85 results about "Vaginal flora" patented technology

Disclosed are methods of quantifying microflora in vaginal samples. Quantitative assessment of vaginal microflora by real-time PCR to create a profiling of Lactobacillus species, Gardnerella vaginalis, Atopobium vaginae, Megasphaera Type 1 and Type 2 and BVAB2 permits evaluation of bacterial vaginosis. Kits containing reagents for quantitative assessment of microflora are also disclosed.

The invention relates to a water soluble body lubricant with natural antibacterial components and with pH value consistence with pH value of vagina, which is characterized by comprising the following components in parts by weight: 10-30 parts of glycerol, 1-5 parts of 1,2-propylene glycol, 0.1-3 parts of natural antibacterial components, 1-10 parts of pH regulators, 0.1-2 parts of tackifiers, 0.1-2 parts of hyaluronic acid and 48-88 parts of deionized water. The water soluble body lubricant can be used as the lubricant for sexual life, the lubricant on condoms or the external bactericide for the female to prevent and treat bacterial infection in the vagina every day, is temperate in property, has pH value consistent with the vaginal environment, has broad spectrum antibacterial effect, does not change the vaginal flora structure or result in drug resistance of bacteria, does not contain chemical preservatives, is safer to use and has certain effects on moisturizing, protecting and repairing the private parts.

The present invention relates to a pharmaceutical formulation for stimulating the growth of gram-positive bacilli and increasing the acidity in the vagina which comprises sucrose and / or maltose, to the use of certain sucrose and / or maltose, in preparing the pharmaceutical formulation for stimulating the growth of gram-positive bacilli and increasing the acidity in the vagina, in particular to a method for stimulating the growth of gram-positive bacilli and increasing the acidity in the vagina, treating the reduction of gram-positive bacilli and the lowness of acidity in vagina as well as the vaginitis and the disturbance of vaginal bacterioflora accompanying the reduction of gram-positive bacilli, especially bacterial vaginal disease.< / PTEXT>

The present invention relates to the use of benzoic acid and / or its sodium salt in combination with saccharide(s) as active components in the manufacture of a vaginal composition for modulating vaginal flora and vaginal acidity, thereby maintaining the pH value of vaginal secretion within a range from 3.5 to 4.5; and the present invention further relates to a vaginal composition and a method for modulating and maintaining normal vaginal flora and vaginal acidity.

The invention discloses a Lactobacillus crispatus and an application. The Lactobacillus crispatusis is preserved in the China General Microbiological Culture Collection Center (CGMCC) with accession number of CGMCC NO.6406. The Lactobacillus crispatus has high acid resistance, high-yield hydrogen peroxide characteristic and vagina pathogenic bacteria growth inhibition effect, and the invention also relates to an application of the Lactobacillus crispatus LCR15 for adjusting vaginal flora, preventing and treating colpitis.

The invention relates to the medicines for gynecopathy, in particular to gel for adjusting microecology in vaginas of women, solving the problem that the traditional gynecological lotion kills probiotics while killing pathogens, thus causing vaginal flora imbalance and low immunity and further causing repeated vaginitis. The gel comprises the following components according to mass concentration: 0.5-2% of Carbomer, 0.1-1% of soy peptide, 0.001-0.01% of isoflavone, 0.5-3.5% of carotene and 0.3-3% of tea tree oil. The gel achieves the aim of suppressing pathogens by promoting lactobacillus proliferation. At present, the products in the market aim to kill the bacteria but finally disturb normal flora balance. The gel increases the absolute number of the lactobacillus, a predominant bacterium, simultaneously reduces the pathogens, maintains the balance of microecology in vaginas and improves vaginal cleanliness and the immunity of the vagina mucosa, thus achieving the aims of preventing gynecological vagina inflammation and reducing the reoccurrence rate of gynecological vaginitis. Besides, the formula of the gel is pure vegetable protein, thus being safer than other bacteriostats and bactericides.

A method and system for testing fluids from a patient is provided. In one embodiment, a portable device is configured with one or more testing modules adapted perform one or more tests on a fluid sample in order to determine if a patient has bacterial vaginosis. A timer module coupled to a sample transport is configured to move a vaginal fluid sample between one or more testing modules at various stages along a predetermined testing path. In an embodiment, the timer module is configured to move the vaginal fluid sample between the testing modules along a circular testing path. The vaginal fluid sample may be processed in sequential order over predetermined time periods with respect to the processing performed by the testing module in order to detect the presence of, or lack of, Lactobacilli in the patient's vaginal flora to determine whether or not the patient has bacterial vaginosis.

