31 results about "Vaginal ring" patented technology

An oval body adjustable gynecological close-range after-loading source applicator solves the problem that cervical cancer patients who cannot adapt to various vaginal environments in the prior art are prone to errors in radiotherapy doses, leading to tumor control failure and aggravated side effects. It includes an intermediate connecting frame composed of a connecting frame body, characterized in that: the source applicator bend is inserted into the bend installation hole at the upper end of the intermediate connecting frame; the oval body left hemisphere and the oval body right hemisphere symmetrically arranged on both sides of the intermediate connecting frame are both composed of hemispherical shells, and the opposite sides of the two hemispherical shells are respectively provided with concave cavities; the oval body left hemisphere and the oval body right hemisphere are connected to the intermediate connecting frame through an oval body adjustment mechanism. It has a reasonable design and a compact structure, can meet the treatment needs of different types of patients with mid- and late-stage cervical cancer radiotherapy, is easy to operate, can effectively improve the quality of radiotherapy, is non-invasive, has small side effects after treatment, is economical and practical, and has good patient compliance.

A vaginal drug delivery and / or sensor device is provided comprising a drug delivery unit and / or sensing unit and a flexible circuit board comprising a first and second area preferably connected via one bent area. Control circuitry is arranged on the first area of the FPCB. A wireless communication module is arranged on the FPCB, and a slot antenna is formed on the second area of the FPCB by providing a slot in a metal layer arranged on the second area. A microstrip line connects the wireless communication module to a connection point at or adjacent to a first end of the slot. A ceramic buffer is arranged over the slot antenna on the second area. At least one adhesive layer is arranged between the ceramic buffer and the slot antenna on the second area.

The invention relates to the technical field of biology, in particular to leukocyte esterase detection test paper and a preparation method thereof. Based on the principle of a substrate and a color developing agent, the color developing depth is in direct proportion to the concentration of the esterase, so that the concentration of the leukocyte esterase in a detection sample can be judged according to the color developing depth; meanwhile, under the auxiliary action of calcium chloride and other materials, the detection distinction degree, the detection accuracy and the detection result stability are further improved. The leukocyte esterase test paper provided by the invention is simple in sample detection method, more stable in product performance, longer in validity period and wide in application range, can be used as an auxiliary evaluation index for vagina inflammation, and is combined with a cleanliness index and the like to jointly evaluate the vagina environment.

The present invention relates to an intravaginal ring (1) comprising a core (2) and a sheath (5), the core (2) containing a first ethylene-vinyl acetate copolymer (3) with a vinyl acetate content of 28-40% by weight and at least 10% by weight of an estrogen steroid (4) based on the weight of the core, and the sheath (5) containing a second ethylene-vinyl acetate copolymer (6) with a vinyl acetate content of 18-28% by weight and at least 10% by weight of a progesterone steroid (7) based on the weight of the sheath. The inventors have found that by using the intravaginal ring according to the invention it is possible to achieve an optimal independent release of the two active ingredients, i.e. estrogen steroid and progesterone steroid, without a complex assembly of components and without the use of sophisticated multi-layer extrusion techniques.

The present invention relates to an intravaginal ring (1) a core (2) comprising a first ethylene-vinyl acetate copolymer (3) having a vinyl acetate content from 28 to 40 wt %, and at least 10 wt % of an estrogenic steroid (4) based on the weight of the core, and a sheath (5) comprising a second ethylenevinyl acetate copolymer (6) having a vinyl acetate content from 18 to 28 wt %, and at least 10 wt % of a progestational steroid (7) based on the weight of the sheath. Using the intravaginal ring according to the present the inventors have found that it is possible to attain independent and optimal release of the two active ingredients: an estrogenic steroid and a progestational steroid, without the need for complex assembly of parts and without the need to use sophisticated multi-layer extrusion technology.

The present invention relates to levonorgestrel for use in a method for providing contraception in a female subject, comprising continuous intravaginal administration of levonorgestrel of from about 60 µg / day to about 100 µg / day. The invention further relates to levonorgestrel for use in a method for treating endometriosis, endometriosis associated pelvic pain (EAPP) and / or dysmenorrhea comprising continuously administering about 60 µg / day to about 160 µg / day of levonorgestrel. Delivery devices, preferably, intravaginal rings for putting the methods in practice are also envisaged.

