1100results about "Nanosensors" patented technology

The invention relates to the technical field of nano-probe detection, and particularly discloses a nano-probe test system for feeding back contact force in real time, comprising the following modules: a probe execution module comprising a nano-probe and a piezoelectric ceramic driver, the nano-probe realizing three-dimensional micro-displacement and establishing controllable contact with a wafer; the multi-dimensional signal sensing module is used for synchronously acquiring a contact resistance signal and a nanoprobe deformation signal; the data processing and control module is used for realizing signal analysis, force value calculation and driving control of a contact resistance signal and a nanoprobe deformation signal; the man-machine interaction module comprises a touch display screen and a real-time data recorder and is used for realizing visualization of force signals; the data processing and control module carries out cooperative analysis on the contact resistance signal and the nanoprobe deformation signal obtained by the multi-dimensional signal sensing module to obtain the real-time contact force of the nanoprobe and the wafer. The system solves the problem that a traditional nanoprobe detection system cannot feed back the contact force in real time.

This disclosure provides nanoparticle compositions, and use thereof for isolating and measuring proteins, protein degrader action, and cells. The disclosed nanoparticles can be identified by barcodes that reveal the identity of and post translational modifications to the bound protein using image processing techniques described herein.

The invention relates to a metallized microbubble and a preparation method thereof, a construction method of a multifunctional composite probe, and a rapid bacterium capturing and sterilizing method, and belongs to the technical field of functional material preparation. The method aims at solving the technical problems that in the prior art, a metal coating on the surface of the hollow glass microbubble is not uniform, combination is not firm, and stability is poor. According to the technical scheme, the method is characterized by comprising the following steps: mixing surface-activated hollow glass microbubbles with a polyethyleneimine solution for reaction, and washing and drying to obtain polyethyleneimine-coated hollow glass microbubbles; then reacting with a single-stranded DNA buffer solution to obtain an intermediate product loaded with DNA; then introducing a silver nitrate solution to load silver ions on the surface of the compound; and finally, reducing through a sodium borohydride solution to prepare the metallized microbubbles. The metalized microbubbles prepared by the method can be used for constructing a multifunctional composite probe to realize efficient capture and synergistic antibiosis of targets such as bacteria.

The invention discloses an SERS (Surface Enhanced Raman Scattering) detection method for paclitaxel drug concentration in blood of a breast cancer patient, and belongs to the technical field of detection. The method comprises the following steps: performing acetonitrile two-step precipitation centrifugal treatment on a blood sample to obtain a detection sample; the method comprises the following steps: constructing a high-sensitivity SERS substrate (the volume ratio of gold nanoparticles to ethanol is 1: (90-100), and a film is formed on a water-cyclohexane interface) through self-assembly of gold nanoparticles on a liquid-liquid interface; the method comprises the following steps: dropwise adding a sample into a substrate, and detecting characteristic peaks of 1024cm <-1 > and 1053cm <-1 > by using a portable Raman spectrometer (785nm, 30mW, 0.5 s); and calculating the paclitaxel concentration in combination with a pre-established quantitative curve. The method is easy and convenient to operate and suitable for clinical bedside rapid monitoring.

The invention provides a graphene-based hydrogen sulfide gas sensor and a preparation method thereof, and relates to the technical field of gas sensors. The preparation method of the graphene-based hydrogen sulfide gas sensor comprises the following steps: soaking the wood substrate in a mixed metal salt solution containing a water-soluble silver salt and a water-soluble transition metal salt; irradiating the soaked wood substrate by using a laser beam at room temperature under the condition of no shielding gas, so that lignin and cellulose in the wood substrate are cracked and reconstructed to form graphene; meanwhile, the mixed metal salt immersed in the wood substrate is decomposed to form bimetallic oxide nanoparticles including silver oxide nanoparticles and transition metal oxide nanoparticles, and the bimetallic oxide nanoparticles are dispersed on the surface of each layer of graphene to obtain a sensitive layer; and coating conductive materials on the wooden substrate and on the two sides of the sensitive layer to form a connecting electrode in contact with the sensitive layer, thereby obtaining the graphene-based hydrogen sulfide gas sensor.