The invention relates to active lactic acid bacteria capsules with a treatment and prevention effect on vaginitis. The lactic acid bacteria capsules capable of simultaneously adjusting dysbacteriosis of intestinal tracts and vagina and emphasizing treatment and prevention of the vaginitis are developed for achieving comprehensive effects. According to the technical scheme, excipient and lactic acid bacteria mixed bacteria powder are wrapped in the active lactic acid bacteria capsules with the treatment and prevention effect on vaginitis, and the lactic acid bacteria mixed bacteria powder comprises lactobacillus crispatus powder and other lactic acid bacteria subspecies powder with an effect of adjusting the intestinal flora. The active lactic acid bacteria capsules can be used for treating the vaginitis by adopting oral administration and intra-vaginal use; the oral lactobacillus can effectively improve the immunity of mucosa by stimulating the immune response of the intestinal mucosa, adjust the overall function state of a human body and well treat the vaginitis; and a large quantity of lactobacillus proliferated in the intestinal tract can inhibit growth of intestinal bacteria and reduce the risk of intestinal bacteria infection in vagina.

An herbal vaginal composition for treating vaginal infections while maintaining the natural vaginal flora, herbal ingredients comprising: coconut oil as the base ingredient, shea butter, neem oil, lavender oil, vitamin E, lactobacillus, green tea, tea tree, ylang ylang, sweet orange, myrrh, frankincense, nirvanas base, and clove oil.

A method utilizing a dissolvable device for the internal delivery of medication and more particularly to the use of fibers or non-woven fabrics made of a safe polymer material incorporating a medication that is released by dissolution of the fibers or non-woven fabrics over time, and more particularly a treatment method for controlling or regulating the pH in the vagina by stabilizing and adjusting the pH in the vagina by minimizing the impact of the vaginal flora.

The invention relates to the medicines for gynecopathy, in particular to physiological balance liquid for adjusting microecology in vaginas of women, solving the problem that the traditional gynecological lotion kills probiotics while killing pathogens, thus causing vaginal flora imbalance and low immunity and further causing repeated vaginitis. The physiological balance liquid is formed by major materials, auxiliary materials and water, wherein the major materials include the following components according to mass concentration: 0.7-1% of sodium chloride, 0.01-0.04% of potassium chloride, 0.01-0.04% of calcium chloride, 0.01-0.04% of magnesium sulfate, 0.001-0.01% of manganese sulfate and 0.01-0.05% of glucose; and the auxiliary materials include the following components according to mass concentration: 0.1-1% of soy peptide, 0.001-0.01% of isoflavone, 0.05-0.6% of tea tree oil and 0.002-0.04% of carotene. The physiological balance liquid conforms to physiological conditions of the vagina mucosa, increases the absolute number of the lactobacillus, a predominant bacterium, reduces the pathogens, maintains the balance of microecology in vaginas and improves vaginal cleanliness and the immunity of the vagina mucosa, thus achieving the aims of preventing gynecological vagina inflammation and reducing the reoccurrence rate of gynecological vaginitis. The physiological balance liquid has good biocompatibility and no irritation or side effects and is safe.

The invention relates to a traditional Chinese medicine composition, and in particular relates to a bacteria-resisting, inflammation-diminishing and itching-relieving traditional Chinese medicine composition and a preparation method and application thereof. The traditional Chinese medicine composition avoids having toxic and side effects on human bodies and has the functions of resisting bacteria, diminishing inflammation, relieving itching, regulating vaginal flora disturbance, increasing the quantity of vaginal lactobacillus and improving the immune functions of the bodies. The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 20-30 parts of fructus cnidii, 20-30 parts of giant knotweed rhizome, 20-30 parts of radix sophorae flavescentis, 10-20 parts of dandelions, 10-15 parts of densefruit pittany root-bark, 10-20 parts of radix stemonae, 5-10 parts of amur corktree bark, 5-10 parts of dahurian angelica root, 5-10 parts of white alum, 3-6 parts of cloves and 30-50 parts of golden larch bark. The traditional Chinese medicine composition has the functions of clearing away heat and toxic materials, dispelling wind and eliminating dampness and killing parasites to relieve itching and can be used on health products such as sanitary towels in aid of gynecological disease treatment.

A method for application of natural vaginal flora transplantation in treating gynecological inflammation is characterized in that feminine dysbacteriosis is recovered by means of the opsonization of normal feminine vagina probiotics florae on feminine vaginal diseases, so that the feminine urogenital tract health is maintained. The method is also characterized in that bacteria are used as an antibacterial agent, and the micro-ecology treatment method free of drug resistance and side effects is realized by maintaining the stability of feminine lower genital tract florae; the adopted preparation is a vaginal embolism which is easy to make, convenient to use and quite low in cost.

