2633results about "Nanosensors" patented technology

The invention belongs to the technical field of SERS (Surface Enhanced Raman Scattering) detection, and particularly relates to a preparation method and application of an Ag-coated NiFe2O4 composite SERS substrate. The preparation method comprises the following steps: firstly, preparing Ag nanoparticles which are uniformly distributed and have the same size through a sodium citrate reduction method; secondly, a nanometer flower type NiFe2O4 material is prepared through a hydrothermal method and a calcination method; and finally, the novel SERS substrate Ag-coated NiFe2O4 is prepared through a physical stirring method. The novel SERS substrate made of the Ag nano particles and the nano-flower type NiFe2O4 material is constructed, and compared with a conventional SERS substrate made of independent Ag nano particles, the SERS substrate can detect stronger intrinsic Raman signals of probe molecules. As the SERS substrate needs to be compounded with a nano-flower type NiFe2O4 material during preparation, a charge transfer phenomenon can occur at an interface where the SERS substrate is in contact with probe molecules, so that intrinsic Raman signals of the probe molecules can be enhanced, and the SERS substrate can be better used for detecting and analyzing chemical substances.

The invention relates to the field of electronic detectors, and discloses an ultrafast and efficient electronic detector based on nano polycrystalline boron nitride, which comprises a nano polycrystalline boron nitride scintillator, a light guide and a photomultiplier, and is characterized in that the nano polycrystalline boron nitride scintillator and the photomultiplier are respectively connected with the front end and the rear end of the light guide, a nano polycrystalline boron nitride material of the nano polycrystalline boron nitride scintillator is prepared by taking a sapphire single crystal wafer as a substrate, using NH3 and BCl3 or NH3 and BF3 as raw material gases and adopting a chemical vapor deposition furnace for epitaxial growth. In the invention, the nano polycrystalline boron nitride scintillator has short electron decay time and high scintillation light yield, and can realize ultrafast and efficient electron radiation detection when being applied to an electron detector. The electron detector can be applied to secondary electron and backscattered electron detection in an electron beam detection system, and a new choice is provided for the electron beam detection technology.

The invention provides an endangered animal monitoring method based on a multi-mode floating gate type photoelectric synapse transistor, realizes multi-mode fusion of images (optical signals) and sounds (electric signals) by utilizing the light absorption capability of quantum dots and the high carrier mobility of a two-dimensional channel material, and belongs to the technical field of sensing, storage and calculation integration and endangered animal identification and monitoring. According to the method, a photoelectric synapse device is used as a reservoir, and input time sequence signals are respectively applied to a multi-mode fused photoelectric synapse transistor in the form of light and electric pulse. And along with the co-stimulation of light and electric pulse, the change response of source-drain current is generated, and the fusion processing of the multi-mode signal is realized. By adopting the method, a human multi-sensory fusion signal processing mode is successfully simulated, and accurate recognition under complex and changeable conditions can be realized by utilizing a mode of complementation of visual signals and auditory signals. Under an extreme environment or a high noise condition, edge processing and identification can be carried out on pictures and sounds of endangered animals, and a high-accuracy monitoring result can be obtained without a large amount of data return, so that the energy consumption is reduced and the monitoring efficiency is enhanced.

The invention provides a flexible HP-ZIF-67 (at) Au surface enhanced Raman scattering substrate for multi-phase detection of volatile organic gas and pesticide residues, and a preparation method and application thereof, and belongs to the technical field of volatile organic gas and pesticide residue detection. The preparation method comprises the following steps: preparing a polystyrene microsphere template by taking polyvinylpyrrolidone, styrene and potassium persulfate as raw materials, then adding 2-methylimidazole and cobalt nitrate to obtain HP-ZIF-67 particles, dispersing the HP-ZIF-67 particles on an aluminum foil to obtain an HP-ZIF-67 substrate, and continuing to diffuse and deposit a gold nanoparticle layer to obtain the flexible HP-ZIF-67 (at) Au surface enhanced Raman scattering substrate. The flexible HP-ZIF-67 (at) Au surface enhanced Raman scattering substrate provided by the invention has the advantages of stable process, high sensitivity and multiphase detection, and a novel composite material is provided for volatile organic gas and pesticide residue detection.

