44 results about "Immune barrier" patented technology

The invention provides a composition for improving a barrier function and application thereof, and relates to the technical field of cell injury nursing. Gamma-aminobutyric acid (GABA) and cordyceps militaris fermentation filtrate (FCM) are used for treating barrier damage for the first time. Specifically, the combination of the gamma-aminobutyric acid and the cordyceps militaris fermentation filtrate can significantly improve damage of an epithelial mechanical barrier and an immune barrier caused by external stimulation, so that the epithelial barrier function can be prevented and improved from multiple dimensions.

The invention provides application of lactobacillus rhamnosus GOLDGUT-M520 or a composition of the lactobacillus rhamnosus GOLDGUT-M520 in preparation of a product for enhancing the immunity of an organism. The lactobacillus rhamnosus GOLDGUT-M520 has the function of enhancing the immunity in both a viable form and an inactivated form of the lactobacillus rhamnosus GOLDGUT-M520. The lactobacillus rhamnosus GOLDGUT-M520 has a good antibacterial capability on escherichia coli and staphylococcus aureus which are pathogenic to intestinal tracts, and is beneficial to enhancing a chemical barrier in an innate immune barrier; the strain can improve the phagocytic activity of macrophages and enhance the innate immune response; the strain can improve the T cell proportion, the B cell proportion and the immune globulin level in mesenteric lymph nodes of immunocompromised mice, and can enhance adaptive immune response. The lactobacillus rhamnosus GOLDGUT-M520 can comprehensively play a role in enhancing immunity, and meanwhile, the inherent immune barrier, the inherent immune response and the adaptive immune response are enhanced.

The invention provides a composition for promoting differentiation of intestinal immune cells as well as a preparation method and application of the composition. According to the composition, 1, 3-dioleic acid-2-palmitic acid triglyceride and breast milk oligosaccharide are used in a combined manner, so that monocytes can be effectively promoted to differentiate into intestinal macrophages, and inflammation is reduced to a certain extent. After the monocytes are differentiated into the intestinal macrophages, the intestinal immune homeostasis and intestinal microbiota inflammatory response can be regulated, so that the mucosal immune homeostasis and intestinal epithelial cell barrier function are maintained. Therefore, the composition provided by the invention can improve the intestinal immune barrier by promoting the monocytes to differentiate into the intestinal macrophages, and provides a new thought for improving the early intestinal barrier of infants through nutritional supplement.

The application discloses an active oxygen response type bacteriostatic and repair promoting hydrogel and a preparation method and application thereof, the hydrogel is formed by disulfide bond cross-linked hydrogel in response to active oxygen free radicals in the vagina of vaginitis patients through thiol modified hyaluronic acid (HASH), and can enhance in-vivo retention by thiol and vaginal tissue interaction. Cationic surfactant such as didecyldimethylammonium chloride (DDAC) as the bacteriostatic component of the hydrogel, efficiently killing pathogenic bacteria while having good biocompatibility, and is not prone to cause bacterial drug resistance. As a natural immune regulator, beta-glucan regulates the vaginal microenvironment, promotes the polarization of macrophages into anti-inflammatory M2 type and promotes cell migration, etc., to promote the repair of the vaginal immune barrier, regulate the vaginal flora, and reduce the probability of vaginitis recurrence. The HASH hydrogel provides an efficient, convenient and highly transformative potential strategy to provide more choices for the treatment of vaginitis.

The present application relates to the field of food technology, and specifically discloses a composition for reducing gastroesophageal reflux in individuals, a preparation method and application thereof. The composition for reducing gastroesophageal reflux in individuals comprises beta-defensin 1, lysozyme and lactoperoxidase. The present application constructs a multi-target synergistic intervention mechanism combining physical protection, secretion regulation and tissue repair through the compounding of four core components, which can comprehensively block the occurrence and development of gastroesophageal reflux. Lactadherin constructs a physical barrier to reduce the risk of reflux dynamics from the source; MLCT precisely regulates gastric acid secretion to reduce chemical stimulation; HMO complex IgG strengthens the mucosal immune barrier and promotes damage repair. The above composition is applied to products for reducing gastroesophageal reflux in individuals, and multi-target synergistic effect is achieved, realizing a full-chain closed-loop intervention from prevention, relief to repair, and significantly improving the clinical improvement effect.

