589results about "Nanosensors" patented technology

The invention relates to the technical field of nano-probe detection, and particularly discloses a nano-probe test system for feeding back contact force in real time, comprising the following modules: a probe execution module comprising a nano-probe and a piezoelectric ceramic driver, the nano-probe realizing three-dimensional micro-displacement and establishing controllable contact with a wafer; the multi-dimensional signal sensing module is used for synchronously acquiring a contact resistance signal and a nanoprobe deformation signal; the data processing and control module is used for realizing signal analysis, force value calculation and driving control of a contact resistance signal and a nanoprobe deformation signal; the man-machine interaction module comprises a touch display screen and a real-time data recorder and is used for realizing visualization of force signals; the data processing and control module carries out cooperative analysis on the contact resistance signal and the nanoprobe deformation signal obtained by the multi-dimensional signal sensing module to obtain the real-time contact force of the nanoprobe and the wafer. The system solves the problem that a traditional nanoprobe detection system cannot feed back the contact force in real time.

The invention relates to a metallized microbubble and a preparation method thereof, a construction method of a multifunctional composite probe, and a rapid bacterium capturing and sterilizing method, and belongs to the technical field of functional material preparation. The method aims at solving the technical problems that in the prior art, a metal coating on the surface of the hollow glass microbubble is not uniform, combination is not firm, and stability is poor. According to the technical scheme, the method is characterized by comprising the following steps: mixing surface-activated hollow glass microbubbles with a polyethyleneimine solution for reaction, and washing and drying to obtain polyethyleneimine-coated hollow glass microbubbles; then reacting with a single-stranded DNA buffer solution to obtain an intermediate product loaded with DNA; then introducing a silver nitrate solution to load silver ions on the surface of the compound; and finally, reducing through a sodium borohydride solution to prepare the metallized microbubbles. The metalized microbubbles prepared by the method can be used for constructing a multifunctional composite probe to realize efficient capture and synergistic antibiosis of targets such as bacteria.

The invention discloses construction and application of a confinement enhanced photoelectrochemistry-electrochemiluminescence dual-mode biosensor, and relates to the technical field of biosensing and analytical chemistry. The preparation method of the biosensor comprises the following steps: taking a CdS (at) SiO2 (at) NaYF4: Yb / Tm nano composite material as a substrate to obtain a confinement enhanced photoelectrochemistry (PEC) and electrochemiluminescence (ECL) sensing interface; in combination with a DNA wheel nanostructure triggered by target acetamiprid, signal amplification is realized; and synchronous dual-mode quenching detection of PEC and ECL signals is realized by virtue of peroxidase-like catalytic precipitation and wide-spectrum absorption characteristics of the PtPd-CoSnO3 nanocube. The biosensor prepared by the invention has the advantages of high sensitivity, strong reliability, good selectivity and the like, can be applied to accurate detection of acetamiprid in samples such as agricultural products and the like, and has important application value in the aspects of environmental monitoring and food safety control.

An apparatus for transmitting heat from a component side to a radiator side on a spacecraft includes a component side that contains a heater, an electrical component, an optional first conduction link, and a first portion of a switchable thermal link and a radiator side that includes a radiator, an optional second conduction link and a second portion of a switchable thermal link. The first portion of the switchable thermal link and the second portion of the switchable link are in operative thermal communication with the component side and the radiator side respectively. The first portion of the switchable thermal link and the second portion of the switchable thermal link are reversibly attachable and detachable. The switchable thermal link is operative to receive and radiate thermal energy from the component side to the radiator side.

The invention belongs to the technical field of SERS (Surface Enhanced Raman Scattering) detection, and relates to a preparation method of an Ag-Fe3O4 composite SERS substrate and application of the Ag-Fe3O4 composite SERS substrate in monitoring trace pollutants in water. Based on a plasma-semiconductor synergistic enhancement mechanism, cubic Fe3O4 nano particles with exposed {100} crystal faces are synthesized through a hydrothermal method, and the cubic Fe3O4 nano particles and Ag nano particles are subjected to ultrasonic-stirring to construct the Schottky heterojunction. The substrate creatively realizes dual-channel enhancement: the local surface plasmon resonance effect of Ag nanoparticles generates electromagnetic enhancement, the narrow band gap of Fe3O4 promotes photo-induced electrons to be transferred to Ag, an interface electric field is formed, and the polarizability of adsorption molecules is remarkably increased. When the probe is applied to detection of trace pollutants in a water body, the probe molecule RB is anchored on the surface of Fe3O4 through carboxyl, and the HOMO energy level of the probe molecule RB and the valence band top of Fe3O4 generate resonance charge transfer, so that the Raman cross section is improved. The detection limit of RB under 0.25 mW laser is increased by several orders of magnitude compared with that of a single Ag substrate.

