78 results about "Microscope slide" patented technology

The invention provides a microscope automatic focusing method based on an end-to-end model, and relates to the technical field of optical instruments. The method comprises the following steps: shooting an image on a microscope glass slide through an image acquisition module, and carrying out image preprocessing through a gray histogram equalization algorithm; deploying an end-to-end neural network model at the cloud server, receiving the preprocessed image and predicting a first focusing position value; the first focusing position value is sent to an electric focusing module controlled by a stepping motor, and focusing is completed; and acquiring a second image, performing image preprocessing, predicting a second focusing position value by using the end-to-end neural network model, and sending a relative position between the second focusing position value and the first focusing position value to the electric focusing module to complete final automatic focusing. According to the method, the optimal focusing position is directly predicted from the microscopic image through the deep learning model, a traditional focusing scoring function or an image sequence analysis process is simplified, end-to-end efficient prediction is realized, and the focusing speed and precision are remarkably improved.

A system and method for dispense characterization is disclosed. According to particular embodiments of the dispense characterization system and method, volumes of dispensed liquids can be determined. In more particular embodiments, additional characteristics, and combinations of characteristics of a liquid dispensing event can be determined. Examples of additional characteristics that can be determined include the shape of the dispensing event, the velocity of the dispensing event, and the trajectory of the dispensing event. The dispense characterization system and method can be employed in automated biological sample analysis systems, and are particularly suited for monitoring liquid reagent dispensing events that deliver liquid reagents to a surface of a microscope slide holding a biological sample.

Systems and methods that enable automated processing of specimens carried on microscope slides are described herein. In some embodiments, the system can include, for example, a slide ejector assembly having a slide staging device configured to receive a slide and an over-travel inhibitor that includes a first vacuum port positioned to draw a first vacuum between the slide and a standby platform as the slide is moved across at least a portion of the standby platform. The over-travel inhibitor includes a first sensor for detecting a presence of the slide on the standby platform. The system can also include a transfer assembly to transport slides away from the slide ejector assembly. The transfer assembly can include a floating transfer head having a vacuum port for drawing a partial vacuum for holding the slide.

This invention provides a feeding mechanism for a biological tissue sample staining device, including a translational feeding assembly, a sample slide feeding lifting assembly, a sample slide feeding heating chamber, and a microscope slide vertical support. The translational feeding assembly has a translational feeding platform capable of holding multiple microscope slide vertical supports. Multiple microscope slides can be vertically fixed in an array within each microscope slide vertical support, with each slide spaced apart. The sample slide feeding lifting assembly cooperates with the translational feeding platform. The sample slide feeding heating chamber is positioned above the sample slide feeding lifting assembly, and the sample slide feeding lifting assembly can reciprocate between the translational feeding platform and the sample slide feeding heating chamber. The beneficial effect of this invention is that it can avoid the risk of cross-contamination between microscope slides.

To provide a slide glass capable of performing staining without peeling off a specimen when performing the staining by using an automatic staining device.SOLUTION: According to the present invention, there is provided a slide glass including a test region including an outer region and a smear region, in which the outer region is formed by performing an antifouling process on the slide glass, the smear region is shaped by being surrounded by the outer region and includes a specimen dropping portion and a staining liquid dropping portion, and the specimen dropping portion and the staining liquid dropping portion are arranged at different positions in the smear region.SELECTED DRAWING: None

A label for matrix tube may have a facestock configured to have data on a first surface thereof. An adhesive layer may be on a second surface of the facestock. The facestock may define an cover label portion, a main label portion and a neck portion between the cover label portion and the main label portion, the neck portion being narrower than the cover label portion and the main label portion. A method for applying a label onto a matrix tube may also be provided.