The invention discloses a combined medicine for preventing and treating chronic cervicitis and a preparation method thereof. The combined medicine comprises a scavenger I and a scavenger II, according to the combined medicine and the preparation method provided by the invention, comprehensive treatment is carried out by combining a mature therapy and an elimination therapy which are special for Uighur medicine, the vagina environment is changed, the local immune function is improved, and a treatment mode which is definite in curative effect, safe and low in price is provided for chronic cervicitis.

A method of producing a structure, as well as the structure produced according to the method. The method includes steps of defining an outer surface of the structure, an internal volume of the structure being defined within the outer surface; defining, within the internal volume of the structure, one or more cores; selecting a unit cell geometry; and radially arraying unit cells around a perimeter of and / or within the internal volume of the structure to form a plurality of such unit cells that extend between the one or more cores and the perimeter, within the internal volume of the structure. The structures can be produced via additive manufacturing and loaded with one or more therapeutic compounds for use as medical devices. An example of such a medical device is an intravaginal ring (IVR) or a subcutaneous rod-shaped implant device.

The invention discloses a drug sustained-release control system for intelligently monitoring a vagina environment, and the system comprises a data monitoring device which is disposed in a vagina region of a target user and is used for obtaining the sensing data of the vagina region; the data processing device is connected to the data monitoring device and used for determining a drug release instruction corresponding to the target user according to the sensing data; and the drug sustained release device stores treatment drugs, is arranged in the vagina area, is connected to the data processing device, and is used for releasing the treatment drugs to the vagina area according to the drug release instruction so as to treat the target user. Therefore, the vaginal environment of the user can be monitored accurately in real time based on the data monitoring device, accurate release of the medicine is controlled based on the monitoring result, vaginal bacteria of the user can be killed more timely and accurately, and more intelligent auxiliary service is provided for treatment of the user.

The present application belongs to the technical field of artificial semen collection devices for sheep, and particularly relates to a sheep bionic semen collection device; the device comprises a silica gel heat storage liquid bag false vagina, a disposable semen collection inner membrane bag, a heat preservation roll and a columnar stimulation convex, the silica gel heat storage liquid bag false vagina comprises a silica gel column, a non-linear pipeline and a heat storage liquid bag, the heat storage liquid bag is filled with phase change heat storage liquid, and the non-linear pipeline penetrates the central axis of the silica gel column; the present application simulates the vaginal environment through folds, improves the simulation effect of the vagina, stores and releases heat by using the phase change heat storage liquid, is conducive to keeping the temperature of the sheep bionic semen collection device constant, according to the thermal expansion and cold contraction characteristics of the phase change heat storage liquid, squeezes the non-linear pipeline, realizes moderate tension of the false vagina, does not need to add water and pressure, is conducive to improving the success rate of semen collection, through the disposable semen collection inner membrane bag, the silica gel bionic vagina is exempted from decontamination, through the columnar stimulation convex, it is helpful for the ram to release semen, and the semen collection effect is improved.

In some example embodiments, there is provided a pessary apparatus configured to alleviate pelvic organ prolapse and urinary incontinence. This pessary may a urethral support knob having a first opening and a second opening; a cylindrical stem having a proximate end, a distal end, an exterior surface, and an interior surface that forms a hollow interior of the cylindrical stem, wherein the proximate end is coupled to the second opening of the urethral support knob; and a pessary. Related apparatus, systems, methods, and / or articles of manufacture are also disclosed.

To reduce or eliminate temporal ring distortion occurring in an intravaginal ring device made of a copolymeric silicone matrix.SOLUTION: Provided is an intravaginal ring device including a flat and circular or elliptical ring made of a non-segmented, non-coated thermoplastic elastomer excluding copolymeric silicone, the ring containing one or more non-hormonal sperm-immobilizing agents. The ring surrounds a curved, non-absorbable polymer barrier attached to the ring, and the ring covers a uterine cervix when inserted into a subject.SELECTED DRAWING: Figure 1

The present invention relates to levonorgestrel for use in a method of providing contraception to a female subject comprising a sustained intravaginal administration of levonorgestrel of about 60-100 [mu] g / day. The invention further relates to levonorgestrel for use in a method of treating endometriosis, endometriosis-associated pelvic pain (EAPP) and / or dysmenorrhea, comprising a sustained administration of levonorgestrel of about 60-160 [mu] g / day. Dosing devices, preferably vaginal rings, for carrying out these methods are also contemplated.