The invention discloses iron oxide nanoparticles capable of responding to particle size change in a tumor microenvironment and a preparation method of the iron oxide nanoparticles, and belongs to the technical field of biomedical nano materials. The nano-particle comprises an iron oxide nano-crystal core with the particle size of 3-5nm and a tumor microenvironment response layer coating the surface of the iron oxide nano-crystal core. The response layer contains groups, such as disulfide bonds, enzyme digestion peptide fragments and the like, which can respond to acidic pH, high-concentration reduced glutathione or matrix metalloproteinase and other tumor characteristic stimuli to generate structural changes. In a tumor microenvironment, the hydration particle size of the nanoparticles can be directionally and controllably converted from 3-20 nm to 20-100 nm (or reversely). The preparation method mainly comprises two steps of preparing the core by a thermal decomposition method and modifying the surface response layer. The technical problems of insufficient tumor targeted enrichment capacity, limited imaging contrast and difficulty in balancing permeation and retention caused by fixed particle size of the existing iron oxide nanoparticles are solved, and the accuracy and efficiency of tumor diagnosis and treatment can be remarkably improved.

The present invention relates to a ligand exchange technique for III-V group colloidal quantum dots. By employing a ligand surface treatment method, the invention facilitates the ligand exchange process in III-V group quantum dots while enhancing their solvent dispersibility. Furthermore, by substituting heterogeneous ligands, the invention enables the production of quantum dot ink based on environmentally friendly solvents and its application in device fabrication. Accordingly, the present invention proposes III-V group colloidal quantum dots incorporating heterogeneous ligands, a method for manufacturing environmentally friendly solvent-based quantum dot ink, and an optoelectronic device utilizing the ink.

The present invention relates to novel pore monomer conjugates, pore complexes formed from the conjugates and their uses in analyte detection and characterisation.

The application belongs to the technical field of precision positioning, and discloses a large-stroke macro-micro integrated two-stage differential nanometer motion positioning platform and a control method. The positioning platform comprises a base, a driven input module, a driving input module, a driven platform, a flexible displacement reduction mechanism, a positioning platform, a driving platform and a total controller. The driving input module and the driven input module are connected with the driving platform and the driven platform. The fixed end of the flexible displacement reduction mechanism is fixedly connected with the driven platform, the input end of the flexible displacement reduction mechanism is fixedly connected with the driving platform, and the output end of the flexible displacement reduction mechanism is fixedly provided with the positioning platform. The total controller is electrically connected with the driving input module and the driven input module, and is used for sending a motion control signal to the driving input module and the driven input module. Macro motion and micro motion of the motion positioning platform are realized through the same direction and differential driving of the driving input module and the driven input module, and the positioning platform has the characteristics of large stroke and high precision.

A chemiluminescent nanoconstruct is described herein. The chemiluminescent nanoconstruct structure may comprise a plasmon nanostructure having at least one localized surface plasmon resonance wavelength ([lambda] LSPR), at least one spacer coating, at least one chemiluminescent agent having a maximum emission wavelength ([lambda] EM), and at least one biorecognition element. The signal of the chemiluminescent nanoconstruct structure is greater than the signal of only the at least one chemiluminescent agent.

The invention discloses a preparation method of an MF (at) NH2 (at) Ag SERS (Surface Enhanced Raman Scattering) sensor for detecting paraquat and diquat, belongs to the field of nano material synthesis and spectral analysis, and solves the problems that a traditional detection method is complicated in process and cannot detect pesticides and free radicals thereof at the same time, and a traditional SERS substrate is poor in enhancement effect and low in stability. The preparation method comprises the following steps: firstly segmenting melamine foam, cleaning and drying, soaking in hydrochloric acid, soaking in a polyethyleneimine aqueous solution to modify amino, drying, soaking in a silver nitrate solution for ultrasonic treatment, adding a sodium borohydride solution under an ice bath, stirring and reducing, and finally cleaning and drying to obtain the sensor. The sensor takes three-dimensional melamine foam as a support, silver nanoparticles are uniformly loaded on the surface of the three-dimensional melamine foam, paraquat, aquacide and free radicals thereof are enriched through electrostatic interaction based on a localized surface plasma resonance principle, and Raman signal enhancement is realized. The detection limit is 10 <-9 > mol / L, the signal stability and repeatability are excellent, the applicability to actual water sample detection is good, the detection of other pesticides can be expanded, and the method is suitable for on-site rapid trace detection.

