19 results about "Vaginal ring" patented technology

A vaginal drug delivery and / or sensor device is provided comprising a drug delivery unit and / or sensing unit and a flexible circuit board comprising a first and second area preferably connected via one bent area. Control circuitry is arranged on the first area of the FPCB. A wireless communication module is arranged on the FPCB, and a slot antenna is formed on the second area of the FPCB by providing a slot in a metal layer arranged on the second area. A microstrip line connects the wireless communication module to a connection point at or adjacent to a first end of the slot. A ceramic buffer is arranged over the slot antenna on the second area. At least one adhesive layer is arranged between the ceramic buffer and the slot antenna on the second area.

The invention relates to the technical field of biology, in particular to leukocyte esterase detection test paper and a preparation method thereof. Based on the principle of a substrate and a color developing agent, the color developing depth is in direct proportion to the concentration of the esterase, so that the concentration of the leukocyte esterase in a detection sample can be judged according to the color developing depth; meanwhile, under the auxiliary action of calcium chloride and other materials, the detection distinction degree, the detection accuracy and the detection result stability are further improved. The leukocyte esterase test paper provided by the invention is simple in sample detection method, more stable in product performance, longer in validity period and wide in application range, can be used as an auxiliary evaluation index for vagina inflammation, and is combined with a cleanliness index and the like to jointly evaluate the vagina environment.

The present invention relates to an intravaginal ring (1) a core (2) comprising a first ethylene-vinyl acetate copolymer (3) having a vinyl acetate content from 28 to 40 wt %, and at least 10 wt % of an estrogenic steroid (4) based on the weight of the core, and a sheath (5) comprising a second ethylenevinyl acetate copolymer (6) having a vinyl acetate content from 18 to 28 wt %, and at least 10 wt % of a progestational steroid (7) based on the weight of the sheath. Using the intravaginal ring according to the present the inventors have found that it is possible to attain independent and optimal release of the two active ingredients: an estrogenic steroid and a progestational steroid, without the need for complex assembly of parts and without the need to use sophisticated multi-layer extrusion technology.

The present invention relates to levonorgestrel for use in a method for providing contraception in a female subject, comprising continuous intravaginal administration of levonorgestrel of from about 60 µg / day to about 100 µg / day. The invention further relates to levonorgestrel for use in a method for treating endometriosis, endometriosis associated pelvic pain (EAPP) and / or dysmenorrhea comprising continuously administering about 60 µg / day to about 160 µg / day of levonorgestrel. Delivery devices, preferably, intravaginal rings for putting the methods in practice are also envisaged.

A method of producing a structure, as well as the structure produced according to the method. The method includes steps of defining an outer surface of the structure, an internal volume of the structure being defined within the outer surface; defining, within the internal volume of the structure, one or more cores; selecting a unit cell geometry; and radially arraying unit cells around a perimeter of and / or within the internal volume of the structure to form a plurality of such unit cells that extend between the one or more cores and the perimeter, within the internal volume of the structure. The structures can be produced via additive manufacturing and loaded with one or more therapeutic compounds for use as medical devices. An example of such a medical device is an intravaginal ring (IVR) or a subcutaneous rod-shaped implant device.

The present application belongs to the technical field of artificial semen collection devices for sheep, and particularly relates to a sheep bionic semen collection device; the device comprises a silica gel heat storage liquid bag false vagina, a disposable semen collection inner membrane bag, a heat preservation roll and a columnar stimulation convex, the silica gel heat storage liquid bag false vagina comprises a silica gel column, a non-linear pipeline and a heat storage liquid bag, the heat storage liquid bag is filled with phase change heat storage liquid, and the non-linear pipeline penetrates the central axis of the silica gel column; the present application simulates the vaginal environment through folds, improves the simulation effect of the vagina, stores and releases heat by using the phase change heat storage liquid, is conducive to keeping the temperature of the sheep bionic semen collection device constant, according to the thermal expansion and cold contraction characteristics of the phase change heat storage liquid, squeezes the non-linear pipeline, realizes moderate tension of the false vagina, does not need to add water and pressure, is conducive to improving the success rate of semen collection, through the disposable semen collection inner membrane bag, the silica gel bionic vagina is exempted from decontamination, through the columnar stimulation convex, it is helpful for the ram to release semen, and the semen collection effect is improved.