The invention belongs to the technical field of foods, and particularly relates to a high-biological-activity muscle-building formula food for middle-aged and elderly people and a preparation method thereof. According to the high-biological-activity muscle-building formula food for the middle-aged and elderly people, the prepared mulberry leaf extract is added, the raw material raw milk is subjected to multi-stage membrane filtration to enrich beta-lactoglobulin, other auxiliary materials are adopted, muscle attenuation can be delayed, blood sugar can be remarkably reduced, sufficient nutrition support can be provided for the middle-aged and elderly people, and the high-biological-activity muscle-building formula food is suitable for the middle-aged and elderly people. The content of beta-lactoglobulin in the formula is not less than 3%, so that muscle health can be effectively improved, the immune barrier is improved, and functional decline is delayed.

The invention relates to a moisturizing and wrinkle fading composition and application thereof. The moisturizing and wrinkle fading composition is prepared from the following components: beta-glucan, dipalmitoyl hydroxyproline, butyrospermum parkii fruit fat unsaponifiable matter, sodium hyaluronate and soluble collagen. The beta-glucan, the dipalmitoyl hydroxyproline, the butyrospermum parkii fruit fat unsaponifiable matter, the sodium hyaluronate and the soluble collagen are creatively combined, and the beta-glucan can activate the skin immune barrier and create a stable environment for repairing; sodium hyaluronate and butyrospermum parkii butter unsaponifiable substances can maintain skin moisture and reduce dry wrinkles; the dipalmitoyl hydroxyproline can stimulate collagen regeneration, and the soluble collagen provides a repairing raw material at the same time, so that the effects of long-acting moisturizing and deep wrinkle fading are achieved. The five functional components cooperate with one another and have a synergistic effect, the moisturizing and wrinkle fading effects are jointly achieved, and the problems that lips are dry and wrinkles are likely to be generated can be better solved.

The present application belongs to the technical field of drug delivery, and relates to a sequential multi-stage targeted delivery system of a probiotic and prebiotic combination for repairing intestinal barriers. The delivery system is a microcapsule MP wrapped with NPs; the NPs are solid lipid nanoparticles formed by wrapping a probiotic with hyaluronic acid coupled small molecule acids as a film material; and the shell material of the microcapsule MP is a prebiotic. By wrapping the probiotic with hyaluronic acid coupled small molecule acids as a film material to form NPs, and then wrapping the NPs with a prebiotic wall material to form a microcapsule, the sequential multi-stage targeting and zonal release of different drugs can be achieved; the repair of the barrier will not have a reverse effect; the intestinal epithelial cell proliferation is promoted to repair the mechanical barrier; the intestinal flora abundance is improved to repair the microbial barrier; the mucus secretion is promoted to repair the chemical barrier; and the immune homeostasis is regulated to repair the immune barrier.

The invention provides a natural plant feed additive for improving immunity and promoting growth as well as a preparation method and application thereof, and relates to the field of feed additives, the natural plant feed additive is prepared from fourteen plant raw materials including gynostemma pentaphyllum, scandent hop, gentiana macrophylla, glossy privet fruit, flatstem milkvetch seed, sargentgloryvine stem, sea-buckthorn, astragalus membranaceus, radish seed, Chinese violet, humifuse euphorbia herb, ampelopsis japonica, paulownia flower and platycodon grandiflorum. The additive has multi-dimensional biological activity of promoting growth, enhancing immunity, resisting oxidation and protecting organs, can improve the growth performance of livestock and poultry by improving the average daily gain and reducing the feed-gain ratio to optimize the feed conversion rate, and can construct a humoral immune barrier by reducing the secretion of proinflammatory factors and increasing the level of anti-inflammatory factors to improve the immunity of livestock and poultry. According to the present invention, with the application of the composition, the protein and lipid metabolism disorder can be improved, the activity of ALT, AST and ALP can be reduced so as to protect the liver and the kidney and maintain the steady state of the body, the overall health level of livestock and poultry can be improved without the dependence on chemical agents, and the reliable technical support can be provided for promoting the development of the green, safe and efficient livestock and poultry breeding mode.