The present disclosure relates to a multi-component intravaginal ring (IVR) for improved release of non-hormonal agents that can be used in a multi-purpose prophylactic technology (MPT) that simultaneously prevents accidental pregnancy and prevents or treats sexually transmitted infections (STIs) while optimizing vaginal health.

Intravaginal drug delivery devices, including intravaginal rings, are provided herein. The devices include a reservoir of at least one vaginally administrable drug wherein the reservoir is surrounded at least in part by a hydrophilic elastomer. The devices are capable of exhibiting a substantially zero order release profile of drug over extended periods of time. Also disclosed are methods for making the devices and methods of using the devices to prevent or treat a biological condition.

Nanoparticles and nanoparticle-releasing vaginal rings for intermediate- to long-term delivery of drugs to the female genital and reproductive tract have been developed. The nanoparticles are loaded with drugs and coated with a sheddable poly(ethylene glycol) (PEG) layer that promotes mucus penetration and then converts to an adhesive form after penetration. This platform technology readily distributes drug through the mucosa and throughout the vaginal tissue, enhances local retention of drugs within the vaginal tissue, thereby providing a sustained delivery of drugs beyond the natural shedding and turnover of vaginal mucous and epithelial cells.

The invention discloses a female bacteriostatic device, and relates to the technical field of bacteriostatic compositions and bacteriostasis. The device comprises an LED light source, a micro liquid pump and a liquid storage bin, wherein a bacteriostatic composition contained in the liquid storage bin comprises epsilon-polylysine, vitamin B, sodium lignin sulfonate, a zein and hydroxypropyl trimethyl ammonium chloride chitosan compound, calcium peroxide and the like. The composition is prepared into freeze-dried gel through a freeze-drying process, when in use, the freeze-dried gel is redissolved to form a gel state, and the antibacterial effect is enhanced through irradiation of an LED light source. The problem that vitamin B is easy to decompose in the vagina environment is effectively solved, the stability and sterilization efficiency of antibacterial components are improved, and the composition is suitable for prevention and treatment of vulvovaginal candiditis and multi-bacterial mixed vaginitis.

Provided is an agent for improving the balance of normal vaginal microbiota that is effective in keeping a favorable vaginal state. The present invention provides an agent for improving the balance of normal vaginal microbiota using sophorose and / or laminaribiose. Sophorose and / or laminaribiose have functionality for promoting the growth of beneficial bacteria that have a beneficial vaginal effect while suppressing the growth of bacteria that have the possibility of causing an adverse vaginal effect among normal vaginal microbiota. This agent for improving the balance of normal vaginal microbiota can be suitably used for the purpose of keeping a favorable vaginal state while maintaining the balance of normal vaginal microbiota.

Disclosed is a vaginal ring delivering estriol. The ring is suitable for use in the treatment of vaginal and vulva atrophy. It has a core-shell structure of ethylene vinyl acetate copolymers. Both the core and the shell are loaded with estriol, with the concentration of estriol in the core exceeding that in the shell. The core and shell have a different copolymer composition, with the vinyl acetate in the core being higher than that in the shell.

The invention relates to the technical field of antibacterial gels, and discloses a vagina internal environment-imitating antibacterial gel, which is prepared by the following steps: S1, sufficiently swelling a phase A for later use at normal temperature; s2, fully dissolving the phase B, adding the phase A, and uniformly stirring; and S3, fully stirring and dissolving the phase C, the phase D and the phase E, adding the mixed phase in the S2, stirring, uniformly stirring, standing or defoaming under negative pressure, and filling. The radix sophorae flavescentis extract has the effects of resisting bacteria, diminishing inflammation, relieving itching, easing pain and improving the vaginal environment on the vagina, the peony root bark extract has the effects of resisting inflammation, resisting oxidation and improving skin health on the vagina, and the fructus cnidii extract can relieve pudendum wet itching and the like on the vagina; chitosan contained in the quaternized amino acid has the effects of promoting healing of the vagina and improving the vagina environment, meanwhile, the chitosan and quaternary ammonium salt in the quaternized amino acid jointly have the sterilization effect, and an amino acid group in the quaternized amino acid has the moisturizing effect.

