46 results about "Neuralgia" patented technology

A natural supplement is described herein. The supplement includes a therapeutically effective amount of a composition. The composition includes: at least two materials having analgesic activity, at least two materials having anti-inflammatory activity, at least two materials having antioxidant activity, at least two materials having anti-neuralgic activity, at least two materials having blood circulation promotion activity, at least one material having Dihydrotestosterone (DHT) blocking activity, and at least one material having hair thickening activity or hair growth activity. The natural supplement not only provides pain relief from a variety of symptoms, but also promotes hair growth.

The application discloses a device for judging the decompression effect of intraoperative trigeminal neuralgia, and relates to the technical field of medical monitoring devices, comprising a forceps body, a collection probe is arranged at the tip of the forceps body, a wiring box is arranged on the side of the forceps body away from the collection probe, a distance adjusting mechanism and an auxiliary center positioning mechanism are arranged between the wiring box and the forceps body, the forceps body with adjustable spacing and the distance adjusting mechanism are arranged, the flexible adjustment of the spacing of the collection probe is achieved, the overall signal of the ganglion segment can be detected by increasing the spacing, the smaller nerve area can be focused by reducing the spacing, the signal difference under different spacings is compared, the compression point is accurately positioned, blind decompression is avoided, the auxiliary center positioning mechanism is arranged, the center point of the forceps body and the corresponding position of the collection probe are quickly positioned, the medical staff accurately aims at the trigeminal nerve to be detected, the positioning deviation is avoided, the collection signal is not inaccurate, the trigeminal neuralgia clustering neural network algorithm is combined, a visual distribution view is generated, and the accuracy of decompression effect judgment and the operation efficiency are improved.

The invention discloses an immunogenic composition containing gE nanoparticles as well as a preparation method and application thereof, and relates to the technical field of biomedicine, the immunogenic composition comprises self-assembled gE nanoparticles and an oil-in-water emulsion adjuvant, and a self-assembled gE nanoparticle antigen comprises gE, a connecting peptide SGS and a gI polypeptide sequence containing Th epitopes; the oil-in-water type emulsion adjuvant is prepared from squalene, Tween 80, DL-alpha-tocopherol and / or Span 85. The immunogenic composition provided by the invention can be applied to vaccines for preventing varicella and / or herpes zoster and / or postherpetic neuralgia, so that the aims of improving the immunogenicity of the gE antigen and reducing side effects of the vaccines are fulfilled.

The invention discloses a transdermal patch containing lidocaine, the transdermal patch comprises a polymer matrix layer, the polymer matrix layer comprises active ingredients lidocaine, an acrylic acid pressure-sensitive adhesive and a penetration enhancer, the weight content of the lidocaine is 21-33%, the weight content of the acrylic acid pressure-sensitive adhesive is 45-75%, the weight content of the penetration enhancer is 1-10%, and the weight content of the penetration enhancer is 1-10%. The weight content of the penetration enhancer is 3%-25%. The transdermal patch disclosed by the invention is simple in prescription and process, good in drug permeability and colloid application performance and high in stability, can be continuously used for a long time without causing skin irritation, and is suitable for treating peripheral nerve related pains, especially patients requiring long-term administration such as post-herpes zoster neuralgia.

The present invention relates to the compound 2-hydroxy-octadecene-9-cis-oate for use in the treatment of oncological pathologies including grade IV glioblastoma with native IDH, grade 3 glioma, embryonal tumour, pituitary tumour, meningioma, haemangiopericytoma, haemangioblastoma, mesothelioma, bile duct adenocarcinoma, exocrine pancreatic cancer, neuroendocrine pancreatic cancer, rectal cancer, urachal cancer, adenocarcinoma of the bladder and oesophageal cancer, and for the treatment of neuropathic pain caused by diabetic peripheral neuropathy, spinal cord injury, post-herpetic neuralgia, chemotherapeutic agent, antitumour agent, cancer, fibromyalgia or hepatitis. The present invention also relates to the pharmaceutical composition comprising 2-hydroxy-octadecene-9-cis-oate.

The invention discloses a trigeminal neuralgia percutaneous puncture path planning method and system. The method comprises the following steps: acquiring skull CT (Computed Tomography) image data and MRI (Magnetic Resonance Imaging) image data of a target, and performing three-dimensional reconstruction to obtain an oval foramen bony model and a McLeod cavity three-dimensional model; determining an anatomical entry point, determining a bony channel constraint point based on an oval foramen bony model, and determining an ideal end point of a puncture path based on a McLeod cavity three-dimensional model; taking the anatomical entry point as a path starting point, taking the ideal end point as a path end point target, taking the bony channel constraint point as a path space constraint condition for path passing, and optimizing a target function to obtain an optimal puncture path; based on the McLeod cavity three-dimensional model space volume, determining an individualized balloon injection amount estimation range of a target; and storing the space coordinate and the direction vector of the optimal puncture path and the individualized balloon injection amount estimation range as a standardized digital file. According to the invention, the certainty and safety of the puncture path can be improved.