A method utilizing a dissolvable device for the internal delivery of medication and more particularly to the use of films made of a safe polymer material incorporating a medication that is released by dissolution of the film over time, and more particularly a treatment method for controlling or regulating the pH in the vagina by stabilizing and adjusting the pH in the vagina by minimizing the impact of the vaginal flora.

The invention relates to the application of a probiotic factor and lactobacillus mixture in preventing and treating vaginitis. Prebiotic factors can promote the reproduction of beneficial bacteria Lactobacillus and Bifidobacteria in women's vagina, and inhibit the growth of vaginal pathogenic bacteria through space occupation competition and secretion of hydrogen peroxide. At the same time, the reproduction of Lactobacillus can maintain the weak acidic environment of the vagina and adjust the pH value of the vagina. The addition of Lactobacillus can effectively supplement vaginal probiotics, help probiotics multiply rapidly, and occupy the dominant position in the structure of vaginal flora. Through the effective combination of probiotic factors and lactobacilli, the present invention has remarkable efficacy in preventing and treating vaginitis, especially recurrent vaginitis.

The invention provides a bacteriostatic and antiviral traditional Chinese medicine gel composition, which is prepared from the following ingredients in parts by weight: 1 to 10 parts of probiotic fermentation liquid, 0.1 to 5 parts of cortex phellodendri concentration solution, 0.1 to 5 parts of radix sophorae flavescentis concentration solution, 0.01 to 5 parts of rosemary essential oil, 5 to 20parts of witch hazel extraction liquid, 5 to 20 parts of seaweed polypeptide extraction liquid, 0.1 to 1 part of menthol, 0.1 to 0.5 part of nanometer silver, 0.1 to 0.5 part of trichloro hydroxydiphenyl ether, 0.2 to 5 parts of Carbomer, 0.3 to 3 parts of triethanolamine, 2 to 20 parts of sorbitol, 0.01 to 0.1 part of EGCG palmitate, 0.01 to 1 part of tea polyphenol, 0.5 to 2 parts of solubilizers C040 and a proper amount of purified water to reach the total quantity of 100 parts. The probiotic fermentation liquid is added, so that the vaginal flora balance is realized.

The invention aims to provide a joint vaginitis detection kit which is convenient, quick and sensitive to operate, does not need any high-end instrument and equipment, and has low price. The technical scheme of the invention is to provide the joint vaginitis detection kit comprising a clamp-shaped reaction device with four dry chemical reaction blind holes, diluent and chromogenic reagent; and the four blind holes are respectively provided with a hydrogen peroxide concentration determination test reagent pad, a sialic acid glucoside enzyme activity test reagent pad, a leukocyte esterase activity determination test reagent pad and a vaginal fluid pH test reagent pad. The joint vaginitis detection kit can simultaneously test four indexes, i.e. the pH value of vaginal secretion, hydrogen peroxide, sialic acid glucoside enzyme and leukocyte esterase. Through the four indexes, the micro-ecological environment of vagina is determined, and the joint vaginitis detection kit is for identifying bacterial vaginosis of normal vaginal flora and bacteria groups.

The invention discloses a method for preparing a human vaginal microecological preparation-probiotics condom. The method is characterized in that probiotics are added to the front end of a condom or a stock solution by adopting the ecology theory of bacteria inhibition through probiotics, so that probiotics are fully and evenly distributed into female vaginas when men and women make love, thus the functions of restoring vaginal flora balance and self-cleaning are achieved; gynecological diseases such as bacterial vaginitis (BV), colpitis mycotica and trichomonas vaginitis are effectively treated and prevented. The method has the advantages that the method that the probiotics enter the vagina to adjust vaginal flora balance is simple and convenient, has both treating and protecting functions, is used for supporting the healthy energy, and is good in treatment effect, free of recurrence after curing, high in efficiency, economical, safe and wide in application range.

The present invention relates to a pharmaceutical formulation for stimulating the growth of gram-positive bacilli and increasing the acidity in the vagina which comprises sucrose and / to maltose, to the use of certain sucrose and / or maltose, in preparing the pharmaceutical formulation for stimulating the growth of gram-positive bacilli and increasing the acidity in the vagina, in particular to a method of stimulating the growth of gram-positive bacilli and increasing the acidity in the vagina, treating the reduction of gram-positive bacilli and the lowness of acidity in vagina as well as the vaginitis and the disturbance of vaginal bacterioflora accompanying the reduction of gram-positive bacilli, especially bacterial vaginal disease.

