374 results about "Functional activity" patented technology

Animated indicators monitor the state of a software container and reflect the state of the container, potentially including information such as amount, type, and activity of the container. As the state of the container changes, an animation routine accordingly changes. Users are presented with up-to-date and detailed information about a container represented by a small graphic pictorial. Thus, the user receives a continuous supply of useful information about the container without having to specifically select and view the container as a full screen representation.

An assessment device is provided which allows for measurement of a position of interest, e.g., a body part, while a subject is in a functional position, such as may be required for the demands of an activity of interest without also requiring a lengthy setup time, tethered connection to other equipment external to the subject or tedious manual measurements. Moreover, an indicator such as an alarm or other output may be provided for receiving immediate, real time feedback, such as when a functional activity falls outside a tolerance or threshold.

A system to realign an organization structure, program product, and associated methods are provided. The system includes an organization realignment program server, a database accessible to the organization realignment program server, a plurality of process development team member computers, a plurality of process development representative computers, and an organization realignment program product stored in the memory of the organization realignment program server to facilitate reorganization program development through online access to the plurality of data records. The organization realignment program product can provide organization analysis web pages to capture data used to analyze and define functions, activities, tasks, and roles, forming a new organization structure, and can provide resource determination web pages to determine a qualified supply of resources available to the new organization structure to thereby determine a skills gap and a resource gap between resources demanded by the new organization structure and the qualified supply of resources.

Improved compositions and methods for AAV mediated gene therapy are disclosed.

Methods for treating patients with cancer and autoimmune disorders using IL-28 and IL-29 molecules. The IL-28 and IL-29 molecules include polypeptides that have homology to the human IL-28 or IL-29 polypeptide sequence and proteins fused to a polypeptide with IL-28 and IL-29 functional activity. The molecules can be used as a monotherapy or in combination with other known cancer and / or autoimmune therapeutics.

Methods for treating patients with cancer and autoimmune disorders using IL-28 and IL-29 molecules. The IL-28 and IL-29 molecules include polypeptides that have homology to the human IL-28 or IL-29 polypeptide sequence and proteins fused to a polypeptide with IL-28 and IL-29 functional activity. The molecules can be used as a monotherapy or in combination with other known cancer and / or autoimmune therapeutics.

Systems and methods are described to detect and anatomically map the location of active nerves or nerve bundles before, during, or after surgical procedures. The optical-based system supports and provides for methods to stimulate nerves in a non-electrolytic manner to activate or stimulate nerves within muscular tissue within the surgical field so that a given nerve's anatomical location or level of functional activity may be made contemporaneously apparent to the surgeon or operating personnel in the form of a neural activity map. The neural activity map provides for mapping of nerve location and classifying the mapped nerves by functional levels. The contemporaneously presented neural activity map enables the surgeon or operating personnel to initially plan a neural muscular surgery before undertaking incisions, or modify the surgical procedure based upon the updated neural mapping of the surgical region of interest.

The present disclosure provides, according to some embodiments, methods and systems for selectively reducing, blocking or inhibiting at least part of the neural activity in an organ of a subject. In preferred embodiments, the method and system are used for selectively blocking at least part of the neural activity in a duodenum of a subject in need thereof. According to some embodiments, the selective blocking occurs through use of laser radiation. According to some embodiments, the selective blocking comprises causing damage to at least part of sensory nerves located within a target area while maintaining functional activity of tissue surrounding the sensory nerves. According to some embodiments, the sensory nerves include neurons configured to transmit signals triggered by food passing through the duodenum, such as, but not limited to, neurohormonal signals.

A protein produced by gene recombinant technology, including at least one domain selected from domains I, II, and III of serum albumin but having a different structure from that of native albumin; and a method of producing the protein. The protein has an enhanced functional activity or activities selected from among various functional activities or serum albumin including antibacterial activity, antioxidative effect, inflammation inhibitory effect, in vivo substance transporting action, and enzymatic activity.

Methods for treating mammals with cancer using molecules that have an IL-21 functional activity are described. The molecules having IL-21 functional activities include polypeptides that have homology to the human IL-21 polypeptide sequence and proteins fused to a polypeptide with IL-21 functional activity. The molecules can be used as a monotherapy or in combination with other known cancer therapeutics.

Metallo-proteins including but not limited to lactoferrin (LF), transferrin (TF) and ovotransferrin (OTF) (all members of transferrin family), ceruloplasmin (CP) and metallo-thionein (MT) were found to stabilize and enhance the bio-functional activity of tocotrienol (T3), T3 mixtures or derivates. The synergism between MP and T3 also promote the intestinal transfer and the ultimate bio-availability of T3 and T3-derivatives for physiological functions. Such functional synergism includes hypocholesterolemic, anti-thrombotic, antioxidant, anti-athermogenic, anti-inflammatory and immuno-regulatory activities of T3 agents. These T3 compositions are useful as pharmaceuticals, in cosmetics, in foods and as nutritional supplements.

