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Liquid dressing and preparation method thereof

A technology of liquid dressing and acetate buffer solution, which is applied in the field of medicine, can solve the problems of non-selectivity of harmful microorganisms, poor air permeability, unfavorable wound healing, vaginal environment imbalance, etc., achieve good moisturizing and adhesion, and short time to overcome the effect , speed up the healing effect

Active Publication Date: 2021-01-29
SHENZHEN HUAZHONG BIOLOGICAL PHARMA MACHINERY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In view of the shortcomings of the existing liquid dressings such as short drug effect time, poor air permeability after film formation, which is not conducive to wound healing, and slow film formation speed, it is easy to cause pH imbalance in the vaginal environment when used in gynecological episiotomy wounds or gynecological examination wounds and for vaginal flora. The problem that harmful microorganisms are not selective, the invention provides a liquid dressing and a preparation method thereof

Method used

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  • Liquid dressing and preparation method thereof
  • Liquid dressing and preparation method thereof
  • Liquid dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] A liquid dressing, comprising the following components by mass percentage:

[0039] 0.5% polyvinylpyrrolidone, 0.5% sodium alginate, 1.0% glycerin, 3.0% vitamin C, 0.5% propylene glycol, 5.0% polyethylene glycol, 15.6% acetate buffer and the balance of purified water.

[0040] Acetate buffer Acetate buffer is obtained by adding 5.1g of sodium acetate and 20mL of glacial acetic acid into water and distilling the volume to 250mm with water.

[0041] The preparation method of above-mentioned liquid dressing comprises the following steps:

[0042] a. Mix the above-mentioned polyvinylpyrrolidone, sodium alginate, glycerin, plasticizer, humectant and purified water and stir at a stirring speed of 200r / min for 1h, then let stand for 6h to obtain solution 1;

[0043] b. Add the above-mentioned vitamin C into a small amount of acetate buffer solution, stir and dissolve to obtain solution 2;

[0044] c. Add solution 2 to acetate buffer in solution 1 and mix evenly to obtain a l...

Embodiment 2

[0046] A liquid dressing, comprising the following components by mass percentage:

[0047] Polyvinylpyrrolidone 2.0%, sodium alginate 1.0%, glycerin 2.0%, vitamin E 4.0%, propylene glycol 1.0%, polyethylene glycol 6.0%, acetate buffer 9.3% and the balance of purified water.

[0048] Acetate buffer Acetate buffer is the same as in Example 1.

[0049] The preparation method of above-mentioned liquid dressing comprises the following steps:

[0050] a. Mix the above-mentioned polyvinylpyrrolidone, sodium alginate, glycerin, plasticizer, humectant and purified water and stir at a stirring speed of 250r / min for 1h, then let stand for 7h to obtain solution 1;

[0051] b. Add the above-mentioned vitamin C into a small amount of acetate buffer solution, stir and dissolve to obtain solution 2;

[0052] c. Add solution 2 to acetate buffer in solution 1 and mix evenly to obtain a liquid dressing with a pH of 3.5.

Embodiment 3

[0054] A liquid dressing, comprising the following components by mass percentage:

[0055] Polyvinylpyrrolidone 3.0%, sodium alginate 1.2%, glycerin 3.0%, vitamin C 5.0%, propylene glycol 1.2%, polyethylene glycol 7.0%, acetate buffer 6.2% and the balance of purified water.

[0056] Acetate buffer Acetate buffer is the same as in Example 1.

[0057] The preparation method of above-mentioned liquid dressing comprises the following steps:

[0058] a. Mix the above-mentioned polyvinylpyrrolidone, sodium alginate, glycerin, plasticizer, humectant and purified water and stir for 1.5h at a stirring speed of 300r / min, then let it stand for 8h to obtain solution 1;

[0059] b. Add the above-mentioned vitamin C into a small amount of acetate buffer solution, stir and dissolve to obtain solution 2;

[0060] c. Add solution 2 to acetate buffer in solution 1 and mix evenly to obtain a liquid dressing with a pH of 4.1.

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Abstract

The invention relates to the technical field of medicines, and particularly discloses a liquid dressing and a preparation method thereof. The liquid dressing is prepared from the following componentsin percentage by mass: 0.5-5.0 percent of polyvinylpyrrolidone, 0.5-2.0 percent of sodium alginate, 1.0-5.0 percent of glycerol, 3.0-8.0 percent of vitamin C, 0.5-2.0 percent of a plasticizer, 5.0-10.0 percent of a humectant, 2.0-15.6 percent of an acetate buffer solution and the balance of purified water. The liquid dressing has the advantages of being long in acting time, good in air permeability after film forming, capable of helping wound healing and high in film forming speed, does not cause vaginal environment pH imbalance when being used for gynecological perineum lateral incision wounds or gynecological examination wounds, and has the characteristic of selectively inhibiting harmful microorganisms in vaginal flora.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a liquid dressing and a preparation method thereof. Background technique [0002] Skin injuries are very common in people's daily life, including abrasions, scratches, cuts, scalds and burns. Traditional wound care products such as band-aids / gauze have disadvantages such as strong foreign body sensation, easy adhesion to the wound, and easy to fall off after being wet. Moreover, some wounds cannot use traditional wound care products such as band-aids / gauze. For example, wounds produced by episiotomy during childbirth and gynecological examination wounds. Therefore, non-chronic wounds such as small wounds, abrasions, cuts, burns, episiotomy wounds, sutured wounds after outpatient operations, and gynecological examination wounds urgently need to find a safe and effective nursing product. [0003] Based on the theory of moist healing, liquid dressings for skin injuries have beco...

Claims

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Application Information

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IPC IPC(8): A61L26/00
CPCA61L26/0023A61L26/0014A61L26/0066A61L26/0061A61L2300/21A61L2300/404C08L5/04C08L39/06
Inventor 肖承荣李立家胡焰杨梅易经达
Owner SHENZHEN HUAZHONG BIOLOGICAL PHARMA MACHINERY
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