782results about How to "Improve response rate" patented technology

The invention provides an mVSV virus vector, i.e., attenuated mVSV obtained after multiple modification mutations occur to an M protein amino acid site of a wild Indiana strain VSV, and an optimized heterologous antigen gene is preferentially integrated to a double cloning site area of an mVSV packaging core plasmid pmVSV-Core at the same time. The mVSV virus vector vaccine comprises a heterologous antigen gene which fuses or embeds a target virus between G and L genes of an mVSV vector envelope, wherein the antigen gene comprises an enveloped and embedded antigen gene encoding the target virus, an embedded combination antigen gene or a fused antigen gene; the mVSV virus vector is embedded or fused with a dominant antigen of spike protein S of an SARS-CoV-2 pathogen; the dominant antigen is preferably selected from a receptor binding domain of spike protein S, namely RBD; and a COVID-19 vaccine based on mVSV mediation is formed. The vaccine has good prevention or treatment effect on COVID-19 infected people.

The present invention provides antibodies that bind to the IL-3 receptor alpha subunit alpha (Il3Rα) chain, and compositions comprising such antibodies. The present invention provides methods for inhibiting or reducing an IL3Rα-expressing cell population, the methods comprising contacting a population of IL3Rα-expressing cells (e.g., cancer cells and / or cancer stem cells) with an antibody that binds to IL3Rα. The present invention also provides antibody conjugates comprising an antibody that binds to an IL3Rα chain linked to a cytotoxic agent or anticellular agent and compositions comprising such conjugates. The present invention also provides methods for preventing, treating and / or managing a disorder associated with IL3Rα-expressing cells (e.g., a hematological cancer), the methods comprising administering to a subject in need thereof an antibody that binds to IL3Rα.

The present invention relates to a question recommendation method, device and system. The method comprises: according to a short-term interest, a long-term interest and a crowd interest of a user, a server constructing an interest vector of the user, the interest vector of the user comprising a plurality of interest entries; according to the plurality of interest entries, acquiring a candidate recommendation question from a set of questions to be solved; according to a click rate model, predicting the probability of the user answering the candidate recommendation question, and according to the predicted probability, selecting a question to be recommended; and recommending the question to be recommended to a client. In this way, a real-time and comprehensive recommendation result can be obtained, and the rate for answering questions of an interactive question and answer platform can be increased as well.

The invention provides an infrared detector of a microbridge structure and a method for manufacturing the infrared detector of the microbridge structure. The detector comprises a reading circuit substrate, a microbridge leg, a heat sensitive layer, an infrared reflection layer and an infrared absorption layer. The infrared absorption layer is supported by and arranged above the heat sensitive layer, a resonant cavity for incoming infrared light is formed by the infrared absorption layer and the infrared reflection layer, and the microbridge leg is arranged below the infrared reflection layer and electrically connected with the reading circuit substrate. Through the structure, the infrared absorptivity of the device can be improved while thermal conductance of the device can be reduced, the filling rate of the device is improved, the defects of the resonant cavity are overcome, and thus the thermal isolation effect and the responsivity of the device are improved and the performance of the device is optimized.

The invention discloses a system and method for task processing. The system comprises a request receiving module, a task splitting module, a task processing module, a result integration module and a result returning module. According to the characteristic that historical data of a real-time database are managed through a non-shared mechanism in the prior art, a shared management mechanism is adopted in the system. A query task requested by a user is split into a plurality of sub-tasks by various functional modules of the system on the basis of a preset splitting strategy. Parallel processing is conducted on the sub-tasks on the basis of a data source shared mechanism. When the method is specifically implemented, a plurality of database servers can be arranged to serve as equal nodes to be connected to the real-time database, so that a data access right of the real-time database is shared. Parallel access is conducted on the real-time database, so that the sub-tasks are processed in parallel. Compared with an existing task processing method based on the non-shared management mechanism, the inquiry performance of the real-time database is greatly improved through the system and method for task processing.

