The invention discloses a Chinese medicine composition for treating and preventing chronic hepatic fibrosis and liver cirrhosis (wormwood-turtle yin-nourishing hardness-softening prescription), which comprises medicinal materials or active extracts thereof used as active ingredients, and a medicinal carrier. The Chinese medicine composition comprises 0.01-50 portions of sweet wormwood, 6-75 portions of turtle shell, 6-75 portions of radix rehmanniae, 6-50 portions of rhizoma anemarrhenae, 6-75 portions of radix salviae miltiorrhizae, 6-75 portions of giant knotweed, 6-75 portions of oldenlandia, 6-50 portions of radix curcumae and 6-50 portions of boneset. The wormwood-turtle yin-nourishing hardness-softening prescription composition of the invention has the functions of promoting blood circulation, resolving the hard lumps, nourishing yin, removing heat from the blood, clearing away heat, promoting diuresis and removing toxicity. The pharmacodynamic experimental result indicates that the Chinese medicine composition has the characteristics of high cure rate and obvious effect on hepatic fibrosis and liver cirrhosis caused by many reasons, such as chronic viral hepatitis, schistosomiasis, long-term drinking, chemical poisoning and the like. The Chinese medicine composition has favorable application prospects and is worthy of clinical popularization and application.