94 results about "Neuralgia" patented technology

In the herpes zoster neuralgia chronic detection and AI identification model training method and system, information of a detector is collected, and the information of the detector comprises age, gender and herpes zoster definite diagnosis time; collecting detection information of a detector, wherein the detection information comprises a ratio of IL18 to IL18BP; pain information of the detected person is collected; the pain information of the detector comprises pain intensity and attack frequency; the pain information of the detected person is marked, marked information is obtained, and the marked information comprises acute pain, chronic pain and the risk degree of converting the acute pain into the chronic pain; performing AI training according to the detector information, the detection information and the annotation information, and obtaining a herpes zoster neuropathic pain AI feature data set after the AI training; the herpes zoster neuralgia AI feature data set is used for detecting the possibility that the herpes zoster neuralgia of the testee is converted from acute pain to chronic pain in combination with AI software. And diagnosis and treatment basis information from a brand new perspective is provided for the post-herpes zoster neuralgia.

The invention discloses a biomarker related to diabetic neuralgia and application of the biomarker. The biomarker is IGFBPs or CD324. According to the application, a DNP (Diabetic Neuralgia) rat model is constructed, the DIA and DDA combined technology is adopted, DNP model rats are subjected to serum proteome detection, and through analysis, screening and verification, compared with normal group rats, the expression level of IGFBPs or CD324 in serum of the DNP model rats has significant difference; according to the method, IGFBPs or CD324 is taken as a biomarker, a working characteristic curve (ROC) of a subject is drawn at the same time, and IGFBPs or CD324 is evaluated according to area under the curve (AUC) to have excellent diagnostic efficiency when applied to diabetic neuralgia as the biomarker, so that a new biomarker can be provided for auxiliary diagnosis of diabetic neuralgia, and clinical diagnosis of diabetic neuralgia is more convenient and accurate.

The invention discloses a trigeminal neuralgia treatment method, and relates to the technical field of trigeminal neuralgia treatment. The direct effect of the M2 on the proinflammatory and pain induction characteristics of the Schwann cells can play an important role in the multi-aspect analgesic effect of the M2; the microenvironment around nerves can be changed by increasing m < 2 > m macrophages after SHED-CM, so that NP is cured; immunohistochemical analysis shows that the number of p near-end side CD206 + F4 / 80 + macrophages of qualified thiocyanate is remarkably increased through sheet-CM treatment, however, TNF-alpha + S100beta + proinflammatory Schwann cells and TNF-alpha + F4 / 80 + M1 macrophages are remarkably reduced after sheet-CM treatment.

A natural supplement is described herein. The supplement includes a therapeutically effective amount of a composition. The composition includes: at least two materials having analgesic activity, at least two materials having anti-inflammatory activity, at least two materials having antioxidant activity, at least two materials having anti-neuralgic activity, at least two materials having blood circulation promotion activity, at least one material having Dihydrotestosterone (DHT) blocking activity, and at least one material having hair thickening activity or hair growth activity. The natural supplement not only provides pain relief from a variety of symptoms, but also promotes hair growth.

The application discloses a device for judging the decompression effect of intraoperative trigeminal neuralgia, and relates to the technical field of medical monitoring devices, comprising a forceps body, a collection probe is arranged at the tip of the forceps body, a wiring box is arranged on the side of the forceps body away from the collection probe, a distance adjusting mechanism and an auxiliary center positioning mechanism are arranged between the wiring box and the forceps body, the forceps body with adjustable spacing and the distance adjusting mechanism are arranged, the flexible adjustment of the spacing of the collection probe is achieved, the overall signal of the ganglion segment can be detected by increasing the spacing, the smaller nerve area can be focused by reducing the spacing, the signal difference under different spacings is compared, the compression point is accurately positioned, blind decompression is avoided, the auxiliary center positioning mechanism is arranged, the center point of the forceps body and the corresponding position of the collection probe are quickly positioned, the medical staff accurately aims at the trigeminal nerve to be detected, the positioning deviation is avoided, the collection signal is not inaccurate, the trigeminal neuralgia clustering neural network algorithm is combined, a visual distribution view is generated, and the accuracy of decompression effect judgment and the operation efficiency are improved.