A bymixer device and method which provides fast-response, accurate measurements of mixed inspired and / or expired gas fractions in open or closed ventilation circuits and / or in circle circuits used in anesthesia and / or critical care. The bymixer device may include a main flow channel and a bypass flow channel. The bypass flow channel includes a flow-restrictor (e.g, an orifice) that partially blocks the flow of respiratory gas through the bypass flow channel, a mixing chamber positioned upstream of the flow restrictor and a sampling apparatus (e.g., a port for withdrawing samples of gas from said mixing chamber and / or sensor(s) positioned within the mixing chamber).

An embodiment of the invention discloses a webpage loading method. The webpage loading method includes: a server sends a webpage request to a server and loads an overall frame of a requested webpage returned by the server, and first screen content of the requested webpage is loaded to corresponding position of the overall frame; the browser displays the first screen content, and the frame with all or part of the first screen content loaded enters a visible region of the browser; when the frame in the visible region changes, and the browser determining a need of loading of new content in the frame in the current visible region sends an acquisition request to the server to request acquisition of the new content to be loaded; and the browser loads the new content returned by the server at the corresponding position of the overall frame and displays the new content in the current visible region. The embodiment of the invention further discloses a server, a terminal and a webpage loading system. The webpage loading method, the webpage loading system, the browser, the terminal and the server can load webpages dynamically according to users' requests, and accordingly webpage response rate is increased.

The invention relates to a preparation method of a micro-bridge structured infrared detector, and a micro-bridge structure. The method comprises the steps that: a metal reflective layer and a sacrificial layer are sequentially deposited on an infrared detector readout circuit substrate; PI holes are etched on the sacrificial layer, wherein the PI holes are positioned at an out-leading electrode of the readout circuit; a deposition support layer, a thermo-sensitive layer and a protective layer are sequentially deposited on the sacrificial layer; through holes are prepared in the PI holes, and a contact hole is prepared on the protective layer; electrode layer metal is deposited on the protective layer, and U-shaped metals with bridge pier structures are filled in the PI holes and the through holes; and U-shaped metal structures are formed through photolithography and etching; photolithography and etching is carried out upon the electrode layer metal; a passivation layer is deposited on the surface of the device, and the passivation layer is subjected to photolithography and etching, such that a passivation layer pattern is formed; and sacrificial layer releasing is carried out, such that the micro-bridge structure is formed. According to the invention, a U-shape filling method is adopted, and Al is adopted as a filling material. Therefore, sputtering and depositing are easy, and etching is convenient. The heat insulation property of the detector is better than that of a copper filling process, and a CMP step is not needed.

The invention discloses hydrogel photonic crystal microspheres, and a preparation method and an application thereof. The preparation method comprises the steps of (1) preparation of silica emulsion droplets, (2) preparation of silica photonic crystal microspheres, (3) preparation of silica-hydrogel hybrid photonic crystal microspheres, and (4) preparation of inverse-opal-structured hydrogel photonic crystal microspheres. In the step (3), acrylamide, acrylic acid, methylene bisacrylamide and a photo-initiator are allowed to penetrate into the silica photonic crystal microspheres; ultraviolet irradiation is carried out, such that acrylamide and acrylic acid monomers are cured, such that the silica-hydrogel hybrid photonic crystal microspheres are obtained. With the method provided by the invention, the obtained hydrogel photonic crystal microspheres have a three-dimensional ordered porous structure, wherein the pores have a compact hexagonal stacking ordered structure. With the method, technical problems of angle dependence and slow response to small molecules of existing hydrogel photonic crystal films can be solved.

The invention provides a combination comprising an ancillary compound and a compound having the formula (0): or salts or tautomers or N-oxides or solvates thereof; wherein X is a group R1-A-NR4— or a 5- or 6-membered carbocyclic or heterocyclic ring; A is a bond, SO2, C═O, NR9(C═O) or 0(C═O) wherein R9 is hydrogen or C1-4 hydrocarbyl optionally substituted by hydroxy or C1-4 alkoxy; Y is a bond or an alkylene chain of 1, 2 or 3 carbon atoms in length; R1 is hydrogen; a carbocyclic or heterocyclic group having from 3 to 12 ring members; or a C1-8 hydrocarbyl group optionally substituted by one or more substituents selected from halogen, hydroxy, C1-4 hydrocarbyloxy, amino, mono- or di-C1-4 hydrocarbylamino, and carbocyclic or heterocyclic groups having from 3 to 12 ring members, and wherein 1 or 2 of the carbon atoms of the hydrocarbyl group may optionally be replaced by an atom or group selected from O, S, NH, SO, SO2; R2 is hydrogen; halogen; C1-4 alkoxy; or a C1-4 hydrocarbyl group optionally substituted by halogen, hydroxyl or C1-4 alkoxy; R3 is selected from hydrogen and carbocyclic and heterocyclic groups having from 3 to 12 ring members; and R4 is hydrogen or a C1-4 hydrocarbyl group optionally substituted by halogen, hydroxyl or C1-4 alkoxy.