The utility model relates to the technical field of medical instruments, and provides a trigeminal neuralgia temperature control radio frequency thermocoagulation treatment guide plate which comprises a plate body and two identical guide cylinders, guide grooves are formed in the middles of the inner walls of the guide cylinders, clamping grooves which are evenly distributed are formed in the top ends of the inner walls of the guide cylinders, and guide blocks are slidably connected to the middles of the inner walls of the guide cylinders. A storage groove is formed in the top end of the inner wall of the guide block, and a spring is fixedly connected to the inner bottom end of the storage groove. According to the temperature control radio frequency thermal coagulation treatment guide plate, through cooperation of the connecting block, the guide cylinder, the guide groove, the clamping groove, the guide block, the containing groove, the spring, the elastic bean and the fixing block, the effect of adjusting the range of the elastic bandage is achieved, and then the temperature control radio frequency thermal coagulation treatment guide plate can be effectively fixed to the head or the face of a patient; the fixing capability not only ensures the stability of the guide plate in the treatment process, but also can help a doctor to accurately control the treatment position and angle, so that the treatment accuracy and safety are improved.

A balloon catheter with positioning and protection functions is used for percutaneous microballoon compression surgery to treat trigeminal neuralgia. It includes a balloon assembly (1) and a catheter assembly (2). The balloon assembly (1) includes a first marker point (11), a second marker point (12), a latex balloon (13), and a third marker point (14). The latex balloon (13) consists of two parts. Its distal part has a smaller outer diameter after inflation and serves as the positioning part (131). Its proximal part has a larger outer diameter after inflation and serves as the compression part (132). The second marker point (12) is located at the junction of the positioning part (131) and the compression part (132) of the latex balloon (13) when it is inflated to the normal size. The positioning step on the latex balloon avoids excessive compression of the posterior fossa during the operation. The location of the balloon step is marked by the second marker point. With the help of preoperative 3D modeling, the balloon position is accurately determined, which reduces the difficulty of the operation.

The application discloses a method for constructing a herpes zoster neuralgia animal model by using a recombinant VZV gE protein and application thereof, and comprises the following steps: preparing an immunogen by using an effective dose of a recombinant VZV gE protein, wherein the recombinant VZV gE protein is expressed by E. coli and obtained by purification; and injecting the immunogen into a non-human mammal in vivo, and inducing a persistent pain behavior in the non-human mammal, so that a herpes zoster neuralgia animal model is constructed. The application has the advantages of high biological safety, accurate simulation, stable model phenotype and good repeatability.

The invention relates to a PROTAC molecule with a function of targeted degradation of a Sigma-1 (sigma 1) receptor and application of the PROTAC molecule in preparation of drugs for preventing and treating pain-related diseases. The compounds are compounds having a general formula (I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Experimental results show that the compound represented by the formula (I) provided by the invention has relatively high affinity to a sigma-1 receptor, has good Sigma-1 degradation biological activity, shows good analgesic activity in an acetic acid writhing experiment, can also obviously improve paclitaxel-induced neuralgia, and has excellent safety.

The invention relates to the technical field of traditional Chinese medicine, in particular to an oral traditional Chinese medicine composition and an external traditional Chinese medicine composition for treating postherpetic neuralgia, a preparation method and a combined medication method. The oral traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 6-12 parts of scutellaria baicalensis, 3-9 parts of rheum officinale, 9-15 parts of rhizoma anemarrhenae, 12-18 parts of lalang grass rhizome, 9-15 parts of asparagus cochinchinensis, 9-15 parts of honeysuckle, 12-18 parts of rhizoma phragmitis, 9-15 parts of burdock, 6-12 parts of cicada slough, 6-12 parts of gastrodia elata, 6-12 parts of moutan bark, 12-18 parts of kudzu vine root, 12-18 parts of dried rehmannia root and 12-18 parts of tortoise shell. The traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 15-25 parts of gypsum, 10-20 parts of gypsum rubrum, 0.1-0.3 part of borneol, 4-8 parts of mint, 3-7 parts of radix sophorae flavescentis, 4-8 parts of cortex dictamni and 1-3 parts of indigo naturalis. The traditional Chinese medicine composition achieves the aims of quickly and thoroughly relieving pain and regulating and improving the whole body.

