12 results about "Tissue staining" patented technology

A system including: a carousel including a plurality of mounting stations dimensioned to receive at least one fluid dispensing cartridge; and a receiving assembly positioned beneath the carousel, the receiving assembly including a plurality of reaction stations, each of the plurality of reaction stations including: a body comprising a length dimension and a width dimension that together define a chamber to accommodate a single slide therein; and a lid comprising a first position to cover the chamber and a second position to expose a portion of the chamber. A method including moving a lid of a reaction station to expose a single microscope slide including a sample and dispensing one or more reagents on the sample.

The application discloses a method for generating protein expression information based on tissue staining images, comprising: inputting a tissue staining image to be analyzed into a trained neural network model, and generating protein expression information of at least one protein channel through inference of the neural network model, wherein the neural network model is trained in the following manner: cross-modal feature alignment training is performed on a tissue feature coding network in a neural network model to be trained, so that tissue structure image features are aligned with protein expression image features, to obtain a trained tissue feature coding network; the trained tissue feature coding network and a decoding network in the neural network model to be trained are taken as the neural network model to be trained, and protein expression supervised training is performed, to obtain the trained neural network model. The application reduces complex experimental steps and equipment requirements, can significantly reduce experimental costs and improve the efficiency of obtaining protein expression information.

A sample processor including a body including an inner surface that defines a chamber including an opening in a side of the body and including a volume to accommodate a least one microscope slide therein; a door comprising a first position to cover the opening of the body and a second position to expose a portion of the chamber through the opening; a slide bed disposed in the chamber; one of an internal humidity generator disposed in the chamber and an external humidity generator coupled to the chamber. A system including at least one sample processor at least one reagent outside the body of the at least one sample processor and a method including subjecting a sample on a microscope slide in a sealed chamber to a pressure greater than ambient and a humidity greater than 60 percent; and processing the sample. 20 25 20 31 55 02 M ay 2 02 5 A B S T R A C T 2 0 2 5 2 0 3 1 5 5 0 2 2 0 2 5 M a y

The present invention provides for water-soluble mono- and dicationic fluorescent dyes with the latter exhibiting stable fluorescence at elevated temperatures. The present invention also provides for methods for the production of the fluorescent dyes and for using these dyes in biological assays such as multiplexing qPCR and tissue staining.

A system including: a carousel including a plurality of mounting stations dimensioned to receive at least one fluid dispensing cartridge; and a receiving assembly positioned beneath the carousel, the receiving assembly including a plurality of reaction stations, each of the plurality of reaction stations including: a body comprising a length dimension and a width dimension that together define a chamber to accommodate a single slide therein; and a lid comprising a first position to cover the chamber and a second position to expose a portion of the chamber. A method including moving a lid of a reaction station to expose a single microscope slide including a sample and dispensing one or more reagents on the sample.

A system comprising: a turntable including a plurality of mounting stations sized to receive at least one fluid dispensing cartridge; and a receiving assembly positioned below the turntable, the receiving assembly including a plurality of reaction stations, each of the plurality of reaction stations including: a body including length and width dimensions of a chamber together defining a cavity for receiving a single slide; and a cover including a first position covering the cavity and a second position exposing a portion of the cavity. A method comprising moving the cover of a reaction station to expose a single microscope slide containing a sample, and dispensing one or more reagents onto the sample.

A system including: a carousel including a plurality of mounting stations dimensioned to receive at least one fluid dispensing cartridge; and a receiving assembly positioned beneath the carousel, the receiving assembly including a plurality of reaction stations, each of the plurality of reaction stations including: a body comprising a length dimension and a width dimension that together define a chamber to accommodate a single slide therein; and a lid comprising a first position to cover the chamber and a second position to expose a portion of the chamber. A method including moving a lid of a reaction station to expose a single microscope slide including a sample and dispensing one or more reagents on the sample. 20 25 23 41 61 17 S ep 2 02 5 2 0 2 5 2 3 4 1 6 1 1 7 S e p 2 0 2 5 A B S T R A C T

A sample processor including a body including an inner surface that defines a chamber including an opening in a side of the body and including a volume to accommodate a least one microscope slide therein; a door comprising a first position to cover the opening of the body and a second position to expose a portion of the chamber through the opening; a slide bed disposed in the chamber; one of an internal humidity generator disposed in the chamber and an external humidity generator coupled to the chamber. A system including at least one sample processor at least one reagent outside the body of the at least one sample processor and a method including subjecting a sample on a microscope slide in a sealed chamber to a pressure greater than ambient and a humidity greater than 60 percent; and processing the sample.

A sample processor includes: a body including an inner surface defining a chamber having an opening in a side of the body and including a volume therein for receiving at least one microscope slide; a door including a first position covering the opening of the body and a second position exposing a portion of the chamber through the opening; a slide bed disposed in the chamber; an internal humidity generator disposed in the chamber and one of an external humidity generator coupled to the chamber. A system includes at least one sample processor, at least one reagent outside the body of the at least one sample processor, and a method comprising: subjecting a sample on a microscope slide in a sealed chamber to pressure greater than ambient and humidity greater than 60%; and processing the sample.

The application provides a disease treatment mechanism analysis method, system and application based on single-cell sequencing, spatial transcriptome and mass spectrometry imaging, and specifically belongs to the technical field of multi-omics analysis.The disease treatment mechanism analysis method comprises the following steps: preparing a tissue section;respectively performing tissue staining, single-cell sequencing, Spatial-seq 2.0 spatial transcriptome sequencing and mass spectrometry imaging on the tissue section; and performing single-cell spatial multi-omics affine registration and data joint analysis.The disease treatment mechanism analysis method fuses the data of multiple omics, has high spatial resolution, can realize cell subtype positioning, can comprehensively analyze the multidimensional mechanism of drug treatment of complex diseases from gene expression to metabolite, and breaks through the spatial and data integration limitations of traditional technologies.

The utility model relates to dyeing kit relevant field, specifically disclose a kind of plant tissue dyeing kit, including sealing cover, reagent box main part, dyeing plate and dyeing agent feeding plate, the top of reagent box main part is equipped with sealing cover, the top of sealing cover is equipped with hand handle, the top end middle part of reagent box main part is equipped with dyeing agent feeding plate, the inside of reagent box main part is equipped with the dyeing plate that can be pulled out, the middle of dyeing plate is equipped with dyeing tank, the inside of dyeing tank is equipped with stirring frame. The utility model's reagent box main part top end middle part is equipped with dyeing agent feeding plate, and multiple dyeing agent feeding plate and marker card are equipped on dyeing agent feeding plate, and feeding plate and marker card are accurately classified to join in dyeing, and it is convenient to make up material, the bottom end middle part of dyeing agent feeding plate is equipped with hopper, and dyeing is conveniently added by hopper Anti-sputtering, it is safer to use.

A sample processor including a body including an inner surface that defines a chamber including an opening in a side of the body and including a volume to accommodate a least one microscope slide therein; a door comprising a first position to cover the opening of the body and a second position to expose a portion of the chamber through the opening; a slide bed disposed in the chamber; one of an internal humidity generator disposed in the chamber and an external humidity generator coupled to the chamber. A system including at least one sample processor at least one reagent outside the body of the at least one sample processor and a method including subjecting a sample on a microscope slide in a sealed chamber to a pressure greater than ambient and a humidity greater than 60 percent; and processing the sample.