A computer network implemented peer forum system and method enabling question and answer rates to be increased by automatically routing questions and receiving answers to and from peers. Information is input into network via a user interface. A peer forum system enables users to ask and answer questions. A forums database captures questions and answers provided via the peer forum system. A stage database pulls and stores questions from the forums database. A question router pulls the questions from the stage database and finds peers who can answer the questions using a peer search module that uses implicit and explicit user profiles to determine the best subject matter experts to answer the questions. A set of throttle rules is associated with the question router for determining if a peer is eligible to answer a question. A delivery system delivers a communication to eligible peers requesting an answer to the question.

The invention relates to an answer extraction method for a tourism question and answer system based on ontology reasoning, which belongs to the field of artificial intelligence. The answer extraction method for the tourism question and answer system based on ontology reasoning is characterized in that: firstly, semantic rules in the field are defined, an artificial ontology knowledge base is constructed, and question sentences of users are analyzed; secondly, answer extraction is performed by combing semantic rule-based reasoning and information retrieval, instead of simple matching; and thirdly, corresponding answer extraction algorithms are designed according to different question sentence types. The invention provides the answer extraction method for the tourism question and answer system based on ontology reasoning, which introduces the ontology concept into construction of the knowledge base of the question and answer system, uses an OWL (Ontology Web Language) ontology descriptive language to clearly and definitely represent concepts, attributes and relations in the field of tourism, and more effectively organizes knowledge. In an open test, the precision of answers of the question and answer system based on ontology reasoning to 1346 natural language questions of the users reaches 81.35 percent, and the recall rate reaches 90.49 percent.

The invention discloses an information external network, an information internal network, and a system and a method for data interaction between the internal network and the external network. In the method, the information external network receives and processes a plurality of pieces of request information concurrently sent by a user, carries out data penetration with the information internal network on the basis of the interaction mode of concurrent processing, and concurrently sends a plurality of request instructions processed to a preset language form and a preset format to the information internal network through physical isolation equipment, the information internal network concurrently processes the plurality of request instructions to acquires the corresponding response result data, and finally the information external network acquires the result data and concurrently displays the result data to the related positions of an application system. During specific implementation, concurrent data interaction and processing processes can be realized by an asynchronous thread pool, an advanced queue and the like, hence, by differing from the existing interaction mode based on polling processing, in the method disclosed by the invention, the data penetration of the internal network and the external network is realized on the basis of concurrent processing, thus improving the performance of the data interaction of the internal network and the external network, and increasing the response speed of user requests.

The invention relates to the field of an infrared detector, in particular to a micromachined thermopile infrared detector. The manufacturing technique is simplified and the performance and finished product rate are improved. The manufacture of the micromachined thermopile infrared detector comprises the following steps of: (1) depositing silicon nitride film on the both sides of a silicon substrate by an LPCVD method; (2) etching to remove peripheral silicon nitride film on the frontal side of the silicon substrate by lithography; (3) manufacturing a plurality of Poly-Si strips both ends of which are respectively arranged on the silicon nitride film and the silicon substrate by LPCVD method and photolithographic process; (4) manufacturing a plurality of aluminum strips which form a thermocouple with the plurality of Poly-Si strips by sputtering and photolithographic processes; (5) depositing the silicon nitride film on the frontal side of the silicon substrate by PECVD method; (6) manufacturing an infrared absorption layer (a carbonized photoresist layer) covering the hot junction area of the thermopile with photolithographic process; (7) manufacturing a metal reflective layer (a metal layer) covering the cold junction area of the thermopile with lift-off process; and (8) eroding the back side of the silicon substrate to form a square frustum pyramid shaped groove. The micromachined thermopile infrared detector has reasonable structure design, simple manufacturing process, high detector performance, high finished product rate, good development prospect and is easy to realize.