The invention discloses a modular combined vaccine soluble microneedle patch based on a mechanical interlocking tenon-and-mortise structure as well as a preparation method and application of the modular combined vaccine soluble microneedle patch. According to the combined and spliced micro-needle vaccine patch designed by the invention, synchronous delivery of various vaccines is realized by virtue of a micro-needle technology through fragmented loading and mechanical interlocking'mortise and tenon 'structural design, mutual interference among different vaccines is reduced at the same time, efficient protection can be provided for groups needing multi-vaccine protection by virtue of one-time inoculation, the number of inoculants is reduced, and the immune procedure is simplified; vaccine hesitation is reduced, and inoculation rate is increased; meanwhile, the biosoluble material of the microneedle structure can quickly release antigens in the skin to stimulate immune cells to aggregate so as to enhance the immune effect; the micron-sized needle array (lt; 500 m) acts on the superficial layer of the skin, is painless and can be designed into a self-adhesive patch, so that the inoculation compliance is improved; single-dose inoculation can also reduce medical cost, is suitable for resource-deficient regions, improves accessibility and burdenability, and accelerates establishment of a population immune barrier.

The invention belongs to the technical field of biological medicine, and particularly relates to a preparation method of a probiotic hydrogel material and application of the probiotic hydrogel material in treatment of acute radioactive intestinal injury. In order to solve the clinical key problem of radioactive intestinal injury, a novel biological material TG-CCS-coated DY802 of thiolated synchronously modified chitosan hydrogel TG-CCS loaded with'localized high-response 'lactobacillus salivarius DY802 is constructed. The synthesis process of the material is synergistic and time-saving, has excellent biological safety and tumor inhibition experiment performance, and can comprehensively repair four barriers of the intestinal tract: ROS is removed, and tight junction protein is protected to repair the physical barrier; forming a hydrogel protective layer to reinforce the chemical barrier; the flora diversity is improved, and the prebiotic effect is exerted to repair the biological barrier; the sphingomyelin metabolism and ceramide abundance are regulated and controlled, the abnormal infiltration of NK cells is inhibited, and the immune barrier is remodeled. Therefore, the probiotic hydrogel material disclosed by the invention is clear in treatment mechanism and remarkable in clinical transformation potential and application value.

The invention discloses a multi-target anticancer composition based on space-time controlled release and synergistic effect and a preparation method thereof, the composition is composed of three oral granules with synergistic functions: immune basic granules used for establishing an immune barrier; the targeted controlled-release particles are used for targeted release of the CD47 inhibitor and the flora prodrug in the intestinal tract; the space-time programming particle is used for carrying out in-vivo epigenetic editing under light control. Through dosage form design and a multi-level controlled release technology, time sequence and space precise treatment under oral administration is achieved, the medicine has the advantages of being high in synergy, high in targeting performance, good in safety and good in patient compliance, and a brand new solution is provided for radical treatment of cancers.