An example of a genotyping or sequencing platform generally includes a negatively-charged substrate including a plurality of depressions defined therein that are separated by interstitial regions. The genotyping or sequencing platform further includes an exposed passivation layer positioned over an entirety of a surface of the negatively-charged substrate, wherein the exposed passivation layer at least partially fills each depression in the plurality of depressions and at least partially overlies each interstitial region across the entirety of the surface.

The purpose of one aspect of the present invention is to provide fluorescent particles having excellent dispersibility. One aspect of the present invention relates to a fluorescent particle (100) having: a core particle (10A) with a first charge, the first charge being a positive charge or a negative charge; at least one polymer layer (12) and at least one fluorescent layer (11A, 11B) on the core particle, the polymer layer containing a polymer and carrying a second charge, the second charge being a positive charge or a negative charge; and a fluorescent layer containing metal nanoclusters (13) having fluorescent properties and carrying a third charge, the sign of which is opposite to that of the second charge.

A method of surface-enhanced Raman spectroscopy includes positioning an analyte in a field-enhancing region of a nanophotonic element, irradiating the analyte with a continuous wave excitation laser operating at a user-defined frequency in a range from near infrared (NIR) to short-wave infrared (SWIR) to generate a signal to cause photon scattering from the analyte and detecting the photons with one or more photodetectors in the SWIR. A surface-enhanced Raman spectroscopy system includes a laser operating at a frequency having a range from near-infrared (NIR) to short-wave infrared (SWIR) that emits light in a spectrum between 700 and 2500 nanometers, a nanophotonic element to receive the light from the laser, and one or more SWIR detector to detect photons scattered by an analyte on the nanophotonic element.

The invention belongs to the field of metal oxide semiconductor-gas sensing, and particularly relates to a Ni < x > Fe < 2-x > O semiconductor gas-sensitive material with asymmetric defects, a preparation method and application, the sensing material is characterized in that Ni is doped in a Fe2O3 framework to form a Ni < x > Fe < 2-x > O bimetallic oxide rich in Ni-Ov-Fe asymmetric defects, Ni is used as a main active site for adsorbing and catalyzing NO2, and the Ni is used as a main active site for adsorbing and catalyzing NO2. And with the mutual reaction with active oxygen on asymmetric defects on the surface of the material, the sensing performance on NO2 is improved. The Ni < x > Fe < 2-x > O sensing material is prepared through a hydrothermal-calcination method, the interaction between Ni element and other atoms in a Fe2O3 frame is remarkable, and the electron transmission capacity is improved. The material is clear in labor division in the NO2 sensing process, NO2 and O2 have respective adsorption activation sites, then reaction is carried out, excellent NO2 sensing response performance and extremely low detection limit (200 ppb) are shown, and a good foundation is laid for development of novel metal oxide semiconductors.

The invention discloses an Au (at) PtNCs nano-enzyme probe for detecting novel nicotine pesticides as well as a preparation method and application of the Au (at) PtNCs nano-enzyme probe, and belongs to the field of rapid detection of biosensors. The invention provides an Au (at) PtNCs nano-enzyme probe, which is generated by combining AuNCs and PtNCs and coupling with a second antibody, and can effectively realize rapid specific detection of novel nicotine pesticides such as imidacloprid and the like. The linear range of the biosensor probe for detecting the imidacloprid pesticide is 0.1-100 [mu] g / L, and the limit of detection (LOD) can reach 0.127 [mu] g / L and 0.119 [mu] g / L respectively by combining a colorimetric method and a fluorescence method.

The present invention broadly relates to the fabrication and processing of graphene electronic devices on silicon which comprise a silicon dioxide passivation layer.

A system executes a search to tune dimensions and distribution of meta-atoms in the passive acoustic metasurface with respect to a plurality of predefined input signal property sets of the acoustic signal to provide a tuned propagation profile of the meta-atoms in aggregate and forms the meta-atoms with the dimensions and the distribution. Each meta-atom modulates incoming acoustic wavefronts to form corresponding outgoing acoustic wave exiting the passive acoustic metasurface. The tuned propagation profile in aggregate supports the plurality of predefined input signal property sets of the incoming acoustic wavefronts and, for each input signal property set. The physical dimensions and the distribution of the meta-atoms are tuned according to the tuned propagation profile to modulate the incoming acoustic wavefronts to generate a predefined beam pattern of the acoustic signal exiting the passive acoustic metasurface corresponding to a select input signal property set of predefined input signal property sets.