The invention discloses a bismuth telluride nanopore maskless direct writing preparation method based on electron beam irradiation, and belongs to the technical field of nanometer manufacturing. The method comprises the following steps: firstly, constructing an initial nanopore in a two-dimensional bismuth telluride material by utilizing a converged electron beam; and then the aperture size of the nanopore is accurately regulated and controlled by adjusting the beam density of the electron beam. The method effectively solves the key technical bottlenecks of interface chemical residue pollution caused by a traditional photoresist mask process, intrinsic defect formation caused by high-energy particle bombardment and the like, and breaks through the limitation of an existing etching technology in the aspect of sub-nanoscale structure precision control; precise control of the aperture of the nanopore can be achieved by adjusting the irradiation intensity of the electron beam, and the method has the advantages of being easy and convenient to operate, low in cost, environmentally friendly and the like and can be widely applied to the fields of nanometer electronic devices, sensors and the like.

The invention discloses a potentiometric OECT biosensor as well as a preparation method and application thereof, and belongs to the technical field of organic electrochemical sensing. The potentiometric OECT biosensor comprises a device module and a sensing module, the device module comprises a substrate, and a source electrode, a grid electrode and a first floating gate are arranged on the substrate; a semiconductor channel is arranged on the source electrode, and a drain electrode is arranged on the semiconductor channel; a grid control grid is arranged on the grid; a hydrogel electrolyte layer is arranged at the tops of the substrate, the drain electrode, the grid-control grid electrode and the first floating gate; the sensing module adopts an electrode plate; the electrode plate comprises a gold electrode, an Ag / AgCl electrode and a carbon electrode; the gold electrode serves as a sensing grid electrode, an SAM connecting layer, targeted protein molecules and a shielding layer are arranged on the gold electrode, and when the biosensor works, an electrolyte layer is arranged at the top of the sensing module, and the Ag / AgCl electrode serves as a second floating grid; the first floating gate and the second floating gate are connected through a wire. The potentiometric OECT biosensor is high in detection sensitivity and high in response speed, and can meet clinical requirements on rapid and accurate detection.

The invention discloses a flexible gas flow velocity sensor based on ionic conductive gel, and a preparation method and application thereof. The flexible gas flow velocity sensor specifically comprises a semiconductor active layer and a pore-forming agent which are blended, performing spin coating and etching on the interdigital electrode substrate to prepare a semiconductor film with a porous structure; blending an ionic gel precursor solution; and spin-coating or drop-casting the precursor solution, and preparing the gel film with the ionic conduction characteristic through photo-crosslinking. The sensor provided by the invention can realize sensing response to different inert gases and different gas flow rates under low power consumption, and realizes detection application to human respiration through the Bluetooth test module. Air flow is introduced to regulate and control ion mobility, and the sensing performance of the device is improved by means of the porous organic semiconductor film. The flexible sensor can be attached to other objects or the surface of the inner wall of an airflow pipeline, the device is simple in structure and easy to miniaturize, and a millimeter-level micro sensor can be achieved. And the method is suitable for batch preparation of low-power-consumption miniaturized devices.

The invention discloses a room-temperature MEMS carbon monoxide sensor based on an Nb-TiO2 / WO3 heterojunction powder material and a preparation method of the room-temperature MEMS carbon monoxide sensor, and relates to the technical field of carbon monoxide gas detection. The preparation method comprises the following steps: S1, preparing an Nb-TiO2 / WO3 heterojunction powder material by a two-step hydrothermal method; s2, 0.5 g of the Nb-TiO2 / WO3 heterojunction powder material, the aluminum oxide dispersion liquid and glycerol are mixed and subjected to ball milling, and slurry needed by the MEMS carbon monoxide sensor is obtained; s3, dispensing the slurry onto an MEMS gas sensor substrate with an electrode; according to the room-temperature MEMS carbon monoxide sensor provided by the invention, the sensitivity and selectivity of TiO2 to carbon monoxide can be improved through Nb doping and WO3 modification, the combination of the Nb-doped and WO3-modified semiconductor gas-sensitive material and the MEMS device can utilize the characteristics of miniaturization, easy integration, low power consumption, good stability and the like of the MEMS device, and the gas-sensitive gas-sensitive material can be used as a gas-sensitive gas-sensitive material for the room-temperature MEMS carbon monoxide sensor. The response and working consistency of the TiO2 gas-sensitive material to CO at room temperature is greatly improved, and the method has important practical application value for further promoting the development of semiconductor gas-sensitive devices.