The invention belongs to the technical field of cosmetics, and particularly relates to a repairing composition containing camellia nitidissima extract microcapsules and application of the repairing composition. The repairing composition containing the camellia nitidissima extract microcapsules comprises the camellia nitidissima extract microcapsules, hydrolyzed royal jelly protein, chamomile extract, European foxtail millet leaf extract and magnolia sieboldii extract which have a synergistic effect, and the aim of barrier repairing can be achieved from multiple aspects of a physical barrier, an immune barrier, a microbial barrier and the like. The stability, the safety and the comprehensive effect of the composition are improved. According to the camellia nitidissima extract microcapsule disclosed by the invention, the camellia nitidissima extract is wrapped by using the inulin as a wall material, so that the thermal stability can be enhanced, water absorption and moisture retention of skin can be effectively promoted, the problems of skin dryness, tightness and the like can be relieved, harmful bacteria can be inhibited, and the growth of beneficial bacteria can be promoted. The composition provided by the invention also has the advantages of being simple and convenient in preparation method, suitable for industrial production and the like, can be applied to preparation of repair cosmetics, and has better market application value.

The invention belongs to the field of cosmetics, and particularly relates to a synergistic repair composition for sensitive skin multi-barrier damage and application of the synergistic repair composition. The invention relates to a synergistic repair composition aiming at damaged multiple barriers of sensitive skin. The synergistic repair composition comprises the following components in parts by weight: 10-25 parts of a physical barrier functional component, 3-10 parts of an immune barrier functional component, 3-10 parts of a microbial barrier functional component and 56-84 parts of a solvent. According to the technology, starting from a skin barrier damage mechanism, through screening and scientific matching of the functional components, the synergistic interaction effect of repairing the damaged skin barrier is generated among the components while the self effects of the functional components are fully exerted.

The invention discloses a composite peptide premix feed capable of improving immunity of livestock and poultry aquatic products and a preparation method thereof, and relates to the technical field of feeds. In order to reduce the use amount of antibiotics in the livestock breeding process, a composite peptide component is added into the premix feed, and the use amount of the antibiotics is reduced by adding bovine lactoferrin peptide in the premix feed. Macrophages and natural killer cells are activated, immune globulin secretion is promoted, and the mucosal immune barrier function is enhanced, so that the autoimmunity of livestock is improved, and the disease resistance of the livestock is improved; and in order to avoid the defect that the feed is easy to mildew to generate mildew toxins, mildew-proof modified attapulgite clay is also prepared and added, so that the mildew speed after the premixed feed and the feed are mixed and watered is effectively slowed down, and the diarrhea rate of livestock is reduced.

The application discloses a Bifidobacterium longum subsp. longum strain for regulating intestinal homeostasis and relieving intractable constipation and an application thereof, and belongs to the field of microorganisms. The strain CCFM1319 provided by the application can shorten the time of the first black stool of intractable constipation mice, significantly enhance the colon peristalsis ability of the intractable constipation mice, increase the expression level of the characteristic marker of enteric glial cells in the colon tissue, repair the intestinal nerve damage caused by intractable constipation, reduce the expression level of inflammatory factors in the colon tissue of the intractable constipation mice, relieve the inflammation of the intestinal immune barrier, reduce the pathological damage of the colon tissue, increase the expression amount of the tight junction protein in the colon tissue, repair the damage of the intestinal mechanical barrier, avoid excessive water absorption, be beneficial to the excretion of feces, regulate the intestinal chemical barrier, improve the intestinal microecological imbalance, make the intestinal flora structure tend to be healthy, and repair the damage of the intestinal biological barrier, so as to play a role in comprehensively relieving intractable constipation.

The invention provides a sensitive skin barrier repairing composition as well as a preparation method and application thereof, and belongs to the technical field of cosmetics. Comprising the following components in percentage by weight: 1.5-5% of a polysaccharide component, 0.0001-0.01% of a peptide component, 0.1-1% of a carotenoid component, 3-10% of an unsaturated fatty acid component, 1-3% of an algae extract component and the balance of a matrix component, totaling 100%. The sensitive skin barrier repairing composition prepared by the invention systematically repairs a physical barrier, a chemical barrier, an immune barrier and a micro-ecological barrier of skin by simultaneously acting on a plurality of biological targets related to sensitive skin, so that uncomfortable symptoms such as skin redness, pruritus, scorching hot and the like are efficiently relieved.