The invention described herein relates to novel genes and their encoded proteins, termed Mutants Associated with Resistance to STI-571 (e.g., T315I Bcr-Abl), and to diagnostic and therapeutic methods and compositions useful in the management of various cancers that express MARS. The invention further provides methods for identifying molecules that bind to and / or modulate the functional activity of MARS.

Provided are methods for efficiently and comprehensively screening antibody repertoires from B cells to obtain and produce molecules with binding characteristics and functional activities for use in human therapy.

The present invention relates generally to a method of modulating an inflammatory response in a mammal and to agents useful for same. More particularly, the present invention relates to a method of modulating an inflammatory response in a mammal by modulating the functional activity of activin and thereby modulating the pro-inflammatory mediator cascade. The method of the present invention is useful, inter alia, in the treatment and / or prophylaxis of conditions characterised by an aberrant, unwanted or otherwise inappropriate inflammatory response including, inter alia, sepsis and inflammation of the airway. The present invention is further directed to methods for identifying and / or designing agents capable of modulating activin mediated regulation of the inflammatory response.

Short enzyme donor fragments of β-galactosidase are provided of not more than 40 amino acids, where the short fragments are used as a label and may be substituted with a wide variety of organic compounds, particularly polypeptides having independent functional activity. The enzyme donor finds use in competitive and non-competitive assays, monitoring intracellular events, or other processes where a sensitive non-interfering label is desired.

The invention belongs to the technical field of biology, and discloses a polypeptide containing two chimeric antigen receptor structures, nucleic acid for coding the polypeptide, a modified T lymphocyte, and a preparation method and application of the T lymphocyte. The polypeptide provided by the invention contains the two chimeric antigen receptor (CAR) structures, wherein one chimeric antigen receptor structure specifically targets a tumor cell, and the other one specifically targets a normal B lymphocyte, so that a CAR-T cell is effectively amplified through recognizing the B lymphocyte ofa blood circulation system, and more CAR-T cells arrive at a solid tumor part so as to specifically kill the tumor cell for improving a treatment effect on the solid tumor. The polypeptide further comprises an ScFv structure of an anti-PD-L1 monoclonal antibody, and the CAR-T cells can simultaneously secrete a PD-L1 monoclonal antibody which interdicts an immunosuppressive action medicated by a PD1 / PDL1 signal pathway and T cell failure, so that the treatment effect on the solid tumor is improved, the functional activity of immune cells in vivo is prolonged at the same time, and finally the tumor recurrence is retarded and even avoided.

Methods for treating mammals with cancer using molecules that have an IL-21 functional activity are described. The molecules having IL-21 functional activities include polypeptides that have homology to the human IL-21 polypeptide sequence and proteins fused to a polypeptide with IL-21 functional activity. The molecules can be used as a monotherapy or in combination with other known cancer therapeutics.

A method for constructing banks of human dental pulp stem cells comprises the steps of acquiring basic information, obtaining dental pulp stem cells, cryopreserving and putting dental pulp stem cells into cell banks and recording and checking information. When the banks of dental pulp stem cells are used, recovery and multiplication culture are carried out in accordance with the actual demands. In the method, the dental pulp stem cells are obtained from dental pulp of waste healthy human teeth and a reserve bank for effective resources is established by using system engineering. A great quantity of dental pulp stem cells with functional activities can be obtained through short-term culture of the human dental pulp stem cells stored in the banks and can be stored for long term without losing the activities. Compared with the prior art, the invention is characterized in that the construction operation specification is simple, easy to grasp, safe and feasible; the bank construction cost is low and the standardization degree is high; and the cells from different age groups adopt different cryopreservation solution so that the activities of the recovered cells are enhanced, thus expanding the sources of the cells and enhancing the activities of the cells. The teeth used in the method are those which are extracted for various reasons and are waste, thus greatly saving the medical resources; therefore, the construction has wide application prospect.

The invention discloses a peony tea with a whole flower or a whole petals and a preparation method thereof and relates to a preparation method of edible or medicinal dry peony. The invention comprises the steps of flowers picking, flowers cleaning, dry-proof ingredient spraying, drying and sterilization, sorting, directly packaging or packaging by adding other Chinese herbal medicine for storage; according to the weight percentage per kilogram based on the total amount of the peony tea, the healthy peony tea consists of 18-22 percent of whole flowers of dry peony or peony petals, 0-10 percent of candy sugar, 10-14 percent of dry chrysanthemums, 14-20 percent of dry jujube, 8-10 percent of medlar, 16-20 percent of hawthorn, 12-16 percent of canyon straw, 4-6 percent of orange peel. The peony tea is fresh and natural and can regulate menstruation and alleviate pain; the peony is natural in neutral in nature and is beneficial to the human liver and spleen and can regulate functional activities of vital energy, harmonize the liver meridian, activate the spleen, dissipate hygrosis and replenish qi and blood of the source of vital function, thus having the effects of regulating menstruation and alleviating algomenorrhea for women, preventing cancer, benefiting vital energy, strengthening the middle warmer, alleviating pain and detoxifying, etc.