The invention discloses a construction method and application of a herpes zoster neuralgia animal model. The construction method comprises the following steps: preparing an effective dose of VZV virus protein into immunogen; the immunogen is injected into the body of a non-human mammal, and a continuous pain behavior is induced in the body of the non-human mammal, so that the herpes zoster neuralgia animal model is constructed. The method has the advantages of being high in biological safety, accurate in simulation, stable in model phenotype and good in repeatability.

This invention discloses a method and system for image enhancement processing of traumatic neuropathic pain, relating to the fields of data processing and artificial intelligence. Based on multi-scale Gaussian difference edge extraction and structural tensor enhancement, this invention achieves precise preservation of blurred lesion boundaries; independently extracts structural features and optimal scale edge features to solve the problem of unbalanced feature responses caused by different lesion sizes; based on dual-path orthogonal constraints combined with spatial weight modulation, it achieves complete decoupling of lesion features from normal tissue; and utilizes edge features to generate a spatial attention mask to guide the reconstruction process while maintaining the continuity of nerve bundles and avoiding noise amplification. This achieves precise preservation of lesion details, effective suppression of noise, and structural reconstruction of the continuity of nerve bundles, providing clearer and more reliable imaging evidence for clinical diagnosis.

The invention belongs to the medicine and health industry, and particularly relates to a traditional Chinese medicine for treating nerve arthralgia. The invention relates to a traditional Chinese medicine for treating nerve arthralgia. The traditional Chinese medicine is prepared from the following raw material medicines in parts by weight: 8-16 parts of ligusticum chuanxiong hort; 8-12 parts of radix clematidis; 8-10 parts of sappan wood; 8-12 parts of bombyx batryticatus; 8-12 parts of radix angelicae pubescentis; 10 to 12 parts of gastrodia elata; 4-12 parts of honey-fried semen strychni; 8-12 parts of uncaria rhynchophylla; 8-12 parts of curcuma zedoary; and 8-12 parts of gentiana macrophylla. Neural arthralgia caused by wind-cold-dampness may be caused by one of pathogenic factors such as wind evil, cold evil and damp evil, wind-cold-dampness is mutually influenced and transformed, wind-cold-dampness is mixed and combined to form arthralgia and causes and effects of each other, a toxin mainly caused by the nerve arthralgia is mainly treated, and meanwhile, the nerve arthralgia caused by the wind-cold-dampness can be effectively treated through the cooperation of monarch, minister, assistant and guide medicines, so that the nerve arthralgia caused by the wind-cold-dampness can be effectively treated. And auxiliary treatment is also performed on the other two items to prevent mutual transformation of the three items, so that the purpose of treating or curing is achieved.

The invention discloses a herpes zoster sequela neuralgia local drug delivery device, and relates to the technical field of drug delivery devices, the herpes zoster sequela neuralgia local drug delivery device comprises a mounting plate and a material pumping assembly; two corresponding mounting grooves are formed in the right side of the mounting plate, a PLC and a storage battery are mounted in the two mounting grooves correspondingly, a moving assembly is mounted at the right end of the front side of the mounting plate, an adjusting assembly is mounted on the right side of the mounting plate, and a sensing assembly is mounted on the front side of the adjusting assembly; a storage assembly is mounted at the left end of the front side of the mounting plate, and a material injection assembly is mounted on the right side of the storage assembly. The material pumping assembly comprises a material pumping barrel, a connecting column and a limiting ring, a strip-shaped groove is formed in the front side of the mounting plate, the material pumping barrel is fixed in the strip-shaped groove, the connecting column is slidably connected in the material pumping barrel, liquid medicine can be accurately injected into the deep layer of dermis through the microneedle technology, and intelligent adjustment and automatic control of medicine administration are achieved.

The application discloses a traditional Chinese medicine compound preparation for external use for relieving post-herpetic neuralgia and trigeminal neuralgia, which comprises effective components and auxiliary materials; the effective components specifically comprise rhizoma corydalis, rhabdophis nigrscens, chuanxiong rhizome, radix paeoniae alba, radix stellae, zanthoxylum bungeanum, menthol, and borneol; and the auxiliary materials comprise carbomer 940, glycerol, choline chloride, triethanolamine, and disodium edetate. The traditional Chinese medicine preparation can effectively relieve post-herpetic neuralgia and trigeminal neuralgia and has an antipruritic effect.