In some example embodiments, there is provided a pessary apparatus configured to alleviate pelvic organ prolapse and urinary incontinence. This pessary may a urethral support knob having a first opening and a second opening; a cylindrical stem having a proximate end, a distal end, an exterior surface, and an interior surface that forms a hollow interior of the cylindrical stem, wherein the proximate end is coupled to the second opening of the urethral support knob; and a pessary. Related apparatus, systems, methods, and / or articles of manufacture are also disclosed.

The present invention relates to levonorgestrel for use in a method of providing contraception to a female subject comprising a sustained intravaginal administration of levonorgestrel of about 60-100 [mu] g / day. The invention further relates to levonorgestrel for use in a method of treating endometriosis, endometriosis-associated pelvic pain (EAPP) and / or dysmenorrhea, comprising a sustained administration of levonorgestrel of about 60-160 [mu] g / day. Dosing devices, preferably vaginal rings, for carrying out these methods are also contemplated.

The present disclosure relates to a multi-component intravaginal ring (IVR) for improved release of non-hormonal agents that can be used in a multi-purpose prophylactic technology (MPT) that simultaneously prevents accidental pregnancy and prevents or treats sexually transmitted infections (STIs) while optimizing vaginal health.

The invention discloses a female bacteriostatic device, and relates to the technical field of bacteriostatic compositions and bacteriostasis. The device comprises an LED light source, a micro liquid pump and a liquid storage bin, wherein a bacteriostatic composition contained in the liquid storage bin comprises epsilon-polylysine, vitamin B, sodium lignin sulfonate, a zein and hydroxypropyl trimethyl ammonium chloride chitosan compound, calcium peroxide and the like. The composition is prepared into freeze-dried gel through a freeze-drying process, when in use, the freeze-dried gel is redissolved to form a gel state, and the antibacterial effect is enhanced through irradiation of an LED light source. The problem that vitamin B is easy to decompose in the vagina environment is effectively solved, the stability and sterilization efficiency of antibacterial components are improved, and the composition is suitable for prevention and treatment of vulvovaginal candiditis and multi-bacterial mixed vaginitis.

Provided is an agent for improving the balance of normal vaginal microbiota that is effective in keeping a favorable vaginal state. The present invention provides an agent for improving the balance of normal vaginal microbiota using sophorose and / or laminaribiose. Sophorose and / or laminaribiose have functionality for promoting the growth of beneficial bacteria that have a beneficial vaginal effect while suppressing the growth of bacteria that have the possibility of causing an adverse vaginal effect among normal vaginal microbiota. This agent for improving the balance of normal vaginal microbiota can be suitably used for the purpose of keeping a favorable vaginal state while maintaining the balance of normal vaginal microbiota.

Disclosed is a vaginal ring delivering estriol. The ring is suitable for use in the treatment of vaginal and vulva atrophy. It has a core-shell structure of ethylene vinyl acetate copolymers. Both the core and the shell are loaded with estriol, with the concentration of estriol in the core exceeding that in the shell. The core and shell have a different copolymer composition, with the vinyl acetate in the core being higher than that in the shell.

The invention relates to the technical field of antibacterial gels, and discloses a vagina internal environment-imitating antibacterial gel, which is prepared by the following steps: S1, sufficiently swelling a phase A for later use at normal temperature; s2, fully dissolving the phase B, adding the phase A, and uniformly stirring; and S3, fully stirring and dissolving the phase C, the phase D and the phase E, adding the mixed phase in the S2, stirring, uniformly stirring, standing or defoaming under negative pressure, and filling. The radix sophorae flavescentis extract has the effects of resisting bacteria, diminishing inflammation, relieving itching, easing pain and improving the vaginal environment on the vagina, the peony root bark extract has the effects of resisting inflammation, resisting oxidation and improving skin health on the vagina, and the fructus cnidii extract can relieve pudendum wet itching and the like on the vagina; chitosan contained in the quaternized amino acid has the effects of promoting healing of the vagina and improving the vagina environment, meanwhile, the chitosan and quaternary ammonium salt in the quaternized amino acid jointly have the sterilization effect, and an amino acid group in the quaternized amino acid has the moisturizing effect.