The utility model provides an automatic dyeing mechanism of biological tissue sample section dyeing equipment, which comprises an automatic dyeing glass slide feeding and clamping component, an automatic dyeing reaction disc and an automatic dyeing glass slide discharging and clamping component, a main console of the biological tissue sample section dyeing equipment is in control connection with an automatic dyeing glass slide feeding and clamping assembly, an automatic dyeing reaction disc and an automatic dyeing glass slide discharging and clamping assembly, the automatic dyeing reaction disc is provided with a plurality of dyeing grooves, and the dyeing grooves can be filled with dyeing reagents and are matched with microscope glass slides. The automatic dyeing glass slide feeding and clamping assembly and the automatic dyeing glass slide discharging and clamping assembly are both matched with the feeding and discharging temporary storage mechanism, and the feeding and discharging temporary storage mechanism can place a plurality of microscope glass slide vertical placing supports in an array mode. The microscope glass slide dyeing tank has the beneficial effects that the microscope glass slides can be separated by the dyeing tank for dyeing operation, so that cross contamination is avoided.

A system including: a carousel including a plurality of mounting stations dimensioned to receive at least one fluid dispensing cartridge; and a receiving assembly positioned beneath the carousel, the receiving assembly including a plurality of reaction stations, each of the plurality of reaction stations including: a body comprising a length dimension and a width dimension that together define a chamber to accommodate a single slide therein; and a lid comprising a first position to cover the chamber and a second position to expose a portion of the chamber. A method including moving a lid of a reaction station to expose a single microscope slide including a sample and dispensing one or more reagents on the sample.

Systems, methods, and apparatus for reverse marking a microscope sheet using a laser markable ink are described. In some embodiments, a laser markable ink may be applied to a first surface of a microscope sheet. A laser may be provided to a second surface opposite the first surface of the microscope sheet. The laser may pass through a thickness of the microscope sheet from the second surface to the laser markable ink disposed on the first surface. The laser may interact with the laser-markable ink to produce a chemical reaction that carbonizes the laser-markable ink to produce a color change of the laser-markable ink that is observable through the microscope sheet. Labels that can be observed through the microscope sheet can be produced by marking the laser markable ink.

A sample processor including a body including an inner surface that defines a chamber including an opening in a side of the body and including a volume to accommodate a least one microscope slide therein; a door comprising a first position to cover the opening of the body and a second position to expose a portion of the chamber through the opening; a slide bed disposed in the chamber; one of an internal humidity generator disposed in the chamber and an external humidity generator coupled to the chamber. A system including at least one sample processor at least one reagent outside the body of the at least one sample processor and a method including subjecting a sample on a microscope slide in a sealed chamber to a pressure greater than ambient and a humidity greater than 60 percent; and processing the sample. 20 25 20 31 55 02 M ay 2 02 5 A B S T R A C T 2 0 2 5 2 0 3 1 5 5 0 2 2 0 2 5 M a y

A slide imaging device (110) for digital morphology in hematology is disclosed, comprising at least one z-axis stage (112) configured to place a microscope slide (114) at a sample plane, wherein a biological sample may be placed on the microscope slide (114), wherein the z-axis stage (112) is configured to set a relative distance along the optical axis (118) of the slide imaging device (110) between the microscope slide (114) and the imaging system (116) of the slide imaging device (110). The slide imaging apparatus (110) further includes at least one sample beam path and at least one autofocus beam path, the at least one autofocus beam path including at least one pattern illumination source (132), the at least one pattern illumination source including at least one light emitter (134) and at least one grating (136), wherein the grating (136) is tilted relative to the optical axis (118) of the slide imaging apparatus (110), wherein the autofocus beam path includes at least one second transmission system (140) and at least one autofocus camera (138), wherein the second transmission system (140) is configured to allow a pattern generated by the pattern illumination source (132) to be projected onto the sample plane and to allow a pattern reflected from the sample plane to be propagated to the autofocus camera (138), wherein the autofocus camera (138) is configured to generate at least one digital autofocus image of the pattern reflected from the sample plane. The slide imaging apparatus (110) further includes at least one processing unit (148) configured to analyze the digitally autofocused image, wherein the analysis includes spatial analysis of contrast and determination of the image location with maximum contrast. The slide imaging apparatus (110) further includes at least one control unit (150) configured to control the z-axis stage (112) taking into account the determined image location to position the microscope slide (114) along the optical axis (118) of the slide imaging apparatus (110).