The present invention belongs to the technical field of pain relief preparations, and particularly relates to a pain relief preparation, a preparation method thereof and an application. The pain relief preparation is composed of (+)-camphene, a propylene glycol extract of Bupleurum chinense DC. and pharmaceutically acceptable excipients. Among them, the mass ratio of (+)-camphene to the propylene glycol extract of Bupleurum chinense DC. is 1-2.5:1. The propylene glycol extract of Bupleurum chinense DC. is prepared by the following method: Bupleurum chinense DC. is ground into powder, mixed with propylene glycol, extracted by ultrasonic treatment, filtered, the filtrate is collected and dried to obtain the propylene glycol extract of Bupleurum chinense DC. The present invention also provides a preparation method of the pain relief preparation, and proves the application of the pain relief preparation in relieving acute pain and postherpetic neuralgia, expanding the types of pain relief preparations.

The invention discloses an immunogenic composition containing gE nanoparticles as well as a preparation method and application thereof, and relates to the technical field of biomedicine, the immunogenic composition comprises self-assembled gE nanoparticles and an oil-in-water emulsion adjuvant, and a self-assembled gE nanoparticle antigen comprises gE, a connecting peptide SGS and a gI polypeptide sequence containing Th epitopes; the oil-in-water type emulsion adjuvant is prepared from squalene, Tween 80, DL-alpha-tocopherol and / or Span 85. The immunogenic composition provided by the invention can be applied to vaccines for preventing varicella and / or herpes zoster and / or postherpetic neuralgia, so that the aims of improving the immunogenicity of the gE antigen and reducing side effects of the vaccines are fulfilled.

The invention provides a traditional Chinese medicine composition for treating prosopalgia as well as a preparation method and a quality control method thereof, and belongs to the technical field of traditional Chinese medicines. On one hand, the invention provides a traditional Chinese medicine composition for treating prosopalgia; secondly, the invention provides a preparation method of the traditional Chinese medicine composition for treating trigeminal neuralgia. Thirdly, the invention further provides application of the traditional Chinese medicine composition in preparation of drugs for treating prosopalgia. Fourthly, the invention further provides a fingerprint spectrum construction method of the traditional Chinese medicine composition for treating trigeminal neuralgia. In the fifth aspect, the invention also provides application of the fingerprint spectrum in detection and quality control of drugs for treating trigeminal neuralgia.

The invention discloses a transdermal patch containing lidocaine, the transdermal patch comprises a polymer matrix layer, the polymer matrix layer comprises active ingredients lidocaine, an acrylic acid pressure-sensitive adhesive and a penetration enhancer, the weight content of the lidocaine is 21-33%, the weight content of the acrylic acid pressure-sensitive adhesive is 45-75%, the weight content of the penetration enhancer is 1-10%, and the weight content of the penetration enhancer is 1-10%. The weight content of the penetration enhancer is 3%-25%. The transdermal patch disclosed by the invention is simple in prescription and process, good in drug permeability and colloid application performance and high in stability, can be continuously used for a long time without causing skin irritation, and is suitable for treating peripheral nerve related pains, especially patients requiring long-term administration such as post-herpes zoster neuralgia.

The invention relates to preparation of a traditional Chinese medicine nanoemulsion gel spray for treating post-herpes zoster neuralgia. The nanoemulsion gel spray is prepared from the following raw material components: rhizoma corydalis, rhizoma chuanxiong, honeysuckle flowers, radix scutellariae, peach kernels, flos carthami, poloxamer 407, soybean oil, glycerol and pure water. Corydalis tuber, ligusticum wallichii, honeysuckle, radix scutellariae, peach kernel and safflower are adopted as traditional Chinese medicine raw material components, the traditional Chinese medicine raw material components are green, natural, free of hormone and capable of being used for a long time, effective components can effectively relieve and treat neuralgia after herpes zoster, soybean oil, glycerol and pure water are adopted as auxiliary materials, the auxiliary materials and the traditional Chinese medicine components are mixed and subjected to ultrasonic treatment, and the nano-emulsion is obtained. Then the nano-emulsion and poloxamer 407 are fully mixed to prepare nano-emulsion gel, and finally the nano-emulsion gel is canned to obtain the spray.

The present invention relates to a novel use of TGF-β for the prevention and / or treatment of manifestations of the neuralgic component of disorders such as pain and itching.