The pregnancy assisting device comprises a piston and a piston tube which are in piston fit in the linear direction, wherein a semen storage space and an emitting hole of the semen storage space are formed in the front end of the piston tube; the propelling module comprises a propelling component capable of moving in the linear direction; the propelling component is provided with a first cavity, and the vibration module is arranged in the first cavity. And the piston is sleeved outside the propelling component. Due to the fact that the vibration module is close to the head of the pregnancy assisting device, vibration can be better transmitted to the head of the pregnancy assisting device, a user can be stimulated through the vibration of the head of the pregnancy assisting device before and in the placement process to relieve the resistance psychology, relax the body and the mind and make the vagina environment moist, and the pregnancy assisting device can enter more comfortably and smoothly. The pregnancy assisting device can improve pregnancy assisting physiological and psychological states before and in the process of implantation, and the pregnancy assisting process can be carried out more smoothly and easily.

An intravaginal drug delivery device based on a one-way liquid guide film comprises a drug storage chamber, a drug storage capsule is arranged in the drug storage chamber, the intravaginal drug delivery device further comprises a supporting framework and a multi-layer film structure arranged on the outer surface of the supporting framework, and the supporting framework is of an elastic framework structure designed according to the inner contour structure of the female vagina through human engineering. The multi-layer film structure comprises a bottom film fixedly arranged on the outer surface of the supporting framework, a one-way liquid guide film arranged on the bottom film and a surface film arranged on the outer side of the one-way liquid guide film. The in-vivo unit is used for being placed in the vagina, liquid medicine in the medicine storage capsule is conveyed to the affected part in a one-way mode through the one-way liquid guide film in the multi-layer film structure, and smooth flowing of the liquid medicine is guaranteed by squeezing the medicine storage capsule through pressure. The device is reasonable in structural design, simple and convenient to use, capable of directly and continuously feeding medicine to an affected part, and capable of reducing the dosage of the medicine and the influence on the vagina environment to the maximum extent.

Method for measuring the presence of a compound or a physiological parameter in the human or animal body, comprising positioning an intravaginal ring that comprises a sensor for the compound or parameter to be measured in contact with the vaginal mucosa and recording a signal produced by the sensor. It is further disclosed a method for the combined administration and measurement of compounds in the human or animal body, comprising the administration of one or more biologically active compounds and the simultaneous and / or subsequent measurement of the presence and / or concentration of the same and / or another compound and / or physiological parameter that is the result of the administration of the one or more biologically active compounds, wherein the measurement is performed with a sensor that is in contact with the vaginal mucosa.

This invention discloses an improved reservoir-type vaginal ring. The drug is loaded as a drug-carrying core by mixing it with silicone rubber, and the core is coated with a controlled-release layer made of pure silicone rubber. The drug-carrying core contains a developing agent and a dispersant. The developing agent includes barium sulfate, titanium dioxide, iodotram, iodofol, iopromide, iodophenylhexamol, and iodophenyl ester. The dispersant includes methyl silicone oil, phenyl silicone oil, vinyl silicone oil, hydrogen-containing silicone oil, and glycerin. This invention combines the advantages of existing extrusion and molding methods, effectively controlling the size and regularity of the drug-carrying core of the reservoir-type vaginal ring, ensuring stable and controllable drug content. It can effectively improve the product deformation problems caused by cutting, external force, and hot-pressing vulcanization processes in existing co-extrusion processes.

The present invention relates to levonorgestrel used in a method of providing contraception in a female subject, comprising continuous intravaginal administration of approximately 60 μg / day to approximately 100 μg / day of levonorgestrel. Furthermore, the present invention relates to levonorgestrel used in a method of treating endometriosis, endometriosis-associated pelvic pain (EAPP), and / or dysmenorrhea, comprising continuous administration of approximately 60 μg / day to approximately 160 μg / day of levonorgestrel. A delivery device, preferably an intravaginal ring, for carrying out these methods is also envisioned.

The utility model discloses a feeding type medicine applying device which comprises a medicine feeding pipe and a push-in mechanism, the medicine feeding pipe is of a cylindrical structure and is provided with a hollow medicine feeding channel, a breakable sealing film is arranged at the medicine outlet end of the medicine feeding channel, and the push-in mechanism is installed in the medicine feeding pipe in a sliding mode. The breakable sealing film is used for pushing out the medicine from the medicine outlet end of the medicine feeding channel, the breakable sealing film is made of a pH sensitive material, and the breakable threshold value of the breakable sealing film is the same as the pH value of the vagina environment. According to the technical scheme provided by the utility model, the breakable sealing film which can be broken after being put into the vagina is designed at the medicine outlet end of the medicine feeding tube, so that the problems of medicine scattering and overflowing cannot occur in the process of feeding the medicine feeding tube, and the medicine applying quality can be ensured.