The invention relates to the technical field of biological medicine and vaccine preparation, and discloses a preparation method of a tetravalent influenza virus split vaccine, and the preparation method comprises the following steps: inoculating four influenza viruses into a chick embryo, culturing, harvesting allantoic fluid, and concentrating; centrifugally purifying through a sucrose density zone, and adding a cracking agent for cracking; removing the cracking agent from the cracking solution through chromatographic column chromatography, and then adding an inactivating agent for inactivating and removing the inactivating agent; according to the method disclosed by the invention, a process route of firstly splitting purification and then inactivation in combination with dual purification of centrifugation and chromatography is adopted, so that the problem of impurity cross-linking caused by an inactivator in a traditional process is effectively avoided, and residues of ovalbumin and splitting agents are deeply removed; and the natural conformation of the virus antigen is retained to the greatest extent. The obtained vaccine is extremely low in impurity content, has excellent safety and high immunogenicity, and can effectively expand the immune protection range and enhance the population immune barrier.

The invention relates to the technical field of biological medicines, in particular to an ATP (adenosine triphosphate) response type multifunctional DNA (deoxyribonucleic acid) immune nano-drug as well as preparation and application thereof. The ATP response type multifunctional DNA immune nano-drug provided by the invention has a DNAzyme nano-structure with a cascade response function, and a gene therapy module and an immune therapy module are organically integrated into the same delivery system; accurate drug controlled release can be achieved, and the targeted accumulation efficiency of tumor tissue is remarkably improved; and meanwhile, by integrating DDR1 gene silencing and immune regulation functions, two key links of a tumor physical barrier and an immune barrier are synergistically acted. The multi-target collaborative intervention strategy not only effectively improves the permeability of the medicine in the tumor tissue, but also enhances the therapeutic response by remodeling the tumor immune microenvironment.

The invention belongs to the technical field of microorganisms, and particularly relates to a genetic transformation method aiming at Huiarenaceae microflora and application of the genetic transformation method. Specifically, a genetic transformation method aiming at Huiarenaceae microbe is established for the first time, exogenous plasmids are subjected to in-vitro methylation modification by using methylase in a cell-free system of the strain, and the activity of endonuclease is inhibited in combination with a combination mode of ATP consumption and EDTA chelation; the problem of exogenous plasmid degradation caused by a complex and unknown strain limitation modification system is effectively solved, and the immune barrier is successfully broken through. Meanwhile, by optimizing competent cell preparation conditions and electrotransformation parameters, the transformation efficiency reaches an operable level, and the requirements of molecular operation are met. The invention provides a key technical support for molecular modification of Huiaromatic Zhongaceae microflora, is helpful for excavating the metabolic potential of the Huiaromatic Zhongaceae microflora, improves the stress resistance, and promotes the industrial application of the Huiaromatic Zhongaceae microflora in the field of environmental governance such as combined pollution wastewater treatment.

The invention discloses an arteannuyl sphingosine base derivative as well as a preparation method and application thereof. The arteannuyl sphingosine base derivative provided by the invention is prepared by carrying out molecular modification on an arteannuic acid compound and a sphingosine base compound and carrying out amidation reaction. The derivative combines the biological activities of the two, enhances skin affinity, stability and functionality, has excellent multiple activities of resisting inflammation, relieving, improving skin immune barrier, resisting wrinkles and the like, can be used for improving the skin barrier function, relieving inflammatory response and delaying skin aging, and can be used for preventing and treating skin aging. The method can be widely applied to preparation of skin care products, cosmetics, hair supplies and daily chemical external preparations, and has good application prospects and market value. Meanwhile, the preparation method provided by the invention is mild in condition, high in reaction efficiency, environment-friendly and suitable for industrial production, and a raw material basis is provided for preparing more products for improving the skin barrier function, relieving inflammatory response and delaying skin aging.