The pregnancy assisting device comprises a piston and a piston tube which are in piston fit in the linear direction, wherein a semen storage space and an emitting hole of the semen storage space are formed in the front end of the piston tube; the propelling module comprises a propelling component capable of moving in the linear direction; the propelling component is provided with a first cavity, and the vibration module is arranged in the first cavity. And the piston is sleeved outside the propelling component. Due to the fact that the vibration module is close to the head of the pregnancy assisting device, vibration can be better transmitted to the head of the pregnancy assisting device, a user can be stimulated through the vibration of the head of the pregnancy assisting device before and in the placement process to relieve the resistance psychology, relax the body and the mind and make the vagina environment moist, and the pregnancy assisting device can enter more comfortably and smoothly. The pregnancy assisting device can improve pregnancy assisting physiological and psychological states before and in the process of implantation, and the pregnancy assisting process can be carried out more smoothly and easily.

The present disclosure provides a vaginal drug delivery and / or sensor device comprising a drug delivery unit and / or a sensing unit and a flexible circuit board comprising a first region and a second region, preferably connected via a curved region. The control circuitry is disposed on the first region of the FPCB. The wireless communication module is disposed on the FPCB, and a slot antenna is formed on the second region of the FPCB by providing a slot in a metal layer disposed on the second region. The microstrip line connects the wireless communication module to a connection point at or adjacent to the first end of the slot. A ceramic buffer is disposed over the slot antenna on the second region. At least one adhesive layer is disposed between the ceramic buffer and the slot antenna on the second region.

The present invention relates to a method for determining the presence of a circulating tumor marker in the human body, comprising detecting the tumor marker in the vagina, wherein the tumor marker originates from a part of the body that is not the vagina. In a preferred embodiment, the tumor marker is detected by means of an aptamer. Even more preferably, the aptamer is present in a vaginal ring device. The vaginal ring device suitably comprises a diagnostic device for performing an intravaginal diagnosis or measurement therefor. The method can for example be used in the continuous monitoring of circulating tumor markers in oncologic patients or in the pretreatment and posttreatment follow-up of oncologic patients. The invention further relates to a vaginal diagnostic ring device for performing the method.

An intravaginal drug delivery device based on a one-way liquid guide film comprises a drug storage chamber, a drug storage capsule is arranged in the drug storage chamber, the intravaginal drug delivery device further comprises a supporting framework and a multi-layer film structure arranged on the outer surface of the supporting framework, and the supporting framework is of an elastic framework structure designed according to the inner contour structure of the female vagina through human engineering. The multi-layer film structure comprises a bottom film fixedly arranged on the outer surface of the supporting framework, a one-way liquid guide film arranged on the bottom film and a surface film arranged on the outer side of the one-way liquid guide film. The in-vivo unit is used for being placed in the vagina, liquid medicine in the medicine storage capsule is conveyed to the affected part in a one-way mode through the one-way liquid guide film in the multi-layer film structure, and smooth flowing of the liquid medicine is guaranteed by squeezing the medicine storage capsule through pressure. The device is reasonable in structural design, simple and convenient to use, capable of directly and continuously feeding medicine to an affected part, and capable of reducing the dosage of the medicine and the influence on the vagina environment to the maximum extent.

Method for measuring the presence of a compound or a physiological parameter in the human or animal body, comprising positioning an intravaginal ring that comprises a sensor for the compound or parameter to be measured in contact with the vaginal mucosa and recording a signal produced by the sensor. It is further disclosed a method for the combined administration and measurement of compounds in the human or animal body, comprising the administration of one or more biologically active compounds and the simultaneous and / or subsequent measurement of the presence and / or concentration of the same and / or another compound and / or physiological parameter that is the result of the administration of the one or more biologically active compounds, wherein the measurement is performed with a sensor that is in contact with the vaginal mucosa.