A system for viral monitoring in effluent includes at least one graphene-based field-effect transistor and circuitry, wherein the circuitry is configured to repeatedly monitor and determine presence of SARS-CoV-2 (COVID virus) in the effluent. The circuitry is configured to apply a gate voltage and measure a conductance across each of the at least one graphene-based field-effect transistor, compare the measured conductance across each of the at least one graphene-based field-effect transistor to a threshold conductance, and determine whether levels of the COVID virus exceed a predetermined threshold in the effluent. If levels of the COVID virus exceed the predetermined threshold in the effluent, the circuitry is configured to remove at least a portion of the bound COVID virus from the proteins of the at least one graphene-based field-effect transistor.

The disclosure describes sequencing workflows and reagents used in those workflows that are suitable for sequencing a target nucleic acid using a nanopore sequencing device. The disclosure also describes detergent and air-flow based methods and compositions used to clean a device pre- and post-sequencing to enable reuse of a consumable device in a nanopore sequencer.

The present application belongs to the technical field of biological medicine, and particularly relates to a thiol phenylboronic acid mediated nano-enzyme immunochromatography reagent and application thereof. The present application utilizes the broad-spectrum binding ability of MPBA to the glycosylated molecules on the surface of pathogens, and combines the colorimetric catalytic double enhancement effect of the virus-like biomimetic magnetic nano-enzyme (FeAu@AuIr), to improve the detection sensitivity. The probe takes Fe3O4 magnetic nanoparticles as the core, and sequentially loads large-diameter gold nanoparticles (Au) and gold-iridium alloy (AuIr) with high catalytic activity, to enhance the pathogen capture capacity and signal amplification effect. Combined with the antibody modified immunochromatography strip, Streptococcus pneumoniae, Pseudomonas aeruginosa and SARS-CoV-2 can be simultaneously detected, and the detection sensitivity is greatly improved. Through verification of 170 clinical samples, the present application has good application prospect in on-site rapid detection, and provides an efficient and low-cost solution for precise screening of respiratory tract infectious pathogens.

The application provides a preparation method of bismuth nanoparticle material and application thereof, and dissolves bismuth nitrate pentahydrate in ethylene glycol to prepare a solution, then adds nitric acid to accurately adjust the pH value of the solution to 1.0; dissolves sodium citrate in ethylene glycol to prepare a solution; mixes the two solutions and uniformly mixes; transfers the mixed solution to a microwave reaction kettle, and under the condition that the temperature is 110-130 DEG C and the microwave power is 300-500 W, radiates and reacts for 20-40 min; cools to room temperature, and the obtained product is washed by centrifugation with ethanol for multiple times, and dried, to obtain black bismuth nanoparticles. The application accurately controls the acidic environment of the precursor solution by nitric acid, and utilizes the synergistic and co-reduction effect of sodium citrate and ethylene glycol to quickly and controllably reduce Bi 3+ to elemental Bi to form nanoparticles. The application has outstanding advantages in efficiency, controllability, environmental protection and cost.

This invention relates to the field of semiconductor technology, specifically to a molecular junction of a metal oxide semiconductor and its applications, wherein the molecular junction is composed of oxygen vacancies and hydroxyl groups, which are bonded to the same metal atom to form an oxygen vacancy-hydroxyl metal oxide molecular junction (Oxygen vacancy-hydroxyl metal oxide, V). O (-M-OH). The molecular junction of this invention can achieve efficient hole injection / transmission, optimize interface band arrangement, and effectively suppress dark current.

Disclosed herein are nanorod productions systems (NPS) useful for the production of biological scalable functionalization-ready nanorods (BSFnano). The nanorods produced are derived from filamentous phage Ff (f1, M13 or fd). The NPS disclosed herein permits efficient biological production of non-infectious, heat-stable isomorphic proteinaceous nanorods comprising modifications allowing site-specific recombinant, chemical and enzymatic attachment of peptide and non-peptide functionalities in an orthogonal manner. Also disclosed are methods of making and using these nanorods, such as in methods of detecting target molecules.