This disclosure presents a kit for detecting the tumor immune barrier and its application. The kit includes: a first detection reagent that specifically recognizes POSTN protein for labeling POSTN⁺ cancer-associated fibroblasts; and a second detection reagent that specifically recognizes APOE protein for labeling APOE⁺ tumor-associated macrophages. The spatial co-localization characteristics of POSTN⁺ cancer-associated fibroblasts and APOE⁺ tumor-associated macrophages in tumor tissue indicate the presence of the tumor immune barrier. This disclosure achieves high-throughput, automated, and quantitative assessment of the complex spatial structure of the tumor immune barrier (TIB), significantly reducing subjective errors in pathological interpretation and demonstrating good operability and clinical application prospects.

The present application relates to the field of food technology, and specifically discloses a composition for reducing gastroesophageal reflux in individuals, a preparation method and application thereof. The composition for reducing gastroesophageal reflux in individuals comprises lactadherin, medium-long chain triglyceride, human milk oligosaccharide and immunoglobulin G. The present application constructs a multi-target synergistic intervention mechanism combining physical protection, secretion regulation and tissue repair through the compounding of four core components, which can comprehensively block the occurrence and development of gastroesophageal reflux. Lactadherin constructs a physical barrier to reduce the risk of reflux dynamics from the source; MLCT precisely regulates gastric acid secretion, reducing chemical stimulation; HMO compound IgG strengthens the mucosal immune barrier and promotes damage repair. The above composition is applied to products for reducing gastroesophageal reflux in individuals, and multi-target synergistic effect is achieved, realizing the whole-chain closed-loop intervention from prevention, relief to repair, and significantly improving the clinical improvement effect.

The invention discloses a feed for enhancing heavy metal cadmium stress resistance of juvenile carp. The feed is prepared from the following raw materials in percentage by weight: 8% of fish meal, 5% of chicken meal, 30% of soybean meal, 4% of chlorella, 6.5% of cottonseed protein concentrate, 4.5% of zeolite powder, 6.98%-8.98% of microcrystalline cellulose, 0%-2% of sodium silicate, 10.19% of flour, 15% of cassava starch, 2.04% of fish oil, 2.04% of soybean oil, 0.5% of choline chloride, 1.75% of monocalcium phosphate, 0.4% of vitamin premix, 0.6% of trace element premix, 0.05% of allicin, 0.12% of lysine and 0.33% of methionine. By adding a proper amount of sodium silicate into the feed, the carps under heavy metal cadmium stress can be protected, the intestinal oxidative stress of the carps under the heavy metal cadmium stress is relieved, and the immune barrier is enhanced.

This invention discloses an engineered probiotic outer membrane vesicle vaccine co-expressing multiple antigens of monkeypox virus, its preparation method, and its application. The outer membrane vesicle vaccine is based on... lpxm Using the gene-deleted probiotic Escherichia coli Nissle 1917 as the host, ABM@OMV was constructed by genetically engineering and co-expressing and displaying three key monkeypox virus antigens, A9R, B6R, and M1R, on the surface of its secreted outer membrane vesicles. Leveraging the natural adjuvant and highly efficient mucosal delivery characteristics of OMV, combined with a multi-antigen synergistic strategy, nasal immunization can simultaneously activate strong systemic humoral immunity (high-titer neutralizing IgG) and cellular immunity (CD4+). + / CD8 + T cells are involved in the vaccine, which induces high levels of specific sIgA antibodies in the respiratory and distal genital tract mucosa, forming an effective immune barrier. Challenge experiments showed that the vaccine completely protects mice from lethal doses of vaccinia virus, significantly reduces tissue damage, and provides a novel solution for preventing monkeypox virus transmission via mucosa.