The invention discloses a capacitive flexible sensing array based on an FPC technology and a preparation method thereof, PVDF-TrFE and ionic salt [BMIM / Br] in a specific mass ratio are prepared into an ionic thin film dielectric layer under the action of a cross-linking agent, and a specific rectangular pyramid microstructure is given to the ionic thin film dielectric layer through a microneedle structure mold; and an upper electrode layer and a lower electrode layer for channel multiplexing are prepared in combination with an FPC technology, and finally the sensing array is packaged through vacuum hot pressing bonding. The core innovation of the invention lies in that through the synergistic effect of the ion double electric layer effect, the microstructure stress concentration and the FPC electrode multiplexing design, ultrahigh sensitivity (0-20kPa interval sensitivity gt, 30kPa) and low crosstalk (array crosstalk rate lt, 5%) are realized at the same time. The local deformation characteristic of the microneedle structure effectively restrains edge electric field diffusion, the crosstalk problem of a high-density array is solved from the physical structure, and a key technology is provided for application of flexible electronics in the field of precise tactile perception.

The invention discloses construction and application of a confinement enhanced photoelectrochemistry-electrochemiluminescence dual-mode biosensor, and relates to the technical field of biosensing and analytical chemistry. The preparation method of the biosensor comprises the following steps: taking a CdS (at) SiO2 (at) NaYF4: Yb / Tm nano composite material as a substrate to obtain a confinement enhanced photoelectrochemistry (PEC) and electrochemiluminescence (ECL) sensing interface; in combination with a DNA wheel nanostructure triggered by target acetamiprid, signal amplification is realized; and synchronous dual-mode quenching detection of PEC and ECL signals is realized by virtue of peroxidase-like catalytic precipitation and wide-spectrum absorption characteristics of the PtPd-CoSnO3 nanocube. The biosensor prepared by the invention has the advantages of high sensitivity, strong reliability, good selectivity and the like, can be applied to accurate detection of acetamiprid in samples such as agricultural products and the like, and has important application value in the aspects of environmental monitoring and food safety control.

An apparatus for transmitting heat from a component side to a radiator side on a spacecraft includes a component side that contains a heater, an electrical component, an optional first conduction link, and a first portion of a switchable thermal link and a radiator side that includes a radiator, an optional second conduction link and a second portion of a switchable thermal link. The first portion of the switchable thermal link and the second portion of the switchable link are in operative thermal communication with the component side and the radiator side respectively. The first portion of the switchable thermal link and the second portion of the switchable thermal link are reversibly attachable and detachable. The switchable thermal link is operative to receive and radiate thermal energy from the component side to the radiator side.

A method for producing a nanochannel (200) is described with the following steps a) depositing a nanochannel sacrificial layer (3) using an ALD process on a substrate (1), which defines the subsequent channel height at least at one point b) depositing a first covering layer (4) on the nanochannel sacrificial layer (3) c) At least partially structuring and / or etching the nanochannel sacrificial layer (3) and the first cover layer (4) so ​​that a first exposed region (10) is formed d) At least partial etching of the now exposed nanochannel sacrificial layer (3) with an etching rate < 100nm / min, preferably <10nm / min, and particularly preferably <5nm / min and even more preferably <2nm / min, so that an under-etched second exposed region (20) is formed which defines the channel width e) depositing a second cover layer (5) onto the first cover layer (4) and the first exposed region (10) so that the second exposed region (20) is sealed and forms a nanochannel (200).

The invention relates to the technical field of tobacco smoke analysis, and discloses a gas sensor for detecting the content of 3-vinylpyridine in real time and a preparation method of the gas sensor. In order to realize accurate detection of tobacco smoke in the environment, 3-vinylpyridine in environmental gas is taken as a detection object, a SnO2 nanofiber material is further taken as a gas sensitive element, the detection sensitivity of the 3-vinylpyridine is remarkably improved, the SnO2 nanofiber material is arranged on the heating substrate, and the gas sensitive element is arranged on the heating substrate. The gas sensor generates a resistance change signal which linearly changes along with the change of the content of 3-vinylpyridine, so that the environmental tracing of the tobacco smoke is realized. Therefore, the invention provides the gas sensor with high sensitivity and high accuracy for tobacco smoke environment tracing.