A sequence of polymer units in a polymer (3), eg. DNA, is estimated from at least one series of measurements related to the polymer, eg. ion current as a function of translocation through a nanopore (1), wherein the value of each measurement is dependent on a k-mer being a group of k polymer units (4). A probabilistic model, especially a hidden Markov model (HMM), is provided, comprising, for a set of possible k-mers: transition weightings representing the chances of transitions from origin k-mers to destination k-mers; and emission weightings in respect of each k-mer that represent the chances of observing given values of measurements for that k-mer. The series of measurements is analysed using an analytical technique, eg. Viterbi decoding, that refers to the model and estimates at least one estimated sequence of polymer units in the polymer based on the likelihood predicted by the model of the series of measurements being produced by sequences of polymer units. In a further embodiment, different voltages are applied across the nanopore during translocation in order to improve the resolution of polymer units.

The present invention relates to novel protein pores and their uses in analyte detection and characterisation. The invention particularly relates to an isolated pore complex formed by a CsgG-like pore and a modified CsgF peptide, or a homologue or mutant thereof, thereby incorporating an additional channel constriction or reader head in the nanopore. The invention further relates to a transmembrane pore complex and methods for production of the pore complex and for use in molecular sensing and nucleic acid sequencing applications.

A sequence of polymer units in a polymer (3), eg. DNA, is estimated from at least one series of measurements related to the polymer, eg. ion current as a function of translocation through a nanopore (1), wherein the value of each measurement is dependent on a k-mer being a group of k polymer units (4). A probabilistic model, especially a hidden Markov model (HMM), is provided, comprising, for a set of possible k-mers: transition weightings representing the chances of transitions from origin k-mers to destination k-mers; and emission weightings in respect of each k-mer that represent the chances of observing given values of measurements for that k-mer. The series of measurements is analysed using an analytical technique, eg. Viterbi decoding, that refers to the model and estimates at least one estimated sequence of polymer units in the polymer based on the likelihood predicted by the model of the series of measurements being produced by sequences of polymer units. In a further embodiment, different voltages are applied across the nanopore during translocation in order to improve the resolution of polymer units.

The invention discloses a potassium ion sensor based on AuNPs / MXene / SPCE and a preparation method thereof, and belongs to the technical field of electronic components. Comprising a screen-printed carbon electrode SPCE, an MXene layer modified on the surface of a working electrode of the screen-printed carbon electrode, a gold nanoparticle AuNPs layer formed on the surface of the MXene layer through an electrochemical deposition method, a potassium ion selective membrane covering the gold nanoparticle AuNPs layer, and a GO-PVA hydrogel layer coating the surface of the potassium ion selective membrane. According to the prepared sensor, only potassium ions in sweat can pass through the selective membrane, the selectivity of the sensor is improved, meanwhile, due to the application of the AuNPs / MXene composite material, the surface area-volume ratio of a silk-screen printing carbon electrode is greatly improved, more potassium ions participate in ion-electron conversion, the sensitivity of the sensor is improved, and the application range of the sensor is widened. And the detection range is expanded.

The invention discloses an amorphous tungsten superconducting nanowire single-photon detector, which comprises a photosensitive component, and is characterized in that the photosensitive component is an amorphous tungsten superconducting nanowire; the amorphous tungsten superconducting nanowire is prepared by the following steps: (1) growing an amorphous tungsten film on a substrate; and (2) etching the amorphous tungsten film into a roundabout nanowire structure by using electron beam exposure and reactive ion etching methods to obtain the amorphous tungsten superconducting nanowire. According to the invention, the tungsten nanowire with good stability is used as the main body material of the SNSPD, so that the robustness of the SNSPD preparation process is improved, and the service life of the SNSPD device in practical application is prolonged.