This invention discloses an improved reservoir-type vaginal ring. The drug is loaded as a drug-carrying core by mixing it with silicone rubber, and the core is coated with a controlled-release layer made of pure silicone rubber. The drug-carrying core contains a developing agent and a dispersant. The developing agent includes barium sulfate, titanium dioxide, iodotram, iodofol, iopromide, iodophenylhexamol, and iodophenyl ester. The dispersant includes methyl silicone oil, phenyl silicone oil, vinyl silicone oil, hydrogen-containing silicone oil, and glycerin. This invention combines the advantages of existing extrusion and molding methods, effectively controlling the size and regularity of the drug-carrying core of the reservoir-type vaginal ring, ensuring stable and controllable drug content. It can effectively improve the product deformation problems caused by cutting, external force, and hot-pressing vulcanization processes in existing co-extrusion processes.

The pregnancy assisting device comprises a piston and a piston tube which are in piston fit in the linear direction. A semen storage space and an emitting hole of the semen storage space are formed in the front end of the piston tube. The propelling module comprises a propelling component capable of moving in the linear direction; the propelling component is provided with a first cavity, and the vibration module is arranged in the first cavity. And the piston is sleeved outside the propelling component. Due to the fact that the vibration module is close to the head of the pregnancy assisting device, vibration can be better transmitted to the head of the pregnancy assisting device, a user can be stimulated through the vibration of the head of the pregnancy assisting device before and in the placement process to relieve the resistance psychology, relax the body and the mind and make the vagina environment moist, and the pregnancy assisting device can enter more comfortably and smoothly. According to the pregnancy assisting device, the pregnancy assisting physiological and psychological states can be improved before and in the pregnancy assisting process, and the pregnancy assisting process can be carried out more smoothly and easily.

The invention provides a vagina cerclage and take-out device for laparoscopic cervical cancer surgery, which comprises a loop ligature ring and a cerclage vagina auxiliary rod, the loop ligature ring comprises a clamping head, a moldable section and a clamping belt, and the cerclage vagina auxiliary rod comprises a functional end and an operating rod. According to the vagina cerclage and take-out device for the laparoscopic cervical cancer surgery, by arranging the specially designed loop ligature ring, the process of vagina cerclage under a laparoscope can be facilitated, the surgery time is effectively shortened, the surgery risk caused by inconvenient operation is effectively reduced, the accuracy and stability of the vagina cerclage step are greatly improved, and the operation efficiency is improved. The auxiliary rod for cerclage of the vagina accurately indicates the resection length of the vagina, reduces falling of a loop ligature ring after the vagina is cut off, can more conveniently loop ligature the vagina, indicates the resection length of the vagina, reduces tumor tissue exposure caused by falling of the loop ligature ring, and provides more reliable guarantee for operation prognosis of a patient. And the quality and the effect of the laparoscopic cervical cancer operation are optimized on the whole.

Geometrically complex intravaginal rings, systems and methods of making the same are provided herein. Disclosed herein are geometrically complex intravaginal rings with tunable and enhanced drug release, which in some embodiments can be fabricated by 3D printing technologies. The disclosed IVRs include a ring structure comprising a plurality of unit cells or macroscopic and / or microscopic architecture, which can be tuned to control the loading capacity of an active compound within the IVR, the diffusion of an active compound from the IVR, the surface area of the IVR, and / or the mechanical properties of the IVR. The disclosed geometrically complex IVRs can provide superior control over drug loading and drug release compared to conventional IVRs fabricated by injection molding or hot-melt extrusion.

The present invention relates to levonorgestrel used in a method of providing contraception in a female subject, comprising continuous intravaginal administration of approximately 60 μg / day to approximately 100 μg / day of levonorgestrel. Furthermore, the present invention relates to levonorgestrel used in a method of treating endometriosis, endometriosis-associated pelvic pain (EAPP), and / or dysmenorrhea, comprising continuous administration of approximately 60 μg / day to approximately 160 μg / day of levonorgestrel. A delivery device, preferably an intravaginal ring, for carrying out these methods is also envisioned.