The invention belongs to the technical field of semiconductor oxide gas sensors, and particularly relates to an rGO / CuO / Li sensitive material, a preparation method thereof and application of the rGO / CuO / Li sensitive material in H2S sensors. The preparation method comprises the following steps: firstly, preparing a graphene oxide nanosheet by using an improved Hummers method, and then preparing the rGO / CuO / Li sensitive material by using copper nitrate, lithium chloride and the prepared graphene oxide nanosheet as raw materials, polyvinylpyrrolidone as a surfactant and N, N-dimethylformamide as a solvent by using a one-step solvothermal method. Under the condition of room temperature, the sensitive material shows a relatively high response value (220.1) and a relatively low detection lower limit (1ppb) on hydrogen sulfide, has good selectivity, repeatability and stability, and has a wide application prospect in trace-level hydrogen sulfide detection in the fields of industrial safety and atmosphere detection.

The invention belongs to the field of antibiotic detection and biosensors, and particularly relates to a colorimetric array sensor for distinguishing different types of antibiotics based on platinum-based nano-enzyme and a detection method of the colorimetric array sensor. The colorimetric array sensor is composed of platinum nano-enzymes with three different structures, namely platinum nano-particles PtNPs, platinum nano-flowers PtNFs and gold-core platinum-shell nano-particles Au (at) PtNPs. According to the antibiotic detection method based on the platinum nano-enzyme colorimetric array sensing system, the peroxidase-like activity of the antibiotics is regulated and controlled through the non-specific interaction of the three platinum nano-enzymes (PtNPs, PtNFs and Au-coated PtNPs) and the antibiotics, a unique'fingerprint 'map is generated in combination with TMB-H2O2 chromogenic reaction, and efficient distinguishing and concentration detection of various antibiotics are achieved.

The invention relates to the technical field of biological medicine, in particular to a diagnosis and treatment integrated brain-targeted magnetic particle imaging tracer and a preparation method and application thereof. The preparation method comprises the following steps: loading tetrahydrocurcumin into glucan by adopting a nano-particle self-assembly technology to form glucan nano-particles loaded with tetrahydrocurcumin, synthesizing Fe3O4 nano-particles by adopting a chemical precipitation method, and embedding the Fe3O4 nano-particles on the glucan nano-particles to obtain the diagnosis and treatment integrated brain-targeted magnetic particle imaging tracer agent. The nano-particles are marked as THC (at) Dex-Fe3O4 nano-particles. The THC-Dex-Fe3O4 nanoparticles play a role in treating the Alzheimer's disease during brain imaging diagnosis, and the technical problems that magnetic particle imaging cannot be applied to diagnosis of the Alzheimer's disease and the Alzheimer's disease is difficult to treat are solved.

The invention belongs to the technical field of SERS (Surface Enhanced Raman Scattering) detection, and relates to a preparation method of an Ag-Fe3O4 composite SERS substrate and application of the Ag-Fe3O4 composite SERS substrate in monitoring trace pollutants in water. Based on a plasma-semiconductor synergistic enhancement mechanism, cubic Fe3O4 nano particles with exposed {100} crystal faces are synthesized through a hydrothermal method, and the cubic Fe3O4 nano particles and Ag nano particles are subjected to ultrasonic-stirring to construct the Schottky heterojunction. The substrate creatively realizes dual-channel enhancement: the local surface plasmon resonance effect of Ag nanoparticles generates electromagnetic enhancement, the narrow band gap of Fe3O4 promotes photo-induced electrons to be transferred to Ag, an interface electric field is formed, and the polarizability of adsorption molecules is remarkably increased. When the probe is applied to detection of trace pollutants in a water body, the probe molecule RB is anchored on the surface of Fe3O4 through carboxyl, and the HOMO energy level of the probe molecule RB and the valence band top of Fe3O4 generate resonance charge transfer, so that the Raman cross section is improved. The detection limit of RB under 0.25 mW laser is increased by several orders of magnitude compared with that of a single Ag substrate.

The invention discloses a flexible substrate material doped with a two-dimensional material and a preparation method of a sensor of the flexible substrate material, and belongs to the technical field of array sensors. The electrode material comprises a two-dimensional material substrate, a composite doping atom layer and an insulation isolation layer, high-density defect sites are formed through H2 plasma processing, uniform distribution of doping atoms is achieved in combination with atomic layer deposition, and an electrode and a temperature-sensitive layer are precisely integrated through the self-alignment photoetching technology. According to the scheme, the electronic structure of the two-dimensional material is optimized through the composite doping synergistic effect, the multi-layer heterojunction design and the high-precision preparation process are combined, the response capacity of the electrode to weak pressure signals is remarkably improved, and high resolution and stability of the sensor in pressure and temperature detection are achieved. The method has a wide application prospect in the fields of wearable equipment, medical monitoring, robot tactile perception and the like.