The invention discloses a multi-metal borate nano-particle as well as a preparation method and application thereof. The preparation method comprises the following steps: in the presence of small molecules with alkyl chains, performing high-temperature thermal decomposition on an organic metal compound or a metal salt compound precursor and organic borate in a solvent, and then centrifuging, modifying, performing ultrafiltration, dialyzing and purifying to obtain the multi-metal borate nanoparticles. The preparation method disclosed by the invention has the characteristics of mildness, high efficiency and strong controllability. The multi-metal borate nanoparticles prepared by the preparation method disclosed by the invention have the advantages of monodisperse size, relatively high magnetic property and good biocompatibility. Therefore, the prepared multi-metal borate nanoparticles not only have multi-modal imaging functions such as magnetic resonance imaging, near-infrared two-region imaging, nuclear medicine imaging and magnetic particle imaging, but also can be used for various treatment means such as magnetocaloric therapy and boron neutron capture therapy; potential advantages are realized in biomedical applications such as magnetic targeting tumor treatment and imaging contrast agents, and high practical values are realized.

This invention provides nanostructures comprising a base. and nano-protrusions attached to the base. The invention further provides arrays of such nanostructures on substrates. Also provided by this invention are analysis and catalysis. separation and purification systems and methods. comprising or making use of the novel nanostructures. Particles and films comprising nano-protrusions are included in this invention as well.

The invention relates to the technical field of nano-probe detection, and particularly discloses a nano-probe test system for feeding back contact force in real time, comprising the following modules: a probe execution module comprising a nano-probe and a piezoelectric ceramic driver, the nano-probe realizing three-dimensional micro-displacement and establishing controllable contact with a wafer; the multi-dimensional signal sensing module is used for synchronously acquiring a contact resistance signal and a nanoprobe deformation signal; the data processing and control module is used for realizing signal analysis, force value calculation and driving control of a contact resistance signal and a nanoprobe deformation signal; the man-machine interaction module comprises a touch display screen and a real-time data recorder and is used for realizing visualization of force signals; the data processing and control module carries out cooperative analysis on the contact resistance signal and the nanoprobe deformation signal obtained by the multi-dimensional signal sensing module to obtain the real-time contact force of the nanoprobe and the wafer. The system solves the problem that a traditional nanoprobe detection system cannot feed back the contact force in real time.

The invention discloses a molecular probe for in-vivo copper ion detection and a preparation method and application thereof, the chemical structural formula of the molecular probe is as follows: # imgabs0 #, the molecular probe provided by the invention can specifically respond to copper ions in a tumor subacid environment so as to cause change of an absorption spectrum, and a photoacoustic signal is started so as to detect the copper ions in the tumor subacid environment. Normal tissues and tumor tissues can be accurately distinguished, and accurate detection of the copper ions in the living tumor is realized.

The invention discloses nanoparticles for a contrast agent as well as a preparation method and application of the nanoparticles, and relates to the technical field of nano composite materials. According to the nanoparticle for the contrast agent, a shell layer comprises polydopamine and albumin which are connected through a covalent bond, a core structure comprises a complex formed by metal ions and polyphenol, and the metal ions in the core structure and the polydopamine in the shell layer also have a coordination effect. Due to the fact that all the components are tightly connected, the rotation time of the nano-particles is prolonged, the T1 relaxation rate of the nano-particles is greatly increased, meanwhile, due to introduction of polydopamine, release of metal ions in a human body is avoided, the biological safety of the nano-particles is improved, albumin in the nano-particles can further improve the biocompatibility of the particles, and the nano-particles can be used for preparing the nano-particles. Therefore, the nanoparticles provided by the invention also have wide application prospects in the fields of fluorescence imaging and targeted drug delivery.

