacterial pipe and a preparation method thereof, the finished product PPR weather-resistant antibacterial pipe is obtained by mixing, extrusion granulation, pipe extrusion molding, outer wall wiping and drying, annular spraying and drying, traction and cutting, and a weather-resistant agent of a pipe body is a compound of a hindered amine light stabilizer and an antioxidant. Carbon black dispersion liquid is sprayed to the outer wall of the pipe through the annular spraying mechanism to form a weather-proof coating, carbon black forms a physical barrier on the surface of the pipe by means of the excellent ultraviolet absorption capacity, direct irradiation of ultraviolet rays to the pipe body is further blocked, inner and outer synergistic dual weather-proof protection is formed with a weather-proof system in the pipe body, the light aging rate is greatly reduced, and the service life of the pipe body is prolonged. The antibacterial agent is a compound of a quaternary ammonium salt organic matter and a silver-zinc compound inorganic matter, according to the pipe, through the synergistic effect of an antibacterial agent compound system, the antibacterial spectrum is widened, the antibacterial durability is improved, and meanwhile the excellent aging resistance and mechanical performance are kept.

The application belongs to the technical field of cosmetics, and particularly relates to a maleic acid and ectoine co-crystal as well as a preparation method and application thereof. The application comprises the following steps: mixing maleic acid and ectoine, and adopting a wet grinding process to obtain a maleic acid and ectoine co-crystal; and the molar ratio of the maleic acid and the ectoine is (0.8-1.2):(0.8-1.2). The maleic acid and ectoine co-crystal composition is prepared by the wet grinding method. The maleic acid and ectoine co-crystal can significantly improve the tensile strength of oxidatively damaged hair, and significantly repair the oxidatively damaged hair; and the content of hair ROS caused by photoaging is significantly reduced, and the maleic acid and ectoine co-crystal has a strong anti-photoaging effect. Meanwhile, the co-crystal preparation method is simple, has good repeatability, and is suitable for industrial production.

The invention belongs to the field of surface coating materials, and relates to a hardening liquid composition. The ultraviolet curing hardening liquid composition contains a photopolymerizable and surface-enriched ultraviolet light absorber A, a polyfunctional group acrylate prepolymer, a polyfunctional group acrylate monomer, a photoinitiator, a free radical scavenger and a solvent. The invention also comprises application of the hardening liquid composition in surface coatings of automobile exterior decorations, solar panels, building window films, optical films, automobile lamps, 3C products and the like. The hardening liquid composition can be coated on a substrate. A cured paint film has excellent adhesive force on a plastic base material and outstanding pencil hardness and wear resistance, and compared with a conventional hardened coating, the light aging resistance is improved by more than 5 times.

This application belongs to the field of microbial technology, and mainly relates to a strain of *Pediococcus lactis* BPA03 and its applications. *Pediococcus lactis* BPA03 is classified and named *Pediococcus lactis*. Pediococcus acidilactici This *Pediococcus lactis* strain BPA03 was deposited on September 28, 2025, at the China General Microbiological Culture Collection Center (CGMCC), located at No. 3, Courtyard 1, Beichen West Road, Chaoyang District, Beijing, with accession number CGMCC No. 36109. It inhibits skin melanin deposition and improves UV photoaging, suppresses the gene expression levels of immune factors such as IL-1β, IL-6, IL-8, and TNF-α, improves the activities of superoxide dismutase, catalase, and glutathione peroxidase, inhibits vinorelbine-induced neutropenia, and improves the inhibition of immune factor expression induced by vinorelbine, thus exhibiting comprehensive anti-aging effects.

The present application provides a peptide having the formula (I) R1-Ser-Pro-X1-Gln-R2 or a cosmetically or pharmaceutically acceptable salt thereof, or a cosmetic or pharmaceutical composition thereof, and their use in the preparation of a cosmetic or pharmaceutical composition for treating, preventing or repairing skin aging or photoaging, promoting collagen production, increasing skin elasticity and / or skin firmness, promoting PER1 protein expression, regulating skin circadian rhythm and / or repairing damaged skin cells. The peptide of formula (I) regulates the expression of skin circadian cycle regulation genes and related proteins, regulates skin circadian rhythm and resynchronizes skin cell biological clock, enhances cell vitality, repairs damaged cells, thereby alleviating signs of skin aging, and can be used in the field of cosmetics or medicine to resist skin aging, and can also be used to prepare a PER1 protein activator.

Pharmaceutical compositions for treating acne, photoaging, and uneven pigmentation comprising two or three distinct pharmaceutical ingredients are described. Methods for the treatment of acne, photoaging, and uneven pigmentation using the compositions are also described.

This application relates to the field of cosmetic technology, specifically disclosing an anti-photoaging skincare composition suitable for sensitive skin and its application. This application uses camellia flower extract, butcher's broom root extract, saffron extract, and lactobacillus fermentation products to form an anti-photoaging skincare composition. These components work together and inextricably on the coherent biological axis of skin microecological regulation – enhanced bioelectrical signals – activation of mitochondrial function. By restoring the core energy metabolism of skin cells, it fundamentally reverses the photoaging process and simultaneously achieves comprehensive rejuvenation effects such as anti-wrinkle, firming, and brightening.

The invention provides a synthetic method and application of silk fibroin-based melanin-like nanoparticles, and belongs to the technical field of nanoparticle preparations for biomedicine. After the silk fibroin nanoparticles, tyrosine and a tyrosinase solution are mixed, the silk fibroin-based melanin-like nanoparticles are obtained through a one-pot copolymerization reaction, and the enzyme concentration in the tyrosinase solution is 200-250 U / mL. The synthesis method has the advantages of being simple and convenient to operate, green, environmentally friendly and the like, and the synthesized silk fibroin-based melanin-like nanoparticles have excellent antioxidant activity and ultraviolet protection performance and remarkable skin cell photoaging resistance.

The present application relates to a kind of degradable PA6 composite modified plastics, belong to composite material technical field;The present application is by preparing a modifier with double bond in structure, and using the modifier to modify PBAT, effectively solve the uneven distribution problem of polar additive in PBAT-PA6 composite plastics, and provide good antibacterial performance and ultraviolet light aging resistance for composite plastics, in addition, the modifier of the present application can also improve the polarity of modified PBAT, and using the ionic-dipole interaction of quaternary ammonium salt structure in structure and the polar amide bond in PA6 is formed, the adhesion between modified PBAT phase and PA6 phase is enhanced, the compatibility between modified PBAT and PA6 is improved, and then the mechanical properties of PBAT-PA6 composite plastics as a whole is improved.