A MEMS gas sensor and a preparation method therefor, comprising an insulating substrate (1), a heating electrode (403), an insulating layer (105) and a testing unit, which are overlappingly disposed. The testing unit comprises a testing electrode, a sensing unit (2), and a selective separation membrane (3); the sensing unit (2) has a nanowire array structure formed by multiple nanowires disposed at intervals, and the selective separation membrane (3) covers the surface of the sensing unit and a recessed portion; the nanowires comprise a first metal and a second metal, the first metal being Pd, and the second metal being at least one selected from Ni, Cu, Ag, Au and Ir; the selective separation membrane (3) comprises an inner separation membrane (301) and an outer separation membrane (302) which are stacked in sequence; the inner separation membrane (301) comprises polytetrafluoroethylene, and the outer separation membrane (302) is a mixed matrix membrane having a covalent organic framework material as a filler and a polymer of intrinsic microporosity as a matrix. The MEMS gas sensor possesses excellent sensitivity for low-concentration gas monitoring, and tolerance stability for high-concentration gas, as well as excellent anti-interference performance and response speed.

A method of transporting atoms within an optical lattice may include: interfering two opposing laser beams whose focal points overlap with one another to form an optical lattice; and transporting one or more atoms by: translating the phase of the optical lattice; and translating the foci of the two opposing laser beams.

The invention discloses iron oxide nanoparticles capable of responding to particle size change in a tumor microenvironment and a preparation method of the iron oxide nanoparticles, and belongs to the technical field of biomedical nano materials. The nano-particle comprises an iron oxide nano-crystal core with the particle size of 3-5nm and a tumor microenvironment response layer coating the surface of the iron oxide nano-crystal core. The response layer contains groups, such as disulfide bonds, enzyme digestion peptide fragments and the like, which can respond to acidic pH, high-concentration reduced glutathione or matrix metalloproteinase and other tumor characteristic stimuli to generate structural changes. In a tumor microenvironment, the hydration particle size of the nanoparticles can be directionally and controllably converted from 3-20 nm to 20-100 nm (or reversely). The preparation method mainly comprises two steps of preparing the core by a thermal decomposition method and modifying the surface response layer. The technical problems of insufficient tumor targeted enrichment capacity, limited imaging contrast and difficulty in balancing permeation and retention caused by fixed particle size of the existing iron oxide nanoparticles are solved, and the accuracy and efficiency of tumor diagnosis and treatment can be remarkably improved.

The invention relates to the technical field of gas sensors for detecting H2S at room temperature, in particular to a preparation method of a high-sensitivity MoSe2-based gas sensitive material for detecting H2S at room temperature. The high-sensitivity MoSe2-based gas sensitive material for detecting H2S at room temperature is prepared by synthesizing MoSe2 nanoflowers by adopting a hydrothermal method and uniformly loading In2O3 nanoparticles on the surfaces of the MoSe2 nanoflowers by adopting a mechanical mixing method. The preparation method is simple and convenient in process and low in cost, the MoSe2 / In2O3 composite material prepared by the method has a relatively high specific surface area, and an II-type p-n heterojunction interface formed by the composite material effectively promotes separation and migration of current carriers. The response to 0.05 ppm H2S, 0.1 ppm H2S, 0.25 ppm H2S, 0.5 ppm H2S and 1ppm H2S at room temperature (the gas response is calculated according to the formula R = (Rg-Ra) / Ra) is 1.37, 1.47, 1.85, 2.74 and 4.82 respectively, the response is far better than that of an existing pure-phase MoSe2 gas sensitive material, and the working temperature is lower than that of an In2O3 pure-phase material. The research provides an effective method for constructing a gas sensitive material with a large specific surface area and II type p-n heterojunction, and further promotes the development of a gas sensitive technology.