Microscope slide (100, 101, 102, 200, 300, 400) comprising: a transparent planar substrate (10, 30) for holding a sample (52), the substrate (10, 30) having at least one input port configured for receiving a light beam from a fiber (11, 21, 31) external to the substrate (10, 30); at least one optical circuit (12, 13, 14, 15, 16, 17, 18, 19, 20, 20', 22, 23, 23', 23'', 24, 24', 24'', 25, 25', 25'', 26, 26', 26'', 27, 27', 28, 29, 29', 29'', 31, 31', 32, 32', 33, 33', 41, 41', 42, 42', 43, 44, 45, 46, 47, 48, 49, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 170, 171, 172, 173, 174, 175) housed in the substrate (10, 30); said at least one optical circuit (12, 13, 14, 15, 16, 17, 18, 19, 20, 20', 22, 23, 23', 23'', 24, 24', 24'', 25, 25', 25'', 26, 26', 26'', 27, 27', 28, 29, 29', 29'', 31, 31', 32, 32', 33, 33', 41, 41', 42, 42', 43, 44, 45, 46, 47, 48, 49, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 170, 171, 172, 173, 174, 175) is configured for being coupled with the input port and for transforming the light beam in a structured illumination pattern outside the substrate (10, 30), the pattern having a cartesian component orthogonal to the substrate (10, 30).

Various examples of systems and methods are provided for imaging calibration for slide processing. In one example, among others, a system for processing microscope slides includes a light source; an imaging device comprising a lens; and a slide positioner that can position the ground-glass portion of a slide between the light source and lens. Processing circuitry of the system can acquire an image of at least a section of the ground-glass portion at an initial position; analyze contrast of adjacent pixels with respect to a defined contrast characteristic; iteratively advance the lens and acquire additional images based upon analysis of contrast of adjacent pixels with respect to the defined contrast characteristic; and identify an optimal focal location of the lens based upon the defined contrast characteristic. Subsequent image acquisition via the lens can be based at least in part upon the optimal focal location.

Various examples of systems and methods are provided for imaging calibration for slide processing. In one example, among others, a system for processing microscope slides includes a light source; an imaging device comprising a lens; and a slide positioner that can position the ground-glass portion of a slide between the light source and lens. Processing circuitry of the system can acquire an image of at least a section of the ground-glass portion at an initial position; analyze contrast of adjacent pixels with respect to a defined contrast characteristic; iteratively advance the lens and acquire additional images based upon analysis of contrast of adjacent pixels with respect to the defined contrast characteristic; and identify an optimal focal location of the lens based upon the defined contrast characteristic. Subsequent image acquisition via the lens can be based at least in part upon the optimal focal location.

Histology laboratories in hospitals and elsewhere require significant amounts of manual work. These labs also have to contend with rising workloads and increasing work complexity. Current labor vacancy rates are about 10-12%. and it has been predicted that the retirement rate in these work environments will be about 18-36% within the next 5 years. Within these labs, microscope slide cleaning in preparation for scanning and / or pathologist review is often a tedious task. Typically, the slide cleaning process requires manual application of cleaning fluids and wiping of slides with lens paper to remove dust, fingerprints, specks, and the like. Leaving these contaminants on the slide can lead to out of focus image sections which increases the risk of obscuring diagnostically relevant information. Thus, there is a need for improvement in this field.

Apparatus for positioning a microscope slide and comprising co-acting first and second clamping jaws attached to a robot arm and adapted to receive and carry a microscope slide.

Systems, methods, and devices for providing an extraction and filtration technique for polluted air output from a laser printing system. The extraction and filtration technique including a plenum proximate to a printing or marking area of the laser printing system for receiving emissions output from the laser printing system and containing polluted air comprising the emissions to reduce a volume of polluted air, one or more filters for filtering emissions from the polluted air, and a fan assembly in fluid communication with the plenum extracting the polluted air to flow a stream of the polluted air from the plenum and through the one or more filters to filter at least a portion of the particulate matter and volatile organic compounds from the polluted air to produce filtered air.