The present invention relates to the compound 2-hydroxy-octadecene-9-cis-oate for use in the treatment of oncological pathologies including grade IV glioblastoma with native IDH, grade 3 glioma, embryonal tumour, pituitary tumour, meningioma, haemangiopericytoma, haemangioblastoma, mesothelioma, bile duct adenocarcinoma, exocrine pancreatic cancer, neuroendocrine pancreatic cancer, rectal cancer, urachal cancer, adenocarcinoma of the bladder and oesophageal cancer, and for the treatment of neuropathic pain caused by diabetic peripheral neuropathy, spinal cord injury, post-herpetic neuralgia, chemotherapeutic agent, antitumour agent, cancer, fibromyalgia or hepatitis. The present invention also relates to the pharmaceutical composition comprising 2-hydroxy-octadecene-9-cis-oate.

The invention discloses a trigeminal neuralgia percutaneous puncture path planning method and system. The method comprises the following steps: acquiring skull CT (Computed Tomography) image data and MRI (Magnetic Resonance Imaging) image data of a target, and performing three-dimensional reconstruction to obtain an oval foramen bony model and a McLeod cavity three-dimensional model; determining an anatomical entry point, determining a bony channel constraint point based on an oval foramen bony model, and determining an ideal end point of a puncture path based on a McLeod cavity three-dimensional model; taking the anatomical entry point as a path starting point, taking the ideal end point as a path end point target, taking the bony channel constraint point as a path space constraint condition for path passing, and optimizing a target function to obtain an optimal puncture path; based on the McLeod cavity three-dimensional model space volume, determining an individualized balloon injection amount estimation range of a target; and storing the space coordinate and the direction vector of the optimal puncture path and the individualized balloon injection amount estimation range as a standardized digital file. According to the invention, the certainty and safety of the puncture path can be improved.

The invention discloses wearable pain relieving equipment and a remote monitoring system thereof. The wearable pain relieving equipment comprises a multi-mode physiological sensor array, a data fusion processing module, a control module, a transcutaneous electrical stimulation output module, a communication module and the remote monitoring system. The multi-mode sensor array collects myoelectricity, skin conductance, body surface temperature, heart rate, brain oxygen and other pain related physiological parameters, the data fusion module generates a pain estimated value, the control module dynamically adjusts the stimulation intensity based on a PID + differential compensation algorithm, and the transcutaneous electrical stimulation module outputs current to intervene in pain. The communication module uploads data to a remote monitoring system, and medical staff can monitor and remotely adjust parameters in real time through a cloud platform. The system realizes real-time monitoring, intelligent control and remote intervention of pain, has the advantages of personalized treatment, data safety, expandability and the like, and is suitable for scenes of postoperative pain management, chronic neuralgia and the like.

The utility model relates to the technical field of medical instruments, and provides a trigeminal neuralgia temperature control radio frequency thermocoagulation treatment guide plate which comprises a plate body and two identical guide cylinders, guide grooves are formed in the middles of the inner walls of the guide cylinders, clamping grooves which are evenly distributed are formed in the top ends of the inner walls of the guide cylinders, and guide blocks are slidably connected to the middles of the inner walls of the guide cylinders. A storage groove is formed in the top end of the inner wall of the guide block, and a spring is fixedly connected to the inner bottom end of the storage groove. According to the temperature control radio frequency thermal coagulation treatment guide plate, through cooperation of the connecting block, the guide cylinder, the guide groove, the clamping groove, the guide block, the containing groove, the spring, the elastic bean and the fixing block, the effect of adjusting the range of the elastic bandage is achieved, and then the temperature control radio frequency thermal coagulation treatment guide plate can be effectively fixed to the head or the face of a patient; the fixing capability not only ensures the stability of the guide plate in the treatment process, but also can help a doctor to accurately control the treatment position and angle, so that the treatment accuracy and safety are improved.