The invention discloses a miniaturized monolithic integration method of a geomagnetic sensor and an MCU (Microprogrammed Control Unit). The method comprises the following steps of (1) low-temperature CMOS circuit layer preparation, (2) TSV three-dimensional interconnection structure processing, (3) magnetic-core-free planar coil manufacturing, (4) low-temperature electromagnetic shielding layer integration and (5) structure release and vacuum packaging. Process conflicts and hysteresis errors introduced by ferromagnetic materials are eliminated through a non-magnetic-core design, a TSV (through silicon via) three-dimensional interconnection technology is adopted to replace traditional plane wiring, the size of the module is compressed to the millimeter level, meanwhile, a broadband electromagnetic shielding layer is integrated, and it is ensured that in a weak magnetic field (lt; and the signal-to-noise ratio in a detection scene is greater than or equal to 30dB. The low-temperature compatibility with a CMOS (complementary metal oxide semiconductor) process can be realized, the mass production feasibility needs to adapt to a standard semiconductor production line, the cost of a single chip is reduced by more than 30%, and the method is suitable for navigation equipment, consumer electronics and industrial sensing systems.

One aspect of the present disclosure pertains to a device. The device includes a substrate, a logic circuit disposed on the substrate, and a nanoelectromechanical systems (NEMS) device electrically connected to the logic circuit and formed on the substrate. The NEMS device includes a first electrode electrically connected to the logic circuit, a second electrode electrically connected to a first power supply, a movable feature electrically connected to the second electrode, and a control electrode operable to move the movable feature relative to the first electrode.

The invention belongs to the field of synthesis of luminescent materials, and relates to a preparation method and application of a zero-dimensional manganese-based hybrid halide nanofiber membrane with reversible photoluminescence and radiation luminescence conversion. The synthetic route is as follows: preparing a precursor from 4-dimethylaminopyridine (DMAP) and hydrochloric acid, then synthesizing zero-dimensional organic-inorganic metal chloride with manganese chloride hydrate (MnCl2. 4H2O) and anhydrous manganese chloride (MnCl2), further mixing the zero-dimensional organic-inorganic metal chloride with polyvinylidene fluoride (PVDF), and performing electrostatic spinning to obtain a nanofiber film; compared with the prior art, the stimuli-responsive reversible PL switch flexible fiber membrane prepared by adopting an electrostatic spinning technology has excellent stability and PL switch performance, and can show efficient PL and RL switching under external stimuli. Meanwhile, the flexible nanofiber film produced by the method has the advantages of one-step synthesis, quick response, repeatability, good portability and low cost, so that the flexible nanofiber film becomes a new application of molecular-level dynamic photonic devices for data storage, information security, optical logic gates, flexible X-ray imaging and the like.

The application belongs to the technical field of food safety detection, and specifically discloses a method for detecting BaP in edible oil by using CTAB modified silver nanomaterial based on LLE-SERS, which comprises the following steps: preparing Ag nanoparticle sol, preparing CTAB functionalized Ag nanoparticle sol, SERS detection of BaP standard aqueous solution with different concentrations, fitting a standard curve, extracting BaP and performing SERS detection. The synthetic raw materials of the surface CTAB functionalized Ag nanoparticles used in the application are simple, and the coverage degree of the ligand molecules CTAB on the surface of the Ag nanoparticles can be controlled and adjusted. The CTAB as the surface ligand can directly capture and enrich BaP molecules. The detection method is high in stability, and can effectively avoid the problem that different batches of samples produce different effects in the Raman test.

This application provides a perovskite-crystalline silicon tandem solar cell and its preparation method. In one implementation, a perovskite-crystalline silicon tandem solar cell includes a crystalline silicon solar cell, a serial connection structure layer, a first carrier transport layer, a perovskite light absorption layer, a second carrier transport layer, and an upper transparent electrode layer. The first carrier transport layer includes a base layer and resistance-increasing nano structures distributed on the base layer. The resistance-increasing nano structures are integrally formed with the base layer. The resistance-increasing nano structures extend from the carrier transport layer base layer into the perovskite light absorption layer.

The invention discloses a method for preparing a two-dimensional material with a wrinkle structure under the assistance of liquid metal and application, and belongs to the field of micro-nano machining of two-dimensional materials. The method comprises the following steps: S1, covering the upper surface of a two-dimensional material with liquid metal gallium, and solidifying the liquid metal gallium under a cooling condition to obtain a metal gallium ingot loaded with a two-dimensional material nanosheet; s2, heating the metal gallium ingot loaded with the molybdenum disulfide nanosheet until gallium is molten, cooling and solidifying, and obtaining a two-dimensional material with a wrinkle structure after solidification; the method disclosed by the invention can be used for efficiently preparing the large-area and high-density wrinkle type two-dimensional material, is suitable for manufacturing devices such as high-performance sensors and has a wide application prospect.