A microscope slide-holder support having a plate-shaped body defining an upper body surface, an opposite lower body surface, and a body thickness defined between the upper body surface and the lower body surface is provided. The plate-shaped body has a through opening passing through the plate-shaped body between the upper body surface and the lower body surface, at least one slide seat to removably house a corresponding microscope slide at the upper body surface, and upper removable engagement means for engaging / disengaging the microscope slide to / from the plate-shaped body at a respective slide seat. The microscope slide-holder support has a collection plate coupable to the plate-shaped body for at least partially closing the through opening close to the lower body surface, the collection plate and the through opening being configured to jointly form a collection compartment in the microscope slide-holder support.

A system including: a carousel including a plurality of mounting stations dimensioned to receive at least one fluid dispensing cartridge; and a receiving assembly positioned beneath the carousel, the receiving assembly including a plurality of reaction stations, each of the plurality of reaction stations including: a body comprising a length dimension and a width dimension that together define a chamber to accommodate a single slide therein; and a lid comprising a first position to cover the chamber and a second position to expose a portion of the chamber. A method including moving a lid of a reaction station to expose a single microscope slide including a sample and dispensing one or more reagents on the sample.

The present disclosure is useful for extraction and filtration of contaminated air in laser printing systems for microscope slides. Systems, methods, and apparatus are provided for providing extraction and filtration techniques for polluted air output from a laser printing system. The extraction and filtration technique includes: a plenum proximate to a printing or marking area of a laser printing system for receiving emissions output from the laser printing system and containing contaminated air containing the emissions to reduce the volume of the contaminated air; one or more filters for filtering emissions from the contaminated air, one or more filters for filtering emissions from the contaminated air; and a fan assembly in fluid communication with the plenum for extracting the contaminated air to cause a flow of the contaminated air to flow out of the plenum and through the one or more filters to filter at least a portion of the particulate matter and volatile organic compounds from the contaminated air to produce filtered air.

The utility model relates to the related technical field of detection platforms, in particular to a microscope detection platform which comprises a platform plate, a first connecting plate and a vertical rod are installed at the top end of the platform plate, the first connecting plate is rotationally connected with the bottom end of a telescopic piece, and the top end of the telescopic piece is rotationally connected with a second connecting plate. The top of the second connecting plate is connected with the bottom of an adjusting box, the top end of the vertical rod is rotationally connected with one end of the adjusting box through a third connecting plate, a clamping assembly is installed at the top of the adjusting box, and the position of the second connecting plate at the bottom of the adjusting box and the position of the clamping assembly at the top of the adjusting box can be adjusted through the adjusting box. The microscope lens can be rapidly clamped through the clamping assembly, and the clamped microscope lens can be better matched with detection equipment for quality detection work by adjusting the position and angle of the microscope lens.

A system comprising: a turntable including a plurality of mounting stations sized to receive at least one fluid dispensing cartridge; and a receiving assembly positioned below the turntable, the receiving assembly including a plurality of reaction stations, each of the plurality of reaction stations including: a body including length and width dimensions of a chamber together defining a cavity for receiving a single slide; and a cover including a first position covering the cavity and a second position exposing a portion of the cavity. A method comprising moving the cover of a reaction station to expose a single microscope slide containing a sample, and dispensing one or more reagents onto the sample.

Various examples of systems and methods for slide processing are provided. In one example, a system for processing microscope slides, among other things, includes a reservoir having a fluid and a treatment applicator capable of dispensing the fluid onto the slide. The treatment applicator can include an offset rail opposite an application surface, where the offset rail and application surface define a treatment channel when positioned on the surface of the slide and can include an opening capable of directing fluid into the treatment channel. The opening can include a constriction configured to regulate fluid flow into the treatment channel. In another example, a method includes positioning a slide adjacent to the treatment applicator and dispensing fluid into the treatment channel along the surface of the slide through an opening extending through the treatment applicator.

Various examples of systems and methods are provided for slide processing. In one example, among others, a system for processing microscope slides includes a slide positioner that can adjust a position of a slide and a slide treatment system that can dispense a micro stream of a fluid at a location on the slide when the slide is positioned beneath a jet nozzle of the slide treatment system. The system can include a slide sled that can align a smearing slide with a surface of the slide including a fluid sample is disposed, and support the smearing slide at a predefined angle with respect to the surface of the slide. In another example, a method includes obtaining a slide including a sample disposed on a surface, positioning the slide below to a jet nozzle, and dispensing a micro stream of a fluid onto the sample using the jet nozzle.