The present invention relates to the use of botulinum toxins for the treatment of peripheral neuropathic pain (PNP) by topical administration of botulinum toxins. The administration includes subcutaneously injecting an effective amount of botulinum toxin into a region of the skin of the patient affected by pain according to a specific administration regimen. The peripheral neuropathic pain may be, for example, post-herpes zoster neuralgia, peripheral nerve injury (e.g., due to surgery or trauma), trigeminal neuralgia, painful polyneuropathy (e.g., diabetic neuropathic pain), and painful nerve root disease.

The present disclosure relates to use of tear fluid neuropeptide Y (NPY) level for diagnosis, prognosis, assessment and therapy stratification of corneal nerve damage or loss, corneal neuropathy, corneal neuropathic pain, corneal neuralgia, ocular disease, or peripheral neuropathy.

This invention provides the application of deoxycholic acid in the treatment of postherpetic neuralgia. This invention is the first to discover that deoxycholic acid is effective in treating postherpetic neuralgia, and that inhibiting the nucleus tractus solitarius-paraventricular nucleus circuit of the thalamus is also effective in treating postherpetic neuralgia. A synergistic therapeutic effect was achieved when deoxycholic acid was combined with an inhibitor of the nucleus tractus solitarius-paraventricular nucleus circuit. This invention provides a new strategy for the treatment of postherpetic neuralgia.

The invention discloses a traumatic neuralgia image enhancement processing method and system, and relates to the technical field of data processing and artificial intelligence. According to the invention, based on multi-scale Gaussian difference edge extraction and structure tensor enhancement, fine retention of fuzzy focus boundaries is realized; structural features and optimal scale edge features are independently extracted, and the problem of feature response imbalance caused by different focus sizes is solved; thorough decoupling of focus features and normal tissues is realized based on dual-path orthogonal constraint in combination with spatial weight modulation; the space attention mask is generated by using the edge features, the reconstruction process is guided to maintain the continuity of the nerve tract, noise amplification is avoided, accurate reservation of focus details, effective suppression of noise and structural reconstruction of the continuity of the nerve tract are realized, and clearer and more credible image basis is provided for clinical diagnosis.

1. The name of the design product: intelligent pain treatment instrument. 2. The use of the design product: medical equipment combining electronic technology and physiotherapy, suitable for soft tissue injury, arthritis, neuralgia, etc. Different shaped electrode plates can be adapted to acupoint pressing or large area treatment. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view 1.

This invention relates to the field of pharmaceutical technology, disclosing the application of a synthetic peptide that targets and inhibits GRP in the preparation of a drug for treating diabetic neuropathy. The synthetic peptide sequence is SWYLILRIENGKLVKEVVHVPD. This sequence targets and blocks the GRP / vimentin signaling axis. Vimentin is specifically expressed by astrocytes and is a characteristic protein of astrocyte activation. Astrocyte activation can cause central sensitization, leading to chronic pain and other chronic diseases. This synthetic peptide sequence is used in the preparation of a drug for treating diabetic neuropathy. This invention provides a GRP-targeting inhibitory peptide that has a good therapeutic effect on chronic pain, laying the foundation for clinical treatment of chronic pain and possessing significant application and promotion value.

The present invention relates to a pharmaceutical composition for preventing or treating trigeminal neuralgia, the pharmaceutical composition comprising: a carbamate compound of chemical formula 1 or a pharmaceutically acceptable salt thereof, a solvate or a hydrate; and a pharmaceutically acceptable carrier. The pharmaceutical composition, according to the present invention, may enable the efficient prevention or treatment of trigeminal neuralgia.

The invention provides a trigeminal neuralgia segmentation and classification system based on a Merkel cavity, and relates to the technical field of disease classification. Comprising a trigeminal nerve magnetic resonance imaging segmentation subsystem which is used for automatically segmenting a medical image which is obtained based on magnetic resonance imaging and contains a trigeminal nerve Merkel cavity so as to obtain a segmentation result of the Merkel cavity, and determining a region of interest for classification and use according to the segmentation result; and the trigeminal neuralgia identification and classification subsystem is used for performing trigeminal neuralgia and normal identification and classification on the tested object based on the quantitative characteristics of the segmentation result, and outputting a classification result and probability information. The problems that in the prior art, in trigeminal neuralgia iconography application, manual segmentation is mainly adopted, and segmentation precision and small sample generalization are insufficient are solved.