The invention relates to the application of a probiotic complex in the prevention and treatment of vaginitis. Prebiotic factors can singlely promote the reproduction of beneficial bacteria Lactobacillus and Bifidobacteria in the vagina, and inhibit the growth of vaginal pathogenic bacteria through space-occupying competition. At the same time, the reproduction of lactobacilli can secrete hydrogen peroxide to kill harmful bacteria. The reproduction of Lactobacillus can also produce a large amount of acidic components, maintain the normal pH value of the vagina, inhibit the growth of harmful bacteria, and regulate the structure of vaginal flora. The invention can effectively prevent and treat vaginitis.

A method utilizing a dissolvable device for the internal delivery of medication and more particularly to the use of films, fibers or non-woven fabrics made of a safe polymer material incorporating a medication that is released by dissolution of the films, fibers or non-woven fabrics over time, and more particularly a treatment method for controlling or regulating the pH in the vagina by stabilizing and adjusting the pH in the vagina by minimizing the impact of the vaginal flora.

The invention discloses a nifuratel-nysfungin soft capsule suppository. The nifuratel-nysfungin soft capsule suppository comprises 500mg of nifuratel, 200000IU of nysfungin, 8mg of promestriene, 25mg of carbomer, 700mg of glycerinum, 6mg of ethylparaben, 294mg of triethanolamine, 800mg of ethyl alcohol and 7.5g of water. The invention also discloses a preparation method of the nifuratel-nysfungin soft capsule suppository. The nifuratel-nysfungin soft capsule suppository can kill bacteria, mould and trichomonad, effectively protect lactobacillus and promote vaginal flora to restore balance, thus realizing the purpose of 'ecological treatment'; and the soft capsule suppository has both the dosage form characteristic of soft capsule (good stability of capsule core, capsule skin and drug) and local drug delivery characteristic of suppository.

The invention discloses female vaginal dominant bacteria lactobacillus gasseri H87 and application thereof in preparing a premature delivery preventing medicine, and belongs to the technical field ofmedical microorganisms. The L.gasseri H87 is a novel bacterial genus of a lactobacillus gasseri genus separated from a human body, a repelling effect is avoided, specifically, antibacterial peptide gassericin of the L.gasseri H87 maintains balance of a vaginal flora, and has higher capability of adhering to vaginal epithelial cells, the risk of inflammation of a urogenital region of a patient is reduced, meanwhile, the risk of pregnancy complications of a pregnant woman is reduced, and the strain can be stored for a long term, so that production is facilitated. Lactobacillus gasseri deficiencycan cause a bad pregnancy outcome, such as premature delivery, for the pregnant woman, and a female vaginal microenvironment is reshaped, and therefore the strain can well meet the actual clinical application requirements, and a novel idea is provided for reducing the premature birth rate.

The invention relates to compound lactobacillus vagina cleaning hygiene body lotion for preventing or treating vaginitis and technology thereof. Strain seed liquid of lactobacillus debrueckii is inoculated with a culture medium containing 1 to 3 weight percent of glucose, 0.5 to 1.5 weight percent of soy peptone, 0.5 to 1 weight percent of yeast extract, 0.5 to 1 weight percent of fish peptone and 0.3 to 0.5 weight percent of tribasic ammonium citrate, after the anaerobic fermentation at the temperature of 36-39 DEG C, 20 to 40 weight percent of centrifugal separating liquid is taken, 1 to 3 percent of phycite, 1 to 3 percent of lactic acid, 1 to 3 percent of peroxide, 0.2 to 0.5 percent of borneol, 1 to 3 percent of peppermint oil and the balance of water can also be taken, and the taken materials and the water are fully mixed together. The metabolites of lactobacillus, such as lactic acid, acetic acid, peroxide, bacteriocin, other volatile fatty acids, useful enzymes, polypeptides and other actives are used for regulating the vaginal dysbacteriosis, effectively inhibiting external-attacking bacteria and few excessively propagating vaginal floras, restoring the natural ability of resisting the disturbance of heterotrophic bacteria of vagina and promotes the biological self-cleaning function of the vagina to prevent and treat bacteritic vaginitis.

The present invention relates to a novel Lactobacillus sp. isolation strain having an activity to inhibit the growth of vaginitis pathogens, and a pharmaceutical composition, a health functional food, and a cleansing product, comprising the strain as an active ingredient. Therefore, the present invention exhibits an effect of inhibiting the growth of Sneathia spp. pathogens associated with the infection with human papillomavirus (HPV) and the incidence of bacterial vaginitis, Gardnerella vaginalis as a vaginitis pathogen, and Candida albicans as a causative bacteria of Candidal vaginitis, and an effect of recovering and maintaining the vaginal microflora, and thus can be used for the prevention and treatment of female vaginitis.