The invention discloses an automatic puncture painless interventional therapeutic apparatus for prosopalgia, which relates to the technical field of medical instruments and comprises a digital subtraction angiography, a manipulator arranged on the outer side of the digital subtraction angiography and a controller (not drawn in the figure) for controlling the manipulator to move. The mounting disc is fixedly connected to the end face of the mechanical arm, the fixing disc is fixedly connected to the end face of the mounting disc, the adjusting mechanism is fixedly connected to the end face of the mounting disc, the fixing and locking mechanism is connected with the fixing disc, and the adjusting mechanism comprises a driving motor fixedly connected to the end face of the mounting disc and a bearing disc fixedly connected to the output end of the driving motor. According to the automatic puncture painless interventional therapeutic apparatus for prosopalgia, a driving motor is started to drive a bearing disc to rotate until an opening of the bearing disc right faces a needed movable block, then an electric telescopic rod of the movable block is started, the movable block is inserted into the bearing disc, and replacement of a puncture needle is achieved.

The invention relates to amitriptyline gel as well as a preparation method and application thereof, and belongs to the technical field of medicines. The invention provides amitriptyline gel. The amitriptyline gel is prepared from the following components in parts by mass: 2 to 8 parts of amitriptyline hydrochloride, 16 to 24 parts of glycerol, 2 to 8 parts of hydroxypropyl methylcellulose, 16 to 24 parts of 70 to 80 percent ethanol solution, 0.05 to 0.15 part of ethylparaben, 0.2 to 0.8 part of laurocapram and 36 to 64 parts of water. The amitriptyline gel plaster prepared from the amitriptyline gel can effectively relieve postherpetic neuralgia, and compared with traditional oral tablets, the amitriptyline gel plaster can effectively reduce side effects.

A balloon catheter with positioning and protection functions is used for percutaneous microballoon compression surgery to treat trigeminal neuralgia. It includes a balloon assembly (1) and a catheter assembly (2). The balloon assembly (1) includes a first marker point (11), a second marker point (12), a latex balloon (13), and a third marker point (14). The latex balloon (13) consists of two parts. Its distal part has a smaller outer diameter after inflation and serves as the positioning part (131). Its proximal part has a larger outer diameter after inflation and serves as the compression part (132). The second marker point (12) is located at the junction of the positioning part (131) and the compression part (132) of the latex balloon (13) when it is inflated to the normal size. The positioning step on the latex balloon avoids excessive compression of the posterior fossa during the operation. The location of the balloon step is marked by the second marker point. With the help of preoperative 3D modeling, the balloon position is accurately determined, which reduces the difficulty of the operation.

The invention discloses a compound and application of the compound in medicine, and particularly relates to a novel compound and a medicine composition containing the compound. The invention further relates to a preparation method of the compound and application of the compound or the pharmaceutical composition in preparation of drugs for treating GPR84 antagonist mediated diseases and / or symptoms, in particular to application of the compound or the pharmaceutical composition in preparation of drugs for treating non-alcoholic fatty liver diseases, inflammatory bowel diseases, idiopathic pulmonary fibrosis and diabetic neuralgia.

The application discloses a method for constructing a herpes zoster neuralgia animal model by using a recombinant VZV gE protein and application thereof, and comprises the following steps: preparing an immunogen by using an effective dose of a recombinant VZV gE protein, wherein the recombinant VZV gE protein is expressed by E. coli and obtained by purification; and injecting the immunogen into a non-human mammal in vivo, and inducing a persistent pain behavior in the non-human mammal, so that a herpes zoster neuralgia animal model is constructed. The application has the advantages of high biological safety, accurate simulation, stable model phenotype and good repeatability.

The invention discloses a preparation method of a tetrodotoxin (TTX) external preparation and an application of the tetrodotoxin (TTX) external preparation in treatment of postherpetic neuralgia. The method comprises the following steps: preparing external preparations with different TTX contents, establishing a postherpetic neuralgia animal model, and verifying the treatment effect of the external preparations on the postherpetic neuralgia through animal experiments. TTX is an amino perhydroquinazoline type small molecule compound. A novel preparation is developed on the basis that tetrodotoxin is a voltage-gated sodium ion channel inhibitor. Experiments prove that by inhibiting the tetrodotoxin sensitive voltage-gated sodium ion channel Nav1.7, the tetrodotoxin external preparation shows remarkable postherpetic neuralgia resistance activity, and can be researched and developed as a postherpetic neuralgia medicine.