The invention relates to the technical field of medical detection, and discloses an electroencephalogram signal-based neuropathic pain detection and analysis system, which comprises an electroencephalogram signal acquisition module, a signal preprocessing module, a feature extraction module, a pain detection and analysis module, a result output module and a system calibration module which are electrically connected in sequence to form a closed-loop detection and analysis system, objective detection of neuropathic pain is achieved, subjective description of a patient does not need to be depended on, misdiagnosis and missed diagnosis caused by subjective factors are effectively avoided through pure objective electroencephalogram signal analysis, and a reliable objective basis is provided for clinical diagnosis and treatment; the electroencephalogram signal acquisition precision is high, electroencephalogram signals of different scalp areas are comprehensively acquired through the 32-channel electrode array, various interference signals are effectively filtered out in combination with an improved self-adaptive filtering algorithm, the signal quality is ensured, and a reliable basis is provided for feature extraction and detection analysis.

The invention relates to the technical field of biological medicines, in particular to application of a CCR1 / 5 inhibitor Met-RANTES in inhibition of pathological pain of trigeminal nerves. According to the invention, CCR1 / 5 is taken as a therapeutic target of chronic pain, and a medicine which is remarkable in analgesic effect, small in side effect and capable of relieving chronic pain and improving pain mood is developed by combining the pharmacological function of an inhibitor Met-RANTES of CCR1 / 5. The Met-RANTES inhibits a central nervous system chemokine receptor CCRR1 / 5 in a targeted manner in a regular nasal administration manner, so that pathological mechanical pain-sensitive response and accompanying negative emotion caused by chronic compression of trigeminal nerves can be remarkably relieved, and pain feeling is relieved. In addition, the analgesic effect of the drug combination of the Met-RANTES and the carbamazepine is more obvious than that of the drug combination of the Met-RANTES and the carbamazepine which are independently used. The nasal delivery mode enables the medicine to directly reach the central nervous system, and reduces side effects of the whole body.

This invention discloses a magnetic nanoprobe and kit for assessing postherpetic neuralgia. The magnetic nanoprobe is a complex formed by thiolized carbonized polymer dots, a chelating agent, superparamagnetic molecules, and 2-phospho-D-glyceric acid. 2-phospho-D-glyceric acid specifically reacts with NSE, dehydrating to generate phosphoenolpyruvate and releasing water molecules. The magnetic nanoprobe is specific for NSE and can be used for assessing postherpetic neuralgia. The kit includes the magnetic nanoprobe and instructions, and can determine the NSE marker content in a single sample, with a detection limit better than 1 pg / mL, thereby achieving effective assessment of postherpetic neuralgia.

The invention provides an acetaminophen ointment and a preparation method thereof. According to the ointment composition disclosed by the invention, the medicine can better play a role in local positioning treatment of arthralgia and neuralgia diseases, and meanwhile, the side effect of liver injury caused by oral medicine can be avoided. The ointment composition is good in spreadability, basically free of granular sensation, resistant to heat and stable, the preparation method is simple, the production cost is low, and the ointment composition is especially suitable for large-scale industrial production.

The invention provides an accurate and reliable postherpetic neuralgia prediction method by combining structural magnetic resonance image data with a machine learning technology. According to the method, the risk that the herpes zoster patient develops into the postherpetic neuralgia can be efficiently identified, and the prediction accuracy is greatly improved. Compared with the prior art, the method has the advantages that by comprehensively analyzing multi-dimensional information such as brain structures, functional connections and clinical features, the robustness and generalization ability of the model are enhanced, and the limitation of dependence on single features is reduced. The method also supports early intervention, can provide personalized treatment suggestions for clinic, and helps doctors to formulate more reasonable treatment schemes, so that the life quality of patients is improved, and the method has important clinical application value.

The invention belongs to the field of natural medicines, and provides application of a valerian preparation in preparation of a medicine for treating herpes zoster and complications thereof. The herpes zoster comprises qi stagnation and blood stasis type herpes zoster and middle-aged and elderly herpes zoster, and the complication refers to postherpetic neuralgia. The valerian preparation disclosed by the invention has a relatively good effect on treating qi-stagnation and blood stasis type herpes zoster, middle-aged and elderly herpes zoster and postherpetic neuralgia of herpes zoster, and can obviously shorten the detumescence, scabbing and healing time of herpes zoster; damage to nervous systems and stimulation to inflammatory cells can be reduced, and neuralgia caused by herpes zoster can be eliminated or improved; the traditional Chinese medicine composition is good in clinical curative effect, high in safety and few in adverse reaction, and a new method is provided for clinical treatment of herpes zoster and postherpetic neuralgia thereof.