The invention relates to the technical field of medical care, aims at solving the problem that vaginitis is repeatedly caused since the traditional gynecological lotion kills many probiotics while killing pathogenic bacteria and causes vaginal flora imbalance and low vaginal immunity, and provides a gynecological vaginal lotion for adjusting the female vaginal micro-ecosystem and a preparation method thereof. The preparation method comprises the following steps: adding natural perfume having 0.01-0.5 percent of the volume concentration of acidic water into the acidic water, disinfecting, and adjusting the pH value to be 3.5-5.5. According to the method, lactobacillus reproduction is promoted to achieve the aim of inhibiting pathogenic bacteria, the absolute number of dominant bacterium lactobacillus is increased, the number of pathogenic bacteria is reduced, the micro-ecological balance of vagina is maintained, the vaginal cleanness is improved, the vagina mucosa immunity is improved, the gynecological vaginal inflammation is prevented, and the recurrence rate of gynecological vaginitis is reduced. The gynecological vaginal lotion is safe, has a specific pH value range being 3.5-5.5, and is safer and more effective than those of other bacteriostatic agents and bactericides.

The invention provides a vagina health probiotic composition. The vagina health probiotic composition comprises lactobacillus plantarum L-137 and at least one female probiotic, wherein the female probiotic is lactobacillus separated from the vagina or the urethra of a healthy female. The inactivated lactobacillus plantarum L-137 has the effect of promoting the growth of probiotics, especially thegrowth of the lactobacillus. The composition disclosed by the invention can recover vaginal flora, so that proliferation of harmful bacteria is inhibited, discomfort such as vaginal pain and itching and dryness can be relieved, peculiar smell is removed, the pH value is balanced, and the immune defense function of vaginal mucosa is enhanced. Vaginitis can be treated in an auxiliary manner; and thevaginitis can be prevented from happening and relapsing.

The invention studies the physiological action between vagina microorganisms and sperm cells with experimental means, and finds that certain vagina microorganisms can be specifically combined with sperms, so as to make sperms swim slower or even stop moving, or cause change in protein generation level of sperms to further affect the ability of sperms to be combined with eggs. Based on the findings, the invention determines a technical route for improving sperm motility by interfering with vaginal flora; microorganisms which can be well combined with sperms and do not affect basic physiological characters of sperms are selected out, adhesion of microorganisms harmful to sperms is prevented by means of the occupying function of the selected microorganisms, and therefore sperm motility can be improved, so as to relieve or treat infertility. Furthermore, probiotics microorganisms in a microbial agent are helpful for treatment of various diseases caused by vaginal flora dysbacteriosis, the treatment effect is remarkable, relapse probability is low, and popularization prospects are broad.

The invention discloses the technical field of female hygienic products, and particularly relates to a female bacteriostatic gel with an anti-cancer efficacy. The female bacteriostatic gel with the anti-cancer efficacy comprises the following raw materials in percent by weight: 7-8% of radix sophorae flavescentis, 5-7% of fructus cnidii, 5-6% of saffron, 4-6% of fructus kochiae, 4-5% of phellodendron amurense, 3-5% of sanguisorba officinalis, 3-5% of a pear juice fermented product and the like. Pear juice fermented by a lactobacillus fermenting agent contains a variety of organic acids, can repair a damaged vaginal environment and can adjust the pH value to facilitate the reproduction of commensal bacteria, so that the reproduction of harmful microorganisms is inhibited, vaginal florae restrict one another, the action of pathological bacteria is inhibited and the balance of the vaginal florae is restored; the pear juice fermented product provides a good environment for playing roles ofa variety of Chinese herbs, so that the bacteriostatic effect is better while the medicinal efficacy is rapid, and symptoms appearing in a female vagina can be quickly cured, and are prevented from further deteriorating to cause malignant diseases such as cervical cancer.

The invention relates to the technical field of pharmaceuticals and discloses a female probiotic composition and a preparation method and application thereof and a female care product. By the female probiotic composition, technical problems of low strain effective survival rate and poor colonization performance in the prior art can be solved, uncomfortable symptoms of female private parts can be effectively improved, vaginal pH value regulation is realized, and vaginal flora balance is recovered. In addition, the female probiotic composition has the advantage of effectiveness in improvement ofgynecological inflammations such as vaginitis, pelvic inflammation and cervicitis.