The invention discloses a novel traditional Chinese medicine composite for treating coma and heart syncope symptoms and a preparation method thereof. The traditional Chinese medicine composite mainly comprises the following raw material medicines: styrax, benzoin, holy basil, rhizoma acori graminei, toad venom, tambac, santalwood, rosa banksiae, nutgrass flatsedge, toosendan fruit, radix aristolochiae, common fibraurea, macrostem onion, fructus citri sarcodactylis, citron, aspongopus, lotus node, madder, dalbergia wood, plant soot, rhizoma ligustici wallichii, corydalis tuber, turmeric, curcuma, mastic, myrrh, radix salviae miltiorrhizae, peach kernel, safflower, radix notoginseng, ground beetle, stiff silkworm, logwood, draconis sanguis, catechu, rhizoma sparganii, rhizoma zedoariae, pangolin scales, spatholobus stem, motherwort, angelica, rhizoma atractylodis, radix puerariae, angelica root, sibirian button bur, magnolia flower, purple common perilla, chrysanthemum, baikal skullcap root and coptis root. The traditional Chinese medicine composite can be prepared into any common oral preparation according to a conventional traditional Chinese medicine preparation method. The invention can obviously improve diseases which are caused by the inverse disorder of the functional activities of qi, fluctuation warp and non-smooth qi of yin and yang and represent coma, delirium, exanimation and asphyxia as main symptoms or are accompanied with the symptoms of asphyxia and coldness of limbs, dottiness and the like, and has definite clinical curative effect, obvious curative effect and quick acting. Because the traditional Chinese medicine composite basically adopts medicine-food homologous medicines specified by the national dispensatory for combination, the traditional Chinese medicine composite has the advantages of low expense, no toxic or side effect basically and the like.

The present invention discloses compositions and methods for antigen-specific suppression of immune responses, including primed immune responses. In particular, the invention discloses antigen-presenting cells, especially dendritic cells, whose level and or functional activity of CD40, or its equivalent, is impaired, abrogated or otherwise reduced, and their use for treating and / or preventing unwanted or deleterious immune responses including those that manifest in autoimmune disease, allergy and transplant rejection.

The invention provides methods of modifying the level of expression or functional activity of factors such as enzymes or other catalytic proteins or structural proteins, alone or in concert, to modify the frequency of meiotic homologous recombination involving the exchange of genetic information between non-sister chromatids from homologous maternal and paternal chromosomes. The steps at which modulation may occur include: homologous chromosome pairing, double-strand break formation; resection; strand invasion; branch migration; and resolution. Methods of plant and animal breeding are also provided that utilize the modulation of meiotic homologous recombination.

The invention relates to a method for preparing full-thickness skin used in toxicity testing by adopting stem cell raft culture, which comprises: 1. preparing and modifying a polymeric dermal scaffold; 2. preparing epidermal stem cells from embryonic stem cells and skin tissues; 3. preparing pancreatic islet cells; 4. preparing a special medium for the full-thickness skin; 5. and constructing the full-thickness skin. By utilizing the characteristics of strong differentiation and proliferation capacity of the epidermal stem cell, the skin morphology, organizational structure and functional activity of the constructed full-thickness skin of the invention can meet the demands of sub-chronic toxicity testing; the synthetic scaffold material has high degree of standardization and small batch-to-batch variation; as a serum free medium is adopted through the skin construction process, the factors influencing tissue construction are reduced, thus providing a foundation for the future use in toxicity testing. The all-thickness skin prepared by the method of the invention is closer to a natural skin, the application of which in the mode of toxicity testing and detection index agrees with practical situation better, thus being able to replace animals to be directly applied to the skin toxicity testing of chemicals, cosmetics, medicines and other health-related products.

A simple and efficient method for the production of stable, clear, high-potency oat extracts is disclosed. The method employs the use of differential dissociation constants and ultrafiltration to stabilise extracts, prevent hazing, and prevent the loss of functional activity as an anti-irritant and anti-oxidant. Also disclosed are compositions of oat extracts derived from whole oat grains and oatmeal. Further disclosed are compositions of oat extracts for use in cosmetic, nutraceutical, therapeutic medical and veterinary preparations.

Methods for treating mammals with cancer using molecules that have an IL-21 functional activity are described. The molecules having IL-21 functional activities include polypeptides that have homology to the human IL-21 polypeptide sequence and proteins fused to a polypeptide with IL-21 functional activity. The molecules can be used as a monotherapy or in combination with other known cancer therapeutics.

Methods for treating mammals with infections, particularly viral infections using molecules that have an IL-21 functional activity are described. The molecules having IL-21 functional activities include polypeptides that have homology to the human IL-21 polypeptide sequence and proteins fused to a polypeptide with IL-21 functional activity. The molecules can be used as a monotherapy or in combination with other known antimicrobial or antiviral therapeutics.

Methods for treating mammals with cancer using molecules that have an IL-21 functional activity are described. The molecules having IL-21 functional activities include polypeptides that have homology to the human IL-21 polypeptide sequence and proteins fused to a polypeptide with IL-21 functional activity. The molecules can be used as a monotherapy or in combination with other known cancer therapeutics.