The invention discloses application of an FMR1 inhibitor in preparation of a medicine for treating immunological rejection type gastric cancer. Experimental studies prove that FTO is continuously and highly expressed in immunological rejection phenotypes and is related to interstitial activation and T cell rejection. Continuous immunohistochemistry and multiple immunofluorescence show that the FMR1 protein is highly expressed in an immunological rejection type tumor microenvironment, and most CD8 + T cells are located in tumor interstitial substances. In mechanism, the FMR1 regulates and stabilizes FTO protein and limits the degradation of proteasome of the FTO protein through post-translation, so that FTO-dependent m6A reprogramming is maintained, and an immunological rejection microenvironment is enhanced. Therefore, the invention discloses a non-classical mechanism that the FMR1 modifies and stabilizes the FTO protein after translation, and the FMR1-FTO axis can be used as a potential intervention target for breaking an immune barrier and sensitizing gastric cancer immunotherapy.

The application of recombinant ultra-high molecular weight hyaluronic acid in regulating intestinal immunity in colitis belongs to the field of biomedical technology. This invention addresses the limitations of existing treatments for inflammatory bowel disease (IBD), which suffer from limited efficacy, significant side effects, and difficulty in targeting and repairing the intestinal immune barrier. It provides the application of recombinant ultra-high molecular weight hyaluronic acid in regulating intestinal immunity in colitis. This recombinant ultra-high molecular weight hyaluronic acid can activate the intestinal IgA-producing immune network, regulate inflammation-related genes, and repair the physical and immune barriers of the colonic mucosa, thus exhibiting a superior protective effect against colitis compared to conventional hyaluronic acid, providing a new candidate drug for the treatment of IBD.

The invention belongs to the technical field of biological medicines, and particularly relates to acacetin-containing lipid nanoparticles for a pulmonary inhalation type mRNA vaccine as well as a preparation method and application of the acacetin-containing lipid nanoparticles. The lipid nano-particle takes acacetin as a functional fifth component, is jointly composed of ionized lipid, neutral auxiliary lipid, cholesterol and polyethylene glycol lipid, and can effectively wrap mRNA (messenger Ribonucleic Acid) of an encoding antigen. According to the preparation method, high-efficiency compounding of lipid and mRNA is realized through a microfluidic technology, the particle size of the obtained particles is adaptive to lung targeting, alveolar macrophage removal can be reduced, mRNA is protected from peroxidation damage, and vaccine response is enhanced through the immunomodulatory effect of acacetin. The system can be prepared into a lung inhalation type mRNA vaccine, is used for preventing and controlling respiratory tract infectious diseases, has high-efficiency delivery, strong immunization and good safety, and provides a new scheme for construction of a lung immune barrier.

The invention provides an application of fructus psoraleae polysaccharide in preparation of a medicine or health food for regulating an intestinal barrier function. Specifically, the fructus psoraleae polysaccharide acts on an intestinal tract. In the intestinal tract action process, the fructus psoraleae polysaccharide effectively improves damaged intestinal tract barrier repair; the number of CD4 + and CD8 + T cells in intestinal tracts is increased, and the immune barrier of the intestinal tracts is improved; according to the present invention, the expression of tight junction proteins Claudin-1, Occludin and ZO-1 can be promoted, the intestinal mechanical barrier can be repaired and enhanced, and the polypeptide can be used for preventing, relieving or treating intestinal barrier damage, has excellent performance in the regulation of the intestinal barrier function, and has good application prospects.

The application belongs to the field of daily chemicals, and discloses a composition with improved skin self-protection, which comprises the following components: 6-8 wt% of a phosphoric group modified lactoferrin solution; 1.2-1.5 wt% of an alginate oligosaccharide; 1-2 wt% of plant oil with skin barrier repair function; emulsifier; and the balance of water; the concentration of the phosphoric group modified lactoferrin in the phosphoric group modified lactoferrin solution is 1.2-2 wt%. The composition uses the phosphoric group modified lactoferrin to improve the repair effect of the alginate oligosaccharide and the functional plant oil on the skin, and the composition can not only relieve the dry skin function, but also improve the physical barrier and immune barrier functions of the skin, and improve the self-protection ability of the skin. Another purpose of the application is to provide the application of the composition.