The invention relates to a PROTAC molecule with a function of targeted degradation of a Sigma-1 (sigma 1) receptor and application of the PROTAC molecule in preparation of drugs for preventing and treating pain-related diseases. The compounds are compounds having a general formula (I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Experimental results show that the compound represented by the formula (I) provided by the invention has relatively high affinity to a sigma-1 receptor, has good Sigma-1 degradation biological activity, shows good analgesic activity in an acetic acid writhing experiment, can also obviously improve paclitaxel-induced neuralgia, and has excellent safety.

The invention relates to the technical field of traditional Chinese medicine, in particular to an oral traditional Chinese medicine composition and an external traditional Chinese medicine composition for treating postherpetic neuralgia, a preparation method and a combined medication method. The oral traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 6-12 parts of scutellaria baicalensis, 3-9 parts of rheum officinale, 9-15 parts of rhizoma anemarrhenae, 12-18 parts of lalang grass rhizome, 9-15 parts of asparagus cochinchinensis, 9-15 parts of honeysuckle, 12-18 parts of rhizoma phragmitis, 9-15 parts of burdock, 6-12 parts of cicada slough, 6-12 parts of gastrodia elata, 6-12 parts of moutan bark, 12-18 parts of kudzu vine root, 12-18 parts of dried rehmannia root and 12-18 parts of tortoise shell. The traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 15-25 parts of gypsum, 10-20 parts of gypsum rubrum, 0.1-0.3 part of borneol, 4-8 parts of mint, 3-7 parts of radix sophorae flavescentis, 4-8 parts of cortex dictamni and 1-3 parts of indigo naturalis. The traditional Chinese medicine composition achieves the aims of quickly and thoroughly relieving pain and regulating and improving the whole body.

The invention discloses a twin drug with analgesic effect and application thereof, the twin drug is formed by connecting a drug A and a drug B through a chemical bond, the drug A is a TRPV1 agonist, and the drug B is lipoic acid, pregabalin, gabapentin, melogabalin or clinigabalin. Meanwhile, the invention also comprises a preparation method of the twin drug, and application of the twin drug or pharmaceutically acceptable salts and compositions thereof in preparation of drugs for preventing and treating pains or nervous system diseases. The twin drug can significantly improve the water solubility of the TRPV1 agonist, has a long-acting analgesic effect on different types of pains such as inflammatory pains and neuralgia, and has an analgesic effect superior to that of a composition of the two components and then superior to that of a single component. Meanwhile, twin drugs show a more lasting analgesic effect and have a good application prospect.

The invention discloses a construction method and application of a herpes zoster neuralgia animal model. The construction method comprises the following steps: preparing an effective dose of VZV virus protein into immunogen; the immunogen is injected into the body of a non-human mammal, and a continuous pain behavior is induced in the body of the non-human mammal, so that the herpes zoster neuralgia animal model is constructed. The method has the advantages of being high in biological safety, accurate in simulation, stable in model phenotype and good in repeatability.

The sacral canal cyst transdermal puncture drainage device comprises a hydrops box and a drainage tube, one end of the drainage tube is closed, the closed end is fixedly connected with a fixing head made of a memory alloy material, the fixing head is used for fixing the drainage tube in a cyst, and the other end of the drainage tube is connected with the hydrops box through a connector assembly; the closed end of the drainage tube is provided with a hydrops through hole for enabling cyst hydrops to enter a tube cavity of the drainage tube, the hydrops box is provided with a hydrops cavity communicated with the tube cavity of the drainage tube, and the upper end of the hydrops cavity is sealed by a puncturable rubber pad. The sacral canal cyst can be conservatively treated, the hydrops box is embedded under the subcutaneous fascia layer of the hip of a patient through an operation, the drainage tube is implanted into subcutaneous tissue through the puncture needle, the closed end of the drainage tube is guided into the sacral canal root cyst, and the drainage tube expands when encountering body temperature and is fixed in the cyst. After an operation, percutaneous puncture is carried out to a hydrops cavity, and liquid in the cyst is extracted, so that the internal capacity and pressure of the cyst are reduced, and sacral neuralgia caused by the cyst is relieved.