The invention discloses an ultrafast motion sensing floating gate transistor based on Van der Waals heterojunction and application thereof. The floating gate transistor comprises a back gate substrate, a Van der Waals heterojunction channel layer, a source electrode and a drain electrode, the source electrode and the drain electrode are arranged on the two sides of the channel layer, the back gate substrate is heavily doped silicon, the surface of the heavily doped silicon is covered with hafnium oxide / aluminum oxide / hafnium oxide (HfO2 / Al2O3 / HfO2) used for nonvolatile light storage, and the Van der Waals heterojunction channel layer is composed of bismuth oxygen selenium-palladium selenide nanosheets used for sensing. The floating gate transistor disclosed by the invention has the capability of quickly responding to an ultraviolet-near infrared wide spectrum and non-volatile storage of light at the same time, and the sensitive spectral response range and responsivity of the photoelectric detector can be effectively improved, so that the integration of dynamic target optical signals in devices in a space domain and a time domain is realized.

Provided are systems, methods, and apparatuses for non-scattering nanostructures of silicon pixel image sensors. In one or more examples, the systems, devices, and methods include forming a metal layer on a substrate layer of the pixel, the metal layer to reflect electromagnetic radiation incident on the pixel; forming a photodetector on a silicon layer of the pixel, the photodetector to generate photoelectrons based on the electromagnetic radiation; and forming a passivation layer over the silicon layer, the passivation layer including a thin film dielectric. In one or more examples, the systems, devices, and methods include forming a nanostructure on the passivation layer, the nanostructure to allow the electromagnetic radiation to pass through the nanostructure and steer the electromagnetic radiation linearly towards the photodetector, and forming a microlens on the nanostructure, the microlens including at least one of a flat coat layer or a curved lensing layer.

The invention provides a carbon monoxide gas-sensitive material as well as a preparation method and application thereof, and belongs to the technical field of gas sensing. The structural formula of the carbon monoxide gas sensitive material is X2Wn-1O3n, X is cadmium or chromium, and n is 2, 3 or 4. The carbon monoxide gas-sensitive material has high sensitivity and selectivity, has good gas-sensitive performance on low-concentration carbon monoxide, reduces the power consumption of a carbon monoxide sensor, and can monitor carbon monoxide leakage for a long time.

The invention provides a resistance-type flexible multifunctional sensor and a preparation method and application thereof. The sensor comprises a flexible fabric, a sensing layer attached to the surface of the flexible fabric and an electrode attached to the surface of the sensing layer. The sensing layer is of an intercalation structure formed by stacking and distributing graphene (GR), carbon nanoparticles (CNPs) and silicone rubber (SR). According to the resistive flexible multifunctional sensor and the preparation method and application thereof, the sensing layer of an intercalation structure formed by stacking and distributing the graphene, the carbon nanoparticles and the silicone rubber is adopted, measurement of pressure, strain and temperature can be achieved at the same time, and therefore the high-performance flexible multifunctional sensor is obtained; and a multi-mode sensing mode is expected to be provided for precise monitoring and somatosensory application.

This application provides methods and compositions related to real time monitoring targeted therapeutics by measuring time-dependent dynamics in distinct subpopulations of secreted vesicles. The technology utilizes bio-orthogonal probe amplification and spatial patterning of molecular reactions within plasmonic resonators to measure EV drug dynamics directly in patient blood samples. Small-molecule click probes are used in the assays for competitive, in situ target labeling in whole vesicles; the labeling of target by the probes can be enzymatically amplified to detect drug occupancy in EVs.

The present disclosure refers to a method for building a SERS substrate from metal nanoparticles for determining the content of phosphonate-based scale inhibitors present at low concentrations in water using surface-enhanced Raman spectroscopy (SERS). The substrates also are used in detergent and dispersant products, in corrosion inhibitors and in water treatment systems in general, such as cooling water and boiler water, in addition to being applied in other fields such as the textile, concrete and paper industries.

The invention discloses a preparation method and application of a magnetic enrichment composite SERS (Surface Enhanced Raman Scattering) detection chip, gold nanoparticles are electrostatically adsorbed on the surface of a magnetic ferroferric oxide nanoring, the prepared material is subjected to cyclodextrin modification, nanogaps among the gold nanoparticles form hot spots, a local electromagnetic field enhancement effect is generated, and the magnetic enrichment composite SERS detection chip is obtained. The cyclodextrin molecules adsorb PAHs in the environment through a hydrophobic effect and are fixed in an electromagnetic field enhancement area, amplification of Raman signals is achieved, the magnetic material serves as a carrier, aggregation of gold nanoparticles can be effectively prevented, SERS signals can be further enhanced through a magnetic enrichment effect, and therefore, the method has the advantages that the method is simple, and the application prospect is wide. The high-sensitivity and high-selectivity detection of PAHs in the tail gas of the engineering machinery vehicle is realized by constructing the magnetic composite SERS nano sensing chip.

