4 results about "Estriol" patented technology

The invention belongs to the technical field of immunodetection, and particularly relates to a specific binding antibody of estradiol as well as a preparation method and application of the specific binding antibody. The present application provides a specific binding antibody against estradiol (E2). The binding protein adopts rational design guided by computational simulation, the complementary determining regions (CDRs) of the binding protein are accurately optimized, the binding protein can target an estradiol characteristic structural domain with high affinity, structural analogues such as oestrone, estriol and corticoid can be effectively distinguished, and the binding protein shows excellent specificity. When being applied to the development of an in-vitro diagnostic kit, the aptamer can realize high-sensitivity and high-specificity quantitative detection of estradiol in a clinical serum sample, and a reliable tool is provided for precise diagnosis and treatment of related diseases.

This invention relates to the field of water treatment technology and discloses an intermittent electrocatalytic treatment method for trace estrogen in reclaimed water. The method is carried out in a three-dimensional electrode reactor. Before formal treatment, a pre-treated water sample containing the estrogen to be removed is used to pre-saturate the particle electrode. Subsequently, reclaimed water containing one or more estrogenic pollutants is continuously introduced into the reactor, operating at a current density of 1.0–10.0 mA / cm², a hydraulic retention time of 5–20 min, and an aeration rate of 0–3.0 L / min. An intermittent power supply mode with alternating power on and off is employed, wherein the ratio of power on time to power off time is 1:1, and the power off time is 2–120 s. During the power off phase, the estrogen to be removed accumulates on the surface of the particle electrode. During the power on phase, the particle electrode repolarizes to form a micro-battery and undergoes electrochemical oxidation in conjunction with the anode, causing direct oxidation and / or indirect oxidation mediated by an electrogenerated oxidant, while the particle electrode achieves in-situ regeneration. The method is applicable to the treatment of trace amounts of estrogens in reclaimed water, preferably one or more of estrone (E1), 17β-estradiol (E2), estriol (E3), 17α-ethinylestradiol (EE2), and bisphenol A (BPA). This invention can reduce the artificially inflated impact of adsorption on the evaluation of treatment effectiveness, and reduce energy consumption while ensuring treatment efficiency.

Disclosed is a vaginal ring delivering estriol. The ring is suitable for use in the treatment of vaginal and vulva atrophy. It has a core-shell structure of ethylene vinyl acetate copolymers. Both the core and the shell are loaded with estriol, with the concentration of estriol in the core exceeding that in the shell. The core and shell have a different copolymer composition, with the vinyl acetate in the core being higher than that in the shell.

The invention belongs to the technical field of steroid drug molecules, and relates to an estrone purification method, which comprises the following steps: adding 1, 4-diazabicyclo [2.2. 2] octane into a solution containing an estrone crude product and a first solvent to obtain a precipitate, dissolving the precipitate in a second solvent, adjusting to be alkaline, filtering, collecting filtrate, adjusting the pH value of the filtrate to be less than or equal to 3, and filtering to obtain the estrone purification product. And extracting with a third solvent to obtain an organic phase, cooling, crystallizing, carrying out suction filtration, and drying to obtain refined estrone. According to the method, the problem of removal of methylation rearrangement impurities generated in the existing preparation technology of the estrone is solved, the methylation rearrangement impurities can be purified from 0.7%-1.5% to less than or equal to 0.10% at a time, the purity of the finally obtained estrone is greater than or equal to 99.8%, and the yield is stable. The method disclosed by the invention is green and environment-friendly, low in cost, less in material loss, good in purification effect and stable in process, and has extremely high industrial application value.