The invention discloses a p-type tungsten disulfide nanotube bundle, a preparation method thereof and application of the p-type tungsten disulfide nanotube bundle in a photoelectric detector with adjustable light response linearity, and the method comprises the following steps: depositing an Au film on a SiO2 / Si substrate, and carrying out annealing to form a zero-dimensional Au nanoparticle catalytic layer; the method comprises the following steps: respectively placing tungsten trioxide (WO3) powder and sulfur (S) powder in different areas of a single-temperature-area tubular furnace, heating to 850-1000 DEG C in an Ar / H2 mixed gas low-pressure atmosphere, and reacting to generate a WS2 nanotube bundle with a multi-wall hollow structure; the obtained material has a cluster-shaped morphology in dense interlaced distribution, and shows stable p-type conductive characteristics. A photoelectric detector prepared based on the material has high responsivity (2.7 * 10 < 4 > A / W), high detection rate (1.6 * 10 < 13 > Jones) and quick response (15 ms) in a wave band of 375-1550 nm, and keeps stable performance in a range of 10-300 K. The method is simple in process, the growth process of the tungsten disulfide nanotube bundle can be accurately controlled, the polarity of tungsten disulfide is changed to be p-type, and large-scale preparation can be achieved.

This invention discloses a three-dimensional graphene / metal composite material, its preparation method, and its application. The preparation method includes: laser treatment of a benzoxazine compound to obtain three-dimensional graphene; and electroplating with a mixture containing acetate, an organic solvent, and water as the electroplating solution, using the three-dimensional graphene as the working electrode, and applying a current density of 0.1 mA / cm². 2 ~3mA / cm 2 Electroplating was performed under specific conditions to obtain a three-dimensional graphene / metal composite material. The three-dimensional graphene / metal composite material prepared by this invention retains the porous structure of three-dimensional graphene and has excellent electrical conductivity, showing great promise for applications in electrochemical sensors, catalysis, supercapacitors, and other fields.

This document relates to methods and materials for detecting the presence or absence of misfolded polypeptides in a sample. For example, a sample (e.g., a biological sample or an environmental sample) can be exposed to nanoparticles (e.g., nanoparticles having a size of no more than 2 μm (e.g., no more than 1 μm) such as silica nanoparticles (siNPs) having a size of no more than 2 μm (e.g., siNPs having a size of no more than 1 μm)) during a seeded amplification assay to accelerate the aggregation of misfolded polypeptides present in the sample into fibrils and / or polypeptide aggregates (e.g., globular polypeptide aggregates). In some cases, methods and materials provided herein can be used to determine if a mammal (e.g., a human) has a proteinopathy based, at least in part, in the presence or absence of misfolded polypeptides in a sample obtained from the mammal.

An analyzer is disclosed for detecting and quantifying a glutaraldehyde (GLUT) composition in a water sample. The analyzer includes a peristaltic pump and a three-way valve, where the pump draws in a water sample comprising a GLUT composition through the 3-way valve. The analyzer also includes a 6-way valve that receives the water sample and a bovine serum albumin-coated gold (Au-BSA) nanoclusters reagent. The analyzer also includes: a debubbler that receive a mixture of the water sample and the reagent and removes bubbles from the mixture; and a reaction coil that receives the water sample and the reagent from the debubbler, such that they are reacted. The analyzer further includes a fluorescence flow cell that receives the reacted mixture; measures a fluorescence intensity of the Au-BSA nanoclusters in the mixture; and determines a concentration of the GLUT composition in the water sample based on the fluorescence intensity.

The invention belongs to the technical field of micro-nano machining, and particularly relates to a hollow metal nano array and a preparation method and application thereof. According to the invention, a regular polymer nano array is prepared based on an ultraviolet light curing nano imprinting technology and a plasma etching technology; then metal evaporation is carried out in combination with an electron beam evaporation dip angle evaporation process, so that the surface of the polymer nano array is partially coated with metal, and a polymer / metal composite nano array with a notch is obtained; and dissolving by using a solvent to remove the water-soluble polymer nano-columns in the polymer / metal nano-array with the notches, so as to prepare the large-area hollow metal nano-array of which the morphology, the size and the period can be flexibly designed. Sulfydryl benzaldehyde molecules are fixed on the surface of the hollow metal nano array to form an SERS (Surface Enhanced Raman Scattering) substrate which is used for detecting hydrazine hydrate. The SERS substrate prepared on the basis of the hollow metal nano array shows high sensitivity, specificity, repeatability and stability.

A system and method for sequestration and reduction of carbon dioxide (CO2) to a carbon material via an integrated microbial and chemical catalytic processes are described. The system and method comprise a bioreactor in gas communication with a pyrolysis reactor, wherein the microbes of the bioreactor uptake CO2 dissolved in aqueous solution and convert it to a volatile organic carbon compound, such as, for example, methane, which, in turn is fed into the pyrolysis reactor for catalytic conversion to a carbon material, wherein the carbon material may include crystalline carbon. The thus obtained carbon material is easily collectable for various high end uses or for CO2 storage.