The invention discloses a preparation method of a sandwich structure immunosensor based on surface enhanced Raman scattering and application of the sandwich structure immunosensor to detection of an anti-phospholipase A2 receptor antibody, and is characterized by comprising the following steps: sputtering silver ions on a cotton swab / ZIF-67 prepared by an in-situ growth method by adopting an ion sputtering method to obtain a cotton swab / ZIF-67 / Ag NPs composite material; the preparation method comprises the following steps: preparing an antigen solution, then adding the antigen solution into the antigen solution to obtain an immune substrate, adding a methylene blue aqueous solution into a silver nanoparticle solution for reaction, then connecting an anti-human PLA2R IgG antibody to obtain an immune probe, and finally dropwise adding a phosphate buffer solution containing an antibody to be detected onto the immune substrate, and dropwise adding the immune probe solution to the immune substrate adsorbed with the antibody to be detected to obtain the sandwich structure immunosensor based on surface enhanced Raman scattering. The method has the advantages of high sensitivity, good selectivity and strong stability.

This disclosure provides nanoparticle compositions, and use thereof for isolating and measuring proteins, protein degrader action, and cells. The disclosed nanoparticles can be identified by barcodes that reveal the identity of and post translational modifications to the bound protein using image processing techniques described herein.

The invention discloses a preparation method of a large-area and distance-adjustable gold nanoparticle single-layer superlattice film and a product and application thereof, and belongs to the technical field of nanomaterials, the method comprises the following steps: modifying the surfaces of gold nanoparticles by using sulfydryl polystyrene and 1, 8-octyldithiol to obtain double-ligand co-modified gold nanoparticles; an interface assembly strategy is adopted to enable the double-ligand co-modified gold nanoparticles to form a film at the interface of toluene and diethylene glycol, and after toluene volatilizes, the large-area gold nano single-layer superlattice film with the adjustable distance is obtained. According to the method disclosed by the invention, by accurately regulating and controlling double-ligand modification on the surfaces of the gold nanoparticles and optimizing interaction among the particles in the assembly process, accurate regulation and control of the particle spacing of the gold nanoparticle single-layer superlattice film from 1nm to 8nm are realized. The electromagnetic field intensity can be obviously enhanced by accurately regulating and controlling the particle gaps to the sub-nanometer scale, so that the material becomes an ideal SERS substrate, and possibility is provided for developing a metamaterial with a high optical index.

The invention discloses a preparation method and application of a glucose sensor based on an acupuncture needle, the sensor is prepared based on a specific structural design and a molecular recognition mechanism by taking the acupuncture needle as a substrate, and high-specificity and high-sensitivity detection of glucose concentration is realized through drain current change. According to the present invention, the biosensor has the ultra-wide dynamic detection range (0-40 mmol.L <-1 >), covers the clinical range from hypoglycemia to severe hyperglycemia, has the low detection limit of 54 mol.L <-1 >, has excellent grid regulation and control ability, shows the significant on-off ratio and the rapid response characteristic during the detection process, and meets the requirements of the biosensor on sensitivity and real-time performance; and the device has quick response capability to grid voltage change, so that the device has good stability and repeatability under repeated operation, and a direction and a basis can be provided for the development of a blood glucose monitoring technology with continuous, real-time and accurate characteristics.