The invention provides a thermopile infrared detector and a manufacturing method of the thermopile infrared detector. The thermopile infrared detector comprises a substrate, a dielectric supporting film, a thermopile, a metamaterial structure, a middle dielectric layer and a metal micro structure layer, wherein a cavity is formed in the substrate, the dielectric supporting film is located above the cavity and supported by the substrate, the thermopile is located on the dielectric supporting film above the cavity, the metamaterial structure is located above the thermopile and comprises a metal plane reflecting mirror, the middle dielectric layer is located on the metal plane reflecting mirror, the metal micro structure layer is located on the middle dielectric layer and comprises one or more structural period units, and each structural period unit comprises one or more geometric figure units having the light adsorption enhance effect within the infrared spectrum range. Due to the thermopile infrared detector, perform absorption within the infrared band broad spectrum range can be achieved, the infrared adsorption rate and the responding rate of the thermopile infrared detector can be improved, and the manufacturing method is compatible with a conventional CMOS technology.

The invention provides a heat exchanger. The heat exchanger comprises a pipe pass side and a shell pass side; the pipe pass side includes an inlet pipe, an inlet cavity, a heat transfer pipe bundle, an outlet cavity and an outlet pipe; a hot fluid enters the inlet cavity from the inlet pipe to pass through the heat transfer pipe bundle, the outlet cavity and the outlet pipe in sequence; the shell pass side includes an inlet channel, an inner shell, an outer shell and an outlet cavity; a cold fluid passes through space limited by the inlet channel, the inner shell and the outer shell and the outlet cavity in sequence; the inlet cavity, the heat transfer pipe bundle and the outlet cavity are arranged in space limited by the inner shell and the outer shell; a metal rod outwards extends from the outer wall of the heat transfer pipe bundle; the end part of the metal rod is a sharp structure; and the direction from the outer wall of the heat transfer pipe bundle to the end part of the metal rod is opposite to the flowing direction of the cold fluid. The rod with the sharp end part is arranged at the external of the heat exchange pipe; in flowing of a gas-liquid two-phase flow, on the one hand, the laminar flow bottom layer can be broken, and the heat transfer area is increased for forced heat transfer; because of the rod, the flowing resistance is low, and the shell pass flowing resistance cannot be increased; and as the sharp end part is provided, bubbles can be punctured to realize increment of a gas-liquid interface and a gas-phase boundary layer and reinforcement of the disturbance.

The invention provides a sports field booking system based on an internet and a booking treatment method thereof. An internet system architecture consists of a booking service server and a user client end, the characteristics of easy popularization and quick information and communication propagation of the internet are utilized, the resources of the sports field provided by a sports field supplier are integrated, the persons who have the same hobby on the same sports item are helped to gather and participate, the integral service is provided for the person organization and field booking of the sports item, and the organization of the sports participation persons and the ordering transaction of the field are helped and promoted; simultaneously, the user operation of the sports field booking is much simplified, the booking is more timely, the problems of trouble, booking delay and the like caused by the user firstly organizing the persons and then arranging the sports field are solved, the problem of difficulty in person organization and sports filed leasing when the persons develop the sports item is solved, the activity of the persons actively participating in the sports is improved, and the good development of national fitness is favorably promoted.

This invention discloses one infrared detector structure and process method based on micro mechanic bridge resonance device, wherein the detector is composed of bridge resonance chip and cover board through vacuum sealing technique or gas sealing technique; the incidence infrared line is to micro mechanic bridge surface through infrared incidence window to lead the bridge temperature rise and to add axis stress force and to lower resonance frequency to reflect incidence infrared strength.