The present invention relates to multicomponent mixtures, to compositions containing such mixtures, and to the use thereof in the treatment of tinnitus, craniofacial neuralgia, trigeminal neuralgia, Bell's palsy, hearing loss, anosmia, burning mouth syndrome, peripheral neuropathies, carpal tunnel syndrome, lumbosciatica, idiopathic pain (arthralgia, myalgia of unknown etiology). In greater detail, the present invention relates to multicomponent mixtures comprising or, alternatively, consisting of palmitoylethanolamide (PEA) and at least one ingredient selected from the group comprising or, alternatively, consisting of propolis extract (preferably with an artepillin-C titer equal to or greater than 4.0%), grape seed extract, resveratrol or mixtures thereof and, optionally, one or more of hop extract; Ginkgo Biloba extract; B group vitamins (preferably vitamin B6 and / or B12), or mixtures thereof. Furthermore, the present invention relates to compositions comprising said multicomponent mixtures. Furthermore, the present invention relates to said multicomponent mixtures and / or compositions comprising them for use in the treatment, preventive and / or curative, of tinnitus, craniofacial neuralgia, trigeminal neuralgia, Bell's palsy, hearing loss, anosmia, burning mouth syndrome, peripheral neuropathies, carpal tunnel syndrome, lumbosciatica, idiopathic pain (arthralgia, myalgia of unknown etiology).

This invention discloses a method and system for image enhancement processing of traumatic neuropathic pain, relating to the fields of data processing and artificial intelligence. Based on multi-scale Gaussian difference edge extraction and structural tensor enhancement, this invention achieves precise preservation of blurred lesion boundaries; independently extracts structural features and optimal scale edge features to solve the problem of unbalanced feature responses caused by different lesion sizes; based on dual-path orthogonal constraints combined with spatial weight modulation, it achieves complete decoupling of lesion features from normal tissue; and utilizes edge features to generate a spatial attention mask to guide the reconstruction process while maintaining the continuity of nerve bundles and avoiding noise amplification. This achieves precise preservation of lesion details, effective suppression of noise, and structural reconstruction of the continuity of nerve bundles, providing clearer and more reliable imaging evidence for clinical diagnosis.

The invention belongs to the medicine and health industry, and particularly relates to a traditional Chinese medicine for treating nerve arthralgia. The invention relates to a traditional Chinese medicine for treating nerve arthralgia. The traditional Chinese medicine is prepared from the following raw material medicines in parts by weight: 8-16 parts of ligusticum chuanxiong hort; 8-12 parts of radix clematidis; 8-10 parts of sappan wood; 8-12 parts of bombyx batryticatus; 8-12 parts of radix angelicae pubescentis; 10 to 12 parts of gastrodia elata; 4-12 parts of honey-fried semen strychni; 8-12 parts of uncaria rhynchophylla; 8-12 parts of curcuma zedoary; and 8-12 parts of gentiana macrophylla. Neural arthralgia caused by wind-cold-dampness may be caused by one of pathogenic factors such as wind evil, cold evil and damp evil, wind-cold-dampness is mutually influenced and transformed, wind-cold-dampness is mixed and combined to form arthralgia and causes and effects of each other, a toxin mainly caused by the nerve arthralgia is mainly treated, and meanwhile, the nerve arthralgia caused by the wind-cold-dampness can be effectively treated through the cooperation of monarch, minister, assistant and guide medicines, so that the nerve arthralgia caused by the wind-cold-dampness can be effectively treated. And auxiliary treatment is also performed on the other two items to prevent mutual transformation of the three items, so that the purpose of treating or curing is achieved.

The invention discloses a herpes zoster sequela neuralgia local drug delivery device, and relates to the technical field of drug delivery devices, the herpes zoster sequela neuralgia local drug delivery device comprises a mounting plate and a material pumping assembly; two corresponding mounting grooves are formed in the right side of the mounting plate, a PLC and a storage battery are mounted in the two mounting grooves correspondingly, a moving assembly is mounted at the right end of the front side of the mounting plate, an adjusting assembly is mounted on the right side of the mounting plate, and a sensing assembly is mounted on the front side of the adjusting assembly; a storage assembly is mounted at the left end of the front side of the mounting plate, and a material injection assembly is mounted on the right side of the storage assembly. The material pumping assembly comprises a material pumping barrel, a connecting column and a limiting ring, a strip-shaped groove is formed in the front side of the mounting plate, the material pumping barrel is fixed in the strip-shaped groove, the connecting column is slidably connected in the material pumping barrel, liquid medicine can be accurately injected into the deep layer of dermis through the microneedle technology, and intelligent adjustment and automatic control of medicine administration are achieved.