The invention discloses a micro electro mechanical system semiconductor hydrogen sensor and a preparation method thereof. The sensor comprises SnO2, Au and ZnO layers, a micro heating plate substrate and a ceramic substrate which are arranged from top to bottom, the method comprises the following steps: mounting a target material on a target position; stabilizing the micro heating plate substrate on a heating table; vacuumizing the sputtering chamber to enable the vacuum degree of the sputtering chamber to be below 5 * 10 <-3 > Pa; argon is introduced into the cavity until the pressure in the cavity reaches about 1 Pa; a ZnO film with the thickness of 50-200 nm is formed on the surface of the micro heating plate substrate; an Au film with the thickness of 2-10 nm is formed on the surface of the ZnO film, and a ZnO-Au composite material is obtained; and forming a SnO2 thin film with the thickness of 4-10nm on the surface of the Au thin film to obtain the ZnO-Au-SnO2 sandwich sensitive composite film. The sensor is high in response speed, short in recovery time and high in detection precision, and the hydrogen sensor with the high response value can be prepared through the method.

The invention discloses a preparation method of a piezoelectric self-sterilization cotton fabric-based pressure sensor. The preparation method specifically comprises the following steps: step 1, preparing a modified boron nitride nanosheet; step 2, preparing a modified boron nitride nanosheet / Ag-MOF545 composite material; step 3, preparing a modified boron nitride nanosheet / Ag-MOF545 cotton fabric based piezoelectric material; and 4, preparing the self-sterilization cotton fabric based piezoelectric pressure sensor. According to the piezoelectric self-sterilization cotton fabric-based pressure sensor, on the basis of a piezoelectric polarization effect generated by a piezoelectric material, a stimulation signal of external strain is converted into a piezoelectric current signal to be output, and molecular electrolysis is generated on the surfaces of bacterial cells by utilizing the current signal; meanwhile, the electroporation effect generated by the current can destroy the integrity of a bacterial membrane and induce metabolism disorder of bacteria, and as a physical method, due to the fact that no additional antibacterial material needs to be loaded and the broad-spectrum antibacterial effect is achieved, the bacteria can be thoroughly killed while the drug resistance of the bacteria is effectively avoided.

The invention discloses a preparation method of a protein halo-coated silicon-coated gold nanorod and a PCR amplification method and kit based on the protein halo-coated silicon-coated gold nanorod, and belongs to the technical field of PCR detection. The photo-thermal nano material is composed of an AuNR coated SiO2 core-shell structure and an external protein halo layer, the protein halo layer avoids inhibition of AuNR on a PCR reaction system, meanwhile, adsorption of AuNR on biological small molecules is effectively reduced, non-specific amplification is reduced, and normal amplification of PCR reaction is guaranteed; and the protein halo layer is used as a thermal insulation layer to optimize heat exchange and maintain the temperature uniformity of the reaction liquid. When the kit is applied to a photo-thermal PCR detection reagent, DNA of a pathogen to be detected can be efficiently and stably amplified and detected within 10 minutes, the kit has huge application potential in the fields of early screening of infectious diseases, food safety detection and the like, collaborative optimization of photo-thermal conversion efficiency, biocompatibility, detection sensitivity and operation convenience is achieved, and the kit has a wide application prospect. And an efficient solution is provided for prevention and control of infectious diseases, food safety monitoring and biomedical research.

The invention relates to a metallized microbubble and a preparation method thereof, a construction method of a multifunctional composite probe, and a rapid bacterium capturing and sterilizing method, and belongs to the technical field of functional material preparation. The method aims at solving the technical problems that in the prior art, a metal coating on the surface of the hollow glass microbubble is not uniform, combination is not firm, and stability is poor. According to the technical scheme, the method is characterized by comprising the following steps: mixing surface-activated hollow glass microbubbles with a polyethyleneimine solution for reaction, and washing and drying to obtain polyethyleneimine-coated hollow glass microbubbles; then reacting with a single-stranded DNA buffer solution to obtain an intermediate product loaded with DNA; then introducing a silver nitrate solution to load silver ions on the surface of the compound; and finally, reducing through a sodium borohydride solution to prepare the metallized microbubbles. The metalized microbubbles prepared by the method can be used for constructing a multifunctional composite probe to realize efficient capture and synergistic antibiosis of targets such as bacteria.