This invention provides a preparation method of vanadium oxides film whose phase change temperature is variable. Siliconoxide film and silicon nitride film deposit on the silicon slice. The method of ion beam reactive sputtering is used to deposit vanadium oxide film. The processing conditions as followings: back bottom vacuum 4X10-4Pa-3X10-3Pa, oxygen pressure 6X10-4Pa-8X10-3Pa, argon gas pressure: 1X10-2Pa-2.3X10-2Pa,ion beam power: 8W-60W, substrate temperature: 120deg.C-450deg.C, sputter time: 10-45min, the vanadium target is butt material. The annealing treatment is for the sample. The processing conditions gas: argon or nitrogen gas, annealing temperature: 250deg.C-580deg.C, annealing time: 20-240 min, and then getting phase change vanadium oxide film.

The invention discloses an uncooled infrared focal planedetector pixel and a preparation method thereof, and belongs to the technical field of uncooled infrared focal planedetectors. The uncooled infrared focal planedetector pixel sequentially comprises three layers of structures from a semiconductor substrate to the top; the bridge leg structure on the first layer comprises a metal reflection layer, an insulation dielectric layer, a first support layer, a first support layer protection layer, a first metal electrode layer and a first silicon nitridedielectric layer; the thermal conversion structure on the second layer comprises a second support layer, a second support layer protection layer, a thermosensitive layer, a thermosensitive layer protection layer, a second metal electrode layer and a second silicon nitridedielectric layer; the absorption layer structure on the third layer comprises a third support layer, an absorption layer and an absorption layer protection layer. The invention further discloses the preparation method of the novel uncooled infrared focal planedetector pixel. According to the uncooled infrared focal planedetector pixel,absorptivity of infrared radiation can be significantly increased, responsivity of a detector is increased, and a foundation is laid for manufacturing detectors which are larger in array and smaller in pixel.

The invention is applicable to the technical field of internet technology, provides a question recommending method and a question recommending system both in a questions-and-answers community. The method includes the following steps: matching a question keyword list of a to-be-recommended question with a preset weighted question keyword list of each user to acquire a weight sum of successfully-matched question keywords corresponding to each user, matching the question keyword list with preset weighted field keyword lists of each user to acquire a maximum value of a weight sum of successfully-matched field question keywords corresponding to each user, combining the weight sum of the successfully-matched question keywords corresponding to each user and the maximum value of the weight sum of the field question keywords to acquire relevancy of the to-be-recommended question and a user, and pushing the to-be-recommended question to one or more users with highest relevancy to improve answering rate of the users to the questions in the questions-and-answers community and improve user experience effect.

The invention discloses a crossed combinational dual-period grating for quantum well infrared detector. By arranging two sizes of gates across, the invention responses to two wave bands and acquires the information of the two wave bands. The cross array makes a very good response uniformity of the new-type gates on the whole surface, and the two types of gates are distributed as the Chinese character 'pin', which makes the photolithography linewidth up to the maximum and thereby enhances the precision of photolithography patterns. The square gate hole is used to prevent astigmatism; the optimized parameter design enhances the coupling efficiency of the gates. The invention is applied to dual-color quantum well infrared detectors, is able to acquire the objective information more accurately in two wave bands simultaneously, more effectively inhibits the complicate background, and then enhances the detecting effect of objectives. The invention has the advantages of simple fabrication, low cost, and easy realization of mass and serial production.

The invention discloses a reconfigurable optical add-drop multiplexer (an ROADM structure) for realizing 16 channels with multiple orders. The ROADM structure comprises an input part, a first-order filtration area, a second-order filtration area, a local download area, a combiner and an output part which are connected through nanometer wire waveguides. The ROADM structure has a certain width by utilizing the free spectral width of a micro-ring resonator and filters a plurality of paths of incident wavelengths with respective orders so as to ensure that the wavelength number in each download waveguide is reduced progressively and finally realize the single wavelength download in each output port, thereby reducing the temperature control difficulty and improving the response speed of devices.