Various examples of systems and methods are provided for slide processing. In one example, among others, a system for processing microscope slides includes a slide positioner that can adjust a position of a slide and a slide treatment system that can dispense a micro stream of a fluid at a location on the slide when the slide is positioned beneath a jet nozzle of the slide treatment system. The system can include a slide sled that can align a smearing slide with a surface of the slide including a fluid sample is disposed, and support the smearing slide at a predefined angle with respect to the surface of the slide. In another example, a method includes obtaining a slide including a sample disposed on a surface, positioning the slide below to a jet nozzle, and dispensing a micro stream of a fluid onto the sample using the jet nozzle.

A system including: a carousel including a plurality of mounting stations dimensioned to receive at least one fluid dispensing cartridge; and a receiving assembly positioned beneath the carousel, the receiving assembly including a plurality of reaction stations, each of the plurality of reaction stations including: a body comprising a length dimension and a width dimension that together define a chamber to accommodate a single slide therein; and a lid comprising a first position to cover the chamber and a second position to expose a portion of the chamber. A method including moving a lid of a reaction station to expose a single microscope slide including a sample and dispensing one or more reagents on the sample. 20 25 23 41 61 17 S ep 2 02 5 2 0 2 5 2 3 4 1 6 1 1 7 S e p 2 0 2 5 A B S T R A C T

A uniquely identifiable consumable product for use in a histology or cellular pathology process for processing a biological sample from a source, the consumable product having a unique identifier which is not linked to the source of the sample is provided. By applying a unique identifier to cassettes and other consumable products prior to use, laboratory printers for printing identification information on tissue processing cassettes and on microscope slides and the like are redundant. The unique identifier is then linked to information relating to the sample to be analysed and its source. The physical process of applying a unique identifier to the consumables prior to use enables the decoupling of the physical printing of the consumable from information relating to the source of the sample obviates the need for provision of a printing capability for consumables in laboratories.

The present invention relates to a device for reading multiple cerebrospinal fluid droplets equipped with a micro-drip mechanism and a reading mechanism with a movement mechanism for moving along the X- and Y-axes by mean of worm gears, rails and motors. The device for reading multiple cerebrospinal fluid droplets of the present invention uses optical fibre and a light source to read the microdroplet that is placed on microscope slides located on a base. The device for reading multiple cerebrospinal fluid droplets of the present invention has a moisture-retaining structure configured to maintain moisture inside the device and prevent the microdroplets placed on the slides (3) from evaporating.

An apparatus for rapid screening of tumor stem cells and a method. The apparatus comprises a microscope slide (1) and a cover slip (2) for use under a microscope; the microscope slide (1) is located at the bottom and the cover slip (2) is located at the top; the microscope slide (1) and the cover slip (2) are sealed around their periphery and form an included angle of 2-10 degrees therebetween, the distance between front ends is 200-300 microns, the distance between rear ends is 100-150 microns, a liquid inlet tube (4) and a cleaning tube (5) are provided at the front ends, and a liquid outlet tube (6) is provided at the rear ends; the liquid inlet tube (4) is connected to a blood test vial (7), the cleaning tube (5) is connected to a cleaning vial or a reagent vial (8), and the liquid outlet tube (6) is connected to a blood collection vial (9); the microscope slide (1) is provided with one or more U-shaped grooves (11), the depth of the U-shaped groove (11) is 100-500 microns, and the width of the U-shaped groove (11) is 100-300 microns.

Provided is a microscope slide that allows staining to be performed without a specimen detaching when staining is performed by using an automatic staining device.　The present invention provides a microscope slide comprising an examination region comprising an outer region and a smear region. The outer region is formed by applying an antifouling treatment to the microscope slide. The smear region is shaped by being surrounded by the outer region, and comprises a specimen dropping portion and a staining solution dropping portion. The specimen dropping portion and the staining solution dropping portion are disposed at different positions in the smear region.