A combination comprising (a) a compound of formula (0): or salts or tautomers or N-oxides or solvates thereof; wherein X is R1-A-NR4— or a 5- or 6-membered carbocyclic or heterocyclic ring; A is a bond, SO2, C═O, NR9(C═O) or 0(C═O) wherein R9 is hydrogen or C1-4 hydrocarbyl optionally substituted by hydroxy or C1-4 alkoxy; Y is a bond or an alkylene chain of 1 to 3 carbon atoms; R1 is hydrogen; a carbocyclic or heterocyclic group having from 3 to 12 ring members; or an optionally substituted C1-8 hydrocarbyl group wherein 1 or 2 of the carbon atoms of the hydrocarbyl group may optionally be replaced by an atom or group selected from O, S, NH, SO, SO2; R2 is hydrogen; halogen; C1-4 alkoxy; or a C1-4 hydrocarbyl group optionally substituted by halogen, hydroxyl or C1-4 alkoxy; R3 is selected from hydrogen and carbocyclic and heterocyclic groups having from 3 to 12 ring members; and R4 is hydrogen or a C1-4 hydrocarbyl group optionally substituted by halogen, hydroxyl or C1-4 alkoxy; and (b) a compound of formula (I′″) or salts, tautomers, solvates and N-oxides thereof: wherein R1 is 2,6-dichlorophenyl; R2a and R2b are both hydrogen; and R3 is a group: formula (A) where R4 is C1-4 alkyl.

The invention relates to a thermo-electric pile infrared detector, which comprises a substrate with a full-hollow structure, a thermo-electric pile, a first infrared absorption layer, a passivation layer, a reflective layer and a second infrared absorption layer formed by the release technology of a sacrifice layer, wherein the thermo-electric pile, the first infrared absorption layer and the passivation layer are formed on the substrate; and the reflective layer is formed on the passivation layer. By the detector, the infrared absorptivity is improved, and temperature difference of a thermoelectric couple at a cold end and a hot end is increased, so the response rate and sensitivity of the detector are improved.

A high-power LED multi-hole phase-changing heat sink structure comprises a radiator inner cavity. A plurality of radiator fins are arranged on the top face of the radiator inner cavity. A metal multi-hole structure is arranged in the radiator inner cavity in a sintering mode. Holes of the metal multi-hole structure are filled with phase-changing materials. An LED electronic chip is arranged on the bottom face of the radiator inner cavity. The melting point of the phase-changing materials is lower than the normal working temperature of the LED electronic chip. The response speed of phase-changing latent heat storing can be increased, the weight and the cost of an LED radiating structure are lowered, a part of heat emitted by the chip during LED working is dissipated in a natural-convection mode, a large part is stored by latent heat absorbed during a phase-changing material melting process, meanwhile, the temperature of the LED chip is controlled through the melting point of the phase-changing materials, and radiating performance is improved. The high-power LED multi-hole phase-changing heat sink structure has the advantages of being simple in structure, light in weight, small in size, good in adjusting performance, good in radiating effect, long in service life, free from external energy loss and environment pollution and the like.

Bymixer devices and methods for sampling or obtaining data from mixed respiratory gases in a ventilation circuit. Respiratory gasses from a plurality of consecutive breaths become mixed within a mixing chamber of the bymixer and samples or data are obtained from such mixed respiratory gasses. Optionally, the volume of the mixing chamber and / or the resistance to flow into or through the mixing chamber may be selectable or adjustable.

The invention discloses an optimization method and an optimization system of SCR denitrification intelligent ammonia injection based on soft measurement and predictive control. The method comprises the following steps: firstly, establishing an entrance nitrogen oxide concentration model based on operation data; then utilizing the model and currently-collected operation data to obtain a predicted value; secondly, calculating the ammonia injection amount at the current operation condition as a feedforward signal according to an entrance nitrogen oxide concentration predicted value and transmitting the feedforward signal of the ammonia injection amount to an SCR denitrification system; thirdly, measuring a measured value of exit nitrogen oxide concentration of a coal-fired generation unit combustion system, making deviation between the measured value and an entrance nitrogen oxide concentration set value and inputting a difference value into a prediction controller, obtaining a feedback control signal of the ammonia injection amount based on the deviation and transmitting the feedback control signal to the SCR denitrification system by a prediction controller; fourthly, controlling the ammonia injection amount of an SCR denitrification reactor according to the feedforward signal of the ammonia injection amount and the feedback control signal of the ammonia injection amount by theSCR denitrification system. The system disclosed by the invention has the advantages of higher response rate, lower investment, short transformation period and the like.